                         SEQUENCE LISTING

<110>  ϴѧ
 
<120>   һָø߻άƱ;ǵķӦ

<130>  BBA201178A

<150>  CN2020110158021
<151>  2020-09-24

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  714
<212>  PRT
<213>  ˹

<400>  1

Gln Thr Ser Asp Trp Asp Glu Ala Tyr Ser Lys Ala Leu Asp Ser Leu 
1               5                   10                  15      


Ala Lys Leu Ser Gln Asn Glu Lys Ile Gly Ile Val Thr Gly Thr Ser 
            20                  25                  30          


Trp Gln Asn Gly Ser Cys Val Gly Asn Thr Tyr Gln Pro Ser Ser Ile 
        35                  40                  45              


Asp Tyr Pro Ser Leu Cys Leu Gln Asp Gly Pro Leu Gly Ile Arg Tyr 
    50                  55                  60                  


Ala Asn Pro Val Thr Ala Phe Pro Ala Gly Ile Asn Ala Gly Ala Thr 
65                  70                  75                  80  


Trp Asp Arg Ser Leu Ile Lys Asp Arg Gly Ala Ala Leu Gly Glu Glu 
                85                  90                  95      


Ala Lys Ser Leu Gly Val His Val Ser Leu Gly Pro Val Ala Gly Pro 
            100                 105                 110         


Leu Gly Lys Val Pro Gln Gly Gly Arg Leu Trp Glu Gly Phe Ser Val 
        115                 120                 125             


Asp Pro Tyr Leu Ser Gly Val Ala Met Thr Glu Thr Ile Asn Gly Val 
    130                 135                 140                 


Gln Gly Ala Gly Ala Gln Ala Cys Ala Lys His Tyr Ile Gly Asn Glu 
145                 150                 155                 160 


Gln Glu Thr Asn Arg Asn Tyr Ile Asp Ser Thr Ile Asp Asp Arg Ala 
                165                 170                 175     


Phe His Glu Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Asn 
            180                 185                 190         


Val Ala Ser Val Met Cys Ser Tyr Asn Lys Val Asn Gly Thr Tyr Thr 
        195                 200                 205             


Cys Glu Asn Pro Ala Val Leu Asn His Thr Leu Lys Thr Glu Leu Gly 
    210                 215                 220                 


Phe Lys Gly Tyr Ile Met Ser Asp Trp Gly Ala Gln His Thr Thr Ser 
225                 230                 235                 240 


Gly Ser Ala Asn Ala Gly Leu Asp Met Thr Met Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Asn Pro Pro Gly Asn Val Leu Trp Gly Gln Lys Leu Ala Asp Ala 
            260                 265                 270         


Ile Ser Asn Gly Glu Val Glu Gln Ser Arg Leu Asp Asp Met Val Thr 
        275                 280                 285             


Arg Ile Leu Ala Ala Trp Tyr Leu Val Gly Gln Asp Gln Gly Tyr Pro 
    290                 295                 300                 


Ser Val Gln Phe Asn Ser Trp Asn Gly Gly Gln Thr Ser Ala Asn Val 
305                 310                 315                 320 


Thr Gly Asp His Ala Thr Val Val Arg Asn Val Ala Arg Asp Ser Ile 
                325                 330                 335     


Val Leu Leu Lys Asn Asp Asn Asn Thr Leu Pro Leu Ser Lys Pro Asn 
            340                 345                 350         


Ser Leu Ala Ile Ile Gly Ser Asp Ala Ala Val Asn Pro Asp Gly Pro 
        355                 360                 365             


Asn Ala Cys Ser Asp Arg Gly Cys Asp Thr Gly Thr Leu Ala Met Gly 
    370                 375                 380                 


Trp Gly Ser Gly Thr Cys Glu Phe Pro Tyr Leu Val Gly Pro Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asn Gln Ala Asn Ala Asp Gly Thr Thr Ile Thr Ser Ser 
                405                 410                 415     


Thr Thr Asp Ser Thr Ser Asp Gly Ala Ser Ala Ala Gln Asn Ala Asp 
            420                 425                 430         


Val Ala Ile Val Phe Ile Asn Ser Asp Ser Gly Glu Gly Tyr Ile Asn 
        435                 440                 445             


Val Glu Gly Ser Ser Gly Asp Arg Leu Asn Leu Asp Pro Trp His Ser 
    450                 455                 460                 


Gly Asn Glu Leu Val Gln Ala Val Ala Gln Val Asn Gln Lys Thr Ile 
465                 470                 475                 480 


Val Val Ile His Ser Val Gly Pro Leu Val Leu Glu Ser Ile Leu Ala 
                485                 490                 495     


