                         SEQUENCE LISTING

<110>  EpiVax, Inc.
 
<120>  RETRO-INVERSO REGULATORY T CELL EPITOPES

<130>  EPV 0022_PCT

<140>  PCT/US2021/052017
<141>  2021-09-24

<150>  US 63/083,392
<151>  2020-09-25

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  1

His Lys Ser Pro Val Thr Val Val Ser Ser Leu Ser Tyr Leu Gly Ser 
1               5                   10                  15      


Ser Gln Leu Val Ala Lys 
            20          


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  2

His Lys Ser Pro Val Thr Val Val Ser 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  3

Lys Ser Pro Val Thr Val Val Ser Ser 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  4

Ser Pro Val Thr Val Val Ser Ser Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  5

Pro Val Thr Val Val Ser Ser Leu Ser 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  6

Val Thr Val Val Ser Ser Leu Ser Tyr 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  7

Thr Val Val Ser Ser Leu Ser Tyr Leu 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  8

Val Val Ser Ser Leu Ser Tyr Leu Gly 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  9

Val Ser Ser Leu Ser Tyr Leu Gly Ser 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  10

Ser Ser Leu Ser Tyr Leu Gly Ser Ser 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  11

Ser Leu Ser Tyr Leu Gly Ser Ser Gln 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  12

Leu Ser Tyr Leu Gly Ser Ser Gln Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  13

Ser Tyr Leu Gly Ser Ser Gln Leu Val 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  14

Tyr Leu Gly Ser Ser Gln Leu Val Ala 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  15

Leu Gly Ser Ser Gln Leu Val Ala Lys 
1               5                   


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  16

Asp Gln His Leu Val Thr Leu Val Ser Val Val Thr Tyr Thr Ser Asn 
1               5                   10                  15      


Tyr Gln Glu Glu 
            20  


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  17

Asp Gln His Leu Val Thr Leu Val Ser 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  18

Gln His Leu Val Thr Leu Val Ser Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  19

His Leu Val Thr Leu Val Ser Val Val 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  20

Leu Val Thr Leu Val Ser Val Val Thr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  21

Val Thr Leu Val Ser Val Val Thr Tyr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  22

Thr Leu Val Ser Val Val Thr Tyr Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  23

Leu Val Ser Val Val Thr Tyr Thr Ser 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  24

Val Ser Val Val Thr Tyr Thr Ser Asn 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  25

Ser Val Val Thr Tyr Thr Ser Asn Tyr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  26

Ser Val Val Thr Tyr Thr Ser Asn Tyr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  27

Val Val Thr Tyr Thr Ser Asn Tyr Gln 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  28

Val Thr Tyr Thr Ser Asn Tyr Gln Glu 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<223>  A retro-inverso Tregitope peptide

<400>  29

Thr Tyr Thr Ser Asn Tyr Gln Glu Glu 
1               5                   


<210>  30
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr 
1               5                   10                  15      


Ala Phe Ile Glu Tyr 
            20      


<210>  31
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  31

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Leu Ser Ser 
1               5                   10                  15      


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            20                  25              


<210>  32
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  32
gttaactagt tcagctggac cacagccgca gc                                     32


<210>  33
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  33
cgggttaact agttcagaaa tcctttctct tgaccatggc                             40


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  34
ctagcctctg gaatcctttc tcttg                                             25


<210>  35
<211>  9
<212>  PRT
<213>  Human Influenza A virus

<400>  35

Pro Arg Tyr Val Lys Gln Asn Thr Leu 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Human Influenza A virus

<400>  36

Arg Tyr Val Lys Gln Asn Thr Leu Lys 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Human Influenza A virus

<400>  37

Tyr Val Lys Gln Asn Thr Leu Lys Leu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Human Influenza A virus

<400>  38

Val Lys Gln Asn Thr Leu Lys Leu Ala 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Human Influenza A virus

<400>  39

Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   


<210>  40
<211>  2373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Thr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Cys Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser Glu Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser Asn Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Ser Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Phe Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr His Lys Ser Pro  Val Thr Val 
    2345                 2350                 2355             


Val Ser  Ser Leu Ser Tyr Leu  Gly Ser Ser Gln Leu  Val Ala Lys 
    2360                 2365                 2370             


