               SEQUENCE LISTING

<110> Ablevia biotech GmbH

<120> Compound for the sequestration of undesirable antibodies in a patient

<130> R 75869

<150> EP 20197706.3
<151> 23.09.2020

<160> 90

<170> BiSSAP 1.3

<210> 1
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable (VH) region

<400> 1
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              
Met Gly Tyr Ile Thr Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  
Lys Ser Gln Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 2
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable (VL) region

<400> 2
Ser Val Val Met Thr Gln Thr Pro Lys Ser Leu Leu Ile Ser Ile Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gly Gln Asp Tyr Thr Ser Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 

<210> 3
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 3
Cys Ser Gly Arg Val Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val 
1               5                   10                  15      
Cys Asn Asn Gly Trp Ser Met Glu Ala 
            20                  25  

<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 4
Gly Arg Val Glu Val Lys Val Gln Glu Glu Trp 
1               5                   10      

<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 5
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10  

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 6
Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   

<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 7
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu 
1               5                   10              

<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 8
Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10              

<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 9
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu Ala 
1               5                   10              

<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 10
Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met 
1               5                   10              

<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 11
Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   10              

<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 12
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   10  

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 13
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10  

<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 14
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu 
1               5                   10              

<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 15
Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10              

<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 16
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu Ala 
1               5                   10              

<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 17
Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met 
1               5                   10              

<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 18
Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   10              

<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 19
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
1               5                   10  

<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 20
Trp Gly Thr Val Cys Asn Asn Gly Trp Ser 
1               5                   10  

<210> 21
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 21
Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys Lys 
1               5                   10                  15      
His Asp Gly Trp Gly 
            20      

<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 22
Glu Ser Ala Leu Trp 
1               5   

<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 23
Glu Ser Ala Leu Trp Asp Cys 
1               5           

<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 24
Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys 
1               5                   10  

<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 25
Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
1               5                   10  

<210> 26
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 26
Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp Cys 
1               5                   10              

<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 27
Ala Leu Trp Asp Cys Lys His Asp Gly Trp 
1               5                   10  

<210> 28
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 28
Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
1               5                   10              

<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 29
Cys Arg Gly Asn Glu Ser Ala Leu Trp Asp 
1               5                   10  

<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 30
Asn Glu Ser Ala Leu Trp Asp Cys Lys His Asp Gly Trp 
1               5                   10              

<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 31
Glu Ser Ala Leu Trp Asp Cys Lys His Asp Gly Trp Gly 
1               5                   10              

<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 32
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg Leu Val Asp Gly Glu 
1               5                   10                  15      
Asn Lys Cys Ser 
            20  

<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 33
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg 
1               5                   10      

<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 34
Ser Ser Leu Gly Gly 
1               5   

<210> 35
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 35
Leu Gln Gln Gln Asn Thr 
1               5       

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 36
Thr Thr Thr Gly Gln Asn Asn Asn Ser 
1               5                   

<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 37
Gly Thr Ala Asn Thr Gln 
1               5       

<210> 38
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 38
Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile 
1               5                   10                  15      
Pro Ser Glu Lys 
            20  

<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 39
Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys 
1               5                   10  

<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 40
Val Lys Lys Ile His Ile Pro Ser Glu Lys 
1               5                   10  

<210> 41
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 41
Val Lys Lys Ile His Ile Pro Ser Glu Lys Gly 
1               5                   10      

<210> 42
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 42
Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly Cys Lys Gly Thr His 
1               5                   10                  15  

<210> 43
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 43
Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly Cys Lys Gly Ala His 
1               5                   10                  15  

<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 44
Lys Arg Pro Ser Cys Ile Gly Cys Lys 
1               5                   

<210> 45
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 45
Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      
Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile 
            20                  25          

<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 46
Thr Ala Met Glu Tyr Arg Trp Pro Phe Gly Asn Tyr Leu Cys Lys 
1               5                   10                  15  

<210> 47
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 47
Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn Ile Thr 
1               5                   10                  15      
Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            20                  25                  30  

<210> 48
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 48
Asp Val Leu Ile Gln Leu Gly Ile Ile Arg Asp Cys Arg 
1               5                   10              

<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 49
Ala Phe His Tyr Glu Ser Gln 
1               5           

<210> 50
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 50
Gly Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly 
1               5                   10      

<210> 51
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 51
Cys Gly Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly Cys Lys Gly 
1               5                   10                  15  

<210> 52
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 52
Leu Lys Trp Asn Pro Asp Asp Tyr Gly Gly Val Lys Lys Ile His Ile 
1               5                   10                  15      
Pro Ser Glu Lys Gly Cys 
            20          

<210> 53
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 53
Asp His Thr Leu Tyr Thr Pro Tyr His Thr His Pro Gly 
1               5                   10              

