﻿                         序列表

<110>  南京圣和药业股份有限公司

<120>  抗TIGIT抗体及双抗体和它们的应用

<150>  CN 202011000787.3
<151>  2020-09-22

<160>  111

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  1
Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  

<210>  2
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  2
Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys Ser 
1               5                   10                  15      

<210>  3
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  3
Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr 
1               5                   10  

<210>  4
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  4
Gly Tyr Ser Ile Thr Ser Asp Tyr Trp Asn 
1               5                   10  

<210>  5
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  5
Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Arg 
1               5                   10                  15      

<210>  6
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  6
Tyr Arg Asp Trp Pro Gly Tyr Phe Asp Val 
1               5                   10  

<210>  7
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  7
Gly Tyr Thr Phe Thr Arg Asn Thr Met His 
1               5                   10  

<210>  8
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  8
Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210>  9
<211>  5
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3


<400>  9
Trp Pro Met Asp Tyr 
1               5   

<210>  10
<211>  10
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  10
Gly Tyr Ser Phe Thr Ser Asn Trp Met Asn 
1               5                   10  

<210>  11
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  11
Met Ile His Leu Tyr Asp Ser Glu Thr Lys Leu Asn Pro Asn Phe Gln 
1               5                   10                  15      
Asp 
    

<210>  12
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  12
Ser Ala Gly Asn Tyr Arg Phe Ala Tyr 
1               5                   

<210>  13
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  13
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Ser Leu 
1               5                   10                  15      
Ala 
    

<210>  14
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2


<400>  14
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210>  15
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  15
Gln Gln Tyr Tyr Gly Tyr Pro Leu Thr 
1               5                   

<210>  16
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  16
Arg Ala Ser Lys Ser Ile Arg Lys Phe Leu Ala 
1               5                   10      

<210>  17
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  17
Ser Gly Ser Thr Leu Gln Ser 
1               5           

<210>  18
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  18
Gln His Tyr Asn Glu Tyr Pro Phe Thr 
1               5                   

<210>  19
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  19
Lys Ser Ser Gln Ser Leu Ser Trp Ser Glu Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      
Ser 
    

<210>  20
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  20
Gly Ala Ser Ile Arg Glu Ser 
1               5           

<210>  21
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  21
Gln His Asn His Gly Ser Phe Leu Pro Tyr Thr 
1               5                   10      

<210>  22
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  22
Lys Ala Ser Gln Ser Val Ser Asn Glu Val Ala 
1               5                   10      

<210>  23
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  23
Ser Ala Ser Ser Arg Tyr Thr 
1               5           

<210>  24
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  24
Gln Gln His Tyr Ser Ser Pro Leu Thr 
1               5                   

<210>  25
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  25
Thr Tyr Gly Leu Gly Val Gly 
1               5           

<210>  26
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  26
Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      

<210>  27
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)


<220>
<223>  HCDR3

<400>  27
Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile Leu Asp Val 
1               5                   10                  15      

<210>  28
<211>  5
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR1

<400>  28
Asp His Trp Met Ser 
1               5   

<210>  29
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR2

<400>  29
Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu Lys 
1               5                   10                  15      
Asn 
    

<210>  30
<211>  17
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  HCDR3

<400>  30
Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala Ser Val 
1               5                   10                  15      
Tyr 
    

<210>  31
<211>  16
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  31
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Ser 
1               5                   10                  15      

<210>  32
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  32
Gln Ile Ser Asn Leu Ala Ser 
1               5           

<210>  33
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  33
Met Gln Phe Leu Glu Val Pro Tyr Thr 
1               5                   

<210>  34
<211>  11
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR1

<400>  34
Arg Thr Ser Gln Asp Ile Gly Asn Ser Leu Arg 
1               5                   10      

<210>  35
<211>  7
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR2

<400>  35
Gly Ala Thr Asn Leu Ala Asn 
1               5           

<210>  36
<211>  9
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  LCDR3

<400>  36
Leu Gln His Asn Glu Tyr Pro Leu Thr 
1               5                   

<210>  37
<211>  118
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Heavy chain variable region

<400>  37
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser 
        115             

<210>  38
<211>  118
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Heavy chain variable region

