                         SEQUENCE LISTING

<110>  Humabs Biomed SA
 
<120>  ANTIBODIES AGAINST SARS-COV-2

<130>  930585.418WO

<140>  PCT
<141>  2021-09-28

<150>  US 63/170,356 
<151>  2021-04-02

<150>  US 63/137,112
<151>  2021-01-13

<150>  US 63/119,545 
<151>  2020-11-30

<150>  US 63/112,505 
<151>  2020-11-11

<150>  US 63/111,435
<151>  2020-11-09

<150>  US 63/084,501 
<151>  2020-09-28

<160>  467   

<170>  PatentIn version 3.5

<210>  1
<211>  29902
<212>  DNA
<213>  SARS-CoV-2 beta

<400>  1
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct       60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact      120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc      180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt      240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac      300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg      360

agactccgtg gaggaggtct tatcagaggc cgtcaacatc ttaaagatgg cacttgtggc      420

ttagtagaag ttgaaaaagg cgttttgcct caacttgaac agccctatgt gttcatcaaa      480

cgttcggatg ctcgaactgc acctcatggt catgttatgg ttgagctggt agcagaactc      540

gaaggcattc agtacggtcg tagtggtgag acacttggtg tccttgtccc tcatgtgggc      600

gaaataccag tggcttaccg caaggttctt cttcgtaaga acggtaataa aggagctggt      660

ggccatagtt acggcgccga tctaaagtca tttgacttag gcgacgagct tggcactgat      720

ccttatgaag attttcaaga aaactggaac actaaacata gcagtggtgt tacccgtgaa      780

ctcatgcgtg agcttaacgg aggggcatac actcgctatg tcgataacaa cttctgtggc      840

cctgatggct accctcttga gtgcattaaa gaccttctag cacgtgctgg taaagcttca      900

tgcactttgt ccgaacaact ggactttatt gacactaaga ggggtgtata ctgctgccgt      960

gaacatgagc atgaaattgc ttggtacacg gaacgttctg aaaagagcta tgaattgcag     1020

acaccttttg aaattaaatt ggcaaagaaa tttgacacct tcaatgggga atgtccaaat     1080

tttgtatttc ccttaaattc cataatcaag actattcaac caagggttga aaagaaaaag     1140

cttgatggct ttatgggtag aattcgatct gtctatccag ttgcgtcacc aaatgaatgc     1200

aaccaaatgt gcctttcaac tctcatgaag tgtgatcatt gtggtgaaac ttcatggcag     1260

acgggcgatt ttgttaaagc cacttgcgaa ttttgtggca ctgagaattt gactaaagaa     1320

ggtgccacta cttgtggtta cttaccccaa aatgctgttg ttaaaattta ttgtccagca     1380

tgtcacaatt cagaagtagg acctgagcat agtcttgccg aataccataa tgaatctggc     1440

ttgaaaacca ttcttcgtaa gggtggtcgc actattgcct ttggaggctg tgtgttctct     1500

tatgttggtt gccataacaa gtgtgcctat tgggttccac gtgctagcgc taacataggt     1560

tgtaaccata caggtgttgt tggagaaggt tccgaaggtc ttaatgacaa ccttcttgaa     1620

atactccaaa aagagaaagt caacatcaat attgttggtg actttaaact taatgaagag     1680

atcgccatta ttttggcatc tttttctgct tccacaagtg cttttgtgga aactgtgaaa     1740

ggtttggatt ataaagcatt caaacaaatt gttgaatcct gtggtaattt taaagttaca     1800

aaaggaaaag ctaaaaaagg tgcctggaat attggtgaac agaaatcaat actgagtcct     1860

ctttatgcat ttgcatcaga ggctgctcgt gttgtacgat caattttctc ccgcactctt     1920

gaaactgctc aaaattctgt gcgtgtttta cagaaggccg ctataacaat actagatgga     1980

atttcacagt attcactgag actcattgat gctatgatgt tcacatctga tttggctact     2040

aacaatctag ttgtaatggc ctacattaca ggtggtgttg ttcagttgac ttcgcagtgg     2100

ctaactaaca tctttggcac tgtttatgaa aaactcaaac ccgtccttga ttggcttgaa     2160

gagaagttta aggaaggtgt agagtttctt agagacggtt gggaaattgt taaatttatc     2220

tcaacctgtg cttgtgaaat tgtcggtgga caaattgtca cctgtgcaaa ggaaattaag     2280

gagagtgttc agacattctt taagcttgta aataaatttt tggctttgtg tgctgactct     2340

atcattattg gtggagctaa acttaaagcc ttgaatttag gtgaaacatt tgtcacgcac     2400

tcaaagggat tgtacagaaa gtgtgttaaa tccagagaag aaactggcct actcatgcct     2460

ctaaaagccc caaaagaaat tatcttctta gagggagaaa cacttcccac agaagtgtta     2520

acagaggaag ttgtcttgaa aactggtgat ttacaaccat tagaacaacc tactagtgaa     2580

gctgttgaag ctccattggt tggtacacca gtttgtatta acgggcttat gttgctcgaa     2640

atcaaagaca cagaaaagta ctgtgccctt gcacctaata tgatggtaac aaacaatacc     2700

ttcacactca aaggcggtgc accaacaaag gttacttttg gtgatgacac tgtgatagaa     2760

gtgcaaggtt acaagagtgt gaatatcact tttgaacttg atgaaaggat tgataaagta     2820

cttaatgaga agtgctctgc ctatacagtt gaactcggta cagaagtaaa tgagttcgcc     2880

tgtgttgtgg cagatgctgt cataaaaact ttgcaaccag tatctgaatt acttacacca     2940

ctgggcattg atttagatga gtggagtatg gctacatact acttatttga tgagtctggt     3000

gagtttaaat tggcttcaca tatgtattgt tctttctacc ctccagatga ggatgaagaa     3060

gaaggtgatt gtgaagaaga agagtttgag ccatcaactc aatatgagta tggtactgaa     3120

gatgattacc aaggtaaacc tttggaattt ggtgccactt ctgctgctct tcaacctgaa     3180

gaagagcaag aagaagattg gttagatgat gatagtcaac aaactgttgg tcaacaagac     3240

ggcagtgagg acaatcagac aactactatt caaacaattg ttgaggttca acctcaatta     3300

gagatggaac ttacaccagt tgttcagact attgaagtga atagttttag tggttattta     3360

aaacttactg acaatgtata cattaaaaat gcagacattg tggaagaagc taaaaaggta     3420

aaaccaacag tggttgttaa tgcagccaat gtttacctta aacatggagg aggtgttgca     3480

ggagccttaa ataaggctac taacaatgcc atgcaagttg aatctgatga ttacatagct     3540

actaatggac cacttaaagt gggtggtagt tgtgttttaa gcggacacaa tcttgctaaa     3600

cactgtcttc atgttgtcgg cccaaatgtt aacaaaggtg aagacattca acttcttaag     3660

agtgcttatg aaaattttaa tcagcacgaa gttctacttg caccattatt atcagctggt     3720

atttttggtg ctgaccctat acattcttta agagtttgtg tagatactgt tcgcacaaat     3780

gtctacttag ctgtctttga taaaaatctc tatgacaaac ttgtttcaag ctttttggaa     3840

atgaagagtg aaaagcaagt tgaacaaaag atcgctgaga ttcctaaaga ggaagttaag     3900

ccatttataa ctgaaagtaa accttcagtt gaacagagaa aacaagatga taagaaaatc     3960

aaagcttgtg ttgaagaagt tacaacaact ctggaagaaa ctaagttcct cacagaaaac     4020

ttgttacttt atattgacat taatggcaat cttcatccag attctgccac tcttgttagt     4080

gacattgaca tcactttctt aaagaaagat gctccatata tagtgggtga tgttgttcaa     4140

gagggtgttt taactgctgt ggttatacct actaaaaagg ctggtggcac tactgaaatg     4200

ctagcgaaag ctttgagaaa agtgccaaca gacaattata taaccactta cccgggtcag     4260

ggtttaaatg gttacactgt agaggaggca aagacagtgc ttaaaaagtg taaaagtgcc     4320

ttttacattc taccatctat tatctctaat gagaagcaag aaattcttgg aactgtttct     4380

tggaatttgc gagaaatgct tgcacatgca gaagaaacac gcaaattaat gcctgtctgt     4440

gtggaaacta aagccatagt ttcaactata cagcgtaaat ataagggtat taaaatacaa     4500

gagggtgtgg ttgattatgg tgctagattt tacttttaca ccagtaaaac aactgtagcg     4560

tcacttatca acacacttaa cgatctaaat gaaactcttg ttacaatgcc acttggctat     4620

gtaacacatg gcttaaattt ggaagaagct gctcggtata tgagatctct caaagtgcca     4680

gctacagttt ctgtttcttc acctgatgct gttacagcgt ataatggtta tcttacttct     4740

tcttctaaaa cacctgaaga acattttatt gaaaccatct cacttgctgg ttcctataaa     4800

gattggtcct attctggaca atctacacaa ctaggtatag aatttcttaa gagaggtgat     4860

aaaagtgtat attacactag taatcctacc acattccacc tagatggtga agttatcacc     4920

tttgacaatc ttaagacact tctttctttg agagaagtga ggactattaa ggtgtttaca     4980

acagtagaca acattaacct ccacacgcaa gttgtggaca tgtcaatgac atatggacaa     5040

cagtttggtc caacttattt ggatggagct gatgttacta aaataaaacc tcataattca     5100

catgaaggta aaacatttta tgttttacct aatgatgaca ctctacgtgt tgaggctttt     5160

gagtactacc acacaactga tcctagtttt ctgggtaggt acatgtcagc attaaatcac     5220

actaaaaagt ggaaataccc acaagttaat ggtttaactt ctattaaatg ggcagataac     5280

aactgttatc ttgccactgc attgttaaca ctccaacaaa tagagttgaa gtttaatcca     5340

cctgctctac aagatgctta ttacagagca agggctggtg aagctgctaa cttttgtgca     5400

cttatcttag cctactgtaa taagacagta ggtgagttag gtgatgttag agaaacaatg     5460

agttacttgt ttcaacatgc caatttagat tcttgcaaaa gagtcttgaa cgtggtgtgt     5520

aaaacttgtg gacaacagca gacaaccctt aagggtgtag aagctgttat gtacatgggc     5580

acactttctt atgaacaatt taagaaaggt gttcagatac cttgtacgtg tggtaaacaa     5640

gctacaaaat atctagtaca acaggagtca ccttttgtta tgatgtcagc accacctgct     5700

cagtatgaac ttaagcatgg tacatttact tgtgctagtg agtacactgg taattaccag     5760

tgtggtcact ataaacatat aacttctaaa gaaactttgt attgcataga cggtgcttta     5820

cttacaaagt cctcagaata caaaggtcct attacggatg ttttctacaa agaaaacagt     5880

tacacaacaa ccataaaacc agttacttat aaattggatg gtgttgtttg tacagaaatt     5940

gaccctaagt tggacaatta ttataagaaa gacaattctt atttcacaga gcaaccaatt     6000

gatcttgtac caaaccaacc atatccaaac gcaagcttcg ataattttaa gtttgtatgt     6060

gataatatca aatttgctga tgatttaaac cagttaactg gttataagaa acctgcttca     6120

agagagctta aagttacatt tttccctgac ttaaatggtg atgtggtggc tattgattat     6180

aaacactaca caccctcttt taagaaagga gctaaattgt tacataaacc tattgtttgg     6240

catgttaaca atgcaactaa taaagccacg tataaaccaa atacctggtg tatacgttgt     6300

ctttggagca caaaaccagt tgaaacatca aattcgtttg atgtactgaa gtcagaggac     6360

gcgcagggaa tggataatct tgcctgcgaa gatctaaaac cagtctctga agaagtagtg     6420

gaaaatccta ccatacagaa agacgttctt gagtgtaatg tgaaaactac cgaagttgta     6480

ggagacatta tacttaaacc agcaaataat agtttaaaaa ttacagaaga ggttggccac     6540

acagatctaa tggctgctta tgtagacaat tctagtctta ctattaagaa acctaatgaa     6600

ttatctagag tattaggttt gaaaaccctt gctactcatg gtttagctgc tgttaatagt     6660

gtcccttggg atactatagc taattatgct aagccttttc ttaacaaagt tgttagtaca     6720

actactaaca tagttacacg gtgtttaaac cgtgtttgta ctaattatat gccttatttc     6780

tttactttat tgctacaatt gtgtactttt actagaagta caaattctag aattaaagca     6840

tctatgccga ctactatagc aaagaatact gttaagagtg tcggtaaatt ttgtctagag     6900

gcttcattta attatttgaa gtcacctaat ttttctaaac tgataaatat tataatttgg     6960

tttttactat taagtgtttg cctaggttct ttaatctact caaccgctgc tttaggtgtt     7020

ttaatgtcta atttaggcat gccttcttac tgtactggtt acagagaagg ctatttgaac     7080

tctactaatg tcactattgc aacctactgt actggttcta taccttgtag tgtttgtctt     7140

agtggtttag attctttaga cacctatcct tctttagaaa ctatacaaat taccatttca     7200

tcttttaaat gggatttaac tgcttttggc ttagttgcag agtggttttt ggcatatatt     7260

cttttcacta ggtttttcta tgtacttgga ttggctgcaa tcatgcaatt gtttttcagc     7320

tattttgcag tacattttat tagtaattct tggcttatgt ggttaataat taatcttgta     7380

caaatggccc cgatttcagc tatggttaga atgtacatct tctttgcatc attttattat     7440

gtatggaaaa gttatgtgca tgttgtagac ggttgtaatt catcaacttg tatgatgtgt     7500

tacaaacgta atagagcaac aagagtcgaa tgtacaacta ttgttaatgg tgttagaagg     7560

tccttttatg tctatgctaa tggaggtaaa ggcttttgca aactacacaa ttggaattgt     7620

gttaattgtg atacattctg tgctggtagt acatttatta gtgatgaagt tgcgagagac     7680

ttgtcactac agtttaaaag accaataaat cctactgacc agtcttctta catcgttgat     7740

agtgttacag tgaagaatgg ttccatccat ctttactttg ataaagctgg tcaaaagact     7800

tatgaaagac attctctctc tcattttgtt aacttagaca acctgagagc taataacact     7860

aaaggttcat tgcctattaa tgttatagtt tttgatggta aatcaaaatg tgaagaatca     7920

tctgcaaaat cagcgtctgt ttactacagt cagcttatgt gtcaacctat actgttacta     7980

gatcaggcat tagtgtctga tgttggtgat agtgcggaag ttgcagttaa aatgtttgat     8040

gcttacgtta atacgttttc atcaactttt aacgtaccaa tggaaaaact caaaacacta     8100

gttgcaactg cagaagctga acttgcaaag aatgtgtcct tagacaatgt cttatctact     8160

tttatttcag cagctcggca agggtttgtt gattcagatg tagaaactaa agatgttgtt     8220

gaatgtctta aattgtcaca tcaatctgac atagaagtta ctggcgatag ttgtaataac     8280

tatatgctca cctataacaa agttgaaaac atgacacccc gtgaccttgg tgcttgtatt     8340

gactgtagtg cgcgtcatat taatgcgcag gtagcaaaaa gtcacaacat tgctttgata     8400

tggaacgtta aagatttcat gtcattgtct gaacaactac gaaaacaaat acgtagtgct     8460

gctaaaaaga ataacttacc ttttaagttg acatgtgcaa ctactagaca agttgttaat     8520

gttgtaacaa caaagatagc acttaagggt ggtaaaattg ttaataattg gttgaagcag     8580

ttaattaaag ttacacttgt gttccttttt gttgctgcta ttttctattt aataacacct     8640

gttcatgtca tgtctaaaca tactgacttt tcaagtgaaa tcataggata caaggctatt     8700

gatggtggtg tcactcgtga catagcatct acagatactt gttttgctaa caaacatgct     8760

gattttgaca catggtttag ccagcgtggt ggtagttata ctaatgacaa agcttgccca     8820

ttgattgctg cagtcataac aagagaagtg ggttttgtcg tgcctggttt gcctggcacg     8880

atattacgca caactaatgg tgactttttg catttcttac ctagagtttt tagtgcagtt     8940

ggtaacatct gttacacacc atcaaaactt atagagtaca ctgactttgc aacatcagct     9000

tgtgttttgg ctgctgaatg tacaattttt aaagatgctt ctggtaagcc agtaccatat     9060

tgttatgata ccaatgtact agaaggttct gttgcttatg aaagtttacg ccctgacaca     9120

cgttatgtgc tcatggatgg ctctattatt caatttccta acacctacct tgaaggttct     9180

gttagagtgg taacaacttt tgattctgag tactgtaggc acggcacttg tgaaagatca     9240

gaagctggtg tttgtgtatc tactagtggt agatgggtac ttaacaatga ttattacaga     9300

tctttaccag gagttttctg tggtgtagat gctgtaaatt tacttactaa tatgtttaca     9360

ccactaattc aacctattgg tgctttggac atatcagcat ctatagtagc tggtggtatt     9420

gtagctatcg tagtaacatg ccttgcctac tattttatga ggtttagaag agcttttggt     9480

gaatacagtc atgtagttgc ctttaatact ttactattcc ttatgtcatt cactgtactc     9540

tgtttaacac cagtttactc attcttacct ggtgtttatt ctgttattta cttgtacttg     9600

acattttatc ttactaatga tgtttctttt ttagcacata ttcagtggat ggttatgttc     9660

acacctttag tacctttctg gataacaatt gcttatatca tttgtatttc cacaaagcat     9720

ttctattggt tctttagtaa ttacctaaag agacgtgtag tctttaatgg tgtttccttt     9780

agtacttttg aagaagctgc gctgtgcacc tttttgttaa ataaagaaat gtatctaaag     9840

ttgcgtagtg atgtgctatt acctcttacg caatataata gatacttagc tctttataat     9900

aagtacaagt attttagtgg agcaatggat acaactagct acagagaagc tgcttgttgt     9960

catctcgcaa aggctctcaa tgacttcagt aactcaggtt ctgatgttct ttaccaacca    10020

ccacaaacct ctatcacctc agctgttttg cagagtggtt ttagaaaaat ggcattccca    10080

tctggtaaag ttgagggttg tatggtacaa gtaacttgtg gtacaactac acttaacggt    10140

ctttggcttg atgacgtagt ttactgtcca agacatgtga tctgcacctc tgaagacatg    10200

cttaacccta attatgaaga tttactcatt cgtaagtcta atcataattt cttggtacag    10260

gctggtaatg ttcaactcag ggttattgga cattctatgc aaaattgtgt acttaagctt    10320

aaggttgata cagccaatcc taagacacct aagtataagt ttgttcgcat tcaaccagga    10380

cagacttttt cagtgttagc ttgttacaat ggttcaccat ctggtgttta ccaatgtgct    10440

atgaggccca atttcactat taagggttca ttccttaatg gttcatgtgg tagtgttggt    10500

tttaacatag attatgactg tgtctctttt tgttacatgc accatatgga attaccaact    10560

ggagttcatg ctggcacaga cttagaaggt aacttttatg gaccttttgt tgacaggcaa    10620

acagcacaag cagctggtac ggacacaact attacagtta atgttttagc ttggttgtac    10680

gctgctgtta taaatggaga caggtggttt ctcaatcgat ttaccacaac tcttaatgac    10740

tttaaccttg tggctatgaa gtacaattat gaacctctaa cacaagacca tgttgacata    10800

ctaggacctc tttctgctca aactggaatt gccgttttag atatgtgtgc ttcattaaaa    10860

gaattactgc aaaatggtat gaatggacgt accatattgg gtagtgcttt attagaagat    10920

gaatttacac cttttgatgt tgttagacaa tgctcaggtg ttactttcca aagtgcagtg    10980

aaaagaacaa tcaagggtac acaccactgg ttgttactca caattttgac ttcactttta    11040

gttttagtcc agagtactca atggtctttg ttcttttttt tgtatgaaaa tgccttttta    11100

ccttttgcta tgggtattat tgctatgtct gcttttgcaa tgatgtttgt caaacataag    11160

catgcatttc tctgtttgtt tttgttacct tctcttgcca ctgtagctta ttttaatatg    11220

gtctatatgc ctgctagttg ggtgatgcgt attatgacat ggttggatat ggttgatact    11280

agtttgtctg gttttaagct aaaagactgt gttatgtatg catcagctgt agtgttacta    11340

atccttatga cagcaagaac tgtgtatgat gatggtgcta ggagagtgtg gacacttatg    11400

aatgtcttga cactcgttta taaagtttat tatggtaatg ctttagatca agccatttcc    11460

atgtgggctc ttataatctc tgttacttct aactactcag gtgtagttac aactgtcatg    11520

tttttggcca gaggtattgt ttttatgtgt gttgagtatt gccctatttt cttcataact    11580

ggtaatacac ttcagtgtat aatgctagtt tattgtttct taggctattt ttgtacttgt    11640

tactttggcc tcttttgttt actcaaccgc tactttagac tgactcttgg tgtttatgat    11700

tacttagttt ctacacagga gtttagatat atgaattcac agggactact cccacccaag    11760

aatagcatag atgccttcaa actcaacatt aaattgttgg gtgttggtgg caaaccttgt    11820

atcaaagtag ccactgtaca gtctaaaatg tcagatgtaa agtgcacatc agtagtctta    11880

ctctcagttt tgcaacaact cagagtagaa tcatcatcta aattgtgggc tcaatgtgtc    11940

cagttacaca atgacattct cttagctaaa gatactactg aagcctttga aaaaatggtt    12000

tcactacttt ctgttttgct ttccatgcag ggtgctgtag acataaacaa gctttgtgaa    12060

gaaatgctgg acaacagggc aaccttacaa gctatagcct cagagtttag ttcccttcca    12120

tcatatgcag cttttgctac tgctcaagaa gcttatgagc aggctgttgc taatggtgat    12180

tctgaagttg ttcttaaaaa gttgaagaag tctttgaatg tggctaaatc tgaatttgac    12240

cgtgatgcag ccatgcaacg taagttggaa aagatggctg atcaagctat gacccaaatg    12300

tataaacagg ctagatctga ggacaagagg gcaaaagtta ctagtgctat gcagacaatg    12360

cttttcacta tgcttagaaa gttggataat gatgcactca acaacattat caacaatgca    12420

agagatggtt gtgttccctt gaacataata cctcttacaa cagcagccaa actaatggtt    12480

gtcataccag actataacac atataaaaat acgtgtgatg gtacaacatt tacttatgca    12540

tcagcattgt gggaaatcca acaggttgta gatgcagata gtaaaattgt tcaacttagt    12600

gaaattagta tggacaattc acctaattta gcatggcctc ttattgtaac agctttaagg    12660

gccaattctg ctgtcaaatt acagaataat gagcttagtc ctgttgcact acgacagatg    12720

tcttgtgctg ccggtactac acaaactgct tgcactgatg acaatgcgtt agcttactac    12780

aacacaacaa agggaggtag gtttgtactt gcactgttat ccgatttaca ggatttgaaa    12840

tgggctagat tccctaagag tgatggaact ggtactatct atacagaact ggaaccacct    12900

tgtaggtttg ttacagacac acctaaaggt cctaaagtga agtatttata ctttattaaa    12960

ggattaaaca acctaaatag aggtatggta cttggtagtt tagctgccac agtacgtcta    13020

caagctggta atgcaacaga agtgcctgcc aattcaactg tattatcttt ctgtgctttt    13080

gctgtagatg ctgctaaagc ttacaaagat tatctagcta gtgggggaca accaatcact    13140

aattgtgtta agatgttgtg tacacacact ggtactggtc aggcaataac agttacaccg    13200

gaagccaata tggatcaaga atcctttggt ggtgcatcgt gttgtctgta ctgccgttgc    13260

cacatagatc atccaaatcc taaaggattt tgtgacttaa aaggtaagta tgtacaaata    13320

cctacaactt gtgctaatga ccctgtgggt tttacactta aaaacacagt ctgtaccgtc    13380

tgcggtatgt ggaaaggtta tggctgtagt tgtgatcaac tccgcgaacc catgcttcag    13440

tcagctgatg cacaatcgtt tttaaacggg tttgcggtgt aagtgcagcc cgtcttacac    13500

cgtgcggcac aggcactagt actgatgtcg tatacagggc ttttgacatc tacaatgata    13560

aagtagctgg ttttgctaaa ttcctaaaaa ctaattgttg tcgcttccaa gaaaaggacg    13620

aagatgacaa tttaattgat tcttactttg tagttaagag acacactttc tctaactacc    13680

aacatgaaga aacaatttat aatttactta aggattgtcc agctgttgct aaacatgact    13740

tctttaagtt tagaatagac ggtgacatgg taccacatat atcacgtcaa cgtcttacta    13800

aatacacaat ggcagacctc gtctatgctt taaggcattt tgatgaaggt aattgtgaca    13860

cattaaaaga aatacttgtc acatacaatt gttgtgatga tgattatttc aataaaaagg    13920

actggtatga ttttgtagaa aacccagata tattacgcgt atacgccaac ttaggtgaac    13980

gtgtacgcca agctttgtta aaaacagtac aattctgtga tgccatgcga aatgctggta    14040

ttgttggtgt actgacatta gataatcaag atctcaatgg taactggtat gatttcggtg    14100

atttcataca aaccacgcca ggtagtggag ttcctgttgt agattcttat tattcattgt    14160

taatgcctat attaaccttg accagggctt taactgcaga gtcacatgtt gacactgact    14220

taacaaagcc ttacattaag tgggatttgt taaaatatga cttcacggaa gagaggttaa    14280

aactctttga ccgttatttt aaatattggg atcagacata ccacccaaat tgtgttaact    14340

gtttggatga cagatgcatt ctgcattgtg caaactttaa tgttttattc tctacagtgt    14400

tcccacctac aagttttgga ccactagtga gaaaaatatt tgttgatggt gttccatttg    14460

tagtttcaac tggataccac ttcagagagc taggtgttgt acataatcag gatgtaaact    14520

tacatagctc tagacttagt tttaaggaat tacttgtgta tgctgctgac cctgctatgc    14580

acgctgcttc tggtaatcta ttactagata aacgcactac gtgcttttca gtagctgcac    14640

ttactaacaa tgttgctttt caaactgtca aacccggtaa ttttaacaaa gacttctatg    14700

actttgctgt gtctaagggt ttctttaagg aaggaagttc tgttgaatta aaacacttct    14760

tctttgctca ggatggtaat gctgctatca gcgattatga ctactatcgt tataatctac    14820

caacaatgtg tgatatcaga caactactat ttgtagttga agttgttgat aagtactttg    14880

attgttacga tggtggctgt attaatgcta accaagtcat cgtcaacaac ctagacaaat    14940

