﻿               SEQUENCE LISTING

<110> Ablevia biotech GmbH

<120> Compound for increasing the efficacy of factor VIII replacement therapy

<130> R 78303

<160> 167

<150> EP 20197701.4
<151> 2020-09-23

<170> BiSSAP 1.3

<210> 1
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 1
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
1               5                   10                  15      
Met Pro 
        

<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 2
Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
1               5                   10                  15      



<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 3
Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys 
1               5                   10                  15      
Val Arg Phe Met 
            20  

<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 4
Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys 
1               5                   10                  

<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 5
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
1               5                   10                  15      



<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 6
Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 
1               5                   10                  15  

<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 7
Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro 
1               5                   10                  15      



<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 8
Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 
1               5                   10  

<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 9
Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro 
1               5                   10                  15  

<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 10
Gln Asp Gly His Gln Trp Thr Leu Phe Phe 
1               5                   10  

<210> 11
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 11
Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His 
1               5                   10                  15  

<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 12
Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg 
1               5                   10              

<210> 13
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 13
Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe 
1               5                   10              

<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 14
Met Gly Cys Asp Leu Asn Ser Cys Ser 
1               5                   

<210> 15
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 15
Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln 
1               5                   10                  15      
Asp Leu Tyr 
            

<210> 16
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 16
Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr 
1               5                   10                  15      
Lys Lys Val Arg Phe Met 
            20          

<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 17
Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 
1               5                   10  

<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 18
Gly Cys Asp Leu Asn Ser Cys 
1               5           

<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 19
Glu Leu Met Gly Cys Asp Leu 
1               5           

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 20
Cys Asp Leu Asn Ser Cys Ser 
1               5           

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 21
Met Glu Leu Met Gly Cys Asp 
1               5           

<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 22
Ser Thr Leu Arg Met Glu Leu Met Gly Cys 
1               5                   10  

<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 23
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro 
1               5                   10  

<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 24
Leu Asn Ser Cys Ser Met Pro 
1               5           

<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 25
Arg Met Glu Leu Met Gly Cys Asp Leu Asn 
1               5                   10  

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 26
Arg Met Glu Leu Met Gly Cys 
1               5           

<210> 27
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 27
Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 
1               5                   10              

<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 28
Leu Met Gly Cys Asp Leu Asn 
1               5           

<210> 29
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 29
Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro 
1               5                   10              

<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 30
Cys Glu Ala Gln Asp Leu Tyr 
1               5           

<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 31
Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
1               5                   10  

<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 32
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
1               5                   10              

<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 33
Met Glu Val Leu Gly Cys Glu 
1               5           

<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 34
Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr Gly 
1               5                   10              

<210> 35
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 35
Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr Gly Ser 
1               5                   10              

<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 36
Arg Met Glu Val Leu Gly Cys 
1               5           

<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 37
Glu Val Leu Gly Cys Glu Ala 
1               5           

<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 38
Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
1               5                   10  

<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 39
Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg 
1               5                   10              

<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 40
Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
1               5                   10              

<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 41
Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg 
1               5                   10  

<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 42
Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys 
1               5                   10              

<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 43
Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val 
1               5                   10  

<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 44
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val 
1               5                   10              

<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 45
Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
1               5                   10              

<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 46
Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys 
1               5                   10  

<210> 47
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 47
Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys 
1               5                   10              

<210> 48
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 48
Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
1               5                   10  

<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 49
Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys 
1               5                   10  

<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 50
Arg Lys Tyr Lys Lys Val Arg 
1               5           

<210> 51
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 51
Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 
1               5                   10              

<210> 52
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 52
Glu Val Gly Asp Thr Leu Leu Ile Ile Phe 
1               5                   10  

<210> 53
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 53
Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe 
1               5                   10              

<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 54
Asp Thr Leu Leu Ile Ile Phe 
1               5           

<210> 55
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 55
Val Gly Asp Thr Leu Leu Ile Ile Phe Lys 
1               5                   10  

<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 56
Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
1               5                   10  

<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 57
Thr Leu Leu Ile Ile Phe Lys 
1               5           

<210> 58
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 58
Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg 
1               5                   10              

<210> 59
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 59
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val 
1               5                   10              

<210> 60
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 60
Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
1               5                   10              

<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 61
Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg 
1               5                   10  

<210> 62
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 62
Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val 
1               5                   10  

<210> 63
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 63
Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
1               5                   10              

<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 64
Arg Lys Tyr Lys Lys Val Arg 
1               5           

