﻿                         SEQUENCE LISTING

<110>  Shanghai Henlius Biotech, Inc. 
       Shanghai Henlius Biopharmaceutical Co., Ltd.
       Shanghai Henlius Biologics Co., Ltd.
       
<120>  ANTI-CD47 ANTIBODIES AND METHODS OF USE

<130>  P2021TC1834

<150>  PCT/CN2020/118320
<151>  2020-09-28 

<160>  104

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1 VH CDR1


<400>  1
Gly Tyr Tyr Trp Ser 
1               5   

<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1 VH CDR2


<400>  2
Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1 VH CDR3


<400>  3
Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1 VL CDR1


<400>  4
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1 VL CDR2


<400>  5
Gly Asn Asp Gln Arg Arg Ser 
1               5           

<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1 VL CDR3


<400>  6
Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 
1               5                   10      

<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1 VH


<400>  7
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1 VL


<400>  8
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  9
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(446)
<223>  Clone M1 HC


<400>  9
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     

<210>  10
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1 LC


<400>  10
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1#11 VH CDR1


<400>  11
Gly Tyr Tyr Trp Ser 
1               5   

<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1#11 VH CDR2


<400>  12
Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#11 VH CDR3


<400>  13
Phe His Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1#11 VL CDR1


<400>  14
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1#11VL CDR2


<400>  15
Gly Asn Asp Gln Arg Arg Arg 
1               5           

<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#11 VL CDR3


<400>  16
Ala Ala Trp Asp Asp Ser Leu Tyr Gly Arg Val 
1               5                   10      

<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1#11 VH


<400>  17
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe His Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1#11 VL


<400>  18
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Arg Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  19
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(445)
<223>  Clone M1#11 HC


<400>  19
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe His Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 

<210>  20
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#11 LC


<400>  20
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Arg Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1#25 VH CDR1


<400>  21
Gly Tyr Tyr Trp Ser 
1               5   

<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1#25 VH CDR2


<400>  22
Glu Ile Asn His Ser Gly Ser Val Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#25 VH CDR3


<400>  23
Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1#25 VL CDR1


<400>  24
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1#25 VL CDR2


<400>  25
Gly Asn Asp Gln Arg Arg Ser 
1               5           

<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#25 VL CDR3


<400>  26
Ala Ala Trp Asp Asp Ser Leu Ala Gly Arg Val 
1               5                   10      

<210>  27
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1#25 VH


<400>  27
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Val Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1#25 VL


<400>  28
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Ala Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  29
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(445)
<223>  Clone M1#25 HC


<400>  29
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Val Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 

<210>  30
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#25 LC


<400>  30
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Ala Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1#33 VH CDR1


<400>  31
Gly Tyr Tyr Trp Ser 
1               5   

<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1#33 VH CDR2


<400>  32
Glu Ile Asn His Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#33 VH CDR3


<400>  33
Phe Ile Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1#33 VL CDR1


<400>  34
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1#33 VL CDR2


<400>  35
Asp Asn Asp Gln Arg Arg Ser 
1               5           

<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#33 VL CDR3


<400>  36
Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 
1               5                   10      

<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1#33 VH


<400>  37
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Ile Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1#33 VL


<400>  38
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Asp Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  39
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(445)
<223>  Clone M1#33 HC


<400>  39
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Ile Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 

<210>  40
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#33 LC


<400>  40
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Asp Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1#46 VH CDR1


<400>  41
Gly Tyr Tyr Trp Ser 
1               5   

<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1#46 VH CDR2


<400>  42
Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#46  VH CDR3


<400>  43
Phe Ser Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1#46 VL CDR1


<400>  44
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1#46 VL CDR2


<400>  45
Gly Asn Asp Gln Arg Arg Ser 
1               5           

<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#46 VL CDR3


<400>  46
Ala Ala Trp Asp Asp Ser Leu Tyr Gly Arg Val 
1               5                   10      

<210>  47
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1#46 VH


<400>  47
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Ser Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  48
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1#46 VL


<400>  48
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  49
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(445)
<223>  Clone M1#46 HC


<400>  49
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Ser Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 

<210>  50
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#46 LC


<400>  50
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1#55 VH CDR1


<400>  51
Gly Tyr Tyr Trp Ser 
1               5   

<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1#55 VH CDR2


<400>  52
Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#55 VH CDR3


<400>  53
Phe Lys Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1#55 VL CDR1


<400>  54
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1#55 VL CDR2


<400>  55
Gly Asn Asp Gln Arg Arg Glu 
1               5           

<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#55 VL CDR3


<400>  56
Ala Ala Trp Asp Asp Ser Leu Tyr Gly Arg Val 
1               5                   10      

<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1#55 VH


<400>  57
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Lys Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  58
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1#55 VL


<400>  58
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Glu Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  59
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(445)
<223>  Clone M1#55 HC


<400>  59
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Lys Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 

<210>  60
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#55 LC


<400>  60
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Glu Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Clone M1#21 VH CDR1


<400>  61
Gly Tyr Tyr Trp Ser 
1               5   

<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  Clone M1#21 VH CDR2


<400>  62
Glu Ile Asn Gln Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      

<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#21 VH CDR3


<400>  63
Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val 
1               5                   10      