<400>  38
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ala Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Arg Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Asn Tyr Tyr Leu 
65                  70                  75                  80  
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Arg Asp Trp Pro Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210>  39
<211>  114
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Heavy chain variable region

<400>  39
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  40
<211>  118
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Heavy chain variable region

<400>  40
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      
Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Asn 
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile His Leu Tyr Asp Ser Glu Thr Lys Leu Asn Pro Asn Phe 
    50                  55                  60                  
Gln Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Ala Gly Asn Tyr Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ala 
        115             

<210>  41
<211>  113
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Light chain variable region

<400>  41
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210>  42
<211>  107
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Light chain variable region

<400>  42
Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      
Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Arg Lys Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Glu Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  43
<211>  115
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Light chain variable region

<400>  43
Asp Ile Val Met Thr Gln Phe Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Ser Trp Ser 
            20                  25                  30          
Glu Asn Gln Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Trp Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Asn Val His Ala Glu Asp Leu Gly Val Tyr Phe Cys Gln His 
                85                  90                  95      
Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         
Glu Ile Lys 
        115 

<210>  44
<211>  107
<212>  PRT
<213>  鼠源(Mus musculus)

<220>
<223>  Light chain variable region

<400>  44
Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Pro Val Thr Ala Glu 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Glu 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly 
    50                  55                  60                  
Gly Gly Ser Ala Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Val 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr Ser Ser Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210>  45
<211>  99
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region 

<400>  45
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg 
            

<210>  46
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg 
        

<210>  47
<211>  101
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  47
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Thr Pro 
            100     

<210>  48
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  49
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  49
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  50
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  50
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  51
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  51
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  52
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  52
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Leu Thr Val Ser Ser 
        115             

<210>  53
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  53
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210>  54
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  54
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210>  55
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  55
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210>  56
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  56
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210>  57
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  57
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  58
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)


<220>
<223>  Heavy chain variable region

<400>  58
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  59
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)


<220>
<223>  Heavy chain variable region

<400>  59
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Ile Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  60
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)


<220>
<223>  Heavy chain variable region

<400>  60
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Ile Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  61
<211>  114
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Ile Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser 
        

<210>  62
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  62
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Ser Trp Ser 
            20                  25                  30          
Glu Asn Gln Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
            100                 105                 110         
Glu Ile Lys 
        115 

<210>  63
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  63
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Ser Trp Ser 
            20                  25                  30          
Glu Asn Gln Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
            100                 105                 110         
Glu Ile Lys 
        115 

<210>  64
<211>  115
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  64
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Ser Trp Ser 
            20                  25                  30          
Glu Asn Gln Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
            100                 105                 110         
Glu Ile Lys 
        115 

<210>  65
<211>  378
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  TIGIT-hIgG1-Fc fusion protein

<400>  65
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Ile Glu Gly 
    130                 135                 140                 
Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        275                 280                 285             
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375             

<210>  66
<211>  377
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  TIGIT-mIgG1-Fc fusion protein

<400>  66
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Ser Pro 
    130                 135                 140                 
Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
145                 150                 155                 160 
Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                165                 170                 175     
Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            180                 185                 190         
Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        195                 200                 205             
Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    210                 215                 220                 
Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
225                 230                 235                 240 
Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                245                 250                 255     
Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            260                 265                 270         
Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        275                 280                 285             
Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    290                 295                 300                 
Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
305                 310                 315                 320 
Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                325                 330                 335     
Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            340                 345                 350         
Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        355                 360                 365             
Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    370                 375         

<210>  67
<211>  150
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  TIGIT-his fusion protein

<400>  67
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Ser Gly Ser 
    130                 135                 140                 
His His His His His His 
145                 150 

<210>  68
<211>  580
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD155-hIgG1-Fc fusion protein

<400>  68
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     
His Ser Gly Met Ser Arg Asn Ile Glu Gly Arg Met Asp Pro Lys Ser 
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                565                 570                 575     
Ser Pro Gly Lys 
            580 

<210>  69
<211>  579
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD155-mIgG1-Fc fusion protein

