                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  IMMUNOTHERAPY TARGETING SOX2 ANTIGENS

<130>  360056.47701WO

<140>  PCT
<141>  2021-09-23

<150>  US 63/083,069
<151>  2020-09-24

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  SOX2 peptide (275-283)

<400>  2

Ser Met Tyr Leu Pro Gly Ala Glu Val 
1               5                   


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  SOX2 peptide (216-225)

<400>  3

Tyr Met Asn Gly Ser Pro Thr Tyr Ser Met 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  SOX2 peptide (306-314)

<400>  4

Thr Ala Ile Asn Gly Thr Leu Pro Leu 
1               5                   


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  SOX2 peptide (277-287)

<400>  5

Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala 
1               5                   10      


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  SOX2 peptide (58-66)

<400>  6

Lys Met Ala Gln Glu Asn Pro Lys Met 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  SOX2 peptide (118-127)

<400>  7

Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu 
1               5                   10  


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic hTCR_Calpha-R

<400>  8
cagccgcagc gtcatgagca gatta                                             25


<210>  9
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic hTCR_Cb1-R

<400>  9
ccacttccag ggctgccttc agaaatc                                           27


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic hTCR_Cb2-R

<400>  10
tgggatggtt ttggagctag cctctgg                                           27


<210>  11
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  11
atggcttctc tcctgttctt ctgtggcgcc ttttacctgc tgggaacagg ctctatggat       60

gctgatgtga cacagacccc cagaaacaga atcaccaaga caggcaagcg gatcatgctg      120

gagtgtagcc agacaaaagg ccacgaccgg atgtactggt atagacaaga tcctgggttg      180

ggccttcgac tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatctct      240

gacggctaca gcgtgagcag acaagctcag gccaagtttt ctctgtctct ggaatctgcc      300

atccctaatc agacagccct gtacttctgt gccaccagcg agtgggatag cacagataca      360

cagtactttg gccccggcac caggctgaca gtgcttgagg acctgaagaa cgtgttcccc      420

ccagaggtgg ccgtgttcga gcctagcgag gccgagatca gccacaccca gaaagccacc      480

ctcgtgtgcc tggccaccgg cttttacccc gaccacgtgg aactgtcttg gtgggtcaac      540

ggcaaagagg tgcacagcgg cgtctgcacc gacccccagc ccctgaaaga gcagcccgcc      600

ctgaacgaca gccggtactg tctgagcagc agactgagag tgtccgccac cttctggcag      660

aacccccgga accacttcag atgccaggtg cagttctacg gcctgagcga gaacgacgag      720

tggacccagg accgggccaa gcccgtgacc cagatcgtgt ctgctgaggc ctggggcaga      780

gccgattgcg gcttcaccag cgagagctac cagcagggcg tgctgagcgc caccatcctg      840

tacgagatcc tgctgggcaa ggccaccctg tacgccgtgc tggtgtccgc cctggtgctg      900

atggccatgg tcaagcggaa ggacagccgg ggcggttccg gagccacgaa cttctctctg      960

ttaaagcaag caggagacgt ggaagaaaac cccggtccca tggagacact gcttggcgta     1020

tcactggtga ttctgtggct gcaactggct agagtgaact ctcagcaggg agaagaggat     1080

cctcaagctc tgagcattca ggaaggcgaa aacgctacca tgaattgctc ctacaagacc     1140

agcatcaaca acctgcagtg gtaccggcag aatagcggaa gaggactggt tcacctgatc     1200

ctgatcagaa gcaatgaaag ggagaagcac agcggcagac tgagagttac cctggataca     1260

tccaagaaaa gtagctctct gctgattaca gcctctagag ccgccgatac agccagctac     1320

ttttgtgcca cattaggaca gggagcccag aaactggtgt ttggacaggg cacaagactg     1380

accatcaatc ccaacatcca gaatcctgat cccgccgtgt accagctgcg ggacagcaag     1440

agcagcgaca agagcgtgtg cctgttcacc gacttcgaca gccagaccaa cgtgtcccag     1500

agcaaggaca gcgacgtgta catcaccgat aagtgcgtgc tggacatgcg gagcatggac     1560

ttcaagagca acagcgccgt ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc     1620

ttcaacaaca gcattatccc cgaggacaca ttcttcccaa gccccgagag cagctgcgac     1680

gtgaagctgg tggaaaagag cttcgagaca gacaccaacc tgaacttcca gaacctcagc     1740

gtgatcggct tccggatcct gctgctgaag gtggccggct tcaacctgct gatgaccctg     1800

cggctgtggt ccagctga                                                   1818


<210>  12
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 TCRbeta-P2A-TCRalpha

<400>  12

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Ser Glu Trp Asp Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu 
305                 310                 315                 320 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Thr 
                325                 330                 335     


Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu Ala Arg Val 
            340                 345                 350         


Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu 
        355                 360                 365             


Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn 
    370                 375                 380                 


Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile 
385                 390                 395                 400 


Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val 
                405                 410                 415     


Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser 
            420                 425                 430         


Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Leu Gly Gln Gly 
        435                 440                 445             


Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg Leu Thr Ile Asn Pro 
    450                 455                 460                 


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
465                 470                 475                 480 


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
                485                 490                 495     


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys 
            500                 505                 510         


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
        515                 520                 525             


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
    530                 535                 540                 


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
545                 550                 555                 560 


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
                565                 570                 575     


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
            580                 585                 590         


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605 


<210>  13
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 TCRVbeta

<400>  13

Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr Lys Thr Gly 
1               5                   10                  15      


Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His Asp Arg Met 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Tyr 
        35                  40                  45              


Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser Asp Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser Leu Glu Ser 
65                  70                  75                  80  


Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr Ser Glu Trp 
                85                  90                  95      


Asp Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu 
        


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR1beta

<400>  14

Lys Gly His Asp Arg 
1               5   


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR2beta

<400>  15

Ser Phe Asp Val Lys Asp 
1               5       


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR3beta

<400>  16

Ala Thr Ser Glu Trp Asp Ser Thr Asp Thr Gln Tyr 
1               5                   10          


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR3beta-junction

<400>  17

Cys Ala Thr Ser Glu Trp Asp Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 TCRValpha

<400>  18

Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile Asn Asn Leu 
            20                  25                  30          


Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu 
        35                  40                  45              


Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu Arg Val Thr 
    50                  55                  60                  


Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr Ala Ser Arg 
65                  70                  75                  80  


Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Leu Gly Gln Gly Ala 
                85                  90                  95      


Gln Lys Leu Val Phe Gly Gln Gly Thr Arg Leu Thr Ile Asn Pro Asn 
            100                 105                 110         


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR1alpha

<400>  19

Thr Ser Ile Asn Asn 
1               5   


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR2alpha

<400>  20

Ile Arg Ser Asn Glu Arg Glu 
1               5           


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR3alpha

<400>  21

Ala Thr Leu Gly Gln Gly Ala Gln Lys Leu Val 
1               5                   10      


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#01 CDR3alpha-junction

<400>  22

Cys Ala Thr Leu Gly Gln Gly Ala Gln Lys Leu Val Phe 
1               5                   10              


<210>  23
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  23
atgggcatca gactcctttg cagggtggcc ttttgctttc tggctgtggg attagtggac       60

gtgaaggtta cccagtccag tagatacctt gtcaagagaa ccggcgagaa ggtgttcctg      120

gaatgtgtgc aggacatgga tcacgagaat atgttctggt acagacagga ccctggactg      180

ggactgagac tgatctactt cagctacgac gtgaagatga aggagaaggg cgatatccct      240

gagggctaca gcgtgagcag agagaaaaag gagaggttca gcctgattct ggaaagcgcc      300

agcacaaatc aaacatctat gtatttatgc gcctcttctc tgattctggc cggaagaaat      360

acaggcgagc tgttttttgg cgagggctct agactgaccg tgcttgagga cctgaagaac      420

gtgttccccc cagaggtggc cgtgttcgag cctagcgagg ccgagatcag ccacacccag      480

aaagccaccc tcgtgtgcct ggccaccggc ttttaccccg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcacagcggc gtctgcaccg acccccagcc cctgaaagag      600

cagcccgccc tgaacgacag ccggtactgt ctgagcagca gactgagagt gtccgccacc      660

ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttctacgg cctgagcgag      720

aacgacgagt ggacccagga ccgggccaag cccgtgaccc agatcgtgtc tgctgaggcc      780

tggggcagag ccgattgcgg cttcaccagc gagagctacc agcagggcgt gctgagcgcc      840

accatcctgt acgagatcct gctgggcaag gccaccctgt acgccgtgct ggtgtccgcc      900

ctggtgctga tggccatggt caagcggaag gacagccggg gcggttccgg agccacgaac      960

ttctctctgt taaagcaagc aggagacgtg gaagaaaacc ccggtcccat gaagaagcac     1020

ctgaccacgt tcctggtgat tctgtggctg tacttctaca ggggcaacgg caagaatcag     1080

gttgagcagt ctcctcagtc cctgattatt cttgagggca agaattgtac cctgcagtgc     1140

aactacacag tgagcccttt cagcaacctg aggtggtaca agcaggatac aggaagagga     1200

cctgtgagtt tgacaatcat gaccttcagc gagaacacca agagcaacgg cagatataca     1260

gccaccctgg atgccgacac aaagcagtct tctctgcaca ttacagcctc tcagctgagc     1320

gattctgcca gctacatctg cgtggtgaga gacagcaatt accagctgat ttggggagct     1380

ggcacaaagc tgatcatcaa gcccgacatc cagaatcccg atcctgctgt gtaccagctg     1440

cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc     1500

aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg     1560

cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc     1620

tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag     1680

agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc     1740

cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg     1800

ctgatgaccc tgcggctgtg gtccagctga                                      1830


<210>  24
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 TCRbeta-P2A-TCRalpha,

