                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       SCHREIBER, Gideon
       ZAHRADNIK, Jiri
       RUDICH, Yinon
 
<120>  METHODS AND COMPOSITIONS FOR TREATING CORONAVIRAL INFECTIONS

<130>  89026

<150>  US  63/125,984
<151>  2020-12-16

<150>  IL 277546
<151>  2020-09-23

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
ggcggtagcg gaggcggagg gtcggctagc cattgccctt ttggtgaagt ttttaacg         58


<210>  2
<211>  76
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ctattacaag tcctcttcag aaataagctt ttgttcggat ccttcaaaag aaagtactac       60

tactctgtat ggttgg                                                       76


<210>  3
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ggcggtagcg gaggcggagg gtcggctagc catccaaaca tcaccaacct gtgtc            55


<210>  4
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
ctattacaag tcctcttcag aaataagctt ttgttcggat ccctttggtc cacacactgt       60

ggc                                                                     63


<210>  5
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
ggcggtagcg gaggcggagg gtcggctagc catagggtcc aaccaacaga gag              53


<210>  6
<211>  67
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
ctattacaag tcctcttcag aaataagctt ttgttcggat ccgaagttca cacacttgtt       60

cttcacc                                                                 67


<210>  7
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
ctgctttggc tgctccagct aatggtcata tgtgcccttt tggtgaagtt tttaacg          57


<210>  8
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
gcccgaacca cctccaccag aggatccttc aaaagaaagt actactactc tgtatggttg       60

g                                                                       61


<210>  9
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
tgcccttttg gtgaagtttt taacgccacc aggtttgcct ctgtc                       45


<210>  10
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
ttcaaaagaa agtactacta ctctgtatgg ttggtagccc actccattgg ttgg             54


<210>  11
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
ctacaaactg cctgatgact tcac                                              24


<210>  12
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
gtccaggttg ttgctgttcc ag                                                22


<210>  13
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  13
ccatgttcgt gtttctggtg ctgctgcctc tggtgtccag caccaacctg tgcccttttg       60

gtgaagtttt taacg                                                        75


<210>  14
<211>  87
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  14
ccatgttcgt gtttctggtg ctgctgcctc tggtgtccag caccccaaac atcaccaacc       60

tgtgcccttt tggtgaagtt tttaacg                                           87


<210>  15
<211>  79
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  15
cgacttaaga tcgatgcggc cgcgagctcg aattttatca atggtgatgg tgatggtgct       60

ttggtccaca cactgtggc                                                    79


<210>  16
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  16
cgccaccagg tttgcctctg tctatgcctg ggaaaggaag aggtttagca actgtgtg         58


<210>  17
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  17
caggaagagg tttagcaact gtgtggctga ctggtctgtg ctctacaact ctgcc            55


<210>  18
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
gaagaggttt agcaactgtg tggctgacta ctcttggctc tacaactctg cctccttcag       60


<210>  19
<211>  65
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
cttcagcacc ttcaagtgtt atggagtgag cccacgtaaa ctgaatgacc tgtgtttcac       60

caatg                                                                   65


<210>  20
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
ctgactcctt tgtgattagg ggagatgagg tggatcagat tgcccctgga caaacag          57


<210>  21
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
gggagatgag gtgagacaga ttgcccctgg agccacaggc aagattgctg actacaac         58


<210>  22
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
ggtgagacag attgcccctg gacaaacagg cgttattgct gactacaact acaaactgcc       60


<210>  23
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
gacagcaagg tgggaggcaa ctacaactac ctctttagac tgttcaggaa gagcaagc         58


<210>  24
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
ggtgggaggc aactacaact acctctacag acgtttcagg aagagcaagc tgaaacc          57


<210>  25
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
gagtgaaggg cttcaactgt tacttcccac tcatgtccta tggcttccga ccaacc           56


<210>  26
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
ccaggctggc agcacaccat gtaatggagt gcgcggcttc aactgttact tcccactc         58


<210>  27
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
ctgttacttc ccactccaat cctatggctt ccatccaacc tatggagtgg gctacc           56


<210>  28
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
cttcccactc caatcctatg gcttccgacc aacctttgga gtgggctacc aaccatac         58


<210>  29
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
cctatggctt ccgaccaacc tatggagtgg gctggcaacc atacagggtg gtggtgc          57


<210>  30
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
ccaaccatac agggtggtgg tgctgtcctt tgaaatgctc catgcccctg ccacagtg         58


<210>  31
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
gtgaagggct tcaactgtta ctttccactc caaccttatg gcttccgacc aacctatg         58


<210>  32
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
gcaagaaggg aggcaactac aactacctct acagacgttt caggaagagc aaactgaaac       60

catttg                                                                  66


<210>  33
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein sequence of modified eUnaG2

<400>  33

Met Leu Glu Lys Phe Val Gly Thr Trp Lys Ile Glu Ser Ser Glu Asn 
1               5                   10                  15      


Phe Gly Glu Tyr Leu Lys Ala Ile Gly Ala Pro Lys Glu Leu Ala Asp 
            20                  25                  30          


