                         SEQUENCE LISTING


<110>  Zoetis Services LLC
       Bergeron, Lisa Marie
       Campos, Henry Luis	
 
<120>  CANINE ANTIBODY VARIANTS

<130>  ZP000358A-PCT

<150   63/084241
<151>  2020-09-28

<160>  120    

<170>  PatentIn version 3.5

<210>  1
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  1

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His His His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  2
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  2

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  3
<211>  1005
<212>  DNA
<213>  Canis familiaris

<400>  3
gccagcacca cagctccctc cgtgttcccc ctggctccta gctgcggctc tacctccggc       60

agcacagtgg ccctggcttg tctggtgtcc ggctacttcc ctgagccagt gaccgtgagc      120

tggaactccg gctccctgac ctccggagtg cacacatttc caagcgtgct gcagtcttcc      180

ggcctgtatt ctctgagctc tatggtgacc gtgccttcca gcaggtggcc atctgagaca      240

ttcacctgca acgtggccca tcccgcttcc aagacaaagg tggacaagcc cgtgcctaag      300

agggagaatg gaagggtgcc ccggccccct gattgcccta agtgtccagc tccagagatg      360

ctgggaggac catccgtgtt catctttcca cccaagccca aggataccct gctgatcgct      420

agaacccctg aggtgacatg cgtggtggtg gacctggatc cagaggaccc cgaggtgcag      480

atctcttggt tcgtggatgg caagcagatg cagaccgcca agacacagcc tagggaggag      540

cagtttaacg gcacctacag ggtggtgtcc gtgctgccaa tcggccacca ggactggctg      600

aagggcaagc agtttacctg caaggtgaac aataaggctc tgccttctcc aatcgagaga      660

acaatctcca aggccagggg ccaggctcat cagcctagcg tgtacgtgct gcctccatcc      720

agagaggagc tgagcaagaa caccgtgtct ctgacatgtc tgatcaagga tttctttccc      780

cctgacatcg atgtggagtg gcagagcaat ggccagcagg agccagagtc taagtatcgc      840

accacaccac cccagctgga cgaggatggc agctacttcc tgtatagcaa gctgtctgtg      900

gacaagtcta gatggcagcg cggcgatacc tttatctgtg ccgtgatgca cgaggcactg      960

cacaatcact acacccagga gagtctgagc cacagcccag gaaaa                     1005


<210>  4
<211>  1005
<212>  DNA
<213>  Canis familiaris

<400>  4
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc       60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt      120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt      180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact      240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc cgtgcctaaa      300

agggagaatg gaagggtgcc aagaccacct gattgcccta agtgtccagc tccagaaatg      360

ctgggaggac caagcgtgtt catctttcca cccaagccca aagacacact gctgattgct      420

agaactcccg aggtgacctg cgtggtggtg gacctggatc cagaggaccc cgaagtgcag      480

atctcctggt tcgtggatgg gaagcagatg cagacagcca aaactcagcc tcgggaggaa      540

cagtttaacg gaacctatag agtggtgtct gtgctgccaa ttggacacca ggactggctg      600

aagggcaaac agtttacatg caaggtgaac aacaaggccc tgcctagtcc aatcgagagg      660

actatttcaa aagctagggg acaggctcat cagccttccg tgtatgtgct gcctccatcc      720

cgggaggaac tgtctaagaa cacagtgagt ctgacttgtc tgatcaaaga tttctttccc      780

cctgacattg atgtggagtg gcagagcaat gggcagcagg agccagaatc caagtacaga      840

accacaccac cccagctgga cgaagatggc tcctatttcc tgtacagtaa gctgtcagtg      900

gacaaatcta ggtggcagcg cggggatacc tttatctgcg ccgtgatgca cgaggctctg      960

cacaatcatt acacacaaga aagtctgtca catagccccg gcaag                     1005


<210>  5
<211>  96
<212>  PRT
<213>  Canis familiaris

<400>  5

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


<210>  6
<211>  20
<212>  PRT
<213>  Canis familiaris

<400>  6

Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
1               5                   10                  15      


Pro Lys Cys Pro 
            20  


<210>  7
<211>  110
<212>  PRT
<213>  Canis familiaris

<400>  7

Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
65                  70                  75                  80  


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
            100                 105                 110 


<210>  8
<211>  109
<212>  PRT
<213>  Canis familiaris

<400>  8

Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
            20                  25                  30          


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
        35                  40                  45              


