                         SEQUENCE LISTING

<110>  Medigene Immunotherapies GmbH
 
<120>  Novel PRAME receptors and uses thereof

<130>  M11794WO

<150>  EP20198096.8
<151>  2020-09-24

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  1
ctctatgtgg actctttatt tttcctt                                           27


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   


<210>  3
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  3
aaggccctgt acagc                                                        15


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Ala Leu Tyr Ser 
1               5   


<210>  5
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  5
gagaaccatc ggtac                                                        15


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Asn His Arg Tyr 
1               5   


<210>  7
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7
ctgctgaaag gcggcgagca g                                                 21


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Leu Lys Gly Gly Glu Gln 
1               5           


<210>  9
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  9
agctacggcg tgaaggac                                                     18


<210>  10
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  10

Ser Tyr Gly Val Lys Asp 
1               5       


<210>  11
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  11
tgcggcacag ccaatagcgg cggcagcaac tacaagctga ccttc                       45


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Gly Thr Ala Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
1               5                   10                  15  


<210>  13
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  13
tgcgccatca gcgactacga gggcaccgag gcctttttt                              39


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Ala Ile Ser Asp Tyr Glu Gly Thr Glu Ala Phe Phe 
1               5                   10              


<210>  15
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  15
atggagacac tgctgaaggt gctgtctggc acactgctgt ggcagctgac ctgggtccga       60

tctcagcagc ctgttcagtc tcctcaggcc gtgatcctga gagaaggcga ggacgccgtg      120

atcaactgca gcagctctaa ggccctgtac agcgtgcact ggtacagaca gaagcacggc      180

gaggcccctg tgttcctgat gatcctgctg aaaggcggcg agcagaaggg ccacgagaag      240

atcagcgcca gcttcaacga gaagaagcag cagtccagcc tgtacctgac agccagccag      300

ctgagctaca gcggcaccta cttttgcggc acagccaata gcggcggcag caactacaag      360

ctgaccttcg gcaagggcac cctgctgacc gtgaatccca at                         402


<210>  16
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
            100                 105                 110         


Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu 
        115                 120                 125             


Leu Thr Val Asn Pro Asn 
    130                 


<210>  17
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  17
atgggcacca gactgttctt ctacgtggcc ctgtgtctgc tgtggacagg ccatgtggat       60

gccggaatca cacagagccc cagacacaaa gtgaccgaga caggcacccc tgtgacactg      120

agatgtcacc agaccgagaa ccatcggtac atgtattggt acagacagga ccccggccac      180

ggcctgagac tgatccacta tagctacggc gtgaaggaca ccgacaaggg cgaagtgtct      240

gacggctaca gcgtgtccag aagcaagacc gaggacttcc tgctgaccct ggaaagcgcc      300

acaagcagcc agaccagcgt gtacttctgc gccatcagcg actacgaggg caccgaggcc      360

ttttttggcc aaggcacaag actgaccgtg gtg                                   393


<210>  18
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Thr 
1               5                   10                  15      


Gly His Val Asp Ala Gly Ile Thr Gln Ser Pro Arg His Lys Val Thr 
            20                  25                  30          


Glu Thr Gly Thr Pro Val Thr Leu Arg Cys His Gln Thr Glu Asn His 
        35                  40                  45              


Arg Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Lys Asp Thr Asp Lys Gly Glu Val Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ser Lys Thr Glu Asp Phe Leu Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Ser Ser Gln Thr Ser Val Tyr Phe Cys Ala Ile 
            100                 105                 110         


Ser Asp Tyr Glu Gly Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val 
    130     


