                         SEQUENCE LISTING

<110>  A2 Biotherapeutics, Inc.
 
<120>  ENGINEERED IMMUNE CELLS

<130>  A2TH-001/01WO 36235/11

<150>  63/081,229
<151>  2020-09-21

<150>  63/081,231
<151>  2020-09-21

<150>  63/081,237
<151>  2020-09-21

<150>  63/081,242
<151>  2020-09-21

<150>  63/081,248
<151>  2020-09-21

<150>  63/081,250
<151>  2020-09-21

<150>  63/081,256
<151>  2020-09-21

<150>  63/081,258
<151>  2020-09-21

<160>  391   

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge

<400>  1

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  2
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge

<400>  2
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  3
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  3

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  4
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  4
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  5
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  5

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  6
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  6
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta transmembrane domain

<400>  7

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  8
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2R beta transmembrane domain

<400>  8
attccgtggc tcggccacct cctcgtgggc ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  9

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  10
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  10
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  11
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu His Met Gln Ala Leu Pro Pro Arg 
        35                  40              


<210>  12
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  12
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttgcacat gcaggccctg      120

ccccctcgc                                                              129


<210>  13
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  13

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  14
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  14
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  15
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2-Rbeta intracellular domain

<400>  15

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  16
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2-Rbeta intracellular domain

<400>  16
aactgcagga acaccgggcc atggctgaag aaggtcctga agtgtaacac cccagacccc       60

tcgaagttct tttcccagct gagctcagag catggaggcg acgtccagaa gtggctctct      120

tcgcccttcc cctcatcgtc cttcagccct ggcggcctgg cacctgagat ctcgccacta      180

gaagtgctgg agagggacaa ggtgacgcag ctgctccccc tgaacactga tgcctacttg      240

tctctccaag aactccaggg tcaggaccca actcacttgg tg                         282


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 recruitment motif

<400>  17

Tyr Leu Ser Leu 
1               


<210>  18
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  19
<211>  300
<212>  DNA
<213>  CD3 epsilon intracellular domain

<400>  19
aagaatagaa aggccaaggc caagcctgtg acacgaggag cgggtgctgg cggcaggcaa       60

aggggacaaa acaaggagag gccaccacct gttcccaacc cagactatga gcccatccgg      120

aaaggccagc gggacctgta ttctggcctg aatcagcgca gaatcggcgg aagcaggagc      180

aagcggagca gactgctgca cagcgactac atgaacatga ccccccggag gcctggcccc      240

acccggaagc actaccagcc ctacgcccct cccagggatt tcgccgccta ccggagctag      300


<210>  20
<211>  69
<212>  DNA
<213>  Artificial SEquence

<220>
<223>  TCR beta transmembrane domain

<400>  20
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc       60

ctcgtgctg                                                               69


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM motif


<220>
<221>  X
<222>  (2)..(3)
<223>  X can be any amino acid

<400>  21

Tyr Xaa Xaa Leu 
1               


<210>  22
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma intracellular domain

<400>  22
ggacaggatg gagttcgcca gtcgagagct tcagacaagc agactctgtt gcccaatgac       60

cagctctacc agcccctcaa ggatcgagaa gatgaccagt acagccacct tcaaggaaac      120

cagttgagga ggaatggcgg aagcaggagc aagcggagca gactgctgca cagcgactac      180

atgaacatga ccccccggag gcctggcccc acccggaagc actaccagcc ctacgcccct      240

cccagggatt tcgccgccta ccggagctag                                       270


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTY peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is R or G

<220>
<221>  X
<222>  (6)..(6)
<223>  X is E or A

<220>
<221>  X
<222>  (8)..(8)
<223>  X is V or P

<400>  23

Xaa Glu Ser Glu Glu Xaa Ser Xaa Ser Leu 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RPSY peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is V or L

<400>  24

Thr Ile Arg Tyr Pro Asp Pro Xaa Ile 
1               5                   


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTY peptide


<220>
<221>  X
<222>  (5)..(5)
<223>  X is H or R

<220>
<221>  X
<222>  (7)..(7)
<223>  X is D or N

<400>  25

Leu Pro His Asn Xaa Thr Xaa Leu 
1               5               


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha transmembrane domain

<400>  26

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  27
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR alpha transmembrane domain

<400>  27
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg       60

cggctgtgg                                                               69


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta transmembrane domain

<400>  28

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrane domain

<400>  29

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  30
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 delta intracellular domain

<400>  30

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Gly Gly Ser 
        35                  40                  45              


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    50                  55                  60                  


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
65                  70                  75                  80  


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  


<210>  31
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta intracellular domain

<400>  31
ggacatgaga ctggaaggct gtctggggct gccgacacac aagctctgtt gaggaatgac       60

caggtctatc agcccctccg agatcgagat gatgctcagt acagccacct tggaggaaac      120

tgggctcgga acaagggcgg aagcaggagc aagcggagca gactgctgca cagcgactac      180

atgaacatga ccccccggag gcctggcccc acccggaagc actaccagcc ctacgcccct      240

cccagggatt tcgccgccta ccggagcta                                        269


<210>  32
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon intracellular domain

<400>  32

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile Gly Gly Ser Arg Ser Lys Arg Ser Arg 
    50                  55                  60                  


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
65                  70                  75                  80  


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                85                  90                  95      


Tyr Arg Ser 
            


<210>  33
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 gamma intracellular domain

<400>  33

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn Gly Gly Ser 
        35                  40                  45              


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    50                  55                  60                  


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
65                  70                  75                  80  


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SMCY peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is S or A

<220>
<221>  X
<222>  (8)..(8)
<223>  X is R or Q

<400>  34

Ser Pro Xaa Val Asp Lys Ala Xaa Ala Glu Leu 
1               5                   10      


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta intracellular domain

<400>  35

Met Ala Met Val Lys Arg Lys Asp Ser Arg 
1               5                   10  


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta intracellular domain

<400>  36
atggccatgg tcaagagaaa ggattccaga                                        30


<210>  37
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular domain

<400>  37

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  38
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 intracellular domain

<400>  38
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  39
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  39

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  40
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  40
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag gccagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L1

<400>  41

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L2

<400>  42

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L3

<400>  43

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H1

<400>  44

Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile His 
1               5                   10          


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H2

<400>  45

Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly Lys 
        


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H3

<400>  46

Glu Glu Ile Thr Tyr Ala Met Asp Tyr 
1               5                   


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L1

<400>  47

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L2

<400>  48

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L3

<400>  49

Met Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H1

<400>  50

Ser Gly Tyr Thr Phe Thr Ser Tyr His Met His 
1               5                   10      


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H2

<400>  51

Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H3

<400>  52

Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  53
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  53

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  54
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  55
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  56
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  57
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  58
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Met Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys His Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  59
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  59

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Leu Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  60
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  60

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Asp Ser Val Ser Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Lys Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Pro 
225                 230                 235                 240 


Gly Thr Lys Val Asp Ile Lys 
                245         


<210>  61
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  61

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  62
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  63
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  63

Gln Val Thr Leu Lys Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Met Asp Thr Ser Phe 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  64
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 ScFv

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Met Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  65
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Pro Ser Gln Glu Gly Pro 
                645                 650                 655     


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            660                 665                 670 


<210>  66
<211>  3229
<212>  DNA
<213>  Homo sapiens

<400>  66
aaatgagttt taaaaaggct tgtccaggaa gcacatatgg gagctggtca ctctgcattt       60

