                         SEQUENCE LISTING

<110>  Fondazione Istituto Italiano di Tecnologia
       Scuola Internazionale Superiore Di Studi Avanzati – SISSA
       TranSINE Therapeutics Limited
 
<120>  MODIFIED FUNCTIONAL NUCLEIC ACID MOLECULES

<130>  TSI-C-P2828PCT

<150>  EP 20425038.5
<151>  2020-09-24

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  RNA
<213>  Mus musculus


<220>
<223>  Full length inverted SINE B2 transposable element derived from AS
       Uchl1

<400>  1
gggcagugcu agaggagguc agaagagggc auuggauccc ccagaacugg aguuauacgg       60

uaaccucgug gugguuguga accaccaugu ggauggauau ugaguuccaa acacuggucc      120

ugugcaagag cauccagugc ucuuaagugc ugagccaucu cuuuagcucc agucucuuaa      180

gcu                                                                    183


<210>  2
<211>  167
<212>  RNA
<213>  Mus musculus


<220>
<223>  167nt inverted SINE B2 transposable element derived from AS Uchl1

<400>  2
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggagu uauacgguaa       60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcucc                    167


<210>  3
<211>  77
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 44-120 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  3
gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga       60

guuccaaaca cuggucc                                                      77


<210>  4
<211>  38
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 59-96 of inverted SINE B2 transposable element derived from AS
       Uchl1

<400>  4
gguaaccucg uggugguugu gaaccaccau guggaugg                               38


<210>  5
<211>  29
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 64-92 of inverted SINE B2 transposable element derived from AS
       Uchl1

<400>  5
ccucguggug guugugaacc accaugugg                                         29


<210>  6
<211>  61
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 52-112 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  6
guuauacggu aaccucgugg ugguugugaa ccaccaugug gauggauauu gaguuccaaa       60

c                                                                       61


<210>  7
<211>  98
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 36-133 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  7
aucccccaga acuggaguua uacgguaacc ucgugguggu ugugaaccac cauguggaug       60

gauauugagu uccaaacacu gguccugugc aagagcau                               98


<210>  8
<211>  129
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 22-150 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  8
gaagagggca uuggaucccc cagaacugga guuauacggu aaccucgugg ugguugugaa       60

ccaccaugug gauggauauu gaguuccaaa cacugguccu gugcaagagc auccagugcu      120

cuuaagugc                                                              129


<210>  9
<211>  67
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 44-110 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  9
gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga       60

guuccaa                                                                 67


<210>  10
<211>  107
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 34-140 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  10
ggauccccca gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga       60

uggauauuga guuccaaaca cugguccugu gcaagagcau ccagugc                    107


<210>  11
<211>  127
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 24-150 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  11
agagggcauu ggauccccca gaacuggagu uauacgguaa ccucguggug guugugaacc       60

accaugugga uggauauuga guuccaaaca cugguccugu gcaagagcau ccagugcucu      120

uaagugc                                                                127


<210>  12
<211>  116
<212>  RNA
<213>  Mus musculus


<220>
<223>  nt 27-142 of inverted SINE B2 transposable element derived from 
       AS Uchl1

<400>  12
gggcauugga ucccccagaa cuggaguuau acgguaaccu cguggugguu gugaaccacc       60

auguggaugg auauugaguu ccaaacacug guccugugca agagcaucca gugcuc          116


<210>  13
<211>  206
<212>  RNA
<213>  Artificial sequence


<220>
<223>  SINEUP 071 and miniSINEUP 071 effector domain

<400>  13
uuauuuuaaa uauaugagua uuucaccugc auaggcgcac aguacccaca gagacuagaa       60

gaggguagua gauccccuag aacuggaguu auacgguaac cucguggugg uugugagcua      120

ccauguggau ggauacuggg aaucaaaccc agguccugug gaaggcaggc aggugcucuc      180

aagcacugag ccaucucuuc agcucc                                           206


<210>  14
<211>  206
<212>  RNA
<213>  Artificial sequence


<220>
<223>  SINEUP 072 and miniSINEUP 072 effector domain

<400>  14
uuauuuuaaa uauaugagua uuucaccugc auaggcgcac agugcucaag gagaucagaa       60