<210>  19
<211>  810
<212>  DNA
<213>  Homo sapiens

<400>  19
atggagacac tgctgaaggt gctgtctggc acactgctgt ggcagctgac ctgggtccga       60

tctcagcagc ctgttcagtc tcctcaggcc gtgatcctga gagaaggcga ggacgccgtg      120

atcaactgca gcagctctaa ggccctgtac agcgtgcact ggtacagaca gaagcacggc      180

gaggcccctg tgttcctgat gatcctgctg aaaggcggcg agcagaaggg ccacgagaag      240

atcagcgcca gcttcaacga gaagaagcag cagtccagcc tgtacctgac agccagccag      300

ctgagctaca gcggcaccta cttttgcggc acagccaata gcggcggcag caactacaag      360

ctgaccttcg gcaagggcac cctgctgacc gtgaatccca atatccagaa tccggagccc      420

gccgtatacc agctgaagga ccctagaagc caggacagca ccctgtgcct gttcaccgac      480

ttcgacagcc agatcaacgt gcccaagacc atggaaagcg gcaccttcat caccgacaag      540

acagtgctgg acatgaaggc catggacagc aagtccaacg gcgcaatcgc ctggtccaac      600

cagaccagct tcacatgcca ggacatcttc aaagagacaa acgccacata ccccagcagc      660

gacgtgccct gtgatgccac cctgacagag aagtccttcg agacagacat gaacctgaac      720

ttccagaatc tgtccgtgat gggcctgaga atcctgctgc tgaaggtggc cggcttcaat      780

ctgctgatga ccctgcggct gtggtccagc                                       810


<210>  20
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
            100                 105                 110         


Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu 
        115                 120                 125             


Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  21
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  21
atgggcacca gactgttctt ctacgtggcc ctgtgtctgc tgtggacagg ccatgtggat       60

gccggaatca cacagagccc cagacacaaa gtgaccgaga caggcacccc tgtgacactg      120

agatgtcacc agaccgagaa ccatcggtac atgtattggt acagacagga ccccggccac      180

ggcctgagac tgatccacta tagctacggc gtgaaggaca ccgacaaggg cgaagtgtct      240

gacggctaca gcgtgtccag aagcaagacc gaggacttcc tgctgaccct ggaaagcgcc      300

acaagcagcc agaccagcgt gtacttctgc gccatcagcg actacgaggg caccgaggcc      360

ttttttggcc aaggcacaag actgaccgtg gtggaagatc tccggaacgt gaccccccct      420

aaagtgaccc tgttcgaacc cagcaaggcc gagatcgcca acaagcagaa agccaccctc      480

gtgtgcctgg ccagaggctt cttccccgac catgtggaac tgtcttggtg ggtcaacggc      540

aaagaggtgc acagcggagt gtccaccgac cctcaggcct acaaagagag caactacagc      600

tactgcctga gcagcagact gcgggtgtcc gccaccttct ggcacaaccc ccggaaccac      660

ttcagatgcc aggtgcagtt tcacggcctg agcgaagagg acaagtggcc cgaaggctcc      720

cccaagcccg tgacccagaa tatctctgcc gaggcctggg gcagagccga ctgtggaatt      780

accagcgcca gctaccacca gggcgtgctg tctgccacca tcctgtacga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg tctggcctgg tgctgatggc catggtcaag      900

aagaagaaca gc                                                          912


<210>  22
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Thr 
1               5                   10                  15      


Gly His Val Asp Ala Gly Ile Thr Gln Ser Pro Arg His Lys Val Thr 
            20                  25                  30          


Glu Thr Gly Thr Pro Val Thr Leu Arg Cys His Gln Thr Glu Asn His 
        35                  40                  45              


Arg Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Lys Asp Thr Asp Lys Gly Glu Val Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ser Lys Thr Glu Asp Phe Leu Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Ser Ser Gln Thr Ser Val Tyr Phe Cys Ala Ile 
            100                 105                 110         


Ser Asp Tyr Glu Gly Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


<210>  23
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  23
atccagaatc cggagcccgc cgtataccag ctgaaggacc ctagaagcca ggacagcacc       60

ctgtgcctgt tcaccgactt cgacagccag atcaacgtgc ccaagaccat ggaaagcggc      120

accttcatca ccgacaagac agtgctggac atgaaggcca tggacagcaa gtccaacggc      180

gcaatcgcct ggtccaacca gaccagcttc acatgccagg acatcttcaa agagacaaac      240

gccacatacc ccagcagcga cgtgccctgt gatgccaccc tgacagagaa gtccttcgag      300

acagacatga acctgaactt ccagaatctg tccgtgatgg gcctgagaat cctgctgctg      360

aaggtggccg gcttcaatct gctgatgacc ctgcggctgt ggtccagc                   408


<210>  24
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  24

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
65                  70                  75                  80  