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
    50                  55                  60                  


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
65                  70                  75                  80  


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
                85                  90                  95      


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
            100                 105                 


<210>  9
<211>  291
<212>  DNA
<213>  Canis familiaris

<400>  9
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc       60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt      120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt      180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact      240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc c               291


<210>  10
<211>  57
<212>  DNA
<213>  Canis familiaris

<400>  10
gtgcctaaaa gggagaatgg aagggtgcca agaccacctg attgccctaa gtgtcca          57


<210>  11
<211>  330
<212>  DNA
<213>  Canis familiaris

<400>  11
gctccagaaa tgctgggagg accaagcgtg ttcatctttc cacccaagcc caaagacaca       60

ctgctgattg ctagaactcc cgaggtgacc tgcgtggtgg tggacctgga tccagaggac      120

cccgaagtgc agatctcctg gttcgtggat gggaagcaga tgcagacagc caaaactcag      180

cctcgggagg aacagtttaa cggaacctat agagtggtgt ctgtgctgcc aattggacac      240

caggactggc tgaagggcaa acagtttaca tgcaaggtga acaacaaggc cctgcctagt      300

ccaatcgaga ggactatttc aaaagctagg                                       330


<210>  12
<211>  327
<212>  DNA
<213>  Canis familiaris

<400>  12
ggacaggctc atcagccttc cgtgtatgtg ctgcctccat cccgggagga actgtctaag       60

aacacagtga gtctgacttg tctgatcaaa gatttctttc cccctgacat tgatgtggag      120

tggcagagca atgggcagca ggagccagaa tccaagtaca gaaccacacc accccagctg      180

gacgaagatg gctcctattt cctgtacagt aagctgtcag tggacaaatc taggtggcag      240

cgcggggata cctttatctg cgccgtgatg cacgaggctc tgcacaatca ttacacacaa      300

gaaagtctgt cacatagccc cggcaag                                          327



<210>  13
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  13

Tyr Tyr Asp Ile Asn 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  14

Asn Tyr Gly Met Ser 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  15

Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe Lys 
1               5                   10                  15      


Gly 
    
    
<210>  16
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  16

Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile Lys 
1               5                   10                  15      


Gly 
    

<210>  17
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  17

Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr 
1               5                   10                  


<210>  18
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  18

Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr 
1               5                   10      


<210>  19
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  19

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  
    

<210>  20
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  20

Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Gly Leu Met His 
1               5                   10                  15  


<210>  21
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  21

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  22

Arg Ala Ser Asn Leu Glu Ala 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Gln Gln Ser Asn Lys Asp Pro Leu Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Gln Ser Arg Glu Tyr Pro Trp Thr 
1               5                   


<210>  25
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  26
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  26

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  27
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  27

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

    

<210>  28
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  29

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Tyr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable heavy chain mAb sequence, from Mus musculus 
       and Canis

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Lys Tyr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     



<210>  32
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  33
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable heavy chain mAb sequence, from Mus musculus 
       and Canis

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  34
<211>  159
<212>  PRT
<213>  Canis familiaris

<400>  34

Met Leu Ser His Thr Gly Pro Ser Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Ser Met Glu Thr Leu Leu Ser Ser His Met Ala Pro Thr His Gln Leu 
            20                  25                  30          


Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln 
145                 150                 155                 


<210>  35
<211>  477
<212>  DNA
<213>  Canis familiaris

<400>  35
atgctctccc acacaggacc atccaggttt gccctgttcc tgctctgctc tatggaaacc       60

ttgctgtcct cccatatggc acccacccat cagctaccac caagtgatgt acgaaaaatc      120

atcttggaat tacagccctt gtcgagggga cttttggaag actatcagaa gaaagagaca      180

ggggtgccag aatccaaccg taccttgctg ctgtgtctca cctctgattc ccaaccacca      240

cgcctcaaca gctcagccat cttgccttat ttcagggcaa tcagaccatt atcagataag      300

aacattattg ataaaatcat agaacagctt gacaaactca aatttcaaca tgaaccagaa      360

acagaaattt ctgtgcctgc agatactttt gaatgtaaaa gcttcatctt gacgatttta      420

cagcagttct cggcgtgcct ggaaagtgtg tttaagtcac taaactctgg acctcag         477


<210>  36
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  36
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggaga ctgatgatgt tgcaacctat tactgtcagc aaagtaataa ggatccgctc      300

