                         SEQUENCE LISTING

<110>  Feinstein, Paul
       DHulst, Charlotte
 
<120>  BIOSENSORS FOR DETECTING CHANGES IN THE LEVEL OF A 
       NEUROTRANSMITTER IN THE CENTRAL NERVOUS SYSTEM

<130>  342509.46076

<150>  US 63/081,871
<151>  2020-09-22

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  319
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Met Asp Arg Ser Asn Glu Thr Ser Leu Val Ser Tyr Phe Ile Leu Leu 
1               5                   10                  15      


Gly Leu Ser Ala His Pro Arg Leu Glu Lys Thr Phe Phe Val Leu Ile 
            20                  25                  30          


Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 
        35                  40                  45              


Val Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro 
65                  70                  75                  80  


Leu Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser 
                85                  90                  95      


Gly Cys Ala Met Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 
            100                 105                 110         


Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 
    130                 135                 140                 


Met Ala Ala Gly Ser Trp Ala Gly Gly Ser Ile Thr Ala Thr Val Gln 
145                 150                 155                 160 


Thr Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 
                165                 170                 175     


His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 
            180                 185                 190         


Ile Ser Ile Asn Val Ile Ser Met Ala Val Gly Asn Ala Val Phe Leu 
        195                 200                 205             


Gly Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser 
    210                 215                 220                 


Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile 
                245                 250                 255     


Leu Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp 
            260                 265                 270         


Lys Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Leu 
        275                 280                 285             


Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 
    290                 295                 300                 


Arg Ala Ala Val Arg Asn Leu Leu His Gln Lys His Phe Lys Trp 
305                 310                 315                 


<210>  2
<211>  315
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Glu Ser Ser Asn Gln Thr Ser Pro Val Ser Arg Phe Ile Leu Leu 
1               5                   10                  15      


Gly Leu Ser Ala His Pro Thr Leu Glu Lys Thr Phe Phe Val Leu Ile 
            20                  25                  30          


Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 
        35                  40                  45              


Val Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 
65                  70                  75                  80  


Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser 
                85                  90                  95      


Gly Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 
            100                 105                 110         


Cys Val Leu Leu Ser Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Val Tyr Val Pro 
    130                 135                 140                 


Met Ala Thr Gly Ser Trp Ala Ala Gly Ile Ala Ala Ser Leu Val Gln 
145                 150                 155                 160 


Thr Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 
                165                 170                 175     


His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 
            180                 185                 190         


Ile Ser Ile Asn Ile Ile Ser Met Gly Val Thr Asn Val Ile Phe Leu 
        195                 200                 205             


Gly Val Pro Val Leu Phe Ile Ser Phe Ser Tyr Ile Phe Ile Leu Ser 
    210                 215                 220                 


Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile 
                245                 250                 255     


Leu Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp 
            260                 265                 270         


Lys Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Leu 
        275                 280                 285             


Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 
    290                 295                 300                 


Arg Ala Ala Val Arg Asn Leu Val Val Leu Lys 
305                 310                 315 


<210>  3
<211>  318
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Glu Ile Ala Asn Gln Ser Thr Val Ala Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Asp His Pro Met Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Leu 
65                  70                  75                  80  


Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Met Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Met Val Gln Ile 
145                 150                 155                 160 


Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 
        195                 200                 205             


Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 
            260                 265                 270         


Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Leu Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Thr Ala Val Arg Asp Leu Val Gly Arg Lys Cys Leu Ile Gln 
305                 310                 315             


<210>  4
<211>  318
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Glu Val Ser Asn Gln Ser Thr Val Thr Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala His Pro Thr Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro Leu 
65                  70                  75                  80  


Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Met Val Gln Ile 
145                 150                 155                 160 


Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 
                165                 170                 175     


Phe Ile Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 
        195                 200                 205             


Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 
            260                 265                 270         


Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Leu Leu Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Thr Ala Val Arg Asp Leu Ala Ser His Arg Cys Leu Thr Gln 
305                 310                 315             


<210>  5
<211>  318
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Glu Val Ser Asn Gln Ser Thr Val Thr Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala His Pro Thr Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro Leu 
65                  70                  75                  80  


Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Met Val Gln Ile 
145                 150                 155                 160 


Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 
                165                 170                 175     


Phe Ile Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 
        195                 200                 205             


Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 
            260                 265                 270         


Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Leu Leu Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Thr Ala Val Arg Asp Leu Ala Ser His Arg Cys Leu Thr Gln 
305                 310                 315             


<210>  6
<211>  319
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Val Gln Gly Asn Trp Ser Ser Val Thr Val Phe Phe Phe Leu Gly 
1               5                   10                  15      


Phe Ser Gln Tyr Pro Arg Ile Glu Val Thr Ile Phe Val Leu Cys Leu 
            20                  25                  30          


Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Thr Ile Leu Ile Ser Ile 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Ala Leu Thr Pro 
65                  70                  75                  80  


Met Leu Ala Asn Phe Val Ser Gly Glu Asn Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Leu Gln Met Tyr Phe Ser Leu Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Arg Val Cys Val Gln Ile 
    130                 135                 140                 


Ala Ser Ser Ser Trp Ala Thr Gly Cys Leu Thr Ala Leu Val Glu Thr 
145                 150                 155                 160 


Gly Pro Val Ile His Leu Ser Leu Cys Gly Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Leu Leu Lys Met Ala Cys Gly Asp Thr 
            180                 185                 190         


Ala Met Val Gln Leu Ile Met Leu Val Ile Ser Ile Leu Leu Leu Pro 
        195                 200                 205             


Leu Pro Met Leu Leu Ile Cys Val Ser Tyr Ala Ser Ile Leu Ser Asn 
    210                 215                 220                 


Ile Leu Arg Ile Ser Ser Val Asp Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ala His Leu Thr Val Val Val Leu Phe Tyr Gly Thr Ala Leu 
                245                 250                 255     


Ser Met Tyr Leu Lys Pro Ser Ser Val Asn Ser Gln Glu Ile Asp Lys 
            260                 265                 270         


Phe Met Ala Leu Ile Tyr Ala Gly Leu Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Met Ala Val Lys Lys Leu 
    290                 295                 300                 


Leu Ile Arg Asn Pro Phe Ser Thr Ile Leu Thr Ser Val Leu Lys 
305                 310                 315                 


<210>  7
<211>  307
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Ala Pro Ile Asn Gln Ser Val Val Thr Met Phe Phe Leu Gln Asn 
1               5                   10                  15      


Phe Val Asp Asp Pro Trp Ile Gln Asn Val Leu Phe Cys Phe Phe Phe 
            20                  25                  30          


Ala Leu Phe Val Ala Ala Ile Ala Gly Asn Gly Leu Ile Ile Thr Val 
        35                  40                  45              


Ile His Ser Ser Ala Asn Leu His Thr Pro Met Tyr Phe Phe Leu Val 
    50                  55                  60                  


Asn Leu Ser Leu Met Asp Val Ile Cys Thr Val Thr Val Leu Pro Lys 
65                  70                  75                  80  


Val Leu Gln Ser Leu Val Ala Glu Asn Ala Ile Ser Tyr Gly Gly Cys 
                85                  90                  95      


Leu Thr Gln Met Phe Val Phe Ser Trp Val Leu Gly Ser Glu Leu Leu 
            100                 105                 110         


Leu Phe Ser Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg Pro 
        115                 120                 125             


Leu His Tyr Gly Thr Leu Met Ser Gly Arg Val Cys Ile Ala Leu Ala 
    130                 135                 140                 


Thr Phe Val Trp Phe Thr Gly Ala Leu Asn Ser Leu Val Leu Thr Cys 
145                 150                 155                 160 


Leu Val Leu Pro Leu Ser Phe Cys Gly Pro Asn Leu Ile Thr His Phe 
                165                 170                 175     


Phe Cys Glu Ile Pro Ser Val Leu Met Leu Ser Cys Ser Pro Thr Phe 
            180                 185                 190         


Ile Asn Asp Ile Met Thr Val Ile Ala Asp Met Phe Leu Thr Gly Leu 
        195                 200                 205             


Asn Phe Leu Leu Thr Met Thr Ser Tyr Gly Phe Ile Ile Ala Ser Ile 
    210                 215                 220                 


Leu Arg Ile Arg Ser Ala Glu Gly Lys Lys Arg Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Ser Ala His Leu Val Val Val Thr Leu Tyr Tyr Ser Thr Val Leu Tyr 
                245                 250                 255     


Thr Tyr Val Arg Pro Ala Leu Gly Thr Ser Gly Leu Leu Asp Lys Val 
            260                 265                 270         


Ile Ala Val Leu Tyr Thr Thr Val Thr Pro Ser Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Glu Phe Lys Thr Ser Phe Lys Lys Leu Leu 
    290                 295                 300                 


Phe Pro Asn 
305         


<210>  8
<211>  311
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Asp Ser Phe Asn Ala Thr Leu Glu Glu Arg Phe Ile Leu Val Gly 
1               5                   10                  15      


Phe Ser Asp Trp Pro Gln Leu Glu Leu Ile Leu Phe Val Phe Ile Ser 
            20                  25                  30          


Ile Val Tyr Ser Leu Thr Leu Phe Gly Asn Thr Ala Ile Ile Ala Leu 
        35                  40                  45              


Ser Arg Met Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


His Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 
65                  70                  75                  80  


Leu Leu Ile Asn Leu His Gly Leu Asp Arg Ile Ile Ser Tyr Gly Arg 
                85                  90                  95      


Cys Val Ala Gln Leu Phe Ile Ser Leu Ala Leu Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ile Met His Pro Val Leu Cys Gln Ala Leu 
    130                 135                 140                 


Ala Ile Ala Ser Trp Val Gly Gly Phe Leu Asn Ser Leu Ile Gln Thr 
145                 150                 155                 160 


Gly Leu Met Met Thr Ile Pro Leu Cys Gly Arg Arg Leu Asn His Phe 
                165                 170                 175     


Phe Cys Glu Met Pro Val Phe Leu Lys Leu Ala Cys Lys Asp Thr Gly 
            180                 185                 190         


Asp Thr Glu Ala Lys Met Phe Val Ala Arg Ala Ile Ile Leu Val Phe 
        195                 200                 205             


Pro Ala Thr Leu Ile Leu Gly Ser Tyr Gly His Ile Ala Arg Ala Val 
    210                 215                 220                 


Leu Lys Val Lys Ser Met Ala Gly Arg Arg Lys Ala Phe Gly Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Ser Ala Ile Tyr 
                245                 250                 255     


Thr Tyr Leu Gln Pro Lys Gly Ser Tyr Ser Glu Ser Asp Gly Lys Phe 
            260                 265                 270         


Val Ala Leu Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Leu Ile 
        275                 280                 285             


Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Trp Lys Val Leu 
    290                 295                 300                 


Gly Arg Ser Thr Gly Gln Glu 
305                 310     


<210>  9
<211>  305
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Met Asn Gly Thr Leu Val Thr Glu Phe Phe Ile Leu Gly Phe Ser 
1               5                   10                  15      


Glu Met Pro His Leu Arg Val Pro Leu Leu Leu Ser Phe Phe Cys Leu 
            20                  25                  30          


Tyr Met Ala Ala Ile Ser Gly Asn Leu Leu Ile Met Val Thr Ile Ser 
        35                  40                  45              


Ala Ser Pro Ala Leu His Thr Pro Met Tyr Phe Phe Leu Val Asn Leu 
    50                  55                  60                  


Ala Met Val Asp Ile Leu Cys Thr Ser Thr Ile Leu Pro Lys Leu Leu 
65                  70                  75                  80  


Asp Ser Met Met Ala Gly Arg Ser Ile Ser Tyr Gly Gly Cys Met Ala 
                85                  90                  95      


Gln Leu Phe Phe Phe Thr Trp Ser Leu Gly Ala Glu Leu Leu Leu Phe 
            100                 105                 110         


Ser Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Cys Pro Leu His 
        115                 120                 125             


Tyr Ser Ala Trp Met Gly Pro Arg Val Cys Ala Phe Leu Ala Gly Leu 
    130                 135                 140                 


Val Trp Ser Ile Ser Ile Thr Asn Thr Ser Val His Thr Gly Leu Met 
145                 150                 155                 160 


Leu Arg Leu Pro Phe Cys Gly Ser Asn Glu Ile Glu His Phe Phe Cys 
                165                 170                 175     


Glu Ile Pro Pro Leu Leu Lys Leu Ser Cys Ala Pro Thr Gln Leu Asn 
            180                 185                 190         


Glu Ala Met Ala Phe Ala Ala Asp Val Phe Leu Ala Val Gly Asn Phe 
        195                 200                 205             


Ser Val Thr Ile Leu Ser Tyr Gly Phe Ile Val Val Ser Ile Leu Arg 
    210                 215                 220                 


Ile Arg Ser Ala Glu Gly Lys Arg Arg Ala Phe Ser Thr Cys Ser Ala 
225                 230                 235                 240 


His Leu Ile Val Val Thr Met Tyr Tyr Ser Thr Val Ile Tyr Thr Tyr 
                245                 250                 255     


Ile Arg Pro Ala Ser Ser Tyr Ser Leu Asn Lys Asp Lys Val Val Ser 
            260                 265                 270         


Ile Ile Tyr Thr Ser Val Ala Pro Thr Leu Asn Pro Leu Ile Tyr Thr 
        275                 280                 285             


Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Arg Leu Leu Ser Cys 
    290                 295                 300                 


Ser 
305 


<210>  10
<211>  317
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Asp Ser Pro Ser Asn Ser Thr Ile Ser Arg Gly Phe Leu Leu Gln 
1               5                   10                  15      


Gly Phe Phe Glu Phe Pro His Leu Arg Pro Leu Leu Phe Leu Val Leu 
            20                  25                  30          


Leu Ala Val His Leu Ala Thr Leu Ser Gly Asn Leu Leu Ile Leu Val 
        35                  40                  45              


Ala Val Val Ser Val Pro Ser Arg Pro Pro Met Leu Leu Phe Leu Cys 
    50                  55                  60                  


Gln Leu Ser Ala Ile Glu Leu Cys Tyr Thr Leu Val Val Val Pro Arg 
65                  70                  75                  80  


Ser Leu Ala Asp Leu Ser Met Pro Gly His Gly Arg Gly Ser Pro Ile 
                85                  90                  95      


Ser Phe Leu Gly Cys Ala Val Gln Met Gln Met Phe Val Ala Leu Gly 
            100                 105                 110         


Gly Ala Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 
        115                 120                 125             


Ala Ile Cys His Pro Leu Arg Tyr Ala Ser Ile Val Thr Pro Gly Leu 
    130                 135                 140                 


Cys Ala Arg Leu Ala Leu Ala Cys Cys Leu Gly Gly Leu Ala Val Ser 
145                 150                 155                 160 


Val Gly Leu Thr Val Ala Val Phe His Leu Pro Phe Cys Gly Ser Arg 
                165                 170                 175     


Leu Leu Val His Phe Phe Cys Asp Ile Thr Ala Leu Leu His Leu Ala 
            180                 185                 190         


Cys Thr Arg Ser Tyr Ile Asp Glu Leu Pro Leu Leu Gly Ala Cys Leu 
        195                 200                 205             


Val Leu Leu Leu Leu Pro Ser Met Leu Ile Leu Thr Ser Tyr Gly Ala 
    210                 215                 220                 


Ile Ala Ser Ala Leu Arg Arg Leu His Gly Gly Gly Gly Arg Arg Lys 
225                 230                 235                 240 


Ala Ala Ser Thr Cys Ala Ser His Leu Ala Val Thr Phe Leu His Tyr 
                245                 250                 255     


Gly Cys Ala Thr Phe Met Tyr Val Arg Pro Lys Ser Ser Tyr Ser Pro 
            260                 265                 270         


Arg Leu Asp Arg Thr Leu Ala Leu Val Tyr Thr Asn Val Thr Pro Leu 
        275                 280                 285             


Leu Tyr Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Ile Thr Ser Ala 
    290                 295                 300                 


Ile His Arg Val Leu Gly Leu Arg Gly Ser Gly Ser Met 
305                 310                 315         


<210>  11
<211>  308
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Gly Tyr Gly Asn Ile Thr Glu Phe Ile Leu Leu Gly Leu Phe His 
1               5                   10                  15      


Asp Glu Asp Val Lys Ala Ile Cys Ala Val Leu Phe Leu Leu Cys Tyr 
            20                  25                  30          


Leu Ala Ile Leu Cys Gly Asn Leu Ile Val Leu Leu Thr Ile Lys Gly 
        35                  40                  45              


Ser Gln Leu Ser Glu Gln Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser 
    50                  55                  60                  


Phe Met Asp Val Cys Phe Thr Ser Thr Val Ala Pro Lys Phe Ile Ile 
65                  70                  75                  80  


Gly Leu Leu Val Gln Cys Asn Thr Ile Ser Tyr Asn Ala Cys Ile Ala 
                85                  90                  95      


Gln Met Phe Tyr Ala His Phe Phe Gly Ala Thr Glu Ile Phe Ile Leu 
            100                 105                 110         


Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu Tyr 
        115                 120                 125             


Tyr Met Ile Thr Met Ser Arg Gln Val Cys Tyr Ile Leu Val Ile Gly 
    130                 135                 140                 