Glu Pro Asn Val Val Ala Ile Val Trp Ala Gly Leu Pro Gly Gln Glu 
            500                 505                 510         


Ser Gly Asn Ala Leu Val Asp Ile Leu Tyr Gly Ser Thr Ala Pro Ser 
        515                 520                 525             


Gly Lys Leu Pro Tyr Thr Ile Ala Lys Gln Glu Ser Asp Tyr Gly Thr 
    530                 535                 540                 


Ser Val Val Asn Gly Asp Asp Asn Phe Ser Glu Gly Ile Phe Val Asp 
545                 550                 555                 560 


Tyr Arg His Phe Asp His Ala Asp Ile Glu Pro Arg Tyr Glu Phe Gly 
                565                 570                 575     


Tyr Gly Leu Ser Tyr Thr Thr Phe Asn Tyr Ser Gly Leu Ala Val Asp 
            580                 585                 590         


Val Thr Val Ser Ala Gly Ala Thr Ser Gly Glu Thr Val Ser Gly Gly 
        595                 600                 605             


Pro Ser Asp Leu Phe Thr Glu Val Gly Thr Val Ser Ala Ser Val Gln 
    610                 615                 620                 


Asn Thr Gly Gln Val Thr Gly Ala Glu Val Ala Gln Leu Tyr Ile Gly 
625                 630                 635                 640 


Leu Pro Ser Ser Ala Pro Ser Ala Pro Pro Lys Gln Leu Arg Gly Phe 
                645                 650                 655     


Gln Lys Ile Leu Leu Glu Ala Asp Glu Ser Asp Thr Ala Ser Phe Ser 
            660                 665                 670         


Leu Thr Arg Arg Asp Leu Ser Tyr Trp Asp Thr Gln Glu Gln Lys Trp 
        675                 680                 685             


Val Val Pro Ser Gly Glu Phe Ser Val Tyr Val Gly Ser Ser Ser Arg 
    690                 695                 700                 


Asp Ile Arg Leu Thr Asp Thr Phe Thr Val 
705                 710                 


<210>  2
<211>  2145
<212>  DNA
<213>  ˹

<400>  2
cagacatctg attgggatga ggcatactcc aaggcactcg actccctcgc caagctcagt     60