Ala Gly Asp Ala Thr Thr Pro Val Leu Tyr Ile Ser Gln Lys Asp Gly 
        35                  40                  45              


Asp Lys Met Thr Val Lys Ile Glu Asn Gly Pro Pro Thr Phe Leu Asp 
    50                  55                  60                  


Thr Gln Val Ser Phe Lys Leu Gly Glu Glu Phe Asp Glu Phe Pro Ser 
65                  70                  75                  80  


Asp Arg Arg Lys Gly Val Lys Ser Val Val Asn Leu Ser Gly Glu Lys 
                85                  90                  95      


Leu Val Tyr Val Gln Lys Trp Asp Gly Lys Glu Thr Thr Tyr Val Arg 
            100                 105                 110         


Glu Ile Lys Asp Gly Lys Leu Val Val Thr Leu Thr Met Gly Asp Val 
        115                 120                 125             


Val Ala Val Arg Ser Tyr Arg Arg Ala Ser Glu 
    130                 135                 


<210>  34
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of modified eUnaG2

<400>  34
atgttagaaa aatttgttgg cacctggaag atcgaatcct ctgaaaattt tggtgaatac       60

ttgaaggcta tcggtgcccc aaaagaattg gctgatgctg gtgatgctac tactccagtc      120

ttgtacattt ctcaaaagga tggtgataag atgaccgtca agattgaaaa cggtccacca      180

acttttttgg atacccaagt ttctttcaag ttgggtgaag aattcgacga atttccatcc      240

gatagaagaa agggtgttaa gtccgttgtt aacttgtctg gtgagaagtt ggtttacgtt      300

caaaagtggg atggtaaaga aaccacttac gtcagagaaa tcaaggacgg taaattggtt      360

gttactttga ccatgggtga tgttgttgct gttagatctt atagaagggc ctctgaataa      420


<210>  35
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DnbALFA  amino acid sequence

<400>  35

Met Ser Gly Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Asn Gly Ser Leu Arg Leu Ser Cys Asn Ala Ser Gly Val Thr Ile 
            20                  25                  30          


Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
        35                  40                  45              


Glu Arg Arg Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met 
    50                  55                  60                  


Tyr Arg Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Asn Asn Met Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg Gly Asp Thr Phe His 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DnbALFA nucleic acid sequence

<400>  36
atgagcggtg aagttcagct gcaagaaagc ggtggtggtc tggttcagcc taatggtagc       60

ctgcgtctga gctgtaacgc aagcggtgtt accattagcg cactgaatgc aatggcaatg      120

ggttggtatc gtcaggcacc gggtgaacgt cgtgttatgg ttgcagcagt tagcgaacgt      180

ggtaatgcaa tgtatcgtga aagcgttaaa ggtcgtttta ccatttctcg tgataatgct      240

aacaatatgg ttagcctgca gatggataat ctgaaaccgg aagataccgc agtgtattat      300

tgtcatgttc tggaagatcg tggtgatact tttcatgatt attggggtca gggcacccag      360

gttaccgtta gcagc                                                       375


<210>  37
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  37

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  38
<211>  196
<212>  PRT
<213>  Artificial sequence

<220>
<223>  B52 amino acid sequence

<400>  38

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      


Ser Val Tyr Ala Trp Asn Arg Lys Arg Phe Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Lys 
        115                 120                 125             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 


Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 


Gln Pro Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Gly Pro Ala Thr Val 
            180                 185                 190         


Cys Gly Pro Lys 
        195     


<210>  39
<211>  196
<212>  PRT
<213>  Artificial sequence

<220>
<223>  B62 amino acid sequence

<400>  39

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      


Ser Val Tyr Ala Trp Asn Arg Lys Arg Phe Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         


Lys Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Lys 
        115                 120                 125             


Leu Lys Pro Phe Glu Arg Asp Thr Ser Met Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 


Asn Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 


Gln Ser Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            180                 185                 190         


Cys Gly Pro Lys 
        195     


<210>  40
<211>  196
<212>  PRT
<213>  Artificial sequence

<220>
<223>  B71 amino acid sequence

<400>  40

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      


Ser Val Tyr Ala Trp Asn Arg Lys Arg Phe Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Trp Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Asp Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         


Lys Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Lys 
        115                 120                 125             


Leu Lys Pro Phe Glu Arg Asp Thr Ser Met Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 


Asn Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 


Gln Ser Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            180                 185                 190         


Cys Gly Pro Lys 
        195     


<210>  41
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker sequence GPGcP amino acid sequence

<400>  41

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


Ala Ser 
65      


<210>  42
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker NGL amino acid sequence

<400>  42

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asn Gly Ser Asn Gly Ser 
1               5                   10                  15      


Gly Gly Ser Asn Gly Ser Asn Gly Ser Gly Gly Ser Asn Gly Ser Asn 
            20                  25                  30          


Gly Ser Gly Gly Ser Asn Gly Ser Asn Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Gly 
    50                  55  


<210>  43
<211>  455
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Dimer amino acid sequence

<400>  43

Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      


Ser Val Tyr Ala Trp Asn Arg Lys Arg Phe Ser Asn Cys Val Ala Asp 
            20                  25                  30          


