                         б

<110>  йѧԺо
 
<120>  ǿ T ϸܵĻͷ

<130>  P2021TC1767

<150>  202011023678.3
<151>  2020-09-25

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  512
<212>  PRT
<213>  artificial sequence

<220>
<223>  M28Z CAR

<400>  1

Met Asp Tyr Lys Asp Asp Asp Asp Lys Ala Leu Pro Val Thr Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln 
            20                  25                  30          


Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser 
        35                  40                  45              


Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr 
    50                  55                  60                  


Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly 
65                  70                  75                  80  


Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
                85                  90                  95      


Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
            100                 105                 110         


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu 
                165                 170                 175     


Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu 
            180                 185                 190         


Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr 
        195                 200                 205             


Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr 
    210                 215                 220                 


Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe 
225                 230                 235                 240 


Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser 
                245                 250                 255     


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His 
            260                 265                 270         


Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu 
                325                 330                 335     


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            340                 345                 350         


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
        355                 360                 365             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
    370                 375                 380                 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  2
<211>  510
<212>  PRT
<213>  artificial sequence

<220>
<223>  MBBZ CAR

<400>  2

Met Asp Tyr Lys Asp Asp Asp Asp Lys Ala Leu Pro Val Thr Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln 
            20                  25                  30          


Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser 
        35                  40                  45              


Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr 
    50                  55                  60                  


Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly 
65                  70                  75                  80  


Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
                85                  90                  95      


Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
            100                 105                 110         


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu 
                165                 170                 175     


Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu 
            180                 185                 190         


Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr 
        195                 200                 205             


Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr 
    210                 215                 220                 


Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe 
225                 230                 235                 240 


Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser 
                245                 250                 255     


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His 
            260                 265                 270         


Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  3
<211>  498
<212>  PRT
<213>  artificial sequence

<220>
<223>  HER1 28Z CAR

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
        35                  40                  45              


Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Gln Gln 
    50                  55                  60                  


Thr Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Tyr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Gln Ile Thr Arg Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asn Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser 
        195                 200                 205             


Asn Phe Asn Glu Lys Phe Lys Thr Arg Val Thr Ile Thr Val Asp Glu 
    210                 215                 220                 


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Phe Tyr Phe Cys Ala Arg Gln Gly Leu Trp Phe Asp Ser Asp 
                245                 250                 255     


Gly Arg Gly Phe Asp Phe Trp Gly Gln Gly Ser Thr Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  4
<211>  496
<212>  PRT
<213>  artificial sequence

<220>
<223>  HER1 BBZ CAR

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
        35                  40                  45              


Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Gln Gln 
    50                  55                  60                  


Thr Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Phe Gln Tyr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Gln Ile Thr Arg Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
145                 150                 155                 160 


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asn Tyr Tyr Ile Tyr Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Ile Gly Gly Ile Asn Pro Thr Ser Gly Gly Ser 
        195                 200                 205             


Asn Phe Asn Glu Lys Phe Lys Thr Arg Val Thr Ile Thr Val Asp Glu 
    210                 215                 220                 


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Phe Tyr Phe Cys Ala Arg Gln Gly Leu Trp Phe Asp Ser Asp 
                245                 250                 255     


Gly Arg Gly Phe Asp Phe Trp Gly Gln Gly Ser Thr Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