<210>  41
<211>  2372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

His Lys Ser Pro Val Thr Val Val Ser Ser Leu Ser Tyr Leu Gly Ser 
1               5                   10                  15      


Ser Gln Leu Val Ala Lys Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu 
            20                  25                  30          


Cys Leu Leu Arg Phe Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly 
        35                  40                  45              


Ala Val Glu Leu Ser Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu 
    50                  55                  60                  


Pro Val Asp Ala Arg Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe 
65                  70                  75                  80  


Asn Thr Ser Val Val Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp 
                85                  90                  95      


His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu 
            100                 105                 110         


Gly Pro Thr Ile Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu 
        115                 120                 125             


Lys Asn Met Ala Ser His Pro Val Ser Leu His Ala Val Gly Val Ser 
    130                 135                 140                 


Tyr Trp Lys Ala Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln 
145                 150                 155                 160 


Arg Glu Lys Glu Asp Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr 
                165                 170                 175     


Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu 
            180                 185                 190         


Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu 
        195                 200                 205             


Asn Ser Gly Leu Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu 
    210                 215                 220                 


Ala Lys Glu Lys Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala 
225                 230                 235                 240 


Val Phe Asp Glu Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu 
                245                 250                 255     


Met Gln Asp Arg Asp Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His 
            260                 265                 270         


Thr Val Asn Gly Thr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys 
        275                 280                 285             


His Arg Lys Ser Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro 
    290                 295                 300                 


Glu Val His Ser Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn 
305                 310                 315                 320 


His Arg Gln Ala Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala 
                325                 330                 335     


Gln Thr Leu Leu Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile 
            340                 345                 350         


Ser Ser His Gln His Asp Gly Met Glu Ala Tyr Val Lys Cys Asp Ser 
        355                 360                 365             


Cys Pro Glu Glu Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu 
    370                 375                 380                 


Asp Tyr Asp Asp Asp Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe 
385                 390                 395                 400 


Asp Asp Asp Asn Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys 
                405                 410                 415     


Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp 
            420                 425                 430         


Trp Asp Tyr Ala Pro Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys 
        435                 440                 445             


Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys 
    450                 455                 460                 


Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu 
465                 470                 475                 480 


Ala Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu 
                485                 490                 495     


Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro 
            500                 505                 510         


Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser 
        515                 520                 525             


Arg Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu 
    530                 535                 540                 


Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly 
545                 550                 555                 560 


Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe 
                565                 570                 575     


Val Asn Met Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu 
            580                 585                 590         


Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser 
        595                 600                 605             


Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser 
    610                 615                 620                 


Trp Tyr Leu Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly 
625                 630                 635                 640 


Val Gln Leu Glu Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser 
                645                 650                 655     


Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His 
            660                 665                 670         


Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe 
        675                 680                 685             


Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr 
    690                 695                 700                 


Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met 
705                 710                 715                 720 


Ser Met Glu Asn Pro Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp 
                725                 730                 735     


Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp 
            740                 745                 750         


Lys Asn Thr Gly Asp Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala 
        755                 760                 765             


Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln 
    770                 775                 780                 


Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr 
785                 790                 795                 800 


Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg 
                805                 810                 815     


Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met 
            820                 825                 830         


Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu 
        835                 840                 845             


Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala 
    850                 855                 860                 


Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln 
865                 870                 875                 880 


Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln 
                885                 890                 895     


Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys 
            900                 905                 910         


Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr 
        915                 920                 925             


Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu 
    930                 935                 940                 


Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr 
945                 950                 955                 960 


Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu 
                965                 970                 975     


Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu 
            980                 985                 990         


Met Asn Ser Gln Glu Ser Ser Trp  Gly Lys Asn Val Ser  Ser Thr Glu 
        995                 1000                 1005             


Ser Gly  Arg Leu Phe Lys Gly  Lys Arg Ala His Gly  Pro Ala Leu 
    1010                 1015                 1020             


Leu Thr  Lys Asp Asn Ala Leu  Phe Lys Val Ser Ile  Ser Leu Leu 
    1025                 1030                 1035             


Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala Thr Asn  Arg Lys Thr 
    1040                 1045                 1050             