<400>  24

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ile Leu Ala Gly Arg Asn Thr Gly Glu Leu Phe Phe Gly Glu 
        115                 120                 125             


Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn 
305                 310                 315                 320 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                325                 330                 335     


Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
            340                 345                 350         


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
        355                 360                 365             


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
    370                 375                 380                 


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
385                 390                 395                 400 


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
                405                 410                 415     


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
            420                 425                 430         


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
        435                 440                 445             


Val Arg Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu 
    450                 455                 460                 


Ile Ile Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
465                 470                 475                 480 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
                485                 490                 495     


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
            500                 505                 510         


Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
        515                 520                 525             


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
    530                 535                 540                 


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
545                 550                 555                 560 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
                565                 570                 575     


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
            580                 585                 590         


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
        595                 600                 605             


Ser 
    


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 TCRVbeta

<400>  25

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Ser Leu Ile 
                85                  90                  95      


Leu Ala Gly Arg Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
            100                 105                 110         


Leu Thr Val Leu Glu 
        115         


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR1beta

<400>  26

Met Asp His Glu Asn 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR2beta

<400>  27

Ser Tyr Asp Val Lys Met 
1               5       


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR3beta

<400>  28

Ala Ser Ser Leu Ile Leu Ala Gly Arg Asn Thr Gly Glu Leu Phe 
1               5                   10                  15  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR3beta-junction

<400>  29

Cys Ala Ser Ser Leu Ile Leu Ala Gly Arg Asn Thr Gly Glu Leu Phe 
1               5                   10                  15      


Phe 
    


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 TCRValpha

<400>  30

Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly 
1               5                   10                  15      


Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn 
            20                  25                  30          


Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr 
        35                  40                  45              


Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala 
    50                  55                  60                  


Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val Arg Asp Ser Asn 
                85                  90                  95      


Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asp 
            100                 105                 110         


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR1alpha

<400>  31

Val Ser Pro Phe Ser Asn 
1               5       


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR2alpha

<400>  32

Met Thr Phe Ser Glu Asn Thr 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR3alpha

<400>  33

Val Val Arg Asp Ser Asn Tyr Gln Leu Ile 
1               5                   10  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#02 CDR3alpha-junction

<400>  34

Cys Val Val Arg Asp Ser Asn Tyr Gln Leu Ile Trp 
1               5                   10          


<210>  35
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  35
atgggacctg gactgttatg ttgggttctg ctgtgtctgc ttggagctgg acctgttgat       60

gctggagtta cacagagccc tacacacctg atcaagacaa gaggacagca ggtgaccctg      120

agatgtagcc ctatttctgg ccacaagagc gtgagctggt atcagcaggt tttaggacag      180

ggaccccagt tcatcttcca gtactacgag aaggaggaga gaggcagagg caatttccct      240

gacagattta gcgcccggca gttccccaat tatagctctg agctgaacgt gaatgccctg      300

ctgcttggcg attctgctct gtacctgtgt gcctcttctc tgtttatcag cctgatgctg      360

gatacccagt acttcggccc tggcacaaga ctgacagtgc tggaagacct gaagaacgtg      420

ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa      480

gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg      540

gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag      600

cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc      660

tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac      720

gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg      780

ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc      840

atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg      900

gtgctgatgg ccatggtcaa gcggaaggac agccggggcg gttccggagc cacgaacttc      960

tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatggt gaagatccgg     1020

cagttcctcc tggctattct gtggctgcaa ctgtcttgtg tgtcagcagc caagaatgaa     1080

gtggagcagt cccctcagaa cctgaccgca caggaaggcg agtttatcac catcaactgc     1140

agctactccg taggcataag cgccctgcat tggctccagc agcaccctgg aggaggaatt     1200

gtgtctctgt ttatgctgag cagcggaaaa aaaaagcacg gccggctgat tgccaccatc     1260

aacatccagg agaagcatag cagcctacac attacagcgt ctcatcccag ggattctgcc     1320

gtgtacatct gtgccacact gacacaagga ggaagcgaaa aactggtgtt tggcaagggc     1380

acaaagctga ccgtgaatcc ctacatccag aatcccgatc ctgccgtgta ccagctgcgg     1440

gacagcaaga gcagcgacaa gagcgtgtgc ctgttcaccg acttcgacag ccagaccaac     1500

gtgtcccaga gcaaggacag cgacgtgtac atcaccgata agtgcgtgct ggacatgcgg     1560

agcatggact tcaagagcaa cagcgccgtg gcctggtcca acaagagcga cttcgcctgc     1620

gccaacgcct tcaacaacag cattatcccc gaggacacat tcttcccaag ccccgagagc     1680

agctgcgacg tgaagctggt ggaaaagagc ttcgagacag acaccaacct gaacttccag     1740

aacctcagcg tgatcggctt ccggatcctg ctgctgaagg tggccggctt caacctgctg     1800

atgaccctgc ggctgtggtc cagctga                                         1827


<210>  36
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 TCRbeta-P2A-TCRalpha

<400>  36

Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Lys Ser Val Ser Trp Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Phe Ile Ser Leu Met Leu Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu Ser 
            340                 345                 350         


Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn Leu 
        355                 360                 365             


Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser Val 
    370                 375                 380                 


Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly Ile 
385                 390                 395                 400 


Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg Leu 
                405                 410                 415     


Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile Thr 
            420                 425                 430         


Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Thr Leu Thr 
        435                 440                 445             


Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr 
    450                 455                 460                 


Val Asn Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
465                 470                 475                 480 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
                485                 490                 495     


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
            500                 505                 510         


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
        515                 520                 525             


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
    530                 535                 540                 


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
545                 550                 555                 560 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
                565                 570                 575     


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
            580                 585                 590         


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605             


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 TCRVbeta

<400>  37

Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His Lys Ser Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln 
        35                  40                  45              


Tyr Tyr Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala 
65                  70                  75                  80  


Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Phe 
                85                  90                  95      


Ile Ser Leu Met Leu Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu 
        115     


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR1beta

<400>  38

Ser Gly His Lys Ser 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR2beta

<400>  39

Tyr Tyr Glu Lys Glu Glu 
1               5       


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR3beta

<400>  40

Ala Ser Ser Leu Phe Ile Ser Leu Met Leu Asp Thr Gln Tyr 
1               5                   10                  


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR3beta-junction

<400>  41

Cys Ala Ser Ser Leu Phe Ile Ser Leu Met Leu Asp Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  42
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 TCRValpha

<400>  42

Lys Asn Glu Val Glu Gln Ser Pro Gln Asn Leu Thr Ala Gln Glu Gly 
1               5                   10                  15      


Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser Val Gly Ile Ser Ala Leu 
            20                  25                  30          


His Trp Leu Gln Gln His Pro Gly Gly Gly Ile Val Ser Leu Phe Met 
        35                  40                  45              


Leu Ser Ser Gly Lys Lys Lys His Gly Arg Leu Ile Ala Thr Ile Asn 
    50                  55                  60                  


Ile Gln Glu Lys His Ser Ser Leu His Ile Thr Ala Ser His Pro Arg 
65                  70                  75                  80  


Asp Ser Ala Val Tyr Ile Cys Ala Thr Leu Thr Gln Gly Gly Ser Glu 
                85                  90                  95      


Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro Tyr 
            100                 105                 110     


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR1alpha

<400>  43

Val Gly Ile Ser Ala 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR2alpha

<400>  44

Leu Ser Ser Gly Lys 
1               5   


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR3alpha

<400>  45

Ala Thr Leu Thr Gln Gly Gly Ser Glu Lys Leu Val 
1               5                   10          