acgttcggtg ctgggaccaa gctggagctg aaa                                   333


<210>  37
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  37
caggttcagc tgcagcagtc tggagctgaa ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcaaa tactatgata taaactgggt gaggcagagg      120

cctgaacagg gacttgagtg gattggatgg atttttcctg gagatggtgg tactaagtac      180

aatgagacgt tcaagggcaa ggccacactg actacagaca aatcctccag cacagcctac      240

atgcagctca gcaggctgac atctgaggac tctgctgtct atttctgtgc aagagggggg      300

acttcggtga taagggatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  38
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  38
gacattttgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccatc       60

atctcctgca aggccagcca aagtgtcagt tttgctggta ctggtttaat gcactggtac      120

caacagaaac caggacagca acccaaactc ctcatctatc gtgcatccaa cctagaagct      180

ggggttccta ccaggtttag tggcagtggg tctaggacag acttcaccct caatatccat      240

cctgtggagg aggaggatgc tgcaacctat ttctgtcagc aaagcaggga atatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  39
<211>  353
<212>  DNA
<213>  Mus musculus

<400>  39
gaggtgcagt tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt ctctttcagt aactatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagttatg gtggtagtta cacctactat      180

ccagacaata taaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgt aagggggtat      300

ggttacgata ctatggacta ctggggtcaa ggaacctcag tcaccgtctc gag             353


<210>  40
<211>  331
<212>  PRT
<213>  Canis familiaris

<400>  40

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val 
            100                 105                 110         


Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
145                 150                 155                 160 


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln 
                165                 170                 175     


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln 
            180                 185                 190         


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp 
        195                 200                 205             


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala 
    210                 215                 220                 


His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His Tyr 
305                 310                 315                 320 


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  41
<211>  993
<212>  DNA
<213>  Canis familiaris

<400>  41
gcctccacca cggcgccctc ggttttccca ctggccccca gctgcgggtc cacttccggc       60

tccacggtgg ccctggcctg cctggtgtca ggctacttcc ccgagcctgt aactgtgtcc      120

tggaactccg gctccttgac cagcggtgtg cacaccttcc cgtccgtcct gcagtcctca      180

gggcttcact ccctcagcag catggtgaca gtgccctcca gcaggtggcc cagcgagacc      240

ttcacctgca acgtggtcca cccagccagc aacactaaag tagacaagcc agtgttcaat      300

gaatgcagat gcactgatac acccccatgc ccagtccctg aacctctggg agggccttcg      360

gtcctcatct ttcccccgaa acccaaggac atcctcagga ttacccgaac acccgaggtc      420

acctgtgtgg tgttagatct gggccgtgag gaccctgagg tgcagatcag ctggttcgtg      480

gatggtaagg aggtgcacac agccaagacc cagtctcgtg agcagcagtt caacggcacc      540

taccgtgtgg tcagcgtcct ccccattgag caccaggact ggctcacagg gaaggagttc      600

aagtgcagag tcaaccacat agacctcccg tctcccatcg agaggaccat ctctaaggcc      660

agagggaggg cccataagcc cagtgtgtat gtcctgccgc catccccaaa ggagttgtca      720

tccagtgaca cagtcagcat cacctgcctg ataaaagact tctacccacc tgacattgat      780

gtggagtggc agagcaatgg acagcaggag cccgagagga agcaccgcat gaccccgccc      840

cagctggacg aggacgggtc ctacttcctg tacagcaagc tctctgtgga caagagccgc      900

tggcagcagg gagacccctt cacatgtgcg gtgatgcatg aaactctaca gaaccactac      960

acagatctat ccctctccca ttctccgggt aaa                                   993


<210>  42
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  42

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  43
<211>  1005
<212>  DNA
<213>  Canis familiaris

<400>  43
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc       60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt      120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt      180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact      240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc cgtgcctaaa      300