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         


Lys Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Lys 
        115                 120                 125             


Leu Lys Pro Phe Glu Arg Asp Thr Ser Met Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 


Asn Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 


Gln Ser Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            180                 185                 190         


Cys Gly Pro Lys Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        195                 200                 205             


Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
    210                 215                 220                 


Pro Ser Pro Ser Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
                245                 250                 255     


Pro Ser Pro Ser Ala Ser Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
            260                 265                 270         


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Phe Ser Asn Cys 
        275                 280                 285             


Val Ala Asp Tyr Ser Trp Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
    290                 295                 300                 


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
305                 310                 315                 320 


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Asp Gln 
                325                 330                 335     


Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu 
            340                 345                 350         


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
        355                 360                 365             


Asp Ser Lys Lys Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
    370                 375                 380                 


Lys Ser Lys Leu Lys Pro Phe Glu Arg Asp Thr Ser Met Glu Ile Tyr 
385                 390                 395                 400 


Gln Ala Gly Asn Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr 
                405                 410                 415     


Phe Pro Leu Gln Ser Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly Tyr 
            420                 425                 430         


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
        435                 440                 445             


Ala Thr Val Cys Gly Pro Lys 
    450                 455 


<210>  44
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ace2 amino acid sequence

<400>  44

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln 
    50                  55                  60  


<210>  45
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Arg319-Phe541 of SEQ ID NO: 37

<400>  45

Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
1               5                   10                  15      


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val 
        35                  40  


<210>  46
<211>  588
<212>  DNA
<213>  Artificial sequence

<220>
<223>  B52 nucleotide sequence

<400>  46
accaacctgt gcccttttgg tgaagttttt aacgccacca ggtttgcctc tgtctatgcc       60

tggaacagga agaggtttag caactgtgtg gctgactact ctgtgctcta caactctgcc      120

tccttcagca ccttcaagtg ttatggagtg agcccaacca aactgaatga cctgtgtttc      180

accaatgtct atgctgactc ctttgtgatt aggggagatg aggtgagaca gattgcccct      240

ggacaaacag gcaagattgc tgactacaac tacaaactgc ctgatgactt cacaggctgt      300

gtgattgcct ggaacagcaa caacctggac agcaaggtgg gaggcaacta caactacctc      360

tacagactgt tcaggaagag caaactgaaa ccatttgaga gggacatcag cacagagatt      420

taccaggctg gcagcacacc atgtaatgga gtgaagggct tcaactgtta ctttccactc      480

caaccctatg gcttccgacc aacctatgga gtgggctacc aaccatacag ggtggtggtg      540

ctgtcctttg aactgctcca tggccctgcc acagtgtgtg gaccaaag                   588


<210>  47
<211>  588
<212>  DNA
<213>  Artificial sequence

<220>
<223>  B62 nucleotide sequence

<400>  47
accaacctgt gcccttttgg tgaagttttt aacgccacca ggtttgcctc tgtctatgcc       60

tggaacagga agaggtttag caactgtgtg gctgactact ctgtgctcta caactctgcc      120

tccttcagca ccttcaagtg ttatggagtg agcccaacca aactgaatga cctgtgtttc      180

accaatgtct atgctgactc ctttgtgatt aggggagatg aggtgagaca gattgcccct      240

ggacaaacag gcaagattgc tgactacaac tacaaactgc ctgatgactt cacaggctgt      300

gtgattgcct ggaacagcaa caacctggac agcaagaagg gaggcaacta caactacctc      360

tacagactgt tcaggaagag caaactgaaa ccatttgaga gggacaccag catggagatt      420

taccaggctg gcaacacgcc atgtaatgga gtgaagggct tcaactgtta ctttccactc      480

caatcctatg gcttccgacc aacctatgga gtgggctacc aaccatacag ggtggtggtg      540

ctgtcctttg aactgctcca tgcccctgcc acagtgtgtg gaccaaag                   588


<210>  48
<211>  579
<212>  DNA
<213>  Artificial sequence

<220>
<223>  B71 nucleotide sequence

<400>  48
tgcccttttg gtgaagtttt taacgccacc aggtttgcct ctgtctatgc ctggaacagg       60

aagaggttta gcaactgtgt ggctgactac tcttggctct acaactctgc ctccttcagc      120

accttcaagt gttatggagt gagcccaacc aaactgaatg acctgtgttt caccaatgtc      180

tatgctgact cctttgtgat taggggagat gaggtggatc agattgcccc tggacaaaca      240

ggcgttattg ctgactacaa ctacaaactg cctgatgact tcacaggctg tgtgattgcc      300

tggaacagca acaacctgga cagcaagaag ggaggcaact acaactacct ctacagactg      360

ttcaggaaga gcaaactgaa accatttgag agggacacca gcatggagat ttaccaggct      420

ggcaacacgc catgtaatgg agtgaagggc ttcaactgtt actttccact ccaatcctat      480

ggcttccgac caacctatgg agtgggctac caaccataca gggtggtggt gctgtccttt      540

gaactgctcc atgcccctgc cacagtgtgt ggaccaaag                             579