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#04 CDR3alpha-junction

<400>  46

Cys Ala Thr Leu Thr Gln Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10                  


<210>  47
<211>  1833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  47
atgggcatca gactcctttg cagggtggcc ttttgctttc tggctgtggg attagtggac       60

gtgaaggtta cccagtccag cagatacctg gttaagagaa ccggcgagaa ggtgttcctg      120

gaatgtgtgc aggacatgga tcacgaaaat atgttttggt acagacagga ccctggactg      180

ggactgagac tgatctactt cagctacgac gtgaagatga aggagaaggg cgatatccct      240

gagggctaca gcgtgagcag agagaaaaag gagaggttca gcctgattct ggaaagcgcc      300

agcacaaatc aaacatctat gtacctttgc gcctctagac ctgaaatggg cggaagagga      360

aatcagcctc agcattttgg cgatggcaca agactgagca tcctggagga tctgaacaag      420

gtgttccccc cagaggtggc cgtgttcgag ccttctgagg ccgagatctc ccacacccag      480

aaagccaccc tcgtgtgcct ggccaccggc tttttccccg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcactccggc gtgtgcaccg atccccagcc tctgaaagaa      600

cagcccgccc tgaacgacag ccggtactgc ctgagcagca gactgagagt gtccgccacc      660

ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttctacgg cctgagcgag      720

aacgacgagt ggacccagga cagagccaag cccgtgacac agatcgtgtc tgccgaagcc      780

tggggcagag ccgattgcgg ctttacctcc gtgtcctatc agcagggcgt gctgagcgcc      840

acaatcctgt acgagatcct gctgggcaag gccaccctgt acgccgtgct ggtgtctgcc      900

ctggtgctga tggccatggt caagcggaag gacttcggtt ccggagccac gaacttctct      960

ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatgagcct gtcttctctg     1020

ctgaaggtgg tgactgctag cctctggtta ggacctggaa ttgcccagaa gatcacccag     1080

acacaacctg gcatgtttgt gcaggagaaa gaggctgtga ccctggattg cacctacgat     1140

accagcgatc cttcttacgg ccttttctgg tacaaacagc ctagctccgg cgagatgatc     1200

ttcctgatct accagggcag ctacgaccag cagaacgcaa ccgagggtag atatagcctg     1260

aattttcaga aggcaagaaa gtcagccaac ctggtgatct ctgcctctca actgggcgat     1320

tctgccatgt acttttgtgc catgagagag ggcatgggct tccagaaact ggtgtttggc     1380

acaggcacaa ggctgctggt ttctcccaat atccagaatc ctgaccctgc cgtgtaccag     1440

ctgcgggaca gcaagagcag cgacaagagc gtgtgcctgt tcaccgactt cgacagccag     1500

accaacgtgt cccagagcaa ggacagcgac gtgtacatca ccgataagtg cgtgctggac     1560

atgcggagca tggacttcaa gagcaacagc gccgtggcct ggtccaacaa gagcgacttc     1620

gcctgcgcca acgccttcaa caacagcatt atccccgagg acacattctt cccaagcccc     1680

gagagcagct gcgacgtgaa gctggtggaa aagagcttcg agacagacac caacctgaac     1740

ttccagaacc tcagcgtgat cggcttccgg atcctgctgc tgaaggtggc cggcttcaac     1800

ctgctgatga ccctgcggct gtggtccagc tga                                  1833


<210>  48
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 TCRbeta-P2A-TCRalpha

<400>  48

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Arg Pro Glu Met Gly Gly Arg Gly Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser 
                325                 330                 335     


Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu Gly Pro 
            340                 345                 350         


Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln 
        355                 360                 365             


Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro 
    370                 375                 380                 


Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile 
385                 390                 395                 400 


Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly 
                405                 410                 415     


Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val 
            420                 425                 430         


Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met 
        435                 440                 445             


Arg Glu Gly Met Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg 
    450                 455                 460                 


Leu Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
545                 550                 555                 560 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 



<210>  49
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 TCRVbeta

<400>  49

Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly 
1               5                   10                  15      


Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met 
            20                  25                  30          


Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe 
        35                  40                  45              


Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr 
    50                  55                  60                  


Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser Arg Pro Glu 
                85                  90                  95      


Met Gly Gly Arg Gly Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
            100                 105                 110         


Leu Ser Ile Leu Glu 
        115         


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR1beta

<400>  50

Met Asp His Glu Asn 
1               5   


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR2beta

<400>  51

Ser Tyr Asp Val Lys Met 
1               5       


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR3beta

<400>  52

Ala Ser Arg Pro Glu Met Gly Gly Arg Gly Asn Gln Pro Gln His 
1               5                   10                  15  


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR3beta-junction

<400>  53

Cys Ala Ser Arg Pro Glu Met Gly Gly Arg Gly Asn Gln Pro Gln His 
1               5                   10                  15      


Phe 
    


<210>  54
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 TCRValpha

<400>  54

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu 
                85                  90                  95      


Gly Met Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Ser Pro Asn 
        115     


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR1alpha

<400>  55

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR2alpha

<400>  56

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR3alpha

<400>  57

Ala Met Arg Glu Gly Met Gly Phe Gln Lys Leu Val 
1               5                   10          


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#05 CDR3alpha-junction

<400>  58

Cys Ala Met Arg Glu Gly Met Gly Phe Gln Lys Leu Val Phe 
1               5                   10                  


<210>  59
<211>  1523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  59
atgcttttac tccttctctt gctcggacct gctggatctg gattaggagc tgttgtgtct       60

cagcaccctt cttgggtgat ctgtaaaagc ggcacaagcg tgaaaattga gtgcaggagc      120

ctggattttc aggccaccac catgttctgg tataggcagt tccccaagca gtctctgatg      180

ctgatggcca cctctaatga gggctctaag gccacatatg agcagggcgt agagaaggac      240

aagttcctga tcaaccacgc ctctctgacc ctgtctaccc tgacagttac atctgcccac      300

cctgaggata gcagctttta catctgtagc gccagaggca agacaagccc tagacctgaa      360

acccagtact tcggacctgg cacaagactg ttagttctgg aggacctgaa gaacgtgttc      420

cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc      480

accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc      540

aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc      600

gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg      660

cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac      720

gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc      780

agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc      840

ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg      900

ctgatggcca tggtcaagcg gaaggacagc cggggcggtt ccggagccac gaacttctct      960

ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatggagtc ttcattgggt     1020

ggtgtgctgc tgattctgtg gctgcaggta gattgggtca agagccagaa gatcgagcag     1080

aattctgaag ccctgaacat ccaggagggc aagacagcta cactgacctg caactacacc     1140

aactactctc ctgcttacct gcagtggtac agacaggatc ctggcagagg acctgtgttt     1200

ctgctgctga ttagagaaaa cgaaaaggag aaaagaaaag agagactgaa ggttaccttc     1260

gacacaaccc tgaagcagag cctgtttcac attacagcca gccaacccgc cgattctgcc     1320

acatacctgt gtgctctggg acacaagctg acatttggag gaggaacaag agttctggtg     1380

aagcccaaca tccagaatcc cgatcctgcc gtgtaccagc tgcgggacag caagagcagc     1440

gacaagagcg tgtgcctgtt caccgacttc gacagccaga ccaacgtgtc ccagagcaag     1500

gacagcgacg tgtacatcac cga                                             1523


<210>  60
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 TCRbeta-P2A-TCRalpha

<400>  60

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly 
1               5                   10                  15      


Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr 
            20                  25                  30          


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
        35                  40                  45              


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
    50                  55                  60                  


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
65                  70                  75                  80  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
                85                  90                  95      


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg 
            100                 105                 110         


Gly Lys Thr Ser Pro Arg Pro Glu Thr Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu 
                325                 330                 335     


Ser Ser Leu Gly Gly Val Leu Leu Ile Leu Trp Leu Gln Val Asp Trp 
            340                 345                 350         


Val Lys Ser Gln Lys Ile Glu Gln Asn Ser Glu Ala Leu Asn Ile Gln 
        355                 360                 365             


Glu Gly Lys Thr Ala Thr Leu Thr Cys Asn Tyr Thr Asn Tyr Ser Pro 
    370                 375                 380                 


Ala Tyr Leu Gln Trp Tyr Arg Gln Asp Pro Gly Arg Gly Pro Val Phe 
385                 390                 395                 400 


Leu Leu Leu Ile Arg Glu Asn Glu Lys Glu Lys Arg Lys Glu Arg Leu 
                405                 410                 415     


Lys Val Thr Phe Asp Thr Thr Leu Lys Gln Ser Leu Phe His Ile Thr 
            420                 425                 430         


Ala Ser Gln Pro Ala Asp Ser Ala Thr Tyr Leu Cys Ala Leu Gly His 
        435                 440                 445             


Lys Leu Thr Phe Gly Gly Gly Thr Arg Val Leu Val Lys Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
465                 470                 475                 480 


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
                485                 490                 495     


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
        515                 520                 525             


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
    530                 535                 540                 


Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys 
545                 550                 555                 560 


Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn 
                565                 570                 575     


Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
            580                 585                 590         