agggagaatg gaagggtgcc aagaccacct gattgcccta agtgtccagc tccagaaatg      360

ctgggaggac caagcgtgtt catctttcca cccaagccca aagacacact gctgattgct      420

agaactcccg aggtgacctg cgtggtggtg gacctggatc cagaggaccc cgaagtgcag      480

atctcctggt tcgtggatgg gaagcagatg cagacagcca aaactcagcc tcgggaggaa      540

cagtttaacg gaacctatag agtggtgtct gtgctgccaa ttggacacca ggactggctg      600

aagggcaaac agtttacatg caaggtgaac aacaaggccc tgcctagtcc aatcgagagg      660

actatttcaa aagctagggg acaggctcat cagccttccg tgtatgtgct gcctccatcc      720

cgggaggaac tgtctaagaa cacagtgagt ctgacttgtc tgatcaaaga tttctttccc      780

cctgacattg atgtggagtg gcagagcaat gggcagcagg agccagaatc caagtacaga      840

accacaccac cccagctgga cgaagatggc tcctatttcc tgtacagtaa gctgtcagtg      900

gacaaatcta ggtggcagcg cggggatacc tttatctgcg ccgtgatgca cgaggctctg      960

cacaatcatt acacacaaga aagtctgtca catagccccg gcaag                     1005


<210>  44
<211>  106
<212>  PRT
<213>  Canis familiaris

<400>  44

Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
1               5                   10                  15      


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
        35                  40                  45              


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
65                  70                  75                  80  


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
                85                  90                  95      


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys 
            100                 105     


<210>  45
<211>  318
<212>  DNA
<213>  Canis familiaris

<400>  45
aggaacgacg cccagcctgc tgtgtatctg tttcagccct cccctgatca gctgcacact       60

ggctctgcta gtgtggtgtg tctgctgaac agcttctacc caaaggatat caatgtgaag      120

tggaaagtgg acggcgtgat ccaggatact gggattcagg agtccgtgac cgaacaggac      180

aaagattcaa catatagcct gagctccact ctgaccatgt ctagtaccga gtacctgagc      240

cacgaactgt attcctgcga gatcactcat aagtccctgc cctctaccct gatcaagagc      300

ttccagagat cagagtgt                                                    318





<210>  46
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  46
gagatcgtga tgacccagag ccccgccagc ctgagcctga gccaggaaga gaaagtcacc       60

atcacatgca aggccagcca gagcgtgtcc ttcgccggca caggcctgat gcactggtat      120

cagcagaagc ccggccaggc ccccaagctg ctgatctacc gggccagcaa cctggaagcc      180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg acttcagctt caccatcagc      240

agcctcgaac ccgaggacgt ggccgtgtac tactgccagc agagcagaga gtacccctgg      300

accttcggcc agggtaccaa gctggagatc aag                                   333


<210>  47
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable heavy chain mAb
       sequence, from Mus musculus and Canis

<400>  47
gaggtgcagc tggtggaatc tggcggcgac ctggtcaagc ctggcggcag cctgagactg       60

agctgtgtgg ccagcggctt caccttcagc aactacggca tgagctgggt ccgacaggcc      120

cctggcaagg gactgcagtg ggtggccacc atcagctacg gcggcagcta cacctactac      180

cccgacaaca tcaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccatgt actactgcgt gcggggctac      300

ggctacgaca caatggacta ctggggccag ggcaccctcg tgaccgtctc gagc            354


<210>  48
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  48
gatatagtga tgacacaaac tcctctcagt ctttccgtat caccgggaga accggcttcc       60

atttcctgtc gggcctcaga gtctgtggac aactacggga tatccttcat gcactggtat      120

cagcagaaac ccggccagcc ccctaaactc cttatttaca gggccagtaa tctggaaagc      180

ggtgtgcccg atcgatttag cggttccggg agcggcacag atttcaccct gcgaatctct      240

agagttgaag cggatgatgc aggagtatat tactgccagc aatccaataa ggatcccctt      300

acattcggcg cgggtaccaa gctggagatc aag                                   333


<210>  49
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable heavy chain mAb
       sequence, from Mus musculus and Canis

<400>  49
gaggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg       60

tcctgcaaga ccagcggcta caccttcaag tactacgaca tcaactgggt ccgacaggcc      120

cctggcgccg gactggattg gatgggctgg atcttccccg gcgacggcgg caccaagtac      180

aacgagacat tcaagggcag agtgaccctg accgccgaca ccagcaccag caccgcctac      240

atggaactga gcagcctgag agccggcgat atcgctgtgt actactgcgc cagaggcggc      300

accagcgtga tccgggacgc tatggactac tggggccagg gcaccctcgt gaccgtctcg      360

agc                                                                    363


<210>  50
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  50
gacattgtta tgactcagac gcccctgagc ctgagcgtct cccccggcga gcccgctagt       60