gagggcauca gaucuccuga gacuggaguu auacgguaac cucgugaugg uugugaacua      120

ccauguggau ggauauugag uuccaaacac agguccugug caagagcagc aggugcucuu      180

aagcacggaa ccaucucuuu agcucc                                           206


<210>  15
<211>  156
<212>  RNA
<213>  Artificial sequence


<220>
<223>  SINEUP 073 and miniSINEUP 073 effector domain

<400>  15
gaggcuagaa gaggguauca gauccccuga gacuggaguu auacgguaac cucguggugg       60

uugugagcca ccauguggau ggauacugag aaccaaaccc ugguccugug caagagcauc      120

aggugcucuu aagcacggaa ccaucucuuc agcucc                                156


<210>  16
<211>  68
<212>  RNA
<213>  Artificial sequence


<220>
<223>  SINEUP 074 and miniSINEUP 074 effector domain

<400>  16
guccugugca agagcaucga acucggugcu cuuaagcaca gaagccacca agccaucucu       60

ucagcccc                                                                68


<210>  17
<211>  110
<212>  RNA
<213>  Artificial sequence


<220>
<223>  SINEUP 075 and miniSINEUP 075 effector domain

<400>  17
cagugcuaga ggaggucaga agagggcauc ccccagccuc guggugguug ugaaccacca       60

uguggcugug caagagcaug cucuuaagug cugagccauc ucuuuagcuc                 110


<210>  18
<211>  126
<212>  RNA
<213>  Artificial sequence


<220>
<223>  24-150 effector domain

<400>  18
gagggcauug gaucccccag aacuggaguu auacgguaac cucguggugg uugugaacca       60

ccauguggau ggauauugag uuccaaacac ugguccugug caagagcauc cagugcucuu      120

aagugc                                                                 126


<210>  19
<211>  89
<212>  RNA
<213>  Artificial sequence


<220>
<223>  C_34-122 effector domain

<400>  19
ggauccccca gaacuggagu uauacgguaa ccucguggug guugugaacc accaugugga       60

uggauauuga guuccaaaca cugguccug                                         89


<210>  20
<211>  72
<212>  RNA
<213>  Artificial sequence


<220>
<223>  TM effector domain

<400>  20
ugcuagagga ggucagaaga gggcauugga ugcaaaucca gugcucuuaa gugcugagcc       60

aucucuuuag cu                                                           72


<210>  21
<211>  94
<212>  RNA
<213>  Artificial sequence


<220>
<223>  MC2 effector domain

<400>  21
gagggcauug gaucccccag aacuggaguu auacgguaac gauggauauu gaguuccaaa       60

cacugguccu gugcaagagc auccagugcu cuua                                   94


<210>  22
<211>  180
<212>  RNA
<213>  Artificial sequence


<220>
<223>  G60A mutant of inverted SINE B2 transposable element derived from
       AS Uchl1

<400>  22
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggagu uauacgauaa       60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu      180


<210>  23
<211>  180
<212>  RNA
<213>  Artificial sequence


<220>
<223>  G60C mutant of inverted SINE B2 transposable element derived from
       AS Uchl1

<400>  23
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggagu uauacgcuaa       60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu      180


<210>  24
<211>  180
<212>  RNA
<213>  Artificial sequence


<220>
<223>  A51C mutant of inverted SINE B2 transposable element derived from
       AS Uchl1

<400>  24
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacuggcgu uauacgguaa       60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugguccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu      180


<210>  25
<211>  180
<212>  RNA
<213>  Artificial sequence


<220>
<223>  C47G and G117C mutant of inverted SINE B2 transposable element 
       derived from AS Uchl1

<400>  25
cagugcuaga ggaggucaga agagggcauu ggauccccca gaaguggagu uauacgguaa       60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cugcuccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu      180


<210>  26
<211>  180
<212>  RNA
<213>  Artificial sequence


<220>
<223>  46-49/115-118 stem swap mutant of inverted SINE B2 transposable 
       element derived from AS Uchl1

<400>  26
cagugcuaga ggaggucaga agagggcauu ggauccccca gauggugagu uauacgguaa       60

ccucguggug guugugaacc accaugugga uggauauuga guuccaaaca cgucaccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu      180


<210>  27
<211>  180
<212>  RNA
<213>  Artificial sequence


<220>
<223>  50-53 and 112-114 base swap mutant of inverted SINE B2 
       transposable element derived from AS Uchl1

