                         SEQUENCE LISTING

<110>  Howard Hughes Medical Institute
 
<120>  GENETICALLY ENCODED CALCIUM (GECIs) INDICATORS AND METHODS OF 
       MAKING AND USING

<130>  30872-0028WO1

<140>  PCT/US2021/051844
<141>  2021-09-23

<150>  US 63/082,222
<151>  2020-09-23

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Leu Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  2
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgcccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gactgaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  3
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Met Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Tyr Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly His Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  4
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgccatgct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatacaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gacacaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  5
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Gly Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Tyr Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  6
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcggccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatacaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gacagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  7
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  8
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgcccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gacagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  9
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Ser Thr Ala Lys 
            420         


<210>  10
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgcccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gacagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgagcaca     1260

gcgaagtaa                                                             1269


<210>  11
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Asn Ala Val Lys Ile Ser Ala Arg Leu Ser Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  12
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaacgcc       60

gtgaagatct ccgcccgcct gtccggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctgg ggcagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  13
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Gln Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  14
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgcccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gacagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgcaggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  15
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Tyr Lys Gln 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly His Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  16
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgcccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatacaa acaagctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gacacaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  17
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Thr Ala Val Lys Ile Ile Ala Arg Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Glu Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Lys Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  18
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaccgcc       60

gtgaagatca tcgcccgcct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt ggagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctcg gaaagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  19
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Asn Ala Val Lys Ile Ser Ala Ser Leu Met Gly Leu Glu Asn 
            20                  25                  30          


Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
        35                  40                  45              


His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His 
    50                  55                  60                  


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
65                  70                  75                  80  


Asn His Tyr Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu 
                85                  90                  95      


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
            100                 105                 110         


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met 
        115                 120                 125             


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
    130                 135                 140                 


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
145                 150                 155                 160 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
                165                 170                 175     


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
            180                 185                 190         


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
        195                 200                 205             


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg 
    210                 215                 220                 


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
225                 230                 235                 240 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
                245                 250                 255     


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
            260                 265                 270         


Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
        275                 280                 285             


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
    290                 295                 300                 


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
305                 310                 315                 320 


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Ile 
                325                 330                 335     


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr Arg 
            340                 345                 350         


Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys Asp 
        355                 360                 365             


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
    370                 375                 380                 


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
385                 390                 395                 400 


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
                405                 410                 415     


Met Met Thr Ala Lys 
            420     


<210>  20
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaacgcc       60

gtgaagatct ccgcctccct gatgggcctc gagaacgtct atatcaaggc cgacaagcag      120

aagaacggca tcaaggcgaa cttccacatc cgccacaaca tcgaggacgg cggcgtgcag      180

ctcgcctacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac      240

aaccactacc tgagcgtgca gtccaaactt tcgaaagacc ccaacgagaa gcgcgatcac      300

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac      360

aagggcggta ccggagggag catggtgagc aagggcgagg agctgttcac cggggtggtg      420

cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag      480

ggtgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag      540

ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca gtgcttcagc      600

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac      660

atccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg      720

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag      780

gacggcaaca tcctggggca caagctggag tacaacctgc cggaccaact gactgaagag      840

cagatcgcag aatttaaaga ggctttctcc ctatttgaca aggacgggga tgggacaata      900

acaaccaagg agctggggac ggtgatgcgg tctctggggc agaaccccac agaagcagag      960

ctgcaggaca tgatcaatga agtagatgcc gacggtgacg gcacaatcga cttccctgag     1020

ttcctgacaa tgatggcaag aaaaatgaaa tacagggaca cggaagaaga aattagagaa     1080

gcgttcggtg tgtttgataa ggatggcaat ggctacatca gtgcagcaga gcttcgccac     1140

gtgatgacaa accttggaga gaagttaaca gatgaagagg ttgatgaaat gatcagggaa     1200

gcagacatcg atggggatgg tcaggtaaac tacgaagagt ttgtacaaat gatgacagcg     1260

aagtaa                                                                1266


<210>  21
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Met His His His His His His Thr Arg Arg Lys Lys Thr Phe Lys Glu 
1               5                   10                  15      


Val Ala Asn Ala Val Lys Ile Ser Ala Ser Leu Met Gly Leu Lys Ile 
            20                  25                  30          


Asn Val Tyr Ile Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
        35                  40                  45              


Phe His Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr 
    50                  55                  60                  


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
65                  70                  75                  80  


Asp Asn His Tyr Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn 
                85                  90                  95      


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
            100                 105                 110         


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser 
        115                 120                 125             


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    130                 135                 140                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
145                 150                 155                 160 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                165                 170                 175     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            180                 185                 190         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        195                 200                 205             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu 
    210                 215                 220                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
225                 230                 235                 240 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                245                 250                 255     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            260                 265                 270         


Asn Leu Pro Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu 
        275                 280                 285             


Ala Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys 
    290                 295                 300                 


Glu Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala 
305                 310                 315                 320 


Glu Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr 
                325                 330                 335     


Ile Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr 
            340                 345                 350         