attagttgcc gggcatccga gtcagtggac aattatggca tcagctttat gcattggttt      120

cagcagaaac caggtcagtc ccctcaactc ctgatttaca gagcttccaa tctggaatca      180

ggcgttcctg acagatttag cggatcaggc tccgggacag atttcaccct gcgcatcagt      240

cgcgtggaag ccgatgacgc aggcgtctat tattgtcaac agtccaacaa ggatcccctt      300

acattcggag ccggtaccaa gctggagatc aag                                   333


<210>  51
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  51

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Arg Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  52
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  52
gacatcgtga tgacccagac ccccctgagc ctgagcgtgt cccctggcga gcctgccagc       60

atcagctgca gagccagcga gagcgtggac aactacggca tcagcttcat gcactggttc      120

cagcagaagc ccggccagag cccccagcgg ctgatctaca gagccagcaa cctggaaagc      180

ggcgtgcccg atcggtttag cggctctggc agcggcaccg acttcaccct gcggatctct      240

cgggtggaag ccgatgacgc cggagtgtac tactgccagc agagcaacaa ggaccccctg      300

acctttggcg ccggtaccaa gctggagatc aag                                   333


<210>  53
<211>  148
<212>  PRT
<213>  Artificial

<220>
<223>  canine IL-31 full length protein encoded by codon-optimized 
       nucleotide sequence

<400>  53

Met Arg Gly Ser His His His His His His Gly Ser Ser His Met Ala 
1               5                   10                  15      


Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu 
            20                  25                  30          


Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu 
        35                  40                  45              


Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser 
    50                  55                  60                  


Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe 
65                  70                  75                  80  


Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile 
                85                  90                  95      


Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile 
            100                 105                 110         


Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile 
        115                 120                 125             


Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn 
    130                 135                 140                 


Ser Gly Pro Gln 
145             


<210>  54
<211>  444
<212>  DNA
<213>  Artificial

<220>
<223>  codon-optimized nucleotide sequence encoding canine IL-31 
       full-length protein

<400>  54
atgagaggat cccatcacca tcaccaccac ggctcatctc atatggctcc tactcaccaa       60

ttaccaccct ccgatgtccg taaaattatt ctcgaattac aacctttatc ccgcggtctg      120

ctcgaagatt accaaaaaaa agaaacaggc gtcccagaaa gcaaccgtac attactcctt      180

tgccttacct ccgattccca accacctcgt cttaactcat cagccattct cccttatttc      240

cgtgccattc gccctctttc tgataaaaat attattgaca aaattattga acaactcgac      300

aaattaaaat tccaacacga acccgaaacc gaaatctccg tacctgccga tacctttgaa      360

tgcaaatcct ttatcctcac tattttacaa caattctccg catgtctcga atccgtcttc      420

aaatctctca attccggtcc acag                                             444


<210>  55
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZTS-841 Heavy Chain Variable Region

<400>  55
gaggtgcagc tggtggagtc tgggggagat ttggtgaagc ctggggggtc cttgagactg       60

tcctgtgtgg cctctggatt caccttcagt agccacggca tgcactgggt ccgtcagtct      120

ccagggaagg gactgcagtg ggtcgcagtt attaacagcg gtggaagtag cacatactac      180

acagacgctg tgaagggccg attcaccatc tccagagaca acgccaagaa cacagtgtat      240

ctacagatga acagcctgag agccgaggac acggccatgt attactgtgc aaaggagtcc      300

gtcggggggt gggagcaact ggtcggacct cattttgact actggggcca gggaaccctg      360

gtcatcgtct cgagc                                                       375


<210>  56
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS-841 Heavy Chain Variable Region

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Val Ile Asn Ser Gly Gly Ser Ser Thr Tyr Tyr Thr Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ser Val Gly Gly Trp Glu Gln Leu Val Gly Pro His Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser 
        115                 120                 125 


<210>  57
<211>  8
<212>  PRT
<213>  Canis familiaris

<400>  57

Gly Phe Thr Phe Ser Ser His Gly 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Canis familiaris

<400>  58

Ile Asn Ser Gly Gly Ser Ser Thr 
1               5               


<210>  59
<211>  18
<212>  PRT
<213>  Canis familiaris

<400>  59

Ala Lys Glu Ser Val Gly Gly Trp Glu Gln Leu Val Gly Pro His Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  60
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZTS-841 Light Chain Variable Region