cagctggttt tccatttaat aaatggggta aggctagact ttattatgat tcaatgagtt    15000

atgaggatca agatgcactt ttcgcatata caaaacgtaa tgtcatccct actataactc    15060

aaatgaatct taagtatgcc attagtgcaa agaatagagc tcgcaccgta gctggtgtct    15120

ctatctgtag tactatgacc aatagacagt ttcatcaaaa attattgaaa tcaatagccg    15180

ccactagagg agctactgta gtaattggaa caagcaaatt ctatggtggt tggcacaaca    15240

tgttaaaaac tgtttatagt gatgtagaaa accctcacct tatgggttgg gattatccta    15300

aatgtgatag agccatgcct aacatgctta gaattatggc ctcacttgtt cttgctcgca    15360

aacatacaac gtgttgtagc ttgtcacacc gtttctatag attagctaat gagtgtgctc    15420

aagtattgag tgaaatggtc atgtgtggcg gttcactata tgttaaacca ggtggaacct    15480

catcaggaga tgccacaact gcttatgcta atagtgtttt taacatttgt caagctgtca    15540

cggccaatgt taatgcactt ttatctactg atggtaacaa aattgccgat aagtatgtcc    15600

gcaatttaca acacagactt tatgagtgtc tctatagaaa tagagatgtt gacacagact    15660

ttgtgaatga gttttacgca tatttgcgta aacatttctc aatgatgata ctctctgacg    15720

atgctgttgt gtgtttcaat agcacttatg catctcaagg tctagtggct agcataaaga    15780

actttaagtc agttctttat tatcaaaaca atgtttttat gtctgaagca aaatgttgga    15840

ctgagactga ccttactaaa ggacctcatg aattttgctc tcaacataca atgctagtta    15900

aacagggtga tgattatgtg taccttcctt acccagatcc atcaagaatc ctaggggccg    15960

gctgttttgt agatgatatc gtaaaaacag atggtacact tatgattgaa cggttcgtgt    16020

ctttagctat agatgcttac ccacttacta aacatcctaa tcaggagtat gctgatgtct    16080

ttcatttgta cttacaatac ataagaaagc tacatgatga gttaacagga cacatgttag    16140

acatgtattc tgttatgctt actaatgata acacttcaag gtattgggaa cctgagtttt    16200

atgaggctat gtacacaccg catacagtct tacaggctgt tggggcttgt gttctttgca    16260

attcacagac ttcattaaga tgtggtgctt gcatacgtag accattctta tgttgtaaat    16320

gctgttacga ccatgtcata tcaacatcac ataaattagt cttgtctgtt aatccgtatg    16380

tttgcaatgc tccaggttgt gatgtcacag atgtgactca actttactta ggaggtatga    16440

gctattattg taaatcacat aaaccaccca ttagttttcc attgtgtgct aatggacaag    16500

tttttggttt atataaaaat acatgtgttg gtagcgataa tgttactgac tttaatgcaa    16560

ttgcaacatg tgactggaca aatgctggtg attacatttt agctaacacc tgtactgaaa    16620

gactcaagct ttttgcagca gaaacgctca aagctactga ggagacattt aaactgtctt    16680

atggtattgc tactgtacgt gaagtgctgt ctgacagaga attacatctt tcatgggaag    16740

ttggtaaacc tagaccacca cttaaccgaa attatgtctt tactggttat cgtgtaacta    16800

aaaacagtaa agtacaaata ggagagtaca cctttgaaaa aggtgactat ggtgatgctg    16860

ttgtttaccg aggtacaaca acttacaaat taaatgttgg tgattatttt gtgctgacat    16920

cacatacagt aatgccatta agtgcaccta cactagtgcc acaagagcac tatgttagaa    16980

ttactggctt atacccaaca ctcaatatct cagatgagtt ttctagcaat gttgcaaatt    17040

atcaaaaggt tggtatgcaa aagtattcta cactccaggg accacctggt actggtaaga    17100

gtcattttgc tattggccta gctctctact acccttctgc tcgcatagtg tatacagctt    17160

gctctcatgc cgctgttgat gcactatgtg agaaggcatt aaaatatttg cctatagata    17220

aatgtagtag aattatacct gcacgtgctc gtgtagagtg ttttgataaa ttcaaagtga    17280

attcaacatt agaacagtat gtcttttgta ctgtaaatgc attgcctgag acgacagcag    17340

atatagttgt ctttgatgaa atttcaatgg ccacaaatta tgatttgagt gttgtcaatg    17400

ccagattacg tgctaagcac tatgtgtaca ttggcgaccc tgctcaatta cctgcaccac    17460

gcacattgct aactaagggc acactagaac cagaatattt caattcagtg tgtagactta    17520

tgaaaactat aggtccagac atgttcctcg gaacttgtcg gcgttgtcct gctgaaattg    17580

ttgacactgt gagtgctttg gtttatgata ataagcttaa agcacataaa gacaaatcag    17640

ctcaatgctt taaaatgttt tataagggtg ttatcacgca tgatgtttca tctgcaatta    17700

acaggccaca aataggcgtg gtaagagaat tccttacacg taaccctgct tggagaaaag    17760

ctgtctttat ttcaccttat aattcacaga atgctgtagc ctcaaagatt ttgggactac    17820

caactcaaac tgttgattca tcacagggct cagaatatga ctatgtcata ttcactcaaa    17880

ccactgaaac agctcactct tgtaatgtaa acagatttaa tgttgctatt accagagcaa    17940

aagtaggcat actttgcata atgtctgata gagaccttta tgacaagttg caatttacaa    18000

gtcttgaaat tccacgtagg aatgtggcaa ctttacaagc tgaaaatgta acaggactct    18060

ttaaagattg tagtaaggta atcactgggt tacatcctac acaggcacct acacacctca    18120

gtgttgacac taaattcaaa actgaaggtt tatgtgttga catacctggc atacctaagg    18180

acatgaccta tagaagactc atctctatga tgggttttaa aatgaattat caagttaatg    18240

gttaccctaa catgtttatc acccgcgaag aagctataag acatgtacgt gcatggattg    18300

gcttcgatgt cgaggggtgt catgctacta gagaagctgt tggtaccaat ttacctttac    18360

agctaggttt ttctacaggt gttaacctag ttgctgtacc tacaggttat gttgatacac    18420

ctaataatac agatttttcc agagttagtg ctaaaccacc gcctggagat caatttaaac    18480

acctcatacc acttatgtac aaaggacttc cttggaatgt agtgcgtata aagattgtac    18540

aaatgttaag tgacacactt aaaaatctct ctgacagagt cgtatttgtc ttatgggcac    18600

atggctttga gttgacatct atgaagtatt ttgtgaaaat aggacctgag cgcacctgtt    18660

gtctatgtga tagacgtgcc acatgctttt ccactgcttc agacacttat gcctgttggc    18720

atcattctat tggatttgat tacgtctata atccgtttat gattgatgtt caacaatggg    18780

gttttacagg taacctacaa agcaaccatg atctgtattg tcaagtccat ggtaatgcac    18840

atgtagctag ttgtgatgca atcatgacta ggtgtctagc tgtccacgag tgctttgtta    18900

agcgtgttga ctggactatt gaatatccta taattggtga tgaactgaag attaatgcgg    18960

cttgtagaaa ggttcaacac atggttgtta aagctgcatt attagcagac aaattcccag    19020

ttcttcacga cattggtaac cctaaagcta ttaagtgtgt acctcaagct gatgtagaat    19080

ggaagttcta tgatgcacag ccttgtagtg acaaagctta taaaatagaa gaattattct    19140

attcttatgc cacacattct gacaaattca cagatggtgt atgcctattt tggaattgca    19200

atgtcgatag atatcctgct aattccattg tttgtagatt tgacactaga gtgctatcta    19260

accttaactt gcctggttgt gatggtggca gtttgtatgt aaataaacat gcattccaca    19320

caccagcttt tgataaaagt gcttttgtta atttaaaaca attaccattt ttctattact    19380

ctgacagtcc atgtgagtct catggaaaac aagtagtgtc agatatagat tatgtaccac    19440

taaagtctgc tacgtgtata acacgttgca atttaggtgg tgctgtctgt agacatcatg    19500

ctaatgagta cagattgtat ctcgatgctt ataacatgat gatctcagct ggctttagct    19560

tgtgggttta caaacaattt gatacttata acctctggaa cacttttaca agacttcaga    19620

gtttagaaaa tgtggctttt aatgttgtaa ataagggaca ctttgatgga caacagggtg    19680

aagtaccagt ttctatcatt aataacactg tttacacaaa agttgatggt gttgatgtag    19740

aattgtttga aaataaaaca acattacctg ttaatgtagc atttgagctt tgggctaagc    19800

gcaacattaa accagtacca gaggtgaaaa tactcaataa tttgggtgtg gacattgctg    19860

ctaatactgt gatctgggac tacaaaagag atgctccagc acatatatct actattggtg    19920

tttgttctat gactgacata gccaagaaac caactgaaac gatttgtgca ccactcactg    19980

tcttttttga tggtagagtt gatggtcaag tagacttatt tagaaatgcc cgtaatggtg    20040

ttcttattac agaaggtagt gttaaaggtt tacaaccatc tgtaggtccc aaacaagcta    20100

gtcttaatgg agtcacatta attggagaag ccgtaaaaac acagttcaat tattataaga    20160

aagttgatgg tgttgtccaa caattacctg aaacttactt tactcagagt agaaatttac    20220

aagaatttaa acccaggagt caaatggaaa ttgatttctt agaattagct atggatgaat    20280

tcattgaacg gtataaatta gaaggctatg ccttcgaaca tatcgtttat ggagatttta    20340

gtcatagtca gttaggtggt ttacatctac tgattggact agctaaacgt tttaaggaat    20400

caccttttga attagaagat tttattccta tggacagtac agttaaaaac tatttcataa    20460

cagatgcgca aacaggttca tctaagtgtg tgtgttctgt tattgattta ttacttgatg    20520

attttgttga aataataaaa tcccaagatt tatctgtagt ttctaaggtt gtcaaagtga    20580

ctattgacta tacagaaatt tcatttatgc tttggtgtaa agatggccat gtagaaacat    20640

tttacccaaa attacaatct agtcaagcgt ggcaaccggg tgttgctatg cctaatcttt    20700

acaaaatgca aagaatgcta ttagaaaagt gtgaccttca aaattatggt gatagtgcaa    20760

cattacctaa aggcataatg atgaatgtcg caaaatatac tcaactgtgt caatatttaa    20820

acacattaac attagctgta ccctataata tgagagttat acattttggt gctggttctg    20880

ataaaggagt tgcaccaggt acagctgttt taagacagtg gttgcctacg ggtacgctgc    20940

ttgtcgattc agatcttaat gactttgtct ctgatgcaga ttcaactttg attggtgatt    21000

gtgcaactgt acatacagct aataaatggg atctcattat tagtgatatg tacgacccta    21060

agactaaaaa tgttacaaaa gaaaatgact ctaaagaggg ttttttcact tacatttgtg    21120

ggtttataca acaaaagcta gctcttggag gttccgtggc tataaagata acagaacatt    21180

cttggaatgc tgatctttat aagctcatgg gacacttcgc atggtggaca gcctttgtta    21240

ctaatgtgaa tgcgtcatca tctgaagcat ttttaattgg atgtaattat cttggcaaac    21300

cacgcgaaca aatagatggt tatgtcatgc atgcaaatta catattttgg aggaatacaa    21360

atccaattca gttgtcttcc tattctttat ttgacatgag taaatttccc cttaaattaa    21420

ggggtactgc tgttatgtct ttaaaagaag gtcaaatcaa tgatatgatt ttatctcttc    21480

ttagtaaagg tagacttata attagagaaa acaacagagt tgttatttct agtgatgttc    21540

ttgttaacaa ctaaacgaac aatgtttgtt tttcttgttt tattgccact agtctctagt    21600

cagtgtgtta atcttacaac cagaactcaa ttaccccctg catacactaa ttctttcaca    21660

cgtggtgttt attaccctga caaagttttc agatcctcag ttttacattc aactcaggac    21720

ttgttcttac ctttcttttc caatgttact tggttccatg ctatacatgt ctctgggacc    21780

aatggtacta agaggtttga taaccctgtc ctaccattta atgatggtgt ttattttgct    21840

tccactgaga agtctaacat aataagaggc tggatttttg gtactacttt agattcgaag    21900

acccagtccc tacttattgt taataacgct actaatgttg ttattaaagt ctgtgaattt    21960

caattttgta atgatccatt tttgggtgtt tattaccaca aaaacaacaa aagttggatg    22020

gaaagtgagt tcagagttta ttctagtgcg aataattgca cttttgaata tgtctctcag    22080

ccttttctta tggaccttga aggaaaacag ggtaatttca aaaatcttag ggaatttgtg    22140

tttaagaata ttgatggtta ttttaaaata tattctaagc acacgcctat taatttagtg    22200

cgtgatctcc ctcagggttt ttcggcttta gaaccattgg tagatttgcc aataggtatt    22260

aacatcacta ggtttcaaac tttacttgct ttacatagaa gttatttgac tcctggtgat    22320

tcttcttcag gttggacagc tggtgctgca gcttattatg tgggttatct tcaacctagg    22380

acttttctat taaaatataa tgaaaatgga accattacag atgctgtaga ctgtgcactt    22440

gaccctctct cagaaacaaa gtgtacgttg aaatccttca ctgtagaaaa aggaatctat    22500

caaacttcta actttagagt ccaaccaaca gaatctattg ttagatttcc taatattaca    22560

aacttgtgcc cttttggtga agtttttaac gccaccagat ttgcatctgt ttatgcttgg    22620

aacaggaaga gaatcagcaa ctgtgttgct gattattctg tcctatataa ttccgcatca    22680

ttttccactt ttaagtgtta tggagtgtct cctactaaat taaatgatct ctgctttact    22740

aatgtctatg cagattcatt tgtaattaga ggtgatgaag tcagacaaat cgctccaggg    22800

caaactggaa agattgctga ttataattat aaattaccag atgattttac aggctgcgtt    22860

atagcttgga attctaacaa tcttgattct aaggttggtg gtaattataa ttacctgtat    22920

agattgttta ggaagtctaa tctcaaacct tttgagagag atatttcaac tgaaatctat    22980

caggccggta gcacaccttg taatggtgtt gaaggtttta attgttactt tcctttacaa    23040

tcatatggtt tccaacccac taatggtgtt ggttaccaac catacagagt agtagtactt    23100

tcttttgaac ttctacatgc accagcaact gtttgtggac ctaaaaagtc tactaatttg    23160

gttaaaaaca aatgtgtcaa tttcaacttc aatggtttaa caggcacagg tgttcttact    23220

gagtctaaca aaaagtttct gcctttccaa caatttggca gagacattgc tgacactact    23280

gatgctgtcc gtgatccaca gacacttgag attcttgaca ttacaccatg ttcttttggt    23340

ggtgtcagtg ttataacacc aggaacaaat acttctaacc aggttgctgt tctttatcag    23400

gatgttaact gcacagaagt ccctgttgct attcatgcag atcaacttac tcctacttgg    23460

cgtgtttatt ctacaggttc taatgttttt caaacacgtg caggctgttt aataggggct    23520

gaacatgtca acaactcata tgagtgtgac atacccattg gtgcaggtat atgcgctagt    23580

tatcagactc agactaattc tcctcggcgg gcacgtagtg tagctagtca atccatcatt    23640

gcctacacta tgtcacttgg tgcagaaaat tcagttgctt actctaataa ctctattgcc    23700

atacccacaa attttactat tagtgttacc acagaaattc taccagtgtc tatgaccaag    23760

acatcagtag attgtacaat gtacatttgt ggtgattcaa ctgaatgcag caatcttttg    23820

ttgcaatatg gcagtttttg tacacaatta aaccgtgctt taactggaat agctgttgaa    23880

caagacaaaa acacccaaga agtttttgca caagtcaaac aaatttacaa aacaccacca    23940

attaaagatt ttggtggttt taatttttca caaatattac cagatccatc aaaaccaagc    24000

aagaggtcat ttattgaaga tctacttttc aacaaagtga cacttgcaga tgctggcttc    24060

atcaaacaat atggtgattg ccttggtgat attgctgcta gagacctcat ttgtgcacaa    24120

aagtttaacg gccttactgt tttgccacct ttgctcacag atgaaatgat tgctcaatac    24180

acttctgcac tgttagcggg tacaatcact tctggttgga cctttggtgc aggtgctgca    24240

ttacaaatac catttgctat gcaaatggct tataggttta atggtattgg agttacacag    24300

aatgttctct atgagaacca aaaattgatt gccaaccaat ttaatagtgc tattggcaaa    24360

attcaagact cactttcttc cacagcaagt gcacttggaa aacttcaaga tgtggtcaac    24420

caaaatgcac aagctttaaa cacgcttgtt aaacaactta gctccaattt tggtgcaatt    24480

tcaagtgttt taaatgatat cctttcacgt cttgacaaag ttgaggctga agtgcaaatt    24540

gataggttga tcacaggcag acttcaaagt ttgcagacat atgtgactca acaattaatt    24600

agagctgcag aaatcagagc ttctgctaat cttgctgcta ctaaaatgtc agagtgtgta    24660

cttggacaat caaaaagagt tgatttttgt ggaaagggct atcatcttat gtccttccct    24720

cagtcagcac ctcatggtgt agtcttcttg catgtgactt atgtccctgc acaagaaaag    24780

aacttcacaa ctgctcctgc catttgtcat gatggaaaag cacactttcc tcgtgaaggt    24840

gtctttgttt caaatggcac acactggttt gtaacacaaa ggaattttta tgaaccacaa    24900

atcattacta cagacaacac atttgtgtct ggtaactgtg atgttgtaat aggaattgtc    24960

aacaacacag tttatgatcc tttgcaacct gaattagact cattcaagga ggagttagat    25020

aaatatttta agaatcatac atcaccagat gttgatttag gtgacatctc tggcattaat    25080

gcttcagttg taaacattca aaaagaaatt gaccgcctca atgaggttgc caagaattta    25140

aatgaatctc tcatcgatct ccaagaactt ggaaagtatg agcagtatat aaaatggcca    25200

tggtacattt ggctaggttt tatagctggc ttgattgcca tagtaatggt gacaattatg    25260

ctttgctgta tgaccagttg ctgtagttgt ctcaagggct gttgttcttg tggatcctgc    25320

tgcaaatttg atgaagacga ctctgagcca gtgctcaaag gagtcaaatt acattacaca    25380

taaacgaact tatggatttg tttatgagaa tcttcacaat tggaactgta actttgaagc    25440

aaggtgaaat caaggatgct actccttcag attttgttcg cgctactgca acgataccga    25500

tacaagcctc actccctttc ggatggctta ttgttggcgt tgcacttctt gctgtttttc    25560

agagcgcttc caaaatcata accctcaaaa agagatggca actagcactc tccaagggtg    25620

ttcactttgt ttgcaacttg ctgttgttgt ttgtaacagt ttactcacac cttttgctcg    25680

ttgctgctgg ccttgaagcc ccttttctct atctttatgc tttagtctac ttcttgcaga    25740

gtataaactt tgtaagaata ataatgaggc tttggctttg ctggaaatgc cgttccaaaa    25800

acccattact ttatgatgcc aactattttc tttgctggca tactaattgt tacgactatt    25860

gtatacctta caatagtgta acttcttcaa ttgtcattac ttcaggtgat ggcacaacaa    25920

gtcctatttc tgaacatgac taccagattg gtggttatac tgaaaaatgg gaatctggag    25980

taaaagactg tgttgtatta cacagttact tcacttcaga ctattaccag ctgtactcaa    26040

ctcaattgag tacagacact ggtgttgaac atgttacctt cttcatctac aataaaattg    26100

ttgatgagcc tgaagaacat gtccaaattc acacaatcga cggttcatcc ggagttgtta    26160

atccagtaat ggaaccaatt tatgatgaac cgacgacgac tactagcgtg cctttgtaag    26220

cacaagctga tgagtacgaa cttatgtact cattcgtttc ggaagagaca ggtacgttaa    26280

tagttaatag cgtacttctt tttcttgctt tcgtggtatt cttgctagtt acactagcca    26340

tccttactgc gcttcgattg tgtgcgtact gctgcaatat tgttaacgtg agtcttgtaa    26400

aaccttcttt ttacgtttac tctcgtgtta aaaatctgaa ttcttctaga gttcctgatc    26460

ttctggtcta aacgaactaa atattatatt agtttttctg tttggaactt taattttagc    26520

catggcagat tccaacggta ctattaccgt tgaagagctt aaaaagctcc ttgaacaatg    26580

gaacctagta ataggtttcc tattccttac atggatttgt cttctacaat ttgcctatgc    26640

caacaggaat aggtttttgt atataattaa gttaattttc ctctggctgt tatggccagt    26700

aactttagct tgttttgtgc ttgctgctgt ttacagaata aattggatca ccggtggaat    26760

tgctatcgca atggcttgtc ttgtaggctt gatgtggctc agctacttca ttgcttcttt    26820

cagactgttt gcgcgtacgc gttccatgtg gtcattcaat ccagaaacta acattcttct    26880

caacgtgcca ctccatggca ctattctgac cagaccgctt ctagaaagtg aactcgtaat    26940

cggagctgtg atccttcgtg gacatcttcg tattgctgga caccatctag gacgctgtga    27000

catcaaggac ctgcctaaag aaatcactgt tgctacatca cgaacgcttt cttattacaa    27060

attgggagct tcgcagcgtg tagcaggtga ctcaggtttt gctgcataca gtcgctacag    27120

gattggcaac tataaattaa acacagacca ttccagtagc agtgacaata ttgctttgct    27180

tgtacagtaa gtgacaacag atgtttcatc tcgttgactt tcaggttact atagcagaga    27240

tattactaat tattatgagg acttttaaag tttccatttg gaatcttgat tacatcataa    27300

acctcataat taaaaattta tctaagtcac taactgagaa taaatattct caattagatg    27360

aagagcaacc aatggagatt gattaaacga acatgaaaat tattcttttc ttggcactga    27420

taacactcgc tacttgtgag ctttatcact accaagagtg tgttagaggt acaacagtac    27480

ttttaaaaga accttgctct tctggaacat acgagggcaa ttcaccattt catcctctag    27540

ctgataacaa atttgcactg acttgcttta gcactcaatt tgcttttgct tgtcctgacg    27600

gcgtaaaaca cgtctatcag ttacgtgcca gatcagtttc acctaaactg ttcatcagac    27660

aagaggaagt tcaagaactt tactctccaa tttttcttat tgttgcggca atagtgttta    27720

taacactttg cttcacactc aaaagaaaga cagaatgatt gaactttcat taattgactt    27780

ctatttgtgc tttttagcct ttctgctatt ccttgtttta attatgctta ttatcttttg    27840

gttctcactt gaactgcaag atcataatga aacttgtcac gcctaaacga acatgaaatt    27900

tcttgttttc ttaggaatca tcacaactgt agctgcattt caccaagaat gtagtttaca    27960

gtcatgtact caacatcaac catatgtagt tgatgacccg tgtcctattc acttctattc    28020

taaatggtat attagagtag gagctagaaa atcagcacct ttaattgaat tgtgcgtgga    28080

tgaggctggt tctaaatcac ccattcagta catcgatatc ggtaattata cagtttcctg    28140

tttacctttt acaattaatt gccaggaacc taaattgggt agtcttgtag tgcgttgttc    28200

gttctatgaa gactttttag agtatcatga cgttcgtgtt gttttagatt tcatctaaac    28260

gaacaaacta aaatgtctga taatggaccc caaaatcagc gaaatgcacc ccgcattacg    28320

tttggtggac cctcagattc aactggcagt aaccagaatg gagaacgcag tggggcgcga    28380

tcaaaacaac gtcggcccca aggtttaccc aataatactg cgtcttggtt caccgctctc    28440

actcaacatg gcaaggaaga ccttaaattc cctcgaggac aaggcgttcc aattaacacc    28500

aatagcagtc cagatgacca aattggctac taccgaagag ctaccagacg aattcgtggt    28560

ggtgacggta aaatgaaaga tctcagtcca agatggtatt tctactacct aggaactggg    28620

ccagaagctg gacttcccta tggtgctaac aaagacggca tcatatgggt tgcaactgag    28680

ggagccttga atacaccaaa agatcacatt ggcacccgca atcctgctaa caatgctgca    28740

atcgtgctac aacttcctca aggaacaaca ttgccaaaag gcttctacgc agaagggagc    28800

agaggcggca gtcaagcctc ttctcgttcc tcatcacgta gtcgcaacag ttcaagaaat    28860

tcaactccag gcagcagtag gggaacttct cctgctagaa tggctggcaa tggcggtgat    28920

gctgctcttg ctttgctgct gcttgacaga ttgaaccagc ttgagagcaa aatgtctggt    28980

aaaggccaac aacaacaagg ccaaactgtc actaagaaat ctgctgctga ggcttctaag    29040

aagcctcggc aaaaacgtac tgccactaaa gcatacaatg taacacaagc tttcggcaga    29100

cgtggtccag aacaaaccca aggaaatttt ggggaccagg aactaatcag acaaggaact    29160

gattacaaac attggccgca aattgcacaa tttgccccca gcgcttcagc gttcttcgga    29220

atgtcgcgca ttggcatgga agtcacacct tcgggaacgt ggttgaccta cacaggtgcc    29280

atcaaattgg atgacaaaga tccaaatttc aaagatcaag tcattttgct gaataagcat    29340

attgacgcat acaaaacatt cccaccaaca gagcctaaaa aggacaaaaa gaagaaggct    29400

gatgaaactc aagccttacc gcagagacag aagaaacagc aaactgtgac tcttcttcct    29460

gctgcagatt tggatgattt ctccaaacaa ttgcaacaat ccatgagcag tgctgactca    29520

actcaggcct aaactcatgc agaccacaca aggcagatgg gctatataaa cgttttcgct    29580

tttccgttta cgatatatag tctactcttg tgcagaatga attctcgtaa ctacatagca    29640

caagtagatg tagttaactt taatctcaca tagcaatctt taatcagtgt gtaacattag    29700

ggaggacttg aaagagccac cacattttca ccgaggccac gcggagtacg atcgagtgta    29760

cagtgaacaa tgctagggag agctgcctat atggaagagc cctaatgtgt aaaattaatt    29820

ttagtagtgc tatccccatg tgattttaat agcttcttag gagaatgaca aaaaaaaaaa    29880

aaaaaaaaaa aaaaaaaaaa aa                                             29902


<210>  2
<211>  7096
<212>  PRT
<213>  SARS-CoV-2 beta

<400>  2

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu 
1               5                   10                  15      


Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly 
            20                  25                  30          


Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp 
        35                  40                  45              


Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu 
    50                  55                  60                  


Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro 
65                  70                  75                  80  


His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln 
                85                  90                  95      


Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly 
            100                 105                 110         


Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn 
        115                 120                 125             


Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp 
    130                 135                 140                 


Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn 
145                 150                 155                 160 


Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu 
                165                 170                 175     


Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly 
            180                 185                 190         


Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala 
        195                 200                 205             


Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr 
    210                 215                 220                 


Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp 
225                 230                 235                 240 


Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu 
                245                 250                 255     


Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn 
            260                 265                 270         


Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val 
        275                 280                 285             


Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr 
    290                 295                 300                 


Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu 
305                 310                 315                 320 


Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe 
                325                 330                 335     


Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu 
            340                 345                 350         


Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile 
        355                 360                 365             


Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu 
    370                 375                 380                 


Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly 
385                 390                 395                 400 


Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys 
                405                 410                 415     


His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly 
            420                 425                 430         


Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp 
        435                 440                 445             


Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val 
    450                 455                 460                 


Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe 
465                 470                 475                 480 


Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr 
                485                 490                 495     


Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr 
            500                 505                 510         


Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser 
        515                 520                 525             


Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val 
    530                 535                 540                 


Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg 
545                 550                 555                 560 


Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr 
                565                 570                 575     


Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr 
            580                 585                 590         


Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu 
        595                 600                 605             


Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu 
    610                 615                 620                 


Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu 
625                 630                 635                 640 


Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala 
                645                 650                 655     


Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys 
            660                 665                 670         


Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu 
        675                 680                 685             


Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn 
    690                 695                 700                 


Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys 
705                 710                 715                 720 


Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro 
                725                 730                 735     


Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu 
            740                 745                 750         


Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln 
        755                 760                 765             


Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys 
    770                 775                 780                 


Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys 
785                 790                 795                 800 


Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys 
                805                 810                 815     


Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu 
            820                 825                 830         


Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg 
        835                 840                 845             


Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu 
    850                 855                 860                 


Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile 
865                 870                 875                 880 


Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp 
                885                 890                 895     


Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly 
            900                 905                 910         


Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp 
        915                 920                 925             


Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser 
    930                 935                 940                 


Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu 
945                 950                 955                 960 


Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu 
                965                 970                 975     


Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp 
            980                 985                 990         


Gly Ser Glu Asp Asn Gln Thr Thr  Thr Ile Gln Thr Ile  Val Glu Val 
        995                 1000                 1005             


Gln Pro  Gln Leu Glu Met Glu  Leu Thr Pro Val Val  Gln Thr Ile 
    1010                 1015                 1020             


Glu Val  Asn Ser Phe Ser Gly  Tyr Leu Lys Leu Thr  Asp Asn Val 
    1025                 1030                 1035             


Tyr Ile  Lys Asn Ala Asp Ile  Val Glu Glu Ala Lys  Lys Val Lys 
    1040                 1045                 1050             


Pro Thr  Val Val Val Asn Ala  Ala Asn Val Tyr Leu  Lys His Gly 
    1055                 1060                 1065             


Gly Gly  Val Ala Gly Ala Leu  Asn Lys Ala Thr Asn  Asn Ala Met 
    1070                 1075                 1080             


Gln Val  Glu Ser Asp Asp Tyr  Ile Ala Thr Asn Gly  Pro Leu Lys 
    1085                 1090                 1095             


Val Gly  Gly Ser Cys Val Leu  Ser Gly His Asn Leu  Ala Lys His 
    1100                 1105                 1110             


Cys Leu  His Val Val Gly Pro  Asn Val Asn Lys Gly  Glu Asp Ile 
    1115                 1120                 1125             


Gln Leu  Leu Lys Ser Ala Tyr  Glu Asn Phe Asn Gln  His Glu Val 
    1130                 1135                 1140             


Leu Leu  Ala Pro Leu Leu Ser  Ala Gly Ile Phe Gly  Ala Asp Pro 
    1145                 1150                 1155             


Ile His  Ser Leu Arg Val Cys  Val Asp Thr Val Arg  Thr Asn Val 
    1160                 1165                 1170             


Tyr Leu  Ala Val Phe Asp Lys  Asn Leu Tyr Asp Lys  Leu Val Ser 
    1175                 1180                 1185             


Ser Phe  Leu Glu Met Lys Ser  Glu Lys Gln Val Glu  Gln Lys Ile 
    1190                 1195                 1200             


Ala Glu  Ile Pro Lys Glu Glu  Val Lys Pro Phe Ile  Thr Glu Ser 
    1205                 1210                 1215             


Lys Pro  Ser Val Glu Gln Arg  Lys Gln Asp Asp Lys  Lys Ile Lys 
    1220                 1225                 1230             


Ala Cys  Val Glu Glu Val Thr  Thr Thr Leu Glu Glu  Thr Lys Phe 
    1235                 1240                 1245             


Leu Thr  Glu Asn Leu Leu Leu  Tyr Ile Asp Ile Asn  Gly Asn Leu 
    1250                 1255                 1260             


His Pro  Asp Ser Ala Thr Leu  Val Ser Asp Ile Asp  Ile Thr Phe 
    1265                 1270                 1275             


Leu Lys  Lys Asp Ala Pro Tyr  Ile Val Gly Asp Val  Val Gln Glu 
    1280                 1285                 1290             


Gly Val  Leu Thr Ala Val Val  Ile Pro Thr Lys Lys  Ala Gly Gly 
    1295                 1300                 1305             


Thr Thr  Glu Met Leu Ala Lys  Ala Leu Arg Lys Val  Pro Thr Asp 
    1310                 1315                 1320             


Asn Tyr  Ile Thr Thr Tyr Pro  Gly Gln Gly Leu Asn  Gly Tyr Thr 
    1325                 1330                 1335             


Val Glu  Glu Ala Lys Thr Val  Leu Lys Lys Cys Lys  Ser Ala Phe 
    1340                 1345                 1350             


Tyr Ile  Leu Pro Ser Ile Ile  Ser Asn Glu Lys Gln  Glu Ile Leu 
    1355                 1360                 1365             


Gly Thr  Val Ser Trp Asn Leu  Arg Glu Met Leu Ala  His Ala Glu 
    1370                 1375                 1380             


Glu Thr  Arg Lys Leu Met Pro  Val Cys Val Glu Thr  Lys Ala Ile 
    1385                 1390                 1395             


Val Ser  Thr Ile Gln Arg Lys  Tyr Lys Gly Ile Lys  Ile Gln Glu 
    1400                 1405                 1410             


Gly Val  Val Asp Tyr Gly Ala  Arg Phe Tyr Phe Tyr  Thr Ser Lys 
    1415                 1420                 1425             


Thr Thr  Val Ala Ser Leu Ile  Asn Thr Leu Asn Asp  Leu Asn Glu 
    1430                 1435                 1440             


Thr Leu  Val Thr Met Pro Leu  Gly Tyr Val Thr His  Gly Leu Asn 
    1445                 1450                 1455             


Leu Glu  Glu Ala Ala Arg Tyr  Met Arg Ser Leu Lys  Val Pro Ala 
    1460                 1465                 1470             


Thr Val  Ser Val Ser Ser Pro  Asp Ala Val Thr Ala  Tyr Asn Gly 
    1475                 1480                 1485             


Tyr Leu  Thr Ser Ser Ser Lys  Thr Pro Glu Glu His  Phe Ile Glu 
    1490                 1495                 1500             


Thr Ile  Ser Leu Ala Gly Ser  Tyr Lys Asp Trp Ser  Tyr Ser Gly 
    1505                 1510                 1515             


Gln Ser  Thr Gln Leu Gly Ile  Glu Phe Leu Lys Arg  Gly Asp Lys 
    1520                 1525                 1530             


Ser Val  Tyr Tyr Thr Ser Asn  Pro Thr Thr Phe His  Leu Asp Gly 
    1535                 1540                 1545             


Glu Val  Ile Thr Phe Asp Asn  Leu Lys Thr Leu Leu  Ser Leu Arg 
    1550                 1555                 1560             


Glu Val  Arg Thr Ile Lys Val  Phe Thr Thr Val Asp  Asn Ile Asn 
    1565                 1570                 1575             


Leu His  Thr Gln Val Val Asp  Met Ser Met Thr Tyr  Gly Gln Gln 
    1580                 1585                 1590             


Phe Gly  Pro Thr Tyr Leu Asp  Gly Ala Asp Val Thr  Lys Ile Lys 
    1595                 1600                 1605             


Pro His  Asn Ser His Glu Gly  Lys Thr Phe Tyr Val  Leu Pro Asn 
    1610                 1615                 1620             


Asp Asp  Thr Leu Arg Val Glu  Ala Phe Glu Tyr Tyr  His Thr Thr 
    1625                 1630                 1635             


Asp Pro  Ser Phe Leu Gly Arg  Tyr Met Ser Ala Leu  Asn His Thr 
    1640                 1645                 1650             


Lys Lys  Trp Lys Tyr Pro Gln  Val Asn Gly Leu Thr  Ser Ile Lys 
    1655                 1660                 1665             


Trp Ala  Asp Asn Asn Cys Tyr  Leu Ala Thr Ala Leu  Leu Thr Leu 
    1670                 1675                 1680             


Gln Gln  Ile Glu Leu Lys Phe  Asn Pro Pro Ala Leu  Gln Asp Ala 
    1685                 1690                 1695             


Tyr Tyr  Arg Ala Arg Ala Gly  Glu Ala Ala Asn Phe  Cys Ala Leu 
    1700                 1705                 1710             


Ile Leu  Ala Tyr Cys Asn Lys  Thr Val Gly Glu Leu  Gly Asp Val 
    1715                 1720                 1725             


Arg Glu  Thr Met Ser Tyr Leu  Phe Gln His Ala Asn  Leu Asp Ser 
    1730                 1735                 1740             


Cys Lys  Arg Val Leu Asn Val  Val Cys Lys Thr Cys  Gly Gln Gln 
    1745                 1750                 1755             


Gln Thr  Thr Leu Lys Gly Val  Glu Ala Val Met Tyr  Met Gly Thr 
    1760                 1765                 1770             


Leu Ser  Tyr Glu Gln Phe Lys  Lys Gly Val Gln Ile  Pro Cys Thr 
    1775                 1780                 1785             


Cys Gly  Lys Gln Ala Thr Lys  Tyr Leu Val Gln Gln  Glu Ser Pro 
    1790                 1795                 1800             


Phe Val  Met Met Ser Ala Pro  Pro Ala Gln Tyr Glu  Leu Lys His 
    1805                 1810                 1815             


Gly Thr  Phe Thr Cys Ala Ser  Glu Tyr Thr Gly Asn  Tyr Gln Cys 
    1820                 1825                 1830             


Gly His  Tyr Lys His Ile Thr  Ser Lys Glu Thr Leu  Tyr Cys Ile 
    1835                 1840                 1845             


Asp Gly  Ala Leu Leu Thr Lys  Ser Ser Glu Tyr Lys  Gly Pro Ile 
    1850                 1855                 1860             


Thr Asp  Val Phe Tyr Lys Glu  Asn Ser Tyr Thr Thr  Thr Ile Lys 
    1865                 1870                 1875             


Pro Val  Thr Tyr Lys Leu Asp  Gly Val Val Cys Thr  Glu Ile Asp 
    1880                 1885                 1890             


Pro Lys  Leu Asp Asn Tyr Tyr  Lys Lys Asp Asn Ser  Tyr Phe Thr 
    1895                 1900                 1905             


Glu Gln  Pro Ile Asp Leu Val  Pro Asn Gln Pro Tyr  Pro Asn Ala 
    1910                 1915                 1920             


Ser Phe  Asp Asn Phe Lys Phe  Val Cys Asp Asn Ile  Lys Phe Ala 
    1925                 1930                 1935             


Asp Asp  Leu Asn Gln Leu Thr  Gly Tyr Lys Lys Pro  Ala Ser Arg 
    1940                 1945                 1950             


Glu Leu  Lys Val Thr Phe Phe  Pro Asp Leu Asn Gly  Asp Val Val 
    1955                 1960                 1965             


Ala Ile  Asp Tyr Lys His Tyr  Thr Pro Ser Phe Lys  Lys Gly Ala 
    1970                 1975                 1980             


Lys Leu  Leu His Lys Pro Ile  Val Trp His Val Asn  Asn Ala Thr 
    1985                 1990                 1995             


Asn Lys  Ala Thr Tyr Lys Pro  Asn Thr Trp Cys Ile  Arg Cys Leu 
    2000                 2005                 2010             


Trp Ser  Thr Lys Pro Val Glu  Thr Ser Asn Ser Phe  Asp Val Leu 
    2015                 2020                 2025             


Lys Ser  Glu Asp Ala Gln Gly  Met Asp Asn Leu Ala  Cys Glu Asp 
    2030                 2035                 2040             


Leu Lys  Pro Val Ser Glu Glu  Val Val Glu Asn Pro  Thr Ile Gln 
    2045                 2050                 2055             


Lys Asp  Val Leu Glu Cys Asn  Val Lys Thr Thr Glu  Val Val Gly 
    2060                 2065                 2070             


Asp Ile  Ile Leu Lys Pro Ala  Asn Asn Ser Leu Lys  Ile Thr Glu 
    2075                 2080                 2085             


Glu Val  Gly His Thr Asp Leu  Met Ala Ala Tyr Val  Asp Asn Ser 
    2090                 2095                 2100             


Ser Leu  Thr Ile Lys Lys Pro  Asn Glu Leu Ser Arg  Val Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Leu Ala Thr His  Gly Leu Ala Ala Val  Asn Ser Val 
    2120                 2125                 2130             


Pro Trp  Asp Thr Ile Ala Asn  Tyr Ala Lys Pro Phe  Leu Asn Lys 
    2135                 2140                 2145             


Val Val  Ser Thr Thr Thr Asn  Ile Val Thr Arg Cys  Leu Asn Arg 
    2150                 2155                 2160             


Val Cys  Thr Asn Tyr Met Pro  Tyr Phe Phe Thr Leu  Leu Leu Gln 
    2165                 2170                 2175             


Leu Cys  Thr Phe Thr Arg Ser  Thr Asn Ser Arg Ile  Lys Ala Ser 
    2180                 2185                 2190             


Met Pro  Thr Thr Ile Ala Lys  Asn Thr Val Lys Ser  Val Gly Lys 
    2195                 2200                 2205             


Phe Cys  Leu Glu Ala Ser Phe  Asn Tyr Leu Lys Ser  Pro Asn Phe 
    2210                 2215                 2220             


Ser Lys  Leu Ile Asn Ile Ile  Ile Trp Phe Leu Leu  Leu Ser Val 
    2225                 2230                 2235             


Cys Leu  Gly Ser Leu Ile Tyr  Ser Thr Ala Ala Leu  Gly Val Leu 
    2240                 2245                 2250             


Met Ser  Asn Leu Gly Met Pro  Ser Tyr Cys Thr Gly  Tyr Arg Glu 
    2255                 2260                 2265             


Gly Tyr  Leu Asn Ser Thr Asn  Val Thr Ile Ala Thr  Tyr Cys Thr 
    2270                 2275                 2280             


Gly Ser  Ile Pro Cys Ser Val  Cys Leu Ser Gly Leu  Asp Ser Leu 
    2285                 2290                 2295             


Asp Thr  Tyr Pro Ser Leu Glu  Thr Ile Gln Ile Thr  Ile Ser Ser 
    2300                 2305                 2310             


Phe Lys  Trp Asp Leu Thr Ala  Phe Gly Leu Val Ala  Glu Trp Phe 
    2315                 2320                 2325             


Leu Ala  Tyr Ile Leu Phe Thr  Arg Phe Phe Tyr Val  Leu Gly Leu 
    2330                 2335                 2340             


Ala Ala  Ile Met Gln Leu Phe  Phe Ser Tyr Phe Ala  Val His Phe 
    2345                 2350                 2355             


Ile Ser  Asn Ser Trp Leu Met  Trp Leu Ile Ile Asn  Leu Val Gln 
    2360                 2365                 2370             


Met Ala  Pro Ile Ser Ala Met  Val Arg Met Tyr Ile  Phe Phe Ala 
    2375                 2380                 2385             