cagaatgaaa agataggcat cgtgacggga acaagttggc agaacggttc ttgtgtaggc    120

aacacgtatc agccttcctc aatcgactac ccgtctctct gtctccaaga tggccctctt    180

ggtatccgat atgcaaaccc cgtcacggct tttcccgccg gaatcaatgc gggagctacc    240

tgggatcgct ctttgattaa agaccgcggt gctgctctag gagaagaagc aaagtctctt    300

ggggttcatg tatccttggg ccctgttgca ggaccgctgg gcaaagtgcc tcaaggagga    360

agactgtggg aaggattttc ggtcgaccca tatctcagtg gagtcgccat gacggaaacg    420

atcaacggtg ttcagggtgc tggagcccag gcgtgcgcga aacattatat tgggaatgaa    480

caggaaacga atcgcaacta catcgattcg accattgacg accgtgcctt tcatgaactc    540

tacctctggc cctttgcgga tgctgtccgc gcaaacgtcg ccagcgtgat gtgctcgtat    600

aataaagtga atggtactta tacctgtgag aatcctgcag tgctcaatca cactcttaaa    660

acagaactgg gattcaaagg ctacataatg agcgactggg gcgcgcaaca cactacaagc    720

ggcagtgcta acgctggcct ggatatgacc atgcctggaa gtgatctgag taatcctccc    780

ggtaatgttc tgtggggtca gaagcttgca gacgcgattt cgaatggaga agttgaacag    840

tctagattgg acgacatggt aacccgaatt cttgcagctt ggtatcttgt tggccaggat    900

caaggctacc catctgtaca gttcaactcg tggaatggcg gccagacctc agcgaatgtg    960

acaggagacc atgccacggt tgtccgtaat gtggcgaggg attcgattgt gctgctgaag   1020

aatgataaca atactcttcc tctctctaag ccaaacagcc tggctatcat cggaagtgat   1080

gcggcagtga accccgacgg tccaaatgcc tgtagtgatc ggggctgtga tactggaact   1140

ctggcaatgg gctggggaag tggaacatgc gagttccctt accttgttgg tccgttggaa   1200

gccattaaaa accaggcaaa tgcggatgga acaacaatca cctccagtac cacggattca   1260

actagcgatg gtgcttcagc tgctcagaac gctgacgtgg ccattgtatt tatcaattcg   1320

gattcgggtg aaggttacat caatgttgaa ggcagctctg gtgaccgcct caaccttgac   1380

ccatggcact ccggcaacga attggtccaa gcggtcgccc aggtcaacca gaagaccatc   1440

gtggtgattc acagtgttgg ccctcttgtt ctagaatcaa tcctcgcaga accgaacgtg   1500

gttgccattg tttgggctgg tctccctggt caagaaagcg gcaatgcatt ggttgatatt   1560

ctgtacggat caacagcccc aagcggaaag ttgccgtata caattgccaa gcaggagtcg   1620

gattatggca cttctgtcgt caatggcgac gataactttt ctgagggaat tttcgtcgac   1680

tatcgtcact ttgatcacgc ggatattgaa cctagatacg aatttggcta cgggttgtca   1740

tacaccacgt tcaactactc tggtctcgct gttgatgtga ctgtctcagc tggtgctacc   1800

tctggggaaa ctgtctccgg aggcccatca gatttgttca cggaagtggg taccgtctca   1860

gccagtgtac aaaacaccgg acaggtgacg ggtgctgagg tcgcccaatt gtatatcggt   1920

ttgccctcat cggcaccatc tgcaccgccg aaacagctgc gaggctttca gaaaatcctc   1980

ctcgaagccg atgagtctga cactgcgagc ttctcgctca ccagaagaga ccttagctat   2040

tgggatacac aggaacagaa atgggtggtg cccagtggcg agttctcggt atacgttgga   2100

agctccagcc gcgatattcg actaacagac actttcactg tttga                   2145


<210>  3
<211>  33
<212>  DNA
<213>  ˹

<400>  3
acgggaacaa gttgggggaa cggttcttgt gta                                  33


<210>  4
<211>  33
<212>  DNA
<213>  ˹

<400>  4
tacacaagaa ccgttccccc aacttgttcc cgt                                  33


<210>  5
<211>  33
<212>  DNA
<213>  ˹

<400>  5
caagttggat gaacggttct tgtgtaggca aca                                  33


<210>  6
<211>  33
<212>  DNA
<213>  ˹

<400>  6
gaaccgttca tccaacttgt tcccgtcacg atg                                  33


<210>  7
<211>  33
<212>  DNA
<213>  ˹

<400>  7
tgtgctcgtg gaataaagtg aatggtactt ata                                  33


<210>  8
<211>  33
<212>  DNA
<213>  ˹

<400>  8
actttattcc acgagcacat cacgctggcg acg                                  33


<210>  9
<211>  714
<212>  PRT
<213>  ˹

<400>  9

Gln Thr Ser Asp Trp Asp Glu Ala Tyr Ser Lys Ala Leu Asp Ser Leu 
1               5                   10                  15      


Ala Lys Leu Ser Gln Asn Glu Lys Ile Gly Ile Val Thr Gly Thr Ser 
            20                  25                  30          


Trp Gly Asn Gly Ser Cys Val Gly Asn Thr Tyr Gln Pro Ser Ser Ile 
        35                  40                  45              


Asp Tyr Pro Ser Leu Cys Leu Gln Asp Gly Pro Leu Gly Ile Arg Tyr 
    50                  55                  60                  


Ala Asn Pro Val Thr Ala Phe Pro Ala Gly Ile Asn Ala Gly Ala Thr 
65                  70                  75                  80  


Trp Asp Arg Ser Leu Ile Lys Asp Arg Gly Ala Ala Leu Gly Glu Glu 
                85                  90                  95      


Ala Lys Ser Leu Gly Val His Val Ser Leu Gly Pro Val Ala Gly Pro 
            100                 105                 110         


Leu Gly Lys Val Pro Gln Gly Gly Arg Leu Trp Glu Gly Phe Ser Val 
        115                 120                 125             


Asp Pro Tyr Leu Ser Gly Val Ala Met Thr Glu Thr Ile Asn Gly Val 
    130                 135                 140                 


Gln Gly Ala Gly Ala Gln Ala Cys Ala Lys His Tyr Ile Gly Asn Glu 
145                 150                 155                 160 


Gln Glu Thr Asn Arg Asn Tyr Ile Asp Ser Thr Ile Asp Asp Arg Ala 
                165                 170                 175     


Phe His Glu Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Asn 
            180                 185                 190         


Val Ala Ser Val Met Cys Ser Tyr Asn Lys Val Asn Gly Thr Tyr Thr 
        195                 200                 205             


Cys Glu Asn Pro Ala Val Leu Asn His Thr Leu Lys Thr Glu Leu Gly 
    210                 215                 220                 


Phe Lys Gly Tyr Ile Met Ser Asp Trp Gly Ala Gln His Thr Thr Ser 
225                 230                 235                 240 


Gly Ser Ala Asn Ala Gly Leu Asp Met Thr Met Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Asn Pro Pro Gly Asn Val Leu Trp Gly Gln Lys Leu Ala Asp Ala 
            260                 265                 270         