<400>  60
cagtctgtgc tgactcagcc gacctcagtg tcagggtccc ttggccagag ggtcaccatc       60

tcctgctctg gaagcacgaa caacatcggt attcttggtg cgagctggta ccaactgttc      120

ccaggaaagg cccctaaact cctcgtgtac ggtaatggga atcgaccgtc aggggtccct      180

gaccggtttt ccggcgccga ctctggcgac tcagtcaccc tgaccatcac tgggcttcag      240

gctgaggacg aggctgatta ttactgccag tcctttgata ccacgcttgg tgctcatgtg      300

ttcggcggag gcacccacct gaccgtcctt                                       330


<210>  61
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS-841 Light Chain Variable Region

<400>  61

Gln Ser Val Leu Thr Gln Pro Thr Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Asn Asn Ile Gly Ile Leu 
            20                  25                  30          


Gly Ala Ser Trp Tyr Gln Leu Phe Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Val Tyr Gly Asn Gly Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ala Asp Ser Gly Asp Ser Val Thr Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Thr Thr Leu 
                85                  90                  95      


Gly Ala His Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110 


<210>  62
<211>  8
<212>  PRT
<213>  Canis familiaris

<400>  62

Thr Asn Asn Ile Gly Ile Leu Gly 
1               5               


<210>  63
<211>  4
<212>  PRT
<213>  Canis familiaris

<400>  63

Gly Asn Gly Asn 
1               


<210>  64
<211>  11
<212>  PRT
<213>  Canis familiaris

<400>  64

Gln Ser Phe Asp Thr Thr Leu Gly Ala His Val 
1               5                   10      


<210>  65
<211>  109
<212>  PRT
<213>  Canis familiaris

<400>  65

Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
            20                  25                  30          


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
        35                  40                  45              


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
    50                  55                  60                  


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
65                  70                  75                  80  


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His His 
                85                  90                  95      


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
            100                 105                 


<210>  66
<211>  11
<212>  PRT
<213>  Canis familiaris

<400>  66

His Glu Ala Leu His His His Tyr Thr Gln Glu 
1               5                   10      


<210>  67
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZTS-00008183 Light Chain

<400>  67
gagatcgtga tgacccagag ccccgccagc ctgagcctga gccaggaaga gaaagtcacc       60

atcacatgca aggccagcca gagcgtgtcc ttcgccggca caggcctgat gcactggtat      120

cagcagaagc ccggccaggc ccccaagctg ctgatctacc gggccagcaa cctggaagcc      180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg acttcagctt caccatcagc      240

agcctcgaac ccgaggacgt ggccgtgtac tactgccagc agagcagaga gtacccctgg      300

accttcggcc agggtaccaa gctggaaatc aagcggaacg acgcccagcc cgccgtgtac      360

ctgttccagc ccagccccga tcagctgcac accggcagcg cttcagtcgt ctgcctgctg      420

aacagcttct accccaagga catcaacgtg aagtggaagg tggacggcgt gatccaggac      480

accggcatcc aggaaagcgt caccgagcag gacaaggaca gcacctacag cctgagcagc      540

accctgacca tgtccagcac cgagtacctg agccacgagc tgtatagctg cgagatcacc      600

cacaagagcc tgcctagcac cctgatcaag agcttccagc ggagcgagtg ctagtag         657


<210>  68
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS-00008183 Light Chain

<400>  68

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys 
    210                 215         


<210>  69
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZTS-00008183 Heavy Chain

<400>  69
gaggtgcagc tggtggaatc tggcggcgac ctggtcaagc ctggcggcag cctgagactg       60

agctgtgtgg ccagcggctt caccttcagc aactacggca tgagctgggt ccgacaggcc      120

cctggcaagg gactgcagtg ggtggccacc atcagctacg gcggcagcta cacctactac      180

cccgacaaca tcaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccatgt actactgcgt gcggggctac      300

