                         б
<110>  йѧԺ΢о
<120>  KRASͻTϸɸѡ;
<130>  IP210439
<160>  48    
<170>  PatentIn version 3.3
<210>  1
<211>  333
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  1
gccaacagaa ggtgcagcag agcccagaat ccctcattgt tccagaggga ggcatggcct     60
ctctcaactg cacttccagt gatcgtaatg ttgactactt ctggtggtac agacagcact    120
ctgggaaaag ccccaagatg ctgatgtcta tcttctccaa tggtgaaaag gaagaaggca    180
gattcacagt tcacctcaat aaagccagcc tgcatacttc cctgcacatc agagactccc    240
agcccagtga ctctgctctc tacctctgtg cagcaaggga cagcaactat cagttgatct    300
ggggctctgg gaccaagcta attataaagc cag                                 333
<210>  2
<211>  111
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  2
Gln Gln Lys Val Gln Gln Ser Pro Glu Ser Leu Ile Val Pro Glu Gly 
1               5                   10                  15      
Gly Met Ala Ser Leu Asn Cys Thr Ser Ser Asp Arg Asn Val Asp Tyr 
            20                  25                  30          
Phe Trp Trp Tyr Arg Gln His Ser Gly Lys Ser Pro Lys Met Leu Met 
        35                  40                  45              
Ser Ile Phe Ser Asn Gly Glu Lys Glu Glu Gly Arg Phe Thr Val His 
    50                  55                  60                  
Leu Asn Lys Ala Ser Leu His Thr Ser Leu His Ile Arg Asp Ser Gln 
65                  70                  75                  80  
Pro Ser Asp Ser Ala Leu Tyr Leu Cys Ala Ala Arg Asp Ser Asn Tyr 
                85                  90                  95      
Gln Leu Ile Trp Gly Ser Gly Thr Lys Leu Ile Ile Lys Pro Asp 
            100                 105                 110     
<210>  3
<211>  6
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  3
Asp Arg Asn Val Asp Tyr 
1               5       
<210>  4
<211>  6
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  4
Ile Phe Ser Asn Gly Glu 
1               5       
<210>  5
<211>  10
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  5
Ala Ala Arg Asp Ser Asn Tyr Gln Leu Ile 
1               5                   10  
<210>  6
<211>  336
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  6
aggctgcagt cacccaaagc ccaagaaaca aggtggcagt aacaggagga aaggtgacat     60
tgagctgtaa tcagactaat aaccacaaca acatgtactg gtatcggcag gacacggggc    120
atgggctgag gctgatccat tattcatatg gtgctggcag cactgagaaa ggagatatcc    180
ctgatggata caaggcctcc agaccaagcc aagagaactt ctccctcatt ctggagttgg    240
ctaccccctc tcagacatca gtgtacttct gtgccagcgg tgatacaggg ggctatgaac    300
agtacttcgg tcccggcacc aggctcacgg ttttag                              336
<210>  7
<211>  112
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  7
Glu Ala Ala Val Thr Gln Ser Pro Arg Asn Lys Val Ala Val Thr Gly 
1               5                   10                  15      
Gly Lys Val Thr Leu Ser Cys Asn Gln Thr Asn Asn His Asn Asn Met 
            20                  25                  30          
Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              
Ser Tyr Gly Ala Gly Ser Thr Glu Lys Gly Asp Ile Pro Asp Gly Tyr 
    50                  55                  60                  
Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu Glu Leu 
65                  70                  75                  80  
Ala Thr Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Gly Asp Thr 
                85                  90                  95      
Gly Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110         
<210>  8
<211>  5
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  8
Asn Asn His Asn Asn 
1               5   
<210>  9
<211>  6
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  9
Ser Tyr Gly Ala Gly Ser 
1               5       
<210>  10
<211>  11
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  10
Ala Ser Gly Asp Thr Gly Gly Tyr Glu Gln Tyr 
1               5                   10      
<210>  11
<211>  328
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  11
caactagcag aagagaattc gtgggccctg agcgtccacg agggtgaaag tgtcacggtg     60
aattgtagtt acaagacatc cataactgcc ctacagtggt acagacagaa gtcaggcaaa    120
ggccctgccc agctaatctt aatacgttca aatgagagag agaagcgcaa tggaagactc    180
agagccaccc ttgacacctc cagccagagc agctccttgt ccatcactgc tactcggtgt    240
gaagacaccg ctgtgtactt ctgtgccgca tcttctggca gctggcaact catctttgga    300
