                         SEQUENCE LISTING

<110>  Miraki Innovation Think Tank LLC
       VARMA, Nisha Veronica
       CRAWFORD, Keith
       MARTIN, Gregory T.
       BOER, Goossen Jan Bernard
       GUPTA, Rainuka
       ZHOU, Zhiqian
       VELIS, Christopher
       CONNERTY, Andrew  D.
 
<120>  COMPOSITIONS, DEVICES AND METHODS COMPRISING MICROBE-TARGETING 
       MOLECULES FOR DIAGNOSING AND TREATING INFECTIOUS DISEASE

<130>  2021-1712A

<150>  US 63/083,465
<151>  2020-09-25

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210>  2
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile 
1               5                   10                  15      


Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg 
            20                  25                  30          


Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly 
        35                  40                  45              


Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro 
    50                  55                  60                  


Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser 
65                  70                  75                  80  


Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
                85                  90                  95      


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys 
            100                 105                 110         


Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe 
        115                 120                 125             


Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr 
    130                 135                 140                 


Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu 
145                 150                 155                 160 


Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val 
                165                 170                 175     


Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu 
            180                 185                 190         


Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn 
        195                 200                 205             


Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys 
    210                 215                 220                 


Glu Phe Pro Ile 
225             


<210>  3
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys 
1               5                   10                  15      


Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe 
            20                  25                  30          


Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys 
        35                  40                  45              


Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn 
    50                  55                  60                  


Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr 
65                  70                  75                  80  


Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu 
                85                  90                  95      


Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp 
            100                 105                 110         


Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro 
        115                 120                 125             


Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    130                 135                 140     


<210>  4
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu 
1               5                   10                  15      


Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro 
            20                  25                  30          


Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu 
        35                  40                  45              


Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp 
    50                  55                  60                  


Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro 
65                  70                  75                  80  


Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly 
                85                  90                  95      


Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu 
            100                 105                 110         


Phe Pro Ile 
        115 


<210>  5
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  5

Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
1               5                   10                  15      


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys 
            20                  25                  30          


Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe 
        35                  40                  45              


Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr 
    50                  55                  60                  


Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu 
65                  70                  75                  80  


Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val 
                85                  90                  95      


Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu 
            100                 105                 110         


Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn 
        115                 120                 125             


Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys 
    130                 135                 140                 


Glu Phe Pro Ile 
145             


<210>  6
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly-produced fusion protein

<400>  6

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser Ser Leu Ala 
225                 230                 235                 240 


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
                245                 250                 255     


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
            260                 265                 270         


Thr Asn Gly Glu Ile Asn Ile Thr Phe Glu Lys Val Lys Ala Leu Cys 
        275                 280                 285             


Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn 
    290                 295                 300                 


Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr 
305                 310                 315                 320 


Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu 
                325                 330                 335     


Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp 
            340                 345                 350         


Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro 
        355                 360                 365             


Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    370                 375                 380     


<210>  7
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly-produced fusion protein

<400>  7

Ala Lys Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser 
225                 230                 235                 240 


Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg 
                245                 250                 255     


Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys 
            260                 265                 270         


Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala 
        275                 280                 285             


Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala 
    290                 295                 300                 


Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly 
305                 310                 315                 320 


Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn 
                325                 330                 335     


Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly 
            340                 345                 350         


Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp 
        355                 360                 365             


Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    370                 375                 380             


<210>  8
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly-produced fusion protein

<400>  8

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala Thr Ser Lys Gln Val Gly Asn Lys 
225                 230                 235                 240 


Phe Phe Leu Thr Asn Gly Glu Glu Val Ile Thr Phe Glu Lys Val Lys 
                245                 250                 255     


Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala 
            260                 265                 270         


Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu 
        275                 280                 285             


Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly 
    290                 295                 300                 


Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala 
305                 310                 315                 320 


Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn 
                325                 330                 335     


Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
            340                 345                 350         


<210>  9
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinantly-produced fusion protein

<400>  9

Ala Lys Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser 
225                 230                 235                 240 


Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg 
                245                 250                 255     


Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys 
            260                 265                 270         


Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala 
        275                 280                 285             


Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala 
    290                 295                 300                 


Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly 
305                 310                 315                 320 


Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn 
                325                 330                 335     


Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly 
            340                 345                 350         


Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp 
        355                 360                 365             


Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    370                 375                 380             


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser 
1               5                   10  


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr 
1               5                   10                  15  


<210>  12
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala 
225                 230         


<210>  13
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Phe Lys Asn Asn Thr Thr Leu Ser Leu Phe Arg Leu Phe Asn 
1               5                   10                  15      