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
                85                  90                  95      


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
            100                 105                 110         


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
        115                 120                 125             


Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135     


<210>  25
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  25
gaagatctcc ggaacgtgac cccccctaaa gtgaccctgt tcgaacccag caaggccgag       60

atcgccaaca agcagaaagc caccctcgtg tgcctggcca gaggcttctt ccccgaccat      120

gtggaactgt cttggtgggt caacggcaaa gaggtgcaca gcggagtgtc caccgaccct      180

caggcctaca aagagagcaa ctacagctac tgcctgagca gcagactgcg ggtgtccgcc      240

accttctggc acaacccccg gaaccacttc agatgccagg tgcagtttca cggcctgagc      300

gaagaggaca agtggcccga aggctccccc aagcccgtga cccagaatat ctctgccgag      360

gcctggggca gagccgactg tggaattacc agcgccagct accaccaggg cgtgctgtct      420

gccaccatcc tgtacgagat cctgctgggc aaggccaccc tgtacgccgt gctggtgtct      480

ggcctggtgc tgatggccat ggtcaagaag aagaacagc                             519


<210>  26
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170             


<210>  27
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  28
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  29
<211>  140
<212>  PRT
<213>  Mus musculus

<400>  29

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Ser Asp Val Pro Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  30
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  31
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  31
accacactga gcaac                                                        15


<210>  32
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Thr Leu Ser Asn 
1               5   


<210>  33
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  33
ggcaccagca atcccaac                                                     18


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Thr Ser Asn Pro Asn 
1               5       


<210>  35
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  35
ctggtcaagt ccggcgaagt g                                                 21


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Val Lys Ser Gly Glu Val 
1               5           


<210>  37
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  37
agcgtcggca tcggc                                                        15


<210>  38
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Val Gly Ile Gly 
1               5   


<210>  39
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  39
tgtgctggcg ccctgcctag agccggcagc tatcaactga cattc                       45


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Ala Gly Ala Leu Pro Arg Ala Gly Ser Tyr Gln Leu Thr Phe 
1               5                   10                  15  


<210>  41
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  41
tgtgcttgga gcctcggagc cggctacacc gacacacagt atttt                       45


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Ala Trp Ser Leu Gly Ala Gly Tyr Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  43
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  43
atgctgctga tcacctccat gctggtgctg tggatgcagc tgagccaagt gaacggccag       60

caagtgatgc agatccctca gtaccagcac gtgcaagaag gcgaggactt caccacctac      120

tgcaacagca gcaccacact gagcaacatc cagtggtaca agcagcggcc tggcggacac      180

cctgtgtttc tgatccagct ggtcaagtcc ggcgaagtga agaagcagaa gcggctgacc      240

ttccagttcg gcgaggccaa gaagaacagc agcctgcaca tcaccgccac acagaccacc      300

gatgtgggca cctacttttg tgctggcgcc ctgcctagag ccggcagcta tcaactgaca      360

ttcggcaagg gcaccaagct gagcgtgatc cccaac                                396


<210>  44
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Ala Leu Pro 
            100                 105                 110         


Arg Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser 
        115                 120                 125             


Val Ile Pro Asn 
    130         


<210>  45
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  45
atgctgtgtt ctctgctggc tctgctgctg ggcacctttt ttggcgtcag aagccagacc       60

atccaccagt ggcctgctac actggtgcag cctgttggaa gccctctgag cctggaatgt      120

accgtggaag gcaccagcaa tcccaacctg tactggtaca gacaggccgc tggaagagga      180

ctgcagctgc tgttttacag cgtcggcatc ggccagatca gcagcgaggt tccacagaat      240

ctgagcgcca gcagacccca ggacagacag tttatcctga gcagcaagaa gctgctgctg      300

agcgacagcg gcttctacct gtgtgcttgg agcctcggag ccggctacac cgacacacag      360

tattttggcc ctggcaccag actgaccgtg ctg                                   393


<210>  46
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Gly Ala Gly Tyr Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  47
<211>  804
<212>  DNA
<213>  Homo sapiens

