                         SEQUENCE LISTING

<110>  Merus N.V.
 
<120>  METHOD FOR DETECTING EXPRESSION OR CLUSTERING OF CELL SURFACE 
       MOIETIES

<130>  P4023PC00

<140>  NL 2026558
<141>  2020-09-28

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Ala Met Asn Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Gly Val Ile Gly Gly His Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 1

<400>  2

Asn Phe Ala Met Asn 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 1

<400>  3

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 1

<400>  4

Asp Trp Gly Val Ile Gly Gly His Tyr Met Asp Val 
1               5                   10          


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Asp Gly Tyr Gly Pro Lys Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 5

<400>  6

Ser Tyr Gly Ile Ser 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 5

<400>  7

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 5

<400>  8

Asp Ser Asp Gly Tyr Gly Pro Lys Ala Phe Asp Tyr 
1               5                   10          


<210>  9
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Phe Tyr Thr Gly Ile Val Gly Ala Thr Gly Ala Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 9

<400>  10

Ser Tyr Trp Ile Gly 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 9

<400>  11

Ile Ile Tyr Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 9

<400>  12

Phe Tyr Thr Gly Ile Val Gly Ala Thr Gly Ala Phe Asp Val 
1               5                   10                  


<210>  13
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Met Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Ala Thr Tyr Tyr Tyr Gly Ser Gly Thr Tyr Tyr Ser Ile 
            100                 105                 110         


Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 13

<400>  14

Ser Asp Ala Ile Ser 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 13

<400>  15

Gly Met Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 13

<400>  16

Gly Ala Thr Tyr Tyr Tyr Gly Ser Gly Thr Tyr Tyr Ser Ile Asn Trp 
1               5                   10                  15      


Phe Asp Pro 
            


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Tyr Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Ala Ser Val Met Val Arg Gly Asp Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 17

<400>  18

Asn Phe Ala Met Thr 
1               5   


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 17

<400>  19

Asp Trp Ala Ser Val Met Val Arg Gly Asp Leu Asp Tyr 
1               5                   10              


<210>  20
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Ser Glu Leu 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Val Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Tyr Pro Glu Asp Val Glu Pro Ile Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Gly Phe Asp Asn Tyr Gly Ser Gly Ile Arg Gly Asn Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 20

<400>  21

Glu Leu Ser Ile His 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 20

<400>  22

Gly Phe Tyr Pro Glu Asp Val Glu Pro Ile Tyr Ala Arg Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 20

<400>  23

Glu Gly Phe Asp Asn Tyr Gly Ser Gly Ile Arg Gly Asn Trp Phe Asp 
1               5                   10                  15      


Pro 
    


<210>  24
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Phe Tyr Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Glu Asp Thr Ser Ala Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Gly Val Gly Val Ile Arg Gly Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 24

<400>  25

Glu Leu Ser Met His 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 24

<400>  26

Ser Phe Tyr Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 24

<400>  27

Glu Gly Val Gly Val Ile Arg Gly Asn Trp Phe Asp Pro 
1               5                   10              


<210>  28
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Phe Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Leu Gly Gly Tyr Ser Gly Tyr Ala Glu Asp Phe Val Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 28

<400>  29

Ile Ile Phe Pro Asp Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 28

<400>  30

Leu Gly Gly Tyr Ser Gly Tyr Ala Glu Asp Phe Val Asp Phe 
1               5                   10                  


<210>  31
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Lys Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Glu Pro Glu Asp Gly Glu Thr Ile Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Arg Leu Gly Ala Ser Tyr Tyr Tyr Ser Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 31

<400>  32

Lys Leu Ser Met His 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 31

<400>  33

Gly Phe Glu Pro Glu Asp Gly Glu Thr Ile Asn Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 31

<400>  34

Asp Leu Arg Leu Gly Ala Ser Tyr Tyr Tyr Ser Tyr Met Asp Val 
1               5                   10                  15  


<210>  35
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  35

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Ser Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Tyr Phe Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Leu Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Thr Leu Trp Gly Ser Asp Asp Val Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 35

<400>  36

Thr Ser Gly Met Ser Val Gly 
1               5           


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 35

<400>  37

Leu Ile Tyr Trp Asn Asp Asp Lys Tyr Phe Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 35