<210> 65
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 65
Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys 
1               5                   10  

<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 66
Gly Pro Gln Arg Ile Gly Arg 
1               5           

<210> 67
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 67
Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys 
1               5                   10  

<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 68
Pro Gln Arg Ile Gly Arg Lys 
1               5           

<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 69
Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly 
1               5                   10              

<210> 70
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 70
Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg 
1               5                   10              

<210> 71
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 71
Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 
1               5                   10              

<210> 72
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 72
Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg 
1               5                   10  

<210> 73
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 73
Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly 
1               5                   10  

<210> 74
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 74
Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys 
1               5                   10  

<210> 75
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 75
Asp Gly Pro Thr Lys Ser Asp 
1               5           

<210> 76
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 76
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg 
1               5                   10              

<210> 77
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 77
Pro His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg 
1               5                   10              

<210> 78
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 78
Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro 
1               5                   10              

<210> 79
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 79
Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu 
1               5                   10              

<210> 80
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 80
Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg 
1               5                   10  

<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 81
Arg Pro Leu Tyr Ser Arg Arg 
1               5           

<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 82
Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg 
1               5                   10  

<210> 83
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 83
Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu 
1               5                   10  

<210> 84
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 84
Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro 
1               5                   10  

<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 85
Val Arg Pro Leu Tyr Ser Arg 
1               5           

<210> 86
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 86
Pro Arg Cys Leu Thr Arg 
1               5       

<210> 87
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 87
Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 
1               5                   10  

<210> 88
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 88
Gly Ser Gly Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 
1               5                   10              

<210> 89
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 89
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg 
1               5                   10              

<210> 90
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 90
His Leu Gln Gly Arg Ser Asn Ala Trp Arg 
1               5                   10  

<210> 91
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 91
Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp 
1               5                   10              

<210> 92
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 92
Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro 
1               5                   10              

<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 93
Leu His Leu Gln Gly Arg Ser Asn Ala Trp 
1               5                   10  

<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 94
Gly Arg Ser Asn Ala Trp Arg 
1               5           

<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 95
Gln Asp Gly His Gln Trp Thr Leu Phe Phe 
1               5                   10  

<210> 96
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 96
Gly His Gln Trp Thr Leu Phe 
1               5           

<210> 97
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 97
His Gln Trp Thr Leu Phe Phe 
1               5           

<210> 98
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 98
Leu Leu Thr Arg Tyr Leu Arg 
1               5           

<210> 99
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 99
Leu Thr Arg Tyr Leu Arg Ile 
1               5           

<210> 100
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 100
Pro Leu Leu Thr Arg Tyr Leu 
1               5           

<210> 101
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 101
Thr Arg Tyr Leu Arg Ile His 
1               5           

<210> 102
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 102
Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg 
1               5                   10              

<210> 103
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 103
Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg 
1               5                   10  

<210> 104
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 104
Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile 
1               5                   10  

<210> 105
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 105
Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg 
1               5                   10              

<210> 106
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 106
Val His Gln Ile Ala Leu Arg 
1               5           

<210> 107
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 107
His Gln Trp Thr Leu Phe Phe 
1               5           

<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 108
Gln Asp Gly His Gln Trp Thr Leu Phe Phe 
1               5                   10  

<210> 109
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 109
Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe 
1               5                   10              

<210> 110
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 110
Ser Gln Asp Gly His Gln Trp Thr Leu Phe 
1               5                   10  

<210> 111
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 111
Ser Gln Asp Gly His Gln Trp 
1               5           

<210> 112
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 112
Gly His Gln Trp Thr Leu Phe 
1               5           

<210> 113
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 113
Gly Cys Asp Leu Asn Ser Cys 
1               5           

<210> 114
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 114
Leu Arg Met Glu Leu Met Gly Cys Asp Leu 
1               5                   10  

<210> 115
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 115
Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 
1               5                   10  

<210> 116
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 116
Ser Thr Leu Arg Met Glu Leu Met Gly Cys 
1               5                   10  

<210> 117
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 117
Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
1               5                   10  

<210> 118
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 118
Glu Leu Met Gly Cys Asp Leu 
1               5           

<210> 119
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 119
Thr Leu Arg Met Glu Leu Met Gly Cys Asp 
1               5                   10  

<210> 120
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 120
Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys 
1               5                   10              

<210> 121
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 121
Arg Met Glu Val Leu Gly Cys 
1               5           