Ser Phe Pro Leu His Lys Gly Tyr Ile Thr Thr Arg Glu Leu His Gln 
            20                  25                  30          


Leu Ala Leu Ala Asn Leu Ile Phe Met Phe Asn Cys Ala Asp Leu His 
        35                  40                  45              


Phe Pro Pro Gln Met Arg Lys Cys Phe Pro Ile Pro Gly Thr Ser Cys 
    50                  55                  60                  


Leu Phe Cys Pro Lys Thr Lys Thr Leu Phe Pro Val Leu His Leu Ala 
65                  70                  75                  80  


Asn Gln Tyr Leu Cys Phe Leu Cys Gln His Lys His Cys Phe Pro Gln 
                85                  90                  95      


Thr Arg Phe Pro Asp Ser Gln Pro Ser Gln Ala Thr Ser Arg Cys Val 
            100                 105                 110         


Leu Ser Ile Lys Phe Thr Ser Ser Ile Tyr Ile Asn Ser His Asn Tyr 
        115                 120                 125             


Thr Leu Ile Leu Thr Cys Ile Ile Val Arg Val Leu Cys Pro Pro Val 
    130                 135                 140                 


Gly Cys Lys Ser Tyr Lys Asp Arg Gly His Ile His Leu Ala His Pro 
145                 150                 155                 160 


Ser Val Pro Ser Thr Cys His Gly Ser Tyr Gln Leu Thr Ser Thr Gln 
                165                 170                 175     


Tyr Ile Val Trp Ile Ser Lys Tyr Asp Ser Asn Phe Gln His Pro Lys 
            180                 185                 190         


Leu Val Tyr Ser Pro Thr Glu Pro Ala Gln Val Glu His Met Gln Cys 
        195                 200                 205             


Phe Leu Cys Met Cys Leu Gln Arg Glu Glu Arg Glu Ala Leu Leu Leu 
    210                 215                 220                 


Leu Pro Arg Val Thr Ile Leu Thr Arg Leu Ser Ala Glu Ser Thr Asp 
225                 230                 235                 240 


Glu Arg Asp Gly Asp Ser Glu Pro Val Asn Ala Val Cys Arg Thr Ala 
                245                 250                 255     


Leu Ala Phe Val Pro His Glu Ser Asn Val Met Leu Gly Ile His Asn 
            260                 265                 270         


Leu Leu Ile Trp Leu Leu 
        275             


<210>  14
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr Gln Pro Leu 
1               5                   10                  15      


Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg Thr Met Pro 
            20                  25                  30          


Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro 
        35                  40                  45              


Gly Arg Asp Gly Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Leu Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln 
65                  70                  75                  80  


Ala Gly Pro Val Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly 
            100                 105                 110         


Val Pro Gly Pro Ala Gly Arg Glu Gly Ala Leu Gly Lys Gln Gly Asn 
        115                 120                 125             


Ile Gly Pro Gln Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys 
    130                 135                 140                 


Gly Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly 
145                 150                 155                 160 


Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val 
                165                 170                 175     


Pro Gly Asn Thr Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln 
            180                 185                 190         


Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly 
        195                 200                 205             


Ile Pro Gly Asp Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val 
    210                 215                 220                 


Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 
225                 230                 235                 240 


Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 
                245                 250                 255     


Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 
            260                 265                 270         


Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu 
        275                 280                 285             


Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val 
    290                 295                 300                 


Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr 
305                 310                 315                 320 


Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 
                325                 330                 335     


Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 
            340                 345                 350         


Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 
        355                 360                 365             


Arg Leu Val Val Cys Glu Phe 
    370                 375 


<210>  15
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asn Gly Phe Ala Ser Leu Leu Arg Arg Asn Gln Phe Ile Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu Leu Gln Ile Gln Ser Leu Gly Leu Asp Ile Asp Ser 
            20                  25                  30          


Arg Pro Thr Ala Glu Val Cys Ala Thr His Thr Ile Ser Pro Gly Pro 
        35                  40                  45              


Lys Gly Asp Asp Gly Glu Lys Gly Asp Pro Gly Glu Glu Gly Lys His 
    50                  55                  60                  


Gly Lys Val Gly Arg Met Gly Pro Lys Gly Ile Lys Gly Glu Leu Gly 
65                  70                  75                  80  


Asp Met Gly Asp Gln Gly Asn Ile Gly Lys Thr Gly Pro Ile Gly Lys 
                85                  90                  95      


Lys Gly Asp Lys Gly Glu Lys Gly Leu Leu Gly Ile Pro Gly Glu Lys 
            100                 105                 110         