Ser Val Phe Gly Ala Phe Ile His Ser Leu Val His Val Leu Val Ile 
145                 150                 155                 160 


Ile Arg Leu Pro Phe Cys Gly Thr Asn Glu Ile Asp His Tyr Phe Cys 
                165                 170                 175     


Asp Ile Phe Pro Leu Leu Lys Leu Ala Cys Thr Glu Thr Arg Leu Leu 
            180                 185                 190         


Val Ile Val Ile Ile Thr Thr Thr Gly Val Met Ser Ile Leu Thr Phe 
        195                 200                 205             


Val Ala Leu Val Ile Ser Tyr Ile Ile Ile Leu Ser Ile Leu Arg Thr 
    210                 215                 220                 


Arg Ser Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser His 
225                 230                 235                 240 


Ile Thr Val Val Phe Met Phe Phe Leu Pro Leu Ile Phe Thr Tyr Val 
                245                 250                 255     


Pro Met Gly Asp Ser Val Gly Asp Asp Lys Val Phe Ala Leu Phe Tyr 
            260                 265                 270         


Thr Met Ile Ala Pro Leu Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn 
        275                 280                 285             


Thr Asp Met Lys Asn Ala Met Arg Lys Val Trp Cys Gln Asp Lys Leu 
    290                 295                 300                 


Phe Glu Gly Lys 
305             


<210>  12
<211>  312
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Asn Glu Ile Asn Tyr Thr Lys Val Ser Glu Phe Val Phe Leu Gly 
1               5                   10                  15      


Leu Ser Lys Ser Lys Glu Ile Gln His Phe Phe Leu Ala Phe Ser Val 
            20                  25                  30          


Val Leu Tyr Val Ala Ile Val Leu Gly Asn Thr Leu Val Val Phe Thr 
        35                  40                  45              


Leu Ala Leu Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Ile Asp Leu Cys Phe Ser Thr Leu Thr Val Pro Lys 
65                  70                  75                  80  


Met Ile Ser Asp Leu Ser Ser Gly His Asn Thr Ile Ser Phe His Gly 
                85                  90                  95      


Cys Val Phe Gln Ile Phe Val Ile His Val Leu Gly Ala Ser Glu Met 
            100                 105                 110         


Val Leu Leu Val Val Met Ala Trp Asp Arg Tyr Val Ala Ile Cys Lys 
        115                 120                 125             


Pro Leu His Tyr Leu Thr Ile Met Asn Pro Arg Ile Cys Ile Leu Leu 
    130                 135                 140                 


Leu Ser Gly Ala Trp Ile Ile Ala Phe Leu His Ser Val Ile Gln Leu 
145                 150                 155                 160 


Gly Phe Val Val His Leu Arg Phe Cys Gly Pro Asn Glu Ile Asp Ser 
                165                 170                 175     


Phe Tyr Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Met Asp Asn 
            180                 185                 190         


Tyr Arg Met Glu Phe Met Val Ala Ala Asn Ser Gly Ile Ile Ser Ile 
        195                 200                 205             


Gly Thr Phe Phe Leu Leu Ile Ile Ser Tyr Ile Val Ile Leu Leu Thr 
    210                 215                 220                 


Val Arg Lys His Ser Ser Gly Asp Leu Ser Lys Ala Leu Ser Thr Leu 
225                 230                 235                 240 


Ser Ala His Ile Ser Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe 
                245                 250                 255     


Val Tyr Met Trp Pro Phe Pro Thr Val Pro Val Asp Lys Phe Leu Ala 
            260                 265                 270         


Ile Leu Asp Phe Met Ile Thr Pro Ile Leu Asn Pro Ala Ile Tyr Thr 
        275                 280                 285             


Leu Arg Asn Lys Asp Met Lys Val Ala Met Arg Lys Leu Ser Val Gln 
    290                 295                 300                 


Leu Leu His Phe Arg Lys Met Ser 
305                 310         


<210>  13
<211>  308
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Ser Leu Ser Asp Asn Pro Glu Leu Gln Pro Ile Leu Phe Val Leu 
1               5                   10                  15      


Phe Leu Ser Phe Tyr Met Val Thr Val Leu Gly Asn Leu Leu Ile Ile 
            20                  25                  30          


Leu Ala Val Ser Ser Asp Phe His Leu His Thr Pro Met Tyr Phe Phe 
        35                  40                  45              


Leu Ser Asn Leu Ser Trp Ser Asp Ile Cys Leu Ile Ser Thr Thr Val 
    50                  55                  60                  


Pro Lys Met Ile Trp Asp Ile Arg Thr Gln Ser Arg Val Ile Ser Tyr 
65                  70                  75                  80  


Ala Gly Cys Leu Thr Gln Met Ser Met Phe Ile Ile Phe Gly Cys Met 
                85                  90                  95      


Asp Ser Met Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile 
            100                 105                 110         


Cys His Pro Leu Asn Tyr Asn Ile Ile Met Asn Pro Asn Leu Cys Ala 
        115                 120                 125             


Leu Leu Leu Leu Ala Ser Val Leu Ala Ser Leu Val Asp Ser Gln Val 
    130                 135                 140                 


His Asn Leu Ile Val Leu Gln Phe Thr Tyr Phe Asn Asp Met Glu Ile 
145                 150                 155                 160 


Ser Asn Phe Phe Cys Glu Pro Ser Gln Leu Leu Asn Leu Lys Cys Ser 
                165                 170                 175     


Glu Met Phe Thr Lys Asn Ile Val Ile Arg Phe Ile Gly Val Phe Phe 
            180                 185                 190         


Gly Leu Phe Ser Thr Ser Gly Ile Ile Phe Ser Tyr Tyr Lys Ile Val 
        195                 200                 205             


Ser Ser Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys Tyr Lys Ala Phe 
    210                 215                 220                 


Ser Thr Cys Val Ser His Leu Ser Val Val Cys Leu Phe Tyr Gly Thr 
225                 230                 235                 240 


Ala Ile Gly Val Tyr Ile Gly Ser Thr Ala Ser Asn Ser Ser Glu Asn 
                245                 250                 255     


Cys Lys Val Ala Ser Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn 
            260                 265                 270         


Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Thr Ala Leu Trp 
        275                 280                 285             


Lys Leu Gln Lys Lys Ala Lys Leu His Asn Ala Phe His His Phe Leu 
    290                 295                 300                 


Ile Leu Ser Ser 
305             


<210>  14
<211>  313
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Ser Ser Thr Asn His Ser Ser Val Ser Val Phe Leu Leu Leu Gly 
1               5                   10                  15      


Leu Ser Arg Gln Pro Gln Gln Gln Gln Leu Leu Phe Leu Leu Phe Leu 
            20                  25                  30          


Ile Met Tyr Leu Ala Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ser 
        35                  40                  45              


Ile Ser Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Val Leu Thr Asn His Ile Leu Gly Ser Gln Glu Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Phe Leu Ser Val Phe Ala Asp Met Asp Asn 
            100                 105                 110         


Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Thr Lys Lys Met Thr His Gln Leu Cys Ala Leu Leu 
    130                 135                 140                 


Val Val Glu Ser Trp Leu Ala Val Asn Leu Asn Ala Leu Leu His Thr 
145                 150                 155                 160 


Leu Leu Met Ala Arg Leu Ser Phe Cys Gly Asp Asn Leu Ile Pro His 
                165                 170                 175     


Tyr Phe Cys Asp Ala Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 
            180                 185                 190         


His Leu Asn Glu Leu Met Ile Asn Thr Glu Gly Ala Val Thr Met Val 
        195                 200                 205             


Thr Pro Phe Val Cys Ile Leu Ile Ser Tyr Ile His Ile Thr Cys Ala 
    210                 215                 220                 


Val Leu Arg Val Ser Ser Pro Arg Gly Gly Trp Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Ile Ile 
                245                 250                 255     


Ala Val Tyr Phe Asn Pro Ser Thr Ala His Ser Pro Glu Lys Asp Thr 
            260                 265                 270         


Val Ala Thr Val Leu Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Trp Ser Leu Arg Lys Leu 
    290                 295                 300                 


Val His Arg Ser Thr Phe Ser Phe Gln 
305                 310             


<210>  15
<211>  315
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Met Lys Ala Asn His Ser Leu Glu Phe Ile Leu Ile Gly Phe Thr 
1               5                   10                  15      


Asp His Pro Asp Leu Lys Thr Leu Leu Phe Leu Val Phe Ser Ala Ile 
            20                  25                  30          


Tyr Leu Val Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu Ile Tyr 
        35                  40                  45              


Met Glu Pro Arg Phe His Thr Pro Met Tyr Ile Phe Leu Gly Asn Leu 
    50                  55                  60                  


Ala Leu Met Asp Ser Cys Cys Ser Cys Ala Ile Thr Pro Lys Met Leu 
65                  70                  75                  80  


Glu Asn Phe Phe Ser Val Asp Arg Arg Ile Ser Phe Cys Glu Cys Met 
                85                  90                  95      


Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys Phe Leu 
            100                 105                 110         


Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 
        115                 120                 125             


Gln Tyr His Thr Met Met Ser Lys Lys Leu Ser Leu Gln Met Ser Met 
    130                 135                 140                 


Gly Ile Phe Ile Ala Ser Asn Leu His Ser Leu Ile His Thr Gly Cys 
145                 150                 155                 160 


Leu Leu Arg Leu Asn Phe Cys Lys Ser Thr Lys Ile Asp His Phe Phe 
                165                 170                 175     


Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Thr Asn Pro Phe Ile 
            180                 185                 190         


Asn Glu Leu Met Ile Tyr Ile Phe Ser Met Pro Ile Gln Val Phe Thr 
        195                 200                 205             


Ile Thr Thr Ile Leu Val Ser Tyr Phe Cys Ile Leu Phe Thr Ile Phe 
    210                 215                 220                 


Lys Met Lys Ser Lys Asp Gly Arg Gly Lys Ala Phe Ser Thr Cys Ala 
225                 230                 235                 240 


Ser His Phe Phe Ser Val Ser Ile Phe Tyr Thr Cys Leu Leu Met Tyr 
                245                 250                 255     


Ile Gly Pro Ser Glu Asp Gly Ser Lys Asp Ile Pro Val Ala Val Phe 
            260                 265                 270         


Tyr Thr Val Ile Ile Pro Leu Leu Asn Pro Phe Ile Tyr Ser Leu Arg 
        275                 280                 285             


Asn Lys Glu Val Val Asn Ala Val Lys Lys Val Met Lys Thr Tyr Ser 
    290                 295                 300                 


Ile Phe Lys Asn Ala Ser Ala Ser Ile Val His 
305                 310                 315 


<210>  16
<211>  316
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Val Pro Met Glu Arg Asn Val Ser Val Glu Ile Ile Phe Val Leu 
1               5                   10                  15      


Val Gly Phe Thr Asp Tyr Pro Glu Leu Gln Ile Pro Leu Phe Leu Val 
            20                  25                  30          


Phe Leu Phe Met Tyr Ile Ile Thr Val Val Gly Asn Leu Gly Met Ile 
        35                  40                  45              


Val Leu Ile Asn Ile Asp Pro Lys Phe His Thr Pro Met Tyr Phe Phe 
    50                  55                  60                  


Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Pro Thr Ile Ile Met 
65                  70                  75                  80  


Pro Lys Leu Leu Glu Asn Leu Ile Leu Ala Asp Lys Thr Ile Leu Tyr 
                85                  90                  95      


Phe Ser Cys Met Leu Gln Tyr Phe Leu Ser Cys Val Ala Val Val Ala 
            100                 105                 110         


Glu Ser Tyr Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile 
        115                 120                 125             


Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Arg Leu Cys Ile 
    130                 135                 140                 


Leu Leu Val Thr Gly Ser Tyr Ile Trp Ser Thr Leu Ala Thr Leu Ile 
145                 150                 155                 160 


Leu Leu Cys Tyr Ala Leu Gln Leu Lys Phe Ser Arg Phe Thr Val Ile 
                165                 170                 175     


Asn His Phe Phe Cys Glu Tyr Thr Ala Leu Ile Ala Val Ser Ser Ser 
            180                 185                 190         


Asp Ile His Ile Pro Ser Leu Leu Leu Phe Cys Phe Ala Thr Phe Asn 
        195                 200                 205             


Glu Val Ser Thr Leu Leu Ile Ile Leu Thr Ser Tyr Val Phe Ile Phe 
    210                 215                 220                 


Val Thr Val Leu Lys Ile Lys Ser Ala Ser Gly Arg Arg Lys Ala Phe 
225                 230                 235                 240 


Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr 
                245                 250                 255     


Ile Leu Ser Leu Tyr Cys Val Pro Asn Pro Gln Asn Ser Arg Asn Ala 
            260                 265                 270         


Val Lys Val Ala Ser Val Phe Tyr Ala Val Val Asn Pro Leu Leu Asn 
        275                 280                 285             


Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Val Leu Gln 
    290                 295                 300                 


Lys Val Val Ser Thr Ser Leu Lys Phe Pro Leu His 
305                 310                 315     


<210>  17
<211>  317
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Gly Gln Ser Asn Asn Val Thr Glu Phe Val Leu Leu Gly Phe Thr 
1               5                   10                  15      


Gln Asp Pro Ala Gly Gln Lys Ala Leu Phe Val Met Phe Ser Leu Met 
            20                  25                  30          


Tyr Ile Ala Thr Met Val Gly Asn Leu Leu Ile Val Gly Thr Val Ile 
        35                  40                  45              


Val Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu 
    50                  55                  60                  


Ser Leu Met Asp Ala Val Tyr Ser Thr Ala Ile Ser Pro Lys Leu Ile 
65                  70                  75                  80  


Val Asp Leu Leu Arg Glu Lys Lys Thr Ile Ser Phe Arg Ala Cys Ile 
                85                  90                  95      


Ser Gln Leu Phe Ile Glu His Leu Phe Gly Gly Val Asp Ile Val Ile 
            100                 105                 110         


Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 
        115                 120                 125             


His Tyr Leu Thr Ile Met Asn Arg Arg Val Cys Ile Leu Phe Leu Val 
    130                 135                 140                 


Met Ala Trp Ala Gly Gly Phe Ala His Ala Leu Phe Gln Val Leu Ala 
145                 150                 155                 160 


Val Tyr Asn Leu Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Gly 
                165                 170                 175     


Cys Asp Ile Tyr Pro Leu Leu Leu Leu Ala Cys Thr Asp Thr Tyr Phe 
            180                 185                 190         


Ile Gly Leu Ser Val Ile Gly Asn Asn Gly Ala Met Cys Ile Val Ile 
        195                 200                 205             


Phe Ser Leu Leu Leu Phe Ser Tyr Gly Ile Ile Leu Arg Ser Leu Gln 
    210                 215                 220                 


Asn His Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser 
225                 230                 235                 240 


His Ile Thr Val Val Phe Leu Phe Phe Val Pro Cys Ile Phe Met Tyr 
                245                 250                 255     


Val Arg Pro Val Ser Ser Phe Pro Ile Asp Lys Ser Ile Thr Val Ile 
            260                 265                 270         


Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 
        275                 280                 285             


Asn Ser Glu Met Lys Asn Ser Met Glu Lys Leu Leu Gln Lys Ile Leu 
    290                 295                 300                 


Ser Pro Asn Arg Leu Arg Leu Leu Cys Cys Leu His Tyr 
305                 310                 315         


<210>  18
<211>  309
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Glu Thr Tyr Asn Leu Thr Gly Thr Leu Glu Phe Leu Leu Leu Asp 
1               5                   10                  15      


Leu Ser Glu Asp Thr Glu Leu Gln Phe Ile Phe Phe Val Leu Phe Leu 
            20                  25                  30          


Leu Ile Tyr Leu Leu Thr Val Leu Gly Asn Val Leu Ile Ile Leu Ala 
        35                  40                  45              


Ile Ser Ser Asp Ser Gln Leu His Ser Pro Met Tyr Phe Phe Leu Tyr 
    50                  55                  60                  


Asn Leu Ser Leu Ser Asp Met Gly Phe Ser Ser Thr Thr Val Pro Lys 
65                  70                  75                  80  


Met Leu Ile Asn Met Gln Thr His Asn Lys Ser Ile Thr Tyr Ala Gly 
                85                  90                  95      


Cys Leu Thr Gln Val Phe Phe Phe Ile Leu Phe Gly Gly Met Asp Ser 
            100                 105                 110         


Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Trp Val Ala Ile Cys His 
        115                 120                 125             


Pro Leu His Tyr Gln Val Ile Leu Asn Pro Arg Leu Cys Arg Cys Leu 
    130                 135                 140                 


Leu Ile Leu Ser Phe Phe Ile Ser Val Leu Ser Ser Gln Val His Cys 
145                 150                 155                 160 


Leu Met Val Ser Gln Leu Thr Phe Cys Thr Asn Met Glu Ile His His 
                165                 170                 175     


Phe Phe Cys Asp Val Pro Glu Leu Leu Lys Leu Ser Cys Ser Asp Ser 
            180                 185                 190         


Phe Ile Ser Asn Ile Val Arg Ile Ile Leu Ser Ile Ile Leu Gly Phe 
        195                 200                 205             


