                         SEQUENCE LISTING

<110>  UCL Business Ltd
 
<120>  ANTI-CD45 ANTIBODIES AND RELATED THERAPEUTICS

<130>  N409229WO

<150>  GB 2015235.1
<151>  2020-09-25

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable domain of YTH 24.5 (Ab1)

<400>  1

Asp Val Val Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Phe Val Ser Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu His Asp Asp Leu Gly Val Tyr Tyr Cys Gly Gln Ala 
                85                  90                  95      


Ser Lys Ile Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable domain of YTH 24.5 (Ab1)

<400>  2

Gln Val Asn Leu Leu Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Ser Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Ser Arg Leu Thr Ser Glu Asp Ser Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Thr Gly Val Ile Pro Met Asp Ala Trp Gly Gln Gly Ala 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of YTH 24.5 (Ab1)

<400>  3

Arg Ser Ser Gln Ser Phe Val Ser Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of YTH 24.5 (Ab1)

<400>  4

Lys Val Ser Asn Arg Leu Ser 
1               5           


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of YTH 24.5 (Ab1)

<400>  5

Gly Gln Ala Ser Lys Ile Pro Leu Thr 
1               5                   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of YTH 24.5 (Ab1)

<400>  6

Asp Tyr Tyr Ile His 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of YTH 24.5 (Ab1)

<400>  7

Tyr Ile Asn Pro Lys Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Arg 
    


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of YTH 24.5 (Ab1)

<400>  8

Arg Thr Gly Val Ile Pro Met Asp Ala 
1               5                   


<210>  9
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of rat IgG2b YTH 24.5 (rat IgG2b Ab1)

<400>  9

Asp Val Val Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Phe Val Ser Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu His Asp Asp Leu Gly Val Tyr Tyr Cys Gly Gln Ala 
                85                  90                  95      


Ser Lys Ile Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Met Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Thr Val Val Cys Phe Val Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Asp Ile Ser Val Lys Trp Lys Ile Asp Gly Ser Glu Gln 
145                 150                 155                 160 


Arg Asp Gly Val Leu Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Ser Leu Thr Lys Val Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Leu Tyr Thr Cys Glu Val Val His Lys Thr Ser Ser Ser 
        195                 200                 205             


Pro Val Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  10
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of rat IgG2b YTH 24.5 (rat IgG2b Ab1)

<400>  10

Gln Val Asn Leu Leu Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Ser Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Ser Arg Leu Thr Ser Glu Asp Ser Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Thr Gly Val Ile Pro Met Asp Ala Trp Gly Gln Gly Ala 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Gln Thr Thr Ala Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Cys Gly Asp Thr Thr Ser Ser Thr Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Ser Ser Asp Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Gly Leu Tyr Thr Leu Thr Ser Ser Val Thr Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Arg Arg Asn Gly Gly Ile Gly His Lys Cys 
    210                 215                 220                 


Pro Thr Cys Pro Thr Cys His Lys Cys Pro Val Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Leu 
                245                 250                 255     


Ile Ser Gln Asn Ala Lys Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Glu Glu Pro Asp Val Gln Phe Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Pro Lys Gly Leu Val Arg Lys Pro Gln Val 
            340                 345                 350         


Tyr Val Met Gly Pro Pro Thr Glu Gln Leu Thr Glu Gln Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Thr Ser Gly Phe Leu Pro Asn Asp Ile Gly Val Glu 
    370                 375                 380                 


Trp Thr Ser Asn Gly His Ile Glu Lys Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Met Asp Ser Asp Gly Ser Phe Phe Met Tyr Ser Lys Leu Asn Val 
                405                 410                 415     


Glu Arg Ser Arg Trp Asp Ser Arg Ala Pro Phe Val Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Val Glu Lys Ser Ile Ser Arg Pro 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable domain of YTH 54.12 (Ab2)

<400>  11

Asp Val Gln Met Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Lys Ala Ser Lys Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Asn Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Arg Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Glu Lys Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable domain of YTH 54.12 (Ab2)

