                         б

<110>  ҩҵ޹˾

       ں
 
<120>  ϸԵ

<130>  FE00481PCT

<150>  202011022544X 

<151>  2020/9/25    

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  2
<211>  21
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  3
<211>  717
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  3
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210>  4
<211>  66
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  4

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr 
65      


<210>  5
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  5
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgc                             339


<210>  6
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  7
<211>  126
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  7
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  8
<211>  42
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  66
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  9
gtgaaacaga ctttgaattt tgaccttctg aagttggcag gagacgttga gtccaaccct       60

gggccc                                                                  66


<210>  10
<211>  22
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  10

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  11
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  11
caggtgcagc tgcagcagcc cggcgccgag ctggtgcggc ccggcgccag cgtgaagctg       60

agctgcaagg ccagcggcta cagcttcacc acctactgga tgaactgggt gaagcagcgg      120

cccggccagg gcctggagtg gatcggcatg atccacccca gcgacagcga gacccggctg      180

aaccagaagt tcaaggacaa ggccaccctg accgtggaca agagcagcag caccgcctac      240

atgcagctga gcagccccac cagcgaggac agcgccgtgt actactgcgc ccggagcacc      300

atgatcgcca cccgggccat ggactactgg ggccagggca ccagcgtgac cgtgagcagc      360

ggtggaggcg gttcaggcgg aggtggttct ggcggtggcg gatcggacat cgtgatgacc      420

cagagccaga agagcatgag caccagcgtg ggcgaccggg tgagcatcac ctgcaaggcc      480

agccaggacg tgatcaccgg cgtggcctgg taccagcaga agcccggcca gagccccaag      540

ctgctgatct acagcgccag ctaccggtac accggcgtgc ccgaccggtt caccggcagc      600

ggcagcggca ccgacttcac cttcaccatc agcaacgtgc aggccgagga cctggccgtg      660

tactactgcc agcagcacta cagcaccccc ctgaccttcg gcgccggcac caagctggag      720

ctgaag                                                                 726


<210>  12
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys 
    130                 135                 140                 


Ser Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asp Val Ile Thr Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
        195                 200                 205             


Thr Ile Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys 
        


<210>  13
<211>  741
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  13
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc agctactgga tgaactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatgggccgg atcgacccct acgacagcga gacccactac      180

gcccagaagc tgcagggccg ggtgaccatg accaccgaca ccagcaccag caccgcctac      240

atggagctgc ggagcctgcg gagcgacgac accgccgtgt actactgcgc ccggggcggc      300

tacgacttcg acgtgggcac cctgtactgg ttcttcgacg tgtggggcca gggcaccacc      360

gtgaccgtga gcagcggtgg aggcggttca ggcggaggtg gttctggcgg tggcggatcg      420

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgggtgacc      480

atcacctgcc gggccagcga gaacatctac agctacctgg cctggtacca gcagaagccc      540

ggcaaggccc ccaagctgct gatctacaac gccaagaccc tggccgaggg cgtgcccagc      600

cggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      660

gaggacttcg ccacctacta ctgccagcac cactacggca ccccccggac cttcggcggc      720

ggcaccaagg tggagatcaa g                                                741


<210>  14
<211>  247
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr Leu Tyr Trp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys 
            180                 185                 190         


Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  15
<211>  732
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  15
gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttggc ggtaatgcca tgtcctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagca attagtggta atggtggtag tacattctac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagttcgt      300

ccattctggg gtactttcga ctactggggc caaggaaccc tggtcaccgt ctcgagtggt      360

ggaggcggtt caggcggagg tggttctggc ggtggcggat cggaaatcgt gttaacgcag      420

tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcttg cagggccagt      480

cagagtgtta gcagcagcta cttagcctgg taccagcaga aacctggcca ggctcccagg      540

ctcctcatct atggagcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      600

ggatccggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg      660

tattactgtc agcagtactt caacccacca gaatacacgt tcggccaggg gaccaaagtg      720

gaaatcaaac gt                                                          732


<210>  16
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Pro Phe Trp Gly Thr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Phe Asn Pro Pro Glu Tyr Thr Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  17
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  17
agagtctctc agctggtaca                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  18
gagtagcgcg agcacagcta                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  19
gcatgtcaga ttggtcacac                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  20
gagtacgtgc tgcatgtcta                                                   20


<210>  21
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  21

Thr Tyr Trp Met Asn 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  22

Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  23

Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  24

Lys Ala Ser Gln Asp Val Ile Thr Gly Val Ala 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  25

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  26

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  27
<211>  120
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  27

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  28

Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  29
<211>  4
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  29

Gly Gly Gly Ser 
1                     


<210>  30
<211>  243
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  30

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  31
<211>  489
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  31

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys 
    130                 135                 140                 


Ser Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asp Val Ile Thr Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
        195                 200                 205             


Thr Ile Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu 
                245                 250                 255     


Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly 
            260                 265                 270         


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly 
        275                 280                 285             


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
    290                 295                 300                 


Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys 
305                 310                 315                 320 


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
                325                 330                 335     


Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp 
    370                 375                 380                 


Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
385                 390                 395                 400 


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
                405                 410                 415     


Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
            420                 425                 430         


Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly 
        435                 440                 445             


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
    450                 455                 460                 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe 
465                 470                 475                 480 


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                485                 


<210>  32
<211>  207
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  32
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  33
<211>  69
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  33

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  34
<211>  12
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  34
ggtggtggat cc                                                           12


<210>  35
<211>  729
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  35
gatatcaaac tgcagcagtc aggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaaga cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca ctctcacagt ctcctcagtc      360

gaaggtggaa gtggaggttc tggtggaagt ggaggttcag gtggagtcga cgacattcag      420

ctgacccagt ctccagcaat catgtctgca tctccagggg agaaggtcac catgacctgc      480

agagccagtt caagtgtaag ttacatgaac tggtaccagc agaagtcagg cacctccccc      540

aaaagatgga tttatgacac atccaaagtg gcttctggag tcccttatcg cttcagtggc      600

agtgggtctg ggacctcata ctctctcaca atcagcagca tggaggctga agatgctgcc      660

acttattact gccaacagtg gagtagtaac ccgctcacgt tcggtgctgg gaccaagctg      720

gagctgaaa                                                              729


<210>  36
<211>  1467
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  36
caggtgcagc tgcagcagcc cggcgccgag ctggtgcggc ccggcgccag cgtgaagctg       60

agctgcaagg ccagcggcta cagcttcacc acctactgga tgaactgggt gaagcagcgg      120

cccggccagg gcctggagtg gatcggcatg atccacccca gcgacagcga gacccggctg      180

aaccagaagt tcaaggacaa ggccaccctg accgtggaca agagcagcag caccgcctac      240

atgcagctga gcagccccac cagcgaggac agcgccgtgt actactgcgc ccggagcacc      300

atgatcgcca cccgggccat ggactactgg ggccagggca ccagcgtgac cgtgagcagc      360

ggtggaggcg gttcaggcgg aggtggttct ggcggtggcg gatcggacat cgtgatgacc      420

cagagccaga agagcatgag caccagcgtg ggcgaccggg tgagcatcac ctgcaaggcc      480

agccaggacg tgatcaccgg cgtggcctgg taccagcaga agcccggcca gagccccaag      540

ctgctgatct acagcgccag ctaccggtac accggcgtgc ccgaccggtt caccggcagc      600

ggcagcggca ccgacttcac cttcaccatc agcaacgtgc aggccgagga cctggccgtg      660

tactactgcc agcagcacta cagcaccccc ctgaccttcg gcgccggcac caagctggag      720

ctgaagggtg gtggatccga tatcaaactg cagcagtcag gggctgaact ggcaagacct      780

ggggcctcag tgaagatgtc ctgcaagact tctggctaca cctttactag gtacacgatg      840

cactgggtaa aacagaggcc tggacagggt ctggaatgga ttggatacat taatcctagc      900

cgtggttata ctaattacaa tcagaagttc aaggacaagg ccacattgac tacagacaaa      960

tcctccagca cagcctacat gcaactgagc agcctgacat ctgaggactc tgcagtctat     1020

tactgtgcaa gatattatga tgatcattac tgccttgact actggggcca aggcaccact     1080

ctcacagtct cctcagtcga aggtggaagt ggaggttctg gtggaagtgg aggttcaggt     1140

ggagtcgacg acattcagct gacccagtct ccagcaatca tgtctgcatc tccaggggag     1200

aaggtcacca tgacctgcag agccagttca agtgtaagtt acatgaactg gtaccagcag     1260

aagtcaggca cctcccccaa aagatggatt tatgacacat ccaaagtggc ttctggagtc     1320

ccttatcgct tcagtggcag tgggtctggg acctcatact ctctcacaat cagcagcatg     1380

gaggctgaag atgctgccac ttattactgc caacagtgga gtagtaaccc gctcacgttc     1440

ggtgctggga ccaagctgga gctgaaa                                         1467


<210>  37
<211>  466
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  37

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Gln Lys 
    130                 135                 140                 


Ser Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asp Val Ile Thr Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
        195                 200                 205             


Thr Ile Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 


Pro Arg 
465     


<210>  38
<211>  319
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Phe Asp Val Gly Thr Leu Tyr Trp Phe Phe 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Ala Lys 
            180                 185                 190         


Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 


<210>  39
<211>  489
<212>  PRT
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Gly Gly Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Val Arg Pro Phe Trp Gly Thr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Tyr Phe Asn Pro Pro Glu Tyr Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  40
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  40
gaaccagcca tattgctctc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  41
gaccaatctg acatgctgca                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  42
ggtctgcaga gcaataagaa                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  43
gagctggtcg gttccgttgg                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  44
tttatagggt cagcagcctc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ˹˵˹ϳɵ 

<400>  45
gaaccgacca gctctttcac                                                   20