tctggaaccc aactgacagt tatgcctg                                       328
<210>  12
<211>  109
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  12
Gln Leu Ala Glu Glu Asn Ser Trp Ala Leu Ser Val His Glu Gly Glu 
1               5                   10                  15      
Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser Ile Thr Ala Leu Gln 
            20                  25                  30          
Trp Tyr Arg Gln Lys Ser Gly Lys Gly Pro Ala Gln Leu Ile Leu Ile 
        35                  40                  45              
Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg Leu Arg Ala Thr Leu 
    50                  55                  60                  
Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile Thr Ala Thr Arg Cys 
65                  70                  75                  80  
Glu Asp Thr Ala Val Tyr Phe Cys Ala Ala Ser Ser Gly Ser Trp Gln 
                85                  90                  95      
Leu Ile Phe Gly Ser Gly Thr Gln Leu Thr Val Met Pro 
            100                 105                 
<210>  13
<211>  5
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  13
Thr Ser Ile Thr Ala 
1               5   
<210>  14
<211>  7
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  14
Ile Arg Ser Asn Glu Arg Glu 
1               5           
<210>  15
<211>  10
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  15
Ala Ala Ser Ser Gly Ser Trp Gln Leu Ile 
1               5                   10  
<210>  16
<211>  346
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  16
aatgctggtg tcatccaaac acctaggcac aaggtgacag ggaagggaca agaagcaact     60
ctgtggtgtg agccaatttc aggacatagt gctgttttct ggtacagaca gaccattgtg    120
cagggcctgg agttcctgac ttactttcga aatcaagctc ctatagatga ttcagggatg    180
cccaaggaac gattctcagc tcagatgccc aatcagtcgc actcaactct gaagatccag    240
agcacgcaac cccaggactc agcggtgtat ctttgtgcaa gcagcttaga agggacagtg    300
gaagaaacgc tgtattttgg ctcaggaacc agactgactg ttctcg                   346
<210>  17
<211>  115
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  17
Asn Ala Gly Val Ile Gln Thr Pro Arg His Lys Val Thr Gly Lys Gly 
1               5                   10                  15      
Gln Glu Ala Thr Leu Trp Cys Glu Pro Ile Ser Gly His Ser Ala Val 
            20                  25                  30          
Phe Trp Tyr Arg Gln Thr Ile Val Gln Gly Leu Glu Phe Leu Thr Tyr 
        35                  40                  45              
Phe Arg Asn Gln Ala Pro Ile Asp Asp Ser Gly Met Pro Lys Glu Arg 
    50                  55                  60                  
Phe Ser Ala Gln Met Pro Asn Gln Ser His Ser Thr Leu Lys Ile Gln 
65                  70                  75                  80  
Ser Thr Gln Pro Gln Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu 
                85                  90                  95      
Glu Gly Thr Val Glu Glu Thr Leu Tyr Phe Gly Ser Gly Thr Arg Leu 
            100                 105                 110         
Thr Val Leu 
        115 
<210>  18
<211>  5
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  18
Ser Gly His Ser Ala 
1               5   
<210>  19
<211>  6
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  19
Phe Arg Asn Gln Ala Pro 
1               5       
<210>  20
<211>  13
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  20
Ala Ser Ser Leu Glu Gly Thr Val Glu Glu Thr Leu Tyr 
1               5                   10              
<210>  21
<211>  813
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  21
atgaaatcct ttagtatttc cctagtggtc ctgtggcttc agctaaactg ggtgaacagc     60
caacagaagg tgcagcagag cccagaatcc ctcattgttc cagagggagg catggcctct    120
ctcaactgca cttccagtga tcgtaatgtt gactacttct ggtggtacag acagcactct    180
gggaaaagcc ccaagatgct gatgtctatc ttctccaatg gtgaaaagga agaaggcaga    240
ttcacagttc acctcaataa agccagcctg catacttccc tgcacatcag agactcccag    300
cccagtgact ctgctctcta cctctgtgca gcaagggaca gcaactatca gttgatctgg    360
ggctctggga ccaagctaat tataaagcca gatatccaga accctgaccc tgccgtgtac    420
cagctgagag actctaaatc cagtgacaag tctgtctgcc tattcaccga ttttgattct    480
caaacaaatg tgtcacaaag taaggattct gatgtgtata tcacagacaa atgcgtgcta    540
gacatgaggt ctatggactt caagagcaac agtgctgtgg cctggagcaa caaatctgac    600
tttgcatgtg caaacgcctt caacaacagc attattccag aagacacctt cttccccagc    660
