                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Beachy, Philip A.
       Zhang, Yunxiao
       Manglik, Aashish
 
<120>  POTENT BINDING AGENTS FOR ACTIVATION OF THE HEDGEHOG SIGNALING 
       PATHWAY

<130>  STAN-1688WO

<150>  US 63/083,544
<151>  2020-09-25

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Leu Ser His 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Phe Gly Thr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Phe Thr Pro Ile Phe His His Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  2
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Leu Pro Tyr 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Asp Gln Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Ala Tyr Thr Pro Glu Val Tyr His Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  3
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Asp Thr Gly 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Gly Gly Gly Thr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Arg Asn Tyr Gly Ile Phe Tyr Val Ser Lys Tyr Ser Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Asp Asp Gly 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ala Tyr Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Tyr Phe Pro Asp Asn Pro Pro Tyr Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  5
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Asp Gly Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Gly Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Leu Tyr Thr Pro Val Phe Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  6
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Trp Tyr Val 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asp His Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Lys Gly Tyr Arg Tyr Gly Phe Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  7
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Tyr Leu Tyr 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Glu Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Ile Asn Val Leu Gly His His Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  8
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Leu Trp Glu 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Thr Gly Ser Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Arg Val Ile Ser Trp Tyr Asn Phe Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  9
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Gln Ala Gly 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Gly His Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Trp Trp Asp Leu Arg His Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Tyr Arg Tyr His Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  11
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Thr Ala Thr 
            20                  25                  30          


Gln Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ala Tyr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Pro Asp Tyr Tyr His Tyr His Val Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  12
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Thr Ile Gln 
            20                  25                  30          


Gln Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Phe Gly Thr Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gln Trp Thr Ile Trp Asp Ala His Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  13
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Ala Asp Gln 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Val Gly Ala Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gly Ile Thr Ile Asn Gly Val Ile Tyr Val Pro His Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Leu Ser His 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Phe Gly Thr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Phe Thr Pro Ile Phe His His Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  15
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Leu Pro Tyr 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Asp Gln Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Ala Tyr Thr Pro Glu Val Tyr His Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  16
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Asp Thr Gly 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Gly Gly Gly Thr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Arg Asn Tyr Gly Ile Phe Tyr Val Ser Lys Tyr Ser Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Asp Gly Asn 
            20                  25                  30          


Leu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Gly Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Trp Leu Tyr Thr Pro Val Phe Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  18
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Tyr Arg Tyr His Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  19
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Asp Ile Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys Val 
                85                  90                  95      


Val Gln Ala Val Pro Tyr Arg Tyr Arg Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  20
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Gly Ala 
                85                  90                  95      


Val Gln Ala Val Pro Tyr Arg Tyr His Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  21
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Asn Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Tyr Arg Tyr His Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  22
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Asn Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Ile Gly Ser Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Asn Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Tyr Arg Tyr Arg Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  23
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Ile Arg Tyr Arg Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  24
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (50)..(50)
<223>  The amino acid at position 50 is Gly, Ala, Ser, Thr or Asp

<220>
<221>  SITE
<222>  (77)..(77)
<223>  The amino acid at position 77 is Thr or Asn

<220>
<221>  SITE
<222>  (102)..(102)
<223>  The amino acid at position 102 is Tyr or Ile

<220>
<221>  SITE
<222>  (105)..(105)
<223>  The amino acid at position 105 is His or Arg

<220>
<221>  SITE
<222>  (106)..(106)
<223>  The amino acid at position 106 is Gly or Arg

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Xaa Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Xaa Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Xaa Arg Tyr Xaa Xaa Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  25
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Ile Arg Tyr Arg Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
        115                 120                 125             


Ser Gly Leu Arg Glu Leu His Leu Asn Asn Asn 
    130                 135                 


<210>  26
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Leu Arg Glu Leu His Leu Asn Asn Asn 
1               5                   


<210>  27
<211>  408
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ala Tyr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asp Ile Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Gln Ala Val Pro Ile Arg Tyr Arg Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Ser Gln Phe Arg Val Ser Pro Leu Asp 
        115                 120                 125             


Arg Thr Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu 
    130                 135                 140                 