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600             


<210>  61
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 TCRVbeta

<400>  61

Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly 
1               5                   10                  15      


Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr 
            20                  25                  30          


Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala 
        35                  40                  45              


Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys 
    50                  55                  60                  


Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr 
65                  70                  75                  80  


Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala 
                85                  90                  95      


Arg Gly Lys Thr Ser Pro Arg Pro Glu Thr Gln Tyr Phe Gly Pro Gly 
            100                 105                 110         


Thr Arg Leu Leu Val Leu Glu 
        115                 


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR1beta

<400>  62

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR2beta

<400>  63

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR3beta

<400>  64

Ser Ala Arg Gly Lys Thr Ser Pro Arg Pro Glu Thr Gln Tyr 
1               5                   10                  


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR3beta-junction

<400>  65

Cys Ser Ala Arg Gly Lys Thr Ser Pro Arg Pro Glu Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  66
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 TCRValpha

<400>  66

Ser Gln Lys Ile Glu Gln Asn Ser Glu Ala Leu Asn Ile Gln Glu Gly 
1               5                   10                  15      


Lys Thr Ala Thr Leu Thr Cys Asn Tyr Thr Asn Tyr Ser Pro Ala Tyr 
            20                  25                  30          


Leu Gln Trp Tyr Arg Gln Asp Pro Gly Arg Gly Pro Val Phe Leu Leu 
        35                  40                  45              


Leu Ile Arg Glu Asn Glu Lys Glu Lys Arg Lys Glu Arg Leu Lys Val 
    50                  55                  60                  


Thr Phe Asp Thr Thr Leu Lys Gln Ser Leu Phe His Ile Thr Ala Ser 
65                  70                  75                  80  


Gln Pro Ala Asp Ser Ala Thr Tyr Leu Cys Ala Leu Gly His Lys Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Val Leu Val Lys Pro Asn 
            100                 105                 


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR1alpha

<400>  67

Asn Tyr Ser Pro Ala Tyr 
1               5       


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR2alpha

<400>  68

Ile Arg Glu Asn Glu Lys Glu 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR3alpha

<400>  69

Ala Leu Gly His Lys Leu Thr 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#06 CDR3alpha-junction

<400>  70

Cys Ala Leu Gly His Lys Leu Thr Phe 
1               5                   


<210>  71
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 TCRbeta-P2A-TCRalpha
       codon-optimized nucleotide

<400>  71
atgggcacaa gactcctttt ctgggtcgcc ttttgtctgc ttggagccga tcataccggc       60

gccggcgtga gccagtctcc cagcaataag gtcaccgaga agggcaaaga tgtggagctg      120

agatgcgacc ctatttctgg ccataccgcc ctgtactggt acagacaatc tctgggacag      180

gggctagagt tcctgatcta ctttcagggc aatagcgccc ccgacaaatc tggacttcct      240

agcgacaggt tttctgccga gagaacagga ggatctgttt ctaccctgac catccagaga      300

acacagcagg aggattctgc cgtgtacctg tgtgccagca gaagaacagg atggagctac      360

aatgagcagt tctttggccc tggaaccaga ctgacagtgc tggaggacct gaagaacgtg      420

ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa      480

gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg      540

gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag      600

cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc      660

tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac      720

gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg      780

ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc      840

atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg      900

gtgctgatgg ccatggtcaa gcggaaggac agccggggcg gttccggagc cacgaacttc      960

tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgat cagcctgaga     1020

gtcctgctcg tgattctgtg gctgcaactg tcttgggttt ggagccagag aaaagaagtg     1080

gagcaggatc ctggcccctt taatgtgcct gaaggagcta cagtggcctt caactgcaca     1140

tacagcaaca gcgcctcaca gagcttcttc tggtacagac aggactgcag gaaggagcct     1200

aagctgctga tgtctgtgta tagcagcggc aatgaggatg gcagatttac agcccagctg     1260

aaccgggctt ctcagtacat ctctctgctg atcagggata gcaagctgag cgattctgct     1320

acatacctct gcgtggtgta cgtggagtct ggaggcagct atatccctac attcggcaga     1380

ggaacaagcc tgattgtgca cccctatatc cagaatcccg accctgctgt gtaccagctg     1440

cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc     1500

aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg     1560

cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc     1620

tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag     1680

agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc     1740

cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg     1800

ctgatgaccc tgcggctgtg gtccagctga                                      1830


<210>  72
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 TCRbeta-P2A-TCRalpha

<400>  72

Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Arg Arg Thr Gly Trp Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp 
            340                 345                 350         


Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn 
        355                 360                 365             


Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser 
    370                 375                 380                 


Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro 
385                 390                 395                 400 


Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe 
                405                 410                 415     


Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg 
            420                 425                 430         


Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Tyr Val 
        435                 440                 445             


Glu Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu 
    450                 455                 460                 


Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
465                 470                 475                 480 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
                485                 490                 495     


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
            500                 505                 510         


Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
        515                 520                 525             


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
    530                 535                 540                 


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
545                 550                 555                 560 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
                565                 570                 575     


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
            580                 585                 590         


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
        595                 600                 605             


Ser 
    



<210>  73
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 TCRVbeta

<400>  73

Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly 
1               5                   10                  15      


Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr 
        35                  40                  45              


Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln 
65                  70                  75                  80  


Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Arg Arg 
                85                  90                  95      


Thr Gly Trp Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu 
        115     


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR1beta

<400>  74

Ser Gly His Thr Ala 
1               5   


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR2beta

<400>  75

Phe Gln Gly Asn Ser Ala 
1               5       


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR3beta

<400>  76

Ala Ser Arg Arg Thr Gly Trp Ser Tyr Asn Glu Gln Phe 
1               5                   10              


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR3beta-junction

<400>  77

Cys Ala Ser Arg Arg Thr Gly Trp Ser Tyr Asn Glu Gln Phe Phe 
1               5                   10                  15  


<210>  78
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 TCRValpha

<400>  78

Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu Gly 
1               5                   10                  15      


Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu Met 
        35                  40                  45              


Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln Leu 
    50                  55                  60                  


Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys Leu 
65                  70                  75                  80  


Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Tyr Val Glu Ser Gly Gly 
                85                  90                  95      


Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val His Pro 
            100                 105                 110         


Tyr 
    


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR1alpha

<400>  79

Asn Ser Ala Ser Gln Ser 
1               5       


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR2alpha

<400>  80

Val Tyr Ser Ser Gly Asn 
1               5       


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR3alpha

<400>  81

Val Val Tyr Val Glu Ser Gly Gly Ser Tyr Ile Pro Thr 
1               5                   10              


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#07 CDR3alpha-junction

<400>  82

Cys Val Val Tyr Val Glu Ser Gly Gly Ser Tyr Ile Pro Thr Phe 
1               5                   10                  15  


<210>  83
<211>  1833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  83
atggatacct ggctcgtctg ttgggccatc ttttctctgc tgaaagctgg cctgacagaa       60

cctgaggtta cacagacacc tagccaccag gtgactcaga tgggacagga agtgatcctg      120

agatgtgtgc ccatcagcaa tcacctgtac ttttattggt acaggcagat tctgggccag      180

aaggtcgaat tcctggtgag cttttacaat aacgagatta gcgagaaatc cgaaatcttc      240

gacgatcagt tctcagtgga gagacctgat ggcagcaatt ttaccctgaa gattcgcagc      300

acaaagctgg aggatagcgc catgtacttt tgtgcgagtt ctagacgagg cgggcctatt      360

gaaacccagt attttggccc tggaacaaga ctgctggtcc ttgaggacct gaagaacgtg      420

ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa      480

gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg      540

gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag      600

cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc      660

tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac      720

gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg      780

ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc      840

atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg      900

gtgctgatgg ccatggtcaa gcggaaggac agccggggcg gttccggagc cacgaacttc      960

tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgat gaagagcctg     1020

cgagtcctcc tggtgattct gtggctgcaa ctttcttggg tgtggtctca gcagaaagaa     1080

gtggagcagg atcctggacc tctgtctgtg cctgaaggag ctattgtgag cctcaattgt     1140

acttacagca atagcgcctt ccagtacttc atgtggtacc ggcagtacag caggaagggc     1200

cctgaactgc tcatgtatac ctattctagc ggcaataagg aggatggcag gtttacagcc     1260

caggtggaca agagctccaa gtatataagt ttattcatca gagatagcca gcctagcgat     1320

tctgccacct acctgtgtgc catgtctgcc gacaatgcag gtaatatgct gacatttgga     1380

ggcggaacaa ggctgatggt gaaaccccac atccagaacc ccgaccccgc tgtgtaccag     1440

ctgcgggaca gcaagagcag cgacaagagc gtgtgcctgt tcaccgactt cgacagccag     1500

accaacgtgt cccagagcaa ggacagcgac gtgtacatca ccgataagtg cgtgctggac     1560

atgcggagca tggacttcaa gagcaacagc gccgtggcct ggtccaacaa gagcgacttc     1620

gcctgcgcca acgccttcaa caacagcatt atccccgagg acacattctt cccaagcccc     1680

gagagcagct gcgacgtgaa gctggtggaa aagagcttcg agacagacac caacctgaac     1740

ttccagaacc tcagcgtgat cggcttccgg atcctgctgc tgaaggtggc cggcttcaac     1800

ctgctgatga ccctgcggct gtggtccagc tga                                  1833


<210>  84
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 TCRbeta-P2A-TCRalpha