Ile Ser Asn Gly Glu Val Glu Gln Ser Arg Leu Asp Asp Met Val Thr 
        275                 280                 285             


Arg Ile Leu Ala Ala Trp Tyr Leu Val Gly Gln Asp Gln Gly Tyr Pro 
    290                 295                 300                 


Ser Val Gln Phe Asn Ser Trp Asn Gly Gly Gln Thr Ser Ala Asn Val 
305                 310                 315                 320 


Thr Gly Asp His Ala Thr Val Val Arg Asn Val Ala Arg Asp Ser Ile 
                325                 330                 335     


Val Leu Leu Lys Asn Asp Asn Asn Thr Leu Pro Leu Ser Lys Pro Asn 
            340                 345                 350         


Ser Leu Ala Ile Ile Gly Ser Asp Ala Ala Val Asn Pro Asp Gly Pro 
        355                 360                 365             


Asn Ala Cys Ser Asp Arg Gly Cys Asp Thr Gly Thr Leu Ala Met Gly 
    370                 375                 380                 


Trp Gly Ser Gly Thr Cys Glu Phe Pro Tyr Leu Val Gly Pro Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asn Gln Ala Asn Ala Asp Gly Thr Thr Ile Thr Ser Ser 
                405                 410                 415     


Thr Thr Asp Ser Thr Ser Asp Gly Ala Ser Ala Ala Gln Asn Ala Asp 
            420                 425                 430         


Val Ala Ile Val Phe Ile Asn Ser Asp Ser Gly Glu Gly Tyr Ile Asn 
        435                 440                 445             


Val Glu Gly Ser Ser Gly Asp Arg Leu Asn Leu Asp Pro Trp His Ser 
    450                 455                 460                 


Gly Asn Glu Leu Val Gln Ala Val Ala Gln Val Asn Gln Lys Thr Ile 
465                 470                 475                 480 


Val Val Ile His Ser Val Gly Pro Leu Val Leu Glu Ser Ile Leu Ala 
                485                 490                 495     


Glu Pro Asn Val Val Ala Ile Val Trp Ala Gly Leu Pro Gly Gln Glu 
            500                 505                 510         


Ser Gly Asn Ala Leu Val Asp Ile Leu Tyr Gly Ser Thr Ala Pro Ser 
        515                 520                 525             


Gly Lys Leu Pro Tyr Thr Ile Ala Lys Gln Glu Ser Asp Tyr Gly Thr 
    530                 535                 540                 


Ser Val Val Asn Gly Asp Asp Asn Phe Ser Glu Gly Ile Phe Val Asp 
545                 550                 555                 560 


Tyr Arg His Phe Asp His Ala Asp Ile Glu Pro Arg Tyr Glu Phe Gly 
                565                 570                 575     


Tyr Gly Leu Ser Tyr Thr Thr Phe Asn Tyr Ser Gly Leu Ala Val Asp 
            580                 585                 590         


Val Thr Val Ser Ala Gly Ala Thr Ser Gly Glu Thr Val Ser Gly Gly 
        595                 600                 605             


Pro Ser Asp Leu Phe Thr Glu Val Gly Thr Val Ser Ala Ser Val Gln 
    610                 615                 620                 


Asn Thr Gly Gln Val Thr Gly Ala Glu Val Ala Gln Leu Tyr Ile Gly 
625                 630                 635                 640 


Leu Pro Ser Ser Ala Pro Ser Ala Pro Pro Lys Gln Leu Arg Gly Phe 
                645                 650                 655     


Gln Lys Ile Leu Leu Glu Ala Asp Glu Ser Asp Thr Ala Ser Phe Ser 
            660                 665                 670         


Leu Thr Arg Arg Asp Leu Ser Tyr Trp Asp Thr Gln Glu Gln Lys Trp 
        675                 680                 685             


Val Val Pro Ser Gly Glu Phe Ser Val Tyr Val Gly Ser Ser Ser Arg 
    690                 695                 700                 


Asp Ile Arg Leu Thr Asp Thr Phe Thr Val 
705                 710                 


<210>  10
<211>  714
<212>  PRT
<213>  ˹

<400>  10

Gln Thr Ser Asp Trp Asp Glu Ala Tyr Ser Lys Ala Leu Asp Ser Leu 
1               5                   10                  15      


Ala Lys Leu Ser Gln Asn Glu Lys Ile Gly Ile Val Thr Gly Thr Ser 
            20                  25                  30          


Trp Met Asn Gly Ser Cys Val Gly Asn Thr Tyr Gln Pro Ser Ser Ile 
        35                  40                  45              


Asp Tyr Pro Ser Leu Cys Leu Gln Asp Gly Pro Leu Gly Ile Arg Tyr 
    50                  55                  60                  