Ser Phe  Tyr Tyr Val Trp Lys  Ser Tyr Val His Val  Val Asp Gly 
    2390                 2395                 2400             


Cys Asn  Ser Ser Thr Cys Met  Met Cys Tyr Lys Arg  Asn Arg Ala 
    2405                 2410                 2415             


Thr Arg  Val Glu Cys Thr Thr  Ile Val Asn Gly Val  Arg Arg Ser 
    2420                 2425                 2430             


Phe Tyr  Val Tyr Ala Asn Gly  Gly Lys Gly Phe Cys  Lys Leu His 
    2435                 2440                 2445             


Asn Trp  Asn Cys Val Asn Cys  Asp Thr Phe Cys Ala  Gly Ser Thr 
    2450                 2455                 2460             


Phe Ile  Ser Asp Glu Val Ala  Arg Asp Leu Ser Leu  Gln Phe Lys 
    2465                 2470                 2475             


Arg Pro  Ile Asn Pro Thr Asp  Gln Ser Ser Tyr Ile  Val Asp Ser 
    2480                 2485                 2490             


Val Thr  Val Lys Asn Gly Ser  Ile His Leu Tyr Phe  Asp Lys Ala 
    2495                 2500                 2505             


Gly Gln  Lys Thr Tyr Glu Arg  His Ser Leu Ser His  Phe Val Asn 
    2510                 2515                 2520             


Leu Asp  Asn Leu Arg Ala Asn  Asn Thr Lys Gly Ser  Leu Pro Ile 
    2525                 2530                 2535             


Asn Val  Ile Val Phe Asp Gly  Lys Ser Lys Cys Glu  Glu Ser Ser 
    2540                 2545                 2550             


Ala Lys  Ser Ala Ser Val Tyr  Tyr Ser Gln Leu Met  Cys Gln Pro 
    2555                 2560                 2565             


Ile Leu  Leu Leu Asp Gln Ala  Leu Val Ser Asp Val  Gly Asp Ser 
    2570                 2575                 2580             


Ala Glu  Val Ala Val Lys Met  Phe Asp Ala Tyr Val  Asn Thr Phe 
    2585                 2590                 2595             


Ser Ser  Thr Phe Asn Val Pro  Met Glu Lys Leu Lys  Thr Leu Val 
    2600                 2605                 2610             


Ala Thr  Ala Glu Ala Glu Leu  Ala Lys Asn Val Ser  Leu Asp Asn 
    2615                 2620                 2625             


Val Leu  Ser Thr Phe Ile Ser  Ala Ala Arg Gln Gly  Phe Val Asp 
    2630                 2635                 2640             


Ser Asp  Val Glu Thr Lys Asp  Val Val Glu Cys Leu  Lys Leu Ser 
    2645                 2650                 2655             


His Gln  Ser Asp Ile Glu Val  Thr Gly Asp Ser Cys  Asn Asn Tyr 
    2660                 2665                 2670             


Met Leu  Thr Tyr Asn Lys Val  Glu Asn Met Thr Pro  Arg Asp Leu 
    2675                 2680                 2685             


Gly Ala  Cys Ile Asp Cys Ser  Ala Arg His Ile Asn  Ala Gln Val 
    2690                 2695                 2700             


Ala Lys  Ser His Asn Ile Ala  Leu Ile Trp Asn Val  Lys Asp Phe 
    2705                 2710                 2715             


Met Ser  Leu Ser Glu Gln Leu  Arg Lys Gln Ile Arg  Ser Ala Ala 
    2720                 2725                 2730             


Lys Lys  Asn Asn Leu Pro Phe  Lys Leu Thr Cys Ala  Thr Thr Arg 
    2735                 2740                 2745             


Gln Val  Val Asn Val Val Thr  Thr Lys Ile Ala Leu  Lys Gly Gly 
    2750                 2755                 2760             


Lys Ile  Val Asn Asn Trp Leu  Lys Gln Leu Ile Lys  Val Thr Leu 
    2765                 2770                 2775             


Val Phe  Leu Phe Val Ala Ala  Ile Phe Tyr Leu Ile  Thr Pro Val 
    2780                 2785                 2790             


His Val  Met Ser Lys His Thr  Asp Phe Ser Ser Glu  Ile Ile Gly 
    2795                 2800                 2805             


Tyr Lys  Ala Ile Asp Gly Gly  Val Thr Arg Asp Ile  Ala Ser Thr 
    2810                 2815                 2820             


Asp Thr  Cys Phe Ala Asn Lys  His Ala Asp Phe Asp  Thr Trp Phe 
    2825                 2830                 2835             


Ser Gln  Arg Gly Gly Ser Tyr  Thr Asn Asp Lys Ala  Cys Pro Leu 
    2840                 2845                 2850             


Ile Ala  Ala Val Ile Thr Arg  Glu Val Gly Phe Val  Val Pro Gly 
    2855                 2860                 2865             


Leu Pro  Gly Thr Ile Leu Arg  Thr Thr Asn Gly Asp  Phe Leu His 
    2870                 2875                 2880             


Phe Leu  Pro Arg Val Phe Ser  Ala Val Gly Asn Ile  Cys Tyr Thr 
    2885                 2890                 2895             


Pro Ser  Lys Leu Ile Glu Tyr  Thr Asp Phe Ala Thr  Ser Ala Cys 
    2900                 2905                 2910             


Val Leu  Ala Ala Glu Cys Thr  Ile Phe Lys Asp Ala  Ser Gly Lys 
    2915                 2920                 2925             


Pro Val  Pro Tyr Cys Tyr Asp  Thr Asn Val Leu Glu  Gly Ser Val 
    2930                 2935                 2940             


Ala Tyr  Glu Ser Leu Arg Pro  Asp Thr Arg Tyr Val  Leu Met Asp 
    2945                 2950                 2955             


Gly Ser  Ile Ile Gln Phe Pro  Asn Thr Tyr Leu Glu  Gly Ser Val 
    2960                 2965                 2970             


Arg Val  Val Thr Thr Phe Asp  Ser Glu Tyr Cys Arg  His Gly Thr 
    2975                 2980                 2985             


Cys Glu  Arg Ser Glu Ala Gly  Val Cys Val Ser Thr  Ser Gly Arg 
    2990                 2995                 3000             


Trp Val  Leu Asn Asn Asp Tyr  Tyr Arg Ser Leu Pro  Gly Val Phe 
    3005                 3010                 3015             


Cys Gly  Val Asp Ala Val Asn  Leu Leu Thr Asn Met  Phe Thr Pro 
    3020                 3025                 3030             


Leu Ile  Gln Pro Ile Gly Ala  Leu Asp Ile Ser Ala  Ser Ile Val 
    3035                 3040                 3045             


Ala Gly  Gly Ile Val Ala Ile  Val Val Thr Cys Leu  Ala Tyr Tyr 
    3050                 3055                 3060             


Phe Met  Arg Phe Arg Arg Ala  Phe Gly Glu Tyr Ser  His Val Val 
    3065                 3070                 3075             


Ala Phe  Asn Thr Leu Leu Phe  Leu Met Ser Phe Thr  Val Leu Cys 
    3080                 3085                 3090             


Leu Thr  Pro Val Tyr Ser Phe  Leu Pro Gly Val Tyr  Ser Val Ile 
    3095                 3100                 3105             


Tyr Leu  Tyr Leu Thr Phe Tyr  Leu Thr Asn Asp Val  Ser Phe Leu 
    3110                 3115                 3120             


Ala His  Ile Gln Trp Met Val  Met Phe Thr Pro Leu  Val Pro Phe 
    3125                 3130                 3135             


Trp Ile  Thr Ile Ala Tyr Ile  Ile Cys Ile Ser Thr  Lys His Phe 
    3140                 3145                 3150             


Tyr Trp  Phe Phe Ser Asn Tyr  Leu Lys Arg Arg Val  Val Phe Asn 
    3155                 3160                 3165             


Gly Val  Ser Phe Ser Thr Phe  Glu Glu Ala Ala Leu  Cys Thr Phe 
    3170                 3175                 3180             


Leu Leu  Asn Lys Glu Met Tyr  Leu Lys Leu Arg Ser  Asp Val Leu 
    3185                 3190                 3195             


Leu Pro  Leu Thr Gln Tyr Asn  Arg Tyr Leu Ala Leu  Tyr Asn Lys 
    3200                 3205                 3210             


Tyr Lys  Tyr Phe Ser Gly Ala  Met Asp Thr Thr Ser  Tyr Arg Glu 
    3215                 3220                 3225             


Ala Ala  Cys Cys His Leu Ala  Lys Ala Leu Asn Asp  Phe Ser Asn 
    3230                 3235                 3240             


Ser Gly  Ser Asp Val Leu Tyr  Gln Pro Pro Gln Thr  Ser Ile Thr 
    3245                 3250                 3255             


Ser Ala  Val Leu Gln Ser Gly  Phe Arg Lys Met Ala  Phe Pro Ser 
    3260                 3265                 3270             


Gly Lys  Val Glu Gly Cys Met  Val Gln Val Thr Cys  Gly Thr Thr 
    3275                 3280                 3285             


Thr Leu  Asn Gly Leu Trp Leu  Asp Asp Val Val Tyr  Cys Pro Arg 
    3290                 3295                 3300             


His Val  Ile Cys Thr Ser Glu  Asp Met Leu Asn Pro  Asn Tyr Glu 
    3305                 3310                 3315             


Asp Leu  Leu Ile Arg Lys Ser  Asn His Asn Phe Leu  Val Gln Ala 
    3320                 3325                 3330             


Gly Asn  Val Gln Leu Arg Val  Ile Gly His Ser Met  Gln Asn Cys 
    3335                 3340                 3345             


Val Leu  Lys Leu Lys Val Asp  Thr Ala Asn Pro Lys  Thr Pro Lys 
    3350                 3355                 3360             


Tyr Lys  Phe Val Arg Ile Gln  Pro Gly Gln Thr Phe  Ser Val Leu 
    3365                 3370                 3375             


Ala Cys  Tyr Asn Gly Ser Pro  Ser Gly Val Tyr Gln  Cys Ala Met 
    3380                 3385                 3390             


Arg Pro  Asn Phe Thr Ile Lys  Gly Ser Phe Leu Asn  Gly Ser Cys 
    3395                 3400                 3405             


Gly Ser  Val Gly Phe Asn Ile  Asp Tyr Asp Cys Val  Ser Phe Cys 
    3410                 3415                 3420             


Tyr Met  His His Met Glu Leu  Pro Thr Gly Val His  Ala Gly Thr 
    3425                 3430                 3435             


Asp Leu  Glu Gly Asn Phe Tyr  Gly Pro Phe Val Asp  Arg Gln Thr 
    3440                 3445                 3450             


Ala Gln  Ala Ala Gly Thr Asp  Thr Thr Ile Thr Val  Asn Val Leu 
    3455                 3460                 3465             


Ala Trp  Leu Tyr Ala Ala Val  Ile Asn Gly Asp Arg  Trp Phe Leu 
    3470                 3475                 3480             


Asn Arg  Phe Thr Thr Thr Leu  Asn Asp Phe Asn Leu  Val Ala Met 
    3485                 3490                 3495             


Lys Tyr  Asn Tyr Glu Pro Leu  Thr Gln Asp His Val  Asp Ile Leu 
    3500                 3505                 3510             


Gly Pro  Leu Ser Ala Gln Thr  Gly Ile Ala Val Leu  Asp Met Cys 
    3515                 3520                 3525             


Ala Ser  Leu Lys Glu Leu Leu  Gln Asn Gly Met Asn  Gly Arg Thr 
    3530                 3535                 3540             


Ile Leu  Gly Ser Ala Leu Leu  Glu Asp Glu Phe Thr  Pro Phe Asp 
    3545                 3550                 3555             


Val Val  Arg Gln Cys Ser Gly  Val Thr Phe Gln Ser  Ala Val Lys 
    3560                 3565                 3570             


Arg Thr  Ile Lys Gly Thr His  His Trp Leu Leu Leu  Thr Ile Leu 
    3575                 3580                 3585             


Thr Ser  Leu Leu Val Leu Val  Gln Ser Thr Gln Trp  Ser Leu Phe 
    3590                 3595                 3600             


Phe Phe  Leu Tyr Glu Asn Ala  Phe Leu Pro Phe Ala  Met Gly Ile 
    3605                 3610                 3615             


Ile Ala  Met Ser Ala Phe Ala  Met Met Phe Val Lys  His Lys His 
    3620                 3625                 3630             


Ala Phe  Leu Cys Leu Phe Leu  Leu Pro Ser Leu Ala  Thr Val Ala 
    3635                 3640                 3645             


Tyr Phe  Asn Met Val Tyr Met  Pro Ala Ser Trp Val  Met Arg Ile 
    3650                 3655                 3660             


Met Thr  Trp Leu Asp Met Val  Asp Thr Ser Leu Ser  Gly Phe Lys 
    3665                 3670                 3675             


Leu Lys  Asp Cys Val Met Tyr  Ala Ser Ala Val Val  Leu Leu Ile 
    3680                 3685                 3690             


Leu Met  Thr Ala Arg Thr Val  Tyr Asp Asp Gly Ala  Arg Arg Val 
    3695                 3700                 3705             


Trp Thr  Leu Met Asn Val Leu  Thr Leu Val Tyr Lys  Val Tyr Tyr 
    3710                 3715                 3720             


Gly Asn  Ala Leu Asp Gln Ala  Ile Ser Met Trp Ala  Leu Ile Ile 
    3725                 3730                 3735             


Ser Val  Thr Ser Asn Tyr Ser  Gly Val Val Thr Thr  Val Met Phe 
    3740                 3745                 3750             


Leu Ala  Arg Gly Ile Val Phe  Met Cys Val Glu Tyr  Cys Pro Ile 
    3755                 3760                 3765             


Phe Phe  Ile Thr Gly Asn Thr  Leu Gln Cys Ile Met  Leu Val Tyr 
    3770                 3775                 3780             


Cys Phe  Leu Gly Tyr Phe Cys  Thr Cys Tyr Phe Gly  Leu Phe Cys 
    3785                 3790                 3795             


Leu Leu  Asn Arg Tyr Phe Arg  Leu Thr Leu Gly Val  Tyr Asp Tyr 
    3800                 3805                 3810             


Leu Val  Ser Thr Gln Glu Phe  Arg Tyr Met Asn Ser  Gln Gly Leu 
    3815                 3820                 3825             


Leu Pro  Pro Lys Asn Ser Ile  Asp Ala Phe Lys Leu  Asn Ile Lys 
    3830                 3835                 3840             


Leu Leu  Gly Val Gly Gly Lys  Pro Cys Ile Lys Val  Ala Thr Val 
    3845                 3850                 3855             


Gln Ser  Lys Met Ser Asp Val  Lys Cys Thr Ser Val  Val Leu Leu 
    3860                 3865                 3870             


Ser Val  Leu Gln Gln Leu Arg  Val Glu Ser Ser Ser  Lys Leu Trp 
    3875                 3880                 3885             


Ala Gln  Cys Val Gln Leu His  Asn Asp Ile Leu Leu  Ala Lys Asp 
    3890                 3895                 3900             


Thr Thr  Glu Ala Phe Glu Lys  Met Val Ser Leu Leu  Ser Val Leu 
    3905                 3910                 3915             


Leu Ser  Met Gln Gly Ala Val  Asp Ile Asn Lys Leu  Cys Glu Glu 
    3920                 3925                 3930             


Met Leu  Asp Asn Arg Ala Thr  Leu Gln Ala Ile Ala  Ser Glu Phe 
    3935                 3940                 3945             


Ser Ser  Leu Pro Ser Tyr Ala  Ala Phe Ala Thr Ala  Gln Glu Ala 
    3950                 3955                 3960             


Tyr Glu  Gln Ala Val Ala Asn  Gly Asp Ser Glu Val  Val Leu Lys 
    3965                 3970                 3975             


Lys Leu  Lys Lys Ser Leu Asn  Val Ala Lys Ser Glu  Phe Asp Arg 
    3980                 3985                 3990             


Asp Ala  Ala Met Gln Arg Lys  Leu Glu Lys Met Ala  Asp Gln Ala 
    3995                 4000                 4005             


Met Thr  Gln Met Tyr Lys Gln  Ala Arg Ser Glu Asp  Lys Arg Ala 
    4010                 4015                 4020             


Lys Val  Thr Ser Ala Met Gln  Thr Met Leu Phe Thr  Met Leu Arg 
    4025                 4030                 4035             


Lys Leu  Asp Asn Asp Ala Leu  Asn Asn Ile Ile Asn  Asn Ala Arg 
    4040                 4045                 4050             


Asp Gly  Cys Val Pro Leu Asn  Ile Ile Pro Leu Thr  Thr Ala Ala 
    4055                 4060                 4065             


Lys Leu  Met Val Val Ile Pro  Asp Tyr Asn Thr Tyr  Lys Asn Thr 
    4070                 4075                 4080             


Cys Asp  Gly Thr Thr Phe Thr  Tyr Ala Ser Ala Leu  Trp Glu Ile 
    4085                 4090                 4095             


Gln Gln  Val Val Asp Ala Asp  Ser Lys Ile Val Gln  Leu Ser Glu 
    4100                 4105                 4110             


Ile Ser  Met Asp Asn Ser Pro  Asn Leu Ala Trp Pro  Leu Ile Val 
    4115                 4120                 4125             


Thr Ala  Leu Arg Ala Asn Ser  Ala Val Lys Leu Gln  Asn Asn Glu 
    4130                 4135                 4140             


Leu Ser  Pro Val Ala Leu Arg  Gln Met Ser Cys Ala  Ala Gly Thr 
    4145                 4150                 4155             


Thr Gln  Thr Ala Cys Thr Asp  Asp Asn Ala Leu Ala  Tyr Tyr Asn 
    4160                 4165                 4170             


Thr Thr  Lys Gly Gly Arg Phe  Val Leu Ala Leu Leu  Ser Asp Leu 
    4175                 4180                 4185             


Gln Asp  Leu Lys Trp Ala Arg  Phe Pro Lys Ser Asp  Gly Thr Gly 
    4190                 4195                 4200             


Thr Ile  Tyr Thr Glu Leu Glu  Pro Pro Cys Arg Phe  Val Thr Asp 
    4205                 4210                 4215             


Thr Pro  Lys Gly Pro Lys Val  Lys Tyr Leu Tyr Phe  Ile Lys Gly 
    4220                 4225                 4230             


Leu Asn  Asn Leu Asn Arg Gly  Met Val Leu Gly Ser  Leu Ala Ala 
    4235                 4240                 4245             


Thr Val  Arg Leu Gln Ala Gly  Asn Ala Thr Glu Val  Pro Ala Asn 
    4250                 4255                 4260             


Ser Thr  Val Leu Ser Phe Cys  Ala Phe Ala Val Asp  Ala Ala Lys 
    4265                 4270                 4275             


Ala Tyr  Lys Asp Tyr Leu Ala  Ser Gly Gly Gln Pro  Ile Thr Asn 
    4280                 4285                 4290             


Cys Val  Lys Met Leu Cys Thr  His Thr Gly Thr Gly  Gln Ala Ile 
    4295                 4300                 4305             


Thr Val  Thr Pro Glu Ala Asn  Met Asp Gln Glu Ser  Phe Gly Gly 
    4310                 4315                 4320             


Ala Ser  Cys Cys Leu Tyr Cys  Arg Cys His Ile Asp  His Pro Asn 
    4325                 4330                 4335             


Pro Lys  Gly Phe Cys Asp Leu  Lys Gly Lys Tyr Val  Gln Ile Pro 
    4340                 4345                 4350             


Thr Thr  Cys Ala Asn Asp Pro  Val Gly Phe Thr Leu  Lys Asn Thr 
    4355                 4360                 4365             


Val Cys  Thr Val Cys Gly Met  Trp Lys Gly Tyr Gly  Cys Ser Cys 
    4370                 4375                 4380             


Asp Gln  Leu Arg Glu Pro Met  Leu Gln Ser Ala Asp  Ala Gln Ser 
    4385                 4390                 4395             


Phe Leu  Asn Arg Val Cys Gly  Val Ser Ala Ala Arg  Leu Thr Pro 
    4400                 4405                 4410             


Cys Gly  Thr Gly Thr Ser Thr  Asp Val Val Tyr Arg  Ala Phe Asp 
    4415                 4420                 4425             


Ile Tyr  Asn Asp Lys Val Ala  Gly Phe Ala Lys Phe  Leu Lys Thr 
    4430                 4435                 4440             


Asn Cys  Cys Arg Phe Gln Glu  Lys Asp Glu Asp Asp  Asn Leu Ile 
    4445                 4450                 4455             


Asp Ser  Tyr Phe Val Val Lys  Arg His Thr Phe Ser  Asn Tyr Gln 
    4460                 4465                 4470             


His Glu  Glu Thr Ile Tyr Asn  Leu Leu Lys Asp Cys  Pro Ala Val 
    4475                 4480                 4485             


Ala Lys  His Asp Phe Phe Lys  Phe Arg Ile Asp Gly  Asp Met Val 
    4490                 4495                 4500             


Pro His  Ile Ser Arg Gln Arg  Leu Thr Lys Tyr Thr  Met Ala Asp 
    4505                 4510                 4515             


Leu Val  Tyr Ala Leu Arg His  Phe Asp Glu Gly Asn  Cys Asp Thr 
    4520                 4525                 4530             


Leu Lys  Glu Ile Leu Val Thr  Tyr Asn Cys Cys Asp  Asp Asp Tyr 
    4535                 4540                 4545             


Phe Asn  Lys Lys Asp Trp Tyr  Asp Phe Val Glu Asn  Pro Asp Ile 
    4550                 4555                 4560             


Leu Arg  Val Tyr Ala Asn Leu  Gly Glu Arg Val Arg  Gln Ala Leu 
    4565                 4570                 4575             


Leu Lys  Thr Val Gln Phe Cys  Asp Ala Met Arg Asn  Ala Gly Ile 
    4580                 4585                 4590             


Val Gly  Val Leu Thr Leu Asp  Asn Gln Asp Leu Asn  Gly Asn Trp 
    4595                 4600                 4605             


Tyr Asp  Phe Gly Asp Phe Ile  Gln Thr Thr Pro Gly  Ser Gly Val 
    4610                 4615                 4620             


Pro Val  Val Asp Ser Tyr Tyr  Ser Leu Leu Met Pro  Ile Leu Thr 
    4625                 4630                 4635             


Leu Thr  Arg Ala Leu Thr Ala  Glu Ser His Val Asp  Thr Asp Leu 
    4640                 4645                 4650             


Thr Lys  Pro Tyr Ile Lys Trp  Asp Leu Leu Lys Tyr  Asp Phe Thr 
    4655                 4660                 4665             


Glu Glu  Arg Leu Lys Leu Phe  Asp Arg Tyr Phe Lys  Tyr Trp Asp 
    4670                 4675                 4680             


Gln Thr  Tyr His Pro Asn Cys  Val Asn Cys Leu Asp  Asp Arg Cys 
    4685                 4690                 4695             


Ile Leu  His Cys Ala Asn Phe  Asn Val Leu Phe Ser  Thr Val Phe 
    4700                 4705                 4710             


Pro Pro  Thr Ser Phe Gly Pro  Leu Val Arg Lys Ile  Phe Val Asp 
    4715                 4720                 4725             