<400>  27
cagugcuaga ggaggucaga agagggcauu ggauccccca gaacugcacu auacgguaac       60

cucguggugg uugugaacca ccauguggau ggauauugag uuccaaauga gugguccugu      120

gcaagagcau ccagugcucu uaagugcuga gccaucucuu uagcuccagu cucuuaagcu      180


<210>  28
<211>  77
<212>  RNA
<213>  Artificial sequence


<220>
<223>  nt 44-120 A45G mutant of inverted SINE B2 transposable element 
       derived from AS Uchl1

<400>  28
ggacuggagu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga       60

guuccaaaca cuggucc                                                      77


<210>  29
<211>  77
<212>  RNA
<213>  Artificial sequence


<220>
<223>  nt 44-120 A51C mutant of inverted sine B2 transposable element 
       derived from AS Uchl1

<400>  29
gaacuggcgu uauacgguaa ccucguggug guugugaacc accaugugga uggauauuga       60

guuccaaaca cuggucc                                                      77


<210>  30
<211>  77
<212>  RNA
<213>  Artificial sequence


<220>
<223>  44-120 U78G SINEUP

<400>  30
gaacuggagu uauacgguaa ccucguggug guugggaacc accaugugga uggauauuga       60

guuccaaaca cuggucc                                                      77


<210>  31
<211>  77
<212>  RNA
<213>  Artificial sequence


<220>
<223>  44-120 GUG77-79CCC SINEUP

<400>  31
gaacuggagu uauacgguaa ccucguggug guucccaacc accaugugga uggauauuga       60

guuccaaaca cuggucc                                                      77


<210>  32
<211>  77
<212>  RNA
<213>  Artificial sequence


<220>
<223>  44-120 SINEUP strong

<400>  32
ggaccggagu uauacgguaa ccgcguggug guugugaacc accacgcgga uggauauuga       60

guuccaaaca ccggucc                                                      77


<210>  33
<211>  77
<212>  RNA
<213>  Artificial sequence


<220>
<223>  44-120 SINEUP weak

<400>  33
gaacuagagu uauacgguaa ccacauggug guugugaacc accaugugga uggauauuga       60

guuccaaaca cuaguuc                                                      77


<210>  34
<211>  228
<212>  RNA
<213>  Mus musculus


<220>
<223>  SINEB2/B3 consensus sequence from RepBase

<400>  34
uuuuuuuaaa aauuuauuuu uauuuuaugu guaugagugu uuugccugca uguaugucug       60

uguaccacgu gcgugccugg ugcccgcgga ggccagaaga gggcgucgga uccccuggaa      120

cuggaguuac agaugguugu gagccgccau gugggugcug ggaaucgaac ccggguccuc      180

uggaagagca gccagugcuc uuaaccgcug agccaucucu ccagcccc                   228


<210>  35
<211>  107
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Txnip SINEB2

<400>  35
gaugccuuag aaguggaguu aagaguugug agcugccguu uuuugguucu gggacucgaa       60

cucguuuccu cugauacuau caaccaccaa gccaucucuu cagcccc                    107


<210>  36
<211>  131
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Uxt SINEB2 a

<400>  36
gccagaagaa guugugggau ucccuggaac uggagcaacc aacaguuugu gugcaccaug       60

uggguaaugg gaaucgaacc uggguccucu auaagacugg ccagugcucu uaacuacuga      120

ggugcauuuc u                                                           131


<210>  37
<211>  187
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Uxt SINEB2 b

<400>  37
uuauuuuaaa uauaugagua uuucaccugc auaggcgcac aguacccaca gagacuagaa       60

gaggguggca gaucuccuga gacuggaguu aaugcuugug agcugccaug uggaugcugg      120

aaaucaaacc cagguccuuu ggaaggcagg caggugcucu uaaucaugga agcaucucuu      180

cagcucc                                                                187


<210>  38
<211>  131
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Gadd45alpha SINEB2 a

<400>  38
cagcgacauc agaagaggau auuggauccc auuacagaug guugaaggcc accaugucgu       60

ugcugggaau gaacucaaga ccucuggaag agcagucagu gcucuuaacc ucugagccau      120

cucuccagcc c                                                           131


<210>  39
<211>  114
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Gadd45alpha SINEB2 b

<400>  39
auccccucca aagcucaaga ugguuguaag ccacccugug auugcuggga uuugaacuca       60

agaccuccgg aagagcaauu agugcucuua accgcugagc aaucucucca gccc            114


<210>  40
<211>  214
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Nars2 SINEB2/B3