<210> 122
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 122
Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
1               5                   10  

<210> 123
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 123
Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
1               5                   10  

<210> 124
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 124
Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
1               5                   10              

<210> 125
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 125
Leu Gly Cys Glu Ala Gln Asp Leu Tyr Gly 
1               5                   10  

<210> 126
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 126
Glu Val Leu Gly Cys Glu Ala 
1               5           

<210> 127
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 127
Cys Gly Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly Cys Lys Gly 
1               5                   10                  15  

<210> 128
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 128
Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile 
1               5                   10                  15      
Pro Ser Glu Lys Gly Cys 
            20          

<210> 129
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 129
Asp His Thr Leu Tyr Thr Pro Tyr His Thr His Pro Gly 
1               5                   10              

<210> 130
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 130
Gly Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly 
1               5                   10      

<210> 131
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 131
Val Lys Lys Ile His Ile Pro Ser Glu Lys Gly 
1               5                   10      

<210> 132
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 132
Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu Lys 
1               5                   10          

<210> 133
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 133
Val Lys Lys Ile His Ile Pro Ser Glu Lys Gly Cys 
1               5                   10          

<210> 134
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 134
Ile Pro Asn Pro Leu Leu Gly Leu Asp Cys 
1               5                   10  

<210> 135
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 135
Ile Pro Asn Pro Leu Leu Gly Leu Asp Gly Gly Ser Gly Asp Tyr Lys 
1               5                   10                  15      
Asp Asp Asp Asp Lys Gly Lys 
            20              

<210> 136
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 136
Val Lys Lys Ile His Ile Pro Ser Glu Lys Gly Gly Ser Gly Asp Tyr 
1               5                   10                  15      
Lys Asp Asp Asp Asp Lys Gly Lys 
            20                  

<210> 137
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable (VH) region

<400> 137
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Thr Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Gln Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 138
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> light-chain variable (VL) region

<400> 138
Ser Val Val Met Thr Gln Thr Pro Lys Ser Leu Leu Ile Ser Ile Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gly Gln Asp Tyr Thr Ser Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 

<210> 139
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 139
Cys Ser Gly Arg Val Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val 
1               5                   10                  15      
Cys Asn Asn Gly Trp Ser Met Glu Ala 
            20                  25  

<210> 140
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 140
Gly Arg Val Glu Val Lys Val Gln Glu Glu Trp 
1               5                   10      

<210> 141
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 141
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10  

<210> 142
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 142
Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   

<210> 143
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 143
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu 
1               5                   10              

<210> 144
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 144
Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10              

<210> 145
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 145
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu Ala 
1               5                   10              

<210> 146
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 146
Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met 
1               5                   10              

<210> 147
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 147
Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   10              

<210> 148
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 148
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   10  

<210> 149
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 149
Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys Lys 
1               5                   10                  15      
His Asp Gly Trp Gly 
            20      

<210> 150
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 150
Glu Ser Ala Leu Trp 
1               5   

<210> 151
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 151
Glu Ser Ala Leu Trp Asp Cys 
1               5           

<210> 152
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 152
Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys 
1               5                   10  

<210> 153
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 153
Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
1               5                   10  

<210> 154
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 154
Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys 
1               5                   10              

<210> 155
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 155
Ala Leu Trp Asp Cys Lys His Asp Gly Trp 
1               5                   10  

<210> 156
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 156
Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
1               5                   10              

<210> 157
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 157
Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp 
1               5                   10  

<210> 158
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 158
Asn Glu Ser Ala Leu Trp Asp Cys Lys His Asp Gly Trp 
1               5                   10              

<210> 159
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 159
Glu Ser Ala Leu Trp Asp Cys Lys His Asp Gly Trp Gly 
1               5                   10              

<210> 160
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 160
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg Leu Val Asp Gly Glu 
1               5                   10                  15      
Asn Lys Cys Ser 
            20  

<210> 161
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 161
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg 
1               5                   10      

<210> 162
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 162
Ser Ser Leu Gly Gly 
1               5   

<210> 163
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 163
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu 
1               5                   10  

<210> 164
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 164
Ser Ser Leu Gly Gly Thr Asp Lys Glu 
1               5                   

<210> 165
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 165
Ser Ser Leu Gly Gly Thr Asp Lys 
1               5               

<210> 166
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 166
Ser Ser Leu Gly Gly Thr Asp 
1               5           

<210> 167
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 167
Ser Ser Leu Gly Gly Thr 
1               5       

