                         б

<110>  ͼ΢Ƽ޹˾
 
<120>  GLP-1R/GCGR˫е㼤ƲԸصĸά

<130>  GD2300-20P424695

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<400>  1

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  2
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  2

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  3
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CO2H

<400>  3

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  4
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CH3

<400>  4

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  5

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  6
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  7
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Arg Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  8
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Arg Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  9
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala His Asp Phe Val Glu Trp Leu Leu Asn Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  10
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Arg Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  11
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CH3

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Arg Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  12
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  12

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Asn Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  13
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CO2H

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Asn Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  14
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CH3

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Asn Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  15
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Ala Ala Lys Glu Phe Ile Glu Trp Leu Leu Asn Gly Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  16
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<400>  16

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Lys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  17
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  18
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-CO(CH2)16CO2H

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  19
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CH3

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  20
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa=Nle

<400>  20

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  21
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa=Nle

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  22
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)16CO2H

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  23
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-Glu-CO(CH2)14CH3

<400>  23

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  24
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-CO(CH2)16CO2H

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa=Nle

<400>  24

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  25
<211>  40
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=D-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  LysĲ-PEG2-PEG2-CO(CH2)14CH3

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Leu Asn Thr Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  26
<211>  39
<212>  PRT
<213>  ˹


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = AibD-Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa=LysTyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa=LysTyr

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa= GluLys

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa=LysArg

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa=ArgAla

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa=HisGlnLys

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa=AspGlu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa= IIeVal

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=GluGln

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa=MetLeuNle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa=AsnAspArg

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa=GlyThr

<400>  26

His Xaa Gln Gly Thr Phe Thr Ser Asp Xaa Ser Lys Xaa Leu Asp Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  