Gly Val  Pro Phe Val Val Ser  Thr Gly Tyr His Phe  Arg Glu Leu 
    4730                 4735                 4740             


Gly Val  Val His Asn Gln Asp  Val Asn Leu His Ser  Ser Arg Leu 
    4745                 4750                 4755             


Ser Phe  Lys Glu Leu Leu Val  Tyr Ala Ala Asp Pro  Ala Met His 
    4760                 4765                 4770             


Ala Ala  Ser Gly Asn Leu Leu  Leu Asp Lys Arg Thr  Thr Cys Phe 
    4775                 4780                 4785             


Ser Val  Ala Ala Leu Thr Asn  Asn Val Ala Phe Gln  Thr Val Lys 
    4790                 4795                 4800             


Pro Gly  Asn Phe Asn Lys Asp  Phe Tyr Asp Phe Ala  Val Ser Lys 
    4805                 4810                 4815             


Gly Phe  Phe Lys Glu Gly Ser  Ser Val Glu Leu Lys  His Phe Phe 
    4820                 4825                 4830             


Phe Ala  Gln Asp Gly Asn Ala  Ala Ile Ser Asp Tyr  Asp Tyr Tyr 
    4835                 4840                 4845             


Arg Tyr  Asn Leu Pro Thr Met  Cys Asp Ile Arg Gln  Leu Leu Phe 
    4850                 4855                 4860             


Val Val  Glu Val Val Asp Lys  Tyr Phe Asp Cys Tyr  Asp Gly Gly 
    4865                 4870                 4875             


Cys Ile  Asn Ala Asn Gln Val  Ile Val Asn Asn Leu  Asp Lys Ser 
    4880                 4885                 4890             


Ala Gly  Phe Pro Phe Asn Lys  Trp Gly Lys Ala Arg  Leu Tyr Tyr 
    4895                 4900                 4905             


Asp Ser  Met Ser Tyr Glu Asp  Gln Asp Ala Leu Phe  Ala Tyr Thr 
    4910                 4915                 4920             


Lys Arg  Asn Val Ile Pro Thr  Ile Thr Gln Met Asn  Leu Lys Tyr 
    4925                 4930                 4935             


Ala Ile  Ser Ala Lys Asn Arg  Ala Arg Thr Val Ala  Gly Val Ser 
    4940                 4945                 4950             


Ile Cys  Ser Thr Met Thr Asn  Arg Gln Phe His Gln  Lys Leu Leu 
    4955                 4960                 4965             


Lys Ser  Ile Ala Ala Thr Arg  Gly Ala Thr Val Val  Ile Gly Thr 
    4970                 4975                 4980             


Ser Lys  Phe Tyr Gly Gly Trp  His Asn Met Leu Lys  Thr Val Tyr 
    4985                 4990                 4995             


Ser Asp  Val Glu Asn Pro His  Leu Met Gly Trp Asp  Tyr Pro Lys 
    5000                 5005                 5010             


Cys Asp  Arg Ala Met Pro Asn  Met Leu Arg Ile Met  Ala Ser Leu 
    5015                 5020                 5025             


Val Leu  Ala Arg Lys His Thr  Thr Cys Cys Ser Leu  Ser His Arg 
    5030                 5035                 5040             


Phe Tyr  Arg Leu Ala Asn Glu  Cys Ala Gln Val Leu  Ser Glu Met 
    5045                 5050                 5055             


Val Met  Cys Gly Gly Ser Leu  Tyr Val Lys Pro Gly  Gly Thr Ser 
    5060                 5065                 5070             


Ser Gly  Asp Ala Thr Thr Ala  Tyr Ala Asn Ser Val  Phe Asn Ile 
    5075                 5080                 5085             


Cys Gln  Ala Val Thr Ala Asn  Val Asn Ala Leu Leu  Ser Thr Asp 
    5090                 5095                 5100             


Gly Asn  Lys Ile Ala Asp Lys  Tyr Val Arg Asn Leu  Gln His Arg 
    5105                 5110                 5115             


Leu Tyr  Glu Cys Leu Tyr Arg  Asn Arg Asp Val Asp  Thr Asp Phe 
    5120                 5125                 5130             


Val Asn  Glu Phe Tyr Ala Tyr  Leu Arg Lys His Phe  Ser Met Met 
    5135                 5140                 5145             


Ile Leu  Ser Asp Asp Ala Val  Val Cys Phe Asn Ser  Thr Tyr Ala 
    5150                 5155                 5160             


Ser Gln  Gly Leu Val Ala Ser  Ile Lys Asn Phe Lys  Ser Val Leu 
    5165                 5170                 5175             


Tyr Tyr  Gln Asn Asn Val Phe  Met Ser Glu Ala Lys  Cys Trp Thr 
    5180                 5185                 5190             


Glu Thr  Asp Leu Thr Lys Gly  Pro His Glu Phe Cys  Ser Gln His 
    5195                 5200                 5205             


Thr Met  Leu Val Lys Gln Gly  Asp Asp Tyr Val Tyr  Leu Pro Tyr 
    5210                 5215                 5220             


Pro Asp  Pro Ser Arg Ile Leu  Gly Ala Gly Cys Phe  Val Asp Asp 
    5225                 5230                 5235             


Ile Val  Lys Thr Asp Gly Thr  Leu Met Ile Glu Arg  Phe Val Ser 
    5240                 5245                 5250             


Leu Ala  Ile Asp Ala Tyr Pro  Leu Thr Lys His Pro  Asn Gln Glu 
    5255                 5260                 5265             


Tyr Ala  Asp Val Phe His Leu  Tyr Leu Gln Tyr Ile  Arg Lys Leu 
    5270                 5275                 5280             


His Asp  Glu Leu Thr Gly His  Met Leu Asp Met Tyr  Ser Val Met 
    5285                 5290                 5295             


Leu Thr  Asn Asp Asn Thr Ser  Arg Tyr Trp Glu Pro  Glu Phe Tyr 
    5300                 5305                 5310             


Glu Ala  Met Tyr Thr Pro His  Thr Val Leu Gln Ala  Val Gly Ala 
    5315                 5320                 5325             


Cys Val  Leu Cys Asn Ser Gln  Thr Ser Leu Arg Cys  Gly Ala Cys 
    5330                 5335                 5340             


Ile Arg  Arg Pro Phe Leu Cys  Cys Lys Cys Cys Tyr  Asp His Val 
    5345                 5350                 5355             


Ile Ser  Thr Ser His Lys Leu  Val Leu Ser Val Asn  Pro Tyr Val 
    5360                 5365                 5370             


Cys Asn  Ala Pro Gly Cys Asp  Val Thr Asp Val Thr  Gln Leu Tyr 
    5375                 5380                 5385             


Leu Gly  Gly Met Ser Tyr Tyr  Cys Lys Ser His Lys  Pro Pro Ile 
    5390                 5395                 5400             


Ser Phe  Pro Leu Cys Ala Asn  Gly Gln Val Phe Gly  Leu Tyr Lys 
    5405                 5410                 5415             


Asn Thr  Cys Val Gly Ser Asp  Asn Val Thr Asp Phe  Asn Ala Ile 
    5420                 5425                 5430             


Ala Thr  Cys Asp Trp Thr Asn  Ala Gly Asp Tyr Ile  Leu Ala Asn 
    5435                 5440                 5445             


Thr Cys  Thr Glu Arg Leu Lys  Leu Phe Ala Ala Glu  Thr Leu Lys 
    5450                 5455                 5460             


Ala Thr  Glu Glu Thr Phe Lys  Leu Ser Tyr Gly Ile  Ala Thr Val 
    5465                 5470                 5475             


Arg Glu  Val Leu Ser Asp Arg  Glu Leu His Leu Ser  Trp Glu Val 
    5480                 5485                 5490             


Gly Lys  Pro Arg Pro Pro Leu  Asn Arg Asn Tyr Val  Phe Thr Gly 
    5495                 5500                 5505             


Tyr Arg  Val Thr Lys Asn Ser  Lys Val Gln Ile Gly  Glu Tyr Thr 
    5510                 5515                 5520             


Phe Glu  Lys Gly Asp Tyr Gly  Asp Ala Val Val Tyr  Arg Gly Thr 
    5525                 5530                 5535             


Thr Thr  Tyr Lys Leu Asn Val  Gly Asp Tyr Phe Val  Leu Thr Ser 
    5540                 5545                 5550             


His Thr  Val Met Pro Leu Ser  Ala Pro Thr Leu Val  Pro Gln Glu 
    5555                 5560                 5565             


His Tyr  Val Arg Ile Thr Gly  Leu Tyr Pro Thr Leu  Asn Ile Ser 
    5570                 5575                 5580             


Asp Glu  Phe Ser Ser Asn Val  Ala Asn Tyr Gln Lys  Val Gly Met 
    5585                 5590                 5595             


Gln Lys  Tyr Ser Thr Leu Gln  Gly Pro Pro Gly Thr  Gly Lys Ser 
    5600                 5605                 5610             


His Phe  Ala Ile Gly Leu Ala  Leu Tyr Tyr Pro Ser  Ala Arg Ile 
    5615                 5620                 5625             


Val Tyr  Thr Ala Cys Ser His  Ala Ala Val Asp Ala  Leu Cys Glu 
    5630                 5635                 5640             


Lys Ala  Leu Lys Tyr Leu Pro  Ile Asp Lys Cys Ser  Arg Ile Ile 
    5645                 5650                 5655             


Pro Ala  Arg Ala Arg Val Glu  Cys Phe Asp Lys Phe  Lys Val Asn 
    5660                 5665                 5670             


Ser Thr  Leu Glu Gln Tyr Val  Phe Cys Thr Val Asn  Ala Leu Pro 
    5675                 5680                 5685             


Glu Thr  Thr Ala Asp Ile Val  Val Phe Asp Glu Ile  Ser Met Ala 
    5690                 5695                 5700             


Thr Asn  Tyr Asp Leu Ser Val  Val Asn Ala Arg Leu  Arg Ala Lys 
    5705                 5710                 5715             


His Tyr  Val Tyr Ile Gly Asp  Pro Ala Gln Leu Pro  Ala Pro Arg 
    5720                 5725                 5730             


Thr Leu  Leu Thr Lys Gly Thr  Leu Glu Pro Glu Tyr  Phe Asn Ser 
    5735                 5740                 5745             


Val Cys  Arg Leu Met Lys Thr  Ile Gly Pro Asp Met  Phe Leu Gly 
    5750                 5755                 5760             


Thr Cys  Arg Arg Cys Pro Ala  Glu Ile Val Asp Thr  Val Ser Ala 
    5765                 5770                 5775             


Leu Val  Tyr Asp Asn Lys Leu  Lys Ala His Lys Asp  Lys Ser Ala 
    5780                 5785                 5790             


Gln Cys  Phe Lys Met Phe Tyr  Lys Gly Val Ile Thr  His Asp Val 
    5795                 5800                 5805             


Ser Ser  Ala Ile Asn Arg Pro  Gln Ile Gly Val Val  Arg Glu Phe 
    5810                 5815                 5820             


Leu Thr  Arg Asn Pro Ala Trp  Arg Lys Ala Val Phe  Ile Ser Pro 
    5825                 5830                 5835             


Tyr Asn  Ser Gln Asn Ala Val  Ala Ser Lys Ile Leu  Gly Leu Pro 
    5840                 5845                 5850             


Thr Gln  Thr Val Asp Ser Ser  Gln Gly Ser Glu Tyr  Asp Tyr Val 
    5855                 5860                 5865             


Ile Phe  Thr Gln Thr Thr Glu  Thr Ala His Ser Cys  Asn Val Asn 
    5870                 5875                 5880             


Arg Phe  Asn Val Ala Ile Thr  Arg Ala Lys Val Gly  Ile Leu Cys 
    5885                 5890                 5895             


Ile Met  Ser Asp Arg Asp Leu  Tyr Asp Lys Leu Gln  Phe Thr Ser 
    5900                 5905                 5910             


Leu Glu  Ile Pro Arg Arg Asn  Val Ala Thr Leu Gln  Ala Glu Asn 
    5915                 5920                 5925             


Val Thr  Gly Leu Phe Lys Asp  Cys Ser Lys Val Ile  Thr Gly Leu 
    5930                 5935                 5940             


His Pro  Thr Gln Ala Pro Thr  His Leu Ser Val Asp  Thr Lys Phe 
    5945                 5950                 5955             


Lys Thr  Glu Gly Leu Cys Val  Asp Ile Pro Gly Ile  Pro Lys Asp 
    5960                 5965                 5970             


Met Thr  Tyr Arg Arg Leu Ile  Ser Met Met Gly Phe  Lys Met Asn 
    5975                 5980                 5985             


Tyr Gln  Val Asn Gly Tyr Pro  Asn Met Phe Ile Thr  Arg Glu Glu 
    5990                 5995                 6000             


Ala Ile  Arg His Val Arg Ala  Trp Ile Gly Phe Asp  Val Glu Gly 
    6005                 6010                 6015             


Cys His  Ala Thr Arg Glu Ala  Val Gly Thr Asn Leu  Pro Leu Gln 
    6020                 6025                 6030             


Leu Gly  Phe Ser Thr Gly Val  Asn Leu Val Ala Val  Pro Thr Gly 
    6035                 6040                 6045             


Tyr Val  Asp Thr Pro Asn Asn  Thr Asp Phe Ser Arg  Val Ser Ala 
    6050                 6055                 6060             


Lys Pro  Pro Pro Gly Asp Gln  Phe Lys His Leu Ile  Pro Leu Met 
    6065                 6070                 6075             


Tyr Lys  Gly Leu Pro Trp Asn  Val Val Arg Ile Lys  Ile Val Gln 
    6080                 6085                 6090             


Met Leu  Ser Asp Thr Leu Lys  Asn Leu Ser Asp Arg  Val Val Phe 
    6095                 6100                 6105             


Val Leu  Trp Ala His Gly Phe  Glu Leu Thr Ser Met  Lys Tyr Phe 
    6110                 6115                 6120             


Val Lys  Ile Gly Pro Glu Arg  Thr Cys Cys Leu Cys  Asp Arg Arg 
    6125                 6130                 6135             


Ala Thr  Cys Phe Ser Thr Ala  Ser Asp Thr Tyr Ala  Cys Trp His 
    6140                 6145                 6150             


His Ser  Ile Gly Phe Asp Tyr  Val Tyr Asn Pro Phe  Met Ile Asp 
    6155                 6160                 6165             


Val Gln  Gln Trp Gly Phe Thr  Gly Asn Leu Gln Ser  Asn His Asp 
    6170                 6175                 6180             


Leu Tyr  Cys Gln Val His Gly  Asn Ala His Val Ala  Ser Cys Asp 
    6185                 6190                 6195             


Ala Ile  Met Thr Arg Cys Leu  Ala Val His Glu Cys  Phe Val Lys 
    6200                 6205                 6210             


Arg Val  Asp Trp Thr Ile Glu  Tyr Pro Ile Ile Gly  Asp Glu Leu 
    6215                 6220                 6225             


Lys Ile  Asn Ala Ala Cys Arg  Lys Val Gln His Met  Val Val Lys 
    6230                 6235                 6240             


Ala Ala  Leu Leu Ala Asp Lys  Phe Pro Val Leu His  Asp Ile Gly 
    6245                 6250                 6255             


Asn Pro  Lys Ala Ile Lys Cys  Val Pro Gln Ala Asp  Val Glu Trp 
    6260                 6265                 6270             


Lys Phe  Tyr Asp Ala Gln Pro  Cys Ser Asp Lys Ala  Tyr Lys Ile 
    6275                 6280                 6285             


Glu Glu  Leu Phe Tyr Ser Tyr  Ala Thr His Ser Asp  Lys Phe Thr 
    6290                 6295                 6300             


Asp Gly  Val Cys Leu Phe Trp  Asn Cys Asn Val Asp  Arg Tyr Pro 
    6305                 6310                 6315             


Ala Asn  Ser Ile Val Cys Arg  Phe Asp Thr Arg Val  Leu Ser Asn 
    6320                 6325                 6330             


Leu Asn  Leu Pro Gly Cys Asp  Gly Gly Ser Leu Tyr  Val Asn Lys 
    6335                 6340                 6345             


His Ala  Phe His Thr Pro Ala  Phe Asp Lys Ser Ala  Phe Val Asn 
    6350                 6355                 6360             


Leu Lys  Gln Leu Pro Phe Phe  Tyr Tyr Ser Asp Ser  Pro Cys Glu 
    6365                 6370                 6375             


Ser His  Gly Lys Gln Val Val  Ser Asp Ile Asp Tyr  Val Pro Leu 
    6380                 6385                 6390             


Lys Ser  Ala Thr Cys Ile Thr  Arg Cys Asn Leu Gly  Gly Ala Val 
    6395                 6400                 6405             


Cys Arg  His His Ala Asn Glu  Tyr Arg Leu Tyr Leu  Asp Ala Tyr 
    6410                 6415                 6420             


Asn Met  Met Ile Ser Ala Gly  Phe Ser Leu Trp Val  Tyr Lys Gln 
    6425                 6430                 6435             


Phe Asp  Thr Tyr Asn Leu Trp  Asn Thr Phe Thr Arg  Leu Gln Ser 
    6440                 6445                 6450             


Leu Glu  Asn Val Ala Phe Asn  Val Val Asn Lys Gly  His Phe Asp 
    6455                 6460                 6465             


Gly Gln  Gln Gly Glu Val Pro  Val Ser Ile Ile Asn  Asn Thr Val 
    6470                 6475                 6480             


Tyr Thr  Lys Val Asp Gly Val  Asp Val Glu Leu Phe  Glu Asn Lys 
    6485                 6490                 6495             


Thr Thr  Leu Pro Val Asn Val  Ala Phe Glu Leu Trp  Ala Lys Arg 
    6500                 6505                 6510             


Asn Ile  Lys Pro Val Pro Glu  Val Lys Ile Leu Asn  Asn Leu Gly 
    6515                 6520                 6525             


Val Asp  Ile Ala Ala Asn Thr  Val Ile Trp Asp Tyr  Lys Arg Asp 
    6530                 6535                 6540             


Ala Pro  Ala His Ile Ser Thr  Ile Gly Val Cys Ser  Met Thr Asp 
    6545                 6550                 6555             


Ile Ala  Lys Lys Pro Thr Glu  Thr Ile Cys Ala Pro  Leu Thr Val 
    6560                 6565                 6570             


Phe Phe  Asp Gly Arg Val Asp  Gly Gln Val Asp Leu  Phe Arg Asn 
    6575                 6580                 6585             


Ala Arg  Asn Gly Val Leu Ile  Thr Glu Gly Ser Val  Lys Gly Leu 
    6590                 6595                 6600             


Gln Pro  Ser Val Gly Pro Lys  Gln Ala Ser Leu Asn  Gly Val Thr 
    6605                 6610                 6615             


Leu Ile  Gly Glu Ala Val Lys  Thr Gln Phe Asn Tyr  Tyr Lys Lys 
    6620                 6625                 6630             


Val Asp  Gly Val Val Gln Gln  Leu Pro Glu Thr Tyr  Phe Thr Gln 
    6635                 6640                 6645             


Ser Arg  Asn Leu Gln Glu Phe  Lys Pro Arg Ser Gln  Met Glu Ile 
    6650                 6655                 6660             


Asp Phe  Leu Glu Leu Ala Met  Asp Glu Phe Ile Glu  Arg Tyr Lys 
    6665                 6670                 6675             


Leu Glu  Gly Tyr Ala Phe Glu  His Ile Val Tyr Gly  Asp Phe Ser 
    6680                 6685                 6690             


His Ser  Gln Leu Gly Gly Leu  His Leu Leu Ile Gly  Leu Ala Lys 
    6695                 6700                 6705             


Arg Phe  Lys Glu Ser Pro Phe  Glu Leu Glu Asp Phe  Ile Pro Met 
    6710                 6715                 6720             


Asp Ser  Thr Val Lys Asn Tyr  Phe Ile Thr Asp Ala  Gln Thr Gly 
    6725                 6730                 6735             


Ser Ser  Lys Cys Val Cys Ser  Val Ile Asp Leu Leu  Leu Asp Asp 
    6740                 6745                 6750             


Phe Val  Glu Ile Ile Lys Ser  Gln Asp Leu Ser Val  Val Ser Lys 
    6755                 6760                 6765             


Val Val  Lys Val Thr Ile Asp  Tyr Thr Glu Ile Ser  Phe Met Leu 
    6770                 6775                 6780             


Trp Cys  Lys Asp Gly His Val  Glu Thr Phe Tyr Pro  Lys Leu Gln 
    6785                 6790                 6795             


Ser Ser  Gln Ala Trp Gln Pro  Gly Val Ala Met Pro  Asn Leu Tyr 
    6800                 6805                 6810             


Lys Met  Gln Arg Met Leu Leu  Glu Lys Cys Asp Leu  Gln Asn Tyr 
    6815                 6820                 6825             


Gly Asp  Ser Ala Thr Leu Pro  Lys Gly Ile Met Met  Asn Val Ala 
    6830                 6835                 6840             


Lys Tyr  Thr Gln Leu Cys Gln  Tyr Leu Asn Thr Leu  Thr Leu Ala 
    6845                 6850                 6855             


Val Pro  Tyr Asn Met Arg Val  Ile His Phe Gly Ala  Gly Ser Asp 
    6860                 6865                 6870             


Lys Gly  Val Ala Pro Gly Thr  Ala Val Leu Arg Gln  Trp Leu Pro 
    6875                 6880                 6885             


Thr Gly  Thr Leu Leu Val Asp  Ser Asp Leu Asn Asp  Phe Val Ser 
    6890                 6895                 6900             


Asp Ala  Asp Ser Thr Leu Ile  Gly Asp Cys Ala Thr  Val His Thr 
    6905                 6910                 6915             


Ala Asn  Lys Trp Asp Leu Ile  Ile Ser Asp Met Tyr  Asp Pro Lys 
    6920                 6925                 6930             


Thr Lys  Asn Val Thr Lys Glu  Asn Asp Ser Lys Glu  Gly Phe Phe 
    6935                 6940                 6945             


Thr Tyr  Ile Cys Gly Phe Ile  Gln Gln Lys Leu Ala  Leu Gly Gly 
    6950                 6955                 6960             


Ser Val  Ala Ile Lys Ile Thr  Glu His Ser Trp Asn  Ala Asp Leu 
    6965                 6970                 6975             


Tyr Lys  Leu Met Gly His Phe  Ala Trp Trp Thr Ala  Phe Val Thr 
    6980                 6985                 6990             


Asn Val  Asn Ala Ser Ser Ser  Glu Ala Phe Leu Ile  Gly Cys Asn 
    6995                 7000                 7005             


Tyr Leu  Gly Lys Pro Arg Glu  Gln Ile Asp Gly Tyr  Val Met His 
    7010                 7015                 7020             


Ala Asn  Tyr Ile Phe Trp Arg  Asn Thr Asn Pro Ile  Gln Leu Ser 
    7025                 7030                 7035             


Ser Tyr  Ser Leu Phe Asp Met  Ser Lys Phe Pro Leu  Lys Leu Arg 
    7040                 7045                 7050             