<400>  38

Thr Leu Trp Gly Ser Asp Asp Val Phe Asp Val 
1               5                   10      


<210>  39
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  39

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp His Thr Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gln Gly Tyr Ser Phe Ser Gly Ser His Ile Asp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 39

<400>  40

Asn Tyr Trp Ile Gly 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 39

<400>  41

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 39

<400>  42

His Gln Gly Tyr Ser Phe Ser Gly Ser His Ile Asp Asp Tyr 
1               5                   10                  


<210>  43
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  43

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ala Gly Phe Ile Ile Thr Ser Gln Asn Ile Asp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 43

<400>  44

Thr Tyr Trp Ile Gly 
1               5   


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 43

<400>  45

His Ala Gly Phe Ile Ile Thr Ser Gln Asn Ile Asp Asp Tyr 
1               5                   10                  


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Asp Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Gly Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Gly Leu Val Ala Ile Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 46

<400>  47

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Asp Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 46

<400>  48

Asp Trp Gly Leu Val Ala Ile Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  49
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  49

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Thr 
            20                  25                  30          


Gly Val Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Glu Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Glu Gly Ile Ile Gly Phe Leu Gly Gly Asn Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 49

<400>  50

Thr Thr Gly Val Gly Val Asn 
1               5           


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 49

<400>  51

Leu Ile Tyr Trp Asn Asp Asp Thr Tyr Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 49

<400>  52

Glu Gly Ile Ile Gly Phe Leu Gly Gly Asn Trp Phe Asp Pro 
1               5                   10                  


<210>  53
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Lys Tyr Val Thr Asn Trp Val Phe Ala Glu Asp Phe 
            100                 105                 110         


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 53

<400>  54

Ser His Ala Met Asn 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 53

<400>  55

Trp Ile Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 53

<400>  56

Asp Arg Lys Tyr Val Thr Asn Trp Val Phe Ala Glu Asp Phe Gln His 
1               5                   10                  15      


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp Arg Gly Tyr Met Ser Asn Trp Val Phe Ala Glu Tyr Phe 
            100                 105                 110         


Pro His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 57

<400>  58

Asp Arg Gly Tyr Met Ser Asn Trp Val Phe Ala Glu Tyr Phe Pro His 
1               5                   10                  15      


<210>  59
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Gly Tyr Ile Ser Ser Trp Val Phe Ala Glu Asp Phe 
            100                 105                 110         


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 59

<400>  60

Ser Tyr Ala Met Asn 
1               5   


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 59

<400>  61

Asp Arg Gly Tyr Ile Ser Ser Trp Val Phe Ala Glu Asp Phe Gln His 
1               5                   10                  15      


<210>  62
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Ala Cys Val Asn Pro Asn Thr Gly Ser Pro Thr Tyr Ala Gln Gly Ser 
    50                  55                  60                  


Thr Gly Arg Phe Val Val Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Lys Tyr Val Thr Asn Trp Val Phe Ala Glu Asp Phe 
            100                 105                 110         


Gln His Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 62

<400>  63

Cys Val Asn Pro Asn Thr Gly Ser Pro Thr Tyr Ala Gln Gly Ser Thr 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Ser 
    50                  55                  60                  


Thr Gly Arg Phe Val Val Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Lys Tyr Val Thr Asn Trp Val Phe Ala Glu Asp Phe 
            100                 105                 110         


Gln His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 64

<400>  65

Asn Tyr Ala Met Asn 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 64

<400>  66

Trp Met Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Ser Thr 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Lys Tyr Val Thr Asn Trp Val Phe Ala Glu Asp Phe 
            100                 105                 110         


Gln His Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 67

<400>  68

Asn Tyr Ala Ile Asn 
1               5   


<210>  69
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  69

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Val Pro Ile Phe Gly Thr Ile Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Thr Met Val Arg Gly Val Asp Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 69

<400>  70

Thr Tyr Ser Ile Thr 
1               5   


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 69

<400>  71

Ser Ile Val Pro Ile Phe Gly Thr Ile Asn Asn Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 69

<400>  72

Asp Asn Thr Met Val Arg Gly Val Asp Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  73
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  73

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Val Arg Gly Tyr Ser Ala Tyr Asp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 73

<400>  74

Thr Tyr Ala Ile Ser 
1               5   


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 73

<400>  75

Gly Ile Ile Pro Ile Phe Asp Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 73