<400>  69
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     
His Ser Gly Met Ser Arg Asn Phe Ser Pro Glu Pro Arg Gly Pro Thr 
            340                 345                 350         
Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
        355                 360                 365             
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
    370                 375                 380                 
Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
385                 390                 395                 400 
Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                405                 410                 415     
His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
            420                 425                 430         
Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        435                 440                 445             
Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
    450                 455                 460                 
Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
465                 470                 475                 480 
Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
                485                 490                 495     
Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
            500                 505                 510         
Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
        515                 520                 525             
Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
    530                 535                 540                 
Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
545                 550                 555                 560 
His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
                565                 570                 575     
Pro Gly Lys 
            

<210>  70
<211>  349
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD155-his fusion protein

<400>  70
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     
His Ser Gly Met Ser Arg Asn His His His His His His 
            340                 345                 

<210>  71
<211>  130
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region of 22G2

<400>  71
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          
Ile Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Tyr Tyr Val Ser Gly Asn Tyr Tyr Asn Val Asp Tyr 
            100                 105                 110         
Tyr Phe Phe Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             
Ser Ser 
    130 

<210>  72
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region of 22G2

<400>  72
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      
Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 

<210>  73
<211>  244
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  TIGIT protein

<400>  73
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 
Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 
Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     
Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         
Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             
Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 
Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 
Thr Glu Thr Gly 
                

<210>  74
<211>  417
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD155 protein

<400>  74
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     
His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 
Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 
Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     
Arg 
    

<210>  75
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region
 
<400>  75
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Arg Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Leu Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  
Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 125     

<210>  76
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  76
Glu Val Gln Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Val Gly Ser Gly Phe Ser Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Thr Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Thr Asn Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  77
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  77
Asp Ile Met Met Thr Gln Ser Pro Leu Ser Val Ala Val Thr Pro Gly 
1               5                   10                  15      
Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Arg Pro Glu Lys Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Phe Gln Ile Ser Asn Leu Ala Ser Gly Val Ser 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile 
65                  70                  75                  80  
Ser Lys Val Glu Thr Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      
Leu Glu Val Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         

<210>  78
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Pro Thr Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Arg Leu Met Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ala Gly Ser Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ser 
65                  70                  75                  80  
Glu Asp Met Ala Met Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  79
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  79
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     

<210>  80
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)


<220>
<223>  Heavy chain variable region

<400>  80
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Ala 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     

<210>  81
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  81
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Arg Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Ala 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     

<210>  82
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  82
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Ala 
65                  70                  75                  80  
Val Leu Thr Ile Thr Asn Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     

<210>  83
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  83
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Arg Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Ala 
65                  70                  75                  80  
Val Leu Thr Ile Thr Asn Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     

<210>  84
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  84
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Ile Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      
Leu Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  85
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  85
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Phe Gln Ile Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      
Leu Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  86
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  86
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Glu Lys Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Phe Gln Ile Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      
Leu Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  87
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  87
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Glu Lys Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Phe Gln Ile Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      
Leu Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  88
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  88
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  89
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  89
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  90
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  90
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Met Glu Trp Ile 
        35                  40                  45              
Ala Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  91
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  91
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Met Glu Trp Ile 
        35                  40                  45              
Ala Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  92
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region

<400>  92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  93
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  93
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  94
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  94
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  95
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  95
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  96
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  96
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Met Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  97
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region

<400>  97
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Met Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Met Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  98
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region of SHS006-T-Hu17-31

<400>  98
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Arg Thr Tyr 
            20                  25                  30          
Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Glu Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Ala 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Ala Arg Pro His Tyr Tyr Trp Asp Gly Arg Tyr Ile 
            100                 105                 110         
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     

<210>  99
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Heavy chain variable region of SHS006-T-Hu23-53

<400>  99
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Thr Met Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala 
            100                 105                 110         
Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     

<210>  100
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)


<220>
<223>  Light chain variable region of SHS006-T-Hu17-31

<400>  100
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Ile Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Phe 
                85                  90                  95      
Leu Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  101
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Light chain variable region of SHS006-T-Hu23-53

<400>  101
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  102
<211>  707
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  ScFab-T2353-Knob-PHR protein