Ala Asn Pro Val Thr Ala Phe Pro Ala Gly Ile Asn Ala Gly Ala Thr 
65                  70                  75                  80  


Trp Asp Arg Ser Leu Ile Lys Asp Arg Gly Ala Ala Leu Gly Glu Glu 
                85                  90                  95      


Ala Lys Ser Leu Gly Val His Val Ser Leu Gly Pro Val Ala Gly Pro 
            100                 105                 110         


Leu Gly Lys Val Pro Gln Gly Gly Arg Leu Trp Glu Gly Phe Ser Val 
        115                 120                 125             


Asp Pro Tyr Leu Ser Gly Val Ala Met Thr Glu Thr Ile Asn Gly Val 
    130                 135                 140                 


Gln Gly Ala Gly Ala Gln Ala Cys Ala Lys His Tyr Ile Gly Asn Glu 
145                 150                 155                 160 


Gln Glu Thr Asn Arg Asn Tyr Ile Asp Ser Thr Ile Asp Asp Arg Ala 
                165                 170                 175     


Phe His Glu Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Asn 
            180                 185                 190         


Val Ala Ser Val Met Cys Ser Tyr Asn Lys Val Asn Gly Thr Tyr Thr 
        195                 200                 205             


Cys Glu Asn Pro Ala Val Leu Asn His Thr Leu Lys Thr Glu Leu Gly 
    210                 215                 220                 


Phe Lys Gly Tyr Ile Met Ser Asp Trp Gly Ala Gln His Thr Thr Ser 
225                 230                 235                 240 


Gly Ser Ala Asn Ala Gly Leu Asp Met Thr Met Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Asn Pro Pro Gly Asn Val Leu Trp Gly Gln Lys Leu Ala Asp Ala 
            260                 265                 270         


Ile Ser Asn Gly Glu Val Glu Gln Ser Arg Leu Asp Asp Met Val Thr 
        275                 280                 285             


Arg Ile Leu Ala Ala Trp Tyr Leu Val Gly Gln Asp Gln Gly Tyr Pro 
    290                 295                 300                 


Ser Val Gln Phe Asn Ser Trp Asn Gly Gly Gln Thr Ser Ala Asn Val 
305                 310                 315                 320 


Thr Gly Asp His Ala Thr Val Val Arg Asn Val Ala Arg Asp Ser Ile 
                325                 330                 335     


Val Leu Leu Lys Asn Asp Asn Asn Thr Leu Pro Leu Ser Lys Pro Asn 
            340                 345                 350         


Ser Leu Ala Ile Ile Gly Ser Asp Ala Ala Val Asn Pro Asp Gly Pro 
        355                 360                 365             


Asn Ala Cys Ser Asp Arg Gly Cys Asp Thr Gly Thr Leu Ala Met Gly 
    370                 375                 380                 


Trp Gly Ser Gly Thr Cys Glu Phe Pro Tyr Leu Val Gly Pro Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asn Gln Ala Asn Ala Asp Gly Thr Thr Ile Thr Ser Ser 
                405                 410                 415     


Thr Thr Asp Ser Thr Ser Asp Gly Ala Ser Ala Ala Gln Asn Ala Asp 
            420                 425                 430         


Val Ala Ile Val Phe Ile Asn Ser Asp Ser Gly Glu Gly Tyr Ile Asn 
        435                 440                 445             


Val Glu Gly Ser Ser Gly Asp Arg Leu Asn Leu Asp Pro Trp His Ser 
    450                 455                 460                 


Gly Asn Glu Leu Val Gln Ala Val Ala Gln Val Asn Gln Lys Thr Ile 
465                 470                 475                 480 


Val Val Ile His Ser Val Gly Pro Leu Val Leu Glu Ser Ile Leu Ala 
                485                 490                 495     


Glu Pro Asn Val Val Ala Ile Val Trp Ala Gly Leu Pro Gly Gln Glu 
            500                 505                 510         


Ser Gly Asn Ala Leu Val Asp Ile Leu Tyr Gly Ser Thr Ala Pro Ser 
        515                 520                 525             


Gly Lys Leu Pro Tyr Thr Ile Ala Lys Gln Glu Ser Asp Tyr Gly Thr 
    530                 535                 540                 


Ser Val Val Asn Gly Asp Asp Asn Phe Ser Glu Gly Ile Phe Val Asp 
545                 550                 555                 560 


Tyr Arg His Phe Asp His Ala Asp Ile Glu Pro Arg Tyr Glu Phe Gly 
                565                 570                 575     


Tyr Gly Leu Ser Tyr Thr Thr Phe Asn Tyr Ser Gly Leu Ala Val Asp 
            580                 585                 590         