<400>  84

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Arg Arg Gly Gly Pro Ile Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
            340                 345                 350         


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu 
        355                 360                 365             


Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn 
    370                 375                 380                 


Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly 
385                 390                 395                 400 


Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly 
                405                 410                 415     


Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe 
            420                 425                 430         


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Met 
        435                 440                 445             


Ser Ala Asp Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg 
    450                 455                 460                 


Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
            500                 505                 510         


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
        515                 520                 525             


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
    530                 535                 540                 


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
545                 550                 555                 560 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
                565                 570                 575     


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
            580                 585                 590         


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
        595                 600                 605             


Ser Ser 
    610 



<210>  85
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 TCRVbeta

<400>  85

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Arg 
                85                  90                  95      


Arg Gly Gly Pro Ile Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Leu Val Leu Glu 
        115     


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CDR1beta

<400>  86

Ser Asn His Leu Tyr 
1               5   


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CDR2beta

<400>  87

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  88
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CR3beta

<400>  88

Ala Ser Ser Arg Arg Gly Gly Pro Ile Glu Thr Gln Tyr 
1               5                   10              


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CR3beta-junction

<400>  89

Cys Ala Ser Ser Arg Arg Gly Gly Pro Ile Glu Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  90
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 TCRValpha

<400>  90

Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln Tyr 
            20                  25                  30          


Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu Met 
        35                  40                  45              


Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Met Ser Ala Asp Asn Ala 
                85                  90                  95      


Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met Val Lys Pro 
            100                 105                 110         


His 
    

<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CDR1alpha

<400>  91

Asn Ser Ala Phe Gln Tyr 
1               5       


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CDR2alpha

<400>  92

Thr Tyr Ser Ser Gly Asn 
1               5       


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CDR3alpha

<400>  93

Ala Met Ser Ala Asp Asn Ala Gly Asn Met Leu Thr 
1               5                   10          


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#09 CDR3alpha-junction

<400>  94

Cys Ala Met Ser Ala Asp Asn Ala Gly Asn Met Leu Thr Phe 
1               5                   10                  


<210>  95
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  95
atgaccattc gactgctgtg ctacatgggc ttctacttcc tgggagctgg actgatggaa       60

gccgacatct accaaacacc cagatacctg gtgatcggaa caggcaagaa gatcaccctg      120

gagtgtagcc agacaatggg acacgacaag atgtactggt accagcagga tcctggaatg      180

gaactgcacc tgatccacta cagctatggc gtgaacagca cagagaaagg cgatctgagc      240

agcgagtcta cagtgagcag aatcagaacc gagcacttcc ctctgacact ggaatctgct      300

agacctagcc acacaagcca gtacctgtgt gctagctcta gaggacctga ggcctttttt      360

ggacagggaa caagactgac agtggtggag gatctgaaca aggtgttccc cccagaggtg      420

gccgtgttcg agccttctga ggccgagatc tcccacaccc agaaagccac cctcgtgtgc      480

ctggccaccg gctttttccc cgaccacgtg gaactgtctt ggtgggtcaa cggcaaagag      540

gtgcactccg gcgtgtgcac cgatccccag cctctgaaag aacagcccgc cctgaacgac      600

agccggtact gcctgagcag cagactgaga gtgtccgcca ccttctggca gaacccccgg      660

aaccacttca gatgccaggt gcagttctac ggcctgagcg agaacgacga gtggacccag      720

gacagagcca agcccgtgac acagatcgtg tctgccgaag cctggggcag agccgattgc      780

ggctttacct ccgtgtccta tcagcagggc gtgctgagcg ccacaatcct gtacgagatc      840

ctgctgggca aggccaccct gtacgccgtg ctggtgtctg ccctggtgct gatggccatg      900

gtcaagcgga aggacttcgg ttccggagcc acgaacttct ctctgttaaa gcaagcagga      960

gacgtggaag aaaaccccgg tcccatgaag acctttgccg gattctcatt cctatttctc     1020

tggctgcagc tggattgtat gagcagaggc gaagatgtgg aacagagcct gtttctgagc     1080

gtgagagagg gcgatagctc tgtgatcaat tgcacataca cggatagcag cagcacctac     1140

ctgtactggt ataaacagga gccgggcgcg ggcctgcaac tgctgacata catcttcagc     1200

aatatggata tgaagcagga ccagaggttg accgtcttac tcaataagaa agacaagcac     1260

ctgtctctga gaatcgctga cactcagact ggcgatagcg ccatctactt ctgtgctgga     1320

cctcttggcg gatctcaggg aaatcttatc ttcggtaagg gcacaaagct gagcgtgaag     1380

cccaatatac aaaacccaga ccccgccgtg taccagctgc gggacagcaa gagcagcgac     1440

aagagcgtgt gcctgttcac cgacttcgac agccagacca acgtgtccca gagcaaggac     1500

agcgacgtgt acatcaccga taagtgcgtg ctggacatgc ggagcatgga cttcaagagc     1560

aacagcgccg tggcctggtc caacaagagc gacttcgcct gcgccaacgc cttcaacaac     1620

agcattatcc ccgaggacac attcttccca agccccgaga gcagctgcga cgtgaagctg     1680

gtggaaaaga gcttcgagac agacaccaac ctgaacttcc agaacctcag cgtgatcggc     1740

ttccggatcc tgctgctgaa ggtggccggc ttcaacctgc tgatgaccct gcggctgtgg     1800

tccagctga                                                             1809


<210>  96
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 TCRbeta-P2A-TCRalpha

<400>  96

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Gly Pro Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
    130                 135                 140                 


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu 
            180                 185                 190         


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
225                 230                 235                 240 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
305                 310                 315                 320 


Asp Val Glu Glu Asn Pro Gly Pro Met Lys Thr Phe Ala Gly Phe Ser 
                325                 330                 335     


Phe Leu Phe Leu Trp Leu Gln Leu Asp Cys Met Ser Arg Gly Glu Asp 
            340                 345                 350         


Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser Ser Val 
        355                 360                 365             


Ile Asn Cys Thr Tyr Thr Asp Ser Ser Ser Thr Tyr Leu Tyr Trp Tyr 
    370                 375                 380                 


Lys Gln Glu Pro Gly Ala Gly Leu Gln Leu Leu Thr Tyr Ile Phe Ser 
385                 390                 395                 400 


Asn Met Asp Met Lys Gln Asp Gln Arg Leu Thr Val Leu Leu Asn Lys 
                405                 410                 415     


Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr Gly Asp 
            420                 425                 430         


Ser Ala Ile Tyr Phe Cys Ala Gly Pro Leu Gly Gly Ser Gln Gly Asn 
        435                 440                 445             


Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro Asn Ile Gln 
    450                 455                 460                 


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
465                 470                 475                 480 


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
                485                 490                 495     


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
        515                 520                 525             


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
    530                 535                 540                 


Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu 
545                 550                 555                 560 


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  97
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 TCRVbeta

<400>  97

Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile Gly Thr Gly 
1               5                   10                  15      


Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His Asp Lys Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu Ile His Tyr 
        35                  40                  45              


Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser Ser Glu Ser 
    50                  55                  60                  


Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr Leu Glu Ser 
65                  70                  75                  80  


Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser Ser Arg Gly 
                85                  90                  95      


Pro Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu 
            100                 105                 110     


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR1beta

<400>  98

Met Gly His Asp Lys 
1               5   


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR2beta

<400>  99

Ser Tyr Gly Val Asn Ser 
1               5       


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR3beta

<400>  100

Ala Ser Ser Arg Gly Pro Glu Ala Phe 
1               5                   


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR3beta-junction

<400>  101

Cys Ala Ser Ser Arg Gly Pro Glu Ala Phe Phe 
1               5                   10      


<210>  102
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 TCRValpha

<400>  102

Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp 
1               5                   10                  15      


Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser Ser Ser Thr Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu Gln Leu Leu Thr Tyr 
        35                  40                  45              


Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln Arg Leu Thr Val Leu 
    50                  55                  60                  


Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln 
65                  70                  75                  80  


Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Gly Pro Leu Gly Gly Ser 
                85                  90                  95      


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
            100                 105                 110         


Asn 
    

<210>  103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR1alpha

<400>  103

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR2alpha

<400>  104

Ile Phe Ser Asn Met Asp Met 
1               5           


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR3alpha

<400>  105

Ala Gly Pro Leu Gly Gly Ser Gln Gly Asn Leu Ile 
1               5                   10          