ccagaaagtt cctgtgatgt caagctggtc gagaaaagct ttgaaacaga tacgaaccta    720
aactttcaaa acctgtcagt gattgggttc cgaatcctcc tcctgaaagt ggccgggttt    780
aatctgctca tgacgctgcg gctgtggtcc agc                                 813
<210>  22
<211>  271
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  22
Met Lys Ser Phe Ser Ile Ser Leu Val Val Leu Trp Leu Gln Leu Asn 
1               5                   10                  15      
Trp Val Asn Ser Gln Gln Lys Val Gln Gln Ser Pro Glu Ser Leu Ile 
            20                  25                  30          
Val Pro Glu Gly Gly Met Ala Ser Leu Asn Cys Thr Ser Ser Asp Arg 
        35                  40                  45              
Asn Val Asp Tyr Phe Trp Trp Tyr Arg Gln His Ser Gly Lys Ser Pro 
    50                  55                  60                  
Lys Met Leu Met Ser Ile Phe Ser Asn Gly Glu Lys Glu Glu Gly Arg 
65                  70                  75                  80  
Phe Thr Val His Leu Asn Lys Ala Ser Leu His Thr Ser Leu His Ile 
                85                  90                  95      
Arg Asp Ser Gln Pro Ser Asp Ser Ala Leu Tyr Leu Cys Ala Ala Arg 
            100                 105                 110         
Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ser Gly Thr Lys Leu Ile Ile 
        115                 120                 125             
Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 
Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 
Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     
Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         
Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             
Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 
Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 
Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     
Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     
<210>  23
<211>  927
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  23
atgggctcca ggctcttctt cgtgctctcc agtctcctgt gttcaaaaca catggaggct     60
gcagtcaccc aaagcccaag aaacaaggtg gcagtaacag gaggaaaggt gacattgagc    120
tgtaatcaga ctaataacca caacaacatg tactggtatc ggcaggacac ggggcatggg    180
ctgaggctga tccattattc atatggtgct ggcagcactg agaaaggaga tatccctgat    240
ggatacaagg cctccagacc aagccaagag aacttctccc tcattctgga gttggctacc    300
ccctctcaga catcagtgta cttctgtgcc agcggtgata cagggggcta tgaacagtac    360
ttcggtcccg gcaccaggct cacggtttta gaggacctga aaaacgtgtt cccacccgag    420
gtcgctgtgt ttgagccatc agaagcagag atctcccaca cccaaaaggc cacactggtg    480
tgcctggcca caggcttcta ccccgaccac gtggagctga gctggtgggt gaatgggaag    540
gaggtgcaca gtggggtctg cacagacccg cagcccctca aggagcagcc cgccctcaat    600
gactccagat actgcctgag cagccgcctg agggtctcgg ccaccttctg gcagaacccc    660
cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga cgagtggacc    720
caggataggg ccaaacctgt cacccagatc gtcagcgccg aggcctgggg tagagcagac    780
tgtggcttca cctccgagtc ttaccagcaa ggggtcctgt ctgccaccat cctctatgag    840
atcttgctag ggaaggccac cttgtatgcc gtgctggtca gtgccctcgt gctgatggcc    900
atggtcaaga gaaaggattc cagaggc                                        927
<210>  24
<211>  309
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  24
Met Gly Ser Arg Leu Phe Phe Val Leu Ser Ser Leu Leu Cys Ser Lys 
1               5                   10                  15      
His Met Glu Ala Ala Val Thr Gln Ser Pro Arg Asn Lys Val Ala Val 
            20                  25                  30          
Thr Gly Gly Lys Val Thr Leu Ser Cys Asn Gln Thr Asn Asn His Asn 
        35                  40                  45              
Asn Met Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile 
    50                  55                  60                  
His Tyr Ser Tyr Gly Ala Gly Ser Thr Glu Lys Gly Asp Ile Pro Asp 
65                  70                  75                  80  
Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu 
                85                  90                  95      
Glu Leu Ala Thr Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Gly 
            100                 105                 110         
Asp Thr Gly Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 
Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 
Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     
Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro 
            180                 185                 190         
Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             
Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 
Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 
Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     
Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
            260                 265                 270         
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             
Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 
Lys Asp Ser Arg Gly 
305                 
<210>  25
<211>  804
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  25
atgcacagcc tcctggggtt gttgttgtgg ctgcaactga caagggtgaa tagtcaacta     60
gcagaagaga attcgtgggc cctgagcgtc cacgagggtg aaagtgtcac ggtgaattgt    120
agttacaaga catccataac tgccctacag tggtacagac agaagtcagg caaaggccct    180
gcccagctaa tcttaatacg ttcaaatgag agagagaagc gcaatggaag actcagagcc    240
acccttgaca cctccagcca gagcagctcc ttgtccatca ctgctactcg gtgtgaagac    300
accgctgtgt acttctgtgc cgcatcttct ggcagctggc aactcatctt tggatctgga    360
acccaactga cagttatgcc tgatatccag aaccctgacc ctgccgtgta ccagctgaga    420
gactctaaat ccagtgacaa gtctgtctgc ctattcaccg attttgattc tcaaacaaat    480
gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca aatgcgtgct agacatgagg    540
tctatggact tcaagagcaa cagtgctgtg gcctggagca acaaatctga ctttgcatgt    600
gcaaacgcct tcaacaacag cattattcca gaagacacct tcttccccag cccagaaagt    660
tcctgtgatg tcaagctggt cgagaaaagc tttgaaacag atacgaacct aaactttcaa    720
aacctgtcag tgattgggtt ccgaatcctc ctcctgaaag tggccgggtt taatctgctc    780
atgacgctgc ggctgtggtc cagc                                           804
<210>  26
<211>  268
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  26
Met His Ser Leu Leu Gly Leu Leu Leu Trp Leu Gln Leu Thr Arg Val 
1               5                   10                  15      
Asn Ser Gln Leu Ala Glu Glu Asn Ser Trp Ala Leu Ser Val His Glu 
            20                  25                  30          
Gly Glu Ser Val Thr Val Asn Cys Ser Tyr Lys Thr Ser Ile Thr Ala 
        35                  40                  45              
Leu Gln Trp Tyr Arg Gln Lys Ser Gly Lys Gly Pro Ala Gln Leu Ile 
    50                  55                  60                  
Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Asn Gly Arg Leu Arg Ala 
65                  70                  75                  80  
Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile Thr Ala Thr 
                85                  90                  95      
Arg Cys Glu Asp Thr Ala Val Tyr Phe Cys Ala Ala Ser Ser Gly Ser 
            100                 105                 110         
Trp Gln Leu Ile Phe Gly Ser Gly Thr Gln Leu Thr Val Met Pro Asp 
        115                 120                 125             
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
    130                 135                 140                 
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
145                 150                 155                 160 
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
                165                 170                 175     
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
            180                 185                 190         
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
        195                 200                 205             
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
    210                 215                 220                 
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
225                 230                 235                 240 
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             
<210>  27
<211>  939
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  27
atggccccca ggctcctttt ctgtctggtt ctttgcttct tgagagcaga accaacaaat     60
gctggtgtca tccaaacacc taggcacaag gtgacaggga agggacaaga agcaactctg    120
tggtgtgagc caatttcagg acatagtgct gttttctggt acagacagac cattgtgcag    180
ggcctggagt tcctgactta ctttcgaaat caagctccta tagatgattc agggatgccc    240
aaggaacgat tctcagctca gatgcccaat cagtcgcact caactctgaa gatccagagc    300