Val Thr Val Ser Ala Gly Ala Thr Ser Gly Glu Thr Val Ser Gly Gly 
        595                 600                 605             


Pro Ser Asp Leu Phe Thr Glu Val Gly Thr Val Ser Ala Ser Val Gln 
    610                 615                 620                 


Asn Thr Gly Gln Val Thr Gly Ala Glu Val Ala Gln Leu Tyr Ile Gly 
625                 630                 635                 640 


Leu Pro Ser Ser Ala Pro Ser Ala Pro Pro Lys Gln Leu Arg Gly Phe 
                645                 650                 655     


Gln Lys Ile Leu Leu Glu Ala Asp Glu Ser Asp Thr Ala Ser Phe Ser 
            660                 665                 670         


Leu Thr Arg Arg Asp Leu Ser Tyr Trp Asp Thr Gln Glu Gln Lys Trp 
        675                 680                 685             


Val Val Pro Ser Gly Glu Phe Ser Val Tyr Val Gly Ser Ser Ser Arg 
    690                 695                 700                 


Asp Ile Arg Leu Thr Asp Thr Phe Thr Val 
705                 710                 


<210>  11
<211>  714
<212>  PRT
<213>  ˹

<400>  11

Gln Thr Ser Asp Trp Asp Glu Ala Tyr Ser Lys Ala Leu Asp Ser Leu 
1               5                   10                  15      


Ala Lys Leu Ser Gln Asn Glu Lys Ile Gly Ile Val Thr Gly Thr Ser 
            20                  25                  30          


Trp Gln Asn Gly Ser Cys Val Gly Asn Thr Tyr Gln Pro Ser Ser Ile 
        35                  40                  45              


Asp Tyr Pro Ser Leu Cys Leu Gln Asp Gly Pro Leu Gly Ile Arg Tyr 
    50                  55                  60                  


Ala Asn Pro Val Thr Ala Phe Pro Ala Gly Ile Asn Ala Gly Ala Thr 
65                  70                  75                  80  


Trp Asp Arg Ser Leu Ile Lys Asp Arg Gly Ala Ala Leu Gly Glu Glu 
                85                  90                  95      


Ala Lys Ser Leu Gly Val His Val Ser Leu Gly Pro Val Ala Gly Pro 
            100                 105                 110         


Leu Gly Lys Val Pro Gln Gly Gly Arg Leu Trp Glu Gly Phe Ser Val 
        115                 120                 125             


Asp Pro Tyr Leu Ser Gly Val Ala Met Thr Glu Thr Ile Asn Gly Val 
    130                 135                 140                 


Gln Gly Ala Gly Ala Gln Ala Cys Ala Lys His Tyr Ile Gly Asn Glu 
145                 150                 155                 160 


Gln Glu Thr Asn Arg Asn Tyr Ile Asp Ser Thr Ile Asp Asp Arg Ala 
                165                 170                 175     


Phe His Glu Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Asn 
            180                 185                 190         


Val Ala Ser Val Met Cys Ser Phe Asn Lys Val Asn Gly Thr Tyr Thr 
        195                 200                 205             


Cys Glu Asn Pro Ala Val Leu Asn His Thr Leu Lys Thr Glu Leu Gly 
    210                 215                 220                 


Phe Lys Gly Tyr Ile Met Ser Asp Trp Gly Ala Gln His Thr Thr Ser 
225                 230                 235                 240 


Gly Ser Ala Asn Ala Gly Leu Asp Met Thr Met Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Asn Pro Pro Gly Asn Val Leu Trp Gly Gln Lys Leu Ala Asp Ala 
            260                 265                 270         


Ile Ser Asn Gly Glu Val Glu Gln Ser Arg Leu Asp Asp Met Val Thr 
        275                 280                 285             


Arg Ile Leu Ala Ala Trp Tyr Leu Val Gly Gln Asp Gln Gly Tyr Pro 
    290                 295                 300                 


Ser Val Gln Phe Asn Ser Trp Asn Gly Gly Gln Thr Ser Ala Asn Val 
305                 310                 315                 320 


Thr Gly Asp His Ala Thr Val Val Arg Asn Val Ala Arg Asp Ser Ile 
                325                 330                 335     


Val Leu Leu Lys Asn Asp Asn Asn Thr Leu Pro Leu Ser Lys Pro Asn 
            340                 345                 350         


Ser Leu Ala Ile Ile Gly Ser Asp Ala Ala Val Asn Pro Asp Gly Pro 
        355                 360                 365             


Asn Ala Cys Ser Asp Arg Gly Cys Asp Thr Gly Thr Leu Ala Met Gly 
    370                 375                 380                 