<400>  40
uuuuuuuuac uuguauaggu guuuugccug cauguguauc uaucuaugua ccgaauaugu       60

uccugguauc cacagagacc aaaaguggau guuguaucuc cugaaauugg agucauagac      120

aguuaugagc ugccauuuga gugcuuggaa uagaacccag guccucuuaa agagcaucca      180

gugcucuuaa aaacugagac aucucuguag ccuc                                  214


<210>  41
<211>  200
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Abhd11 SINEB2/B3

<400>  41
uuuauuuugc uuuauguguc ugaguguuug cuugaaugua ugucugugua ccacgccugu       60

accuugugcc uucagaguug agaggagggc auaggaucuc cuggaacugg aauugcaggu      120

gguugugagc cacccugugg guccugggga ccauacucca gcaagaacau caugugcucu      180

uaauuccuga gucuccaacc                                                  200


<210>  42
<211>  214
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Ebp4.9 SINEB2/B3

<400>  42
uuuauuuacu uaucuuuaug uguaugagug uguugucaga cuguuauguc ugugugucac       60

augcaugccu gcuguucaug gaguccagaa gagggcaucg gauccccugg aacuggaguu      120

acagaugagu ggccauguga auguuaagaa ccaaaccugg guccucugaa agagcagaca      180

augcucuuaa cuacugagcu gucucuccag cccc                                  214


<210>  43
<211>  205
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Wfdc5 SINEB2/B3

<400>  43
uuauuuuauu cguguaagug uuuugccagc aucuaugucu ucgcacuaug ugcaggucug       60

gugccugagg gguccagacg agagcacugg gucuccggga acuggaguua cagaucauug      120

ugagccacca ugugggugca gggaaucgaa ccugggaccu cuggaggagc agccacugcu      180

cuuaaccacu acacuauuuc uccag                                            205


<210>  44
<211>  121
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Pgbd1 SINEB2/B3

<400>  44
ucuguggacc acuguguaca gaagccugag aaggcuagca gauccccaga acuggaacug       60

ugagacgcug ugcuauggag gugcuaggaa cugaaaaugg auggguccuc ugcaagagca      120

g                                                                      121


<210>  45
<211>  191
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Gsk3b SINEB2/B3

<400>  45
uuguuuuaau ugaauggcua uaggguguuu cuucuguaug uauaucuaug uuugguaccu       60

acagaggcau cagauccucu ggaacuguag uugcugacag uugugagcug ucauggggau      120

gcuggaauug aaccuggauc cuaugaaaga acagccagug uucuuaaccg cugagcuauc      180

ucuccaggcc c                                                           191


<210>  46
<211>  205
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Rhod SINEB2_Mm2

<400>  46
uuuuuuuuuu aauuuuaaaa aaaaagauuu uauuuauuua uuuuauauau gaugaguaca       60

cugucacucu uuucagacac ccuagaaaag gggggcauca gaucccauua cagaugguug      120

ugagccacau gguugcuggg aauugaccuc aggaccucug aaagagcagu cagugcucuc      180

aaccuuugag ucaucucucc agccc                                            205


<210>  47
<211>  190
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS Rhod SINEB2/B3A

<400>  47
auguauaucu guaaugggac auacucacau acaugggcac gugaguauaa aaggccagaa       60

gagagcacug gacccucugg aguugagauu cuaagcaguu gugaaccauc ugauguaggu      120

gcugggaacu gaacuugggu ccuuugcuag agaaguaugu cucuuaacca cugagccgua      180

ucuccauccc                                                             190


<210>  48
<211>  169
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS E4f1 SINEB2_Mm2

<400>  48
uaaagauuua uucauuaagu acacuguagc uaucuucaga cgcaucagaa gagggcguca       60

gaucucuuua caggugguug ugagccacca ugugguugcu ggaauuugaa cucaggaccu      120

ucaaaagagc agucaguguu cuuaaccgcu gagccaucuc uccaacccc                  169


<210>  49
<211>  159
<212>  RNA
<213>  Mus musculus


<220>
<223>  AS E4f1 SINEB2_Mm1t

<400>  49
uuauuuauua uaaguacacu guagcugucu ucagacacaa caaaagaggg cgucagaucu       60

cauuacaggu gguugagcca ccaugugguu gcugggauuu gaacucagga ccuucagaac      120

agucagugcu cuuacccacu gagccagcga gccagcccc                             159


<210>  50
<211>  13
<212>  RNA
<213>  Artificial sequence


<220>
<223>  Linker sequence

<400>  50
aucugcagaa uuc                                                          13