acgcaacccc aggactcagc ggtgtatctt tgtgcaagca gcttagaagg gacagtggaa    360
gaaacgctgt attttggctc aggaaccaga ctgactgttc tcgaggacct gaaaaacgtg    420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag    480
gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg    540
gtgaatggga aggaggtgca cagtggggtc tgcacagacc cgcagcccct caaggagcag    600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc    660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat    720
gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg    780
ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc    840
atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc    900
gtgctgatgg ccatggtcaa gagaaaggat tccagaggc                           939
<210>  28
<211>  313
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  28
Met Ala Pro Arg Leu Leu Phe Cys Leu Val Leu Cys Phe Leu Arg Ala 
1               5                   10                  15      
Glu Pro Thr Asn Ala Gly Val Ile Gln Thr Pro Arg His Lys Val Thr 
            20                  25                  30          
Gly Lys Gly Gln Glu Ala Thr Leu Trp Cys Glu Pro Ile Ser Gly His 
        35                  40                  45              
Ser Ala Val Phe Trp Tyr Arg Gln Thr Ile Val Gln Gly Leu Glu Phe 
    50                  55                  60                  
Leu Thr Tyr Phe Arg Asn Gln Ala Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  
Lys Glu Arg Phe Ser Ala Gln Met Pro Asn Gln Ser His Ser Thr Leu 
                85                  90                  95      
Lys Ile Gln Ser Thr Gln Pro Gln Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         
Ser Ser Leu Glu Gly Thr Val Glu Glu Thr Leu Tyr Phe Gly Ser Gly 
        115                 120                 125             
Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 
Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             
<210>  29
<211>  630
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  29
catatgtggg ttaatagcca gcagaaagtt cagcagagtc cggaaagcct gatcgttccg     60
gaaggcggca tggccagcct gaattgcacc agcagcgatc gcaatgttga ttacttctgg    120
tggtaccgcc agcatagcgg caaaagcccg aaaatgctga tgagcatctt cagcaatggc    180
gaaaaagaag aaggccgctt caccgttcat ctgaataaag ccagtctgca taccagcctg    240
catatccgcg atagccagcc gagcgatagc gccctgtacc tgtgcgccgc ccgcgatagc    300
aattaccagc tgatctgggg cagcggcacc aaactgatca tcaaaccgga tatccagaat    360
ccggatccgg ccgtttacca gctgcgcgat agcaaaagca gcgataaaag cgtttgcctg    420
ttcaccgatt tcgatagcca gaccaatgtt agccagagca aagatagcga tgtttacatc    480
accgataaat gcgttctgga tatgcgcagc atggatttca aaagcaatag cgccgttgcc    540
tggagcaata aaagcgattt cgcctgcgcc aatgccttca ataatagcat catcccggaa    600
gataccttct tcccgtctcc ggaaagcagc                                     630
<210>  30
<211>  738
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  30
atgaaacata tggaagccgc cgttacccag agcccgcgca ataaagttgc cgttaccggc     60
ggcaaagtta ccctgagctg caatcagacc aataatcata ataatatgta ctggtaccgc    120
caggataccg gccatggcct gcgcctgatc cattacagct acggcgccgg cagcaccgaa    180
aaaggcgata tcccggatgg ctacaaagcc agccgcccga gccaggaaaa tttcagcctg    240
atcctggaac tggccacccc gagccagacc agcgtttact tctgcgccag cggcgatacc    300
ggcggctacg aacagtactt cggcccgggc acccgcctga ccgttctgga agatctgaaa    360
aatgttttcc cgccggaagt tgccgttttc gaaccgagcg aagccgaaat cagccatacc    420
cagaaagcca ccctggtttg cctggccacc ggcttctacc cggatcatgt tgaactgagc    480
tggtgggtta atggcaaaga agttcatagc ggcgtttgca ccgatccgca gccgctgaaa    540
gaacagccgg ccctgaatga tagccgctac gccctgagca gccgcctgcg cgttagcgcc    600
accttctggc aggatccgcg caatcatttc cgctgccagg ttcagttcta cggcctgagc    660
gaaaatgatg aatggaccca ggatcgcgcc aaaccggtta cccagatcgt tagcgccgaa    720
gcctggggcc gcgccgat                                                  738
<210>  31
<211>  624
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  31
atgcgcgtta atagccagct ggccgaagaa aatagctggg ccctgagcgt tcatgaaggc     60
gaaagcgtta ccgttaattg cagctacaaa accagtatca ccgccctgca gtggtaccgc    120
cagaaaagcg gcaaaggccc ggcccagctg atcctgatcc gcagcaatga acgcgaaaaa    180
cgcaatggcc gcctgcgcgc caccctggat accagcagcc agagcagcag cctgtctatc    240
accgccaccc gctgcgaaga taccgccgtt tacttctgcg ccgccagcag cggcagctgg    300
cagctgatct tcggcagcgg cacccagctg accgttatgc cggatatcca gaatccggat    360