Arg Asp Thr Glu Glu Glu Ile Arg Glu Ala Phe Gly Val Phe Asp Lys 
        355                 360                 365             


Asp Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr 
    370                 375                 380                 


Asn Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg 
385                 390                 395                 400 


Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val 
                405                 410                 415     


Gln Met Met Thr Ala Lys 
            420         


<210>  22
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
atgcatcatc accatcatca cacgcgtcgc aagaagacct tcaaggaggt ggccaacgcc       60

gtgaagatct ccgcctctct gatgggcctg aagatcaacg tctatatcaa ggccgacaag      120

cagaagaacg gcatcaaggc gaacttccac atccgccaca acatcgagga cggcggcgtg      180

cagctcgcct accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc      240

gacaaccact acctgagcgt gcagtccaaa ctttcgaaag accccaacga gaagcgcgat      300

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg      360

tacaagggcg gtaccggagg gagcatggtg agcaagggcg aggagctgtt caccggggtg      420

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      480

gagggtgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      540

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      600

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      660

tacatccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      720

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      780

gaggacggca acatcctggg gcacaagctg gagtacaacc tgccggacca actgactgaa      840

gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg ggatgggaca      900

ataacaacca aggagctggg gacggtgatg cggtctctgg ggcagaaccc cacagaagca      960

gagctgcagg acatgatcaa tgaagtagat gccgacggtg acggcacaat cgacttccct     1020

gagttcctga caatgatggc aagaaaaatg aaatacaggg acacggaaga agaaattaga     1080

gaagcgttcg gtgtgtttga taaggatggc aatggctaca tcagtgcagc agagcttcgc     1140

cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga aatgatcagg     1200

gaagcagaca tcgatgggga tggtcaggta aactacgaag agtttgtaca aatgatgaca     1260

gcgaagtaa                                                             1269


<210>  23
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Met Gly Ser His His His His His His Gly Met Ala Ser Met Thr Gly 
1               5                   10                  15      


Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Leu 
            20                  25                  30          


Ala Thr Met Val Asp Ser Ser Arg Arg Lys Trp Asn Lys Thr Gly His 
        35                  40                  45              


Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Leu Glu Asn Val Tyr Ile 
    50                  55                  60                  


Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
65                  70                  75                  80  


His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln 
                85                  90                  95      


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
            100                 105                 110         


Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
        115                 120                 125             


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
    130                 135                 140                 


Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys 
145                 150                 155                 160 


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
                165                 170                 175     


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
            180                 185                 190         


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
        195                 200                 205             


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
    210                 215                 220                 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
225                 230                 235                 240 


Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe 
                245                 250                 255     


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
            260                 265                 270         


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
        275                 280                 285             


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Leu Pro Asp 
    290                 295                 300                 


Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Leu Phe Ser Leu 
305                 310                 315                 320 


Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr 
                325                 330                 335     


Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp 
            340                 345                 350         


Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Ile Asp Phe Pro 
        355                 360                 365             


Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Tyr Thr Asp Ser Glu 
    370                 375                 380                 


Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly 
385                 390                 395                 400 


Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu 
                405                 410                 415     


Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile 
            420                 425                 430         


Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr 
        435                 440                 445             


Ala Lys 
    450 


<210>  24
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
atgggttctc atcatcatca tcatcatggt atggctagca tgactggtgg acagcaaatg       60

ggtcgggatc tgtacgacga tgacgataag gatctcgcca ccatggtcga ctcatcacgt      120

cgtaagtgga ataagacagg tcacgcagtc agagctatag gtcggctgag ctcactcgag      180

aacgtctata tcaaggccga caagcagaag aacggcatca aggcgaactt caagatccgc      240

cacaacatcg aggacggcgg cgtgcagctc gcctaccact accagcagaa cacccccatc      300

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcgtgcagtc caaactttcg      360

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg      420

atcactctcg gcatggacga gctgtacaag ggcggtaccg gagggagcat ggtgagcaag      480

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      540

ggccacaagt tcagcgtgtc cggcgagggt gagggcgatg ccacctacgg caagctgacc      600

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      660

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      720

ttcaagtccg ccatgcccga aggctacatc caggagcgca ccatcttctt caaggacgac      780

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      840

gagcttaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      900

aacctgccgg accaactgac tgaagagcag atcgcagaat ttaaagagct gttctcccta      960

tttgacaagg acggggatgg gacaataaca accaaggagc tggggacggt gatgcggtct     1020

ctggggcaga accccacaga agcagagctg caggacatga tcaatgaagt agatgccgac     1080

ggtgacggca caatcgactt ccctgagttc ctgacaatga tggcaagaaa aatgaaatac     1140

acagacagtg aagaagaaat tagagaagcg ttccgtgtgt ttgataagga tggcaatggc     1200

tacatcagtg cagcagagct tcgccacgtg atgacaaacc ttggagagaa gttaacagat     1260

gaagaggttg atgaaatgat cagggaagca gacatcgatg gggatggtca ggtaaactac     1320

gaagagtttg tacaaatgat gacagcgaag taa                                  1353


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

Ala Arg Arg Lys Trp Gln Lys Thr Gly His Ala Val Arg Ala Ile Gly 
1               5                   10                  15      