tgggccctcc tggaggtgtt tagaccttcc gagagagaaa ctgagacaca tgagagggaa      120

gaaatgactc agtggtgaga ccctgtggag tcccacccac aaccagcaca ctgtgaccca      180

ctgcacaaac ctctagccca cagctcactt cctcctttaa gaagagaaga gaaaagagga      240

gaggagagga ggaacagaaa agaaaagaaa agaaaaagtg ggaaacaaat aatctaagaa      300

tgaggagaaa gcaagaagag tgaccccctt gtgggcactc cattggtttt atggcgcctc      360

tactttctgg agtttgtgta aaacaaaaat attatggtct ttgtgcacat ttacatcaag      420

ctcagcctgg gcggcacagc cagatgcgag atgcgtctct gctgatctga gtctgcctgc      480

agcatggacc tgggtcttcc ctgaagcatc tccagggctg gagggacgac tgccatgcac      540

cgagggctca tccatccaca gagcagggca gtgggaggag acgccatgac ccccatcctc      600

acggtcctga tctgtctcgg gctgagtctg ggcccccgga cccacgtgca ggcagggcac      660

ctccccaagc ccaccctctg ggctgaacca ggctctgtga tcacccaggg gagtcctgtg      720

accctcaggt gtcagggggg ccaggagacc caggagtacc gtctatatag agaaaagaaa      780

acagcaccct ggattacacg gatcccacag gagcttgtga agaagggcca gttccccatc      840

ccatccatca cctgggaaca cacagggcgg tatcgctgtt actatggtag cgacactgca      900

ggccgctcag agagcagtga ccccctggag ctggtggtga caggagccta catcaaaccc      960

accctctcag cccagcccag ccccgtggtg aactcaggag ggaatgtaac cctccagtgt     1020

gactcacagg tggcatttga tggcttcatt ctgtgtaagg aaggagaaga tgaacaccca     1080

caatgcctga actcccagcc ccatgcccgt gggtcgtccc gcgccatctt ctccgtgggc     1140

cccgtgagcc cgagtcgcag gtggtggtac aggtgctatg cttatgactc gaactctccc     1200

tatgagtggt ctctacccag tgatctcctg gagctcctgg tcctaggtgt ttctaagaag     1260

ccatcactct cagtgcagcc aggtcctatc gtggcccctg aggagaccct gactctgcag     1320

tgtggctctg atgctggcta caacagattt gttctgtata aggacgggga acgtgacttc     1380

cttcagctcg ctggcgcaca gccccaggct gggctctccc aggccaactt caccctgggc     1440

cctgtgagcc gctcctacgg gggccagtac agatgctacg gtgcacacaa cctctcctcc     1500

gagtggtcgg cccccagcga ccccctggac atcctgatcg caggacagtt ctatgacaga     1560

gtctccctct cggtgcagcc gggccccacg gtggcctcag gagagaacgt gaccctgctg     1620

tgtcagtcac agggatggat gcaaactttc cttctgacca aggagggggc agctgatgac     1680

ccatggcgtc taagatcaac gtaccaatct caaaaatacc aggctgaatt ccccatgggt     1740

cctgtgacct cagcccatgc ggggacctac aggtgctacg gctcacagag ctccaaaccc     1800

tacctgctga ctcaccccag tgaccccctg gagctcgtgg tctcaggacc gtctgggggc     1860

cccagctccc cgacaacagg ccccacctcc acatctggcc ctgaggacca gcccctcacc     1920

cccaccgggt cggatcccca gagtggtctg ggaaggcacc tgggggttgt gatcggcatc     1980

ttggtggccg tcatcctact gctcctcctc ctcctcctcc tcttcctcat cctccgacat     2040

cgacgtcagg gcaaacactg gacatcgacc cagagaaagg ctgatttcca acatcctgca     2100

ggggctgtgg ggccagagcc cacagacaga ggcctgcagt ggaggtccag cccagctgcc     2160

gatgcccagg aagaaaacct ctatgctgcc gtgaagcaca cacagcctga ggatggggtg     2220

gagatggaca ctcggagccc acacgatgaa gacccccagg cagtgacgta tgccgaggtg     2280

aaacactcca gacctaggag agaaatggcc tctcctcctt ccccactgtc tggggaattc     2340

ctggacacaa aggacagaca ggcggaagag gacaggcaga tggacactga ggctgctgca     2400

tctgaagccc cccaggatgt gacctacgcc cagctgcaca gcttgaccct cagacgggag     2460

gcaactgagc ctcctccatc ccaggaaggg ccctctccag ctgtgcccag catctacgcc     2520

actctggcca tccactagcc caggggggga cgcagacccc acactccatg gagtctggaa     2580

tgcatgggag ctgccccccc agtggacacc attggacccc acccagcctg gatctacccc     2640

aggagactct gggaactttt aggggtcact caattctgca gtataaataa ctaatgtctc     2700

tacaattttg aaataaagca acagacttct caataatcaa tgaagtagct gagaaaacta     2760

agtcagaaag tgcattaaac tgaatcacaa tgtaaatatt acacatcaag cgatgaaact     2820

ggaaaactac aagccacgaa tgaatgaatt aggaaagaaa aaaagtagga aatgaatgat     2880

cttggctttc ctataagaaa tttagggcag ggcacggtgg ctcacgcctg taattccagc     2940

actttgggag gccgaggcgg gcagatcacg agttcaggag atcgagacca tcttggccaa     3000

catggtgaaa ccctgtctct cctaaaaata caaaaattag ctggatgtgg tggcagtgcc     3060

tgtaatccca gctatttggg aggctgaggc aggagaatcg cttgaaccag ggagtcagag     3120

gtttcagtga gccaagatcg caccactgct ctccagcctg gcgacagagg gagactccat     3180

ctcaaattaa aaaaaaaaaa aaaaaagaaa gaaaaaaaaa aaaaaaaaa                 3229


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM

<400>  67

Asn Leu Tyr Ala Ala Val 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM

<400>  68

Val Thr Tyr Ala Glu Val 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM

<400>  69

Val Thr Tyr Ala Gln Leu 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM

<400>  70

Ser Ile Tyr Ala Thr Leu 
1               5       


<210>  71
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM 1-2

<400>  71

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val 
        35  


<210>  72
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM 2-3

<400>  72

Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
1               5                   10                  15      


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            20                  25                  30          


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        35                  40                  45              


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu 
    50                  55              


<210>  73
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM 3-4

<400>  73

Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
1               5                   10                  15      


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
            20                  25                  30          


Tyr Ala Thr Leu 
        35      


<210>  74
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM 1-3

<400>  74

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        35                  40                  45              


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
65                  70                  75                  80  


Asp Val Thr Tyr Ala Gln Leu 
                85          


<210>  75
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM 2-4

<400>  75

Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
1               5                   10                  15      


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            20                  25                  30          


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        35                  40                  45              


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    50                  55                  60                  


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
65                  70                  75                  80  


Val Pro Ser Ile Tyr Ala Thr Leu 
                85              


<210>  76
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM 1-4

<400>  76

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        35                  40                  45              


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
65                  70                  75                  80  


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
                85                  90                  95      


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
            100                 105                 110         


Ile Tyr Ala Thr Leu 
        115         


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D3D4 domain

<400>  77

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu 
            20  


<210>  78
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short hinge

<400>  78

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
        35                  40              


<210>  79
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge- transmembrane

<400>  79

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu 
                85      


<210>  80
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge-transmembrane-intracellular domain

<400>  80

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp 
            20                  25                  30          


Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val 
        35                  40                  45              


Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala 
    50                  55                  60                  


Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln 
65                  70                  75                  80  


Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp 
                85                  90                  95      


Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg 
            100                 105                 110         


Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr 
        115                 120                 125             


Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala 
    130                 135                 140                 


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro 
                165                 170                 175     


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            180                 185                 190 


<210>  81
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 intracellular domain

<400>  81

Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala 
1               5                   10                  15      


Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg 
            20                  25                  30          


Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn 
        35                  40                  45              


Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met 
    50                  55                  60                  


Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
65                  70                  75                  80  


Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
                85                  90                  95      


Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu 
            100                 105                 110         


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp 
        115                 120                 125             


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
    130                 135                 140                 


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
145                 150                 155                 160 


Tyr Ala Thr Leu Ala Ile His 
                165         


<210>  82
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge-transmemebrane-intracellular domain

<400>  82

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr 
                85                  90                  95      


Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly 
            100                 105                 110         


Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala 
        115                 120                 125             


Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro 
    130                 135                 140                 


Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro 
145                 150                 155                 160 


Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu 
                165                 170                 175     


Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys 
            180                 185                 190         


Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala 
        195                 200                 205             


Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr 
    210                 215                 220                 


Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser 
225                 230                 235                 240 


Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                245                 250             


<210>  83
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge-TM-intracellular domain

<400>  83

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile 
        35                  40                  45              


Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu 
    50                  55                  60                  


Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg 
65                  70                  75                  80  


Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr 
                85                  90                  95      


Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu 
            100                 105                 110         


Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val 
        115                 120                 125             


Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr 
    130                 135                 140                 


Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro 
145                 150                 155                 160 


Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala 
                165                 170                 175     


Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro 
            180                 185                 190         


Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu 
        195                 200                 205             


Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro 
    210                 215                 220                 


Ser Ile Tyr Ala Thr Leu Ala Ile His 
225                 230             


<210>  84
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  84

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    50                  55                  60              


<210>  85
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 transmembrane domain

<400>  85

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu 
            20              


<210>  86
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Asp Ile Val Met Thr Gln Ser Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 


Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr 
    210                 215                 220                 


Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  87
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  87
caggtgcagc tggtgcagtc tggggctgag gtggagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gtctggctgg      300

gactttgact actggggcca gggaaccctg gtcaccgtgt cctcaggcgg aggtggaagc      360

ggagggggag gatctggcgg cggaggaagc ggaggcgaca tcgtgatgac ccagtcttcc      420

tccctgtctg catctgtcgg agacagagtc accatcactt gccgggccag tcagagcatt      480

aggtactatt taagttggta tcagcagaaa ccaggaaaag cccctaagct cctgatctat      540

actgcatcca ttttacaaaa tggggtccca tcaaggttca gtggcagtgg atctgggaca      600

gatttcactc tcaccatcag cagcctgcaa cctgaggatt ttgcaactta ttactgcctc      660

cagacttaca ctactccgga ctttggccca gggaccaagg tggaaatcaa a               711


<210>  88
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Ala Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Arg Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Arg Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ala Ser Cys Gly Gly Asp Cys Tyr Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Glu Asn Val Asn Ile Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ser Ser Ser 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  89
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  89
caggtgcagc tggtgcagtc tggggctgag gtgagggcac ctggggcctc agtgaagatt       60

tcctgcaagg cttctggatt caccttcaga ggctactata tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatc atcaacccta gtggtggtag cagagcctac      180

gcacagaagt tccagggcag ggtcaccatg accagggaca cttccacgag cacagtctac      240

atggagctga gcagcctgag atctgacgac acggccatgt attactgtgc gagaaccgca      300

agttgtggtg gtgactgcta ctaccttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc tcccaccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtgagaa tgttaatatc tggttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctataagtca tccagtttag caagtggggt cccatcaagg      600

ttcagtggca gtggatctgg ggcagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagtat caaagttacc ccctcacttt cggcggaggg      720

accaaggtgg aaatcaaa                                                    738


<210>  90
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  91
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  91
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata ctcattcacc ggctacacca tgaactgggt gaggcaggcc      120

cctggacaaa gacttgagtg gatgggactt atcacccctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcag ggtcacaatc actagagaca cgtcagccag cacagcctac      240

atggagctct ccagcctgag atctgaagac actgcagtct attactgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc cagggaacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc cttcaagctt gtctgcatct gtaggagaca gggtcaccat cacttgcagt      480

gccagctcaa gtgtaagtta catgcactgg tatcagcaga aaccaggcaa ggcccctaag      540

agattgatct atgacacatc caaattagca agtggggtcc caagtcgctt cagtggcagt      600

ggatctggga ccgaattcac tctcaccatc agcagcttgc agcctgagga ttttgcaact      660

tattactgcc agcagtggag tggttaccct ctcacgttcg gtcaggggac aaagttggaa      720

atcaaa                                                                 726


<210>  92
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  92

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  93
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSLN binding domain

<400>  93
caggtgcagc tgcagcagtc tgggcctgag ctggagaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttctggata ctcattcacc ggctacacca tgaactgggt gaagcagagc      120

catggaaaaa gccttgagtg gattggactt atcacccctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcaa ggccacatta actgtagaca agtcatccag cacagcctac      240

atggacctcc tcagcctgac atctgaagac tctgcagtct atttctgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc cagggaacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catcgagctc      420

acccagtctc ctgcaatcat gtctgcatct ccaggagaga aggtcaccat gacttgcagt      480

gccagctcaa gtgtaagtta catgcactgg tatcagcaga aatcaggcac ctcccctaag      540

agatggatct atgacacatc caaattggca agtggggtcc caggtcgctt cagtggcagt      600

ggatctggga actcttactc tctcaccatc agcagcgtgg aggctgagga tgatgcaact      660

tattactgcc agcagtggag tggttaccct ctcacgttcg gtgctgggac aaagttggaa      720

atcaaa                                                                 726


<210>  94
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  94

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Asn Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro 
                165                 170                 175     


Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  95
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  95
caggtccagc tgcagcagtc tggggcagag cttgtgaggt cagggacctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactcctata tgcactggtt gaggcagggg      120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcaa ggccactttt actacagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtaa tgaagggaca      300

ccgacagggc catactattt tgactactgg ggtcaaggaa ccacagtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagaacgtt      420

ctcacccagt ctccagcaat catgtctgca tctccagggg agaaggtcac cataacctgc      480

agtgccagct caagtgtaag ttacatgcac tggttccagc agaagccagg cacttctccc      540

aaactctgga tttatagcac atccaacctg gcttctggag tccctgctcg cttcagtggc      600

agtggatctg ggacctctta ctctctcaca atcagccgaa tggaggctga agatgctgcc      660

acttattact gccagcaaag gagtagttac ccgctcacgt tcggtgctgg gaccaagctg      720

gagctgaaa                                                              729


<210>  96
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Leu Ala Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  97
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  97
caggtccagc tggtgcagtc tggggcagag gtgaagaaac caggggcctc agtcaaggtg       60

tcctgcaaag cttctggctt caacattaaa gactcctata tgcactgggt gaggcaggcg      120

cctggacagg gcctggagtg gatgggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcag ggtcactatg actacagaca catccacctc cacagcctac      240

atggagctca ggagcctgag atctgacgac actgccgtct attactgtaa tgaagggaca      300

ccgacagggc catactattt tgactactgg ggtcaaggaa ccacagtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagatcgtt      420

ctcacccagt ctccagcaac cttgtctctg tctccagggg agagggccac cctaagctgc      480

agtgccagct caagtgtaag ttacatgcac tggtaccagc agaagccagg ccttgctccc      540

agactcctga tttatagcac atccaacctg gcttctggaa tccctgatcg cttcagtggc      600

agtggatctg ggaccgattt cactctcaca atcagccgac tggagcctga agatttcgcc      660

gtttattact gccagcaaag gagtagttac ccgctcacgt tcggtcaggg gaccaagctg      720

gagatcaaa                                                              729


<210>  98
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  98

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Glu Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val 
    130                 135                 140                 


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Ser Ser Tyr Ala Ser Trp Tyr Arg Gln Arg Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile 
        195                 200                 205             


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Trp Asn Ser Ser 
    210                 215                 220                 


Tyr Ala Trp Leu Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  99
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  99
gaggtgcagc tggcggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agcgatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc aaagtctaat      300

gagtttcttt ttgactactg gggccaaggt accctggtca ccgtgtcgag tggcggaggt      360

ggaagcggag ggggaggatc tggcggcgga ggaagcggag gctcttctga gctgactcag      420

gaccctgctg tgtctgtggc cttgggacag acagtcagga tcacatgcca aggagacagc      480

ctcagaagct cttatgcaag ctggtaccgg cagaggccag gacaggcccc tgtacttgtc      540

atctatggta aaaacaaccg gccctcaggg atcccagacc gattctctgg ctccagctca      600

ggaaacacag cttccttgac catcactggg gctcaggcgg aagatgaggc tgactattac      660

tggaactcca gctacgcttg gctgccctac gtggtattcg gcggagggac caagctgacc      720

gtcctaggt                                                              729


<210>  100
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  100

Gln Val Gln Leu Glu Gln Ser Gly Ala Gly Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Asn Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Met Ser Val Ser Val Gly Asp Arg Val Asn Ile Ala Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Pro Tyr Met His Trp Leu Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ser Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  101
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA binding domain

<400>  101
caggtccagc tggagcagtc tggggcaggg gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caacattaaa gactcctata tgcactggtt gaggcagggg      120

cctggacagc gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcaa ggccactttt actacagaca catccgccaa cacagcctac      240

ctggggctca gcagcctgag acctgaggac actgccgtct attactgtaa tgaagggaca      300

ccgacagggc catactattt tgactactgg ggtcaaggaa ccctagtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagaacgtt      420

ctcacccagt ctccaagctc tatgtctgta tctgtcgggg acagggtcaa catcgcctgc      480

agtgccagct caagtgtacc ttacatgcac tggctccagc agaagccagg caaatctccc      540

aaactcctga tttatctcac atccaacctg gcttctggag tccctagccg cttcagtggc      600

agtggatctg ggaccgatta ctctctcaca atcagctcag tgcagcctga agatgctgcc      660

acttattact gccagcaaag gagtagttac ccgctcacgt tcggtggtgg gaccaagctg      720

gagatcaaa                                                              729


<210>  102
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  102

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Val 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
            180                 185                 190         


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Glu 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  103
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  103
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatgggatg atggaagtta taaatactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatggt      300

attactatgg ttcggggagt tatgaaggac tactttgact actggggcca gggaaccctg      360

gtcaccgtct cctcaggcgg aggtggaagc ggagggggag gatctggcgg cggaggaagc      420

ggaggcgcca tccagttgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      480

gtcaccatca cttgccgggc aagtcaggac attagcagtg ctttagtctg gtatcagcag      540

aaaccaggga aagctcctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc      600

ccatcaaggt tcagcggcag tgaatctggg acagatttca ctctcaccat cagcagcctg      660

cagcctgaag attttgcaac ttattactgt caacagttta atagttaccc gctcactttc      720

ggcggaggga ccaaggtgga gatcaaa                                          747


<210>  104
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  104

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp 
                165                 170                 175     


Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly 
    210                 215                 220                 


Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  105
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  105
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc agtgctttag tctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtgaatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa aggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gccaggtgca gctggtggag tctgggggag gcgtggtcca gcctgggagg      420

tccctgagac tctcctgtgc agcgtctgga ttcaccttca gtacctatgg catgcactgg      480

gtccgccagg ctccaggcaa ggggctggag tgggtggcag ttatatggga tgatggaagt      540

tataaatact atggagactc cgtgaagggc cgattcacca tctccagaga caattccaag      600

aacacgctgt atctgcaaat gaacagcctg agagccgagg acacggctgt gtattactgt      660

gcgagagatg gtattactat ggttcgggga gttatgaagg actactttga ctactggggc      720

cagggaaccc tggtcaccgt ctcctca                                          747


<210>  106
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  106

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  107
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  107
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cctctgggta taccttcaca gaatatccaa tacactgggt gaagcaggct      120

ccaggaaagg gtttcaagtg gatgggcatg atatacaccg acattggaaa gccaacatat      180

gctgaagagt tcaagggacg gtttgccttc tctttggaga cctctgccag cactgcctat      240

ttgcagatca acaacctcaa gaatgaggac acggctacat atttctgtgt aagagatcga      300

tatgattccc tctttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tgtgatgacc      420

caaactccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      480

agtcagagcc ttgtacacag taatggaaac acctatttac attggtacct gcagaagcca      540

ggccagtctc caaagctcct gatctacaaa gtttccaacc gattttctgg ggtcccagac      600

aggttcagtg gcagtggatc agggacagat ttcacactca agatcagcag agtggaggct      660

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttccgtggac gttcggtgga      720

ggcaccaagc tggaaatcaa a                                                741


<210>  108
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  108

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu 
145                 150                 155                 160 


Tyr Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp 
                165                 170                 175     


Met Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu 
            180                 185                 190         


Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Leu Thr Val Ser Ser 
                245         


<210>  109
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  109
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag atccagttgg tgcagtctgg acctgagctg      420

aagaagcctg gagagacagt caagatctcc tgcaaggcct ctgggtatac cttcacagaa      480

tatccaatac actgggtgaa gcaggctcca ggaaagggtt tcaagtggat gggcatgata      540

tacaccgaca ttggaaagcc aacatatgct gaagagttca agggacggtt tgccttctct      600

ttggagacct ctgccagcac tgcctatttg cagatcaaca acctcaagaa tgaggacacg      660

gctacatatt tctgtgtaag agatcgatat gattccctct ttgactactg gggccaaggc      720

accactctca cagtctcctc a                                                741


<210>  110
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  110

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Val Val Met Thr Gln 
    130                 135                 140                 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
                165                 170                 175     


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Leu Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  111
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  111
gaaatgcagc tggtggagtc tgggggaggc ttcgtgaagc ctggagggtc cctgaaactc       60

tcatgtgcag cctctggatt cgctttcagt cactatgaca tgtcttgggt tcgccagact      120

ccgaagcaga ggctggagtg ggtcgcatac attgctagtg gtggtgatat cacctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgcccagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt tttactgttc acgatcctcc      300

tatggtaaca acggagatgc cctggacttc tggggtcaag gtacctcagt caccgtctcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgatgtt      420

gtgatgaccc aaactccact ctccctgcct gtcagtcttg gagatcaagc ctccatctct      480

tgcagatcta gtcagagcct tgttcacagt aatggaaaca cctatttaca ttggtacctg      540

cagaagccag gccagtctcc aaagctcctg atctacaaag tttccaaccg attttctggg      600

gtcccagaca ggttcagtgg cagtggatca gggacagatt tcacactcaa gatcagcaga      660

gtggaggctg aggatctggg agtttatttc tgctctcaaa gtacacatgt tctcacgttc      720

ggctcgggga caaagttgga aataaaa                                          747


<210>  112
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  112

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
145                 150                 155                 160 


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
                165                 170                 175     


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 


<210>  113
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  113
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgtt cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttctc      300

acgttcggct cggggacaaa gttggaaata aaaggcggag gtggaagcgg agggggagga      360

tctggcggcg gaggaagcgg aggcgaaatg cagctggtgg agtctggggg aggcttcgtg      420

aagcctggag ggtccctgaa actctcatgt gcagcctctg gattcgcttt cagtcactat      480

gacatgtctt gggttcgcca gactccgaag cagaggctgg agtgggtcgc atacattgct      540

agtggtggtg atatcaccta ctatgcagac actgtgaagg gccgattcac catctccaga      600

gacaatgccc agaacaccct gtacctgcaa atgagcagtc tgaagtctga ggacacagcc      660

atgttttact gttcacgatc ctcctatggt aacaacggag atgccctgga cttctggggt      720

caaggtacct cagtcaccgt ctcctca                                          747


<210>  114
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  114

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Leu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr 
                165                 170                 175     


Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
            180                 185                 190         