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#10 CDR3alpha-junction

<400>  106

Cys Ala Gly Pro Leu Gly Gly Ser Gln Gly Asn Leu Ile Phe 
1               5                   10                  


<210>  107
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  107
atgggacctc agcttcttgg atacgttgtg ctgtgtctgc ttggagccgg acctttagag       60

gctcaggtta cccagaaccc cagatacctg attacagtga caggcaagaa gctgaccgtg      120

acctgtagcc agaacatgaa ccacgagtac atgagctggt acagacagga tcctggactg      180

ggactccggc aaatttacta cagcatgaac gtggaggtga ccgataaagg agatgtgccc      240

gaaggctaca aggtgagcag gaaggagaag aggaatttcc ccctgatcct ggaatctcct      300

agccctaatc agaccagcct gtacttctgt gccagcagcc caaggtctcc cgaaggagga      360

agagcctaca atgagcagtt ctttggccct ggaacaagac tgaccgtgct ggaagacctg      420

aagaacgtgt tccccccaga ggtggccgtg ttcgagccta gcgaggccga gatcagccac      480

acccagaaag ccaccctcgt gtgcctggcc accggctttt accccgacca cgtggaactg      540

tcttggtggg tcaacggcaa agaggtgcac agcggcgtct gcaccgaccc ccagcccctg      600

aaagagcagc ccgccctgaa cgacagccgg tactgtctga gcagcagact gagagtgtcc      660

gccaccttct ggcagaaccc ccggaaccac ttcagatgcc aggtgcagtt ctacggcctg      720

agcgagaacg acgagtggac ccaggaccgg gccaagcccg tgacccagat cgtgtctgct      780

gaggcctggg gcagagccga ttgcggcttc accagcgaga gctaccagca gggcgtgctg      840

agcgccacca tcctgtacga gatcctgctg ggcaaggcca ccctgtacgc cgtgctggtg      900

tccgccctgg tgctgatggc catggtcaag cggaaggaca gccggggcgg ttccggagcc      960

acgaacttct ctctgttaaa gcaagcagga gacgtggaag aaaaccccgg tcccatggag     1020

aagatgctgg agtgtgcgtt catcgttctg tggctgcaac ttggatggct gtctggagag     1080

gatcaggtta cacagtctcc tgaagccctg agactgcaag aaggagagag ctcatcgttg     1140

aactgcagct acacagtgtc tggactgaga ggcctgttct ggtataggca ggatccgggc     1200

aaaggacctg agttcctgtt taccctctat tcagctgggg aggagaagga gaaggagaga     1260

ctgaaggcta cactgaccaa gaaggagagc tttcttcaca ttactgcccc caaacctgag     1320

gattctgcca catacctgtg tgctgctctg gacagagaca attatggcca aaatttcgtg     1380

tttggccctg gaaccagact gtctgtgctg ccttacattc agaaccccga tcctgccgtg     1440

taccagctgc gggacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac     1500

agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg     1560

ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc     1620

gacttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca     1680

agccccgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac     1740

ctgaacttcc agaacctcag cgtgatcggc ttccggatcc tgctgctgaa ggtggccggc     1800

ttcaacctgc tgatgaccct gcggctgtgg tccagctga                            1839


<210>  108
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 TCRbeta-P2A-TCRalpha

<400>  108

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Arg Ser Pro Glu Gly Gly Arg Ala Tyr Asn Glu Gln Phe Phe 
        115                 120                 125             


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe 
    130                 135                 140                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
145                 150                 155                 160 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp 
                165                 170                 175     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            180                 185                 190         


Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        195                 200                 205             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
225                 230                 235                 240 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                245                 250                 255     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            260                 265                 270         


Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    290                 295                 300                 


Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala 
305                 310                 315                 320 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                325                 330                 335     


Gly Pro Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu 
            340                 345                 350         


Gln Leu Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu 
        355                 360                 365             


Ala Leu Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr 
    370                 375                 380                 


Thr Val Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly 
385                 390                 395                 400 


Lys Gly Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys 
                405                 410                 415     


Glu Lys Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu 
            420                 425                 430         


His Ile Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala 
        435                 440                 445             


Ala Leu Asp Arg Asp Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly 
    450                 455                 460                 


Thr Arg Leu Ser Val Leu Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val 
465                 470                 475                 480 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
                485                 490                 495     


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
            500                 505                 510         


Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe 
        515                 520                 525             


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
    530                 535                 540                 


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
545                 550                 555                 560 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
                565                 570                 575     


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
            580                 585                 590         


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
        595                 600                 605             


Leu Trp Ser Ser 
    610         



<210>  109
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 TCRVbeta

<400>  109

Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly 
1               5                   10                  15      


Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr 
        35                  40                  45              


Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr 
    50                  55                  60                  


Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser 
65                  70                  75                  80  


Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Pro Arg 
                85                  90                  95      


Ser Pro Glu Gly Gly Arg Ala Tyr Asn Glu Gln Phe Phe Gly Pro Gly 
            100                 105                 110         


Thr Arg Leu Thr Val Leu Glu 
        115                 


<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR1beta

<400>  110

Met Asn His Glu Tyr 
1               5   


<210>  111
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR2beta

<400>  111

Ser Met Asn Val Glu Val 
1               5       


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR3beta

<400>  112

Ala Ser Ser Pro Arg Ser Pro Glu Gly Gly Arg Ala Tyr Asn Glu Gln 
1               5                   10                  15      


Phe 
    

<210>  113
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR3beta-junction

<400>  113

Cys Ala Ser Ser Pro Arg Ser Pro Glu Gly Gly Arg Ala Tyr Asn Glu 
1               5                   10                  15      


Gln Phe Phe 
            

<210>  114
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 TCRValpha

<400>  114

Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu Arg Leu Gln Glu Gly 
1               5                   10                  15      


Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val Ser Gly Leu Arg Gly 
            20                  25                  30          


Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly Pro Glu Phe Leu Phe 
        35                  40                  45              


Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys Glu Arg Leu Lys Ala 
    50                  55                  60                  


Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile Thr Ala Pro Lys Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Leu Cys Ala Ala Leu Asp Arg Asp Asn Tyr 
                85                  90                  95      


Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu Pro 
            100                 105                 110         


Tyr 
    
<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR1alpha

<400>  115

Val Ser Gly Leu Arg Gly 
1               5       


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR2alpha

<400>  116

Leu Tyr Ser Ala Gly Glu Glu 
1               5           


<210>  117
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR3alpha

<400>  117

Ala Ala Leu Asp Arg Asp Asn Tyr Gly Gln Asn Phe Val 
1               5                   10              


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#11 CDR3alpha-junction

<400>  118

Cys Ala Ala Leu Asp Arg Asp Asn Tyr Gly Gln Asn Phe Val Phe 
1               5                   10                  15  


<210>  119
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  119
atgaccattc gactgctgtg ctacatgggc ttctacttcc tgggagctgg actgatggaa       60

gccgacatct accaaacacc cagatacctg gtgatcggaa caggcaagaa gatcaccctg      120

gagtgtagcc agacaatggg acacgacaag atgtactggt accagcagga tcctggaatg      180

gaactgcacc tgatccacta cagctatggc gtgaacagca cagagaaagg cgatctgagc      240

agcgagtcta cagtgagcag aatcagaacc gagcacttcc ctctgacact ggaatctgct      300

agacctagcc acacaagcca gtacctgtgt gcttctagcg agaacagcaa tcagccccag      360

catttcggcg atggcacccg cttgtccatc ttggaggatc tgaacaaggt gttcccccca      420

gaggtggccg tgttcgagcc ttctgaggcc gagatctccc acacccagaa agccaccctc      480

gtgtgcctgg ccaccggctt tttccccgac cacgtggaac tgtcttggtg ggtcaacggc      540

aaagaggtgc actccggcgt gtgcaccgat ccccagcctc tgaaagaaca gcccgccctg      600

aacgacagcc ggtactgcct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac      660

ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg      720

acccaggaca gagccaagcc cgtgacacag atcgtgtctg ccgaagcctg gggcagagcc      780

gattgcggct ttacctccgt gtcctatcag cagggcgtgc tgagcgccac aatcctgtac      840

gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtctgccct ggtgctgatg      900

gccatggtca agcggaagga cttcggttcc ggagccacga acttctctct gttaaagcaa      960

gcaggagacg tggaagaaaa ccccggtccc atgaccagca ttagagccgt gttcatcttc     1020

ctgtggctgc agctggatct ggtgaatggc gagaatgtgg aacagcatcc tagcacactg     1080

tctgttcagg agggcgattc tgccgtgatc aagtgcacct atagcgattc tgccagcaac     1140

tacttccctt ggtacaagca ggagctgggc aaaggacctc agctgatcat cgacatcagg     1200

agcaatgtgg gagagaagaa ggatcagaga atcgccgtga cattaaataa gaccgccaag     1260

cactttagcc tgcacatcac agagacacaa cctgaggatt ctgccgtgta cttttgtgcc     1320

gcccctaacg acatgagatt cggcgccggg acacgtctga cagtgaagcc caacatccaa     1380

aatcctgatc ccgccgtgta ccagctgcgg gacagcaaga gcagcgacaa gagcgtgtgc     1440

ctgttcaccg acttcgacag ccagaccaac gtgtcccaga gcaaggacag cgacgtgtac     1500

atcaccgata agtgcgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg     1560

gcctggtcca acaagagcga cttcgcctgc gccaacgcct tcaacaacag cattatcccc     1620

gaggacacat tcttcccaag ccccgagagc agctgcgacg tgaagctggt ggaaaagagc     1680

ttcgagacag acaccaacct gaacttccag aacctcagcg tgatcggctt ccggatcctg     1740

ctgctgaagg tggccggctt caacctgctg atgaccctgc ggctgtggtc cagctga        1797


<210>  120
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 TCRbeta-P2A-TCRalpha

<400>  120

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Glu Asn Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu 
        115                 120                 125             


Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
305                 310                 315                 320 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Thr Ser Ile Arg Ala 
                325                 330                 335     


Val Phe Ile Phe Leu Trp Leu Gln Leu Asp Leu Val Asn Gly Glu Asn 
            340                 345                 350         


Val Glu Gln His Pro Ser Thr Leu Ser Val Gln Glu Gly Asp Ser Ala 
        355                 360                 365             


Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala Ser Asn Tyr Phe Pro Trp 
    370                 375                 380                 


Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln Leu Ile Ile Asp Ile Arg 
385                 390                 395                 400 


Ser Asn Val Gly Glu Lys Lys Asp Gln Arg Ile Ala Val Thr Leu Asn 
                405                 410                 415     


Lys Thr Ala Lys His Phe Ser Leu His Ile Thr Glu Thr Gln Pro Glu 
            420                 425                 430         


Asp Ser Ala Val Tyr Phe Cys Ala Ala Pro Asn Asp Met Arg Phe Gly 
        435                 440                 445             


Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro 
    450                 455                 460                 


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
465                 470                 475                 480 


Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp 
                485                 490                 495     


Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met 
            500                 505                 510         


Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe 
        515                 520                 525             


Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe 
    530                 535                 540                 


Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
                565                 570                 575     


Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             



<210>  121
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 TCRVbeta

<400>  121

Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile Gly Thr Gly 
1               5                   10                  15      


Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His Asp Lys Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu Ile His Tyr 
        35                  40                  45              


Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser Ser Glu Ser 
    50                  55                  60                  


Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr Leu Glu Ser 
65                  70                  75                  80  


Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser Ser Glu Asn 
                85                  90                  95      


Ser Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            100                 105                 110         


Glu 
    

<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR1beta

<400>  122

Met Gly His Asp Lys 
1               5   


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR2beta

<400>  123

Ser Tyr Gly Val Asn Ser 
1               5       


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR3beta

<400>  124

Ala Ser Ser Glu Asn Ser Asn Gln Pro Gln His 
1               5                   10      


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR3beta-junction

<400>  125

Cys Ala Ser Ser Glu Asn Ser Asn Gln Pro Gln His Phe 
1               5                   10              


<210>  126
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 TCRValpha

<400>  126

Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala Ser Asn Tyr 
            20                  25                  30          


Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln Leu Ile Ile 
        35                  40                  45              


Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg Ile Ala Val 
    50                  55                  60                  


Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile Thr Glu Thr 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Pro Asn Asp Met 
                85                  90                  95      


Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn 
            100                 105                 


<210>  127
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR1alpha

<400>  127

Asp Ser Ala Ser Asn Tyr 
1               5       


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR2alpha

<400>  128

Ile Arg Ser Asn Val Gly Glu 
1               5           


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR3alpha

<400>  129

Ala Ala Pro Asn Asp Met Arg 
1               5           


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#13 CDR3alpha-junction

<400>  130

Cys Ala Ala Pro Asn Asp Met Arg Phe 
1               5                   


<210>  131
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  131
atgggcacat ctcttctctg ttgggttgtg ctgggctttc tgggcacaga tcatacagga       60

gctggagtta gccagtctcc taggtataag gtgaccaaga ggggacagga tgtggctctg      120

agatgtgacc ctatttctgg ccacgtgagc ctttactggt acagacaagc tctgggacaa      180

ggacccgagt ttctgaccta cttcaactac gaggcccagc aggataaatc tggactgccc      240

aacgacagat tcagcgccga aagacctgaa ggctctatca gcacactgac cattcagaga      300

acagagcaga gggattctgc catgtacaga tgcgccagct ctctttgggg aagagccgtt      360

gatgagcagt tttttggccc tggaaccaga ctgacagttc tggaggacct gaagaacgtg      420

ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa      480

gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg      540

gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag      600

cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc      660

tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac      720

gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg      780

ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc      840

atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg      900

gtgctgatgg ccatggtcaa gcggaaggac agccggggcg gttccggagc cacgaacttc      960

tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgaa ctactctcct     1020

ggccttgtca gcctgattct gctgctgctg ggaagaacaa gaggcgatag cgttacacag     1080

atggaaggac ctgtgacact gtctgaagag gccttcctga ccatcaattg cacctacaca     1140

gccactggtt acccgtccct tttctggtat gtgcagtacc ctggagaggg actgcaactg     1200

ctgttaaagg ccacaaaagc cgacgataag ggcagcaata agggctttga ggccacctac     1260

aggaaggaga caaccagctt tcatctggag aagggaagcg tgcaagtgtc tgattcagcc     1320

gtgtactttt gtgccctgct gggctctaat gactacaagc tgagctttgg agccggcaca     1380

acagtgaccg ttagagccaa tatccaaaac cccgacccag ctgtgtacca gctgcgggac     1440

agcaagagca gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg     1500

tcccagagca aggacagcga cgtgtacatc accgataagt gcgtgctgga catgcggagc     1560

atggacttca agagcaacag cgccgtggcc tggtccaaca agagcgactt cgcctgcgcc     1620

aacgccttca acaacagcat tatccccgag gacacattct tcccaagccc cgagagcagc     1680

tgcgacgtga agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac     1740

ctcagcgtga tcggcttccg gatcctgctg ctgaaggtgg ccggcttcaa cctgctgatg     1800

accctgcggc tgtggtccag ctga                                            1824


<210>  132
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 TCRbeta-P2A-TCRalpha

<400>  132

Met Gly Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala 
            100                 105                 110         


Ser Ser Leu Trp Gly Arg Ala Val Asp Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly Arg 
            340                 345                 350         


Thr Arg Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu Ser 
        355                 360                 365             


Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly Tyr 
    370                 375                 380                 


Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln Leu 
385                 390                 395                 400 


Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly Phe 
                405                 410                 415     


Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys Gly 
            420                 425                 430         


Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Leu Gly 
        435                 440                 445             


Ser Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val 
    450                 455                 460                 


Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
465                 470                 475                 480 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
                485                 490                 495     


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
            500                 505                 510         


Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
        515                 520                 525             


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
    530                 535                 540                 


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
545                 550                 555                 560 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
                565                 570                 575     


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
            580                 585                 590         


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605         


<210>  133
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 TCRVbeta

<400>  133

Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His Val Ser Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro Asn Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu Thr Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala Ser Ser Leu 
                85                  90                  95      


Trp Gly Arg Ala Val Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu 
        115     


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR1beta

<400>  134

Ser Gly His Val Ser 
1               5   


<210>  135
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR2beta

<400>  135

Phe Asn Tyr Glu Ala Gln 
1               5       


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR3beta

<400>  136

Ala Ser Ser Leu Trp Gly Arg Ala Val Asp Glu Gln Phe 
1               5                   10              


<210>  137
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CR3beta-junction

<400>  137

Cys Ala Ser Ser Leu Trp Gly Arg Ala Val Asp Glu Gln Phe Phe 
1               5                   10                  15  


<210>  138
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 TCRValpha

<400>  138

Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu Ser Glu Glu 
1               5                   10                  15      


Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly Tyr Pro Ser 
            20                  25                  30          


Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln Leu Leu Leu 
        35                  40                  45              


Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly Phe Glu Ala 
    50                  55                  60                  


Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys Gly Ser Val 
65                  70                  75                  80  


Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Leu Gly Ser Asn 
                85                  90                  95      


Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala 
            100                 105                 110         


Asn 
    

<210>  139
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR1alpha

<400>  139

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR2alpha

<400>  140

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR3alpha

<400>  141

Ala Leu Leu Gly Ser Asn Asp Tyr Lys Leu Ser 
1               5                   10      


