﻿                         序列表

<110>  博源润生医药（杭州）有限公司

<120>  靶向CPSG4的人源化嵌合抗原受体及表达该嵌抗原受体的免疫效应细胞及其应用

<130>  MTP19129

<160>  35

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  783
<212>  DNA
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的核酸

<400>  1
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgctct        60
agacaggttc agctggtgca gtctggcagc gagctgaaga aacctggcgc ctctgtgaag       120
gtgtcctgca aggctagcgg ctacacattc accgactaca gcatgcactg ggtccgaaag       180
gcccctggac agggacttga atggatgggc tggatcaaca ccgccacagg cgagcctacc       240
tacgccgatg gcttcacagg cagattcgtg atcagcctgg acaccagcgc cagaaccgtg       300
tacctgcaga tcagctctct gaaggccgag gataccgccg tgtacttctg cttcagctac       360
tacgactact ggggccaggg caccctggtc acagtttctt ctggtggtgg tggttctggt       420
ggtggtggtt ctggcggcgg cggctccggt ggtggtggat ccgacatcgt gctgacacag       480
agccctctga gcctgcctgt tacacctggc gagcctgcca gcatcagctg tagagccagc       540
cagaccatct acaagaacct gcactggtat ctgcagaagc ccggccagtc tcctcagctg       600
ctgattaagt acggcagcga cagcatctcc ggcgtgccag atagattcag cggctctggc       660
tctggcaccg actacaccct gaagatcagc agagtggaag ccgaggacgt gggcgtgtac       720
tactgtctgc aaggctacag caccccttgg acattcggcc agggcaccaa gctggaaatc       780
aag                                                                     783

<210>  2
<211>  261
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  2
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu 
            20                  25                  30          
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              
Thr Phe Thr Asp Tyr Ser Met His Trp Val Arg Lys Ala Pro Gly Gln 
    50                  55                  60                  
Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr 
65                  70                  75                  80  
Tyr Ala Asp Gly Phe Thr Gly Arg Phe Val Ile Ser Leu Asp Thr Ser 
                85                  90                  95      
Ala Arg Thr Val Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr 
            100                 105                 110         
Ala Val Tyr Phe Cys Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
145                 150                 155                 160 
Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser 
                165                 170                 175     
Cys Arg Ala Ser Gln Thr Ile Tyr Lys Asn Leu His Trp Tyr Leu Gln 
            180                 185                 190         
Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Lys Tyr Gly Ser Asp Ser 
        195                 200                 205             
Ile Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 
Tyr Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
225                 230                 235                 240 
Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr 
                245                 250                 255     
Lys Leu Glu Ile Lys 
            260     

<210>  3
<211>  339
<212>  DNA
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的核酸

<400>  3
caggttcagc tggtgcagtc tggcagcgag ctgaagaaac ctggcgcctc tgtgaaggtg        60
tcctgcaagg ctagcggcta cacattcacc gactacagca tgcactgggt ccgaaaggcc       120
cctggacagg gacttgaatg gatgggctgg atcaacaccg ccacaggcga gcctacctac       180
gccgatggct tcacaggcag attcgtgatc agcctggaca ccagcgccag aaccgtgtac       240
ctgcagatca gctctctgaa ggccgaggat accgccgtgt acttctgctt cagctactac       300
gactactggg gccagggcac cctggtcaca gtttcttct                              339

<210>  4
<211>  113
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  4
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Lys Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Gly Phe 
    50                  55                  60                  
Thr Gly Arg Phe Val Ile Ser Leu Asp Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210>  5
<211>  8
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  5
Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               

<210>  6
<211>  8
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  6
Ile Asn Thr Ala Thr Gly Glu Pro 
1               5               

<210>  7
<211>  6
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  7
Phe Ser Tyr Tyr Asp Tyr 
1               5       

<210>  8
<211>  321
<212>  DNA
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的核酸

<400>  8
gacatcgtgc tgacacagag ccctctgagc ctgcctgtta cacctggcga gcctgccagc        60
atcagctgta gagccagcca gaccatctac aagaacctgc actggtatct gcagaagccc       120
ggccagtctc ctcagctgct gattaagtac ggcagcgaca gcatctccgg cgtgccagat       180
agattcagcg gctctggctc tggcaccgac tacaccctga agatcagcag agtggaagcc       240
gaggacgtgg gcgtgtacta ctgtctgcaa ggctacagca ccccttggac attcggccag       300
ggcaccaagc tggaaatcaa g                                                 321

<210>  9
<211>  107
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  9
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln Thr Ile Tyr Lys Asn 
            20                  25                  30          
Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Lys Tyr Gly Ser Asp Ser Ile Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  10
<211>  11
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  10
Arg Ala Ser Gln Thr Ile Tyr Lys Asn Leu His 
1               5                   10      

<210>  11
<211>  7
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  11
Tyr Gly Ser Asp Ser Ile Ser 
1               5           

<210>  12
<211>  9
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  12
Leu Gln Gly Tyr Ser Thr Pro Trp Thr 
1               5                   

<210>  13
<211>  783
<212>  DNA
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的核酸