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  115
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  115
caggtgcagc tgaagcagtc cggccccggc ctggtgcagc cctcccagtc cctgtccatc       60

acctgcaccg tgtccggctt ctccctgacc aactacggcg tgcactgggt gcggcagtcc      120

cccggcaagg gcctggagtg gctgggcgtg atctggtccg gcggcaacac cgactacaac      180

acccccttca cctcccggct gtccatcaac aaggacaact ccaagtccca ggtgttcttc      240

aagatgaact ccctgcagtc caacgacacc gccatctact actgcgcccg ggccctgacc      300

tactacgact acgagttcgc ctactggggc cagggcaccc tggtgaccgt gtccgccggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catcctgctg      420

acccagtccc ccgtgatcct gtccgtgtcc cccggcgagc gggtgtcctt ctcctgccgg      480

gcctcccagt ccatcggcac caacatccac tggtaccagc agcggaccaa cggctccccc      540

cggctgctga tcaagtacgc ctccgagtcc atctccggca tcccctcccg gttctccggc      600

tccggctccg gcaccgactt caccctgtcc atcaactccg tggagtccga ggacatcgcc      660

gactactact gccagcagaa caacaactgg cccaccacct tcggcgccgg caccaagctg      720

gagctgaag                                                              729


<210>  116
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  116

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser His Ile Phe Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  117
<211>  731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  117
aggtgcagct ggtgcagtcc ggcgccgagg tgaagaagcc cggcgcctcc gtgaaggtgt       60

cctgcaaggc ctccggctac accttcacct cccactggat gcactgggtg cggcaggccc      120

ccggccaggg cctggagtgg atcggcgagt tcaacccctc caacggccgg accaactaca      180

acgagaagtt caagtccaag gccaccatga ccgtggacac ctccaccaac accgcctaca      240

tggagctgtc ctccctgcgg tccgaggaca ccgccgtgta ctactgcgcc tcccgggact      300

acgactacga cggccggtac ttcgactact ggggccaggg caccctggtg accgtgtcct      360

ccggcggagg tggaagcgga gggggaggat ctggcggcgg aggaagcgga ggcgacatcc      420

agatgaccca gtccccctcc tccctgtccg cctccgtggg cgaccgggtg accatcacct      480

gctccgcctc ctcctccgtg acctacatgt actggtacca gcagaagccc ggcaaggccc      540

ccaagctgct gatctacgac acctccaacc tggcctccgg cgtgccctcc cggttctccg      600

gctccggctc cggcaccgac tacaccttca ccatctcctc cctgcagccc gaggacatcg      660

ccacctacta ctgccagcag tggtcctccc acatcttcac cttcggccag ggcaccaagg      720

tggagatcaa g                                                           731


<210>  118
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  119
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  119
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctccgagac cctgtccctg       60

acctgcaccg tgtccggcgg ctccgtgtcc tccggcgact actactggac ctggatccgg      120

cagtcccccg gcaagggcct ggagtggatc ggccacatct actactccgg caacaccaac      180

tacaacccct ccctgaagtc ccggctgacc atctccatcg acacctccaa gacccagttc      240

tccctgaagc tgtcctccgt gaccgccgcc gacaccgcca tctactactg cgtgcgggac      300

cgggtgaccg gcgccttcga catctggggc cagggcacca tggtgaccgt gtcctccggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtccc cctcctccct gtccgcctcc gtgggcgacc gggtgaccat cacctgccag      480

gcctcccagg acatctccaa ctacctgaac tggtaccagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc ctccaacctg gagaccggcg tgccctcccg gttctccggc      600

tccggctccg gcaccgactt caccttcacc atctcctccc tgcagcccga ggacatcgcc      660

acctacttct gccagcactt cgaccacctg cccctggcct tcggcggcgg caccaaggtg      720

gagatcaag                                                              729


<210>  120
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  121

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  122
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH

<400>  122

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  123
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  123

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  124
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH

<400>  124

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  125
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  125

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  126
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGR VH

<400>  126

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  127
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  127

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  128
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH

<400>  128

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  129
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Ile Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  130
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  131
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H1

<400>  132

Thr Tyr Gly Met His 
1               5   


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H1

<400>  133

Glu Tyr Pro Ile His 
1               5   


<210>  134
<211>  5
<212>  PRT
<213>  Artificial SEquence

<220>
<223>  EGFR CDR-H1

<400>  134

His Tyr Asp Met Ser 
1               5   


<210>  135
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H1

<400>  135

Asn Tyr Gly Val His 
1               5   


<210>  136
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H1

<400>  136

Ser His Trp Met His 
1               5   


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H1

<400>  137

Ser Gly Asp Tyr Tyr Trp Thr 
1               5           


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H2

<400>  138

Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H2

<400>  139

Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H2

<400>  140

Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H2

<400>  141

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
1               5                   10                  15      


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H2

<400>  142

Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H2

<400>  143

His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequnece

<220>
<223>  EGFR CDR-H3

<400>  144

Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H3

<400>  145

Asp Arg Tyr Asp Ser Leu Phe Asp Tyr 
1               5                   


<210>  146
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H3

<400>  146

Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe 
1               5                   10          


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H3

<400>  147

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10      


<210>  148
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H3

<400>  148

Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr 
1               5                   10          


<210>  149
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-H3

<400>  149

Asp Arg Val Thr Gly Ala Phe Asp Ile 
1               5                   


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L1

<400>  150

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Val 
1               5                   10      


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L1

<400>  151

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFRR CDR-L1

<400>  152

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L1

<400>  153

Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
1               5                   10      


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L1

<400>  154

Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr 
1               5                   10  


<210>  155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L1

<400>  155

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  156
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L2

<400>  156

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L2

<400>  157

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L2

<400>  158

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L2

<400>  159

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L2

<400>  160

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L3

<400>  161

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L3

<400>  162

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L3

<400>  163

Ser Gln Ser Thr His Val Leu Thr 
1               5               


<210>  164
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L3

<400>  164

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L3

<400>  165

Gln Gln Trp Ser Ser His Ile Phe Thr 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR-L3

<400>  166

Gln His Phe Asp His Leu Pro Leu Ala 
1               5                   


<210>  167
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  167

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ile Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Lys Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Ile Cys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg 
            180                 185                 190         


Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Arg 
                245     


<210>  168
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  168
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccctg       60

acctgcacag tctctggttt ctcattaact agttatggcg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagact gagcatcagg aaggacaact ccaagagcca agtcttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cagcatcgtg      420

atgacccaga ctccaaaatt cctgcttgtg tctgcgggag acagagtcac catcacttgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc agcagaaacc agggcaatct      540

cctatctgtc tcctgatcta ctatgcatct aatcggtata caggggtccc tgataggttc      600

accggaagtg gatatgggac agatttcact ttcaccatca gcaccgtgca ggctgaagat      660

cttgcagtat atttctgtca acaggattat agtagtcctc cgtggacttt cggcggaggg      720

accaagttgg agatcaga                                                    738


<210>  169
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  169

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  170
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  170
caggtgcagc tgcaggagtc cggacctggc ctagtgaagc cctcacagac cctgtccctg       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactggat tagacagcct      120

ccaggaaagg gtctggagtg gattggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagagt gaccatcagc gtggacacct ccaagaacca attctccctt      240

aaactgagca gtgtgacagc tgccgacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatcgtg      420

atgacccaga gtccagattc cctggctgtg tctctgggag agagagccac catcaattgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc agcagaaacc agggcaacct      540

cctaaactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactctc accatcagca gcctgcaggc tgaagatgtt      660

gcagtatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  171
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  171

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  172
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  172
gaggtgcagc tgctggagtc cggaggtggc ctagtgcagc ccggagggag cctgcgcctg       60

agctgcgcag cctctggttt ctcattaact agctatggtg tacactgggt tagacaggct      120

ccaggaaagg gtctggagtg ggttagcgtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagatt taccatcagc cgggacaact ccaagaacac actctacctt      240

caaatgaaca gtttgagagc tgaagacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gtccaagctc cctgtctgcg tctgtgggag acagagtcac catcacttgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc agcagaaacc agggaaagct      540

cctaaactcc tgatctacta tgcatctaat cggtatacag gggtccctag taggttcagc      600

ggaagtggat ctgggacaga tttcactttc accatcagca gcctgcagcc tgaagatatt      660

gcaacatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  173
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  173

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  174
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  174
caggtgcagc tgcaggagtc cggacctggc ctagtgaagc cctcagaaac cctgtccctg       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactggat tagacagcct      120

ccaggaaagg gtctggagtg gattggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagagt gaccatcagc agggacacct ccaagaacca attctccctt      240

aaactgagca gtgtgacagc tgccgacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatcgtg      420

atgacccaga ctccactttc cctgtctgtg actccgggac agccagccag catcagttgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc tgcagaaacc agggcaatct      540

cctcaactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactttg aagatcagca gggtggaggc tgaagatgtt      660

ggagtatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  175
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  175

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Asn Asp Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  176
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  176
caggtgcagc tggtggagtc cggaggtggc gtagtgcagc ccggaaggag cctgcgcctg       60

agctgcgcag tctctggttt ctcattaact agctatggta tgcactgggt tagacaggct      120

ccaggaaagg gtctggagtg ggttgcagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagatt taccatcagc cgggacaact ccaagaacac actctacctt      240

caaatgaaca gtttgagagc tgaagacaca gccgtatact actgtgccaa aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagatcgtg      420

ctgacccaga gtccagctac cctgtctctg tctccgggag agagagccac cctcagttgc      480

agggcgagtc agtctgtgag caacgaccta gcttggtatc agcagaaacc agggcaagct      540

cctagactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactctc accatcagca gcctggagcc tgaagatttt      660

gcagtatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg ccaagggacc      720

aaggtggaga tcaaa                                                       735


<210>  177
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  177

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Gln Ala Ser Gln Ser Val Ser Asn Asp Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  178
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pan-HLA ScFv

<400>  178
caggtgcagc tggtggagtc cggaggtggc gtagtgcagc ccggaaggag cctgcgcctg       60

agctgcgcag tctctggttt ctcattaact agctatggta tgcactgggt tagacaggct      120

ccaggaaagg gtctggagtg ggttgcagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagatt taccatcagc cgggacaact ccaagaacac actctacctt      240

caaatgaaca gtttgagagc tgaagacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gtccaagctc cctgtctgcg tctgtgggag acagagtcac catcacttgc      480

caggcgagtc agtctgtgag caacgaccta aattggtatc agcagaaacc agggaaagct      540

cctaaactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactttc accatcagca gcctgcagcc tgaagatatt      660

gcaacatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  179
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  179
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agtagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cggacgtccg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag gtccagctgc agcagtctgg acctgagctg      420

gtgaagcctg gggcttcagt gaggatatcc tgcaaggctt ctggctacac cttcacaagt      480

taccatatac attgggtgaa gcagaggcct ggacagggac ttgagtggat tggatggatt      540

tatcctggaa atgttaatac tgagtacaat gagaagttca agggcaaggc cacactgact      600

gcagacaaat cgtccagcac agcctacatg cacctcagca gcctgacctc tgaggactct      660

gcggtctatt tctgtgccag agaggagatt acctatgcta tggactactg gggtcaagga      720

acctcagtca ccgtgtcctc a                                                741


<210>  180
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  180
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat tgtattgacc      420

cagagcccag gcaccctgag cctctctcca ggagagcggg ccaccctcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtcaagccc caagattgct catctacaaa gtctctaaca gatttagtgg tattccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctccag gctcgagcca      660

gaagatttcg ccgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  181
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  181
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tgtaatgacc      420

cagaccccac tcagcctgcc cgtcactcca ggagagccgg ccagcatcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatct gcagaaacca      540

ggtcaatccc cacaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctccag ggtcgaggca      660

gaagatgtcg gcgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  182
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  182
gaggtgcagc tggtggagtc tgggggtggg ctggtgaagc ctgggggctc actgaggctt       60

tcctgcgcgg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggaaaag ggcttgagtg ggtgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcag attcaccatt agcagggacg attccaagaa cacactctac      240

ctgcagatga acagcctgaa aactgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccagcctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccaagc      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctcctc tctccagcca      660

gaagatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  183
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  183
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggacg aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagcc      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  184
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  184
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tgcattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatac atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccctt accgcggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt atttctgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacgt tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagctcc      480