Gly Thr  Ala Val Met Ser Leu  Lys Glu Gly Gln Ile  Asn Asp Met 
    7055                 7060                 7065             


Ile Leu  Ser Leu Leu Ser Lys  Gly Arg Leu Ile Ile  Arg Glu Asn 
    7070                 7075                 7080             


Asn Arg  Val Val Ile Ser Ser  Asp Val Leu Val Asn  Asn 
    7085                 7090                 7095     


<210>  3
<211>  1273
<212>  PRT
<213>  SARS-CoV-2 beta

<400>  3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  4
<211>  220
<212>  PRT
<213>  SARS-CoV-2 beta

<400>  4

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
        195                 200                 205             


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
    210                 215                 220 


<210>  5
<211>  72
<212>  PRT
<213>  SARS-CoV-2 beta

<400>  5

Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
            20                  25                  30          


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
        35                  40                  45              


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
    50                  55                  60                  


Asn Gly Val Gly Tyr Gln Pro Tyr 
65                  70          


<210>  6
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 CH1-CH3 LS G1m17 IgHG1*01 

<400>  6

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  7
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 CH1-CH3 LS, ALE G1m17 IgHG1*01 

<400>  7

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  8
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 CL IgLC*01 

<400>  8

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  9
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 CL (CK) k1m3 IgKC*01 

<400>  9

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  10
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  10

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  11
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  11

Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
1               5                   10  


<210>  12
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  12

Gly Lys Pro Gly Ser Gly Glu Gly 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  13

Ser Gly Lys Pro Gly Ser Gly Glu 
1               5               


<210>  14
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Asx Pro Xaa Xaa Xaa Glx 
1               5       


<210>  15
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Gly Xaa Ser Tyr 
1               


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  16

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  17
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  18
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  18

Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser 
        


<210>  19
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  19

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  20
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker 

<400>  20

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Linker

<400>  21

Gly Gly Gly Gly Ser 
1               5   


<210>  22
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 VH

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Leu Ser Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Pro Leu Val Gly Phe Gly Asp Asn Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 CDRH1 

<400>  23

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 CDRH2 

<400>  24

Ile Leu Ser Asp Gly Ser Asn Lys 
1               5               


<210>  25
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 CDRH3 

<400>  25

Ala Arg Asp Arg Ser Pro Leu Val Gly Phe Gly Asp Asn Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  26
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 VL 

<400>  26

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Thr Asp Ser Ser Gly Asn Gln 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  27
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 CDRL1 

<400>  27

Ala Leu Pro Lys Lys Tyr 
1               5       


<210>  28
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 CDRL2 

<400>  28

Glu Asp Ser 
1           


<210>  29
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 CDRL3 

<400>  29

Ser Ser Thr Asp Ser Ser Gly Asn Gln Gly Val 
1               5                   10      


<210>  30
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 VH 

<400>  30
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctagagtg ggtggcagtt atattatctg atggaagtaa taaatattac      180

gcagactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatcga      300

agtcccctcg tgggattcgg ggacaactat ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  31
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_1 VL

<400>  31
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacaaac ggccaggatc       60

acctgctctg gagatgcatt gccaaaaaaa tatgcttatt ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctatgaggac agcaaacgac cctccgggat ccctgagaga      180

ttctctggct ccagctcagg gacaatggcc accttgacta tcagtggggc ccaggtggag      240

gatgaagctg actactactg ttcctcaaca gacagcagtg gtaatcaagg ggtattcggc      300

ggagggacca agctgaccgt cctag                                            325


<210>  32
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 VH 

<400>  32

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Leu Ser Gly Phe Ser Val Asn Thr Gly 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Leu Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Val Leu Val Trp Phe Gly Glu Val Leu Pro Asp Ala Phe 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 CDRH1 

<400>  33

Gly Phe Ser Val Asn Thr Gly Gly Val Gly 
1               5                   10  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2  CDRH2 

<400>  34

Ile Tyr Trp Asn Asp Asp Lys 
1               5           


<210>  35
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 CDRH3 

<400>  35

Ala His Val Leu Val Trp Phe Gly Glu Val Leu Pro Asp Ala Phe Asp 
1               5                   10                  15      


Val 
    

<210>  36
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 VL 

<400>  36

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Glu Thr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Ile Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Glu Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Thr Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Lys Thr Ile Ala Gly 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 CDRL1

<400>  37

Lys Leu Gly Glu Thr Tyr 
1               5       


<210>  38
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 CDRL2

<400>  38

Gln Asp Asn 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 CDRL2 

<400>  39

Gln Ala Trp Asp Lys Thr Ile Ala Gly 
1               5                   


<210>  40
<211>  376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 VH 

<400>  40
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcaaat tatctgggtt ttcagtcaac actggtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattt attggaatga tgataagttg      180

tacagcccat ctctgaagag caggctcacc gtcaccaagg acacatccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacacgta      300

ttagtttggt tcggggaggt attacccgat gcttttgatg tgtggggcca agggacaatg      360

gtcaccgtct cttcag                                                      376


<210>  41
<211>  319
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_2 VL 

<400>  41
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt gggggagaca tatgctagtt ggtatcagca gaagccaggc      120

cagtccccta ttctagtcat ctatcaagat aacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctga gaacacagcc actctgacca tcagcgggac ccagactatg      240

gatgaggctg actattactg tcaggcgtgg gacaagacca tcgccggatt cggcggaggg      300

accaagctga ccgtcctag                                                   319


<210>  42
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 VH 

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ile Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Arg Tyr His Tyr Ala Ser Ser Gly Tyr Tyr Gln Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 CDRH1


<400>  43

Gly Phe Ile Phe Ser Thr Tyr Gly 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 CDRH2 

<400>  44

Ile Trp Tyr Asp Gly Thr Lys Lys 
1               5               


<210>  45
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 CDRH3 

<400>  45

Ala Ser Asn Arg Tyr His Tyr Ala Ser Ser Gly Tyr Tyr Gln Leu Asp 
1               5                   10                  15      


Tyr 
    

<210>  46
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 VL 

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Tyr Asp His Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 CDRL1

<400>  47

Gln Asp Ile Ser Asn Ser 
1               5       


<210>  48
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 CDRL2 

<400>  48

Asp Ala Ser 
1           


<210>  49
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 CDRL3 

<400>  49

Gln His Tyr Asp His Leu Pro Leu Thr 
1               5                   


<210>  50
<211>  373
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 VH 

<400>  50
gaggtgcagc tggtggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt catcttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggctatt atatggtatg atggaactaa aaaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctacaaatga acatcctgag agccgaggac acggctgtgt attactgtgc gagtaaccgg      300

tatcactatg ctagtagtgg ttattatcaa cttgactact ggggccaggg aaccctggtc      360

accgtctcct cag                                                         373


<210>  51
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_3 VL 

<400>  51
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactctttaa attggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatgttg caacatatta ctgtcaacat tatgatcatc tccctctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210>  52
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 VH

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Phe Pro Asp Ser Ser Ser Trp Ser Gly Phe Thr Ile Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 CDRH1 

<400>  53

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 CDRH2 

<400>  54

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  55
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 CDRH3 

<400>  55

Ala Arg Ala Phe Pro Asp Ser Ser Ser Trp Ser Gly Phe Thr Ile Asp 
1               5                   10                  15      


Tyr 
    

<210>  56
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 VL 

<400>  56

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Glu Arg Lys Ser Val 
            20                  25                  30          


His Trp Cys Gln Gln Lys Pro Gly Gln Ala Pro Ala Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Ser Asp Gln 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  57
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 CDRL1 

<400>  57

Asn Ile Glu Arg Lys Ser 
1               5       


<210>  58
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 CDRL2 

<400>  58

Asp Asp Ser 
1           


<210>  59
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 CDRL3 

<400>  59

Gln Val Trp Asp Ser Gly Ser Asp Gln Val Ile 
1               5                   10      


<210>  60
<211>  373
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 VH

<400>  60
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aattatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcagtt atatggtatg atggaagtaa taaattctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cagtctctat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt atttctgtgc gagggccttt      300

cccgatagca gcagctggtc cggcttcact attgactact ggggccaggg aaccctggtc      360

accgtctcct cag                                                         373


<210>  61
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_4 VL 

<400>  61
tcctatgagc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tgagaggaaa agtgtgcact ggtgccagca gaagccaggc      120

caggcccctg cgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtggta gtgatcaggt gatattcggc      300

ggagggacca agctgaccgt cctag                                            325


<210>  62
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 VH 

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Val Ile Trp Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Ala Gly Glu Trp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 CDRH1 

<400>  63

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 CDRH2 

<400>  64

Ile Trp Tyr Asp Gly Ser Asn Arg 
1               5               


<210>  65
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 CDRH3 

<400>  65

Ala Arg Ala Val Ala Gly Glu Trp Tyr Phe Asp Tyr 
1               5                   10          


<210>  66
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 VL 

<400>  66

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Ala Lys His Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ile Gly Ser Ser 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  67
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 CDRL1 

<400>  67

Ala Leu Ala Lys His Tyr 
1               5       


<210>  68
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 CDRL2 

<400>  68

Lys Asp Ser 
1           


<210>  69
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 CDRL3

<400>  69

Gln Ser Ala Asp Ser Ile Gly Ser Ser Trp Val 
1               5                   10      


<210>  70
<211>  358
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 VH

<400>  70
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacagtt atttggtatg atggaagtaa tcgatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatgg acagcctgag agccgaggac acggctgttt attactgtgc gagagcagtg      300

gccggggaat ggtactttga ctactggggc cagggaaccc tggtcaccgt ctcctcag        358


<210>  71
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_5 VL 

<400>  71
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctccg gagatgcatt ggcaaaacac tatgcttatt ggtaccggca gaagccaggc      120

caggcccctg tgctggtgat atataaagac agtgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcattg gtagttcttg ggtgttcggc      300

ggagggacca agctgaccgt cctag                                            325


<210>  72
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 VH 

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Asn Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Val Ala Pro Val Ala Gly Thr Ala His Gln Thr Thr 
            100                 105                 110         


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  73
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 CDRH1 

<400>  73

Gly Gly Ser Val Asn Ser Gly Ser Tyr Tyr 
1               5                   10  


<210>  74
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 CDRH2

<400>  74

Ile Phe Tyr Ser Gly Ser Thr 
1               5           


<210>  75
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 CDRH3

<400>  75

Ala Arg Glu Val Ala Pro Val Ala Gly Thr Ala His Gln Thr Thr Tyr 
1               5                   10                  15      


Tyr Phe Asp Tyr 
            20  


<210>  76
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 VL

<400>  76

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Pro Leu Glu Glu 
                85                  90                  95      


Gly Lys Arg Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  77
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 CDRL1 

<400>  77

Gln Ser Ile Ser Thr Tyr 
1               5       


<210>  78
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 CDRL2

<400>  78

Ala Ala Ser 
1           


<210>  79
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 CDRL3

<400>  79

Gln Gln Ser Arg Pro Leu Glu Glu Gly Lys Arg Tyr Thr 
1               5                   10              


<210>  80
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 VH

<400>  80
caggtgcagc tacaggagtc gggcccagga ttggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccgtcaac agtggcagtt actactggag ctggatccgg      120

cagcccccag ggaagggact ggagtggatt gggtatatct tttacagtgg gagcacctac      180

tacaacccct ccctcaagag tcgagtcacc atatcaatag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgctgcg gacacagccg tgtattactg tgcgagagag      300

gttgcgccag tggctggtac tgcccaccaa acaacgtact actttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  81
<211>  334
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_6 VL

<400>  81
gacatcgtga tgacccagtc tccatcctcc ctgtctgtgt ctgtaggaga cagagtcagc       60

atcacttgcc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcacagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agtcggccgc tcgaagaagg caaaaggtac      300

acttttggcc aggggaccaa gctggagatc aaac                                  334


<210>  82
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 VH

<400>  82

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Asn Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe His Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Ser Gly Ser Ser Thr Trp Leu Gly Pro Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 CDRH1 

<400>  83

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 CDRH2

<400>  84

Ile Ile Pro Ile Phe His Thr Ala 
1               5               


<210>  85
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 CDRH3

<400>  85

Ala Gly Asp Ser Gly Ser Ser Thr Trp Leu Gly Pro Phe Asp Ile 
1               5                   10                  15  


<210>  86
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 VL

<400>  86

Val Ile Trp Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Gly Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  87
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 CDRL1 

<400>  87

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  88
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 CDRL2

<400>  88

Asp Ala Ser 
1           


<210>  89
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 CDRL3

<400>  89

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  90
<211>  367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 VH

<400>  90
gaggtgcagc tggtgcagtc tggggctgag gtgaacaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcca tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttcatac agcaaactac      180

gcacagaagt tccacggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga acagcctgag atctgaggac acggccgtgt attactgtgc gggggatagt      300

gggagctcaa cctggctcgg accttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcag                                                                367


<210>  91
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_7 VL

<400>  91
gtcatctgga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgat gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

ggtgattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa ac                                               322


<210>  92
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 VH

<400>  92

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Ile Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gln Tyr Ala Ile Leu Thr His Ser Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  93
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 CDRH1

<400>  93

Gly Tyr Thr Leu Ile Glu Leu Ser 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8   CDRH2 

<400>  94

Phe Asp Pro Glu Asp Ala Glu Thr 
1               5               


<210>  95
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 CDRH3 

<400>  95

Ala Thr Gln Tyr Ala Ile Leu Thr His Ser Tyr Phe Asp Tyr 
1               5                   10                  


<210>  96
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 VL

<400>  96

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  97
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 CDRL1 

<400>  97

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  98
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 CDRL2

<400>  98

Ala Ala Ser 
1           


<210>  99
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 CDRL3 

<400>  99

Gln Lys Tyr Asn Ser Ala Pro Gln Thr 
1               5                   


<210>  100
<211>  364
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 VH 

<400>  100
caggtgcagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcatt gaattatcca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatgctga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aacacaatac      300

gcaatcctta ctcattccta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  101
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_8 VL

<400>  101
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg cccctcagac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  102
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9 VH

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Asn Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asn Ala Tyr Lys Trp Leu Leu Ala Glu Asn Val Arg 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  103
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9 CDRH1 

<400>  103

Gly Phe Thr Phe Ser Asp Tyr Thr 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9 CDRH2 

<400>  104

Ile Ser Ser Ser Ser Asn Tyr Ile 
1               5               


<210>  105
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9 CDRH3 

<400>  105

Ala Arg Asp Gly Asn Ala Tyr Lys Trp Leu Leu Ala Glu Asn Val Arg 
1               5                   10                  15      


Phe Asp Tyr 
            

<210>  106
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9  VL 

<400>  106

Gln Thr Val Val Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  107
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9  CDRL1 

<400>  107

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  108
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9  CDRL2 

<400>  108

Asp Val Ser 
1           


<210>  109
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9  CDRL3

<400>  109

Ser Ser Tyr Thr Ser Ser Ser Thr Pro Asn Trp Val 
1               5                   10          


<210>  110
<211>  379
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9  VH 

<400>  110
gaggtgcagc tggtggagtc tgggggaggc ctggtcaacc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactatacca ttcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtaatta tatatactac      180

gcggactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtct      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatggt      300

aatgcctaca agtggttatt ggcagagaac gttcgttttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcag                                                   379


<210>  111
<211>  337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_9  VL

<400>  111
cagactgtgg tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtgatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacccccaat      300

tgggtgttcg gcggagggac caagctgacc gtcctag                               337


<210>  112
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10 VH

<400>  112

Gln Val Gln Leu Gln Gln Arg Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asp Val Tyr Gly Gly Ser Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Val Val Val Ile Val His Ala Leu Pro Met Pro Val Asn Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  113
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10 CDRH1 

<400>  113

Gly Gly Ser Leu Ser Gly Tyr Tyr 
1               5               


<210>  114
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10 CDRH2

<400>  114

Ile Asn His Arg Gly Ser Thr 
1               5           


<210>  115
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10 CDRH3 

<400>  115

Ala Arg Tyr Val Val Val Ile Val His Ala Leu Pro Met Pro Val Asn 
1               5                   10                  15      


Trp Phe Asp Pro 
            20  


<210>  116
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10  VL 

<400>  116

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Ala Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Cys Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Pro Leu Ile Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  117
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10 CDRL1

<400>  117

Ser Ser Asp Val Gly Ser Tyr Asn Leu 
1               5                   


<210>  118
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10  CDRL2 

<400>  118

Glu Gly Ser 
1           


<210>  119
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10  CDRL3

<400>  119

Cys Ser Tyr Ala Gly Ser Ser Pro Leu Ile Val 
1               5                   10      


<210>  120
<211>  379
<212>  DNA
<213>  Artificial sequence 

<220>
<223>  Synthetic Antibody 418_10  VH

<400>  120
caggtgcagc tacagcagcg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgatg tctatggtgg gtccctcagt ggttactact ggagctggat ccgccaggcc      120

ccagggaagg ggctggagtg gattggggaa atcaatcatc gtggaagcac caactacaac      180

ccgtccctca agagtcgggt caccatatca atagacacgt ccaagaagca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag atacgttgtg      300

gtgatcgtac atgcccttcc aatgccagtt aactggttcg acccctgggg ccagggaacc      360

ctggtcaccg tctcctcag                                                   379


<210>  121
<211>  334
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_10  VL 

<400>  121
cagtctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacaa      120

cacccagcca aagcccccaa actcatcatt tatgagggca gtaagcggcc ctcaggagtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctggactc      240

caggctgagg acgaatgtga ttattactgc tgctcatatg caggtagtag ccccttgata      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctag                                  334


<210>  122
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 VH

<400>  122

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Pro Gly Ser Trp Ala Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  123
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 CDRH1 

<400>  123

Gly Phe Ser Val Ser Ser Asn Tyr 
1               5               


<210>  124
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 CDRH2 

<400>  124

Ile Tyr Ser Gly Gly Ser Ala 
1               5           


<210>  125
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 CDRH3 

<400>  125

Ala Arg Ala Pro Gly Ser Trp Ala Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  126
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 VL(VK) 

<400>  126

Glu Ile Val Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Met Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  127
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 CDRL1 

<400>  127

Gln Ser Val Arg Ser Asn 
1               5       


<210>  128
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 CDRL2 

<400>  128

Gly Ala Ser 
1           


<210>  129
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 CDRL3 

<400>  129

Gln Gln Tyr Asn Ile Trp Pro Thr 
1               5               


<210>  130
<211>  361
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11 VH 

<400>  130
gaggtgcagc tgttggagtc tggaggaggc ttgatccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctgggtt cagcgtcagt agcaactaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagtgc atactacgca      180

gactccgtga agggccgatt caccatctcc agagacattt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agcccccggc      300

agttgggcct actggtactt cgatctctgg ggccgtggaa ccctggtcac tgtctcctca      360

g                                                                      361


<210>  131
<211>  319
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_11  VL(VK) 

<400>  131
gaaatagtga tgatgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaga agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag catgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataatatct ggccgacgtt cggccaaggg      300

accaaggtgg aaatcaaac                                                   319


<210>  132
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 VH 

<400>  132

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Glu Arg Ile Lys Met Ile Val Val Val Thr Met Ile Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  133
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 CDRH1 

<400>  133

Gly Phe Thr Phe Ser Ser His Ala 
1               5               


<210>  134
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12  CDRH2

<400>  134

Ile Ser Gly Ser Gly Gly Asp Thr 
1               5               


<210>  135
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12  CDRH3 

<400>  135

Ala Lys Gly Glu Arg Ile Lys Met Ile Val Val Val Thr Met Ile Asp 
1               5                   10                  15      


Tyr 
    

<210>  136
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 VL 

<400>  136

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  137
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 CDRL1 

<400>  137

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  138
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 CDRL2 

<400>  138

Asp Asn Asn 
1           


<210>  139
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 CDRL3 

<400>  139

Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  140
<211>  373
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 VH 

<400>  140
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agtcatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt attagtggta gtggtggtga cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ttgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggaa      300

cgtattaaaa tgatagtagt ggttactatg attgactact ggggccaggg aaccctggtc      360

accgtctcct cag                                                         373


<210>  141
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_12 VL 

<400>  141
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg agtaattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata acagcctgag tgctggggta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  142
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 VH

<400>  142

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Arg 
            20                  25                  30          


Gly Met Cys Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Phe Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Gly Val Ile Pro Ala Ala Gly Thr Val Pro Tyr 
            100                 105                 110         


Tyr His Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  143
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 CDRH1 

<400>  143

Gly Phe Ser Leu Ser Thr Arg Gly Met Cys 
1               5                   10  


<210>  144
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 CDRH2

<400>  144

Ile Asp Trp Asp Asp Asp Lys 
1               5           


<210>  145
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 CDRH3 

<400>  145

Ala Arg Ile Arg Gly Val Ile Pro Ala Ala Gly Thr Val Pro Tyr Tyr 
1               5                   10                  15      


His Tyr Met Asp Val 
            20      


<210>  146
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 VL(VK) 

<400>  146

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Leu Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    

<210>  147
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 CDRL1 

<400>  147

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  148
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 CDRL2 

<400>  148

Leu Gly Ser 
1           


<210>  149
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 CDRL3 

<400>  149

Met Gln Ala Leu Gln Thr Leu Ser Ile Thr 
1               5                   10  


<210>  150
<211>  387
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 VH

<400>  150
caggtcacct tgagggagtc tggtcctgcg ttggtgaaac ccacacagac cctcacactg       60

acctgcacct tctctgggtt ctcactcagc actcgtggaa tgtgtgtgaa ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcattcattg attgggatga tgataaatac      180

tacagcacat ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cggggggtta taccagcagc tggtacagtt ccctactacc actacatgga cgtctggggc      360

aaagggacca cggtcaccgt ctcctca                                          387


<210>  151
<211>  340
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_13 VL(VK) 

<400>  151
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactctt      300

tcgatcacct tcggccaagg gacacgactg gagattaaac                            340


<210>  152
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 VH 

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ser Tyr Asp Ser Arg Gly Tyr Tyr Pro Arg Glu 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  153
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14  
CDRH1 


<400>  153

Gly Phe Thr Phe Ser Thr Tyr Ser 
1               5               


<210>  154
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 CDRH2 

<400>  154

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  155
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 CDRH3 

<400>  155

Ala Arg Trp Gly Tyr Ser Tyr Asp Ser Arg Gly Tyr Tyr Pro Arg Glu 
1               5                   10                  15      


Leu Asp Tyr 
            


<210>  156
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 VL(VK) 

<400>  156

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys 
            100                 105             


<210>  157
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 CDRL1

<400>  157

Gln Ser Val Ser Asn Asn 
1               5       


<210>  158
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 CDRL2 

<400>  158

Gly Ala Ser 
1           


<210>  159
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 CDRL3

<400>  159

Gln His Tyr Tyr Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  160
<211>  379
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 VH

<400>  160
gaggtgcaac tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacgttcagt acctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gaggtggggt      300

tattcctatg acagtcgtgg ctattacccc cgggaacttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcag                                                   379


<210>  161
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_14 VL(VK) 

<400>  161
gatattgtga tgactcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca cggccagtca gagtgttagc aacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcac tattataact ggcctccgtg gaccttcggc      300

caagggacca acgtggaaat caaac                                            325


<210>  162
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 VH

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Leu Lys Asp Ser Arg Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  163
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 CDRH1