His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu Asn Ser  Pro Ser Val 
    1055                 1060                 1065             


Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu Phe Lys  Lys Val Thr 
    1070                 1075                 1080             


Pro Leu  Ile His Asp Arg Met  Leu Met Asp Lys Asn  Ala Thr Ala 
    1085                 1090                 1095             


Leu Arg  Leu Asn His Met Ser  Asn Lys Thr Thr Ser  Ser Lys Asn 
    1100                 1105                 1110             


Met Glu  Met Val Gln Gln Lys  Lys Glu Gly Pro Ile  Pro Pro Asp 
    1115                 1120                 1125             


Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys Met Leu  Phe Leu Pro 
    1130                 1135                 1140             


Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His Gly Lys  Asn Ser Leu 
    1145                 1150                 1155             


Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln Leu Val  Ser Leu Gly 
    1160                 1165                 1170             


Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe Leu Ser  Glu Lys Asn 
    1175                 1180                 1185             


Lys Val  Val Val Gly Lys Gly  Glu Phe Thr Lys Asp  Val Gly Leu 
    1190                 1195                 1200             


Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn Leu Phe  Leu Thr Asn 
    1205                 1210                 1215             


Leu Asp  Asn Leu His Glu Asn  Asn Thr His Asn Gln  Glu Lys Lys 
    1220                 1225                 1230             


Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr Leu Ile  Gln Glu Asn 
    1235                 1240                 1245             


Val Val  Leu Pro Gln Ile His  Thr Val Thr Gly Thr  Lys Asn Phe 
    1250                 1255                 1260             


Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg Gln Asn  Val Glu Gly 
    1265                 1270                 1275             


Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu Gln Asp  Phe Arg Ser 
    1280                 1285                 1290             


Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys His Thr  Ala His Phe 
    1295                 1300                 1305             


Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu Gly Leu  Gly Asn Gln 
    1310                 1315                 1320             


Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys Thr Thr  Arg Ile Ser 
    1325                 1330                 1335             


Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr Gln Arg  Ser Lys Arg 
    1340                 1345                 1350             


Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu Glu Thr  Glu Leu Glu 
    1355                 1360                 1365             


Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr Gln Trp  Ser Lys Asn 
    1370                 1375                 1380             


Met Lys  His Leu Thr Pro Ser  Thr Leu Thr Gln Ile  Asp Tyr Asn 
    1385                 1390                 1395             


Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser Pro Leu  Ser Asp Cys 
    1400                 1405                 1410             


Leu Thr  Arg Ser Glu Ser Ile  Pro Gln Ala Asn Arg  Ser Pro Leu 
    1415                 1420                 1425             


Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser Ile Arg  Pro Ile Tyr 
    1430                 1435                 1440             


Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser Ser Asn  Leu Pro Ala 
    1445                 1450                 1455             


Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val Gln Glu  Ser Ser His 
    1460                 1465                 1470             


Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu Ser Leu  Ala Ile Leu 
    1475                 1480                 1485             


Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu Val Gly  Ser Leu Gly 
    1490                 1495                 1500             


Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys Lys Val  Glu Asn Thr 
    1505                 1510                 1515             


Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr Ser Gly  Lys Val Glu 
    1520                 1525                 1530             


Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys Asp Leu  Phe Pro Thr 
    1535                 1540                 1545             


Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu Asp Leu  Val Glu Gly 
    1550                 1555                 1560             


Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile Lys Trp  Asn Glu Ala 
    1565                 1570                 1575             


Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg Val Ala  Thr Glu Ser 
    1580                 1585                 1590             


Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp Pro Leu  Ala Trp Asp 
    1595                 1600                 1605             


Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu Glu Trp  Lys Ser Gln 
    1610                 1615                 1620             


Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys Lys Lys  Asp Thr Ile 
    1625                 1630                 1635             


Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His Ala Ile  Ala Ala Ile 
    1640                 1645                 1650             


Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu Val Thr  Trp Ala Lys 
    1655                 1660                 1665             


Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln Asn Pro  Pro Val Leu 
    1670                 1675                 1680             


Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr Thr Leu  Gln Ser Asp 
    1685                 1690                 1695             


Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile Ser Val  Glu Met Lys 
    1700                 1705                 1710             


Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp Glu Asn  Gln Ser Pro 
    1715                 1720                 1725             


Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr Phe Ile  Ala Ala Val 
    1730                 1735                 1740             


Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser Ser Pro  His Val Leu 
    1745                 1750                 1755             


Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 
    1760                 1765                 1770             


Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 
    1775                 1780                 1785             


Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 
    1790                 1795                 1800             


Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Arg Asn Gln 
    1805                 1810                 1815             


Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 
    1820                 1825                 1830             


Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Asn  Phe Val Lys 
    1835                 1840                 1845             


Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys Val Gln  His His Met 
    1850                 1855                 1860             


Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 
    1865                 1870                 1875             


Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 
    1880                 1885                 1890             


Pro Leu  Leu Val Cys His Thr  Asn Thr Leu Asn Pro  Ala His Gly 
    1895                 1900                 1905             


Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
    1910                 1915                 1920             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1925                 1930                 1935             


Cys Arg  Ala Pro Ser Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1940                 1945                 1950             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1955                 1960                 1965             


Leu Phe  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1970                 1975                 1980             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1985                 1990                 1995             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    2000                 2005                 2010             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    2015                 2020                 2025             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    2030                 2035                 2040             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    2045                 2050                 2055             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    2060                 2065                 2070             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    2075                 2080                 2085             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    2090                 2095                 2100             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    2105                 2110                 2115             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    2120                 2125                 2130             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    2135                 2140                 2145             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    2150                 2155                 2160             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    2165                 2170                 2175             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    2180                 2185                 2190             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    2195                 2200                 2205             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    2210                 2215                 2220             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    2225                 2230                 2235             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    2240                 2245                 2250             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    2255                 2260                 2265             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    2270                 2275                 2280             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    2285                 2290                 2295             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    2300                 2305                 2310             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    2315                 2320                 2325             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    2330                 2335                 2340             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    2345                 2350                 2355             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    2360                 2365                 2370         


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Phe Thr Phe Gly Ser Ala Ala Cys Ser Leu Arg Leu Ser Gly Gly Pro 
1               5                   10                  15      


Gln Val Leu Gly Gly 
            20      


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Phe Thr Phe Gly Ser Ala Ala Cys Ser 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Thr Phe Gly Ser Ala Ala Cys Ser Leu 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Phe Gly Ser Ala Ala Cys Ser Leu Arg 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gly Ser Ala Ala Cys Ser Leu Arg Leu 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Ser Ala Ala Cys Ser Leu Arg Leu Ser 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Ala Ala Cys Ser Leu Arg Leu Ser Gly 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Ala Cys Ser Leu Arg Leu Ser Gly Gly 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Cys Ser Leu Arg Leu Ser Gly Gly Pro 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Ser Leu Arg Leu Ser Gly Gly Pro Gln 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Leu Arg Leu Ser Gly Gly Pro Gln Val 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Arg Leu Ser Gly Gly Pro Gln Val Leu 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54

Leu Ser Gly Gly Pro Gln Val Leu Gly 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Ser Gly Gly Pro Gln Val Leu Gly Gly 
1               5                   


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Val Trp Glu Leu Gly Lys Gly Pro Ala Gln Arg Val Trp His Met 
1               5                   10                  15  


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Val Trp Glu Leu Gly Lys Gly Pro Ala 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Trp Glu Leu Gly Lys Gly Pro Ala Gln 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Glu Leu Gly Lys Gly Pro Ala Gln Arg 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Leu Gly Lys Gly Pro Ala Gln Arg Val 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Gly Lys Gly Pro Ala Gln Arg Val Trp 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Lys Gly Pro Ala Gln Arg Val Trp His 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Gly Pro Ala Gln Arg Val Trp His Met 
1               5                   


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Asp Glu Pro Gln Leu Ser Ser Ile Thr Leu Thr Phe Asp Thr Gly 
1               5                   10                  15  


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Asp Glu Pro Gln Leu Ser Ser Ile Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Glu Pro Gln Leu Ser Ser Ile Thr Leu 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Pro Gln Leu Ser Ser Ile Thr Leu Thr 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Gln Leu Ser Ser Ile Thr Leu Thr Phe 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Leu Ser Ser Ile Thr Leu Thr Phe Asp 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Ser Ser Ile Thr Leu Thr Phe Asp Thr 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Ser Ile Thr Leu Thr Phe Asp Thr Gly 
1               5                   