agtcagagta ttgtacacag taatgggaac acctatatgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgtcatcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  185
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  185
caggtgcagc tgcagcagtc tgggcctgag ctggtgaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggata caccttcact agctatcata tccagtgggt gaagcagagg      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggtag tacacagtat      180

aatgagaagt tcaagggcaa aaccaccctt accgcggaca aatcctccag cacagcctac      240

atgttgctga gcagcctgac ctctgaagac tctgctatct atttctgtgc gagggagggg      300

acctactacg ctatggacta ctggggccag ggaacctcag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tttgatgacc      420

cagactccac tctccctgcc tgtctctctt ggagaccaag tctccatctc ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttag aatggtatct gcagaaacca      540

ggtcagtctc caaagttgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctcgag agtggaggct      660

gaggatctgg gagtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtgga      720

ggtactaaac tggaaatcaa a                                                741


<210>  186
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  186
cagctgcagc tgcaggagtc tgggcccggg ctggtgaagc cttcggaaac gctgagcctc       60

acctgcacgg tttctggata caccttcacc agctatcata tccagtggat ccgacagccc      120

cctggaaaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agccacgatt agcgtggaca catccaagaa ccaattctcc      240

ctgaacctgg acagcgtgag tgctgcggac acggccattt attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggcaaa gggagcacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccaa gctccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccttca cgattagcag cttgcagccc      660

gaagacatcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggccg      720

ggcacgaaag tggatattaa g                                                741


<210>  187
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  187
gaggtgcagc tggtgcagtc tggggccgag ctgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt aaaacaggcc      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agccacgctt accgtggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccat ccaccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagcag cttgcagccc      660

gatgacttcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggcag      720

ggcacgaaag tggaagttaa g                                                741


<210>  188
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  188
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctacaag gtgagcaacc ggttctccgg catccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  189
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  189
caggtgaccc tgaagcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcacgg cttctggata caccttcacc agctatcatg tcagctgggt acgacaggcc      120

cctggacaag ggcttgagtg gttgggaagg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt accgcggaca aatccatgga cacatccttc      240

atggagctga ccagcctgac atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacct ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg cgtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctccaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgccaacag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  190
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 antigen binding domain

<400>  190
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tgcactgggt acgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt acccgggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat cgtcatgacc      420

cagaccccac tgtccctgcc tgtgaccccg ggcgagcccg cgagcatcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg actggtacct gcagaagccc      540

gggcagtccc cgcaactgct catctacaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca agattagccg cgtggaggcc      660

gaagacgtcg gcgtgtacta ctgcatgcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1 variant H peptide

<400>  191

Val Leu His Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  192
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A self cleaving peptide

<400>  192

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  193
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR alpha and beta

<400>  193

Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Arg 
            100                 105                 110         


Ser Val Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Thr Ser Leu Leu Cys 
    290                 295                 300                 


Trp Met Ala Leu Cys Leu Leu Gly Ala Asp His Ala Asp Thr Gly Val 
305                 310                 315                 320 


Ser Gln Asn Pro Arg His Lys Ile Thr Lys Arg Gly Gln Asn Val Thr 
                325                 330                 335     


Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu 
        355                 360                 365             


Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg Phe Ser Ala Glu 
    370                 375                 380                 


Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln Arg Thr Glu Gln 
385                 390                 395                 400 


Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Ile Asp Ser Phe Asn 
                405                 410                 415     


Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu 
            420                 425                 430         


Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
        435                 440                 445             


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
    450                 455                 460                 


Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
465                 470                 475                 480 


Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
                485                 490                 495     


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            500                 505                 510         


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        515                 520                 525             


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
    530                 535                 540                 


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
545                 550                 555                 560 


Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                565                 570                 575     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            580                 585                 590         


Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
        595                 600                 605             


<210>  194
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-1(H) TCR alpha and beta

<400>  194
atggtgaaga tccggcaatt tttgttggct attttgtggc ttcagctaag ctgtgtaagt       60

gccgccaaaa atgaagtgga gcagagtcct cagaacctga ctgcccagga aggagaattt      120

atcacaatca actgcagtta ctcggtagga ataagtgcct tacactggct gcaacagcat      180

ccaggaggag gcattgtttc cttgtttatg ctgagctcag ggaagaagaa gcatggaaga      240

ttaattgcca caataaacat acaggaaaag cacagctccc tgcacatcac agcctcccat      300

cccagagact ctgccgtcta catctgtgct gtcagaagcg tgtccggggc cggctcctac      360

cagctcacct ttgggaaggg gaccaaatta tcagtcattc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaatgtgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagcggatc cggagccacc      840

aacttcagcc tgctgaagca ggccggcgac gtggaggaga accccggccc catgggcacc      900

agcctcctct gctggatggc cctgtgtctc ctgggggcag atcacgcaga tactggagtc      960

tcccagaacc ccagacacaa gatcacaaag aggggacaga atgtaacttt caggtgtgat     1020

ccaatttctg aacacaaccg cctttattgg taccgacaga ccctggggca gggcccagag     1080

tttctgactt acttccagaa tgaagctcaa ctagaaaaat caaggctgct cagtgatcgg     1140

ttctctgcag agaggcctaa gggatctttc tccaccttgg agatccagcg cacagagcag     1200

ggggactcgg ccatgtatct ctgtgccagc agcatcgact ccttcaacga gcagttcttc     1260

gggccgggca ccaggctcac ggtcctcgag gacctgaaaa acgtgttccc acccgaggtc     1320

gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc     1380

ctggccacag gcttctaccc cgaccacgtg gagctgagct ggtgggtgaa tgggaaggag     1440

gtgcacagtg gggtctgcac agacccgcag cccctcaagg agcagcccgc cctcaatgac     1500

tccagatact gcctgagcag ccgcctgagg gtgtcggcca ccttctggca gaacccccgc     1560

aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag     1620

gatagggcca aacctgtcac ccagatcgtc agcgccgagg cctggggtag agcagactgt     1680

ggcttcacct ccgagtctta ccagcaaggg gtcctgtctg ccaccatcct ctatgagatc     1740

ttgctaggga aggccacctt gtatgccgtg ctggtcagtg ccctcgtgct gatggccatg     1800

gtcaagagaa aggattccag aggctag                                         1827


<210>  195
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ftcr alpha LIR1 HA-1H

<400>  195

Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Arg 
            100                 105                 110         


Ser Val Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Val Ile Gly Ile Leu 
                245                 250                 255     


Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile 
            260                 265                 270         


Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
        275                 280                 285             


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
    290                 295                 300                 


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
305                 310                 315                 320 


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
                325                 330                 335     


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            340                 345                 350         


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        355                 360                 365             


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    370                 375                 380                 


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
385                 390                 395                 400 


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
                405                 410                 415     


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
            420                 425                 430         


Ile Tyr Ala Thr Leu Ala Ile His 
        435                 440 


<210>  196
<211>  1279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ftcr alpha LIR1 HA-1H

<400>  196
atggtgaaga tccggcaatt tttgttggct attttgtggc ttcagctaag ctgtgtaagt       60

gccgccaaaa atgaagtgga gcagagtcct cagaacctga ctgcccagga aggagaattt      120

atcacaatca actgcagtta ctcggtagga ataagtgcct tacactggct gcaacagcat      180

ccaggaggag gcattgtttc cttgtttatg ctgagctcag ggaagaagaa gcatggaaga      240

ttaattgcca caataaacat acaggaaaag cacagctccc tgcacatcac agcctcccat      300

cccagagact ctgccgtcta catctgtgct gtcagaagcg tgtccggggc cggctcctac      360

cagctcacct ttgggaaggg gaccaaatta tcagtcattc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaatgtgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gttgtgatcg gcatcttggt ggccgtcatc      780

ctactgctcc tcctcctcct cctcctcttc ctcatcctcc gacatcgacg tcagggcaaa      840

cactggacat cgacccagag aaaggctgat ttccaacatc ctgcaggggc tgtggggcca      900

gagcccacag acagaggcct gcagtggagg tccagcccag ctgccgatgc ccaggaagaa      960

aacctctatg ctgccgtgaa gcacacacag cctgaggatg gggtggagat ggacactcgg     1020

agcccacacg atgaagaccc ccaggcagtg acgtatgccg aggtgaaaca ctccagacct     1080

aggagagaaa tggcctctcc tccttcccca ctgtctgggg aattcctgga cacaaaggac     1140

agacaggcgg aagaggacag gcagatggac actgaggctg ctgcatctga agccccccag     1200

gatgtgacct acgcccagct gcacagcttg accctcagac gggaggcaac tgagcctcct     1260

ccatcccagg aagggccct                                                  1279


<210>  197
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ftcr beta LIR1 HA-1H

<400>  197

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Ile Asp Ser Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu 
        275                 280                 285             


Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln 
    290                 295                 300                 


Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro 
305                 310                 315                 320 


Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg 
                325                 330                 335     


Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val 
            340                 345                 350         


Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro 
        355                 360                 365             


His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser 
    370                 375                 380                 


Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu 
385                 390                 395                 400 


Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp 
                405                 410                 415     


Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln 
            420                 425                 430         


Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser 
        435                 440                 445             


Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala 
    450                 455                 460                 


Ile His 
465     


<210>  198
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ftcr beta LIR1 HA-1H

<400>  198
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat       60

actggagtct cccagaaccc cagacacaag atcacaaaga ggggacagaa tgtaactttc      120

aggtgtgatc caatttctga acacaaccgc ctttattggt accgacagac cctggggcag      180

ggcccagagt ttctgactta cttccagaat gaagctcaac tagaaaaatc aaggctgctc      240

agtgatcggt tctctgcaga gaggcctaag ggatctttct ccaccttgga gatccagcgc      300

acagagcagg gggactcggc catgtatctc tgtgccagca gcatcgactc cttcaacgag      360

cagttcttcg ggccgggcac caggctcacg gtcctcgagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgt tgtgatcggc      840

atcttggtgg ccgtcatcct actgctcctc ctcctcctcc tcctcttcct catcctccga      900

catcgacgtc agggcaaaca ctggacatcg acccagagaa aggctgattt ccaacatcct      960

gcaggggctg tggggccaga gcccacagac agaggcctgc agtggaggtc cagcccagct     1020

gccgatgccc aggaagaaaa cctctatgct gccgtgaagc acacacagcc tgaggatggg     1080

gtggagatgg acactcggag cccacacgat gaagaccccc aggcagtgac gtatgccgag     1140

gtgaaacact ccagacctag gagagaaatg gcctctcctc cttccccact gtctggggaa     1200

ttcctggaca caaaggacag acaggcggaa gaggacaggc agatggacac tgaggctgct     1260

gcatctgaag ccccccagga tgtgacctac gcccagctgc acagcttgac cctcagacgg     1320

gaggcaactg agcctcctcc atcccaggaa gggccctctc cagctgtgcc cagcatctac     1380

gccactctgg ccatccacta g                                               1401


<210>  199
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR alpha

<400>  199

Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Arg 
            100                 105                 110         