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Met Ser Phe Ala Gly Ser Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Tyr Thr Thr Asp Tyr Tyr Leu Tyr Trp Tyr Phe Asp Phe 
            100                 105                 110         


Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of YTH 54.12 (Ab2)

<400>  13

Lys Ala Ser Lys Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of YTH 54.12 (Ab2)

<400>  14

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of YTH 54.12 (Ab2)

<400>  15

Gln Gln Tyr Asp Glu Lys Pro Leu Thr 
1               5                   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of YTH 54.12 (Ab2)

<400>  16

Asp Tyr Tyr Met Ala 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of YTH 54.12 (Ab2)

<400>  17

Ser Met Ser Phe Ala Gly Ser Ser Thr Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of YTH 54.12 (Ab2)

<400>  18

Met Tyr Thr Thr Asp Tyr Tyr Leu Tyr Trp Tyr Phe Asp Phe 
1               5                   10                  


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of rat IgG2b YTH 54.12 (rat IgG2b Ab2)

<400>  19

Asp Val Gln Met Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Lys Ala Ser Lys Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Asn Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Arg Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Glu Lys Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Met Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Thr Val Val Cys Phe Val Asn Asn Phe Tyr Pro Arg Asp Ile 
    130                 135                 140                 


Ser Val Lys Trp Lys Ile Asp Gly Ser Glu Gln Arg Asp Gly Val Leu 
145                 150                 155                 160 


Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Ser Leu Thr Lys Val Glu Tyr Glu Arg His Asn Leu Tyr 
            180                 185                 190         


Thr Cys Glu Val Val His Lys Thr Ser Ser Ser Pro Val Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  20
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of rat IgG2b YTH 54.12 (rat IgG2b Ab2)

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Met Ser Phe Ala Gly Ser Ser Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Tyr Thr Thr Asp Tyr Tyr Leu Tyr Trp Tyr Phe Asp Phe 
            100                 105                 110         


Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser Ala Gln Thr Thr Ala 
        115                 120                 125             


Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Ser Ser 
    130                 135                 140                 


Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Ala Leu Ser Ser Asp Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu Thr Ser Ser Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Val Glu Arg Arg Asn Gly Gly 
    210                 215                 220                 


Ile Gly His Lys Cys Pro Thr Cys Pro Thr Cys His Lys Cys Pro Val 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Ile Leu Leu Ile Ser Gln Asn Ala Lys Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Glu Glu Glu Pro Asp Val Gln Phe Ser Trp Phe Val 
        275                 280                 285             


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Phe Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
305                 310                 315                 320 


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Lys Gly Leu Val 
            340                 345                 350         


Arg Lys Pro Gln Val Tyr Val Met Gly Pro Pro Thr Glu Gln Leu Thr 
        355                 360                 365             


Glu Gln Thr Val Ser Leu Thr Cys Leu Thr Ser Gly Phe Leu Pro Asn 
    370                 375                 380                 


Asp Ile Gly Val Glu Trp Thr Ser Asn Gly His Ile Glu Lys Asn Tyr 
385                 390                 395                 400 


Lys Asn Thr Glu Pro Val Met Asp Ser Asp Gly Ser Phe Phe Met Tyr 
                405                 410                 415     


Ser Lys Leu Asn Val Glu Arg Ser Arg Trp Asp Ser Arg Ala Pro Phe 
            420                 425                 430         


Val Cys Ser Val Val His Glu Gly Leu His Asn His His Val Glu Lys 
        435                 440                 445             


Ser Ile Ser Arg Pro Pro Gly Lys 
    450                 455     


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR1 of YTH 24.5 (Ab1)

<400>  21

Asp Val Val Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Gln Val Ser Ile Ser Cys 
            20              


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR2 of YTH 24.5 (Ab1)

<400>  22

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR3 of YTH 24.5 (Ab1)

<400>  23

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu His Asp Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR4 of YTH 24.5 (Ab1)

<400>  24

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR1 of YTH 24.5 (Ab1)