Leu Pro Met Ser Gly Ile Leu Tyr Ser Tyr Tyr Lys Ile Thr Ser Ser 
    210                 215                 220                 


Ile Phe Lys Phe Pro Ser Leu Leu Gly Lys Tyr Lys Val Phe Ser Thr 
225                 230                 235                 240 


Cys Gly Ser His Leu Ser Val Val Cys Leu Phe Tyr Gly Thr Gly Ile 
                245                 250                 255     


Gly Val Tyr Leu Ser Ser Thr Val Ser Ser Ser Tyr Gly Glu Ser Met 
            260                 265                 270         


Val Ala Ser Val Leu Tyr Ile Met Val Val Pro Met Ile Asn Pro Phe 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Lys Ala Leu Gln Lys Ile 
    290                 295                 300                 


Val Arg Gln Ile Leu 
305                 


<210>  19
<211>  319
<212>  PRT
<213>  Mus musculus

<400>  19

Met Asp Arg Ser Asn Glu Thr Ala Pro Leu Ser Gly Phe Ile Leu Leu 
1               5                   10                  15      


Gly Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile 
            20                  25                  30          


Leu Met Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 
        35                  40                  45              


Val Ser Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 
65                  70                  75                  80  


Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser 
                85                  90                  95      


Gly Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 
            100                 105                 110         


Cys Val Leu Leu Ser Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Asn Pro Leu Arg Tyr Pro Val Val Met Asn Lys Ala Ala Tyr Val Pro 
    130                 135                 140                 


Met Ala Ala Ser Ser Trp Ala Gly Gly Ile Thr Asn Ser Val Val Gln 
145                 150                 155                 160 


Thr Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 
                165                 170                 175     


His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 
            180                 185                 190         


Ile Ser Ile Asn Val Ile Ser Met Val Val Ala Asn Met Ile Phe Leu 
        195                 200                 205             


Ala Val Pro Val Leu Phe Ile Phe Val Ser Tyr Val Phe Ile Leu Val 
    210                 215                 220                 


Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ala His Leu Thr Val Val Leu Val Phe Tyr Gly Thr Ile 
                245                 250                 255     


Leu Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp 
            260                 265                 270         


Lys Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val 
        275                 280                 285             


Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 
    290                 295                 300                 


Arg Ala Ala Val Arg Asn Leu Val Gly Gln Lys His Leu Thr Glu 
305                 310                 315                 


<210>  20
<211>  318
<212>  PRT
<213>  Mus musculus

<400>  20

Met Glu Gly Ala Asn Gln Ser Thr Val Ala Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Asp His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 
        35                  40                  45              


Ser Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Leu 
65                  70                  75                  80  


Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Val Met Asn Lys Ser Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Leu Val Gln Ile 
145                 150                 155                 160 


Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 
        195                 200                 205             


Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Leu Val Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 
            260                 265                 270         


Gln Asp Val Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Leu Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Ala Ala Val Arg Asn Leu Val Gly Gln Lys Cys Leu Ile Gln 
305                 310                 315             


<210>  21
<211>  318
<212>  PRT
<213>  Mus musculus

<400>  21

Met Asp Val Ser Asn Gln Thr Thr Val Thr Glu Phe Val Leu Leu Gly 
1               5                   10                  15      


Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Ser Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 
        35                  40                  45              


Ser Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro Leu 
65                  70                  75                  80  


Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Val Met Asn Lys Ala Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Leu Val Gln Ile 
145                 150                 155                 160 


Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 
                165                 170                 175     


Phe Ile Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 
        195                 200                 205             


Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 
            260                 265                 270         


Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Leu Leu Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Ala Ala Val Arg Asn Leu Ala Ser His Arg Cys Leu Thr Phe 
305                 310                 315             


<210>  22
<211>  319
<212>  PRT
<213>  Mus musculus

<400>  22

Met Glu Arg Ser Asn Lys Thr Thr Pro Val Ser Ser Phe Ile Leu Leu 
1               5                   10                  15      


Gly Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile 
            20                  25                  30          


Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Val Val Leu Ile Leu 
        35                  40                  45              


Val Ser Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 
65                  70                  75                  80  


Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser 
                85                  90                  95      


Gly Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 
            100                 105                 110         


Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 
    130                 135                 140                 


Met Ala Ala Gly Ser Trp Val Ser Gly Ser Ile Thr Ala Thr Val Gln 
145                 150                 155                 160 


Ile Ser Leu Ala Met Thr Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 
                165                 170                 175     


His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 
            180                 185                 190         


Ile Ser Ile Asn Val Ile Ser Met Ala Val Ala Asn Ala Met Phe Leu 
        195                 200                 205             


Gly Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser 
    210                 215                 220                 


Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ala His Leu Thr Val Val Leu Val Phe Tyr Gly Thr Ile 
                245                 250                 255     


Leu Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp 
            260                 265                 270         


Lys Gln Asp Leu Ala Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val 
        275                 280                 285             


Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 
    290                 295                 300                 


Lys Ala Ala Val Thr Asn Leu Val Gly Gln Lys His Phe Lys Trp 
305                 310                 315                 


<210>  23
<211>  319
<212>  PRT
<213>  Mus musculus

<400>  23

Met Val Gln Gly Asn Trp Thr Ser Val Thr Val Phe Val Phe Leu Gly 
1               5                   10                  15      


Phe Ser His Tyr Pro Arg Ile Glu Val Thr Val Phe Val Leu Cys Leu 
            20                  25                  30          


Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Thr Ile Leu Ile Ser Ile 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Ala Leu Thr Pro 
65                  70                  75                  80  


Met Leu Ala Asn Phe Val Ser Gly Lys Asn Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Ser Gln Met Tyr Phe Ser Leu Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Arg Val Cys Val Gln Ile 
    130                 135                 140                 


Ala Gly Ser Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Val Glu Thr 
145                 150                 155                 160 


Gly Pro Val Ile His Leu Ser Leu Cys Gly Asn Ser Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Leu Leu Lys Leu Ala Cys Gly Asp Thr 
            180                 185                 190         


Ser Met Val Gln Leu Ile Met Leu Val Ile Ser Ile Leu Leu Leu Pro 
        195                 200                 205             


Leu Pro Met Leu Leu Ile Cys Val Ser Tyr Ala Ser Ile Leu Ser Asn 
    210                 215                 220                 


Ile Leu Arg Ile Ser Ser Met Asp Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ala His Leu Thr Val Val Val Leu Phe Tyr Gly Thr Ala Leu 
                245                 250                 255     


Ser Met Tyr Leu Lys Pro Ser Ser Val Asn Ser Gln Glu Ile Asp Lys 
            260                 265                 270         


Phe Met Ala Leu Ile Tyr Thr Gly Leu Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Met Ala Val Lys Lys Leu 
    290                 295                 300                 


Leu Met Lys Asn Pro Phe Ser Ala Ile Leu Thr Ser Val Leu Lys 
305                 310                 315                 


<210>  24
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Lys Ile Asn Gln Thr Ile Leu Lys Glu Phe Ile Leu Val Gly Phe 
1               5                   10                  15      


Ser Val Tyr Pro His Val Gln Thr Phe Leu Phe Val Val Phe Phe Cys 
            20                  25                  30          


Leu Tyr Leu Leu Thr Leu Ala Gly Asn Leu Ile Ile Met Gly Leu Thr 
        35                  40                  45              


Trp Val Asp Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Ser Ala 
    50                  55                  60                  


Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Thr Ile Val Pro Lys Met 
65                  70                  75                  80  


Leu Glu Asp Leu Leu Ala Lys Asp Arg Ser Ile Ser Val Thr Gly Cys 
                85                  90                  95      


Ser Leu Gln Met Cys Phe Phe Leu Gly Leu Gly Gly Thr Asn Cys Ile 
            100                 105                 110         


Ile Leu Thr Leu Met Gly Tyr Asp Arg Phe Leu Ala Ile Cys Asn Pro 
        115                 120                 125             


Leu Arg Tyr Pro Leu Leu Met Thr Asn Ile Val Cys Gly Gln Leu Val 
    130                 135                 140                 


Ala Ser Ala Cys Thr Ala Gly Phe Phe Ile Ser Leu Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Ile Phe Arg Asp Ser Phe Cys Arg Pro Asn Leu Val Lys His Phe 
                165                 170                 175     


Phe Cys His Met Leu Ala Val Ile Arg Leu Ser Cys Ile Asp Ser Asn 
            180                 185                 190         


His Thr Glu Phe Ile Ile Thr Leu Ile Ser Val Ser Gly Leu Leu Gly 
        195                 200                 205             


Thr Leu Leu Leu Ile Ile Leu Thr Asp Val Phe Ile Ile Ser Thr Val 
    210                 215                 220                 


Leu Arg Ile Pro Ser Ala Glu Gly Lys Gln Lys Ala Phe Thr Thr Cys 
225                 230                 235                 240 


Ala Ser His Leu Thr Val Val Ile Ile His Phe Gly Phe Ala Ser Ile 
                245                 250                 255     


Val Tyr Leu Lys Pro Glu Ala Ser Gly Asp Asp Thr Leu Ile Ala Val 
            260                 265                 270         


Pro Tyr Thr Val Ile Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu 
        275                 280                 285             


Arg Asn Lys Asp Met Lys Asn Ala Phe Arg Arg Met Met Gly Asn Thr 
    290                 295                 300                 


Val Ala Leu Lys Lys 
305                 


<210>  25
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser 
            20                  25                  30          


Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val 
        35                  40                  45              


Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu 
65                  70                  75                  80  


Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val 
                85                  90                  95      


Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys 
            100                 105                 110         


Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln 
        115                 120                 125             


Pro Leu Arg Tyr Arg Val Leu Met Ser His Arg Leu Cys Val Leu Leu 
    130                 135                 140                 


Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met 
145                 150                 155                 160 


Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His 
                165                 170                 175     


Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr 
            180                 185                 190         


Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro 
        195                 200                 205             


Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr 
    210                 215                 220                 


Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile 
                245                 250                 255     


Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu 
            260                 265                 270         


Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val 
    290                 295                 300                 


Trp Gly Arg Ser Arg Ala Ser Arg 
305                 310         


<210>  26
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Lys Ala Asn Glu Thr Ser Pro Val Met Gly Phe Val Leu Leu 
1               5                   10                  15      


Arg Leu Ser Ala His Pro Glu Leu Glu Lys Thr Phe Phe Val Leu Ile 
            20                  25                  30          


Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 
        35                  40                  45              


Val Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 
    50                  55                  60                  


Gly Asn Leu Ser Phe Leu Asp Ile Cys Phe Thr Thr Ser Ser Val Pro 
65                  70                  75                  80  


Leu Val Leu Asp Ser Phe Leu Thr Pro Gln Glu Thr Ile Ser Phe Ser 
                85                  90                  95      


Ala Cys Ala Val Gln Met Ala Leu Ser Phe Ala Met Ala Gly Thr Glu 
            100                 105                 110         


Cys Leu Leu Leu Ser Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 
        115                 120                 125             


Asn Pro Leu Arg Tyr Ser Val Ile Met Ser Lys Ala Ala Tyr Met Pro 
    130                 135                 140                 


Met Ala Ala Ser Ser Trp Ala Ile Gly Gly Ala Ala Ser Val Val His 
145                 150                 155                 160 


Thr Ser Leu Ala Ile Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 
                165                 170                 175     


His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 
            180                 185                 190         


Ile Ser Ile Asn Val Ile Ser Met Glu Val Thr Asn Val Ile Phe Leu 
        195                 200                 205             


Gly Val Pro Val Leu Phe Ile Ser Phe Ser Tyr Val Phe Ile Ile Thr 
    210                 215                 220                 


Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Val Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Leu 
                245                 250                 255     


Phe Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Ser Met Gly Ala Asp 
            260                 265                 270         


Lys Glu Asp Leu Ser Asp Lys Leu Ile Pro Leu Phe Tyr Gly Val Val 
        275                 280                 285             


Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 
    290                 295                 300                 


Lys Ala Ala Val Arg Arg Leu Leu Arg Pro Lys Gly Phe Thr Gln 
305                 310                 315                 


<210>  27
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Leu Ser Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu 
            20                  25                  30          


Val Met Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala 
        35                  40                  45              


Ser Ile Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Leu Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met 
    130                 135                 140                 


Ala Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr 
145                 150                 155                 160 


Leu Leu Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Ala Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Leu Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val 
        195                 200                 205             


Leu Pro Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 
    210                 215                 220                 


Ile Leu Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 
                245                 250                 255     


Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys 
            260                 265                 270         


Leu Gln Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Ala Ala Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His 
305                 310                 315         


<210>  28
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly 
1               5                   10                  15      


Leu Ser Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu 
            20                  25                  30          


Val Met Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala 
        35                  40                  45              


Ser Ile Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Leu Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met 
    130                 135                 140                 


Ala Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr 
145                 150                 155                 160 


Leu Leu Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Ala Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Leu Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val 
        195                 200                 205             


Leu Pro Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 
    210                 215                 220                 


Ile Leu Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 
                245                 250                 255     


Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys 
            260                 265                 270         


Leu Gln Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Ala Ala Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His 
305                 310                 315         


<210>  29
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Arg Thr Asn Asp Ser Thr Ser Thr Glu Phe Phe Leu Val Gly 
1               5                   10                  15      


Leu Ser Asp His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Ile Leu 
            20                  25                  30          


Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val 
        35                  40                  45              


Ile Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Ser Ser Val Pro Leu 
65                  70                  75                  80  


Ile Leu Ala Ser Phe Leu Ala Val Lys Lys Lys Val Ser Phe Ser Gly 
                85                  90                  95      


Cys Met Val Gln Met Phe Ile Ser Phe Ala Met Gly Ala Thr Glu Cys 
            100                 105                 110         


Met Ile Leu Gly Thr Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr 
        115                 120                 125             


Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Gly Ala Tyr Val Ala Met 
    130                 135                 140                 


Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr 
145                 150                 155                 160 


Ala Phe Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Lys His 
                165                 170                 175     


Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Ile Asn Val Ile Ser Met Thr Gly Ser Asn Leu Ile Val Leu Val 
        195                 200                 205             


Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Ala Thr 
    210                 215                 220                 


Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys His Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 
                245                 250                 255     


Phe Met Tyr Ala Lys Pro Glu Ser Lys Ala Ser Val Asp Ser Gly Asn 
            260                 265                 270         


Glu Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr 
        275                 280                 285             


Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Ala Ala Val Lys Asn Ile Leu Cys Arg Lys Asn Phe Ser Asp Gly Lys 
305                 310                 315                 320 


<210>  30
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Trp Glu Asn His Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


Leu Ser Gly His Pro Arg Leu Glu Leu Leu Phe Phe Val Leu Ile Phe 
            20                  25                  30          


Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 
        35                  40                  45              


Ser Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Ser Leu Ala Met Gly Thr Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Thr 
145                 150                 155                 160 


Val Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Gly Asn Glu Phe Ile Leu Leu Val Thr Thr Thr Leu Phe Leu Leu 
        195                 200                 205             


Thr Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Leu Ser 
    210                 215                 220                 


Ile Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Pro Ser Ser Thr 
225                 230                 235                 240 


Cys Ser Ala Arg Leu Thr Val Val Ile Thr Phe Cys Gly Thr Ile Phe 
                245                 250                 255     


Leu Met Tyr Met Lys Pro Lys Ser Gln Glu Thr Leu Asn Ser Asp Asp 
            260                 265                 270         


Leu Asp Ala Thr Asp Lys Leu Ile Phe Ile Phe Tyr Arg Val Met Thr 
        275                 280                 285             


Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Glu Ala Val Lys His Leu Leu Arg Arg Lys Asn Phe Asn Lys 
305                 310                 315             


<210>  31
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Trp Glu Asn His Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


Leu Ser Gly His Pro Arg Leu Glu Leu Leu Phe Phe Val Leu Ile Phe 
            20                  25                  30          


Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 
        35                  40                  45              


Ser Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Ser 
145                 150                 155                 160 


Val Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Asp Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu 
        195                 200                 205             


Thr Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Val Ser 
    210                 215                 220                 


Ile Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Ala Ser Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp 
            260                 265                 270         


Leu Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr 
        275                 280                 285             


Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Glu Ala Val Lys His Leu Leu Asn Arg Arg Phe Phe Ser Lys 
305                 310                 315             


<210>  32
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Trp Glu Asn Gln Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 
1               5                   10                  15      


His Ser Val His Pro Arg Leu Glu Leu Leu Phe Phe Val Leu Ile Phe 
            20                  25                  30          


Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 
        35                  40                  45              


Ser Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 
65                  70                  75                  80  


Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Asn Ala Tyr Val Pro Met 
    130                 135                 140                 


Ala Val Gly Ser Trp Phe Ala Gly Ile Val Asn Ser Ala Val Gln Thr 
145                 150                 155                 160 


Thr Phe Val Val Gln Leu Pro Phe Cys Arg Lys Asn Val Ile Asn His 
                165                 170                 175     


Phe Ser Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 
            180                 185                 190         


Ser Gly Asn Glu Phe Leu Met Leu Val Ala Thr Ile Leu Phe Thr Leu 
        195                 200                 205             


Met Pro Leu Leu Leu Ile Val Ile Ser Tyr Ser Leu Ile Ile Ser Ser 
    210                 215                 220                 


Ile Leu Lys Ile His Ser Ser Glu Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 
                245                 250                 255     


Phe Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp 
            260                 265                 270         


