                         SEQUENCE LISTING

<110>  Nationwide Children's Hospital
 
<120>  Identification of PAX3-FOX01 Binding Genomic Regions

<130>  NCH-029706 WO ORD

<150>  US 63/084,098
<151>  2020-09-28

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Asn Ser Ile Arg His Asn Leu Ser Leu 
385                 390                 395                 400 


His Ser Lys Phe Ile Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser 
                405                 410                 415     


Trp Trp Met Leu Asn Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg 
            420                 425                 430         


Arg Arg Ala Ala Ser Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg 
        435                 440                 445             


Ser Arg Ala Ala Lys Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly 
    450                 455                 460                 


Ala Gly Asp Ser Pro Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro 
465                 470                 475                 480 


Gly Ser His Ser Asn Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro 
                485                 490                 495     


Arg Thr Ser Ser Asn Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile 
            500                 505                 510         


Met Thr Glu Gln Asp Asp Leu Gly Glu Gly Asp Val His Ser Met Val 
        515                 520                 525             


Tyr Pro Pro Ser Ala Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser 
    530                 535                 540                 


Glu Ile Ser Asn Pro Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn 
545                 550                 555                 560 


Leu Leu Ser Ser Pro Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro 
                565                 570                 575     


Gly Thr Met Met Gln Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn 
            580                 585                 590         


Thr Ser Leu Asn Ser Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly 
        595                 600                 605             


Gln Ser Ser Met Ser Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln 
    610                 615                 620                 


Asp Asn Lys Ser Ser Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro 
625                 630                 635                 640 


Gly Leu Leu Lys Glu Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp 
                645                 650                 655     


Ile Met Thr Pro Val Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val 
            660                 665                 670         


Leu Gly Gln Asn Val Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr 
        675                 680                 685             


Gly Ser Gln Ala Ser His Asn Lys Met Met Asn Pro Ser Ser His Thr 
    690                 695                 700                 


His Pro Gly His Ala Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu 
705                 710                 715                 720 


Pro His Thr Val Ser Thr Met Pro His Thr Ser Gly Met Asn Arg Leu 
                725                 730                 735     


Thr Gln Val Lys Thr Pro Val Gln Val Pro Leu Pro His Pro Met Gln 
            740                 745                 750         


Met Ser Ala Leu Gly Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr 
        755                 760                 765             


Gly Arg Met Gly Leu Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp 
    770                 775                 780                 


Gly Met Phe Ile Glu Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg 
785                 790                 795                 800 


Asn Asp Leu Met Asp Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val 
                805                 810                 815     


Leu Pro Asn Gln Ser Phe Pro His Ser Val Lys Thr Thr Thr His Ser 
            820                 825                 830         


Trp Val Ser Gly 
        835     


<210>  2
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Leu Pro Gly Thr Val Pro Arg Met Met Arg Pro Ala Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Thr Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Arg Gln Val Ala Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Arg Leu Leu Lys Asp Gly His Cys Asp 
    130                 135                 140                 


Arg Ser Thr Val Pro Ser Gly Leu Val Ser Ser Ile Ser Arg Val Leu 
145                 150                 155                 160 


Arg Ile Lys Phe Gly Lys Lys Glu Glu Glu Asp Glu Ala Asp Lys Lys 
                165                 170                 175     


Glu Asp Asp Gly Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Gly Asp Lys Gly Asn Arg Leu Asp Glu Gly Ser Asp Val Glu Ser Glu 
        195                 200                 205             


Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr Phe 
    210                 215                 220                 


Thr Ala Glu Gln Leu Glu Glu Leu Glu Lys Ala Phe Glu Arg Thr His 
225                 230                 235                 240 


Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Thr Lys Leu 
                245                 250                 255     


Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg Trp 
            260                 265                 270         


Arg Lys Gln Ala Gly Ala Asn Gln Leu Ala Ala Phe Asn His Leu Leu 
        275                 280                 285             


Pro Gly Gly Phe Pro Pro Thr Gly Met Pro Thr Leu Pro Pro Tyr Gln 
    290                 295                 300                 


Leu Pro Asp Ser Thr Tyr Pro Thr Thr Thr Ile Ser Gln Asp Gly Gly 
305                 310                 315                 320 


Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro Ser Thr Met His Gln 
                325                 330                 335     


Gly Gly Leu Ala Ala Ala Ala Ala Ala Ala Asp Thr Ser Ser Ala Tyr 
            340                 345                 350         


Gly Ala Arg His Ser Phe Ser Ser Tyr Ser Asp Ser Phe Met Asn Pro 
        355                 360                 365             


Ala Ala Pro Ser Asn His Met Asn Pro Val Ser Asn Gly Leu Ser Asn 
    370                 375                 380                 


Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Arg Val Gln 
385                 390                 395                 400 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu Gly 
                405                 410                 415     


Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser Met Asp Asn 
            420                 425                 430         


Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys Lys Lys Ala 
        435                 440                 445             


Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro Gly Ser Gln 
    450                 455                 460                 


Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn Asp Asp Phe 
465                 470                 475                 480 


Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn Ala Ser Thr 
                485                 490                 495     


Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp Asp Leu Gly 
            500                 505                 510         


Glu Gly Asp Val His Ser Met Val Tyr Pro Pro Ser Ala Ala Lys Met 
        515                 520                 525             


Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro Glu Asn Met 
    530                 535                 540                 


Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro Thr Ser Leu 
545                 550                 555                 560 


Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln Gln Thr Pro 
                565                 570                 575     


Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser Pro Ser Pro 
            580                 585                 590         


Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser Pro Leu Pro 
        595                 600                 605             


Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser Tyr Gly Gly 
    610                 615                 620                 


Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu Leu Leu Thr 
625                 630                 635                 640 


Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val Asp Pro Gly 
                645                 650                 655     


Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val Met Met Gly 
            660                 665                 670         


Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser His Asn Lys 
        675                 680                 685             


Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala Gln Gln Thr 
    690                 695                 700                 


Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser Thr Met Pro 
705                 710                 715                 720 


His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr Pro Val Gln 
                725                 730                 735     


Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly Gly Tyr Ser 
            740                 745                 750         


Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu Leu His Gln 
        755                 760                 765             


Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu Arg Leu Asp 
    770                 775                 780                 


Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp Gly Asp Thr 
785                 790                 795                 800 


Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser Phe Pro His 
                805                 810                 815     


Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
            820                 825             


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for the hg38 region of PAX3-FOXO1

<400>  3
cagaaccatc ccattctccg                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  4
gcctgacctt gaacgtgaat                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  5
ggatcgtgta acctgagggc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  6
cagtgagtgt ctgcctgcaa                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  7
tgcatgctgg tgacagatca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  8
acagcgtcct ctttcagctt                                                   20


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  9
ttcccatgaa aggagaagca ga                                                22


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  10
ggaaatgcct ccacagaaac g                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  11
aaatttgacc ttcgtcggca c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  12
cagctgttgg cgatttcacg                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  13
gctcttggtt ctctgtccct                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for hg38 region of PAX3-FOXO1

<400>  14
agacagactg tgatgtgggg                                                   20