<400>  163

Gly Phe Thr Phe Asn Ser Tyr Gly 
1               5               


<210>  164
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 CDRH2 

<400>  164

Ile Arg Tyr Asp Gly Gly Asn Lys 
1               5               


<210>  165
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 CDRH3 

<400>  165

Ala Asn Leu Lys Asp Ser Arg Tyr Ser Gly Ser Tyr Tyr Asp Tyr 
1               5                   10                  15  


<210>  166
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 VL(VK) 

<400>  166

Val Ile Trp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Arg Phe Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Asp Ala Ser Asn Met Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Phe Lys 
            100                 105         


<210>  167
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 CDRL1

<400>  167

Gln Asp Ile Arg Phe Tyr 
1               5       


<210>  168
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 CDRL2

<400>  168

Asp Ala Ser 
1           


<210>  169
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 CDRL3


<400>  169

Gln Gln Tyr Asp Asn Leu Pro Phe Thr 
1               5                   


<210>  170
<211>  367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 VH(VK) 

<400>  170
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcaat agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaggtaa taagtactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga agagcctgag agctgaggac acggctgtgt attactgtgc gaacctgaaa      300

gatagcagat atagtgggag ctattatgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcag                                                                367


<210>  171
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_40 VL (VK) 

<400>  171
gtcatctgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagg ttctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctccgat gcatccaata tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggaccgat tttactttca ccatcagcag ccttcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccctttcac tttcggccct      300

gggaccaagg tggatttcaa ac                                               322


<210>  172
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 VH

<400>  172

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Val Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Val Ala Val Ala Gly Pro Phe Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  173
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 CDRH1 

<400>  173

Gly Tyr Thr Phe Thr Gly Tyr His 
1               5               


<210>  174
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 CDRH2 

<400>  174

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  175
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 CDRH3 

<400>  175

Ala Lys Val Val Ala Val Ala Gly Pro Phe Asp His 
1               5                   10          


<210>  176
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 VL

<400>  176

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Phe Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Asp Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  177
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 CDRL1

<400>  177

Ser Ser Asp Val Gly Ser Tyr Asn Leu 
1               5                   


<210>  178
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 CDRL2

<400>  178

Glu Gly Ser 
1           


<210>  179
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 CDRL3

<400>  179

Phe Ser Tyr Ala Gly Ser Ser Asp Trp Val 
1               5                   10  


<210>  180
<211>  358
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 VH

<400>  180
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctaccata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gtacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gaaggttgta      300

gcagtggctg gcccctttga ccactggggc cagggaaccc tggtcaccgt ctcctcag        358


<210>  181
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_15 VL

<400>  181
cagtctgtgt tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgagggca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc ttctcatatg caggtagtag tgattgggtg      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  182
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 VH

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Val Ser Ile Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Pro His Asn Tyr Asp Ser Ser Gly Tyr Tyr Pro Asp 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  183
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 CDRH1 


<400>  183

Gly Phe Thr Phe Ser Thr Tyr Ser 
1               5               


<210>  184
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 CDRH2 


<400>  184

Val Ser Ile Ser Ser Ser Tyr Ile 
1               5               


<210>  185
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 CDRH3


<400>  185

Ala Arg Val Arg Pro His Asn Tyr Asp Ser Ser Gly Tyr Tyr Pro Asp 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  186
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 VL(VK) 


<400>  186

Val Ile Trp Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Ser Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105             


<210>  187
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 CDRL1

<400>  187

Gln Ser Val Ser Ser Asn 
1               5       


<210>  188
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 CDRL2

<400>  188

Gly Ala Ser 
1           


<210>  189
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 CDRL3

<400>  189

Gln His Tyr Tyr Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  190
<211>  382
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 VH 


<400>  190
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactt       60

tcctgtgcag cctctggatt caccttcagt acctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc gttagtatta gtagtagtta catatattac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acaacgtgag agccgaggac acggccgtgt attactgtgc gagagttcgc      300

ccccataact atgatagtag tggttattat ccggatgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcttc ag                                               382


<210>  191
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_16 VL (VK) 

<400>  191
gtcatctgga tgacccagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccaccag tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcat tattataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaagt caaac                                            325


<210>  192
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 VH 

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Met Ser Arg Ser Ile Phe Ser Gly Tyr Tyr Pro Asp 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  193
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 CDRH1

<400>  193

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  194
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 CDRH2 

<400>  194

Ile Ser Ser Ser Gly Ser Tyr Ile 
1               5               


<210>  195
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 CDRH3 

<400>  195

Ala Arg Asp Leu Met Ser Arg Ser Ile Phe Ser Gly Tyr Tyr Pro Asp 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  196
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 VL(VK) 

<400>  196

Glu Ile Val Met Met Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ser Ile Ser Ser Met Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys 
            100                 105             


<210>  197
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 CDRL1

<400>  197

Gln Ser Val Ser Ser Asn 
1               5       


<210>  198
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 CDRL2

<400>  198

Gly Ala Ser 
1           


<210>  199
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 CDRL3

<400>  199

Gln His Tyr Tyr Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  200
<211>  382
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 VH

<400>  200
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt tcctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtggtagtta catatattac      180

gcagactcag tgaagggccg attcaccatc tccagagaca gcgccaagac ctcactgtat      240

ctacaaatga acagcctgag agccgaggac acggctgtgt atttctgtgc gagagatctt      300

atgagtagga gcatcttctc tggttattat cctgatgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcttc ag                                               382


<210>  201
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_17 VL (VK) 

<400>  201
gaaatagtga tgatgcagtc tccagtcacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca gcatcagcag catgcagtct      240

gaagattttg cagtttatta ctgtcagcac tattataact ggcctccgtg gacgttcggc      300

caagggacca cggtggaaat caaac                                            325


<210>  202
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 VH

<400>  202

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Arg Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gln Ser Ser Ser Gly Trp Tyr Trp Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  203
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 CDRH1 

<400>  203

Gly Phe Thr Phe Arg Ser Tyr Ser 
1               5               


<210>  204
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 CDRH2 

<400>  204

Ile Ser Arg Ser Ser Asn Tyr Ile 
1               5               


<210>  205
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 CDRH3 

<400>  205

Ala Arg Asp Leu Gln Ser Ser Ser Gly Trp Tyr Trp Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    

<210>  206
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 VL 

<400>  206

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Asn Thr 
                85                  90                  95      


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  207
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 CDRL1

<400>  207

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  208
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 CDRL2

<400>  208

Gly Asn Asn 
1           


<210>  209
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 CDRL3

<400>  209

Gln Ser Phe Asp Asn Thr His Val Val 
1               5                   


<210>  210
<211>  373
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 VH 

<400>  210
caggtacagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcatgtgcag cctctggatt caccttccgt agttatagca tacactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcttcc attagtcgta gtagtaatta catatactac      180

gcagactcag tgaagggccg attcaccgtc tccagagaca acgccaagga ctcactgtat      240

ctgcaaatga acggcctgag agccgaggac acggctgtgt attactgtgc gagagatcta      300

caatccagca gtggctggta ctgggatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctctt cag                                                         373


<210>  211
<211>  328
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_18 VL

<400>  211
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcac      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcgtttg acaacaccca tgtggtattc      300

ggcggaggga ccaagctgac cgtcctag                                         328


<210>  212
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 VH

<400>  212

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Ala Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Leu Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Val Ala Gly Thr Val Arg Leu Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  213
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 CDRH1 

<400>  213

Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr 
1               5                   


<210>  214
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 CDRH2 

<400>  214

Ile Tyr His Ser Gly Ser Ala 
1               5           


<210>  215
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 CDRH3 

<400>  215

Ala Arg Glu Ala Val Ala Gly Thr Val Arg Leu Asn Trp Phe Asp Pro 
1               5                   10                  15      


<210>  216
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 VL(VK) 

<400>  216

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Ser Gln Thr Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Ile Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  217
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 CDRL1

<400>  217

Gln Thr Ile Ser Ser Tyr 
1               5       


<210>  218
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 CDRL2

<400>  218

Gly Ala Ser 
1           


<210>  219
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 CDRL3

<400>  219

Gln Gln Ser Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  220
<211>  370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_19 VH

<400>  220
caggtccagc tacaggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc       60

acctgcgctg tctctggtta ctccatcagc agtggctatt actggggctg gatccggcag      120

cccccaggga aggggctgga gtggattggg agtatctatc atagtgggag cgcctactac      180

aacccgtccc tcaagagtcg actcaccata tcagcagaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcagac acggccgtgt attactgtgc gagagaggca      300

gtggctggta ccgtgcggct gaactggttc gacccctggg gccaggggac cctggtcacc      360

gtttcctcag                                                             370


<210>  221
<211>  322
<212>  DNA
<213>  Artificial sequence

<220> 
<223>  Synthetic Antibody 418_19VL (VK) 

<400>  221
gccatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc ggccaagtca gaccattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct catctatggt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtgaatc tgggatagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ctccattcac tttcggccct      300

gggaccaaag tggatatcaa ac                                               322


<210>  222
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 VH

<400>  222

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr His Ser Val Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Phe Gly Glu Phe Gly Arg Met Ser Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  223
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 CDRH1 

<400>  223

Gly Gly Ser Ile Ser Asn Tyr Tyr 
1               5               


<210>  224
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20
CDRH2 

<400>  224

Ile Tyr His Ser Val Ser Thr 
1               5           


<210>  225
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 CDRH3 

<400>  225

Ala Arg Asp His Arg Phe Gly Glu Phe Gly Arg Met Ser Trp Phe Asp 
1               5                   10                  15      


Pro 
    

<210>  226
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 VL(VK) 

<400>  226

Glu Ile Val Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Asn Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  227
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 CDRL1

<400>  227

Gln Ser Val Ser Ser Asn 
1               5       


<210>  228
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 CDRL2

<400>  228

Gly Ala Ser 
1           


<210>  229
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 CDRL3

<400>  229

His Gln Tyr Asn Asn Trp Pro Arg Thr 
1               5                   


<210>  230
<211>  370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 VH 

<400>  230
caggtacagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccggcagccc      120

ccagggaagg gactggaatg gattgggtat atctatcaca gtgtgagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agatcatagg      300

ttcggggagt ttgggagaat gagctggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctcag                                                             370


<210>  231
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_20 VL (VK) 

<400>  231
gaaatagtga tgatgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcaccag tataataact ggcctcggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  232
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 VH 

<400>  232

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Val His Asn Trp Asn Thr Glu Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  233
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 CDRH1 

<400>  233

Gly Gly Ser Ile Ser Asn Tyr Tyr 
1               5               


<210>  234
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 CDRH2 

<400>  234

Ile Tyr Tyr Thr Gly Ser Thr 
1               5           


<210>  235
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 CDRH3

<400>  235

Ala Arg Glu Val His Asn Trp Asn Thr Glu Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  236
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 VL(VK)

<400>  236

Gln Pro Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                85                  90                  95      


Pro Leu Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110 


<210>  237
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 CDRL1

<400>  237

Gln Ser Val Ser Ser Thr Tyr 
1               5           


<210>  238
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 CDRL2

<400>  238

Gly Ala Ser 
1           


<210>  239
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21CDRL3

<400>  239

Gln Gln Tyr Gly Gly Ser Pro Pro Leu Ile Thr 
1               5                   10      


<210>  240
<211>  364
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 VH 

<400>  240
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

agctgcactg tctctggtgg ctccatcagt aattactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca ctgggagcac ctactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagtt ctgtgaccgc tgcggacacg gccgtctatt actgtgcgag agaagttcat      300

aactggaaca cagaaaactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  241
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_21 VL (VK) 

<400>  241
cagcctgtgc tgactcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcacctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaggatt ttgcagtgta ttactgtcag cagtatggtg gctcacctcc gctgatcacc      300

ttcggccaag ggacacgact ggagattaaa c                                     331


<210>  242
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 VH 

<400>  242

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Ser Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Glu Gly Val Arg Phe Leu Glu Tyr Leu Phe Gly 
            100                 105                 110         


Thr Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  243
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 CDRH1 

<400>  243

Gly Tyr Thr Phe Thr Ser Tyr Ala 
1               5               


<210>  244
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 CDRH2 

<400>  244

Ile Asn Ala Gly Ser Gly Asn Thr 
1               5               


<210>  245
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 CDRH3 

<400>  245

Ala Arg Glu Gly Thr Glu Gly Val Arg Phe Leu Glu Tyr Leu Phe Gly 
1               5                   10                  15      


Thr Trp Phe Asp Pro 
            20      


<210>  246
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 VL(VK) 

<400>  246

Gln Ala Gly Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ile Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly His Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser His Trp Pro Glu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  247
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 CDRL1

<400>  247

Gln Ser Val Ile Ser Tyr 
1               5       


<210>  248
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 CDRL2

<400>  248

Asp Ala Ser 
1           


<210>  249
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 CDRL3

<400>  249

Gln Gln Arg Ser His Trp Pro Glu Thr 
1               5                   


<210>  250
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 VH

<400>  250
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgctg gcagtggtaa tacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagagagggg      300

accgaaggcg tacgattttt ggagtactta ttcggaacct ggttcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  251
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_22 VL (VK) 

<400>  251
caggcagggc tgactcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttatc agctacttag cctggtacca acagaaacct      120

ggccacgctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagccact ggcctgagac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  252
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 VH 

<400>  252

Gln Val Thr Leu Arg Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Asn Asp Glu Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Asp Trp Trp Ser Ser Tyr Leu Val Gly Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  253
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 CDRH1

<400>  253

Gly Phe Ser Leu Ser Asn Ala Lys Met Gly 
1               5                   10  


<210>  254
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 CDRH2

<400>  254

Ile Phe Ser Asn Asp Glu Lys 
1               5           


<210>  255
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 CDRH3 

<400>  255

Ala Arg Ile Asp Trp Trp Ser Ser Tyr Leu Val Gly Asp Tyr 
1               5                   10                  


<210>  256
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 VL 

<400>  256

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr His Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  257
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 CDRL1

<400>  257

Ser Ser Asn Ile Gly Ala Gly Tyr His 
1               5                   


<210>  258
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 CDRL2

<400>  258

Gly Asn Ser 
1           


<210>  259
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 CDRL3

<400>  259

Gln Ser Tyr Asp Ser Ser Leu Ser Val Val 
1               5                   10  


<210>  260
<211>  367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 VH

<400>  260
caggtcacct tgagggagtc tggtcctgtg ctggtaaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aatgctaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgaatga cgaaaaatcc      180

tacagcacat ctctgaagag caggctcacc atctccaagg acacctccaa aagccaggtg      240

gtccttacta tgaccaacat ggaccctgtg gacacagcca catattactg tgcacggata      300

gattggtgga gtagttattt agttggtgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcag                                                                367


<210>  261
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_23 VL 

<400>  261
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcgggttatc atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagtct gagtgtggta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  262
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 VH 

<400>  262

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Arg Gly Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Leu Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Phe Pro Ser 
            100                 105                 110         


Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  263
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 CDRH1 

<400>  263

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  264
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 CDRH2

<400>  264

Ile Ser Ser Ser Arg Gly Tyr Ile 
1               5               


<210>  265
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 CDRH3 

<400>  265

Ala Arg Trp Leu Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Phe Pro Ser 
1               5                   10                  15      


Pro Phe Asp Tyr 
            20  


<210>  266
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 VL(VK) 

<400>  266

Glu Ile Glu Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  267
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 CDRL1

<400>  267

Gln Ser Val Ser Ser Asn 
1               5       


<210>  268
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 CDRL2

<400>  268

Gly Ala Ser 
1           


<210>  269
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 CDRL3

<400>  269

Gln Gln Tyr Tyr Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  270
<211>  382
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 VH

<400>  270
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ccggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagta tgaactgggt ccgccaggct      120

ccaggaaagg ggctggagtg ggtctcatcc attagtagta gtagaggtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagatggctt      300

acatattact atgatagtag tggttatttc ccctcgcctt ttgactactg gggccaggga      360

accctggtca ccgtctcctc ag                                               382


<210>  271
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_24 VL (VK) 

<400>  271
gaaatagaga tgatgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tattataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  272
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 VH 

<400>  272

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Arg Ser Phe Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ile Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Lys Ile Thr Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro 
            100                 105                 110         


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>  273
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 CDRH1 

<400>  273

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  274
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 CDRH2

<400>  274

Ile Ser Ser Ser Arg Ser Phe Ile 
1               5               


<210>  275
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 CDRH3 

<400>  275

Ala Arg Val Lys Ile Thr Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro 
1               5                   10                  15      


Asp Ala Phe Asp Ile 
            20      


<210>  276
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 VL(VK) 


<400>  276
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Met Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  277
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 CDRL1

<400>  277

Gln Ser Val Ser Ser Asn 
1               5       


<210>  278
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 CDRL2

<400>  278

Gly Ala Ser 
1           


<210>  279
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 CDRL3

<400>  279

Gln Gln Tyr Tyr Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210>  280
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 VH 

<400>  280
gaggtgcaac tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtaggagttt catatactac      180

gcagactcag tgaagggccg aatcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagtgaaa      300

attacgaatt actatgatag tagtggttat taccctgatg cttttgatat ctggggccaa      360

gggacaatgg tcaccgtctc ttcag                                            385


<210>  281
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_25 VL (VK) 

<400>  281
gatattgtga tgactcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tgtcccagcc      180

aggttcactg gcagtgggtc tgggacagat ttcactctca ccatcagcag catgcagtct      240

gaagattttg cagtttatta ctgtcagcag tattataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  282
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 VH

<400>  282

Glu Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Gln Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Thr Ala Val Ala Gly Thr Pro Asp Leu Tyr Tyr Tyr His 
            100                 105                 110         


Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  283
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 CDRH1 

<400>  283

Gly Tyr Thr Leu Thr Glu Leu Ser 
1               5               


<210>  284
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 CDRH2 

<400>  284

Phe Asp Pro Gln Asp Ala Glu Thr 
1               5               


<210>  285
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 CDRH3 

<400>  285

Val Thr Ala Thr Ala Val Ala Gly Thr Pro Asp Leu Tyr Tyr Tyr His 
1               5                   10                  15      


Tyr Gly Leu Asp Val 
            20      


<210>  286
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 VL(VK)

<400>  286

Gln Thr Val Val Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  287
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 CDRL1

<400>  287

Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  288
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 CDRL2

<400>  288

Lys Ile Ser 
1           


<210>  289
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 CDRL3

<400>  289

Met Gln Ala Thr Gln Phe Pro Arg Thr 
1               5                   


<210>  290
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 VH 

<400>  290
gaggtgcatc tggtacaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctc aagatgctga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgt aacagcgaca      300

gcagtggctg gcaccccaga cctatactac taccactacg gtttggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210>  291
<211>  337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_26 VL (VK)

<400>  291
cagactgtgg tgacccagac tccactctcc tcaccggtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtc cacagtgatg gaaacaccta cttgagttgg      120

cttcagcaga ggccaggcca gcctccaaga ctcctaattt ataagatttc taaccggttc      180

tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgcaaatc      240

agcagggtgg aagctgagga tgtcggggtt tattactgca tgcaagctac acagtttcct      300

cgtacgttcg gccaagggac caaggtggaa atcaaac                               337


<210>  292
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 VH

<400>  292

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Cys 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Arg Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro His Thr Ser Leu Tyr Gly Asp Tyr Arg Asp Asp Tyr 
            100                 105                 110         


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  293
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 CDRH1

<400>  293

Gly Phe Thr Phe Ser Ser Cys Gly 
1               5               


<210>  294
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 CDRH2 

<400>  294

Ile Ser Arg Ser Ser Asn Tyr Ile 
1               5               


<210>  295
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 CDRH3 

<400>  295

Ala Arg Ile Pro His Thr Ser Leu Tyr Gly Asp Tyr Arg Asp Asp Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Gly Met Asp Val 
            20                  


<210>  296
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 VL(VK) 

<400>  296

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  297
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 CDRL1

<400>  297

Gln Ser Val Ser Ser Asn 
1               5       


<210>  298
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 CDRL2

<400>  298

Gly Ala Ser 
1           


<210>  299
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 CDRL3

<400>  299

Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210>  300
<211>  393
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 VH 

<400>  300
gaggtgcagc tggtggagtc tgggggaggc ctggtcaggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctgtggca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagga gtagtaatta tatatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtat attactgtgc gagaatcccc      300

cacacctcac tctacggtga ctaccgggat gattactact attactacgg tatggacgtc      360

tggggccaag ggaccacggt caccgtctcc tca                                   393


<210>  301
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_27 VL (VK) 

<400>  301
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccagactcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgct cactttcggc      300

ggagggacca aggtggagat caaac                                            325


<210>  302
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 VH

<400>  302

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Arg Ile Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Leu Pro Ser Pro Tyr Ser Gly Tyr Asp Gly Gly Phe 
            100                 105                 110         


Leu Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    

<210>  303
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 CDRH1

<400>  303

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  304
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 CDRH2 

<400>  304

Ile Ser Tyr Asp Arg Ile Asn Lys 
1               5               


<210>  305
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 CDRH3 

<400>  305

Ala Arg Asp Glu Leu Pro Ser Pro Tyr Ser Gly Tyr Asp Gly Gly Phe 
1               5                   10                  15      


Leu Tyr Tyr Phe Asp Ser 
            20          


<210>  306
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 VL(VK) 

<400>  306

Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  307
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 CDRL1

<400>  307

Gln Gly Ile Ser Ser Ala 
1               5       


<210>  308
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 CDRL2

<400>  308

Asp Ala Ser 
1           


<210>  309
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 CDRL3

<400>  309

Gln Gln Phe Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  310
<211>  388
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 VH 

<400>  310
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcta tacactgggt ccgccaggct      120

ccaggcaagg ggctagagtg ggtggcagtt atatcatatg atagaattaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgag      300

ctcccgtccc catatagtgg ctacgatggg ggatttttat actactttga ctcctggggc      360

cagggaaccc tggtcaccgt ctcctcag                                         388


<210>  311
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_28 VL (VK) 

<400>  311
aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaaactcct gatctatgat gcctccagtt tggcaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accctccgac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  312
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 VH

<400>  312

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ser Leu Ile Glu Val 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asn Val Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ala Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Phe Ala Phe Gly Ala Thr Thr Arg Asn Leu Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  313
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 CDRH1 

<400>  313

Gly Tyr Ser Leu Ile Glu Val Ser 
1               5               


<210>  314
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 CDRH2

<400>  314

Phe Asp Pro Glu Asn Val Glu Thr 
1               5               


<210>  315
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 CDRH3 

<400>  315

Ala Thr Thr Phe Ala Phe Gly Ala Thr Thr Arg Asn Leu Val Asp Tyr 
1               5                   10                  15      


<210>  316
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 VL

<400>  316

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Lys Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Thr Leu 
                85                  90                  95      


Ser Gly Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  317
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 CDRL1

<400>  317

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  318
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 CDRL2

<400>  318

Lys Asn Tyr 
1           


<210>  319
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 CDRL3

<400>  319

Ala Ala Trp Asp Asp Thr Leu Ser Gly Val Leu 
1               5                   10      