Leu Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr 
        275                 280                 285             


Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 
    290                 295                 300                 


Glu Ala Val Lys His Leu Pro Asn Arg Arg Phe Phe Ser Lys 
305                 310                 315             


<210>  33
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Thr Arg Asn Tyr Ser Ala Met Thr Glu Phe Phe Leu Val Gly 
1               5                   10                  15      


Leu Ser Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Leu Leu Cys Leu 
            20                  25                  30          


Ile Met Tyr Met Ile Ile Leu Leu Gly Asn Ser Leu Leu Ile Ile Ile 
        35                  40                  45              


Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Ile Pro Pro 
65                  70                  75                  80  


Met Leu Ile Ile Phe Met Ser Glu Arg Lys Ser Ile Ser Phe Ile Gly 
                85                  90                  95      


Cys Ala Leu Gln Met Val Val Ser Leu Gly Leu Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Ser Ile Ile Met Asn Gly Val Leu Tyr Val Gln Met 
    130                 135                 140                 


Ala Ala Trp Ser Trp Ile Ile Gly Cys Leu Thr Ser Leu Leu His Thr 
145                 150                 155                 160 


Val Leu Thr Met Met Leu Pro Phe Cys Gly Asn Asn Val Ile Asp His 
                165                 170                 175     


Ile Thr Cys Glu Ile Leu Ala Leu Leu Lys Leu Val Cys Ser Asp Ile 
            180                 185                 190         


Thr Ile Asn Val Leu Ile Met Thr Val Thr Asn Ile Val Ser Leu Val 
        195                 200                 205             


Ile Leu Leu Leu Leu Ile Phe Ile Ser Tyr Val Phe Ile Leu Ser Ser 
    210                 215                 220                 


Ile Leu Arg Ile Asn Cys Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ser Ala His Leu Ile Val Val Ile Leu Phe Tyr Gly Ser Ala Leu 
                245                 250                 255     


Phe Met Tyr Met Lys Pro Lys Ser Lys Asn Thr Asn Thr Ser Asp Glu 
            260                 265                 270         


Ile Ile Gly Leu Ser Tyr Gly Val Val Ser Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Val Lys Lys Val 
    290                 295                 300                 


Leu Ser Arg His Leu His Leu Leu Lys Met 
305                 310                 


<210>  34
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gln Gly Glu Asn Phe Thr Ile Trp Ser Ile Phe Phe Leu Glu Gly 
1               5                   10                  15      


Phe Ser Gln Tyr Pro Gly Leu Glu Val Val Leu Phe Val Phe Ser Leu 
            20                  25                  30          


Val Met Tyr Leu Thr Thr Leu Leu Gly Asn Ser Thr Leu Ile Leu Ile 
        35                  40                  45              


Thr Ile Leu Asp Ser Arg Leu Lys Thr Pro Met Tyr Leu Phe Leu Gly 
    50                  55                  60                  


Asn Leu Ser Phe Met Asp Ile Cys Tyr Thr Ser Ala Ser Val Pro Thr 
65                  70                  75                  80  


Leu Leu Val Asn Leu Leu Ser Ser Gln Lys Thr Ile Ile Phe Ser Gly 
                85                  90                  95      


Cys Ala Val Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Ser Ile Ile Met Asn Arg Cys Val Cys Ala Arg Met 
    130                 135                 140                 


Ala Thr Val Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Leu Glu Thr 
145                 150                 155                 160 


Ser Phe Ala Leu Gln Ile Pro Leu Cys Gly Asn Leu Ile Asp His Phe 
                165                 170                 175     


Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Thr Ser Ser Leu 
            180                 185                 190         


Leu Met Asn Thr Ile Met Leu Val Val Ser Ile Leu Leu Leu Pro Ile 
        195                 200                 205             


Pro Met Leu Leu Val Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Ile 
    210                 215                 220                 


Leu Arg Ile Thr Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Gly Ala His Leu Thr Val Val Ile Leu Tyr Tyr Gly Ala Ala Leu Ser 
                245                 250                 255     


Met Tyr Leu Lys Pro Ser Ser Ser Asn Ala Gln Lys Ile Asp Lys Ile 
            260                 265                 270         


Ile Ser Leu Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile 
        275                 280                 285             


Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Met Lys Lys Leu Leu 
    290                 295                 300                 


Gly Lys Ile Thr Leu His Gln Thr His Glu His Leu 
305                 310                 315     


<210>  35
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Leu Met Asn Tyr Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 
1               5                   10                  15      


Pro Gly Ser Glu Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 
            20                  25                  30          


Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Met Ile Val 
        35                  40                  45              


Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 
    50                  55                  60                  


Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Val Met 
65                  70                  75                  80  


Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Tyr Leu Ser Ala 
                85                  90                  95      


Cys Val Val Gln Leu Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe 
            100                 105                 110         


Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Asn Ile Ile Met Asn Arg His Thr Cys Asn Phe Val 
    130                 135                 140                 


Val Leu Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 
145                 150                 155                 160 


Tyr Val Met Phe Gln Leu Thr Tyr Cys Lys Ser Asn Val Val Asn Asn 
                165                 170                 175     


Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr 
            180                 185                 190         


Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe 
        195                 200                 205             


Gly Ser Leu Ile Pro Thr Ile Val Ser Asn Ala Tyr Ile Ile Ser Thr 
    210                 215                 220                 


Ile Leu Lys Ile Pro Ser Ser Ser Gly Arg Arg Lys Ser Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu 
                245                 250                 255     


Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Trp 
            260                 265                 270         


Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe 
        275                 280                 285             


Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Arg Asp Gly 
    290                 295                 300                 


Val Lys Arg Cys Cys Gln Leu Phe Arg Asn 
305                 310                 


<210>  36
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Met Asp Asn His Ser Ser Ala Thr Glu Phe His Leu Leu Gly Phe 
1               5                   10                  15      


Pro Gly Ser Gln Gly Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 
            20                  25                  30          


Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Val Ile Val 
        35                  40                  45              


Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His 
    50                  55                  60                  


Leu Ser Thr Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Met Met 
65                  70                  75                  80  


Leu Trp Gly Leu Leu Phe Leu Gly Cys Arg Gln Tyr Leu Ser Leu His 
                85                  90                  95      


Val Ser Leu Asn Phe Ser Cys Gly Thr Met Glu Phe Ala Leu Leu Gly 
            100                 105                 110         


Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr 
        115                 120                 125             


Asn Ile Ile Met Asn Ser Ser Thr Cys Ile Trp Val Val Ile Val Ser 
    130                 135                 140                 


Trp Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Ile Tyr Ala Thr Phe 
145                 150                 155                 160 


Gln Phe Thr Phe Arg Lys Ser Asn Ser Leu Asp His Phe Tyr Cys Asp 
                165                 170                 175     


Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asn Thr Leu Leu Thr Glu 
            180                 185                 190         


Phe Ile Leu Phe Leu Met Ala Val Phe Ile Leu Ile Gly Ser Leu Ile 
        195                 200                 205             


Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Lys Ile 
    210                 215                 220                 


Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr Phe Ala Ser His 
225                 230                 235                 240 


Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu Phe Leu Tyr Val 
                245                 250                 255     


Lys Pro Lys Gln Thr Gln Gly Val Glu Tyr Asn Lys Ile Val Ser Leu 
            260                 265                 270         


Leu Val Ser Val Leu Thr Pro Phe Leu Asn Pro Phe Ile Phe Thr Leu 
        275                 280                 285             


Arg Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly Met Lys Arg Cys 
    290                 295                 300                 


Cys Gln Leu Leu Lys Asp 
305                 310 


<210>  37
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Arg Asn Gly Thr Val Ile Thr Glu Phe Ile Leu Leu Gly Phe Pro 
1               5                   10                  15      


Val Ile Gln Gly Leu Gln Thr Pro Leu Phe Ile Ala Ile Phe Leu Thr 
            20                  25                  30          


Tyr Ile Leu Thr Leu Ala Gly Asn Gly Leu Ile Ile Ala Thr Val Trp 
        35                  40                  45              


Ala Glu Pro Arg Leu Gln Ile Pro Met Tyr Phe Phe Leu Cys Asn Leu 
    50                  55                  60                  


Ser Phe Leu Glu Ile Trp Tyr Thr Thr Thr Val Ile Pro Lys Leu Leu 
65                  70                  75                  80  


Gly Thr Phe Val Val Ala Arg Thr Val Ile Cys Met Ser Cys Cys Leu 
                85                  90                  95      


Leu Gln Ala Phe Phe His Phe Phe Val Gly Thr Thr Glu Phe Leu Ile 
            100                 105                 110         


Leu Thr Ile Met Ser Phe Asp Arg Tyr Leu Thr Ile Cys Asn Pro Leu 
        115                 120                 125             


His His Pro Thr Ile Met Thr Ser Lys Leu Cys Leu Gln Leu Ala Leu 
    130                 135                 140                 


Ser Ser Trp Val Val Gly Phe Thr Ile Val Phe Cys Gln Thr Met Leu 
145                 150                 155                 160 


Leu Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Ser His Phe Tyr 
                165                 170                 175     


Cys Asp Val Gly Pro Ser Leu Lys Ala Ala Cys Ile Asp Thr Ser Ile 
            180                 185                 190         


Leu Glu Leu Leu Gly Val Ile Ala Thr Ile Leu Val Ile Pro Gly Ser 
        195                 200                 205             


Leu Leu Phe Asn Met Ile Ser Tyr Ile Tyr Ile Leu Ser Ala Ile Leu 
    210                 215                 220                 


Arg Ile Pro Ser Ala Thr Gly His Gln Lys Thr Phe Ser Thr Cys Ala 
225                 230                 235                 240 


Ser His Leu Thr Val Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Met 
                245                 250                 255     


Tyr Leu Arg Pro Thr Ala His Ser Ser Phe Lys Ile Asn Lys Val Val 
            260                 265                 270         


Ser Val Leu Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Thr Ile Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Lys Ala Met Thr 
    290                 295                 300                 


Cys Pro Lys Thr Gly His Ala Lys 
305                 310         


<210>  38
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Asp Arg Gly Thr Ser Asn His Ser Glu Met Thr Asp Phe Ile 
1               5                   10                  15      


Leu Ala Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu 
            20                  25                  30          


Leu Phe Leu Phe Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 
        35                  40                  45              


Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 
    50                  55                  60                  


Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 
65                  70                  75                  80  


Glu Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Asn Lys Ser Ile Ser 
                85                  90                  95      


Phe Ala Gly Cys Val Ala Gln Leu Phe Leu Phe Ala Leu Leu Ile Val 
            100                 105                 110         


Thr Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 
        115                 120                 125             


Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys 
    130                 135                 140                 


Thr Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val 
145                 150                 155                 160 


Ile Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala 
                165                 170                 175     


Val Asp His Phe Tyr Cys Asp Ser Arg Pro Leu Gln Arg Leu Ser Cys 
            180                 185                 190         


Ser Asp Leu Phe Ile His Arg Met Ile Ser Phe Ser Leu Ser Cys Ile 
        195                 200                 205             


Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile 
    210                 215                 220                 


Val Ser Thr Val Leu Lys Ile His Ser Thr Glu Gly His Lys Lys Ala 
225                 230                 235                 240 


Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 
                245                 250                 255     


Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 
            260                 265                 270         


Lys Val Ala Ser Leu Cys Tyr Ser Leu Val Thr Pro Met Leu Asn Pro 
        275                 280                 285             


Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Gln Glu Ala Leu Lys Lys 
    290                 295                 300                 


Phe Leu Glu Lys Lys Asn Ile Ile Leu 
305                 310             


<210>  39
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Phe Pro Ala Asn Trp Thr Ser Val Lys Val Phe Phe Phe Leu Gly 
1               5                   10                  15      


Phe Ser His Tyr Pro Lys Val Gln Val Ile Ile Phe Ala Val Cys Leu 
            20                  25                  30          


Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Phe Leu Ile Ser Ile 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Trp Tyr Ser Ser Ser Ala Leu Ser Pro 
65                  70                  75                  80  


Met Leu Ala Asn Phe Val Ser Gly Arg Asn Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Thr Gln Val Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Pro Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Arg Thr Cys Val Gln Ile 
    130                 135                 140                 


Ala Ala Gly Ser Trp Met Thr Gly Cys Leu Thr Ala Met Val Glu Met 
145                 150                 155                 160 


Met Ser Val Leu Pro Leu Ser Leu Cys Gly Asn Ser Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Ile Leu Lys Leu Val Cys Val Asp Thr 
            180                 185                 190         


Ser Leu Val Gln Leu Ile Met Leu Val Ile Ser Val Leu Leu Leu Pro 
        195                 200                 205             


Met Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ala Ser 
    210                 215                 220                 


Ile Leu Arg Ile Ser Ser Val Glu Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Thr Ala His Leu Met Val Val Val Leu Phe Tyr Gly Met Ala Leu 
                245                 250                 255     


Ser Met His Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys 
            260                 265                 270         


Phe Met Ala Leu Val Tyr Ala Gly Gln Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Leu Lys Lys Leu 
    290                 295                 300                 


Leu Ile Arg Asn His Phe Asn Thr Ala Phe Ile Ser Ile Leu Lys 
305                 310                 315                 


<210>  40
<211>  319
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Met Val Gln Gly Asn Trp Ser Ser Val Thr Val Phe Phe Phe Leu Gly 
1               5                   10                  15      


Phe Ser Gln Tyr Pro Arg Ile Glu Val Thr Ile Phe Val Leu Cys Leu 
            20                  25                  30          


Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Thr Ile Leu Ile Ser Ile 
        35                  40                  45              


Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 
    50                  55                  60                  


Asn Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Ala Leu Thr Pro 
65                  70                  75                  80  


Met Leu Ala Asn Phe Val Ser Gly Glu Asn Thr Ile Ser Phe Ser Gly 
                85                  90                  95      


Cys Ala Phe Gln Met Tyr Phe Ser Leu Ala Met Gly Ser Thr Glu Cys 
            100                 105                 110         


Val Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 
        115                 120                 125             


Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Arg Val Cys Val Gln Ile 
    130                 135                 140                 


Ala Gly Ser Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Val Glu Thr 
145                 150                 155                 160 


Gly Pro Val Ile His Leu Ser Leu Cys Gly Asn Asn Ile Ile Asn His 
                165                 170                 175     


Phe Thr Cys Glu Ile Leu Ala Leu Leu Lys Met Ala Cys Gly Asp Thr 
            180                 185                 190         


Ala Met Val Gln Leu Ile Met Leu Val Ile Ser Ile Leu Leu Leu Pro 
        195                 200                 205             


Leu Pro Met Leu Leu Ile Cys Val Ser Tyr Ala Ser Ile Leu Ser Asn 
    210                 215                 220                 


Ile Leu Arg Ile Ser Ser Val Asp Gly Arg Ser Lys Ala Phe Ser Thr 
225                 230                 235                 240 


Cys Ala Ala His Leu Thr Val Val Val Leu Phe Tyr Glu Thr Ala Leu 
                245                 250                 255     


Ser Met Tyr Leu Lys Pro Leu Ser Val Asn Ser Gln Glu Ile Asp Lys 
            260                 265                 270         


Phe Met Ala Leu Ile Tyr Val Gly Leu Thr Pro Met Leu Asn Pro Ile 
        275                 280                 285             


Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Met Ala Val Lys Lys Leu 
    290                 295                 300                 


Leu Ile Lys Asn Pro Phe Thr Ala Ile Leu Thr Ser Val Leu Lys 
305                 310                 315                 