Gly Lys Ala Gly Thr Val Cys Asp Cys Gly Arg Tyr Arg Lys Phe Val 
        115                 120                 125             


Gly Gln Leu Asp Ile Ser Ile Ala Arg Leu Lys Thr Ser Met Lys Phe 
    130                 135                 140                 


Val Lys Asn Val Ile Ala Gly Ile Arg Glu Thr Glu Glu Lys Phe Tyr 
145                 150                 155                 160 


Tyr Ile Val Gln Glu Glu Lys Asn Tyr Arg Glu Ser Leu Thr His Cys 
                165                 170                 175     


Arg Ile Arg Gly Gly Met Leu Ala Met Pro Lys Asp Glu Ala Ala Asn 
            180                 185                 190         


Thr Leu Ile Ala Asp Tyr Val Ala Lys Ser Gly Phe Phe Arg Val Phe 
        195                 200                 205             


Ile Gly Val Asn Asp Leu Glu Arg Glu Gly Gln Tyr Met Phe Thr Asp 
    210                 215                 220                 


Asn Thr Pro Leu Gln Asn Tyr Ser Asn Trp Asn Glu Gly Glu Pro Ser 
225                 230                 235                 240 


Asp Pro Tyr Gly His Glu Asp Cys Val Glu Met Leu Ser Ser Gly Arg 
                245                 250                 255     


Trp Asn Asp Thr Glu Cys His Leu Thr Met Tyr Phe Val Cys Glu Phe 
            260                 265                 270         


Ile Lys Lys Lys Lys 
        275         


<210>  16
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  17
<211>  321
<212>  PRT
<213>  Bos taurus

<400>  17

Met Leu Pro Leu Pro Leu Ser Ile Leu Leu Leu Leu Thr Gln Ser Gln 
1               5                   10                  15      


Ser Phe Leu Gly Glu Glu Met Asp Val Tyr Ser Glu Lys Thr Leu Thr 
            20                  25                  30          


Asp Pro Cys Thr Val Val Val Cys Ala Pro Pro Ala Asp Ser Leu Arg 
        35                  40                  45              


Gly His Asp Gly Arg Asp Gly Lys Glu Gly Pro Gln Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Pro Pro Gly Met Pro Gly Pro Ala Gly Arg Glu Gly Pro 
65                  70                  75                  80  


Ser Gly Arg Gln Gly Ser Met Gly Pro Pro Gly Thr Pro Gly Pro Lys 
                85                  90                  95      


Gly Glu Pro Gly Pro Glu Gly Gly Val Gly Ala Pro Gly Met Pro Gly 
            100                 105                 110         


Ser Pro Gly Pro Thr Gly Leu Lys Gly Glu Arg Gly Thr Pro Gly Pro 
        115                 120                 125             


Gly Gly Ala Ile Gly Pro Gln Gly Pro Ser Gly Ala Met Gly Pro Pro 
    130                 135                 140                 


Gly Leu Lys Gly Asp Arg Gly Asp Pro Gly Glu Lys Gly Ala Lys Gly 
145                 150                 155                 160 


Glu Thr Ser Val Leu Glu Val Asp Thr Leu Arg Gln Arg Met Arg Asn 
                165                 170                 175     


Leu Glu Gly Glu Val Gln Arg Leu Gln Asn Ile Val Thr Gln Tyr Arg 
            180                 185                 190         


Lys Ala Val Leu Phe Pro Asp Gly Gln Ala Val Gly Glu Lys Ile Phe 
        195                 200                 205             


Lys Thr Ala Gly Ala Val Lys Ser Tyr Ser Asp Ala Glu Gln Leu Cys 
    210                 215                 220                 


Arg Glu Ala Lys Gly Gln Leu Ala Ser Pro Arg Ser Ser Ala Glu Asn 
225                 230                 235                 240 


Glu Ala Val Thr Gln Leu Val Arg Ala Lys Asn Lys His Ala Tyr Leu 
                245                 250                 255     


Ser Met Asn Asp Ile Ser Lys Glu Gly Lys Phe Thr Tyr Pro Thr Gly 
            260                 265                 270         


Gly Ser Leu Asp Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asn Arg 
        275                 280                 285             


Ala Lys Asp Glu Gly Pro Glu Asn Cys Leu Glu Ile Tyr Ser Asp Gly 
    290                 295                 300                 


Asn Trp Asn Asp Ile Glu Cys Arg Glu Glu Arg Leu Val Ile Cys Glu 
305                 310                 315                 320 