Ser Val Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
                245                 250 


<210>  200
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR beta

<400>  200

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Ile Asp Ser Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser 
        275     


<210>  201
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR alpha

<400>  201
atggtgaaga tccggcaatt tttgttggct attttgtggc ttcagctaag ctgtgtaagt       60

gccgccaaaa atgaagtgga gcagagtcct cagaacctga ctgcccagga aggagaattt      120

atcacaatca actgcagtta ctcggtagga ataagtgcct tacactggct gcaacagcat      180

ccaggaggag gcattgtttc cttgtttatg ctgagctcag ggaagaagaa gcatggaaga      240

ttaattgcca caataaacat acaggaaaag cacagctccc tgcacatcac agcctcccat      300

cccagagact ctgccgtcta catctgtgct gtcagaagcg tgtccggggc cggctcctac      360

cagctcacct ttgggaaggg gaccaaatta tcagtcattc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaatgtgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca                                       750


<210>  202
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR beta

<400>  202
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat       60

actggagtct cccagaaccc cagacacaag atcacaaaga ggggacagaa tgtaactttc      120

aggtgtgatc caatttctga acacaaccgc ctttattggt accgacagac cctggggcag      180

ggcccagagt ttctgactta cttccagaat gaagctcaac tagaaaaatc aaggctgctc      240

agtgatcggt tctctgcaga gaggcctaag ggatctttct ccaccttgga gatccagcgc      300

acagagcagg gggactcggc catgtatctc tgtgccagca gcatcgactc cttcaacgag      360

cagttcttcg ggccgggcac caggctcacg gtcctcgagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtct                   828


<210>  203
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO CDR

<400>  203

Cys Ala Ser Ser Leu Gly Leu Gly Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  204
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO CDR

<400>  204

Cys Ala Ser Ser Leu Gly Gly Pro Arg Gly Leu Ala Gly Leu Arg Gly 
1               5                   10                  15      


Asp Glu Gln Phe 
            20  


<210>  205
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO CDR

<400>  205

Cys Ala Ser Ser Leu Arg Arg Asp Asn Glu Gln Phe 
1               5                   10          


<210>  206
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 CDR

<400>  206

Cys Ala Ser Ser Leu Glu Val Leu Leu Gly Ala Asp Phe Pro Asp Thr 
1               5                   10                  15      


Gln Tyr Phe 
            


<210>  207
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 CDR

<400>  207

Cys Ala Ser Ser Phe Pro Ala Gly His Gly Ala Asp Leu Asp Asn Glu 
1               5                   10                  15      


Gln Phe 
        


<210>  208
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 CDR

<400>  208

Cys Ala Ser Ser Glu Ile Thr Gly Arg Ile Gly Glu Gln Phe 
1               5                   10                  


<210>  209
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 CDR

<400>  209

Cys Ala Ser Ser Leu Gly Gly Asp Glu Leu Gly Ala Asp Gly Asn Glu 
1               5                   10                  15      


Gln Phe 
        


<210>  210
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 ScFv

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  211
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 ScFv

<400>  211
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tca                                                                    723


<210>  212
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 antigen binding domain

<400>  212

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Phe Gly Asp Trp Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Phe Val Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  213
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 antigen binding domain

<400>  213
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagcgacac cctgagcctg       60

acctgcgccg tgtccggcta cagcatcagc agcagcaatt ggtggggctg gatcagacag      120

ccccctggca agggcctgga atggatcggc tacatctact acagcggcag cacctactac      180

aaccccagcc tgaagtccag agtgaccatg agcgtggaca ccagcaagaa ccagttcagc      240

ctgaagctga gcagcgtgac cgccgtcgat accgctgtgt attactgtgc gagaataccc      300

tttggggatt ggtggtactt cgatctctgg ggccgtggca ccctggtcac tgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagcag cctgagcgcc agcgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatcag cagctacctg aactggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacgc cgccagctcc ctgcagagcg gcgtgccaag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gagttacagt ttcgttctca ctttcggcgg agggaccaag      720

gtggagatca aa                                                          732


<210>  214
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 antigen binding domain

<400>  214

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Tyr Ser Ser Ser Trp Tyr Cys Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Trp Ala Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  215
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 antigen binding domain

<400>  215
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg tgtccggcta caccctgacc gagctgtcga tgcactgggt ccgccaggca      120

cctggcaagg gactggaatg gatgggcggc tttgaccccg aggacggcga gacaatctac      180

gcccagaaat tccagggcag agtgaccatg accgaggaca ccagcaccga caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgctgtgt attactgtgc aacagatctg      300

tatagcagca gctggtactg tgatgctttt gatatctggg gccaagggac aatggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc      480

atcacctgtc gggccagcca gtcgatcagc agctacctga actggtatca gcagaagccc      540

ggcaaggccc ccaagctgct gatctacgcc gccagctccc tgcagagcgg cgtgccaagc      600

agattcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagcag cctgcagccc      660

gaggacttcg ccacctacta ctgccagcag agttgggcca gcacccctct cactttcggc      720

ggagggacca aggtggagat caaa                                             744


<210>  216
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 antigen binding domain

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Gly Val Val Lys Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Phe Pro Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  217
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV E6 antigen binding domain

<400>  217
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctactgga tgcactgggt ccgccaggcc      120

cctggcaagg gactggtctg ggtgtctcga atcaacagcg acggcagcag caccagctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc cagggagaac      300

ggcgtggtga agtggtactt cgacctgtgg ggccgtggca ccctggtcac tgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagcag cctgagcgcc agcgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatcag cagctacctg aactggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacgc cgccagctcc ctgcagagcg gcgtgccaag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gagttacagt acccctctct ttcccttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  218
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 antigen binding domain

<400>  218

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Arg Gly Ser Pro Phe Tyr Gly Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  219
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV E6 antigen binding domain

<400>  219
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc caaggacggc      300

aggggctccc ccttctacgg cggcgccttc gacatctggg gccaagggac aatggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      600

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      660

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  220
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E7 antigen binding domain

<400>  220

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Ser Tyr Asp Tyr Leu Leu Asn Pro Tyr Arg Trp Asn 
            100                 105                 110         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  221
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV E7 antigen binding domain

<400>  221
gaagtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttctcg aacgcctgga tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtcggacgg atcaagagca agaccgacgg cggcaccacc      180

gactacgctg cccccgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtatta ctgtaccacc      300

tcctacgatt accttctcaa tccttatcgt tggaactggt tcgacccctg gggccaggga      360

accctggtca ccgtgtcctc aggcggaggt ggaagcggag ggggaggatc tggcggcgga      420

ggaagcggcg gagacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga      480

gacagagtca ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat      540

cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt      600

ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc      660

agtctgcaac ctgaagattt tgcaacttac tactgtcaac agagttacag tacccctctc      720

actttcggcg gcggaacaaa ggtggagatc aag                                   753


<210>  222
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 antigen binding domain

<400>  222

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Asp Thr Phe Ser Met Val Thr Leu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Trp Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  223
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAGE-A3 antigen binding domain

<400>  223
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg ccagcggcgg caccttcagc agctacgcca tcagctgggt ccgccaggct      120

cctggacagg gactggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agagcaccag caccgcctac      240

atggaactga gcagccttcg aagcgaggac accgctgtgt attactgtgc cagggacatg      300

gacaccttct ccatggtgac cctgttcgac tactggggcc agggcaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagagccc cagcagcctg agcgccagcg tgggcgacag agtgaccatc      480

acctgtcggg ccagccagtc gatcagcagc tacctgaact ggtatcagca gaagcccggc      540

aaggccccca agctgctgat ctacgccgcc agctccctgc agagcggcgt gccaagcaga      600

ttcagcggca gcggctccgg caccgacttc accctgacca tcagcagcct gcagcccgag      660

gacttcgcca cctactactg ccagcagagt tacagttggc ctctcacttt cggcggaggg      720

accaaggtgg agatcaaa                                                    738


<210>  224
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS G12V antigen binding domain

<400>  224

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Tyr Asp Glu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Trp Thr Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  225
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS G12V antigen binding domain

<400>  225
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcggga tgtgcgtgtc ctggattcga      120

cagccccctg gcaaggccct ggaatggctg gccctgattg actgggacga cgacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cgtattactg tgcacggagt      300

tacgacgagc tctactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagctc cctctctgca tctgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatctg gaccagctac ctgaactggt atcagcagaa gcccggcaag      540

gcccccaagc tgctgatcta cgccgccagc tccctgcaga gcggcgtgcc aagcagattc      600

agcggcagcg gctccggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgccacct actactgcca gcagagttac agtacccctc tcactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  226
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  226

Gly Gly Gly Gly Ser 
1               5   


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  227

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  228
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  228

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  229
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  229

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  230
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  230

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  231
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  231

Gly Gly Gly Ser 
1               


<210>  232
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  232

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Thr Arg Asp Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
            100                 105                 110         


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  233
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  233
caggtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactactaca tgagctggat cagacaggcc      120

cctggcaagg gactggaatg ggtgtcctac atcagcagca gcggctcgac catctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc cagggacttc      300

accagggact actactacta ctactacatg gacgtgtggg gcaaagggac cacggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      600

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      660

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  234
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  234

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Tyr Asp Glu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  235
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  235
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcggga tgtgcgtgtc ctggattcga      120

cagccccctg gcaaggccct ggaatggctg gccctgattg actgggacga cgacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cgtattactg tgcacggagt      300

tacgacgagc tctactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt      660

gcaacttact actgtcaaca gagttacagt acccctctca ctttcggcgg cggaacaaag      720

gtggagatca ag                                                          732


<210>  236
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  236

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Tyr Asp Glu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Trp Thr Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  237
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  237
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcggga tgtgcgtgtc ctggattcga      120

cagccccctg gcaaggccct ggaatggctg gccctgattg actgggacga cgacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cgtattactg tgcacggagt      300

tacgacgagc tctactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagctc cctctctgca tctgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatctg gaccagctac ctgaactggt atcagcagaa gcccggcaag      540

gcccccaagc tgctgatcta cgccgccagc tccctgcaga gcggcgtgcc aagcagattc      600

agcggcagcg gctccggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgccacct actactgcca gcagagttac agtacccctc tcactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  238
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  238

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Tyr Asp Glu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Arg Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  239
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS ScFv

<400>  239
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcggga tgtgcgtgtc ctggattcga      120

cagccccctg gcaaggccct ggaatggctg gccctgattg actgggacga cgacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cgtattactg tgcacggagt      300

tacgacgagc tctactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagctc cctctctgca tctgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatcag cagctacctg aactggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacgc cgccagctcc ctgcagagcg gcgtgccaag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gagttacagt acccggctca ctttcggcgg agggaccaag      720

gtggagatca aa                                                          732


<210>  240
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCR alpha

<400>  240

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Asp Gln Val Glu Gln Ser Pro Ser Ala Leu Ser 
            20                  25                  30          


