                         SEQUENCE LISTING

<110>  WORLD BIOTECH REGENERATIVE MEDICAL GROUP LIMITED
       MAN, Wing Yin Cornelia
       MA, Wei
       GAO, Quangui
 
<120>  METHODS AND COMPOSITIONS OF CAR-EXPRESSING NATURAL KILLER CELLS 
       WITH BISPECIFIC ANTIBODY AS CANCER THERAPEUTIC AGENTS

<130>  10132739-50738774 CAR NK

<150>  US 63/081,751
<151>  2020-09-22

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8 signaling peptide sequence

<400>  1
atgctcaggc tgctcttggc tctcaactta ttcccttcaa ttcaagtaac aggagggtct       60

tcg                                                                     63


<210>  2
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EGFR antibody sequence

<400>  2
ggacaggtta aattagagga gtcgggtggt ggcagcgtgc agacgggtgg tagtctgcgt       60

ttgacttgtg ctgcctccgg ccgcacgtcg cgttcttacg gtatgggctg gttccgccag      120

gctccaggca aggaacgtga atttgtatcc ggcatcagtt ggcgtgggga ctcaacaggt      180

tacgcagaca gcgtcaaagg tcgtttcacc atttcccgcg acaatgcgaa gaatacagtc      240

gacttgcaga tgaactccct gaaaccagaa gatacagcta tctactattg tgctgccgca      300

gccggatcag catggtatgg aacattgtac gaatatgact attggggcca gggtactcaa      360

gtgacggtat ctagc                                                       375


<210>  3
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CD8 hinge sequence

<400>  3
accacaacgc ccgctcctcg gccaccgacg ccagcgccaa ctattgcgag tcagcctctc       60

agtctgcgac ctgaggcttg tcgaccagca gccggaggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  4
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: The CD28 transmembrane domain, 4-1BB intracellular 
       domain, and CD3-zeta intracellular domain sequence

<400>  4
agaagacctc cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc       60

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggaaacg gggcagaaag      120

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      180

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact ggctagcctg      240

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      300

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      360

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      420

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      480

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      540

acctacgacg cccttcacat gcaggccctg ccccctcgcg ctagc                      585


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EGFR CAR F

<400>  5
agcgtcaaag gtcgtttcac                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: EGFR CAR R

<400>  6
ggctgactcg caatagttgg                                                   20