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

His Lys Ala Thr Asp Glu Ala Arg Leu Ser Asn Met Gln Leu Tyr Leu 
1               5                   10                  15      


Thr Lys 
        


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

His Lys Ala Thr Asp Glu Ala Arg Leu 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Lys Ala Thr Asp Glu Ala Arg Leu Ser 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75

Ala Thr Asp Glu Ala Arg Leu Ser Asn 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Thr Asp Glu Ala Arg Leu Ser Asn Met 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77

Asp Glu Ala Arg Leu Ser Asn Met Gln 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Glu Ala Arg Leu Ser Asn Met Gln Leu 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79

Ala Arg Leu Ser Asn Met Gln Leu Tyr 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Arg Leu Ser Asn Met Gln Leu Tyr Leu 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81

Leu Ser Asn Met Gln Leu Tyr Leu Thr 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Ser Asn Met Gln Leu Tyr Leu Thr Lys 
1               5                   


<210>  83
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83

Ser Asn Gly Ser Gln Leu Ala Asn Asp Val Lys Trp Gln Val Lys Ala 
1               5                   10                  15      


Glu Arg Pro Tyr Phe Asn Asn Leu 
            20                  


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Ser Asn Gly Ser Gln Leu Ala Asn Asp 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85

Asn Gly Ser Gln Leu Ala Asn Asp Val 
1               5                   


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Gly Ser Gln Leu Ala Asn Asp Val Lys 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87

Ser Gln Leu Ala Asn Asp Val Lys Trp 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Gln Leu Ala Asn Asp Val Lys Trp Gln 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89

Leu Ala Asn Asp Val Lys Trp Gln Val 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Ala Asn Asp Val Lys Trp Gln Val Lys 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91

Asn Asp Val Lys Trp Gln Val Lys Ala 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92

Asp Val Lys Trp Gln Val Lys Ala Glu 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93

Val Lys Trp Gln Val Lys Ala Glu Arg 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94

Lys Trp Gln Val Lys Ala Glu Arg Pro 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95

Trp Gln Val Lys Ala Glu Arg Pro Tyr 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96

Gln Val Lys Ala Glu Arg Pro Tyr Phe 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97

Val Lys Ala Glu Arg Pro Tyr Phe Asn 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98

Lys Ala Glu Arg Pro Tyr Phe Asn Asn 
1               5                   


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99

Ala Glu Arg Pro Tyr Phe Asn Asn Leu 
1               5                   


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Lys Gly Tyr Ile Phe Ser His Gly Thr Phe His Ile Thr Leu Ile 
1               5                   10                  15  


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101

Lys Gly Tyr Ile Phe Ser His Gly Thr 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102

Gly Tyr Ile Phe Ser His Gly Thr Phe 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103

Tyr Ile Phe Ser His Gly Thr Phe His 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  104

Ile Phe Ser His Gly Thr Phe His Ile 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  105

Phe Ser His Gly Thr Phe His Ile Thr 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106

Ser His Gly Thr Phe His Ile Thr Leu 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107

His Gly Thr Phe His Ile Thr Leu Ile 
1               5                   


<210>  108
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  108

Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
1               5                   10                  15      


Ser Gly Phe Thr Phe 
            20      


<210>  109
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  109

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15  


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110

Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
1               5                   10                  15  


<210>  111
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111

Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
1               5                   10                  15      


Lys His 
        


<210>  112
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  112

Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
1               5                   10                  15      


Asn Ala Leu Gln Ser Gly Asn Ser 
            20                  


<210>  113
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113

Lys Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
1               5                   10                  15      


Thr Val Pro Ser Lys His 
            20          


<210>  114
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  114

Glu Glu Gln Tyr Asn Ser Thr Tyr Thr Val Val Ser Val Leu Thr Val 
1               5                   10                  15      


Leu His Gln Asp 
            20  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  115

Ile Leu Thr Ile His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys 
1               5                   10                  15  