<210> 54
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 54
Gly Gly Val Lys Lys Ile His Ile Pro Ser Glu Lys 
1               5                   10          

<210> 55
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 55
Val Lys Lys Ile His Ile Pro Ser Glu Lys Gly Cys 
1               5                   10          

<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 56
Ile Pro Asn Pro Leu Leu Gly Leu Asp Cys 
1               5                   10  

<210> 57
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 57
Ile Pro Asn Pro Leu Leu Gly Leu Asp Gly Gly Ser Gly Asp Tyr Lys 
1               5                   10                  15      
Asp Asp Asp Asp Lys Gly Lys 
            20              

<210> 58
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 58
Val Lys Lys Ile His Ile Pro Ser Glu Lys Gly Gly Ser Gly Asp Tyr 
1               5                   10                  15      
Lys Asp Asp Asp Asp Lys Gly Lys 
            20                  

<210> 59
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 59
Cys Ser Gly Arg Val Glu Val Lys Val Gln Glu Glu Trp 
1               5                   10              

<210> 60
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 60
Asp Gly Glu Asn Lys Cys Ser Gly Arg Val Glu Val Lys Val Gln Glu 
1               5                   10                  15      
Glu Trp Gly Thr Val Cys Asn Asn Gly Trp Ser Met Glu Ala Val Ser 
            20                  25                  30          
Val Ile Cys Asn 
        35      

<210> 61
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 61
Arg Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu 
1               5                   10                  15      
Trp Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His 
            20                  25                  30          
Gln 
    

<210> 62
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 62
Val Thr Asn Ala Pro Gly Glu Met Lys Lys Glu Leu Arg 
1               5                   10              

<210> 63
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 63
Ala Ser Ala Val Thr Asn Ala Pro Gly Glu Met Lys Lys 
1               5                   10              

<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 64
Val Thr Asn Ala Pro Gly Glu Met Lys Lys 
1               5                   10  

<210> 65
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 65
Val Thr Asn Ala Pro Gly Glu 
1               5           

<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 66
Gly Ser Ala Ser Ala Val Thr Asn Ala Pro Gly Glu Met 
1               5                   10              

<210> 67
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 67
Ala Val Thr Asn Ala Pro Gly Glu Met Lys Lys Glu Leu 
1               5                   10              

<210> 68
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 68
Ser Ala Ser Ala Val Thr Asn Ala Pro Gly Glu Met Lys 
1               5                   10              

<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 69
Ser Gly Ser Ala Ser Ala Val Thr Asn Ala Pro Gly Glu 
1               5                   10              

<210> 70
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 70
Ala Val Thr Asn Ala Pro Gly Glu Met Lys 
1               5                   10  

<210> 71
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 71
Ser Ala Val Thr Asn Ala Pro Gly Glu Met 
1               5                   10  

<210> 72
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 72
Ala Ser Ala Val Thr Asn Ala Pro Gly Glu 
1               5                   10  

<210> 73
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 73
Ser Ala Val Thr Asn Ala Pro Gly Glu Met Lys Lys Glu 
1               5                   10              

<210> 74
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 74
Thr Asn Ala Pro Gly Glu Met Lys Lys Glu 
1               5                   10  

<210> 75
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 75
Val Thr Asn Ala Pro Gly Glu Met Lys Lys Glu Leu Arg Leu Ala Gly 
1               5                   10                  15      
Gly Glu Asn Asn Cys Ser 
            20          

<210> 76
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 76
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg Leu Val Asp Gly Glu 
1               5                   10                  15      
Asn Lys Cys Ser 
            20  

<210> 77
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 77
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg 
1               5                   10      

<210> 78
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 78
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu 
1               5                   10  

<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 79
Ser Ser Leu Gly Gly Thr Asp Lys Glu 
1               5                   

<210> 80
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 80
Ser Ser Leu Gly Gly Thr Asp Lys 
1               5               

<210> 81
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 81
Ser Ser Leu Gly Gly Thr Asp 
1               5           

<210> 82
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 82
Ser Ser Leu Gly Gly Thr 
1               5       

<210> 83
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 83
Ser Ser Leu Gly Gly 
1               5   

<210> 84
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 84
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu Arg 
1               5                   10      

<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 85
Ser Ser Leu Gly Gly Thr Asp Lys Glu Leu 
1               5                   10  

<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 86
Ser Ser Leu Gly Gly Thr Asp Lys Glu 
1               5                   

<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 87
Ser Ser Leu Gly Gly Thr Asp Lys 
1               5               

<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 88
Ser Ser Leu Gly Gly Thr Asp 
1               5           

<210> 89
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 89
Ser Ser Leu Gly Gly Thr 
1               5       

<210> 90
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 90
Ser Ser Leu Gly Gly 
1               5   