ggctacgaca caatggacta ctggggccag ggcaccctcg tgaccgtctc gagcgcctca      360

acaactgctc ctagcgtgtt tcccctggcc cctagctgcg gaagtacctc aggcagcaca      420

gtggccctgg cttgtctggt gtctggatat ttccctgagc cagtgaccgt gagttggaac      480

agcggctctc tgacctccgg ggtgcacaca tttccatctg tgctgcagtc tagtggcctg      540

tactccctgt caagcatggt gactgtgcct tcctctaggt ggccatcaga aactttcacc      600

tgcaacgtgg cccatcccgc cagcaagacc aaagtggaca agcccgtgcc taaaagggag      660

aatggaaggg tgccaagacc acctgattgc cctaagtgtc cagctccaga aatgctggga      720

ggaccaagcg tgttcatctt tccacccaag cccaaagaca cactgctgat tgctagaact      780

cccgaggtga cctgcgtggt ggtggacctg gatccagagg accccgaagt gcagatctcc      840

tggttcgtgg atgggaagca gatgcagaca gccaaaactc agcctcggga ggaacagttt      900

aacggaacct atagagtggt gtctgtgctg ccaattggac accaggactg gctgaagggc      960

aaacagttta catgcaaggt gaacaacaag gccctgccta gtccaatcga gaggactatt     1020

tcaaaagcta ggggacaggc tcatcagcct tccgtgtatg tgctgcctcc atcccgggag     1080

gaactgtcta agaacacagt gagtctgact tgtctgatca aagatttctt tccccctgac     1140

attgatgtgg agtggcagag caatgggcag caggagccag aatccaagta cagaaccaca     1200

ccaccccagc tggacgaaga tggctcctat ttcctgtaca gtaagctgtc agtggacaaa     1260

tctaggtggc agcgcgggga tacctttatc tgcgccgtga tgcacgaggc tctgcaccat     1320

cattacacac aagaaagtct gtcacatagc cccggcaagt agtag                     1365


<210>  70
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZTS-00008183 Heavy Chain

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His His His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  71
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  71

Ser Ser Trp Met Asn 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  72

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  73

Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr 
1               5                   10  


<210>  74
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  74

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  75
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  75

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  76

Gln His Phe Trp Gly Thr Pro Tyr Thr 
1               5                   


<210>  77
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  78
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  78
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggagcttc cgtgaaggtg       60

agctgcaaga catctggcta caccttcatc tccagctgga tgaactgggt gagacaggct      120

ccaggagctg gcctggactg gatgggccag atctaccctg gcgacggcga tacaaactat      180

aatggcaagt ttaagggaag ggtgaccctg acagctgaca ccagcacatc taccgcttac      240

atggagctgt cttccctgag ggccggcgat atcgccgtgt actattgtgc ccggcactat      300

gacggctcca ccgattactg gggccagggc acactggtga ccgtctcgag c               351


<210>  79
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  79

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys 
            100             


<210>  80
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  80
gagatcgtga tgacccagtc ccctgcttct ctgtccctga gccagggcga gaaggtgacc       60

atcacatgca gggcctctga gaacatctac tccaatctgg cttggtatca gcagcggccc      120

ggacaggctc ctaagctgct gatctacgcc gctacaaacc tggctgacgg cgtgccaagc      180

aggttctctg gatccggaag cggcaccgac ttttctctga caatctccag cctggagcca      240

gaggatgtgg ccgtgtacta ttgtcagcac ttctggggca ccccctatac atttggccag      300

ggtacc                                                                 306


<210>  81
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  81

Phe Ser Ser Tyr Gly Met His 
1               5           


<210>  82
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  82

Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr 
1               5                   10      


<210>  83
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  83

Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
1               5                   10                  


<210>  84
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  84

Arg Ala Ser Gln Gly Ile Gly Asp Asp Leu Gly 
1               5                   10      


<210>  85
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Thr Ser Thr Leu Gln Ser 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  86

Leu Gln Asp Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  87
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  88
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  88
gaagtgcagc tggtggaatc tggcggcgac ctcgtgaagc ctggcggctc tctgagactg       60

tcctgtgtgg cctccggctt caccttctcc agctacggca tgcactgggt gcgacaggcc      120

cctggaaaag gcctgcagtg ggtggccgtg atctcctacg acggctccat caagtactac      180

gccgacgccg tgaagggccg gttcaccatc agcagagaca acgccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagaaccggc      300

gagtactccg gctacgatac cgacccccag tactcttggg gccagggcac cacagtgacc      360

gtctcgagc                                                              369


<210>  89
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  89

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Asp Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys 
            100             


<210>  90
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  90
gaaattgtga tgacccagag cccggcgagc ctgagcctga gccaggaaga aaaagtgacc       60

attacctgcc gcgcgagcca gggcattggc gatgatctgg gctggtatca gcagaaaccg      120

ggccaggcgc cgaaactgct gatttatggc accagcaccc tgcagagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttagcttta ccattagcag cctggaaccg      240

gaagatgtgg cggtgtatta ttgcctgcag gatagcaact atccgctgac ctttggcgcg      300

ggcaccaaa                                                              309


<210>  91
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  91

Gly Tyr Ile Phe Ile Thr Tyr 
1               5           


<210>  92
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  92

Phe Pro Ala Ser Gly Ser 
1               5       


<210>  93
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  93

Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr 
1               5                   10          