<400>  102
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Gly Asn Ser 
            20                  25                  30          
Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                245                 250                 255     
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            260                 265                 270         
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His Trp Met 
        275                 280                 285             
Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Met Glu Trp Ile Gly Asn 
    290                 295                 300                 
Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala Pro Ser Leu Lys Asn 
305                 310                 315                 320 
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
                325                 330                 335     
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Arg 
            340                 345                 350         
Gly His Phe Arg Ile Thr Met Ala Ser Met Gly Ala Ser Ala Ser Val 
        355                 360                 365             
Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
385                 390                 395                 400 
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        435                 440                 445             
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    450                 455                 460                 
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
465                 470                 475                 480 
Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                485                 490                 495     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            500                 505                 510         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        515                 520                 525             
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    530                 535                 540                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
545                 550                 555                 560 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                565                 570                 575     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            580                 585                 590         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        595                 600                 605             
Tyr Thr Leu Pro Pro Cys Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    610                 615                 620                 
Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
625                 630                 635                 640 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                645                 650                 655     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            660                 665                 670         
Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        675                 680                 685             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    690                 695                 700                 
Leu Gly Lys 
705         

<210>  103
<211>  705
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  HuPL721-scfab-hole-PHR protein

<400>  103
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
    210                 215                 220                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
            260                 265                 270         
Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser 
        275                 280                 285             
Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Cys 
    290                 295                 300                 
Leu Glu Tyr Ile Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn 
305                 310                 315                 320 
Leu Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                325                 330                 335     
Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            340                 345                 350         
Tyr Tyr Cys Ala Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
465                 470                 475                 480 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                485                 490                 495     
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        515                 520                 525             
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            580                 585                 590         
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
        595                 600                 605             
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
    610                 615                 620                 
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys 
            660                 665                 670         
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    690                 695                 700                 
Lys 
705 

<210>  104
<211>  708
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  PL721-T2353-scFv-HC-PHR protein

<400>  104
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly 
        435                 440                 445             
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    450                 455                 460                 
Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 
Gly Phe Thr Phe Ser Asp His Trp Met Ser Trp Val Arg Gln Ala Pro 
                485                 490                 495     
Gly Lys Cys Met Glu Trp Ile Gly Asn Ile Gln Tyr Asp Gly Ser Tyr 
            500                 505                 510         
Thr Asn Tyr Ala Pro Ser Leu Lys Asn Arg Phe Thr Ile Ser Arg Asp 
        515                 520                 525             
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    530                 535                 540                 
Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Gly His Phe Arg Ile Thr Met 
545                 550                 555                 560 
Ala Ser Met Gly Ala Ser Ala Ser Val Tyr Trp Gly Gln Gly Thr Met 
                565                 570                 575     
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
        595                 600                 605             
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    610                 615                 620                 
Arg Thr Ser Gln Asp Ile Gly Asn Ser Leu Arg Trp Phe Gln Gln Lys 
625                 630                 635                 640 
Pro Gly Lys Ala Pro Lys Leu Leu Ile His Gly Ala Thr Asn Leu Ala 
                645                 650                 655     
Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            660                 665                 670         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        675                 680                 685             
Cys Leu Gln His Asn Glu Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
    690                 695                 700                 
Leu Glu Ile Lys 
705             

<210>  105
<211>  220
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  HuPL721-VL1-PHR protein

<400>  105
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210>  106
<211>  705
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  HuPL743-scfab-hole-PHR protein

<400>  106
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
    210                 215                 220                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     
Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
            260                 265                 270         
Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser 
        275                 280                 285             
Ile Thr Ser Gly Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Cys 
    290                 295                 300                 
Leu Glu Tyr Met Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn 
305                 310                 315                 320 
Leu Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                325                 330                 335     
Gln Tyr Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            340                 345                 350         
Tyr Tyr Cys Ala Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
465                 470                 475                 480 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                485                 490                 495     
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        515                 520                 525             
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            580                 585                 590         
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
        595                 600                 605             
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
    610                 615                 620                 
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys 
            660                 665                 670         
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    690                 695                 700                 
Lys 
705 

<210>  107
<211>  708
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  PL743-T2353-scFv-HC-PHR protein