ccggccgttt accagctgcg cgatagcaaa agcagcgata aaagcgtttg cctgttcacc    420
gatttcgata gccagaccaa tgttagccag agcaaagata gcgatgttta catcaccgat    480
aaatgcgttc tggatatgcg cagcatggat ttcaaaagca atagcgccgt tgcctggagc    540
aataaaagcg atttcgcctg cgccaatgcc ttcaataata gcatcatccc ggaagatacc    600
ttcttcccga gcccggaaag cagc                                           624
<210>  32
<211>  747
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  32
atggaaccga ccaatgccgg cgttatccag accccgcgcc ataaagttac cggcaaaggc     60
caggaagcca ccctgtggtg cgaaccgatc agcggccaca gtgccgtttt ctggtaccgc    120
cagaccatcg ttcagggcct ggaattcctg acctacttcc gcaatcaggc cccgatcgat    180
gatagcggca tgccgaaaga acgcttcagc gcccagatgc cgaatcagag ccatagcacc    240
ctgaaaatcc agagcaccca gccgcaggac agcgccgttt acctgtgcgc cagcagcctg    300
gaaggcaccg ttgaagaaac cctgtacttc ggcagcggca cccgcctgac cgttctggaa    360

gatctgaaaa atgttttccc gccggaagtt gccgttttcg aaccgagcga agccgaaatc    420
agccataccc agaaagccac cctggtttgc ctggccaccg gcttctaccc ggatcatgtt    480
gaactgagct ggtgggttaa tggcaaagaa gttcatagcg gcgtttgcac cgatccgcag    540
ccgctgaaag aacagccggc cctgaatgat agccgctacg ccctgagcag ccgcctgcgc    600
gttagcgcca ccttctggca ggatccgcgc aatcatttcc gctgccaggt tcagttctac    660
ggcctgagcg aaaatgatga atggacccag gatcgcgcca aaccggttac ccagatcgtt    720
agcgccgaag cctggggccg cgccgat                                        747
<210>  33
<211>  15
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  33
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  
<210>  34
<211>  9
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  34
Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   
<210>  35
<211>  9
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  35
Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   
<210>  36
<211>  9
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  36
Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   
<210>  37
<211>  9
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  37
Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   
<210>  38
<211>  10
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  38

Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10  
<210>  39
<211>  10
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  39
Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10  
<210>  40
<211>  10
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  40
Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10  
<210>  41
<211>  10
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  41
Val Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   10  
<210>  42
<211>  18
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  42
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      
Gly Pro 
        
<210>  43
<211>  274
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  43
Met Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      
Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          
Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              
Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  
Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  
Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      
Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         
Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             
Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 
Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 
Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     
Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         
Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             
Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 
Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 
Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     
Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         
Arg Trp 
        
<210>  44
<211>  822
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  44
atgagccata gcatgcgcta tttttatacc agcgtgagcc gcccgggccg cggcgaaccg     60
cgctttattg cggtgggcta tgtggatgat acccagtttg tgcgctttga tagcgatgcg    120
gcgagccagc gcatggaacc gcgcgcgccg tggattgaac aggaaggccc ggaatattgg    180
gatcaggaaa cccgcaacgt gaaagcgcag agccagaccg atcgcgtgga tctgggcacc    240