Phe 
    


<210>  18
<211>  371
<212>  PRT
<213>  Bos taurus

<400>  18

Met Leu Leu Leu Pro Leu Ser Val Leu Leu Leu Leu Thr Gln Pro Trp 
1               5                   10                  15      


Arg Ser Leu Gly Ala Glu Met Lys Ile Tyr Ser Gln Lys Thr Leu Ala 
            20                  25                  30          


Asn Gly Cys Thr Leu Val Val Cys Arg Pro Pro Glu Gly Gly Leu Pro 
        35                  40                  45              


Gly Arg Asp Gly Gln Asp Gly Arg Glu Gly Pro Gln Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Ser Pro Gly Pro Ala Gly Arg Ala Gly Arg Pro Gly Pro 
65                  70                  75                  80  


Ala Gly Pro Ile Gly Pro Lys Gly Asp Asn Gly Ser Ala Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Asp Thr Gly Pro Pro Gly Pro Pro Gly Met Pro Gly 
            100                 105                 110         


Pro Ala Gly Arg Glu Gly Pro Ser Gly Lys Gln Gly Ser Met Gly Pro 
        115                 120                 125             


Pro Gly Thr Pro Gly Pro Lys Gly Asp Thr Gly Pro Lys Gly Gly Met 
    130                 135                 140                 


Gly Ala Pro Gly Met Gln Gly Ser Pro Gly Pro Ala Gly Leu Lys Gly 
145                 150                 155                 160 


Glu Arg Gly Ala Pro Gly Glu Leu Gly Ala Pro Gly Ser Ala Gly Val 
                165                 170                 175     


Ala Gly Pro Ala Gly Ala Ile Gly Pro Gln Gly Pro Ser Gly Ala Arg 
            180                 185                 190         


Gly Pro Pro Gly Leu Lys Gly Asp Arg Gly Asp Pro Gly Glu Arg Gly 
        195                 200                 205             


Ala Lys Gly Glu Ser Gly Leu Ala Asp Val Asn Ala Leu Lys Gln Arg 
    210                 215                 220                 


Val Thr Ile Leu Glu Gly Gln Leu Gln Arg Leu Gln Asn Ala Phe Ser 
225                 230                 235                 240 


Arg Tyr Lys Lys Ala Val Leu Phe Pro Asp Gly Gln Ala Val Gly Lys 
                245                 250                 255     


Lys Ile Phe Lys Thr Ala Gly Ala Val Lys Ser Tyr Ser Asp Ala Gln 
            260                 265                 270         


Gln Leu Cys Arg Glu Ala Lys Gly Gln Leu Ala Ser Pro Arg Ser Ala 
        275                 280                 285             


Ala Glu Asn Glu Ala Val Ala Gln Leu Val Arg Ala Lys Asn Asn Asp 
    290                 295                 300                 


Ala Phe Leu Ser Met Asn Asp Ile Ser Thr Glu Gly Lys Phe Thr Tyr 
305                 310                 315                 320 


Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Ser Gly Glu Pro 
                325                 330                 335     


Asn Asn Asn Asn Ala Gly Gln Pro Glu Asn Cys Val Gln Ile Tyr Arg 
            340                 345                 350         


Glu Gly Lys Trp Asn Asp Val Pro Cys Ser Glu Pro Leu Leu Val Ile 
        355                 360                 365             


Cys Glu Phe 
    370     


<210>  19
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg Gly Asn Leu Ala Leu Val Gly Val Leu Ile Ser Leu Ala Phe 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly His Pro Gln Pro Ala Gly Asp Asp Ala 
            20                  25                  30          


Cys Ser Val Gln Ile Leu Val Pro Gly Leu Lys Gly Asp Ala Gly Glu 
        35                  40                  45              


Lys Gly Asp Lys Gly Ala Pro Gly Arg Pro Gly Arg Val Gly Pro Thr 
    50                  55                  60                  


Gly Glu Lys Gly Asp Met Gly Asp Lys Gly Gln Lys Gly Ser Val Gly 
65                  70                  75                  80  


Arg His Gly Lys Ile Gly Pro Ile Gly Ser Lys Gly Glu Lys Gly Asp 
                85                  90                  95      


Ser Gly Asp Ile Gly Pro Pro Gly Pro Asn Gly Glu Pro Gly Leu Pro 
            100                 105                 110         


Cys Glu Cys Ser Gln Leu Arg Lys Ala Ile Gly Glu Met Asp Asn Gln 
        115                 120                 125             


Val Ser Gln Leu Thr Ser Glu Leu Lys Phe Ile Lys Asn Ala Val Ala 
    130                 135                 140                 