<400>  25

Gln Val Asn Leu Leu Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Ser Tyr Thr Phe Thr 
            20                  25                  30  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR2 of YTH 24.5 (Ab1)

<400>  26

Trp Val Lys Gln Ser His Gly Lys Thr Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR3 of YTH 24.5 (Ab1)

<400>  27

Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr Met Asp 
1               5                   10                  15      


Ile Ser Arg Leu Thr Ser Glu Asp Ser Ala Thr Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR4 of YTH 24.5 (Ab1)

<400>  28

Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR1 of YTH 54.12 (Ab2)

<400>  29

Asp Val Gln Met Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys 
            20              


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR2 of YTH 54.12 (Ab2)

<400>  30

Trp Tyr Gln Gln Lys Pro Gly Glu Ala Asn Lys Ile Leu Ile Tyr 
1               5                   10                  15  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR3 of YTH 54.12 (Ab2)

<400>  31

Gly Thr Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
1               5                   10                  15      


Leu Thr Ile Arg Asn Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCFR4 of YTH 54.12 (Ab2)

<400>  32

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  33
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR1 of YTH 54.12 (Ab2)

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR2 of YTH 54.12 (Ab2)

<400>  34

Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  35
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR3 of YTH 54.12 (Ab2)

<400>  35

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCFR4 of YTH 54.12 (Ab2)

<400>  36

Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  37
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


<210>  38
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Ser Pro Thr Pro Ser Pro Thr Gly Leu Thr Thr Ala Lys Met Pro 
1               5                   10                  15      


Ser Val Pro Leu Ser Ser Asp Pro Leu Pro Thr His Thr Thr Ala Phe 
            20                  25                  30          


Ser Pro Ala Ser Thr Phe Glu Arg Glu Asn Asp Phe Ser Glu Thr Thr 
        35                  40                  45              


Thr Ser Leu Ser Pro Asp Asn Thr Ser Thr Gln Val Ser Pro Asp Ser 
    50                  55                  60                  


Leu Asp Asn Ala Ser Ala Phe Asn Thr Thr Gly Val Ser Ser Val Gln 
65                  70                  75                  80  


Thr Pro His Leu Pro Thr His Ala Asp Ser Gln Thr Pro Ser Ala Gly 
                85                  90                  95      


Thr Asp Thr Gln Thr Phe Ser Gly Ser Ala Ala Asn Ala Lys Leu Asn 
            100                 105                 110         


Pro Thr Pro Gly Ser Asn Ala Ile Ser Asp Val Pro Gly Glu Arg Ser 
        115                 120                 125             


Thr Ala Ser Thr Phe Pro Thr Asp Pro Val Ser Pro Leu Thr Thr Thr 
    130                 135                 140                 


Leu Ser Leu Ala His His Ser Ser Ala Ala Leu Pro Ala Arg Thr Ser 
145                 150                 155                 160 


Asn Thr Thr Ile Thr Ala Asn Thr Ser Asp Ala Tyr Leu Asn Ala Ser 
                165                 170                 175     


Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser Ala Val Ile Ser Thr Thr 
            180                 185                 190         


Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala 
        195                 200                 205             


Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr 
    210                 215                 220                 


Ala Lys Leu Asn Val Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys 
225                 230                 235                 240 


Thr Asn Asn Glu Val His Asn Leu Thr Glu Cys Lys Asn Ala Ser Val 
                245                 250                 255     


Ser Ile Ser His Asn Ser Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu 
            260                 265                 270         


Asp Val Pro Pro Gly Val Glu Lys Phe Gln Leu His Asp Cys Thr Gln 
        275                 280                 285             


Val Glu Lys Ala Asp Thr Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu 
    290                 295                 300                 


Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly 
305                 310                 315                 320 


Asn Met Ile Phe Asp Asn Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro 
                325                 330                 335     


Glu His Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys 
            340                 345                 350         


Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly 
        355                 360                 365             


Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu Ala Ala His Gln Gly Val 
    370                 375                 380                 


Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys 
385                 390                 395                 400 


Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu 
                405                 410                 415     


Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu 
            420                 425                 430         


Ser Leu His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Ser Ala 
        435                 440                 445             


Ala Met Cys His Phe Thr Thr Lys Ser Ala Pro Pro Ser Gln Val Trp 
    450                 455                 460                 


Asn Met Thr Val Ser Met Thr Ser Asp Asn Ser Met His Val Lys Cys 
465                 470                 475                 480 


Arg Pro Pro Arg Asp Arg Asn Gly Pro His Glu Arg Tyr His Leu Glu 
                485                 490                 495     


Val Glu Ala Gly Asn Thr Leu Val Arg Asn Glu Ser His Lys Asn Cys 
            500                 505                 510         


Asp Phe Arg Val Lys Asp Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys 
        515                 520                 525             


Ala Tyr Phe His Asn Gly Asp Tyr Pro Gly Glu Pro Phe Ile Leu His 
    530                 535                 540                 


His Ser Thr Ser Tyr Asn Ser Lys 
545                 550         


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesised sequence - C-terminus sequence for sortase 
       conjugation

<400>  39

Gly Gly Gly Gly Ser Leu Pro Glu Thr Gly Gly Trp Ser His Pro Gln 
1               5                   10                  15      


Phe Glu Lys 
            


<210>  40
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesised sequence, V5-CD45 FL with signal peptide

<400>  40

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gly Lys Pro Ile Pro Asn Pro 
            20                  25                  30          


Leu Leu Gly Leu Asp Ser Thr Gln Ser Pro Thr Pro Ser Pro Thr Gly 
        35                  40                  45              


Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp Pro Leu 
    50                  55                  60                  


Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu Arg Glu 
65                  70                  75                  80  


Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn Thr Ser 
                85                  90                  95      


Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe Asn Thr 
            100                 105                 110         


Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
        115                 120                 125             


Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
    130                 135                 140                 


Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
145                 150                 155                 160 


Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 
                165                 170                 175     


Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 
            180                 185                 190         


Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 
        195                 200                 205             


Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
    210                 215                 220                 


Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
225                 230                 235                 240 


Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
                245                 250                 255     


Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
            260                 265                 270         


Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
        275                 280                 285             


Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
    290                 295                 300                 


Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
305                 310                 315                 320 


Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
                325                 330                 335     


Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
            340                 345                 350         


Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
        355                 360                 365             


Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
    370                 375                 380                 


Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
385                 390                 395                 400 


Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
                405                 410                 415     


Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
            420                 425                 430         


Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
        435                 440                 445             


Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
    450                 455                 460                 


Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
465                 470                 475                 480 


Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
                485                 490                 495     


Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
            500                 505                 510         


Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
        515                 520                 525             


His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
    530                 535                 540                 


Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
545                 550                 555                 560 


Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
                565                 570                 575     


Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
            580                 585                 590         


Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
        595                 600                 605             


Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
    610                 615                 620                 


Asn Leu Asp Glu Gln Gln Glu 
625                 630     


<210>  41
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesised sequence, V5-CD45 delta 2 truncation mutant with signal 
       peptide

<400>  41

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gly Lys Pro Ile Pro Asn Pro 
            20                  25                  30          


Leu Leu Gly Leu Asp Ser Thr Ser Pro Gly Glu Pro Gln Ile Ile Phe 
        35                  40                  45              


Cys Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro 
    50                  55                  60                  


Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu 
65                  70                  75                  80  


Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln 
                85                  90                  95      


Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile 
            100                 105                 110         


Ile Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr 
        115                 120                 125             


Thr Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met 
    130                 135                 140                 


Thr Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg 
145                 150                 155                 160 


Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr 
                165                 170                 175     


Leu Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp 
            180                 185                 190         


Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly 
        195                 200                 205             


Asp Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn 
    210                 215                 220                 


Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser 
225                 230                 235                 240 


Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys 
                245                 250                 255     


Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu 
            260                 265     