ctgcgcggct attataacca gagcgaagat ggcagccata ccattcagat tatgtatggc    300
tgcgatgtgg gcccggatgg ccgctttctg cgcggctatc gccaggatgc gtatgatggc    360
aaagattata ttgcgctgaa cgaagatctg cgcagctgga ccgcggcgga tatggcggcg    420
cagattacca aacgcaaatg ggaagcggcg catgcggcgg aacagcagcg cgcgtatctg    480
gaaggccgct gcgtggaatg gctgcgccgc tatctggaaa acggcaaaga aaccctgcag    540
cgcaccgatc cgccgaaaac ccatatgacc catcatccga ttagcgatca tgaagcgacc    600
ctgcgctgct gggcgctggg cttttatccg gcggaaatta ccctgacctg gcagcgcgat    660
ggcgaagatc agacccagga taccgaactg gtggaaaccc gcccggcggg cgatggcacc    720
tttcagaaat gggcggcggt ggtggtgccg agcggcgaag aacagcgcta tacctgccat    780
gtgcagcatg aaggcctgcc gaaaccgctg accctgcgct gg                       822
<210>  45
<211>  274
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  45
Met Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      
Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          
Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              
Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  
Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  
Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      
Ile Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         
Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             
Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 
Arg Lys Trp Glu Ala Ala His Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 
Asp Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     
Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         
Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             
Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 
Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 
Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     
Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         
Arg Trp 
        
<210>  46
<211>  822
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  46
atgagccata gcatgcgcta tttttttacc agcgtgagcc gcccgggccg cggcgaaccg     60
cgctttattg cggtgggcta tgtggatgat acccagtttg tgcgctttga tagcgatgcg    120
gcgagccagc gcatggaacc gcgcgcgccg tggattgaac aggaaggccc ggaatattgg    180
gatcaggaaa cccgcaacgt gaaagcgcag agccagaccg atcgcgtgga tctgggcacc    240
ctgcgcggct attataacca gagcgaagcg ggcagccata ccattcagat tatgtatggc    300
tgcgatgtgg gcagcgatgg ccgctttctg cgcggctatc gccaggatgc gtatgatggc    360
aaagattata ttgcgctgaa cgaagatctg cgcagctgga ccgcggcgga tatggcggcg    420
cagattacca aacgcaaatg ggaagcggcg catgaagcgg aacagctgcg cgcgtatctg    480
gatggcacct gcgtggaatg gctgcgccgc tatctggaaa acggcaaaga aaccctgcag    540
cgcaccgatc cgccgaaaac ccatatgacc catcatccga ttagcgatca tgaagcgacc    600
ctgcgctgct gggcgctggg cttttatccg gcggaaatta ccctgacctg gcagcgcgat    660
ggcgaagatc agacccagga taccgaactg gtggaaaccc gcccggcggg cgatggcacc    720
tttcagaaat gggcggcggt ggtggtgccg agcggcgaag aacagcgcta tacctgccat    780
gtgcagcatg aaggcctgcc gaaaccgctg accctgcgct gg                       822
<210>  47
<211>  100
<212>  PRT
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  47
Met Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala 
1               5                   10                  15      
Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His 
            20                  25                  30          
Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu 
        35                  40                  45              
Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr 
    50                  55                  60                  
Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala 
65                  70                  75                  80  
Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp 
                85                  90                  95      
Asp Arg Asp Met 
            100 
<210>  48
<211>  300
<212>  DNA
<213>  ˹ģArtificial
<220>
<223>  ˹ϳɵ
<400>  48
atgattcagc gcaccccgaa aattcaggtg tatagccgcc atccggcgga aaacggcaaa     60
agcaactttc tgaactgcta tgtgagcggc tttcatccga gcgatattga agtggatctg    120
ctgaaaaacg gcgaacgcat tgaaaaagtg gaacatagcg atctgagctt tagcaaagat    180
tggagctttt atctgctgta ttataccgaa tttaccccga ccgaaaaaga tgaatatgcg    240
tgccgcgtga accatgtgac cctgagccag ccgaaaattg tgaaatggga tcgcgatatg    300