Leu His Glu Gly Thr Asp Ser Ala Leu Arg Cys Asn Phe Thr Thr Thr 
        35                  40                  45              


Met Arg Ser Val Gln Trp Phe Arg Gln Asn Ser Arg Gly Ser Leu Ile 
    50                  55                  60                  


Ser Leu Phe Tyr Leu Ala Ser Gly Thr Lys Glu Asn Gly Arg Leu Lys 
65                  70                  75                  80  


Ser Ala Phe Asp Ser Lys Glu Arg Arg Tyr Ser Thr Leu His Ile Arg 
                85                  90                  95      


Asp Ala Gln Leu Glu Asp Ser Gly Thr Tyr Phe Cys Ala Ala Asp Ser 
            100                 105                 110         


Ser Asn Thr Gly Tyr Gln Asn Phe Tyr Phe Gly Lys Gly Thr Ser Leu 
        115                 120                 125             


Thr Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser 
                


<210>  241
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS TCR alpha

<400>  241
atgcagagga acctgggagc tgtgctgggg attctgtggg tgcagatttg ctgggtgaga       60

ggggatcagg tggagcagag tccttcagcc ctgagcctcc acgagggaac cgattctgct      120

ctgagatgca attttacgac caccatgagg agtgtgcagt ggttccgaca gaattccagg      180

ggcagcctca tcagtttgtt ctacttggct tcaggaacaa aggagaatgg gaggctaaag      240

tcagcatttg attctaagga gcggcgctac agcaccctgc acatcaggga tgcccagctg      300

gaggactcag gcacttactt ctgtgctgct gactcttcga acacgggtta ccagaacttc      360

tattttggga aaggaacaag tttgactgtc attccaaaca tccagaaccc agaacctgct      420

gtgtaccagt taaaagatcc tcggtctcag gacagcaccc tctgcctgtt caccgacttt      480

gactcccaaa tcaatgtgcc gaaaaccatg gaatctggaa cgttcatcac tgacaaatgt      540

gtgctggaca tgaaagctat ggattccaag agcaatgggg ccattgcctg gagcaaccag      600

acaagcttca cctgccaaga tatcttcaaa gagaccaacg ccacctaccc cagttcagac      660

gttccctgtg atgccacgtt gaccgagaaa agctttgaaa cagatatgaa cctgaacttt      720

caaaacctgt ct                                                          732


<210>  242
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCR beta

<400>  242

Met Ser Asn Thr Ala Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu 
1               5                   10                  15      


Ser Trp Val Ala Leu Phe Leu Leu Gly Thr Ser Ser Ala Asn Ser Gly 
            20                  25                  30          


Val Val Gln Ser Pro Arg Tyr Ile Ile Lys Gly Lys Gly Glu Arg Ser 
        35                  40                  45              


Ile Leu Lys Cys Ile Pro Ile Ser Gly His Leu Ser Val Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Thr Gln Gly Gln Glu Leu Lys Phe Phe Ile Gln His Tyr Asp 
65                  70                  75                  80  


Lys Met Glu Arg Asp Lys Gly Asn Leu Pro Ser Arg Phe Ser Val Gln 
                85                  90                  95      


Gln Phe Asp Asp Tyr His Ser Glu Met Asn Met Ser Ala Leu Glu Leu 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Leu Thr Asp Pro Leu 
        115                 120                 125             


Asp Ser Asp Tyr Thr Phe Gly Ser Gly Thr Arg Leu Leu Val Ile Glu 
    130                 135                 140                 


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
145                 150                 155                 160 


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
                165                 170                 175     


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            180                 185                 190         


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
        195                 200                 205             


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
    210                 215                 220                 


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
225                 230                 235                 240 


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
                245                 250                 255     


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
            260                 265                 270         


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
        275                 280             


<210>  243
<211>  849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS TCR beta

<400>  243
atgtctaaca ctgccttccc tgaccccgcc tggaacacca ccctgctatc ttgggttgct       60

ctctttctcc tgggaacaag ttcagcaaat tctggggttg tccagtctcc aagatacata      120

atcaaaggaa agggagaaag gtccattcta aaatgtattc ccatctctgg acatctctct      180

gtggcctggt atcaacagac tcaggggcag gaactaaagt tcttcattca gcattatgat      240

aaaatggaga gagataaagg aaacctgccc agcagattct cagtccaaca gtttgatgac      300

tatcactctg agatgaacat gagtgccttg gagctagagg actctgccgt gtacttctgt      360

gccagctctc tcacagatcc gctagactcc gactacacct tcggctcagg gaccaggctt      420

ttggtaatag aggatctgag aaatgtgact ccacccaagg tctccttgtt tgagccatca      480

aaagcagaga ttgcaaacaa acaaaaggct accctcgtgt gcttggccag gggcttcttc      540

cctgaccacg tggagctgag ctggtgggtg aatggcaagg aggtccacag tggggtctgc      600

acggaccctc aggcctacaa ggagagcaat tatagctact gcctgagcag ccgcctgagg      660

gtctctgcta ccttctggca caatcctcgc aaccacttcc gctgccaagt gcagttccat      720

gggctttcag aggaggacaa gtggccagag ggctcaccca aacctgtcac acagaacatc      780

agtgcagagg cctggggccg agcagactgt gggattacct cagcatccta tcaacaaggg      840

gtcttgtct                                                              849


<210>  244
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCR beta

<400>  244

Met Ser Asn Thr Ala Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu 
1               5                   10                  15      


Ser Trp Val Ala Leu Phe Leu Leu Gly Thr Ser Ser Ala Asn Ser Gly 
            20                  25                  30          


Val Val Gln Ser Pro Arg Tyr Ile Ile Lys Gly Lys Gly Glu Arg Ser 
        35                  40                  45              


Ile Leu Lys Cys Ile Pro Ile Ser Gly His Leu Ser Val Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Thr Gln Gly Gln Glu Leu Lys Phe Phe Ile Gln His Tyr Asp 
65                  70                  75                  80  


Lys Met Glu Arg Asp Lys Gly Asn Leu Pro Ser Arg Phe Ser Val Gln 
                85                  90                  95      


Gln Phe Asp Asp Tyr His Ser Glu Met Asn Met Ser Ala Leu Glu Leu 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Leu Thr Asp Pro Leu 
        115                 120                 125             


Asp Ser Asp Tyr Thr Phe Gly Ser Gly Thr Arg Leu Leu Val Ile Glu 
    130                 135                 140                 


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
145                 150                 155                 160 


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
                165                 170                 175     


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            180                 185                 190         


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
        195                 200                 205             


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
    210                 215                 220                 


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
225                 230                 235                 240 


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
                245                 250                 255     


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
            260                 265                 270         


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
        275                 280             


<210>  245
<211>  849
<212>  DNA
<213>  KRAS TCR beta

<400>  245
atgtctaaca ctgccttccc tgaccccgcc tggaacacca ccctgctatc ttgggttgct       60

ctctttctcc tgggaacaag ttcagcaaat tctggggttg tccagtctcc aagatacata      120

atcaaaggaa agggagaaag gtccattcta aaatgtattc ccatctctgg acatctctct      180

gtggcctggt atcaacagac tcaggggcag gaactaaagt tcttcattca gcattatgat      240

aaaatggaga gagataaagg aaacctgccc agcagattct cagtccaaca gtttgatgac      300

tatcactctg agatgaacat gagtgccttg gagctagagg actctgccgt gtacttctgt      360

gccagctctc tcacagatcc gctagactcc gactacacct tcggctcagg gaccaggctt      420

ttggtaatag aggatctgag aaatgtgact ccacccaagg tctccttgtt tgagccatca      480

aaagcagaga ttgcaaacaa acaaaaggct accctcgtgt gcttggccag gggcttcttc      540

cctgaccacg tggagctgag ctggtgggtg aatggcaagg aggtccacag tggggtctgc      600

acggaccctc aggcctacaa ggagagcaat tatagctact gcctgagcag ccgcctgagg      660

gtctctgcta ccttctggca caatcctcgc aaccacttcc gctgccaagt gcagttccat      720

gggctttcag aggaggacaa gtggccagag ggctcaccca aacctgtcac acagaacatc      780

agtgcagagg cctggggccg agcagactgt gggattacct cagcatccta tcaacaaggg      840

gtcttgtct                                                              849


<210>  246
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCRa

<400>  246

Met Lys Thr Val Thr Gly Pro Leu Phe Leu Cys Phe Trp Leu Gln Leu 
1               5                   10                  15      


Asn Cys Val Ser Arg Gly Glu Gln Val Glu Gln Arg Pro Pro His Leu 
            20                  25                  30          


Ser Val Arg Glu Gly Asp Ser Ala Val Ile Thr Cys Thr Tyr Thr Asp 
        35                  40                  45              


Pro Asn Ser Tyr Tyr Phe Phe Trp Tyr Lys Gln Glu Pro Gly Ala Ser 
    50                  55                  60                  


Leu Gln Leu Leu Met Lys Val Phe Ser Ser Thr Glu Ile Asn Glu Gly 
65                  70                  75                  80  


Gln Gly Phe Thr Val Leu Leu Asn Lys Lys Asp Lys Arg Leu Ser Leu 
                85                  90                  95      


Asn Leu Thr Ala Ala His Pro Gly Asp Ser Ala Ala Tyr Phe Cys Ala 
            100                 105                 110         


Val Ser Gly Gly Thr Asn Ser Ala Gly Asn Lys Leu Thr Phe Gly Ile 
        115                 120                 125             


Gly Thr Arg Val Leu Val Arg Pro Asp Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser 
                245             


<210>  247
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS TCRa

<400>  247
atgaagacgg tgactggacc tttgttcctg tgcttctggc tgcagctgaa ctgtgtgagc       60

agaggcgagc aggtggagca gcgccctcct cacctgagtg tccgggaggg agacagtgcc      120

gttatcacct gcacctacac agaccctaac agttattact tcttctggta caagcaagag      180

ccgggggcaa gtcttcagtt gcttatgaag gttttctcaa gtacggaaat aaacgaagga      240

caaggattca ctgtcctact gaacaagaaa gacaaacgac tctctctgaa cctcacagct      300

gcccatcctg gggactcagc cgcgtacttc tgcgcagtca gtggagggac taacagtgca      360

gggaacaagc taacttttgg aattggaacc agggtgctgg tcaggccaga catccagaac      420

ccagaacctg ctgtgtacca gttaaaagat cctcggtctc aggacagcac cctctgcctg      480

ttcaccgact ttgactccca aatcaatgtg ccgaaaacca tggaatctgg aacgttcatc      540

actgacaaat gtgtgctgga catgaaagct atggattcca agagcaatgg ggccattgcc      600

tggagcaacc agacaagctt cacctgccaa gatatcttca aagagaccaa cgccacctac      660

cccagttcag acgttccctg tgatgccacg ttgaccgaga aaagctttga aacagatatg      720

aacctgaact ttcaaaacct gtct                                             744


<210>  248
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCRb

<400>  248

Met Gly Cys Arg Leu Leu Ser Cys Val Ala Phe Cys Leu Leu Gly Ile 
1               5                   10                  15      