<210>  142
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#15 CDR3alpha-junction

<400>  142

Cys Ala Leu Leu Gly Ser Asn Asp Tyr Lys Leu Ser Phe 
1               5                   10              


<210>  143
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 TCRbeta-P2A-TCRalpha, 
       codon-optimized nucleotide

<400>  143
atgtctatcg gtctgctgtg ctgtgtagca ttcagtctac tttgggcttc tcccgtgaat       60

gctggagtta cacaaacccc caagttccag gtgttaaaga ccggccagag catgacactg      120

cagtgtgctc aggacatgaa tcacaacagt atgtattggt acagacagga tcccggcatg      180

ggactgagac tgatctacta cagcgcttct gagggaacta cagacaaagg agaggtgccc      240

aacggctaca acgtgagcag gctgaacaag agggagttta gcctgagact ggaatccgct      300

gccccgtctc agacaagcgt gtacttctgc gcctcttctg agggatacgg ctatgagcag      360

tattttggcc ctggcacaag actgacagtg acagaggacc tgaagaacgt gttcccccca      420

gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc      480

gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc      540

aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg      600

aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac      660

ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg      720

acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc      780

gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac      840

gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg      900

gccatggtca agcggaagga cagccggggc ggttccggag ccacgaactt ctctctgtta      960

aagcaagcag gagacgtgga agaaaacccc ggtcccatgc tgctggaaca cctactgatc     1020

atcctgtgga tgcagctgac atgggtgtct ggacagcagc tgaatcagtc tcctcagagc     1080

atgttcattc aggagggaga ggatgtgagc atgaactgca catcgtccag catcttcaac     1140

acctggctgt ggtataagca ggatcctgga gaaggacctg tgctgctgat tgccctgtat     1200

aaagccggag agctgacctc taatggaaga ctgacagccc agtttggcat caccagaaag     1260

gacagcttcc tgaacatctc cgcatccatt ccttctgatg tgggcatcta cttctgtgcc     1320

ggccacatta cacaaggcgg atctgagaag ctggtgtttg gcaaaggcac caagctgaca     1380

gttaacccct acatccagaa tcccgatcct gccgtgtacc agctgcggga cagcaagagc     1440

agcgacaaga gcgtgtgcct gttcaccgac ttcgacagcc agaccaacgt gtcccagagc     1500

aaggacagcg acgtgtacat caccgataag tgcgtgctgg acatgcggag catggacttc     1560

aagagcaaca gcgccgtggc ctggtccaac aagagcgact tcgcctgcgc caacgccttc     1620

aacaacagca ttatccccga ggacacattc ttcccaagcc ccgagagcag ctgcgacgtg     1680

aagctggtgg aaaagagctt cgagacagac accaacctga acttccagaa cctcagcgtg     1740

atcggcttcc ggatcctgct gctgaaggtg gccggcttca acctgctgat gaccctgcgg     1800

ctgtggtcca gctga                                                      1815


<210>  144
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 TCRbeta-P2A-TCRalpha

<400>  144

Met Ser Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Gly Tyr Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Glu 
                325                 330                 335     


His Leu Leu Ile Ile Leu Trp Met Gln Leu Thr Trp Val Ser Gly Gln 
            340                 345                 350         


Gln Leu Asn Gln Ser Pro Gln Ser Met Phe Ile Gln Glu Gly Glu Asp 
        355                 360                 365             


Val Ser Met Asn Cys Thr Ser Ser Ser Ile Phe Asn Thr Trp Leu Trp 
    370                 375                 380                 


Tyr Lys Gln Asp Pro Gly Glu Gly Pro Val Leu Leu Ile Ala Leu Tyr 
385                 390                 395                 400 


Lys Ala Gly Glu Leu Thr Ser Asn Gly Arg Leu Thr Ala Gln Phe Gly 
                405                 410                 415     


Ile Thr Arg Lys Asp Ser Phe Leu Asn Ile Ser Ala Ser Ile Pro Ser 
            420                 425                 430         


Asp Val Gly Ile Tyr Phe Cys Ala Gly His Ile Thr Gln Gly Gly Ser 
        435                 440                 445             


Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn Pro Tyr 
    450                 455                 460                 


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
465                 470                 475                 480 


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
                485                 490                 495     


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
            500                 505                 510         


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
        515                 520                 525             


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
    530                 535                 540                 


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
545                 550                 555                 560 


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
                565                 570                 575     


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
            580                 585                 590         


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 


<210>  145
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 TCRVbeta

<400>  145

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Asn Ser Met 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile Tyr Tyr 
        35                  40                  45              


Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg Leu Glu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Glu Gly 
                85                  90                  95      


Tyr Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


Glu 
    


<210>  146
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR1beta

<400>  146

Met Asn His Asn Ser 
1               5   


<210>  147
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR2beta

<400>  147

Ser Ala Ser Glu Gly Thr 
1               5       


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR3beta

<400>  148

Ala Ser Ser Glu Gly Tyr Gly Tyr Glu Gln Tyr 
1               5                   10      


<210>  149
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR3beta-junction

<400>  149

Cys Ala Ser Ser Glu Gly Tyr Gly Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  150
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 TCRValpha

<400>  150

Gly Gln Gln Leu Asn Gln Ser Pro Gln Ser Met Phe Ile Gln Glu Gly 
1               5                   10                  15      


Glu Asp Val Ser Met Asn Cys Thr Ser Ser Ser Ile Phe Asn Thr Trp 
            20                  25                  30          


Leu Trp Tyr Lys Gln Asp Pro Gly Glu Gly Pro Val Leu Leu Ile Ala 
        35                  40                  45              


Leu Tyr Lys Ala Gly Glu Leu Thr Ser Asn Gly Arg Leu Thr Ala Gln 
    50                  55                  60                  


Phe Gly Ile Thr Arg Lys Asp Ser Phe Leu Asn Ile Ser Ala Ser Ile 
65                  70                  75                  80  


Pro Ser Asp Val Gly Ile Tyr Phe Cys Ala Gly His Ile Thr Gln Gly 
                85                  90                  95      


Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys Leu Thr Val Asn 
            100                 105                 110         


Pro Tyr 
        


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR1alpha

<400>  151

Ser Ile Phe Asn Thr 
1               5   


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR2alpha

<400>  152

Leu Tyr Lys Ala Gly Glu Leu 
1               5           


<210>  153
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR3alpha

<400>  153

Ala Gly His Ile Thr Gln Gly Gly Ser Glu Lys Leu Val 
1               5                   10              


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SOX2 TCR#16 CDR3alpha-junction

<400>  154

Cys Ala Gly His Ile Thr Gln Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10                  15  

<210>  155
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic TCR Calpha1

<400>  155

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  156
<211>  178
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic TCR Cbeta2

<400>  156

Asp Leu Lys Asn Val Phe Pro Pro Lys Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  157
<211>  176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic TCR beta1

<400>  157

Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  158
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic CD8 co-receptor alpha chain, without signal sequence

<400>  158

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                165                 170                 175     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
            180                 185                 190         


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
        195                 200                 205             


Leu Ser Ala Arg Tyr Val 
    210                 


<210>  159
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic CD8 co-receptor beta chain isoform 1, without signal 
       sequence

<400>  159

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
            180                 185                 


<210>  160
<211>  200
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic CD8 co-receptor beta chain isoform 2, without signal 
       sequence

<400>  160

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Leu Arg Leu His Pro Leu 
            180                 185                 190         


Glu Lys Cys Ser Arg Met Asp Tyr 
        195                 200 


<210>  161
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic CD8 co-receptor beta chain isoform 3, without signal 
       sequence

<400>  161

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Lys Phe Asn Ile Val Cys 
            180                 185                 190         


Leu Lys Ile Ser Gly Phe Thr Thr Cys Cys Cys Phe Gln Ile Leu Gln 
        195                 200                 205             


Ile Ser Arg Glu Tyr Gly Phe Gly Val Leu Leu Gln Lys Asp Ile Gly 
    210                 215                 220                 


Gln 
225 


<210>  162
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic CD8 co-receptor beta chain isoform 4, without signal 
       sequence

<400>  162

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Lys Phe Asn Ile Val Cys 
            180                 185                 190         


Leu Lys Ile Ser Gly Phe Thr Thr Cys Cys Cys Phe Gln Ile Leu Gln 
        195                 200                 205             


Ile Ser Arg Glu Tyr Gly Phe Gly Val Leu Leu Gln Lys Asp Ile Gly 
    210                 215                 220                 


Gln 
225 


<210>  163
<211>  222
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic CD8 co-receptor beta chain isoform5, without signal 
       sequence

<400>  163

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro Gln Gly Glu Gly Ile 
            180                 185                 190         


Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly Tyr Tyr Ser Asn Thr 
        195                 200                 205             


Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile Leu Lys Thr 
    210                 215                 220         