<210>  94
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  94

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  95
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  95

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  96

Gln Gln Asn Asn Glu Asp Pro Leu Thr 
1               5                   


<210>  97
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  98
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  98
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag caagcggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggcgac      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gaca            354


<210>  99
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  99

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  100
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Mus musculus and Canis

<400>  100
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagtc tcctcaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaataacga agaccccctg      300

acctttggcc ag                                                          312


<210>  101
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  101

Ser Asn Val Ile Ser 
1               5   


<210>  102
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  102

Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  103

Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10              


<210>  104
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  104

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  105
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  106

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  107
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  107

Glu Val Gln Leu Val Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Ile Phe Ile Ser Asn 
            20                  25                  30          


Val Ile Ser Trp Val Gln Gln Ala Pro Gly Ala Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  108
<211>  359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  108
gaggtgcagc tggtgcagag cgccgctgag gtgaagaagc caggcgcctc cgtgaaggtg       60

agctgcaaga catctggcta catcttcatc tccaacgtga tcagctgggt gcagcaggct      120

ccaggagctg gactggagtg gatgggcggc gtgatcccta tcgtggacat cgccaattac      180

gctcagaggt ttaagggccg ggtgaccctg acagccgata cctctacaaa caccgtgtat      240

atggagctgt ccaatctgag gacagaggac accgccgtgt actattgtgc ttctaccctg      300

ggcctggtgc tggacgctat ggattattgg ggccagggca cactggtgac cgtctcgag       359


<210>  109
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  109

Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  110
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  110
gagaccgtgc tgacacagag ccctggcacc ctgtccctga gcccaggaga gagggccaca       60

ctgtcttgcc gggcttctca gtccctgggc tccagctacc tggcctggta tcagcagaag      120

ccaggccagg ctcccaggct gctgatctac ggagcctctt ccagagctcc aggcgtgcct      180

gctcgcttca gcggatctgg ctccggcacc gactttaccc tgacaatcag ctctctggag      240

cccgaggact tcgccgtgta ctattgtcag cagtatgctg attcccctat cacatttggc      300

cagggtacc                                                              309


<210>  111
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  111

Gly Tyr Thr Phe Ser Ser Asn Val 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  112

Val Ile Pro Ile Val Asp Ile Ala 
1               5               


<210>  113
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  113

Leu Gly Leu Val Leu Asp Ala Met Asp Tyr 
1               5                   10  


<210>  114
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  114

Arg Ala Ser Gln Ser Leu Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  115
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  115

Gly Ala Ser Ser Arg Ala Pro 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  116

Gln Gln Tyr Ala Asp Ser Pro Ile Thr 
1               5                   


<210>  117
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Ala Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Ser Ser Asn 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Tyr Val Ile Pro Ile Val Asp Ile Ala Asn Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Thr Leu Gly Leu Val Leu Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  118
<211>  359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Heavy Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  118
gaggtgcagc tggtggagag cggaggcgac ctggtgaagc cagctggctc tctgaggctg       60

tcctgcgtgg ctagcggcta caccttctcc agcaacgtga tgtcttgggt gagacaggct      120

ccaggcaagg gactgcagtg ggtgggctac gtgatcccta tcgtggacat cgccaactat      180

gccgatgctg tgaagggcag gtttaccatc tctcgggaca acgctaagaa tacactgtac      240

ctgcagatga actccctgag agtggaggat acagccgtgt actattgtac ccgcacactg      300

ggcctggtgc tggacgctat ggattattgg ggccagggca ccctggtgac agtctcgag       359


<210>  119
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  119

Glu Thr Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Pro Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Asp Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  120
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Caninized Sequence - Variable Light Region Engineered to Have 
       Sequences from Homo sapiens and Canis

<400>  120
gagaccgtgc tgacacagag ccctggcacc ctgtccctga gcccaggaga gagggccaca       60

ctgtcttgcc gggcttctca gtccctgggc tccagctacc tggcctggta tcagcagaag      120

ccaggccagg ctcccaggct gctgatctac ggagcctctt ccagagctcc aggcgtgcct      180

gctcgcttca gcggatctgg ctccggcacc gactttaccc tgacaatcag ctctctggag      240

cccgaggact tcgccgtgta ctattgtcag cagtatgctg attcccctat cacatttggc      300

cagggtacc                                                              309