<400>  76

Asn Val Arg Gly Tyr Ser Ala Tyr Asp Leu Asp Tyr 
1               5                   10          


<210>  77
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Asn Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Thr Gly Gly Thr Phe Asn Thr Tyr 
            20                  25                  30          


Gly Thr Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Asp Met Gly Thr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 77

<400>  78

Thr Tyr Gly Thr Asn 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 77

<400>  79

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 77

<400>  80

Gly Gly Ala Asp Met Gly Thr Leu Asp Tyr 
1               5                   10  


<210>  81
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  81

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Met Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr 
            20                  25                  30          


Thr Ile Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Pro Asn Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Cys Asn His Gly Val Cys Tyr Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 81

<400>  82

Thr Tyr Thr Ile Ile 
1               5   


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 81

<400>  83

Gly Ile Ile Pro Ile Phe Asp Thr Pro Asn Phe Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 81

<400>  84

Glu Gly Cys Asn His Gly Val Cys Tyr Pro Tyr 
1               5                   10      


<210>  85
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Tyr Ser Asn Pro His Trp Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 85

<400>  86

Ser Tyr Gly Ile Thr 
1               5   


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 85

<400>  87

Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 85

<400>  88

Arg Arg Gly Tyr Ser Asn Pro His Trp Leu Asp Pro 
1               5                   10          


<210>  89
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Leu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ile Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Asn Tyr Tyr Glu Phe Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 89

<400>  90

Thr Tyr Gly Ile Leu 
1               5   


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 89

<400>  91

Gly Gly Gly Asn Tyr Tyr Glu Phe Val Tyr 
1               5                   10  


<210>  92
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  92

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Thr Gly Tyr Ser Ser Ser Asn Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 according to KABAT  from SEQ ID NO: 92

<400>  93

Thr Tyr Ala Ile Asn 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 92

<400>  94

Arg Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 92

<400>  95

Asp Glu Thr Gly Tyr Ser Ser Ser Asn Phe Gln His 
1               5                   10          


<210>  96
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Lys Tyr Val Thr Asn Trp Val Phe Ala Glu Asp Phe 
            100                 105                 110         


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  97
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Thr Ser Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Phe Ser Ser Ser Ser Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 97

<400>  98

Gly Ile Ile Pro Val Phe Gly Thr Ser Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  99
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 97

<400>  99

Asp Pro Ser Phe Ser Ser Ser Ser Gly Trp Phe Asp Pro 
1               5                   10              


<210>  100
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN VARIABLE REGION

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Gln Thr Gly Tyr Ser Ser Thr Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 100

<400>  101

Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 100

<400>  102

Asp Gln Thr Gly Tyr Ser Ser Thr Leu Phe Asp Tyr 
1               5                   10          


<210>  103
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp Arg Gly Tyr Met Ser Asn Trp Val Phe Ala Glu Tyr Phe 
            100                 105                 110         


Pro His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  104
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  104

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ile Pro Ile Phe Asp Thr Gly Asn Tyr Ala Gln Lys Ile 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Thr Asn Thr Val Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 104

<400>  105

Trp Ile Ile Pro Ile Phe Asp Thr Gly Asn Tyr Ala Gln Lys Ile Gln 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 according to KABAT  from SEQ ID NO: 104

<400>  106

His Asp Tyr Thr Asn Thr Val Asp Ala Phe Asp Ile 
1               5                   10          


<210>  107
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable region

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Tyr Ser Asn Pro His Trp Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 according to KABAT  from SEQ ID NO: 107

<400>  108

Gly Ile Ile Pro Val Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human common light chain IGKV1-39/jk1

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of common light chain variable domain

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 according to KABAT  from SEQ ID NO: 110

<400>  111

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 according to KABAT  from SEQ ID NO: 110

<400>  112

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 according to KABAT  from SEQ ID NO: 110

<400>  113

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  114
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of common light chain constant domain

<400>  114

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of light chain constant domain

<400>  115

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  116
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CH1

<400>  116

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the hinge

<400>  117

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  118
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CH2

<400>  118

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  119
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CH3 with KK mutations

<400>  119

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  120
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of CH3 with DE mutations

<400>  120

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Glu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         

   