Leu Ser Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly 
145                 150                 155                 160 


Ala Ala Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro 
                165                 170                 175     


Lys Ala Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu 
            180                 185                 190         


Gly Asp Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu 
        195                 200                 205             


Gly Tyr Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser 
    210                 215                 220                 


His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
225                 230                 235                 240 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
                245                 250                 255     


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
            260                 265                 270         


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
        275                 280                 285             


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
    290                 295                 300                 


Leu Ser Tyr Arg Phe Lys Gln Gly Phe Arg Arg Ile Leu Leu Arg Pro 
305                 310                 315                 320 


Ser Arg Arg Ile Arg Ser Gln Glu Pro Gly Ser Gly Pro Pro Glu Lys 
                325                 330                 335     


Thr Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Arg Arg Glu Glu Glu 
            340                 345                 350         


Glu Arg Arg Met Gln Arg Gly Gln Glu Met Asn Gly Arg Leu Ser Gln 
        355                 360                 365             


Ile Ala Gln Ala Gly Thr Ser Gly Gln Gln Pro Arg Pro Cys Thr Gly 
    370                 375                 380                 


Thr Ala Lys Glu Gln Gln Leu Leu Pro Gln Glu Ala Thr Ala Gly Asp 
385                 390                 395                 400 


Lys Ala Ser Thr Leu Ser His Leu 
                405             


<210>  28
<211>  185
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                165                 170                 175     


Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            180                 185 


<210>  29
<211>  104
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Leu Ser Tyr Arg Phe Lys Gln Gly Phe Arg Arg Ile Leu Leu Arg Pro 
1               5                   10                  15      


Ser Arg Arg Ile Arg Ser Gln Glu Pro Gly Ser Gly Pro Pro Glu Lys 
            20                  25                  30          


Thr Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Arg Arg Glu Glu Glu 
        35                  40                  45              


Glu Arg Arg Met Gln Arg Gly Gln Glu Met Asn Gly Arg Leu Ser Gln 
    50                  55                  60                  


Ile Ala Gln Ala Gly Thr Ser Gly Gln Gln Pro Arg Pro Cys Thr Gly 
65                  70                  75                  80  


Thr Ala Lys Glu Gln Gln Leu Leu Pro Gln Glu Ala Thr Ala Gly Asp 
                85                  90                  95      


Lys Ala Ser Thr Leu Ser His Leu 
            100                 


<210>  30
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Cys Gln Asp Ser Glu Thr Arg Thr Phe Tyr 
1               5                   10  


<210>  31
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Thr Ala Leu Ile Ile Leu Val Gly Ile Gly Ala Asp Asp Ala Phe Val 
1               5                   10                  15      


Leu Cys Asp Val Trp 
            20      


<210>  32
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Phe Gly Met Val Leu Ala Ile Gly Leu Leu Val Asp Asp Ala Ile Val 
1               5                   10                  15      


Val Val Glu Asn Val 
            20      


<210>  33
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Val Leu Pro Phe Leu Ala Leu Gly Val Gly Val Asp Asp Val Gly Leu 
1               5                   10                  15      


Leu Ala His Ala Phe 
            20      


<210>  34
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
1               5                   10                  15      


Leu Val Gln Thr Tyr 
            20      


<210>  35
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Val Gly Leu Leu Thr Thr Ile Gly Leu Ser Ala Lys Asn Ala Ile Leu 
1               5                   10                  15      


Ile Val Glu Phe 
            20  


<210>  36
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Val Thr Ile Ser Val Ala Val Gly Leu Ser Val Asp Phe Ala Val His 
1               5                   10                  15      


Tyr Gly Val Ala Tyr 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Val Ile Leu Ile Ala Ser Val Gly Ile Gly Val Glu Phe Thr Val His 
1               5                   10                  15      


Val Ala Leu Ala Phe 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Val Asn Leu Val Met Ser Cys Gly Ile Ser Val Glu Phe Cys Ser His 
1               5                   10                  15      


Ile Thr Arg Ala Phe 
            20      