<210>  41
<211>  960
<212>  DNA
<213>  Rattus norvegicus

<400>  41
atggacagat ccaacgagac ttcccttgtg tcctacttca ttctcctcgg cctctctgcc       60

cacccaaggc tggagaaaac cttcttcgtg ctcatcctgc tgatgtacct ggtgatcctg      120

ctgggcaatg gggtccttat cctggtgacc atcctcgact cccacttgca cacgcccatg      180

tacttcttcc tggggaacct ctccttcctg gacatctgct acaccacttc ctcaatcccc      240

ttggtcctgg atggttttct cacccccagg aagaccatct ccttctcagg ctgtgccatg      300

cagatgtttc tgtccttcgc catgggagcc acagagtgtg tgctcctggg catgatggcg      360

tttgatcgct atgtggccat ctgcaacccc cttaggtacc cagtggtcat gagcaaggct      420

gcctatgtcc ccatggccgc cggctcctgg gcagggggaa gcatcactgc cacagttcag      480

acatctttag caatgcggct gccattctgt ggggacaacg tcatcaacca cttcacctgt      540

gagatcctgg ctgtcctgaa actggcctgt gccgacatct ccatcaatgt catcagcatg      600

gcggtaggta atgcagtatt tttgggggtc ccagtcctgt tcatctttgt ctcctacatc      660

ttcatcctct ccaccatcct gaggatcccc tctgctgagg ggaggaagaa ggccttctcc      720

acctgctctg cccacctcac tgtggtgatt gtcttctatg ggaccatcct cttcatgtac      780

gggaagccca aatccaagga cccactgggg gcagacaagc aggaccttgc agacaagctc      840

atctccctct tctatggggt gttgaccccc atgttgaacc ccatcatcta cagcctgagg      900

aacaaggacg tgagggccgc tgtgaggaac cttctacatc agaaacactt caagtggtga      960


<210>  42
<211>  948
<212>  DNA
<213>  Rattus norvegicus

<400>  42
atggaaagta gcaaccagac ctcccccgtg tcccgcttca ttctcctggg cctctctgcc       60

cacccaaccc tggagaaaac cttcttcgtg ctcatcctgc tgatgtacct ggtgatcctg      120

ctgggcaacg gggtcctcat cctggtgacc atcctcgact cccacctgca cacgcccatg      180

tacttcttcc tggggaacct ctccttcctg gacatctgct acaccacctc ctcggtcccc      240

ctcattctgg acagcttcct gacccccagg aagaccatct ccttctcagg ctgtgccgtg      300

cagatgtttc tgtctttcgc catgggagcc acggagtgtg tgctcctgag catgatggcg      360

tttgatcgct atgtggccat ctgcaatccc ctcagatacc cagtggtcat gagcaaggct      420

gtctatgtcc ccatggccac cggctcctgg gcagctggaa ttgcagcctc tctggttcaa      480

acatcccttg caatgcggct gcccttctgt ggggacaacg tcatcaatca ctttacctgt      540

gagatcctgg ctgtcctgaa actggcctgt gctgacatct ccatcaatat catcagcatg      600

ggggtgacaa atgtaatctt cctgggggtc ccagttctct ttatttcttt ctcctacata      660

ttcatcctct ccaccatcct gaggatcccc tctgctgagg ggaggaagaa ggcattctcc      720

acctgctctg cccacctcac tgtggtgatt gtcttctatg ggaccatcct cttcatgtac      780

gggaagccca agtccaagga cccactgggg gcagacaagc aggaccttgc agacaagctc      840

atctccctct tctatggggt gttgaccccc atgttgaacc ccatcatcta cagcctgagg      900

aacaaggacg tgagggccgc tgtgaggaac ctggtggtcc ttaagtaa                   948


<210>  43
<211>  957
<212>  DNA
<213>  Rattus norvegicus

<400>  43
atggaaatag ccaaccagtc cacggtagct gagtttgtct tgctgggatt gtcagaccac       60

ccaatgctgg agaaaacctt cttcgtgctc atcctgctga tgtacctggt gatcctgctg      120

ggcaatgggg tccttatcct ggtgaccatc ctcgactccc acctgcacac gcccatgtac      180

ttcttcctgg ggaacctctc cttcctggac atctgctaca ccacttcctc aatccccttg      240

gtcctggatg gttttctcac tcccaggaaa accatctcct tctcaggctg tgccatgcag      300

atgtttctgt ctttcgccat gggagccacg gagtgcgtgc tcctgggcat gatggcgttt      360

gatcgctatg tggccatctg caaccccctt aggtaccccg tggtcatgag caaggctgcc      420

tatgtgccca tggccgtcag ctcctgggtg gctggcggtg ccaactccat ggtgcagatc      480

tcccttgctg tgcagttgcc tttctgtggg gacaatatca tcaaccactt cacctgtgag      540

attttggcag tcttaaagct agcctgtgct gacatctcca tcaatgtcat cagcatgggg      600

gtggccaacg tgatcttcct gggggtccca gttctgttca tctttgtctc ctatatattc      660

atcctctcca ccatcctgag gatcccctct gctgagggga ggaagaaggc attctccacc      720

tgctctgccc acctcaccgt ggtgattgtc ttctatggga ccatcctctt catgtacggg      780

aagcccaagt ccaaggaccc actgggggca gacaagcagg accttgcaga caagctcatc      840

tccctcttct atggggtgtt gacccccatg ttgaacccca tcatctacag tctgaggaac      900

aaggacgtga agactgctgt aagagacctg gtgggtcgaa aatgcctaat tcagtga         957


<210>  44
<211>  957
<212>  DNA
<213>  Rattus norvegicus

<400>  44
atggaagtgt ccaaccagtc cactgtgaca gaatttgtcc tattgggcct ctctgcccac       60

ccaaccctgg agaaaacctt cttcgtgctc atcctgctga tgtacctggt gatcctgctg      120

ggcaatgggg tcctcatcct ggtgaccatc cttgactctc acctgcacac gcccatgtac      180

ttcttcctgg ggaacctctc cttcctggac atctgctaca ccacctcctc ggttcccttg      240

gtcctggatg gttttctcac ccccaggaag accatctcct tctcaggctg tgccgtgcag      300

atgtttctgt ctttcgccat gggagccacg gagtgcgtgc tcctgggcat gatggcgttt      360

gatcgctatg tggccatctg caaccccctt aggtaccccg tggtcatgag caaggctgcc      420

tatgtgccca tggccgtcag ctcctgggtg gctggcggtg ccaactccat ggtgcagatc      480

tcccttgctg tgcagttgcc tttctgtggg gacaatgtca tcaatcattt catttgtgag      540

attttggcag tcttaaagct agcctgtgct gacatctcca tcaatgtcat cagcatgggg      600

gtggccaacg tgatcttcct gggcgtccca gttctgttca tctttgtctc ctacatcttc      660

atactctcca ccatcctgag gatcccctct gctgagggga ggaagaaggc attctccacc      720

tgctctgccc acctcactgt ggtaatcatt ttttatggta ccatcctctt catgtacggg      780

aagcccaagt ccaaggaccc actgggggca gacaagcagg accttgcaga caagctcatc      840

tccctcttct atggacttct gactcccatg ttgaacccca tcatctacag cctgaggaac      900

aaggatgtga agactgctgt aagagacctg gcaagtcaca gatgtctcac ccagtaa         957


<210>  45
<211>  960
<212>  DNA
<213>  Rattus norvegicus

<400>  45
atggacaggt tcaatgagac ctcccccgta tcccacttca ttctcctggg cctctccgcc       60

cacccaaggc tggagaaaac cttcttcgtg ctcatcctgc tgatgtacct ggtgatcctg      120

ctgggcaacg gggtccttat cctggtgacc atcctcgact cccacctgca cacgcccatg      180

tacttcttcc tggggaacct ctccttcctg gacatctgct acaccacctc ctcggtcccc      240

ctcattctgg acagcttcct gacccccagg aagaccatct ccctctcagg ctgtgccgtg      300

cagatgtttc tgtccttcgc catgggagcc acggagtgtg tgcttctgag catgatggcg      360

tttgatcgct atgtggccat ctgcaacccc cttaggtacc cagtggtcat gagcaaggct      420

gcctatgtgc ccatggccgc cggctcctgg gcaggtggta tcaccaattc tgtagttcag      480

acatctttgg caatgaggct gccgttctgt ggggacaatg tcatcaacca cttcacctgt      540

gagatcctgg ctgtcctgaa actggcctgt gctgacatct ccatcaatat catcagcatg      600

ggggtggcca acgtgatctt cctgggggtc ccagttctgt tcatctttgt ctcctacatc      660

tttatcctct ccaccatcct gaggatcccc tctgctgagg ggaggaagaa ggcattctcc      720

acctgctctg cccacctcac cgtggtgatt gtcttctatg ggaccatcct cttcatgtac      780

gggaagccca agtccaagga cccactgggg gcagacaagc aggaccttgc agacaagctc      840

atctccctct tctatggggt ggtgaccccc atgttgaacc ccatcatcta cagcctgagg      900

aacaaggatg tgagggctgc tgtgaggaac ctggtggttc agaaacacct aactgagtga      960


<210>  46
<211>  960
<212>  DNA
<213>  Rattus norvegicus

<400>  46
atggtacagg gaaattggtc ctctgtcaca gtgtttttct tcctgggatt ttctcagtac       60

cccagaattg aagtcaccat atttgtgctg tgtctgctga tgtacctgat caccttgctg      120

ggaaatacta ttctgatctc catcactatc cttgattctc acctgcacac tcccatgtac      180

tttttcctta gcaacctctc ctttctggac atctggtata cctcttctgc tctcactcct      240

atgctggcaa actttgtttc aggggaaaac accatctcat tctcaggatg tgctttacag      300

atgtacttct ctcttgccat gggctccacg gaatgtgtgc tcctctctat gatggcctat      360

gacaggtatg tggccatctg caaccccctg agatatccca tcattatgaa caggagggtc      420

tgtgtacaga ttgcaagcag ctcctgggct acaggctgcc tcactgcctt ggtggaaact      480

ggacctgtga ttcatctgtc tctctgtggt aataacatca tcaatcattt cacctgtgaa      540

attctggctc tcttaaaaat ggcttgtgga gacactgcca tggtgcagtt aattatgtta      600

gtgatcagca tccttcttct cccattgcca atgttgctca tttgtgtctc ctatgcatcc      660

atcctctcca acatcttgag gatcagctca gtggatggcc gaagcaaagc cttttcaaca      720

tgtgcagccc acttgactgt ggtggttctg ttctatggga cagctctctc catgtacctg      780

aagccctcat ctgtaaactc acaggaaata gataaattta tggcattgat atatgctgga      840

ctaacaccaa tgctaaatcc tattatctac agtctacgga acaaagaagt caaaatggct      900

gtgaaaaaat tgttgattag aaatcccttc agtactatct taacttctgt cctcaaataa      960


<210>  47
<211>  924
<212>  DNA
<213>  Rattus norvegicus

<400>  47
atggcaccaa taaaccagtc agttgtgacc atgttcttcc tgcaaaactt tgttgatgat       60

ccctggatcc agaatgttct cttttgcttt ttctttgcct tgttcgtggc agccatagct      120

ggcaatggcc tgattatcac agtcattcac agcagtgcca acctccacac tcccatgtac      180

ttcttcctag tcaatctttc cctcatggat gtgatttgca ctgtgacagt gttgcccaaa      240

gtcctgcaga gcctggtggc agagaacgcc atttcttatg ggggatgtct cacacagatg      300

tttgtcttct cctgggttct gggctctgag cttctgcttt tctctgccat ggcctacgac      360

cgctaccttg caatctgccg gccattgcac tatggtaccc tcatgagtgg cagggtctgc      420

atagcccttg caacctttgt gtggttcact ggagctctca attccttggt gctcacttgt      480

ctggtgttgc cactgtcctt ctgtggtccc aatctcatca cacacttctt ctgtgagatc      540

ccttctgtgt tgatgctgtc ctgcagcccc acctttatca atgacatcat gactgtcatt      600

gcagacatgt tccttacagg actgaacttc ctattgacta tgacatccta tggctttatc      660

attgccagca tcctgcgcat ccgctctgct gagggcaaga agcgtgcctt ctctacctgc      720

tctgcccacc tggttgtggt caccctttat tattctactg ttctatatac ttatgtccgg      780

ccagccctag gaacttctgg gctcctggac aaagtcattg ctgttctgta taccactgtg      840

accccatctc tgaacccact catctatacc ctgagaaaca aggaattcaa aacatccttt      900

aaaaaactct tatttcccaa ttga                                             924


<210>  48
<211>  936
<212>  DNA
<213>  Rattus norvegicus

<400>  48
atggacagtt tcaatgccac tttagaagag agattcattt tggtgggctt ttcagattgg       60

cctcagctgg aactcatcct ttttgttttt atttcaattg tctactccct aactctcttt      120

ggcaacaccg ccatcatagc tctctcccga atggaccttc gattacacac ccccatgtac      180

ttcttcctct cacacctctc cttcctggac ctctgctaca ccaccagcac cgtgccccag      240

ctcctgatca acctgcatgg acttgacagg atcatcagct atggaaggtg tgtggcccag      300

ctgtttatat ctcttgctct gggatccact gagtgtgtgc tcctggtggt gatggctttt      360

gaccgctatg ctgctgtgtg tcgtccactg cactacacga ccatcatgca ccctgttctc      420

tgccaggcat tggccattgc ttcctgggta ggaggcttct tgaactctct gattcaaaca      480

ggactcatga tgaccatacc gctctgtgga cgccgactaa atcatttctt ctgtgagatg      540

cctgtgttcc tcaagttagc ctgcaaggac acaggagata cagaggccaa gatgtttgtg      600

gccagagcca taatcttggt cttccctgca acattaattc ttggctccta tggacacatt      660

gctagagcag tattgaaggt aaagtcaatg gctggccgca gaaaggcttt tgggacatgt      720

gggtcccacc tcctggtggt ttccctgttt tatggctcag ccatttacac atacttgcaa      780

cccaagggta gttattctga gagtgatgga aagtttgttg ccctttttta tactatagtg      840

actcccatgc tcaacccttt gatctatacc ctgaggaaca aggatgtgaa gggcgctctg      900

tggaaggtgc tagggaggag cacaggccaa gagtag                                936


<210>  49
<211>  918
<212>  DNA
<213>  Rattus norvegicus

<400>  49
atgatgaatg ggacactggt cactgagttc ttcatcctgg gattctcaga aatgcctcac       60

cttcgggtac cacttctcct cagcttcttc tgcctataca tggctgcaat ctcaggaaac      120

ctgcttatta tggtgacaat cagtgccagc ccagccctgc atacccctat gtacttcttc      180

ctggtcaact tggccatggt ggatatcctc tgcacctcca ccatcctacc aaagctactg      240

gacagcatga tggcagggag gagcatctct tatgggggct gcatggccca gctcttcttc      300

ttcacatggt ccctgggggc agagcttctg ctcttctcag ctatggccta tgaccgcttc      360

gtggccatct gctgtcccct gcactacagt gcttggatgg gccctagggt atgtgcattc      420

ctggctggcc ttgtctggtc catcagcata actaacacca gcgtgcacac aggactgatg      480

ttgcgtctac cattctgtgg ctccaatgag atagagcact tcttctgtga gattccccca      540

ctgttgaaac tctcctgtgc tccaacacaa ttgaatgagg ccatggcctt tgctgcagat      600

gtgttcctgg ctgtagggaa cttctctgtg acaatcctct cctatggctt tattgtggtt      660

agtatcctga ggatccgttc agctgaaggc aagcgacgtg ctttttctac ctgctctgca      720

cacctcattg tggtcaccat gtactactcc actgtcatct atacctacat tcgccctgca      780

tccagctact cactgaacaa ggataaggtg gtgtccatca tctacacctc ggtggcaccc      840

accttgaacc ccctcatcta cactctgaga aacaaggatg tcaaagttgc actccggaga      900

cttctatcct gctcctga                                                    918


<210>  50
<211>  954
<212>  DNA
<213>  Rattus norvegicus

<400>  50
atggacagcc ccagcaatag caccatatcc cgtggctttc tccttcaagg cttttttgag       60

tttccgcatc tgaggcccct tctcttcctg gtgctgctgg ctgtgcacct ggccactttg      120

agtggtaacc tgctcatcct ggtggctgtg gtctcagtgc ccagcaggcc acccatgctg      180

ctcttccttt gtcagttgtc agccattgaa ctctgttaca cgctagtggt ggtgccccga      240

tctctagccg acctgagcat gcctggccat ggcaggggca gccccatctc cttcctgggc      300

tgtgctgtcc agatgcagat gtttgtggca ctgggtgggg ctgagtgctt cttgttggca      360

gccatggcct atgaccgcta tgtggccatc tgccacccac tgcgctatgc atccattgtg      420

accccaggtc tatgtgcacg actggccctg gcctgctgcc ttggcggact agctgtatcc      480

gtgggactaa cggtggcagt gttccacctc cctttctgtg gctcccgcct gctggtgcat      540

ttcttctgcg acatcaccgc cctgctgcac ttggcctgca cacggagcta catagatgag      600

ctgcccttgc taggagcctg cctggtgctg ctgttgctgc cctcaatgct catcctgacc      660

tcctatgggg ccattgcctc tgccctgcgc cgcctgcatg gtggtggagg cagacgcaag      720

gctgcctcga cctgtgcttc acacctggct gtcaccttct tgcattacgg ctgtgccacc      780

ttcatgtacg tgcggcccaa gtccagttac tccccgcgac tggatcgcac actagcgctg      840

gtttatacca acgtcacacc acttctatat cctctcatct acagcctgcg caaccgggag      900

atcacttctg ccattcacag agtcctgggg ctccgtggat cagggtctat gtga            954


<210>  51
<211>  927
<212>  DNA
<213>  Rattus norvegicus

<400>  51
atgggatatg ggaacatcac agaatttatc ttactggggc ttttccatga tgaggatgtc       60

aaggcaatat gtgctgtgtt attcttacta tgctatcttg caattctctg tggaaacttg      120

attgttcttc tcactatcaa gggcagtcag cttagtgagc agccgatgta cttttttctc      180

agctatctgt ctttcatgga tgtctgcttc acttccacag tagccccaaa atttattata      240

ggactattgg tacaatgtaa cacaatctcc tacaatgcct gcatagcaca aatgttttat      300

gcccacttct ttggtgccac tgagatattt atattggtgg tcatggccta tgatcgctat      360

gtagcaattt gcagacctct ttactacatg atcacgatga gcagacaggt atgctacatt      420

cttgtgatag gctcagtttt tggtgctttt atacactcac ttgtgcatgt attagttatt      480

atcagacttc ctttttgtgg caccaatgaa atagaccact acttctgtga catattccct      540

ctgctgaagc tggcctgcac tgagacaaga ctccttgtta ttgtaatcat taccactaca      600

ggggtgatgt ccattttgac ttttgttgca ttggtaattt cttacatcat cattttgtcc      660

atcttgagga ccaggtcatc ggaaggccgt cgcaaagctc tttctacctg tggctcacat      720

atcaccgtag tgttcatgtt cttcttgcca ctcatcttta cctatgttcc aatgggtgat      780

tctgttgggg atgacaaggt gtttgctctg ttttacacca tgattgcacc attgttcaac      840

cctctcatct acacactgag gaatacagac atgaagaatg ccatgaggaa ggtgtggtgc      900

caagacaaac tgtttgaagg aaagtga                                          927


<210>  52
<211>  939
<212>  DNA
<213>  Rattus norvegicus

<400>  52
atgaatgaaa taaattacac caaggtttct gaatttgtgt ttctgggact ttcaaaatct       60