Trp Gly Ser Gly Thr Cys Glu Phe Pro Tyr Leu Val Gly Pro Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asn Gln Ala Asn Ala Asp Gly Thr Thr Ile Thr Ser Ser 
                405                 410                 415     


Thr Thr Asp Ser Thr Ser Asp Gly Ala Ser Ala Ala Gln Asn Ala Asp 
            420                 425                 430         


Val Ala Ile Val Phe Ile Asn Ser Asp Ser Gly Glu Gly Tyr Ile Asn 
        435                 440                 445             


Val Glu Gly Ser Ser Gly Asp Arg Leu Asn Leu Asp Pro Trp His Ser 
    450                 455                 460                 


Gly Asn Glu Leu Val Gln Ala Val Ala Gln Val Asn Gln Lys Thr Ile 
465                 470                 475                 480 


Val Val Ile His Ser Val Gly Pro Leu Val Leu Glu Ser Ile Leu Ala 
                485                 490                 495     


Glu Pro Asn Val Val Ala Ile Val Trp Ala Gly Leu Pro Gly Gln Glu 
            500                 505                 510         


Ser Gly Asn Ala Leu Val Asp Ile Leu Tyr Gly Ser Thr Ala Pro Ser 
        515                 520                 525             


Gly Lys Leu Pro Tyr Thr Ile Ala Lys Gln Glu Ser Asp Tyr Gly Thr 
    530                 535                 540                 


Ser Val Val Asn Gly Asp Asp Asn Phe Ser Glu Gly Ile Phe Val Asp 
545                 550                 555                 560 


Tyr Arg His Phe Asp His Ala Asp Ile Glu Pro Arg Tyr Glu Phe Gly 
                565                 570                 575     


Tyr Gly Leu Ser Tyr Thr Thr Phe Asn Tyr Ser Gly Leu Ala Val Asp 
            580                 585                 590         


Val Thr Val Ser Ala Gly Ala Thr Ser Gly Glu Thr Val Ser Gly Gly 
        595                 600                 605             


Pro Ser Asp Leu Phe Thr Glu Val Gly Thr Val Ser Ala Ser Val Gln 
    610                 615                 620                 


Asn Thr Gly Gln Val Thr Gly Ala Glu Val Ala Gln Leu Tyr Ile Gly 
625                 630                 635                 640 


Leu Pro Ser Ser Ala Pro Ser Ala Pro Pro Lys Gln Leu Arg Gly Phe 
                645                 650                 655     


Gln Lys Ile Leu Leu Glu Ala Asp Glu Ser Asp Thr Ala Ser Phe Ser 
            660                 665                 670         


Leu Thr Arg Arg Asp Leu Ser Tyr Trp Asp Thr Gln Glu Gln Lys Trp 
        675                 680                 685             


Val Val Pro Ser Gly Glu Phe Ser Val Tyr Val Gly Ser Ser Ser Arg 
    690                 695                 700                 


Asp Ile Arg Leu Thr Asp Thr Phe Thr Val 
705                 710                 


<210>  12
<211>  714
<212>  PRT
<213>  ˹

<400>  12

Gln Thr Ser Asp Trp Asp Glu Ala Tyr Ser Lys Ala Leu Asp Ser Leu 
1               5                   10                  15      


Ala Lys Leu Ser Gln Asn Glu Lys Ile Gly Ile Val Thr Gly Thr Ser 
            20                  25                  30          


Trp Gly Asn Gly Ser Cys Val Gly Asn Thr Tyr Gln Pro Ser Ser Ile 
        35                  40                  45              


Asp Tyr Pro Ser Leu Cys Leu Gln Asp Gly Pro Leu Gly Ile Arg Tyr 
    50                  55                  60                  


Ala Asn Pro Val Thr Ala Phe Pro Ala Gly Ile Asn Ala Gly Ala Thr 
65                  70                  75                  80  


Trp Asp Arg Ser Leu Ile Lys Asp Arg Gly Ala Ala Leu Gly Glu Glu 
                85                  90                  95      


Ala Lys Ser Leu Gly Val His Val Ser Leu Gly Pro Val Ala Gly Pro 
            100                 105                 110         


Leu Gly Lys Val Pro Gln Gly Gly Arg Leu Trp Glu Gly Phe Ser Val 
        115                 120                 125             


Asp Pro Tyr Leu Ser Gly Val Ala Met Thr Glu Thr Ile Asn Gly Val 
    130                 135                 140                 


Gln Gly Ala Gly Ala Gln Ala Cys Ala Lys His Tyr Ile Gly Asn Glu 
145                 150                 155                 160 


Gln Glu Thr Asn Arg Asn Tyr Ile Asp Ser Thr Ile Asp Asp Arg Ala 
                165                 170                 175     


Phe His Glu Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Asn 
            180                 185                 190         