<400>  13
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgctct        60
agagacatcg tgctgacaca gagccctctg agcctgcctg ttacacctgg cgagcctgcc       120
agcatcagct gtagagccag ccagaccatc tacaagaacc tgcactggta tctgcagaag       180
cccggccagt ctcctcagct gctgattaag tacggcagcg acagcatctc cggcgtgcca       240
gatagattca gcggctctgg ctctggcacc gactacaccc tgaagatcag cagagtggaa       300
gccgaggacg tgggcgtgta ctactgtctg caaggctaca gcaccccttg gacattcggc       360
cagggcacca agctggaaat caagggtggt ggtggttctg gtggtggtgg ttctggcggc       420
ggcggctccg gtggtggtgg atcccaggtt cagctggtgc agtctggcag cgagctgaag       480
aaacctggcg cctctgtgaa ggtgtcctgc aaggctagcg gctacacatt caccgactac       540
agcatgcact gggtccgaaa ggcccctgga cagggacttg aatggatggg ctggatcaac       600
accgccacag gcgagcctac ctacgccgat ggcttcacag gcagattcgt gatcagcctg       660
gacaccagcg ccagaaccgt gtacctgcag atcagctctc tgaaggccga ggataccgcc       720
gtgtacttct gcttcagcta ctacgactac tggggccagg gcaccctggt cacagtttct       780
tct                                                                     783

<210>  14
<211>  261
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  14
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu 
            20                  25                  30          
Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Thr Ile Tyr Lys Asn Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  
Pro Gln Leu Leu Ile Lys Tyr Gly Ser Asp Ser Ile Ser Gly Val Pro 
65                  70                  75                  80  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Lys Ile 
                85                  90                  95      
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Gly 
            100                 105                 110         
Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys 
145                 150                 155                 160 
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     
Phe Thr Asp Tyr Ser Met His Trp Val Arg Lys Ala Pro Gly Gln Gly 
            180                 185                 190         
Leu Glu Trp Met Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr 
        195                 200                 205             
Ala Asp Gly Phe Thr Gly Arg Phe Val Ile Ser Leu Asp Thr Ser Ala 
    210                 215                 220                 
Arg Thr Val Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala 
225                 230                 235                 240 
Val Tyr Phe Cys Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     
Val Thr Val Ser Ser 
            260     

<210>  15
<211>  20
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  15
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210>  16
<211>  25
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  16
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210>  17
<211>  17
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  17
Met His Trp Val Arg Lys Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      
Trp 
    

<210>  18
<211>  38
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  18
Thr Tyr Ala Asp Gly Phe Thr Gly Arg Phe Val Ile Ser Leu Asp Thr 
1               5                   10                  15      
Ser Ala Arg Thr Val Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
            20                  25                  30          
Thr Ala Val Tyr Phe Cys 
        35              

<210>  19
<211>  11
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  19
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210>  20
<211>  23
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  20
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys 
            20              

<210>  21
<211>  15
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  21
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Lys 
1               5                   10                  15  

<210>  22
<211>  32
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  22
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          

<210>  23
<211>  10
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  23
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210>  24
<211>  135
<212>  DNA
<213>  Homo sapiens

<220>
<223>  合成的核酸

<400>  24
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg        60
tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg       120
gacttcgcct gtgat                                                        135

<210>  25
<211>  45
<212>  PRT
<213>  Homo sapiens

<220>
<223>  合成的多肽

<400>  25
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  26
<211>  72
<212>  DNA
<213>  Homo sapiens

<220>
<223>  合成的核酸

<400>  26
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc        60
accctttact gc                                                            72

<210>  27
<211>  24
<212>  PRT
<213>  Homo sapiens

<220>
<223>  合成的多肽

<400>  27
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  

<210>  28
<211>  123
<212>  DNA
<213>  Homo sapiens

<220>
<223>  合成的核酸

<400>  28
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc        60
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc       120
tcc                                                                     123

<210>  29
<211>  41
<212>  PRT
<213>  Homo sapiens

<220>
<223>  合成的多肽

<400>  29
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      

<210>  30
<211>  126
<212>  DNA
<213>  Homo sapiens

<220>
<223>  合成的核酸

<400>  30
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa        60
actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt       120
gaactg                                                                  126

<210>  31
<211>  42
<212>  PRT
<213>  Homo sapiens

<220>
<223>  合成的多肽

<400>  31
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210>  32
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  合成的核酸

<400>  32
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc        60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc       120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat       180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc       240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc       300
tacgacgccc ttcacatgca ggccctgccc cctcgc                                 336

<210>  33
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  合成的多肽

<400>  33
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210>  34
<211>  1479
<212>  DNA
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的核酸

<400>  34
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgctct        60
agagacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc       120
accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa       180
ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca       240
tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag       300
caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga       360
ggggggacca agctggagct gaaacgtggt ggtggtggtt ctggtggtgg tggttctggc       420
ggcggcggct ccggtggtgg tggatccgag gtgcagctgc agcagtctgg acctggcctg       480
gtggcgccct cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac       540
tatggtgtaa gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata       600
tggggtagtg aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag       660
gacaactcca agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc       720
atttactact gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc       780
caagggacct cagtcaccgt ctcctcaacg cgtaccacga cgccagcgcc gcgaccacca       840
acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca       900
gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg       960
gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc      1020
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc      1080
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      1140
tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag      1200
ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      1260
ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      1320
aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      1380
cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      1440
acctacgacg cccttcacat gcaggccctg ccccctcgc                             1479

<210>  35
<211>  493
<212>  PRT
<213>  人工合成(Artificial Sequence)

<220>
<223>  合成的多肽

<400>  35
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
145                 150                 155                 160 
Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
                165                 170                 175     
Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
            180                 185                 190         
Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
        195                 200                 205             
Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
    210                 215                 220                 
Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
225                 230                 235                 240 
Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Arg Thr 
            260                 265                 270         
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     
Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         
Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             
Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    370                 375                 380                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             