aaagaaatac aacatttctt ccttgccttc tctgtggtat tatatgtagc catcgtactg      120

ggcaataccc ttgttgtgtt tacactagca ttggacccac atttacattc ccctatgtat      180

tttcttttag gaaacctctc atttattgat ttatgttttt ccaccttaac tgtacccaag      240

atgatttctg acttgtcgtc tgggcacaat accatctcat tccatggttg tgtcttccag      300

atatttgtca ttcatgtcct tggggcttct gagatggtat tgctggtagt catggcctgg      360

gacagatatg tagccatatg taaacccctc cactatttaa ccatcatgaa cccacggatt      420

tgcattttgc ttctatctgg ggcttggatt attgcatttt tgcattcagt gatccaactt      480

ggttttgttg tccatttgag gttttgtggt ccgaatgaga tagatagttt ttactgtgat      540

cttcctagat tcatcaagct ggcctgcatg gacaactaca gaatggagtt catggtggct      600

gccaacagtg gcatcatttc tattggcacc ttcttcttat tgattatctc ctacattgtt      660

atcctgctca ctgtgaggaa acattcatca ggagatttgt ccaaggccct ctcgacactt      720

tctgctcaca tctctgtggt agttttgttc tttggaccat gcatctttgt atacatgtgg      780

ccatttccta cagtgccagt ggataagttc cttgccattc tggacttcat gattacaccc      840

atcctgaacc ctgccattta cacactgagg aacaaagaca tgaaggtggc aatgaggaaa      900

ctaagtgttc agctcctgca ttttaggaaa atgtcctga                             939


<210>  53
<211>  927
<212>  DNA
<213>  Rattus norvegicus

<400>  53
atgagcctct cagacaatcc agaactgcag cctatccttt ttgtactgtt tttatcattc       60

tacatggtca cagtgcttgg aaatctgctc attattctgg ctgtgagctc tgacttccat      120

ctccataccc ccatgtattt ctttctctcc aacctttcct ggtctgacat ttgtttgatc      180

tccactacag ttccaaagat gatttgggat attagaactc aaagcagagt catctcctat      240

gcgggctgcc taacacagat gtccatgttc ataatttttg gatgtatgga tagcatgctt      300

ctgactgtaa tggcctatga caggtttgtg gccatttgtc accccctgaa ttacaatatc      360

attatgaatc ctaacctctg tgccctctta cttttggcat ctgtattggc cagtcttgtg      420

gattcgcagg tgcacaattt gattgtgcta caatttacat acttcaatga catggaaatc      480

tctaactttt tttgtgagcc ttcacaactg cttaatctca agtgttctga aatgttcacc      540

aaaaacatag ttatacgatt cattggtgtc ttttttggtt tattttcaac ctcaggaatt      600

attttctcat actataaaat tgtgtcttcc atcctgagaa ttccatcaac agaaggaaag      660

tataaagcct tttctacctg tgtgtctcac ctgtcagttg tgtgcttatt ttatggaaca      720

gccattggag tatacattgg ttcaactgca tcaaactctt ctgaaaactg taaagttgct      780

tcactgatgt acacagtggt cacacctatg cttaatccct tcatctacag cctgaggaac      840

agggacatta aaactgccct atggaaacta cagaaaaaag caaaattgca caatgccttc      900

catcattttt taattttgag ttcttaa                                          927


<210>  54
<211>  942
<212>  DNA
<213>  Rattus norvegicus

<400>  54
atgagcagca ccaaccattc cagtgtctca gtgttcctcc tcctgggact ctccaggcag       60

ccccagcagc agcagctcct cttcctgctc ttcctcatca tgtacctggc cactgtcctg      120

ggaaacctgc tcatcatcct gtccatcagc acagactccc gcctgcacac ccccatgtac      180

ttcttcctca gcaacctgtc ctttgtggat ctctgcttct cctccaccac tgtccctaaa      240

gtactgacca accatatact tgggagtcag gaaatttcct tctctgggtg tctcacacag      300

atgtattttc tctctgtgtt tgctgatatg gacaattttc tgctggctgt aatggcctat      360

gaccgatttg tggccatatg ccacccttta cactacacaa aaaagatgac ccatcagctg      420

tgtgcccttc ttgttgttga gtcatggctg gctgtcaatc tgaatgctct tttacataca      480

ctgctaatgg ctcgactttc tttctgtggg gacaacctca taccccacta tttctgtgat      540

gcaactcctc tcctgaaact ctcctgctca gacacacatc tcaatgagct aatgattaat      600

acagagggag ctgtgaccat ggtcacccca tttgtctgca tcctgatctc ctacatccac      660

atcacctgtg ctgtcctgag agtctcatcc cccaggggag gatggaaagc cttctccacc      720

tgtggctccc acctggctgt ggtctgcctc ttctatggca ccatcatcgc tgtgtatttc      780

aatccctcaa ctgcccattc acctgagaag gacacagtag ccactgtgtt gtacacagtg      840

gtgactccca tgctgaaccc ctttatctat agcctgagga acagggacct gaaatggtca      900

ctacgaaaac ttgtccatag aagtaccttt tcttttcagt ga                         942


<210>  55
<211>  948
<212>  DNA
<213>  Rattus norvegicus

<400>  55
atgatgaagg caaatcactc tttagagttc attctcatag gattcacaga tcacccagac       60

ctaaagacac ttctgttcct ggtgttctct gccatatatc tggtcaccat ggtggggaat      120

cttgggctgg tggccttgat ctacatggag cctcgtttcc acacacccat gtacatcttt      180

ctgggaaacc tggccctgat ggactcctgc tgctcctgtg ccatcactcc caagatgcta      240

gagaacttct tttctgtgga cagaaggatc tctttctgtg aatgcatggc acagttctat      300

ttcctctgtc ttgctgaaac tgcagactgc tttcttctgg cagccatggc ctatgaccgc      360

tatgtggcca tatgcaaccc actgcagtac cacaccatga tgtccaagaa gctctccctt      420

cagatgagca tgggcatatt catagccagt aacctgcatt ccttgattca tacaggctgt      480

ctgttaagat taaatttctg taaatctacc aaaattgatc acttcttctg tgatattctt      540

cccctgtatc gcctctcctg tacaaaccct tttattaatg aactaatgat atatattttt      600

tcaatgccaa ttcaagtctt taccattacc actatcttgg tctcttactt ctgcattctt      660

ttcactattt tcaagatgaa atccaaggat gggagaggaa aagcattttc tacttgtgca      720

tcccattttt tttctgtgtc aatattctac acctgtcttc tcatgtatat tggaccatct      780

gaagatggta gtaaagacat accagtagct gtgttttata cagtaataat tcctttgtta      840

aaccctttta tttacagcct gagaaataag gaggtagtaa atgctgttaa gaaagttatg      900

aaaacttaca gtatttttaa aaatgcttct gcttccatag tacattaa                   948


<210>  56
<211>  951
<212>  DNA
<213>  Rattus norvegicus

<400>  56
atggtaccaa tggaaagaaa tgtgagtgtg gagattatct ttgtcctggt gggcttcaca       60

gactaccctg agcttcagat ccccctcttc ctagtctttc tcttcatgta catcatcact      120

gtagtgggga accttgggat gatagtgctc atcaatatcg accccaagtt ccacactccc      180

atgtactttt tccttagcca cctttccttt gttgatttct gttatccaac aattatcatg      240

cccaagctgc ttgagaactt gatcctggct gataaaacta tactttattt cagctgcatg      300

ctgcagtact tcctgtcctg tgtggctgtg gtggctgagt cctacttgtt agcagttatg      360

gcctatgacc gctttgtggc catctgtaat cccttgctgt atactgtggc catgtcacag      420

agactgtgca tcctgcttgt gactggatca tatatctgga gcacattggc caccttgatt      480

ctcctctgct atgctctgca gctaaagttc tcaagattta ctgtgatcaa ccacttcttc      540

tgtgaatata ctgccctcat tgctgtctct agttctgata tacacatccc cagcctacta      600

ctcttttgtt ttgcaacctt taacgaagtg agtaccctac tgatcattct cacttcttac      660

gtgttcattt ttgtgactgt gttaaaaatc aaatctgcta gtggacgtcg caaagccttc      720

tctacctgtg cctcccacct gactgccatc accatttttc atggaaccat actttctctg      780

tactgtgtac ctaacccaca aaattctagg aatgcagtca aagtggcctc tgtcttttac      840

gcagttgtca accccttgct taaccctctt atctacagtc tgagaaacaa ggatgtgaaa      900

gaggttttac agaaagtagt gagcacttca ttgaaattcc cacttcactg a               951


<210>  57
<211>  954
<212>  DNA
<213>  Rattus norvegicus

<400>  57
atgggacaga gcaacaatgt cacagaattt gtcctgctgg gcttcactca ggatcctgct       60

gggcaaaaag ctttatttgt tatgttttca ctgatgtaca ttgcaacaat ggtgggcaac      120

ctgctcattg tagggacagt gattgtcagc ccctccttag gctccccgat gtacttcttc      180

cttgcctctc tgtcactcat ggatgctgtt tattctactg ccatctcacc caagttgatt      240

gtagacttgc tccgtgagaa aaagaccatc tccttcagag cttgcataag ccagctcttt      300

atagagcatt tatttggcgg ggttgacatt gttattctgg tggcaatggc ctatgatcgc      360

tatgtggcca tctgtaagcc actacattat ttgaccatca tgaatcgacg ggtatgtatt      420

ctcttcttgg tgatggcctg ggcaggaggt tttgcacatg ctttgtttca agttcttgct      480

gtatataatc ttcctttctg tggtcccaat atcattgacc actttgggtg tgacatatac      540

ccgctcttgc tacttgcatg tactgacacc tacttcattg gactttctgt cattggcaat      600

aatggggcca tgtgtatagt catctttagt ctccttctat tttcctatgg aataattctt      660

agatctctcc agaatcacag tcaggaaggg aggcgcaaag ctctgtccac ctgcagctct      720

catatcactg tggtttttct cttttttgtt ccctgtattt tcatgtatgt tagacctgtt      780

tctagttttc ctattgacaa atccatcact gtaatttata ctgttgtcac ccccatgttg      840

aatcctttaa tatatacttt gagaaattca gagatgaaaa attctatgga aaagctcctg      900

cagaaaatat taagtccaaa tagactaagg cttctttgct gcttacatta ttaa            954


<210>  58
<211>  930
<212>  DNA
<213>  Rattus norvegicus

<400>  58
atggaaacat ataatttaac aggaaccttg gaatttcttc tgcttgatct gtcagaggac       60

actgaactgc agttcatctt ctttgtattg ttcctgctca tatacctgct cactgtactt      120

ggaaatgtgc tcatcatctt ggccattagc tctgattctc agctccatag tcctatgtac      180

tttttcctct acaacctttc attgtctgac atgggcttca gcagcaccac agtccccaaa      240

atgctgataa atatgcagac tcacaacaaa tccataactt atgcaggctg cttaactcag      300

gtattcttct tcattctttt tgggggtatg gacagcctat tactgactgc aatggcctat      360

gaccgatggg tagccatttg tcaccctcta cactaccaag tcattctcaa ccctcgtctg      420

tgtagatgtt tgctcatact ttcatttttc attagtgttt tgagttcaca ggtacactgc      480

ttgatggtgt cacaattaac attttgcact aatatggaaa tccatcattt cttctgtgat      540

gttccagaac ttctaaaact ttcctgttct gactccttta tcagtaacat agttaggatt      600

attttaagca tcattcttgg tttcctaccc atgtcaggaa tactttattc ctactataaa      660

ataacttcct ccatttttaa atttccatca ctgttaggga aatataaagt cttctctact      720

tgtggatctc acctatcagt tgtttgctta ttttatggaa caggtatagg tgtgtacctt      780

agttcaacag tttctagttc ttacggggaa agcatggtgg cttcggtact atatatcatg      840

gtggttccca tgataaaccc cttcatctac agcctgagga acaaggacat caaaaaagcc      900

cttcagaaaa ttgtcagaca aatattgtag                                       930


<210>  59
<211>  960
<212>  DNA
<213>  Mus musculus

<400>  59
atggacagat ccaatgagac cgcccccctg tccggcttca ttctcctggg cctctctgcc       60

cacccaaagc tggagaaaac cttcttcgtg ctcatcctga tgatgtacct ggtgatcctg      120

ctgggcaacg gcgtcctcat cctggtgagc atcctcgact cccacctgca cacgcccatg      180

tacttcttcc tggggaacct ctccttcctg gacatctgct acactacctc ctctgtcccc      240

ctcattctgg acagctttct gactcccagg aagaccatct ccttctcggg ctgtgccgtg      300

cagatgtttc tctccttcgc catgggagcc acggagtgtg tgctcctgag tatgatggcg      360

tttgatcgtt atgtggccat ctgcaacccc cttagatatc ctgtggtcat gaacaaggct      420

gcctatgtgc ccatggctgc cagttcctgg gcaggtggta tcactaattc tgtagtgcag      480

acatctttgg caatgcggct gcccttctgt ggggacaatg tcatcaatca cttcacctgt      540

gagatcctgg cagtcctgaa actggcctgt gctgacatct ccatcaatgt catcagcatg      600

gttgtggcca acatgatctt cttggcagtc ccagtcctct tcatctttgt ctcctatgtc      660

ttcatccttg tgacaatcct gaggatcccc tctgctgagg ggaggaagaa ggcattctcc      720

acctgctctg cccacctcac cgtggtactt gtcttctatg gaaccatcct cttcatgtac      780

gggaagccca agtccaagga cccactgggg gcagacaagc aggaccttgc agacaagctc      840

atctccctct tctatggagt ggtgaccccc atgctaaacc ccatcatcta cagcttgaga      900

aacaaggacg tgagggctgc tgtgaggaac ctggtgggcc agaaacacct aactgagtga      960


<210>  60
<211>  957
<212>  DNA
<213>  Mus musculus

<400>  60
atggaaggag ccaatcagtc tacggtagct gaatttgtct tgctggggtt gtcagatcac       60

ccaaagctgg agaaaacctt cttcgtgctc atcctgctga tgtacctggt gatcctgctg      120

ggcaacggcg tcctcatcct ggtgagcatc ctcgactccc acctgcacac gcccatgtac      180

ttcttcctgg ggaacctctc cttcctggac atctgctata ctacctcctc gattccctta      240

gtcctggatg gttttctcac ccccaggaag accatctcct tctcgggctg tgccgtgcag      300

atgtttctct cctttgccat gggagccacg gagtgtgtgc tcctgggcat gatggcgttt      360

gatcgttatg tggccatctg caaccctctt agataccctg tggtcatgaa caagtctgcc      420

tatgtgccca tggccgtcag ctcctgggtg gctggcggtg ctaactcctt ggtgcagatc      480

tcccttgcgg tgcagttgcc tttctgtggg gacaatgtca tcaatcactt cacctgtgag      540

atcctagcag tcttaaagct agcctgtgct gacatctcca tcaatgtgat cagcatgggg      600

gtggccaatg tgattttcct gggggttcca gttctgttca tctttgtctc ctacatcttc      660

atactctcca ccatcctgag gatcccctct gccgagggga ggaagaaggc attctccacc      720

tgttctgccc acctcaccgt ggtacttgtc ttctatggga ccatcctgtt catgtacggg      780

aagcccaagt ccaaggaccc attgggggca gacaaacagg atgtttcaga caagctcatc      840

tccttatttt atggggtgct gacccccatg ctgaacccca tcatctacag cctgaggaac      900

aaggatgtga aggccgctgt gaggaacctg gtaggtcaga aatgcctgat tcagtga         957


<210>  61
<211>  957
<212>  DNA
<213>  Mus musculus

<400>  61
atggatgtat ccaaccagac gactgtaaca gaatttgtcc tgttgggcct ctccgcccac       60