Arg Leu Ser Ser 
            20  


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu Thr 
1               5                   10                  15      


Thr Met Leu Ala Thr Arg Asn Phe Ser 
            20                  25  


<210>  27
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Val Arg Val Ile Pro Arg Leu Asp Thr Leu Ile Leu Val Lys Ala Met 
1               5                   10                  15      


Gly His Arg Lys Arg Phe Gly Asn Pro Phe Arg 
            20                  25          


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Lys Arg Phe Ser Phe Lys Lys Ser Phe Lys Leu Ser Gly Phe Ser 
1               5                   10                  15      


Phe Lys Lys 
            


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Arg Lys Lys Thr Phe Lys Glu Val Ala Asn Ala Val Lys Ile Ser Ala 
1               5                   10                  15      


Ser Leu Met Gly 
            20  


<210>  30
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

Gly Gly Phe Arg Arg Ile Ala Arg Leu Val Gly Val Leu Arg Glu Trp 
1               5                   10                  15      


Ala Tyr Arg 
            


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  31

Arg Lys Lys Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg 
1               5                   10                  15      


Leu Ser Arg 
            


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Lys Ser Lys Lys Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Arg 
1               5                   10                  15      


Arg Ala Val Val Ala Cys Phe Arg Met 
            20                  25  


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Lys Phe Tyr Ala Thr Phe Leu Ile Gln Glu Tyr Phe Arg Lys Phe Lys 
1               5                   10                  15      


Lys 
    


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Ala Ser Ala Ser Pro Trp Lys Ser Ala Arg Leu Met Val His Thr Val 
1               5                   10                  15      


Ala Thr Phe Asn Ser Ile Lys Glu Arg 
            20                  25  


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Lys Lys Lys Ala Thr Phe Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser 
1               5                   10                  15      


Phe Lys Arg 
            


<210>  36
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Leu Arg Arg Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln 
1               5                   10                  15      


Thr Gln Ile Lys Val Val Lys Ala Phe His Ser 
            20                  25          


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  37

Ala Phe Ile Ile Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys 
1               5                   10                  15  


<210>  38
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  38

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala 
            


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  39

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


<210>  40
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  40

Ala Ala Gly Ser Gly Trp Arg Lys Ile Lys Leu Ala Val Arg Gly Ala 
1               5                   10                  15      


Gln Ala Lys 
            


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  41

Lys Arg Arg Ala Ile Gly Phe Lys Lys Leu Ala Glu Ala Val Lys Phe 
1               5                   10                  15      


Ser Ala Lys Leu Met Gly 
            20          


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  42

Lys Phe Tyr Ala Thr Phe Leu Ile Gln Glu His Phe Arg Lys Phe Met 
1               5                   10                  15      


Lys Arg Gln Glu Glu 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Lys Ile Tyr Ala Ala Met Met Ile Met Glu Tyr Tyr Arg Gln Ser Lys 
1               5                   10                  15      


Ala Lys Lys Leu Gln 
            20      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met Thr Leu Ser Gln Val 
1               5                   10                  15      


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Arg Arg Arg Glu Ile Arg Phe Arg Val Leu Val Lys Val Val Phe Phe 
1               5                   10                  15      


Ser Ser 
        


<210>  46
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Ser Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile Leu Thr Thr Met 
1               5                   10                  15      


Leu Ala Thr Ala Ser 
            20      


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  47

Gly Arg Val Ser Gly Arg Asn Trp Lys Asn Phe Ala Leu Val Pro Leu 
1               5                   10                  15      


Leu Arg Asp Ala Ser 
            20      


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  48

Glu Arg Leu Gln Gln Trp Arg Lys Ala Ala Leu Val Leu Asn Ala Ser 
1               5                   10                  15      


Arg Arg Phe Arg Tyr 
            20      


<210>  49
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  49

Arg Glu Met Arg Gln Lys Ile Arg Ser His Ala His Ala Leu Leu Ala 
1               5                   10                  15      


Ala Asn Arg Phe Met Asp Met 
            20              


<210>  50
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  50

Ala Arg Lys Glu Val Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met 
1               5                   10                  15      


Ala Arg Val Phe Ser Val Leu Arg 
            20                  


<210>  51
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  51

Asn His Trp Gln Lys Ile Arg Thr Met Val Asn Leu Pro Val Ile Ser 
1               5                   10                  15      


Pro Phe Lys Ser Ser 
            20      


<210>  52
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  52

Lys Arg Asn Lys Ala Leu Lys Lys Ile Arg Lys Leu Gln Lys Arg Gly 
1               5                   10                  15      


Leu Ile Gln Met Thr 
            20      


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  53

Ser Ser Arg Arg Lys Trp Asn Lys Thr Gly His Ala Val Arg Ala Ile 
1               5                   10                  15      


Gly Arg Leu Ser Ser 
            20      


<210>  54
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  54

Val Lys Leu Ile Pro Ser Leu Thr Thr Val Ile Leu Val Lys Ser Met 
1               5                   10                  15      


Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe 
            20                  25      


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  55

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