<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  Clone M1#21 VL CDR1


<400>  64
Ser Gly Ser Glu Ser Asn Ile Gly Ser His Lys Val Lys 
1               5                   10              

<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Clone M1#21 VL CDR2


<400>  65
Gly Asn Asp Gln Arg Phe Ser 
1               5           

<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  Clone M1#21 VL CDR3


<400>  66
Ala Ala Trp Asp Asp Ser Leu Tyr Gly Arg Val 
1               5                   10      

<210>  67
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(119)
<223>  Clone M1#21 VH


<400>  67
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Gln Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  68
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(116)
<223>  Clone M1#21 VL


<400>  68
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Phe Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro 
        115     

<210>  69
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(445)
<223>  Clone M1#21 HC


<400>  69
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Gln Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 

<210>  70
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#21 LC


<400>  70
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Phe Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Leu Thr Glu Cys Ser 
    210                 215                 

<210>  71
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(446)
<223>  Clone M1#21 HC-2


<400>  71
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Gln Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Thr Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     

<210>  72
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#21 LC-2


<400>  72
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Phe Ser Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 

<210>  73
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(446)
<223>  Clone M1#55 HC-2


<400>  73
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Phe Lys Gly Arg Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     

<210>  74
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CHAIN
<222>  (1)..(219)
<223>  Clone M1#55 LC-2


<400>  74
Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Thr 
1               5                   10                  15      
Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Glu Ser Asn Ile 
            20                  25                  30          
Gly Ser His Lys Val Lys Trp Tyr Gln Gln Phe Ala Gly Ala Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile His Gly Asn Asp Gln Arg Arg Glu Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  
Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                85                  90                  95      
Asp Ser Leu Tyr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         
Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             
Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 
Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 
Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     
Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         
Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             
Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 

<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  75Exemplary linker


<400>  75
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10          

<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(15)
<223>  76Exemplary linker


<400>  76
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  77Exemplary linker


<400>  77
Gly Gly Gly Ser Gly 
1               5   

<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  78Exemplary linker


<400>  78
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  

<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  79Exemplary linker


<400>  79
Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               

<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  80Exemplary linker


<400>  80
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          

<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(6)
<223>  81Exemplary linker


<400>  81
Gly Ser Gly Gly Ser Gly 
1               5       

<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  82Exemplary linker


<400>  82
Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   

<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  83Exemplary linker


<400>  83
Gly Ser Gly Ser Gly Ser Gly 
1               5           

<210>  84
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(21)
<223>  84Exemplary linker


<400>  84
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly 
            20      

<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  85Exemplary linker


<400>  85
Pro Ala Pro Ala Pro 
1               5   

<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(15)
<223>  86Exemplary linker


<400>  86
Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro 
1               5                   10                  15  

<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  87Exemplary linker


<400>  87
Ile Lys Arg Thr Val Ala Ala 
1               5           

<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  88Exemplary linker


<400>  88
Val Ser Ser Ala Ser Thr Lys 
1               5           

<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CONFLICT
<222>  (1)..(4)
<223>  89Exemplary linker


<400>  89
Ala Ser Thr Lys 
1               

<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  90Exemplary linker


<400>  90
Ala Ser Thr Lys Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10          

<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  91Exemplary linker


<400>  91
Ala Glu Ala Ala Ala Lys Ala 
1               5           

<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  92Exemplary linker


<400>  92
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          

<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  93Exemplary linker


<400>  93
Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser 
1               5                   10  

<210>  94
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  94Exemplary linker


<400>  94
Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser Gly 
1               5                   10                  15      
Arg Pro Gly Ser 
            20  

<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  95Exemplary linker


<400>  95
Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser 
1               5                   10  

<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  96Exemplary linker


<400>  96
Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser Gly 
1               5                   10                  15      
Arg Gly Gly Ser 
            20  

<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  97Exemplary linker


<400>  97
Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 
1               5                   10  

<210>  98
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  98Exemplary linker


<400>  98
Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly 
1               5                   10                  15      
Lys Pro Gly Ser 
            20  

<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  99Exemplary linker


<400>  99
Gly Glu Pro Gly Ser Gly Glu Pro Gly Ser 
1               5                   10  

<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  CONFLICT
<222>  (1)..(20)
<223>  100Exemplary linker


<400>  100
Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly 
1               5                   10                  15      
Glu Gly Gly Ser 
            20  

<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  101Exemplary linker


<400>  101
Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser 
1               5                   10  

<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  102Exemplary linker


<400>  102
Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser Gly 
1               5                   10                  15      
Asp Pro Gly Ser 
            20  

<210>  103
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  PEPTIDE
<222>  (1)..(312)
<223>  CD47 polypeptide


<400>  103
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      
Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          
Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              
Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  
Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  
Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      
Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         
Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             
Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 
Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 
Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     
Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         
Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             
Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 
Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 
Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     
Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         
Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             
Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 
Ala Val Glu Glu Pro Leu Asn Glu 
305                 310         

<210>  104
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  DOMAIN
<222>  (1)..(121)
<223>  CD47 N-terminal ECD


<400>  104
Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      
Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          
Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              
Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  
Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  
Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      
Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         
Tyr Arg Val Val Ser Trp Phe Ser Pro 
        115                 120     