cccaaactgg agaaaacctt cttcgtgctc atcttgtcaa tgtacctggt gatcctgctg      120

ggcaacgggg tcctcatcct ggtgagcatc ctcgactccc acctgcacac gcccatgtac      180

ttcttcctgg ggaacctctc cttcctggac atctgctaca ccacctcctc cgttccctta      240

gtccttgatg gttttctgac ccccaggaag accatctcct tctcgggctg tgccgtgcag      300

atgtttctct ccttcgccat gggagccaca gagtgtgtgc tcctgggcat gatggcgttt      360

gatcgttatg tggccatctg caaccccctt agataccctg tggtcatgaa caaggctgcc      420

tatgtgccca tggccgtcag ctcctgggtg gctggcggtg ctaactcctt ggtgcagatc      480

tcccttgcgg tgcaattgcc tttctgtggg gacaatgtca tcaatcattt catctgtgag      540

atcctggcag tcttaaagct agcctgtgct gacatctcca tcaatgtgat cagcatgggg      600

gtggccaatg tgattttcct gggggttcca gttctgttca tctttgtctc ctacatcttc      660

atactctcca ccatcttgag gatcccctct gctgagggga ggaagaaggc attctccacc      720

tgctctgccc acctcaccgt ggtgatcatt ttttatggga ccatcctctt catgtacggg      780

aagcccaagt ccaaggaccc actgggggca gacaagcagg accttgcaga caagctcatc      840

tccctcttct atggactgct gacccccatg ctgaacccca tcatctacag cctgaggaac      900

aaggacgtga aggccgctgt gaggaacctg gcaagtcaca gatgcctcac cttctaa         957


<210>  62
<211>  960
<212>  DNA
<213>  Mus musculus

<400>  62
atggaaagat ccaacaagac cacccctgtg tccagcttca tcctcctggg tctctccgcc       60

cacccaaagc tggagaaaac cttcttcgtg ctcatcctgc tgatgtacct ggtgatcctg      120

ctgggcaatg tcgtcctcat cctggtgagc atcctcgact cccacctgca cacgcccatg      180

tacttcttcc tggggaacct ctccttcctg gacatctgct acaccacctc ctccgtcccc      240

ctcattctgg acagcttcct gacccccagg aagaccatct ccttctcggg ctgtgccgtg      300

cagatgtttc tctccttcgc catgggagcc acagagtgtg tgctcctggg catgatggcg      360

tttgatcgtt atgtggccat ctgcaacccc cttagatatc ctgtggtcat gagcaaggct      420

gcctatgtgc ccatggccgc cggctcctgg gtatctggaa gcatcactgc cacagtgcag      480

atatctttag caatgacact gcccttctgt ggggacaatg tcatcaatca ctttacatgt      540

gagatcctgg cagtcctgaa actggcctgt gctgacatct ccatcaatgt catcagcatg      600

gcagtggcta atgcaatgtt tttgggggtc cctgtcctct tcatctttgt ctcctacatc      660

ttcatactct ccaccatcct gaggatcccc tctgccgagg ggaggaagaa ggcattctcc      720

acctgctctg cccacctcac cgtggtactt gtcttctatg ggaccatcct gttcatgtac      780

gggaagccca aatccaagga cccattgggg gcagacaaac aggaccttgc agacaagctc      840

atctccctct tctatggagt ggtgaccccc atgctgaacc ccatcatcta cagcctgagg      900

aacaaggatg tgaaggccgc tgtgacaaac ctggtgggcc agaaacactt caagtggtga      960


<210>  63
<211>  960
<212>  DNA
<213>  Mus musculus

<400>  63
atggtacagg gaaattggac ctctgtcaca gtgtttgttt ttctgggatt ttcgcactac       60

cccagaattg aagtcaccgt atttgtgctg tgtctgctga tgtatctgat caccttgctg      120

ggaaatacta ttctgatctc catcactatc cttgattctc atctgcacac tcccatgtac      180

tttttcctca gcaacctctc atttctggac atctggtata cctcttctgc tctcactcct      240

atgctggcaa actttgtttc agggaaaaac accatttcct tctcgggatg tgcctcgcag      300

atgtacttct ctcttgccat gggctccact gaatgtgtgc tcctctctat gatggcctat      360

gacaggtatg tggccatctg taacccactg agatatccca ttattatgaa caggagggtc      420

tgtgtacaga ttgcaggcag ctcctgggtt acaggctgcc tcactgcctt ggtggaaact      480

ggacctgtga ttcatctgtc tctctgtggt aacagcatca tcaatcattt cacctgtgaa      540

attctggctc tcttaaaatt ggcctgtgga gacacttcca tggtacagtt aattatgctg      600

gtgatcagca ttcttcttct cccattgcca atgttgctca tttgtgtctc ctatgcatct      660

atcctctcca acatcttgag gatcagctca atggatggcc gaagcaaagc cttttcaaca      720

tgtgcagccc acttgactgt ggtggttctg ttctatggga cagctctctc catgtacctg      780

aagccctcat ctgtaaactc acaggaaatt gataaattta tggcattaat atatactgga      840

ctaacaccaa tgctaaatcc tattatctac agtctacgga acaaagaagt aaaaatggct      900

gtgaaaaaat tgttgatgaa aaaccccttc agtgctatct taacttctgt cctcaaataa      960


<210>  64
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  64
atgaaaatca accagacaat cctgaaggaa ttcattcttg ttggcttttc tgtgtaccca       60

catgtacaga catttctttt tgtggtcttc ttttgtctct accttctcac ccttgcaggt      120

aatctgatca tcatgggtct aacttgggtg gacaggtccc tccacacccc tatgtatctc      180

ttccttagtg cactctcctt ctctgagacc tgctatacgc tgaccatcgt ccccaagatg      240

ctggaagatc tactggccaa ggacagaagc atttcagtca caggttgtag cttacagatg      300

tgcttcttct tgggacttgg tggcacaaac tgtatcattc tcactttgat gggatatgac      360

cgcttcctgg ccatctgtaa ccctctaaga tatccactgc ttatgaccaa cattgtatgt      420

ggacaacttg tggcctctgc ttgcactgca ggcttcttta tctctcttac agagactgca      480

ctgatattca gggactcttt ctgcagaccc aaccttgtca aacacttctt ctgccatatg      540

ctggcagtta ttaggctgtc ttgtatagac agtaaccaca cagaattcat tataacactg      600

atctcagtgt ctggtttgct gggtaccctt ctgctcatca tcctgactga tgtcttcatt      660

atttctactg tcctcaggat cccttcagct gagggcaagc agaaggcatt caccacctgt      720

gcctcccacc tcaccgtggt tataatccac tttggttttg catctattgt ttatttgaag      780

ccagaagcct caggagatga cacactcata gcagtccctt atactgtcat tacccccttc      840

ctcagcccca tcatattcag cctgaggaat aaggacatga aaaatgcttt tagaagaatg      900

atgggaaaca cagttgcctt gaaaaaataa                                       930


<210>  65
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  65
atggaaccgc tcaacagaac agaggtgtcc gagttctttc tgaaaggatt ttctggctac       60

ccagccctgg agcatctgct cttccctctg tgctcagcca tgtacctggt gaccctcctg      120

gggaacacag ccatcatggc ggtgagcgtg ctagatatcc acctgcacac gcccgtgtac      180

ttcttcctgg gcaacctctc taccctggac atctgctaca cgcccacctt tgtgcctctg      240

atgctggtcc acctcctgtc atcccggaag accatctcct ttgctgtctg tgccatccag      300

atgtgtctga gcctgtccac gggctccacg gagtgcctgc tactggccat cacggcctat      360

gaccgctacc tggccatctg ccagccactc aggtaccgcg tgctcatgag ccaccggctc      420

tgcgtgctgc tgatgggagc tgcctgggtc ctctgcctcc tcaagtcggt gactgagatg      480

gtcatctcca tgaggctgcc cttctgtggc caccacgtgg tcagtcactt cacctgcaag      540

atcctggcag tgctgaagct ggcatgcggc aacacgtcgg tcagcgaaga cttcctgctg      600

gcgggctcca tcctgctgct gcctgtaccc ctggcattca tctgcctgtc ctacttgctc      660

atcctggcca ccatcctgag ggtgccctcg gccgccaggt gctgcaaagc cttctccacc      720

tgcttggcac acctggctgt agtgctgctt ttctacggca ccatcatctt catgtacttg      780

aagcccaaga gtaaggaagc ccacatctct gatgaggtct tcacagtcct ctatgccatg      840

gtcacgacca tgctgaaccc caccatctac agcctgagga acaaggaggt gaaggaggcc      900

gccaggaagg tgtggggcag gagtcgggcc tccaggtga                             939


<210>  66
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  66
atggaaaaag ccaatgagac ctcccctgtg atggggttcg ttctcctgag gctctctgcc       60

cacccagagc tggaaaagac attcttcgtg ctcatcctgc tgatgtacct cgtgatcctg      120

ctgggcaatg gggtcctcat cctggtgacc atccttgact cccgcctgca cacgcccatg      180

tacttcttcc tagggaacct ctccttcctg gacatctgct tcactacctc ctcagtccca      240

ctggtcctgg acagcttttt gactccccag gaaaccatct ccttctcagc ctgtgctgtg      300

cagatggcac tctcctttgc catggcagga acagagtgct tgctcctgag catgatggca      360

tttgatcgct atgtggccat ctgcaacccc cttaggtact ccgtgatcat gagcaaggct      420

gcctacatgc ccatggctgc cagctcctgg gctattggtg gtgctgcttc cgtggtacac      480

acatccttgg caattcagct gcccttctgt ggagacaatg tcatcaacca cttcacctgt      540

gagattctgg ctgttctaaa gttggcctgt gctgacattt ccatcaatgt gatcagcatg      600

gaggtgacga atgtgatctt cctaggagtc ccggttctgt tcatctcttt ctcctatgtc      660

ttcatcatca ccaccatcct gaggatcccc tcagctgagg ggaggaaaaa ggtcttctcc      720

acctgctctg cccacctcac cgtggtgatc gtcttctacg ggaccttatt cttcatgtat      780

gggaagccta agtctaagga ctccatggga gcagacaaag aggatctttc agacaaactc      840

atcccccttt tctatggggt ggtgaccccg atgctcaacc ccatcatcta tagcctgagg      900

aacaaggatg tgaaggctgc tgtgaggaga ctgctgagac caaaaggctt cactcagtga      960


<210>  67
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  67
atgggagaga ttaaccagac acttgtgtca gaatttcttc ttctgggtct ttctggatac       60

ccaaagattg agattgttta ctttgctctc attctagtta tgtacctagt gattctaatt      120

ggcaatggtg ttctaatcat agccagcatc tttgattctc attttcacac accaatgtac      180

ttcttcctgg gcaacctctc tttcctggat atctgctata catcctcctc tgttccctca      240

acattggtga gcttaatctc aaagaaaaga aacatttcct tctctggatg tgcagtgcag      300

atgttctttg ggtttgcaat ggggtcaaca gaatgtctgc ttcttggcat gatggcattt      360

gatcgttatg tggccatctg caacccactg agatacccca tcatcctgag caaggtggcg      420

tatgtattga tggcttctgt gtcctggctg tccggtggaa taaattcagc tgtgcaaaca      480

ttacttgcca tgagactgcc tttctgtggg aataatatta tcaatcattt cgcatgtgaa      540

atattagctg tcctcaagct ggcctgtgct gatatatccc tcaatattat caccatggtg      600

atatcaaata tggccttcct ggttcttcca ctgatggtca tttttttctc ctatatgttc      660

atcctctaca ccatcttgca aatgaattca gccacaggaa gacgcaaggc attttccacg      720

tgctcagctc acctgactgt ggtgatcata ttttacggta ccatcttctt tatgtatgcg      780

aaaccgaagt ctcaagacct gattggggaa gaaaaattgc aagcattaga caagctcatt      840

tctctgtttt atggggtagt gacacccatg ctgaatccta tactctatag cttgagaaat      900

aaggatgtaa aagctgctgt aaaatatttg ctgaacaaaa aaccaattca ctaa            954


<210>  68
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  68
atggacaaga taaaccagac atttgtgaga gaattcattc ttctgggact ctctggttac       60

cccaaacttg agatcatttt ctttgctctg attctagtta tgtacgtagt gattctaatt      120

ggcaatggtg ttctgatcat agcaagcatc ttggattctc gtcttcacat gcccatgtac      180

ttcttcctgg gcaacctctc tttcctggat atctgctata caacctcctc cattccctca      240

acactggtga gcttaatctc aaagaaaaga aacatttcct tctctggatg tgcagtgcag      300

atgttctttg ggtttgcaat ggggtcaaca gaatgtttcc tccttggcat gatggcattt      360

gatcgttatg tggccatctg taaccctctg agatacccca tcatcatgaa caaggtggtg      420

tatgtactgc tgacttctgt atcatggctt tctggtggaa tcaattcaac tgtgcaaaca      480

tcacttgcca tgcgatggcc tttctgtggg aacaatatta ttaatcattt cttatgcgag      540

atcttagctg tcctaaaatt agcttgttct gatatatctg tcaatattgt taccctagca      600

gtgtcaaata ttgctttcct agttcttcct ctgctcgtga tttttttctc ctatatgttc      660

atcctctaca ccatcttgcg aacgaactcg gccacaggaa gacacaaggc attttctaca      720

tgctcagctc acctgactgt ggtgatcata ttttatggta ccatcttctt tatgtatgca      780

aaacctaagt cccaggacct ccttgggaaa gacaacttgc aagctacaga ggggcttgtt      840

tccatgtttt atggggttgt gacccccatg ttaaacccca taatctatag cttgagaaat      900

aaagatgtaa aagctgctat aaaatatttg ctgagcagga aagctattaa ccagtaa         957


<210>  69
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  69
atggaaagga ccaacgattc cacgtcgaca gaatttttcc tggtagggct ttctgaccac       60

ccaaagctcc agacagtttt cttcgttcta attttgtgga tgtacctgat gatcctgctt      120

ggaaatggag tccttatctc agttatcatc tttgattctc acctgcacac ccccatgtat      180

ttcttcctct gtaatctttc cttcctcgac gtttgctaca caagttcctc tgtcccacta      240

attcttgcca gctttctggc agtaaagaaa aaggtttcct tctctgggtg tatggtgcaa      300

atgtttattt cttttgccat gggggccacg gagtgcatga tcttaggcac gatggcactg      360

gaccgctatg tggccatctg ctacccactg agataccctg tcatcatgag caagggtgcc      420

tatgtggcca tggcagctgg gtcctgggtc actgggcttg tggactcagt agtgcagaca      480

gcttttgcaa tgcagttacc attctgtgct aataatgtca ttaaacattt tgtctgtgaa      540

attctggcta tcttgaaact ggcctgtgct gatatttcaa tcaatgtgat tagtatgaca      600

gggtcgaatc tgattgttct ggttattcca ttgttagtaa tttccatctc ttacatattt      660

attgttgcca ctattctgag gattccttcc actgaaggaa aacataagga cttctccacc      720

tgctcagccc acctgacagt ggtgattata ttctatggaa ccatcttctt catgtacgca      780

aagcctgagt ctaaagcctc tgttgattca ggtaatgaag acatcattga ggccctcatc      840

tcccttttct atggagtgat gactcccatg cttaatcctc tcatctatag tctgcgaaac      900

aaggatgtaa aggctgctgt caaaaacata ctgtgtagga aaaacttttc tgatggaaaa      960

tga                                                                    963


<210>  70
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  70
atggaatggg aaaaccacac cattctggtg gaattttttc tgaagggact ttctggtcac       60

ccaagacttg agttactctt ttttgtgctc atcttcataa tgtatgtggt catccttctg      120

gggaatggta ctctcatttt aatcagcatc ttggaccctc accttcacac ccctatgtac      180

ttctttctgg ggaacctctc cttcttggac atctgctaca ccaccacctc tattccctcc      240

acgctagtga gcttcctttc agaaagaaag accatttccc tttctggctg tgcagtgcag      300

atgttcctca gcttggccat ggggacaaca gagtgtgtgc ttctgggcgt gatggccttt      360

gaccgctatg tggctatctg caaccctctg agatatccca tcatcatgag taaggatgcc      420

tatgtaccca tggcagctgg gtcctggatc ataggagctg tcaattctgc agtacaaaca      480

gtgtttgtgg tacaattgcc tttctgcagg aataacatca tcaatcattt cacctgtgaa      540

attctagctg tcatgaaact ggcctgtgct gacatctcag gcaatgagtt catcctgctt      600

gtgaccacaa cattgttcct attgacacct ttgttattaa ttattgtctc ttacacgtta      660

atcattttga gcatcttcaa aattagctct tcggagggga gaagcaaacc ttcctctacc      720

tgctcagctc gtctgactgt ggtgataaca ttctgtggga ccatcttcct catgtacatg      780

aagcccaagt ctcaagagac acttaattca gatgacttgg atgccactga caaacttata      840

ttcatattct acagggtgat gactcccatg atgaatcctt taatctacag tcttagaaac      900

aaggatgtga aggaggcagt aaaacaccta ctgagaagaa aaaattttaa caagtaa         957


<210>  71
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  71
atggaatggg aaaaccacac cattctggtg gaattttttc tgaagggact ttctggtcac       60

