                         SEQUENCE LISTING

<110>  FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
       UNIVERSITAT DE BARCELONA
       HOSPITAL DE SANT JOAN DE DEU
 
<120>  Peptidic conjugates of SN38 useful in the treatment of cancer

<130>  P5482EP00

<150>  EP20382854.6
<151>  2020-09-28

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is selected from the group consisting of Dpr and Dbu,  and it
       is bound to amino acid at position 9 through an amide 
       intrapeptide bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is selected from the group consisting of Asp and Glu,  and it
       is bound to amino acid at position 1 through an amide 
       intrapeptide bond

<400>  1

Xaa Lys Ala Pro Glu Thr Ala Leu Xaa 
1               5                   


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 9 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  it is bound to the amino acid at position 9 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 1 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  it is bound to the amino acid at position 1 by a disulfide or 
       diselenide intrapeptide bond

<400>  2

Xaa Lys Ala Pro Glu Thr Ala Leu Xaa Ala Ala Ala 
1               5                   10          


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 9 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  it is bound to the amino acid at position 9 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 1 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  it is bound to the amino acid at position 1 by a disulfide or 
       diselenide intrapeptide bond

<400>  3

Xaa Lys Ala Pro Glu Thr Ala Leu Xaa 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 9 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  it is bound to the amino acid at position 9 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 1 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  it is bound to the amino acid at position 1 by a disulfide or 
       diselenide intrapeptide bond

<400>  4

Xaa Lys Ala Pro Glu Thr Ala Leu Xaa Ala 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 9 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  it is bound to the amino acid at position 9 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 1 and it is selected from cysteine, selenocysteine, and 
       penicillamine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  it is bound to the amino acid at position 1 by a disulfide or 
       diselenide intrapeptide bond

<400>  5

Xaa Lys Ala Pro Glu Thr Ala Leu Xaa Ala Ala 
1               5                   10      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 11, and it is selected from the group consisting of 
       cysteine, selenocysteine, and penicillamine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  it is bound to the amino acid at position 11 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 15, and it is selected from the group consisting of 
       cysteine, selenocysteine, and penicillamine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  it is bound to the amino acid at position 15 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 1 and it is selected from the group consisting of 
       cysteine, selenocysteine, and penicillamine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  it is bound to the amino acid at position 1 by a disulfide or 
       diselenide intrapeptide bond

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is an amino acid which is the same as the amino acid at 
       position 3, and it is selected from the group consisting of 
       cysteine, selenocysteine, and penicillamine

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  it is bound to the amino acid at position 3 by a disulfide or 
       diselenide intrapeptide bond

<400>  6

Xaa Asn Xaa Lys Ala Pro Glu Thr Ala Leu Xaa Ala Ala Ala Xaa His 
1               5                   10                  15      


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from Dpr and Dpu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is selected from Glu and Asp

<400>  7

Xaa Lys Ala Pro Glu Thr Ala Leu Xaa 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa represents Dap, and it is bound to the amino acid at position
       9 by an amide intrapeptide bond

<400>  8

Xaa Lys Ala Pro Glu Thr Ala Leu Asp 
1               5                   


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  9

Cys Lys Ala Pro Glu Thr Ala Leu Cys Ala Ala Ala 
1               5                   10          


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  10

Cys Lys Ala Pro Glu Thr Ala Leu Cys 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  11

Cys Lys Ala Pro Glu Thr Ala Leu Cys Ala 
1               5                   10  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  DISULFID
<222>  (1)..(9)

<400>  12

Cys Lys Ala Pro Glu Thr Ala Leu Cys Ala Ala 
1               5                   10      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  DISULFID
<222>  (1)..(11)

<220>
<221>  DISULFID
<222>  (3)..(15)

<400>  13

Cys Asn Cys Lys Ala Pro Glu Thr Ala Leu Cys Ala Ala Ala Cys His 
1               5                   10                  15      


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa means Dpr

<400>  14

Xaa Lys Ala Pro Glu Thr Ala Leu Asp 
1               5                   