<210>  320
<211>  370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 VH

<400>  320
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata ctccctcatt gaagtatcca tgcactgggt gcgacaggct      120

cctggaaaag gacttgagtg gatgggaggt tttgatcctg aaaatgtgga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctgcaga cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc aacaaccttc      300

gccttcggag ctacaacgag gaacttagta gactactggg gccagggaac cctggtcacc      360

gtctcctcag                                                             370


<210>  321
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_29 VL 

<400>  321
tcctatgagc tgacacagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgctctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcaggtc      120

ccaggaacgg cccccaaact cctcatcttt aagaattatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acaccctgag tggtgtgcta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  322
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 VH

<400>  322

Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Ser Gly Ser Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg Pro Arg Glu Met Ile Glu Arg Asp Ser Ser Gly 
            100                 105                 110         


Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120                 125             


<210>  323
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 CDRH1

<400>  323

Gly Tyr Thr Phe Ile Ser Tyr Tyr 
1               5               


<210>  324
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 CDRH2

<400>  324

Ile Asn Pro Ser Ser Gly Ser Thr 
1               5               


<210>  325
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 CDRH3 

<400>  325

Ala Arg Asp Gly Arg Pro Arg Glu Met Ile Glu Arg Asp Ser Ser Gly 
1               5                   10                  15      


Pro Tyr Phe Asp Tyr 
            20      


<210>  326
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 VL

<400>  326

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Ser Ser Gly Thr His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  327
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 CDRL1

<400>  327

Ala Leu Pro Lys Gln Tyr 
1               5       


<210>  328
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 CDRL2

<400>  328

Lys Asp Ser 
1           


<210>  329
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 CDRL3

<400>  329

Gln Ser Thr Asp Ser Ser Gly Thr His Val Val 
1               5                   10      


<210>  330
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 VH 

<400>  330
caggtacagc tggtgcagtc tggggctgat gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcatc agttactata tgcattgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtagtggtag cacaatctac      180

gcacagaagt tccagggcag agtcaccatg accacggaca cgtccacgag cacagtttac      240

atggacttga gcagcctgac atctgaggac acggccgtgt attactgtgc gagagatggg      300

cgaccgcgag agatgatcga acgtgatagt agtgggcctt actttgacta ctggggccag      360

ggaaccctgg tcaccatctc ctcag                                            385


<210>  331
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_30 VL

<400>  331
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt gccaaagcaa tatgcttatt ggtaccagca gaagccaggc      120

caggcccctg tgctggtgat atataaagac agtgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gatgaggctg actattactg tcaatcaaca gacagcagtg gtacccacgt ggtattcggc      300

ggagggacca agctgaccgt cctag                                            325


<210>  332
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 VH

<400>  332

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Thr 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Ile Tyr Asn Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Asp Tyr Tyr Asp Phe Trp Ser Gly Tyr Ser Asp 
            100                 105                 110         


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  333
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 CDRH1 

<400>  333

Gly Gly Ser Ile Ser Ser Thr Ser Tyr Tyr 
1               5                   10  


<210>  334
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 CDRH2 

<400>  334

Ile Tyr Asn Ser Gly Ser Thr 
1               5           


<210>  335
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 CDRH3

<400>  335

Ala Arg Asp Leu Asp Tyr Tyr Asp Phe Trp Ser Gly Tyr Ser Asp Trp 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  336
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 VL

<400>  336

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Thr Gly Asn Ser Asn Asn Val Gly Asp Gln 
            20                  25                  30          


Gly Ala Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 
        35                  40                  45              


Ser Tyr Arg Asn Asn Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser 
    50                  55                  60                  


Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Thr Ser Leu 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  337
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 CDRL1

<400>  337

Ser Asn Asn Val Gly Asp Gln Gly 
1               5               


<210>  338
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 CDRL2

<400>  338

Arg Asn Asn 
1           


<210>  339
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 CDRL3

<400>  339

Ser Ala Trp Asp Thr Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  340
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 VH

<400>  340
caggtacagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agtactagtt actactggag ctggatccgg      120

cagcccgccg ggaagggact ggagtggatt gggcgtatat ataacagtgg gagcaccaac      180

tacaatccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgacctctgt gaccgccgcc gacacggccg tctattactg tgcgagagat      300

cttgactact acgatttttg gagtggttat tctgactggt acttcgatct ctggggccgt      360

ggcacccagg tcactgtctc ctcag                                            385


<210>  341
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_31 VL

<400>  341
tcctatgagc tgactcagcc accctcggtg tccaagggct tgagacagac cgccacactc       60

acctgcactg ggaacagcaa caatgttggc gaccaaggag cagcttggct gcagcagcac      120

cagggccacc ctcccaaact cctatcctac aggaataaca accggccctc agggatctca      180

gagagattct ctgcatccag gtcaggaaac acagcctccc tgaccattac tggactccag      240

cctgaggacg aggctgacta ttactgctca gcatgggaca ccagcctcag tgcttgggtg      300

ttcggcggag ggaccaaact gaccgtccta a                                     331


<210>  342
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 VH 

<400>  342

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Asp Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Trp Asp Gly Tyr Asn Leu Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  343
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 CDRH1 

<400>  343

Asp Asp Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  344
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 CDRH2 

<400>  344

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  345
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 CDRH3 

<400>  345

Ala Arg Asp Arg Gly Trp Asp Gly Tyr Asn Leu Gly Phe Asp Tyr 
1               5                   10                  15  


<210>  346
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 VL 

<400>  346

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Lys Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Met Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Asn Ser Asp Gln 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  347
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 CDRL1 

<400>  347

Lys Ile Gly Ser Lys Ser 
1               5       


<210>  348
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 CDRL2

<400>  348

Asp Asp Ser 
1           


<210>  349
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 CDRL3

<400>  349

Gln Val Trp Asp Asn Asn Ser Asp Gln Gly Val 
1               5                   10      


<210>  350
<211>  364
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 VH 

<400>  350
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acttgcactg tctctgatga ctccatcagt agttactact ggagctggat tcggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aacctgagct ctgtgaccgc tgcggacacg gccgtatatt actgtgcgag agatagagga      300

tgggatggct acaatttagg ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  351
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_33 VL

<400>  351
tcctatgagc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggata       60

acctgtgggg gaaacaagat tggaagtaaa agtgtgcact ggtaccagca gatgccaggc      120

caggccccgg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gataataata gtgaccaggg ggtgttcggc      300

ggagggacca agctgaccgt cctag                                            325


<210>  352
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 VH

<400>  352

Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Thr 
            20                  25                  30          


Gly Met Arg Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Phe Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Tyr Gly Asp His Glu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  353
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 CDRH1 

<400>  353

Gly Phe Ser Leu Ser Thr Thr Gly Met Arg 
1               5                   10  


<210>  354
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 CDRH2 

<400>  354

Ile Asp Trp Asp Asp Asp Lys 
1               5           


<210>  355
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 CDRH3 

<400>  355

Ala Arg Ala Tyr Gly Asp His Glu Asp Tyr 
1               5                   10  


<210>  356
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 VL(VK)

<400>  356

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    

<210>  357
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 CDRL1

<400>  357

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  358
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 CDRL2

<400>  358

Trp Ala Ser 
1           

<210>  359
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 CDRL3

<400>  359

Gln Gln Tyr Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  360
<211>  355
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 VH 

<400>  360
cagatcacct tgaaggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcacct tctcggggtt ctcactcagc actactggaa tgcgtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaattc      180

tacagcacat ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacaggca cgtattactg tgcacgggcc      300

tacggtgatc acgaagacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  361
<211>  340
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_34 VL(VK) 

<400>  361
gatattgtga tgactcagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ttacttagtt      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacgcgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact      300

cccatcacct tcggccaagg gacacgactg gagattaaac                            340


<210>  362
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 VH 

<400>  362

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Ser Gly Tyr Tyr Ile Phe Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  363
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 CDRH1

<400>  363

Gly Phe Thr Phe Ser Ser Tyr Glu 
1               5               


<210>  364
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 CDRH2 

<400>  364

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  365
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 CDRH3

<400>  365

Ala Arg Gly Glu Gly Ser Gly Tyr Tyr Ile Phe Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        

<210>  366
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 VL(VK) 

<400>  366

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Glu Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Ser Trp Tyr Val Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile His Glu Leu Ser Asn Arg Phe Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      


Gly Glu Lys Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  367
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 CDRL1

<400>  367

Glu Ser Leu Leu His Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  368
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 CDRL2

<400>  368

Glu Leu Ser 
1           


<210>  369
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 CDRL3

<400>  369

Met Gln Phe Gly Glu Lys Phe Thr 
1               5               


<210>  370
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 VH

<400>  370
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg gtctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggggag      300

ggcagtggct actatatttt ctactactac ggtatggacg tctggggccg agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  371
<211>  334
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_35 VL(VK)

<400>  371
gatattgtga tgactcagtc tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca agtctagtga gagcctccta catagtgatg gaaagaccta tttgtcttgg      120

tacgtgcaga agccaggcca gcctccacgg ctcctgatcc atgaactttc caaccggttc      180

cctggagtgc cagataggtt cagtggcagc gggtcagaga cagacttcac actgaggatc      240

agccgggtgg aggctgagga tgttggcgtt tattactgca tgcaattcgg ggagaaattc      300

actttcggcc ctgggaccaa agtggacatc aaac                                  334


<210>  372
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 VH

<400>  372

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asp Val Ser Gly Ala Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Thr Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Val Ser Gly Arg Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  373
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic 

<400>  373 Antibody 418_37 CDRH1 

Gly Ala Ser Ile Ser Ser Ser Asn Trp 
1               5                   


<210>  374
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 CDRH2

<400>  374

Ile Tyr His Ser Gly Asn Thr 
1               5           


<210>  375
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 CDRH3 

<400>  375

Ala Ser Arg Val Ser Gly Arg Tyr Asn Trp Phe Asp Pro 
1               5                   10              


<210>  376
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 VL

<400>  376

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Phe Ser Tyr Ala Gly Phe 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  377
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 CDRL1

<400>  377

Ser Ser Asp Val Gly Ser Tyr Asn Leu 
1               5                   


<210>  378
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 CDRL2

<400>  378

Glu Gly Ser 
1           


<210>  379
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 CDRL3

<400>  379

Phe Ser Tyr Ala Gly Phe Ser Thr Trp Val 
1               5                   10  


<210>  380
<211>  361
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 VH

<400>  380
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgatg tctctggtgc ctccatcagc agtagtaact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggaa caccaactac      180

aacccgtccc tcaagagtcg agtcaccatg tcagtagaca agtccaagaa ccagttctcc      240

ctgacggtga gctctgtgac cgccgcggac acggccgtgt actactgtgc gagccgagtt      300

tcagggaggt acaactggtt cgacccctgg ggccagggaa ccctggtcac cgtctcctca      360

g                                                                      361


<210>  381
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_37 VL

<400>  381
cagtctgtgt tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggc agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgagggca gtaagcggcc ctcaggaatt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc ttctcatatg caggttttag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  382
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 VH 

<400>  382

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ser Asp Tyr Gly Asp Tyr Ile Arg Leu Arg Arg Asn 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  383
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 CDRH1

<400>  383

Gly Phe Thr Phe Asn Asn Tyr Gly 
1               5               


<210>  384
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 CDRH2 

<400>  384

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  385
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 CDRH3 

<400>  385

Ala Arg Glu Thr Ser Asp Tyr Gly Asp Tyr Ile Arg Leu Arg Arg Asn 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  386
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 VL(VK) 

<400>  386

Glu Ile Val Met Met Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Ala Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Lys Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  387
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 CDRL1

<400>  387

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  388
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 CDRL2

<400>  388

Gly Ala Ser 
1           


<210>  389
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 CDRL3

<400>  389

Gln Gln Tyr Asp Lys Trp Pro Pro Trp Thr 
1               5                   10  


<210>  390
<211>  382
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 VH 

<400>  390
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cgtctggatt cacctttaat aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagagaca      300

agtgactacg gtgactacat acgcttgcgc aggaatgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcttc ag                                               382


<210>  391
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_38 VL(VK) 

<400>  391
gaaatagtga tgatgcagtc tccagccacc ctgtctgtgt ctccaggggc gagagtcacc       60

ctctcctgca gggccagtca gagtattagc aacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggcctctgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cttgcagtct      240

gaagattttg cagtttatta ctgtcagcag tatgataagt ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  392
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 VH

<400>  392

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Met Arg Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Cys Ser Ser Ser Asn Cys Tyr Asp Asp Ala Leu 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  393
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 CDRH1 

<400>  393

Gly Thr Ile Ser Ser Tyr Ala 
1               5           


<210>  394
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 CDRH2 

<400>  394

Ile Met Arg Ile Phe Gly Thr Pro 
1               5               


<210>  395
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 CDRH3

<400>  395

Ala Arg Glu Gly Tyr Cys Ser Ser Ser Asn Cys Tyr Asp Asp Ala Leu 
1               5                   10                  15      


Asp Ile 
        

<210>  396
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 VL 

<400>  396

Gln Pro Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Ile Gly Ile Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  397
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 CDRL1

<400>  397

Ser Gly His Ser Ser Tyr Ala 
1               5           


<210>  398
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 CDRL2

<400>  398

Leu Asn Ser Asp Gly Ser His 
1               5           


<210>  399
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 CDRL3

<400>  399

Gln Thr Trp Gly Ile Gly Ile Arg Val 
1               5                   


<210>  400
<211>  376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 VH 

<400>  400
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccatcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatgcgta tctttggtac accaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggaagga      300

tattgtagta gtagtaactg ttatgacgat gctttagata tctggggcca agggacaatg      360

gtcaccgtct cttcag                                                      376


<210>  401
<211>  334
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_39 VL

<400>  401
cagcctgtgc tgactcaatc gccctctgcc tctgcctccc tgggagcctc ggtcaagctc       60

acctgcactc tgagcagtgg gcacagcagc tacgccatcg catggcatca gcagcagcca      120

gagaagggcc ctcggtactt gatgaagctt aacagtgatg gcagccacag caagggggac      180

gggatccctg atcgcttctc aggctccagc tctggggctg agcgttacct caccatctcc      240

agcctccagt ctgaggatga ggctgactat tactgtcaga cgtggggcat tggcattcgg      300

gtattcggcg gagggaccaa actgaccgtc ctag                                  334


<210>  402
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 VH 

<400>  402

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser Pro Ala Val Val Arg Lys Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  403
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 CDRH1 

<400>  403

Gly Tyr Thr Leu Pro Glu Leu Ser 
1               5               


<210>  404
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 CDRH2 

<400>  404

Phe Asp Pro Glu Asp Gly Glu Thr 
1               5               


<210>  405
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 CDRH3 

<400>  405

Ala Thr Ser Pro Ala Val Val Arg Lys Asn Trp Phe Asp Pro 
1               5                   10                  


<210>  406
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 VL 

<400>  406

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Asp Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  407
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 CDRL1

<400>  407

Lys Leu Gly Asp Lys Asp 
1               5       


<210>  408
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 CDRL2

<400>  408

Glu Asp Asn 
1           


<210>  409
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 CDRL3

<400>  409

Gln Ala Trp Asp Ser Ser Thr His Val Val 
1               5                   10  


<210>  410
<211>  364
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 VH 

<400>  410
gaggtgcagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctccct gaattatcca tacactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctat      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga ccagcctgag atctgacgac acggccgtct attactgtgc aacctccccg      300

gctgtggtac gaaagaactg gttcgacccc tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  411
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_41 VL 

<400>  411
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agctagcatc       60

acctgctctg gagataaatt gggggataaa gatgcctgct ggtatcagca gaagccaggc      120

cagtcccctg tgctggtcat ctatgaagat aacaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ctcatgtggt attcggcgga      300

gggaccaagc tgaccgtcct ag                                               322


<210>  412
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 VH

<400>  412

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp His Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Asn Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ile Val Gly Met Val Arg Gly Val Ile Leu Leu Trp 
            100                 105                 110         


Tyr Phe Asp Pro Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  413
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 CDRH1 

<400>  413

Gly Asp Ser Ile Ser Ser Gly Asp His Tyr 
1               5                   10  


<210>  414
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 CDRH2 

<400>  414

Ile Tyr Tyr Ser Gly Asn Thr 
1               5           


<210>  415
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 CDRH3 

<400>  415

Ala Arg Ala Ile Val Gly Met Val Arg Gly Val Ile Leu Leu Trp Tyr 
1               5                   10                  15      


Phe Asp Pro 
            

<210>  416
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 VL

<400>  416

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Asn Arg Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ile Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  417
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 CDRL1

<400>  417

Arg Ser Asn Ile Gly Asn Asn Tyr 
1               5               


<210>  418
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 CDRL2

<400>  418

Asp Ile Asn 
1           


<210>  419
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 CDRL3

<400>  419

Gly Thr Trp Asp Ser Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  420
<211>  382
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 VH 

<400>  420
caggtgcagc tacaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtga ctccatcagc agtggtgatc actactggag ttggatccgc      120

cagcccccag ggaagggcct ggagtggatt ggttacatct attacagtgg caacacctac      180

tacaacccgt ccctcaagag tcgacttacc atatcagtag acacgtccaa taatcagttc      240

tccctgaagc tgagctctgt gactgccgca gacacggccg tgtattactg tgccagagca      300

atcgtgggta tggttcgggg agttattctt ctctggtact tcgatccctg gggccgtggc      360

accctggtca ctgtctcctc ag                                               382


<210>  421
<211>  331
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_42 VL

<400>  421
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaaacagatc caacataggg aataattatg tatcctggta ccagcagttc      120

ccaggaacag cccccaaact cctcatttat gacattaata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tggtcctgta      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  422
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 VH

<400>  422

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asp Thr Phe Met Val Pro Tyr Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  423
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 CDRH1 

<400>  423

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  424
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 CDRH2 

<400>  424

Ile Ser Gly Asp Gly Gly Ser Thr 
1               5               


<210>  425
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 CDRH3

<400>  425

Ala Lys Gly Asp Thr Phe Met Val Pro Tyr Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  426
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 VL(VK)

<400>  426

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  427
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 CDRL1

<400>  427

Gln Ser Ile Ser Ser Arg 
1               5       


<210>  428
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 CDRL2

<400>  428

Asp Ala Ser 
1           

<210>  429
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 CDRL3

<400>  429

Gln Gln Arg Ser Asn Trp Pro Gly Thr 
1               5                   


<210>  430
<211>  367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 VH

<400>  430
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatct attagtggtg atggtggtag cacatattac      180

gcagactccg tgaagggccg gttcaccgtc tccagagaca attccaagaa cacggtatat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtat attactgtgc gaaaggggat      300

acatttatgg ttccgtacaa ctggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctcag                                                                367


<210>  431
<211>  322
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_43 VL(VK)

<400>  431
gaaattgtgc tgactcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc agccgcttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcgg cctagagcct      240

gaagattttg ctgtttatta ctgtcagcag cgtagcaact ggccggggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  432
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 VH 

<400>  432

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Ser Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr His Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Leu Tyr Tyr Tyr Asp Ser Ser Gly Tyr Ser Ile Gly Gly Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  433
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 CDRH1

<400>  433

Gly Gly Ser Ile Ser Ser Asp Tyr 
1               5               


<210>  434
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 CDRH2  

<400>  434

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  435
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 CDRH3

<400>  435

Ala Arg Leu Leu Tyr Tyr Tyr Asp Ser Ser Gly Tyr Ser Ile Gly Gly 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  436
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 VL 

<400>  436

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Ala Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ser Thr Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  437
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 CDRL1

<400>  437

Ala Leu Ala Lys Gln Tyr 
1               5       


<210>  438
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 CDRL2

<400>  438

Lys Asp Thr 
1           


<210>  439
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 CDRL3

<400>  439

Gln Ser Ala Asp Ser Ser Ser Thr Tyr Val Val 
1               5                   10      


<210>  440
<211>  379
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 VH

<400>  440
gaggtgcagc tgcaagagtc gggcccagga ctggtgaagt cttcggagac cctgtccctc       60

acttgcactg tctctggtgg ctccatcagt agtgactact ggaattggat tcggcagccc      120

ccagggaagg gaccggagtg gattgggtat atctattaca gtgggagcac ccactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagagcca gttctcccta      240

aagctgagct ctgtgaccgc tgcggacacg gccgtctatt actgtgcgag gcttttatat      300

tactatgata gtagtggtta ttccatagga ggtgcttttg atatctgggg ccaagggaca      360

atggtcaccg tctcttcag                                                   379


<210>  441
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Antibody 418_44 VL

<400>  441
tcctatgagc tgacacagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt ggcaaagcaa tatgcttatt ggtaccaaca gaagccaggc      120

caggcccctg tgctggtgat atataaagac actgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcagtt ctacttatgt ggtattcggc      300

ggagggacca ggctgaccgt cctag                                            325


<210>  442
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb VH 

<400>  442

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
            100                 105                 110         


Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  443
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb CDRH1 

<400>  443

Gly Tyr Pro Phe Thr Ser Tyr Gly 
1               5               


<210>  444
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb CDRH2 

<400>  444

Ile Ser Thr Tyr Asn Gly Asn Thr 
1               5               


<210>  445
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb CDRH3 

<400>  445

Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
1               5                   10                  15      


Gly Phe Asp Asn 
            20  


<210>  446
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb VL (VK) 

<400>  446

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  447
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb CDRL1 

<400>  447

Gln Thr Val Ser Ser Thr Ser 
1               5           


<210>  448
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb CDRL2 

<400>  448

Gly Ala Ser 
1           


<210>  449
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 mAb CDRL3 

<400>  449

Gln Gln His Asp Thr Ser Leu Thr 
1               5               


<210>  450
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb VH 

<400>  450

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  451
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb CDRH1 

<400>  451

Gly Phe Thr Phe Thr Ser Ser Ala 
1               5               


<210>  452
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb CDRH2 

<400>  452

Ile Val Val Gly Ser Gly Asn Thr 
1               5               


<210>  453
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb CDRH3 

<400>  453

Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile 
1               5                   10                  15      


<210>  454
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb VL(VK) 

<400>  454

Asp Ile Val Leu Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Leu Thr 
                85                  90                  95      


Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  455
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb CDRL1

<400>  455

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  456
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb CDRL2 

<400>  456

Gly Ala Ser 
1           


<210>  457
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2E12 mAb CDRL3 

<400>  457

Gln Gln Tyr Val Gly Leu Thr Gly Trp Thr 
1               5                   10  


<210>  458
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb VH 

<400>  458

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Ser Gly Thr Ser Tyr Ala Gln Thr Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Pro Phe Tyr Asp Phe Trp Ser Gly Tyr Ser Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  459
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb CDRH1

<400>  459

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  460
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb CDRH2 

<400>  460

Ile Asn Pro Ile Ser Ser Gly Thr 
1               5               


<210>  461
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb CDRH3 

<400>  461

Ala Arg Ala Ala Pro Phe Tyr Asp Phe Trp Ser Gly Tyr Ser Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        

<210>  462
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb VL(VK) 

<400>  462

Glu Ile Val Met Met Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ala 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  463
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb CDRL1 

<400>  463

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  464
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb CDRL2 

<400>  464

Gly Ala Ser 
1           


<210>  465
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S2M11 mAb CDRL3 

<400>  465

Gln Gln Tyr Gly Ser Ser Ala Trp Thr 
1               5                   


<210>  466
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 N55Q mAb VH 

<400>  466

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Gln Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
            100                 105                 110         


Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  467
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SARS-CoV-2 S309 N55Q mAb CDRH2 

<400>  467

Ile Ser Thr Tyr Gln Gly Asn Thr 
1               5               