Val Ala Ser Val Met Cys Ser Phe Asn Lys Val Asn Gly Thr Tyr Thr 
        195                 200                 205             


Cys Glu Asn Pro Ala Val Leu Asn His Thr Leu Lys Thr Glu Leu Gly 
    210                 215                 220                 


Phe Lys Gly Tyr Ile Met Ser Asp Trp Gly Ala Gln His Thr Thr Ser 
225                 230                 235                 240 


Gly Ser Ala Asn Ala Gly Leu Asp Met Thr Met Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Asn Pro Pro Gly Asn Val Leu Trp Gly Gln Lys Leu Ala Asp Ala 
            260                 265                 270         


Ile Ser Asn Gly Glu Val Glu Gln Ser Arg Leu Asp Asp Met Val Thr 
        275                 280                 285             


Arg Ile Leu Ala Ala Trp Tyr Leu Val Gly Gln Asp Gln Gly Tyr Pro 
    290                 295                 300                 


Ser Val Gln Phe Asn Ser Trp Asn Gly Gly Gln Thr Ser Ala Asn Val 
305                 310                 315                 320 


Thr Gly Asp His Ala Thr Val Val Arg Asn Val Ala Arg Asp Ser Ile 
                325                 330                 335     


Val Leu Leu Lys Asn Asp Asn Asn Thr Leu Pro Leu Ser Lys Pro Asn 
            340                 345                 350         


Ser Leu Ala Ile Ile Gly Ser Asp Ala Ala Val Asn Pro Asp Gly Pro 
        355                 360                 365             


Asn Ala Cys Ser Asp Arg Gly Cys Asp Thr Gly Thr Leu Ala Met Gly 
    370                 375                 380                 


Trp Gly Ser Gly Thr Cys Glu Phe Pro Tyr Leu Val Gly Pro Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asn Gln Ala Asn Ala Asp Gly Thr Thr Ile Thr Ser Ser 
                405                 410                 415     


Thr Thr Asp Ser Thr Ser Asp Gly Ala Ser Ala Ala Gln Asn Ala Asp 
            420                 425                 430         


Val Ala Ile Val Phe Ile Asn Ser Asp Ser Gly Glu Gly Tyr Ile Asn 
        435                 440                 445             


Val Glu Gly Ser Ser Gly Asp Arg Leu Asn Leu Asp Pro Trp His Ser 
    450                 455                 460                 


Gly Asn Glu Leu Val Gln Ala Val Ala Gln Val Asn Gln Lys Thr Ile 
465                 470                 475                 480 


Val Val Ile His Ser Val Gly Pro Leu Val Leu Glu Ser Ile Leu Ala 
                485                 490                 495     


Glu Pro Asn Val Val Ala Ile Val Trp Ala Gly Leu Pro Gly Gln Glu 
            500                 505                 510         


Ser Gly Asn Ala Leu Val Asp Ile Leu Tyr Gly Ser Thr Ala Pro Ser 
        515                 520                 525             


Gly Lys Leu Pro Tyr Thr Ile Ala Lys Gln Glu Ser Asp Tyr Gly Thr 
    530                 535                 540                 


Ser Val Val Asn Gly Asp Asp Asn Phe Ser Glu Gly Ile Phe Val Asp 
545                 550                 555                 560 


Tyr Arg His Phe Asp His Ala Asp Ile Glu Pro Arg Tyr Glu Phe Gly 
                565                 570                 575     


Tyr Gly Leu Ser Tyr Thr Thr Phe Asn Tyr Ser Gly Leu Ala Val Asp 
            580                 585                 590         


Val Thr Val Ser Ala Gly Ala Thr Ser Gly Glu Thr Val Ser Gly Gly 
        595                 600                 605             


Pro Ser Asp Leu Phe Thr Glu Val Gly Thr Val Ser Ala Ser Val Gln 
    610                 615                 620                 


Asn Thr Gly Gln Val Thr Gly Ala Glu Val Ala Gln Leu Tyr Ile Gly 
625                 630                 635                 640 


Leu Pro Ser Ser Ala Pro Ser Ala Pro Pro Lys Gln Leu Arg Gly Phe 
                645                 650                 655     


Gln Lys Ile Leu Leu Glu Ala Asp Glu Ser Asp Thr Ala Ser Phe Ser 
            660                 665                 670         


Leu Thr Arg Arg Asp Leu Ser Tyr Trp Asp Thr Gln Glu Gln Lys Trp 
        675                 680                 685             


Val Val Pro Ser Gly Glu Phe Ser Val Tyr Val Gly Ser Ser Ser Arg 
    690                 695                 700                 


Asp Ile Arg Leu Thr Asp Thr Phe Thr Val 
705                 710                 