Gly Val Arg Glu Thr Glu Ser Lys Ile Tyr Leu Leu Val Lys Glu Glu 
145                 150                 155                 160 


Lys Arg Tyr Ala Asp Ala Gln Leu Ser Cys Gln Gly Arg Gly Gly Thr 
                165                 170                 175     


Leu Ser Met Pro Lys Asp Glu Ala Ala Asn Gly Leu Met Ala Ala Tyr 
            180                 185                 190         


Leu Ala Gln Ala Gly Leu Ala Arg Val Phe Ile Gly Ile Asn Asp Leu 
        195                 200                 205             


Glu Lys Glu Gly Ala Phe Val Tyr Ser Asp His Ser Pro Met Arg Thr 
    210                 215                 220                 


Phe Asn Lys Trp Arg Ser Gly Glu Pro Asn Asn Ala Tyr Asp Glu Glu 
225                 230                 235                 240 


Asp Cys Val Glu Met Val Ala Ser Gly Gly Trp Asn Asp Val Ala Cys 
                245                 250                 255     


His Thr Thr Met Tyr Phe Met Cys Glu Phe Asp Lys Glu Asn Met 
            260                 265                 270     


<210>  20
<211>  371
<212>  PRT
<213>  Bos taurus

<400>  20

Met Leu Leu Leu Pro Leu Ser Val Leu Leu Leu Leu Thr Gln Pro Trp 
1               5                   10                  15      


Arg Ser Leu Gly Ala Glu Met Thr Thr Phe Ser Gln Lys Ile Leu Ala 
            20                  25                  30          


Asn Ala Cys Thr Leu Val Met Cys Ser Pro Leu Glu Ser Gly Leu Pro 
        35                  40                  45              


Gly His Asp Gly Gln Asp Gly Arg Glu Cys Pro His Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Ser Pro Gly Pro Ala Gly Arg Ala Gly Arg Pro Gly Trp 
65                  70                  75                  80  


Val Gly Pro Ile Gly Pro Lys Gly Asp Asn Gly Phe Val Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Pro Gly Met Pro Gly 
            100                 105                 110         


Pro Ala Gly Arg Glu Gly Pro Ser Gly Lys Gln Gly Ser Met Gly Pro 
        115                 120                 125             


Pro Gly Thr Pro Gly Pro Lys Gly Glu Thr Gly Pro Lys Gly Gly Val 
    130                 135                 140                 


Gly Ala Pro Gly Ile Gln Gly Phe Pro Gly Pro Ser Gly Leu Lys Gly 
145                 150                 155                 160 


Glu Lys Gly Ala Pro Gly Glu Thr Gly Ala Pro Gly Arg Ala Gly Val 
                165                 170                 175     


Thr Gly Pro Ser Gly Ala Ile Gly Pro Gln Gly Pro Ser Gly Ala Arg 
            180                 185                 190         


Gly Pro Pro Gly Leu Lys Gly Asp Arg Gly Asp Pro Gly Glu Thr Gly 
        195                 200                 205             


Ala Lys Gly Glu Ser Gly Leu Ala Glu Val Asn Ala Leu Lys Gln Arg 
    210                 215                 220                 


Val Thr Ile Leu Asp Gly His Leu Arg Arg Phe Gln Asn Ala Phe Ser 
225                 230                 235                 240 


Gln Tyr Lys Lys Ala Val Leu Phe Pro Asp Gly Gln Ala Val Gly Glu 
                245                 250                 255     


Lys Ile Phe Lys Thr Ala Gly Ala Val Lys Ser Tyr Ser Asp Ala Glu 
            260                 265                 270         


Gln Leu Cys Arg Glu Ala Lys Gly Gln Leu Ala Ser Pro Arg Ser Ser 
        275                 280                 285             


Ala Glu Asn Glu Ala Val Thr Gln Met Val Arg Ala Gln Glu Lys Asn 
    290                 295                 300                 


Ala Tyr Leu Ser Met Asn Asp Ile Ser Thr Glu Gly Arg Phe Thr Tyr 
305                 310                 315                 320 


Pro Thr Gly Glu Ile Leu Val Tyr Ser Asn Trp Ala Asp Gly Glu Pro 
                325                 330                 335     


Asn Asn Ser Asp Glu Gly Gln Pro Glu Asn Cys Val Glu Ile Phe Pro 
            340                 345                 350         


Asp Gly Lys Trp Asn Asp Val Pro Cys Ser Lys Gln Leu Leu Val Ile 
        355                 360                 365             


Cys Glu Phe 
    370     