ccaagacttg agttactctt ttttgtgctc atcttcataa tgtatgtggt catccttctg      120

gggaatggta ctctcatttt aatcagcatc ttggaccctc accttcacac ccctatgtac      180

ttctttctgg ggaacctctc cttcttggac atctgctaca ccaccacctc tattccctcc      240

acgctagtga gcttcctttc agaaagaaag accatttccc tttctggctg tgcagtgcag      300

atgttcctcg gcttggccat ggggacaaca gagtgtgtgc ttctgggcat gatggccttt      360

gaccgctatg tggctatctg caaccctctg agatatccca tcatcatgag taaggatgcc      420

tatgtaccca tggcagctgg gtcctggatc ataggagctg tcaattctgc agtacaatca      480

gtgtttgtgg tacaattgcc tttctgcagg aataacatca tcaatcattt cacctgtgaa      540

attctggctg tcatgaaact ggcctgtgct gacatctcag acaatgagtt catcatgctt      600

gtggccacaa cattgttcat attgacacct ttgttattaa tcattgtctc ttacacgtta      660

atcattgtga gcatcttcaa aattagctct tccgagggga gaagcaaagc ttcctctacc      720

tgttcagccc atctgactgt ggtcataata ttctatggga ccatcctctt catgtacatg      780

aagcccaagt ctaaagagac acttaattcg gatgacttgg atgctaccga caaaattata      840

tccatgttct atggggtgat gactcccatg atgaatcctt taatctacag tcttagaaac      900

aaggatgtga aagaggcagt aaaacaccta ctgaacagaa ggttctttag caagtga         957


<210>  72
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  72
atggaatggg aaaaccaaac cattctggtg gaattttttc tgaagggaca ttctgttcac       60

ccaaggcttg agttactctt ttttgtgcta atcttcataa tgtatgtggt catccttctg      120

gggaatggta ctctcatttt aatcagcatc ttggaccctc accttcacac ccctatgtac      180

ttctttctgg ggaacctctc cttcttggac atctgctaca ccaccacctc tattccctcc      240

acactagtga gcttcctttc agaaagaaag accatttcct tttctggctg tgcagtgcag      300

atgttccttg gcttggccat ggggacaaca gagtgtgtgc ttctgggcat gatggccttt      360

gaccgctatg tggctatctg caaccctctg agatatccca tcatcatgag caagaatgcc      420

tatgtaccca tggctgttgg gtcctggttt gcagggattg tcaactctgc agtacaaact      480

acatttgtag tacaattgcc tttctgcagg aagaatgtca tcaatcattt ctcatgtgaa      540

attctagctg tcatgaagtt ggcctgtgct gacatctcag gcaatgagtt cctcatgctt      600

gtggccacaa tattgttcac attgatgcca ctgctcttga tagttatctc ttactcatta      660

atcatttcca gcatcctcaa gattcactcc tctgagggga gaagcaaagc tttctctacc      720

tgctcagccc atctgactgt ggtcataata ttctatggga ccatcctctt catgtatatg      780

aagcccaagt ctaaagagac acttaattca gatgacttgg atgctaccga caaaattata      840

tccatgttct atggggtgat gactcccatg atgaatcctt taatctacag tcttagaaac      900

aaggatgtga aagaggcagt aaaacaccta ccgaacagaa ggttctttag caagtga         957


<210>  73
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  73
atggaaacaa gaaattactc tgccatgact gaattctttc tggtggggct ttcccaatat       60

ccagagctcc agctttttct gttcctgctc tgcctcatca tgtacatgat aatcctcctg      120

ggaaatagcc tcctcattat catcaccatc ttggattctc gcctccatac tcccatgtat      180

ttctttcttg gaaacctctc attcttggac atctgttaca catcctcatc cattcctcca      240

atgcttatta tatttatgtc tgagagaaaa tccatctcct tcattggctg tgctctgcag      300

atggttgtgt cccttggctt gggctccact gagtgtgtcc tcctggctgt gatggcctat      360

gaccactatg tggccatctg caacccactg aggtactcca tcatcatgaa cggagtgctg      420

tatgtgcaaa tggctgcatg gtcctggatc ataggctgtc tgacctccct attgcacaca      480

gttctgacaa tgatgttgcc tttctgtggg aataatgtca ttgatcatat tacctgtgaa      540

attttggccc ttctaaaact tgtttgttca gatatcacca tcaatgtgct tatcatgaca      600

gtgacaaata ttgtttcact ggtgattctt ctactgttaa ttttcatctc ctatgtgttt      660

attctctctt ccatcctgag aattaattgt gctgagggaa gaaagaaagc cttctctacc      720

tgttcagcgc acttgattgt ggtcatctta ttctacggtt cagccctttt tatgtacatg      780

aaacccaagt caaagaacac taatacatct gatgagatta ttgggctgtc ttatggagtg      840

gtaagcccaa tgttaaatcc catcatctat agcctcagga ataaagaggt caaagaggct      900

gtaaagaaag tcctgagcag acatctgcat ttattgaaaa tgtga                      945


<210>  74
<211>  951
<212>  DNA
<213>  Homo sapiens

<400>  74
atgcaaggag aaaacttcac catttggagc atttttttct tggagggatt ttcccagtac       60

ccagggttag aagtggttct cttcgtcttc agccttgtaa tgtatctgac aacgctcttg      120

ggcaacagca ctcttatttt gatcactatc ctagattcac gccttaaaac ccccatgtac      180

ttattccttg gaaatctctc tttcatggat atttgttaca catctgcctc tgttcctact      240

ttgctggtga acttgctgtc atcccagaaa accattatct tttctgggtg tgctgtacag      300

atgtatctgt cccttgccat gggctccaca gagtgtgtgc tcctggccgt gatggcatat      360

gaccgttatg tggccatttg taacccgctg agatactcca tcatcatgaa caggtgcgtc      420

tgtgcacgga tggctacggt ctcctgggtg acgggttgcc tgaccgctct gctggaaacc      480

agttttgccc tgcagatacc cctctgtggg aatctcatcg atcacttcac gtgtgaaatt      540

ctggcggtgc taaagttagc ttgcacaagt tcactgctca tgaacaccat catgctggtg      600

gtcagcattc tcctcttgcc aattccaatg ctcttagttt gcatctctta catcttcatc      660

ctttccacta ttctgagaat cacctcagca gagggaagaa acaaggcttt ttctacctgt      720

ggtgcccatt tgactgtggt gattttgtat tatggggctg ccctctctat gtacctaaag      780

ccttcttcat caaatgcaca aaaaatagac aaaatcatct cgttgcttta cggagtgctt      840

acccctatgt tgaaccccat aatttacagt ttaagaaaca aggaagtcaa agatgctatg      900

aagaaattgc tgggcaaaat aacattgcat caaacacacg aacatctctg a               951


<210>  75
<211>  944
<212>  DNA
<213>  Homo sapiens

<400>  75
atgttaatga attactctag tgccactgaa ttttatctcc ttggcttccc tggctctgaa       60

gaactacatc atatcctttt tgctatattc ttctttttct acttggtgac attaatggga      120

aacacagtca tcatcatgat tgtctgtgtg gataaacgtc tgcagtcccc catgtatttc      180

ttcctcggcc acctctctgc cctggagatc ctggtcacaa ccataatcgt ccccgtgatg      240

ctttggggat tgctgctccc tgggatgcag acaatatatt tgtctgcctg tgttgtccag      300

ctcttcttgt accttgctgt ggggacaaca gagttcgcat tacttggagc aatggctgtg      360

gaccgttatg tggctgtctg taaccctctg aggtacaaca tcattatgaa cagacacacc      420

tgcaactttg tggttcttgt gtcatgggtg tttgggtttc tttttcaaat ctggccggtc      480

tatgtcatgt ttcagcttac ttactgcaaa tcaaatgtgg tgaacaattt tttttgtgac      540

cgagggcaat tgctcaaact atcctgcaat aatactcttt tcacggagtt tatcctcttc      600

ttaatggctg tttttgttct ctttggttct ttgatcccta caattgtctc caacgcctac      660

atcatctcca ccattctcaa gatcccgtca tcctctggcc ggaggaaatc cttctccact      720

tgtgcctccc acttcacctg tgttgtgatt ggctacggca gctgcttgtt tctctacgtg      780

aaacccaagc aaacgcaggc agctgattac aattgggtag tttccctgat ggtttcagta      840

gtaactcctt tcctcaatcc tttcatcttc accctccgga atgataaagt catagaggcc      900

cttcgggatg gggtgaaacg ctgctgtcaa ctattcagga atta                       944


<210>  76
<211>  933
<212>  DNA
<213>  Homo sapiens

<400>  76
atgatggaca accactctag tgccactgaa ttccaccttc taggcttccc tgggtcccaa       60

ggactacacc acattctttt tgctatattc tttttcttct atttagtgac attaatggga      120

aacacggtca tcattgtgat tgtctgtgtg gataaacgtc tgcagtcccc catgtatttc      180

ttcctcagcc acctctctac cctggagatc ctggtcacaa ccataattgt ccccatgatg      240

ctttggggat tgctcttcct gggatgcaga cagtatcttt ctctacatgt atcgctcaac      300

ttttcctgtg ggaccatgga gtttgcatta cttggagtga tggctgtgga ccgttatgtg      360

gctgtgtgta accctttgag gtacaacatc attatgaaca gcagtacctg tatttgggtg      420

gtaatagtgt catgggtgtt tggatttctt tctgaaatct ggcccatcta tgccacattt      480

cagtttacct tccgcaaatc aaattcatta gaccattttt actgtgaccg agggcaattg      540

ctcaaactgt cctgcgataa cactcttctc acagagttta tccttttctt aatggctgtt      600

tttattctca ttggttcttt gatccctacg attgtctcct acacctacat tatctccacc      660

atcctcaaga tcccgtcagc ctctggccgg aggaaagcct tctccacttt tgcctcccac      720

ttcacctgtg ttgtgattgg ctatggcagc tgcttgtttc tctacgtgaa acccaagcaa      780

acacagggag ttgagtacaa taagatagtt tccctgttgg tttctgtgtt aacccccttc      840

ctgaatcctt tcatctttac tcttcggaat gacaaagtca aagaggccct ccgagatggg      900

atgaaacgct gctgtcaact cctgaaagat tag                                   933


<210>  77
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  77
atgagaaatg gcacagtaat cacagaattc atcctgctag gctttcctgt tatccaagga       60

ctacaaacac ctctctttat tgcaatcttt ctcacctaca tattaaccct tgcaggcaat      120

gggcttatta ttgccactgt gtgggctgag cccaggctac aaattccaat gtacttcttc      180

ctttgtaact tgtctttctt agaaatctgg tacaccacca cagtcatccc caaactgcta      240

ggaacctttg tagtggcaag aacagtaatc tgcatgtcct gctgcctgct gcaggcattc      300

ttccacttct tcgtgggcac caccgagttc ttgatcctca ctatcatgtc ttttgaccgc      360

tacctcacca tctgcaatcc ccttcaccac cccaccatca tgaccagcaa actctgcctg      420

cagctggccc tgagctcctg ggtggtgggc ttcaccattg tcttttgtca gacgatgctg      480

ctcatccagt tgccattctg tggcaataat gttatcagtc atttctactg tgatgttggg      540

cccagtttga aagccgcctg catagacacc agcattttgg aactcctggg cgtcatagca      600

accatccttg tgatcccagg gtcacttctc tttaatatga tttcttatat ctacattctg      660

tccgcaatcc tacgaattcc ttcagccact ggccaccaaa agactttctc tacctgtgcc      720

tcgcacctga cagttgtctc cctgctctac ggggctgttc tgttcatgta cctaagaccc      780

acagcacact cctcctttaa gattaataag gtggtgtctg tgctaaatac tatcctcacc      840

ccccttctga atccctttat ttatactatt agaaacaagg aggtgaaggg agccttaaga      900

aaggcaatga cttgcccaaa gactggtcat gcaaagtaa                             939


<210>  78
<211>  942
<212>  DNA
<213>  Homo sapiens

<400>  78
atgggagaca ggggaacaag caatcactca gaaatgactg acttcattct tgcaggcttc       60

agggtacgcc cagagctcca cattctcctc ttcctgctat ttttgtttgt ttatgccatg      120

atccttctag ggaatgttgg gatgatgacc attattatga ctgatcctcg gctgaacaca      180

ccaatgtatt ttttcctagg caatctctcc ttcattgatc ttttctattc atctgttatt      240

gaacccaagg ctatgatcaa cttctggtct gaaaacaagt ctatctcctt tgcaggctgt      300

gtggcccagc tctttctctt tgccctcctc attgtgactg agggatttct cctggcggcc      360

atggcttatg accgctttat tgccatctgc aaccctctgc tctactctgt tcaaatgtcc      420

acacgtctgt gtactcagtt ggtggctggt tcctattttt gtggctgcat tagctcagtt      480

attcagacta gcatgacatt tactttatct ttttgcgctt ctcgggctgt tgaccacttt      540

tactgtgatt ctcgcccact tcagagactg tcttgttctg atctctttat ccatagaatg      600

atatcttttt ccttatcatg tattattatc ttgcctacta tcatagtcat tatagtatct      660

tacatgtata ttgtgtccac agttctaaag atacattcta ctgagggaca taagaaagcc      720

ttctccacct gcagctctca cctgggagtt gtgagtgtgc tgtatggtgc tgtctttttt      780

atgtatctca ctcctgacag atttcctgag ctgagtaaag tggcatcctt atgttactcc      840

ctagtcactc ccatgttgaa tcctttgatt tactctctga ggaacaaaga tgtccaagag      900

gctctaaaaa aatttctaga gaagaaaaat attattcttt ga                         942


<210>  79
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  79
atgttcccgg caaattggac atctgtaaaa gtatttttct tcctgggatt ttctcactac       60

cccaaagttc aggtcatcat atttgcggtg tgcttgctga tgtacctgat caccttgctg      120

ggcaacattt ttctgatctc catcaccatt ctagattccc acctgcacac ccctatgtac      180

ctcttcctca gcaatctctc ctttctggac atctggtact cctcttctgc cctctctcca      240

atgctggcaa actttgtttc agggagaaac actatttcat tctcagggtg cgccactcag      300

gtgtacctct cccttgccat gggctccact gagtgtgtgc tcctgcccat gatggcatat      360

gaccggtatg tggccatctg caaccccctg agatacccta tcatcatgaa taggagaacc      420

tgtgtgcaga ttgcagctgg ctcctggatg acaggctgtc tcactgccat ggtggaaatg      480

atgtctgtgc tgccactgtc tctctgtggt aatagcatca tcaatcattt cacttgtgaa      540

attctggcca tcttgaaatt ggtttgtgtg gacacctccc tggtgcagtt aatcatgctg      600

gtgatcagtg tacttcttct ccccatgcca atgctactca tttgtatctc ttatgcattt      660

atcctcgcca gtatcctgag aatcagctca gtggaaggtc gaagtaaagc cttttcaacg      720

tgcacagccc acctgatggt ggtagttttg ttctatggga tggctctctc catgcacctg      780

aagccctccg ctgtagattc acaggaaata gacaaattta tggctttggt gtatgccgga      840

caaaccccca tgttgaatcc tatcatctat agtctacgga acaaagaggt gaaagtggcc      900

ttgaaaaaat tgctgattag aaatcatttt aatactgcct tcatttccat cctcaaataa      960


<210>  80
<211>  960
<212>  DNA
<213>  Rattus norvegicus

<400>  80
atggtacagg gaaattggtc ctctgtcaca gtgtttttct tcctgggatt ttctcagtac       60

cccagaattg aagtcaccat atttgtgctg tgtctgctga tgtacctgat caccttgctg      120

ggaaatacta ttctgatctc catcactatc cttgattctc acctgcacac tcccatgtac      180

tttttcctta gcaacctctc ctttctggac atctggtata cctcttctgc tctcactcct      240

atgctggcaa actttgtttc aggggaaaac accatctcat tctcaggatg tgcttttcag      300

atgtacttct ctcttgccat gggctccacg gaatgtgtgc tcctctctat gatggcctat      360

gacaggtacg tggccatctg caaccccctg agatatccca tcattatgaa caggagagtc      420

tgtgtacaga ttgcaggcag ctcctgggtt acaggctgcc tcactgcctt ggtggaaact      480

ggacctgtga ttcatctgtc tctctgtggt aataacatca tcaatcattt cacctgtgaa      540

attctggctc tcttaaaaat ggcttgtgga gacactgcca tggtgcagtt aattatgtta      600

gtgatcagca tccttcttct cccattgcca atgttgctca tttgtgtctc ctatgcatcc      660

atcctctcca acatcttgag gatcagctca gtggatggcc gaagcaaagc cttttcaaca      720

tgtgcagccc acttgactgt ggtggttctg ttctatgaga cagctctctc catgtacctg      780

aagcccttat ctgtaaactc acaggaaata gataaattta tggcattgat atatgttgga      840

ctaacaccaa tgctaaatcc tattatctac agtctacgga acaaagaagt caaaatggct      900

gtgaaaaaat tgttgattaa aaatcccttc actgctatct taacttctgt cctcaaataa      960


<210>  81
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ENHANCER SEQUENCE

<400>  81
aactttttaa tga                                                          13


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ENHANCER SEQUENCE

<400>  82
acataacttt ttaatgagtc t                                                 21


<210>  83
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ENHANCER SEQUENCE, WHERE Y=C/T AND R=A/G

<400>  83
yttttaatga r                                                            11