<400>  47
atgctgctga tcacctccat gctggtgctg tggatgcagc tgagccaagt gaacggccag       60

caagtgatgc agatccctca gtaccagcac gtgcaagaag gcgaggactt caccacctac      120

tgcaacagca gcaccacact gagcaacatc cagtggtaca agcagcggcc tggcggacac      180

cctgtgtttc tgatccagct ggtcaagtcc ggcgaagtga agaagcagaa gcggctgacc      240

ttccagttcg gcgaggccaa gaagaacagc agcctgcaca tcaccgccac acagaccacc      300

gatgtgggca cctacttttg tgctggcgcc ctgcctagag ccggcagcta tcaactgaca      360

ttcggcaagg gcaccaagct gagcgtgatc cccaacatcc agaatccgga gcccgccgta      420

taccagctga aggaccctag aagccaggac agcaccctgt gcctgttcac cgacttcgac      480

agccagatca acgtgcccaa gaccatggaa agcggcacct tcatcaccga caagacagtg      540

ctggacatga aggccatgga cagcaagtcc aacggcgcaa tcgcctggtc caaccagacc      600

agcttcacat gccaggacat cttcaaagag acaaacgcca cataccccag cagcgacgtg      660

ccctgtgatg ccaccctgac agagaagtcc ttcgagacag acatgaacct gaacttccag      720

aatctgtccg tgatgggcct gagaatcctg ctgctgaagg tggccggctt caatctgctg      780

atgaccctgc ggctgtggtc cagc                                             804


<210>  48
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Ala Leu Pro 
            100                 105                 110         


Arg Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  49
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  49
atgctgtgtt ctctgctggc tctgctgctg ggcacctttt ttggcgtcag aagccagacc       60

atccaccagt ggcctgctac actggtgcag cctgttggaa gccctctgag cctggaatgt      120

accgtggaag gcaccagcaa tcccaacctg tactggtaca gacaggccgc tggaagagga      180

ctgcagctgc tgttttacag cgtcggcatc ggccagatca gcagcgaggt tccacagaat      240

ctgagcgcca gcagacccca ggacagacag tttatcctga gcagcaagaa gctgctgctg      300

agcgacagcg gcttctacct gtgtgcttgg agcctcggag ccggctacac cgacacacag      360

tattttggcc ctggcaccag actgaccgtg ctggaagatc tccggaacgt gaccccccct      420

aaagtgaccc tgttcgaacc cagcaaggcc gagatcgcca acaagcagaa agccaccctc      480

gtgtgcctgg ccagaggctt cttccccgac catgtggaac tgtcttggtg ggtcaacggc      540

aaagaggtgc acagcggagt gtccaccgac cctcaggcct acaaagagag caactacagc      600

tactgcctga gcagcagact gcgggtgtcc gccaccttct ggcacaaccc ccggaaccac      660

ttcagatgcc aggtgcagtt tcacggcctg agcgaagagg acaagtggcc cgaaggctcc      720

cccaagcccg tgacccagaa tatctctgcc gaggcctggg gcagagccga ctgtggaatt      780

accagcgcca gctaccacca gggcgtgctg tctgccacca tcctgtacga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg tctggcctgg tgctgatggc catggtcaag      900

aagaagaaca gc                                                          912


<210>  50
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu 
            100                 105                 110         


Gly Ala Gly Tyr Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


<210>  51
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  52
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  mutated peptide

<400>  52

Tyr Tyr Ser Asp Ser Ile Phe Phe Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  mutated peptide

<400>  53

Leu Tyr Val Asp Thr Ile Gly Phe Leu 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  mutated peptide

<400>  54

Asp Tyr Val Asp Ser Leu Tyr Phe Cys 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  mutated peptide

<400>  55

Leu Tyr Tyr Asp His Leu Gly Phe Leu 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  mutated peptide

<400>  56

Asp Tyr Val Gly Thr Leu Phe Phe Leu 
1               5                   