<400>  107
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Leu Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Tyr Ile Leu Trp Leu Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly 
        435                 440                 445             
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    450                 455                 460                 
Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 
Gly Phe Thr Phe Ser Asp His Trp Met Ser Trp Val Arg Gln Ala Pro 
                485                 490                 495     
Gly Lys Cys Met Glu Trp Ile Gly Asn Ile Gln Tyr Asp Gly Ser Tyr 
            500                 505                 510         
Thr Asn Tyr Ala Pro Ser Leu Lys Asn Arg Phe Thr Ile Ser Arg Asp 
        515                 520                 525             
Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    530                 535                 540                 
Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Gly His Phe Arg Ile Thr Met 
545                 550                 555                 560 
Ala Ser Met Gly Ala Ser Ala Ser Val Tyr Trp Gly Gln Gly Thr Met 
                565                 570                 575     
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
        595                 600                 605             
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    610                 615                 620                 
Arg Thr Ser Gln Asp Ile Gly Asn Ser Leu Arg Trp Phe Gln Gln Lys 
625                 630                 635                 640 
Pro Gly Lys Ala Pro Lys Leu Leu Ile His Gly Ala Thr Asn Leu Ala 
                645                 650                 655     
Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            660                 665                 670         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        675                 680                 685             
Cys Leu Gln His Asn Glu Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
    690                 695                 700                 
Leu Glu Ile Lys 
705             

<210>  108
<211>  220
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  HuPL743-VL3-PHR protein

<400>  108
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210>  109
<211>  703
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  HuPL1642-scfab-hole-PHR protein

<400>  109
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Ser Trp Ser 
            20                  25                  30          
Glu Asn Gln Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Cys Gly Thr Lys Leu 
            100                 105                 110         
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 
    210                 215                 220                 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     
Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         
Val Ala Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        275                 280                 285             
Tyr Thr Phe Thr Arg Asn Thr Met His Trp Ile Lys Gln Ala Pro Gly 
    290                 295                 300                 
Gln Cys Leu Glu Trp Ile Gly Phe Ile Asp Pro His Asn Thr Tyr Thr 
305                 310                 315                 320 
Arg Tyr Asn Gln Lys Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr 
                325                 330                 335     
Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            340                 345                 350         
Thr Ala Val Tyr Tyr Cys Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln 
        355                 360                 365             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
465                 470                 475                 480 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
                485                 490                 495     
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            500                 505                 510         
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
        515                 520                 525             
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    530                 535                 540                 
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
545                 550                 555                 560 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                565                 570                 575     
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            580                 585                 590         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
        595                 600                 605             
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
    610                 615                 620                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
625                 630                 635                 640 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                645                 650                 655     
Asp Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg 
            660                 665                 670         
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        675                 680                 685             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    690                 695                 700             

<210>  110
<211>  704
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  PL1642-T2353-scFv-HC-PHR protein

<400>  110
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Asn 
            20                  25                  30          
Thr Met His Trp Ile Lys Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Phe Ile Asp Pro His Asn Thr Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Pro Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 
Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         
Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    450                 455                 460                 
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
465                 470                 475                 480 
Ser Asp His Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Met 
                485                 490                 495     
Glu Trp Ile Gly Asn Ile Gln Tyr Asp Gly Ser Tyr Thr Asn Tyr Ala 
            500                 505                 510         
Pro Ser Leu Lys Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        515                 520                 525             
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    530                 535                 540                 
Tyr Tyr Cys Thr Arg Gly His Phe Arg Ile Thr Met Ala Ser Met Gly 
545                 550                 555                 560 
Ala Ser Ala Ser Val Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser 
                565                 570                 575     
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            580                 585                 590         
Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        595                 600                 605             
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln 
    610                 615                 620                 
Asp Ile Gly Asn Ser Leu Arg Trp Phe Gln Gln Lys Pro Gly Lys Ala 
625                 630                 635                 640 
Pro Lys Leu Leu Ile His Gly Ala Thr Asn Leu Ala Asn Gly Val Pro 
                645                 650                 655     
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            660                 665                 670         
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His 
        675                 680                 685             
Asn Glu Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
    690                 695                 700                 

<210>  111
<211>  222
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  HuPL1642-VL2-PHR protein

<400>  111
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Ser Trp Ser 
            20                  25                  30          
Glu Asn Gln Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
            100                 105                 110         
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220         