Gly Pro Leu Glu Thr Ala Val Phe Gln Thr Pro Asn Tyr His Val Thr 
            20                  25                  30          


Gln Val Gly Asn Glu Val Ser Phe Asn Cys Lys Gln Thr Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Leu Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Gln Leu Ile Val Asn Glu Thr Val Pro 
65                  70                  75                  80  


Arg Arg Phe Ser Pro Gln Ser Ser Asp Lys Ala His Leu Asn Leu Arg 
                85                  90                  95      


Ile Lys Ser Val Glu Pro Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Asp Trp Gly Pro Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


<210>  249
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS TCRb

<400>  249
atgggctgta ggctcctaag ctgtgtggcc ttctgcctct tgggaatagg ccctttggag       60

acagctgttt tccagactcc aaactatcat gtcacacagg tgggaaatga agtgtctttc      120

aattgtaagc aaactctggg ccacgatact atgtattggt acaagcaaga ctctaagaaa      180

ttgctgaaga ttatgtttag ctacaataat aagcaactca ttgtaaacga aacagttcca      240

aggcgcttct cacctcagtc ttcagataaa gctcatttga atcttcgaat caagtctgta      300

gagccggagg actctgctgt gtatctctgt gccagcagtc gggactgggg gcctgctgag      360

cagttcttcg gaccagggac acgactcacc gtcctagagg atctgagaaa tgtgactcca      420

cccaaggtct ccttgtttga gccatcaaaa gcagagattg caaacaaaca aaaggctacc      480

ctcgtgtgct tggccagggg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      540

ggcaaggagg tccacagtgg ggtctgcacg gaccctcagg cctacaagga gagcaattat      600

agctactgcc tgagcagccg cctgagggtc tctgctacct tctggcacaa tcctcgaaac      660

cacttccgct gccaagtgca gttccatggg ctttcagagg aggacaagtg gccagagggc      720

tcacccaaac ctgtcacaca gaacatcagt gcagaggcct ggggccgagc agactgtgga      780

atcacttcag catcctatca tcagggggtt ctgtct                                816


<210>  250
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCRb

<400>  250

Met Gly Cys Arg Leu Leu Ser Cys Val Ala Phe Cys Leu Leu Gly Ile 
1               5                   10                  15      


Gly Pro Leu Glu Thr Ala Val Phe Gln Thr Pro Asn Tyr His Val Thr 
            20                  25                  30          


Gln Val Gly Asn Glu Val Ser Phe Asn Cys Lys Gln Thr Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Leu Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Gln Leu Ile Val Asn Glu Thr Val Pro 
65                  70                  75                  80  


Arg Arg Phe Ser Pro Gln Ser Ser Asp Lys Ala His Leu Asn Leu Arg 
                85                  90                  95      


Ile Lys Ser Val Glu Pro Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Asp Trp Gly Pro Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         


<210>  251
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS TCRb

<400>  251
atgggctgta ggctcctaag ctgtgtggcc ttctgcctct tgggaatagg ccctttggag       60

acagctgttt tccagactcc aaactatcat gtcacacagg tgggaaatga agtgtctttc      120

aattgtaagc aaactctggg ccacgatact atgtattggt acaagcaaga ctctaagaaa      180

ttgctgaaga ttatgtttag ctacaataat aagcaactca ttgtaaacga aacagttcca      240

aggcgcttct cacctcagtc ttcagataaa gctcatttga atcttcgaat caagtctgta      300

gagccggagg actctgctgt gtatctctgt gccagcagtc gggactgggg gcctgctgag      360

cagttcttcg gaccagggac acgactcacc gtcctagagg atctgagaaa tgtgactcca      420

cccaaggtct ccttgtttga gccatcaaaa gcagagattg caaacaaaca aaaggctacc      480

ctcgtgtgct tggccagggg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      540

ggcaaggagg tccacagtgg ggtctgcacg gaccctcagg cctacaagga gagcaattat      600

agctactgcc tgagcagccg cctgagggtc tctgctacct tctggcacaa tcctcgaaac      660

cacttccgct gccaagtgca gttccatggg ctttcagagg aggacaagtg gccagagggc      720

tcacccaaac ctgtcacaca gaacatcagt gcagaggcct ggggccgagc agactgtgga      780

atcacttcag catcctatca tcagggggtt ctgtct                                816


<210>  252
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRa control

<400>  252

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Asp Gln Val Glu Gln Ser Pro Ser Ala Leu Ser 
            20                  25                  30          


Leu His Glu Gly Thr Asp Ser Ala Leu Arg Cys Asn Phe Thr Thr Thr 
        35                  40                  45              


Met Arg Ser Val Gln Trp Phe Arg Gln Asn Ser Arg Gly Ser Leu Ile 
    50                  55                  60                  


Ser Leu Phe Tyr Leu Ala Ser Gly Thr Lys Glu Asn Gly Arg Leu Lys 
65                  70                  75                  80  


Ser Ala Phe Asp Ser Lys Glu Arg Arg Tyr Ser Thr Leu His Ile Arg 
                85                  90                  95      


Asp Ala Gln Leu Glu Asp Ser Gly Thr Tyr Phe Cys Ala Ala Asp Ser 
            100                 105                 110         


Ser Asn Thr Gly Tyr Gln Asn Phe Tyr Phe Gly Lys Gly Thr Ser Leu 
        115                 120                 125             


Thr Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser 
                


<210>  253
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCRa control

<400>  253
atgcagagga acctgggagc tgtgctgggg attctgtggg tgcagatttg ctgggtgaga       60

ggggatcagg tggagcagag tccttcagcc ctgagcctcc acgagggaac cgattctgct      120

ctgagatgca attttacgac caccatgagg agtgtgcagt ggttccgaca gaattccagg      180

ggcagcctca tcagtttgtt ctacttggct tcaggaacaa aggagaatgg gaggctaaag      240

tcagcatttg attctaagga gcggcgctac agcaccctgc acatcaggga tgcccagctg      300

gaggactcag gcacttactt ctgtgctgct gactcttcga acacgggtta ccagaacttc      360

tattttggga aaggaacaag tttgactgtc attccaaaca tccagaaccc agaacctgct      420

gtgtaccagt taaaagatcc tcggtctcag gacagcaccc tctgcctgtt caccgacttt      480

gactcccaaa tcaatgtgcc gaaaaccatg gaatctggaa cgttcatcac tgacaaatgt      540

gtgctggaca tgaaagctat ggattccaag agcaatgggg ccattgcctg gagcaaccag      600

acaagcttca cctgccaaga tatcttcaaa gagaccaacg ccacctaccc cagttcagac      660

gttccctgtg atgccacgtt gaccgagaaa agctttgaaa cagatatgaa cctgaacttt      720

caaaacctgt ct                                                          732


<210>  254
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCRa control

<400>  254

Met Lys Thr Val Thr Gly Pro Leu Phe Leu Cys Phe Trp Leu Gln Leu 
1               5                   10                  15      


Asn Cys Val Ser Arg Gly Glu Gln Val Glu Gln Arg Pro Pro His Leu 
            20                  25                  30          


Ser Val Arg Glu Gly Asp Ser Ala Val Ile Thr Cys Thr Tyr Thr Asp 
        35                  40                  45              


Pro Asn Ser Tyr Tyr Phe Phe Trp Tyr Lys Gln Glu Pro Gly Ala Ser 
    50                  55                  60                  


Leu Gln Leu Leu Met Lys Val Phe Ser Ser Thr Glu Ile Asn Glu Gly 
65                  70                  75                  80  


Gln Gly Phe Thr Val Leu Leu Asn Lys Lys Asp Lys Arg Leu Ser Leu 
                85                  90                  95      


Asn Leu Thr Ala Ala His Pro Gly Asp Ser Ala Ala Tyr Phe Cys Ala 
            100                 105                 110         


Val Ser Gly Gly Thr Asn Ser Ala Gly Asn Lys Leu Thr Phe Gly Ile 
        115                 120                 125             


Gly Thr Arg Val Leu Val Arg Pro Asp Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser 
                245             


<210>  255
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCRa control

<400>  255
atgaagacgg tgactggacc tttgttcctg tgcttctggc tgcagctgaa ctgtgtgagc       60

agaggcgagc aggtggagca gcgccctcct cacctgagtg tccgggaggg agacagtgcc      120

gttatcacct gcacctacac agaccctaac agttattact tcttctggta caagcaagag      180

ccgggggcaa gtcttcagtt gcttatgaag gttttctcaa gtacggaaat aaacgaagga      240

caaggattca ctgtcctact gaacaagaaa gacaaacgac tctctctgaa cctcacagct      300

gcccatcctg gggactcagc cgcgtacttc tgcgcagtca gtggagggac taacagtgca      360

gggaacaagc taacttttgg aattggaacc agggtgctgg tcaggccaga catccagaac      420

ccagaacctg ctgtgtacca gttaaaagat cctcggtctc aggacagcac cctctgcctg      480

ttcaccgact ttgactccca aatcaatgtg ccgaaaacca tggaatctgg aacgttcatc      540

actgacaaat gtgtgctgga catgaaagct atggattcca agagcaatgg ggccattgcc      600

tggagcaacc agacaagctt cacctgccaa gatatcttca aagagaccaa cgccacctac      660

cccagttcag acgttccctg tgatgccacg ttgaccgaga aaagctttga aacagatatg      720

aacctgaact ttcaaaacct gtct                                             744


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mH-Y-2Db peptide

<400>  256

Lys Cys Ser Arg Asn Arg Gln Tyr Leu 
1               5                   


<210>  257
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  257

Met Phe Pro Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Gln Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Ser Ser Pro Asp Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Asn Thr 
    290                 295                 300                 


Ala Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu Ser Trp Val Ala 
305                 310                 315                 320 


Leu Phe Leu Leu Gly Thr Lys His Met Glu Ala Ala Val Thr Gln Ser 
                325                 330                 335     


Pro Arg Asn Lys Val Ala Val Thr Gly Gly Lys Val Thr Leu Ser Cys 
            340                 345                 350         


Asn Gln Thr Asn Asn His Asn Asn Met Tyr Trp Tyr Arg Gln Asp Thr 
        355                 360                 365             


Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Ala Gly Ser Thr 
    370                 375                 380                 


Glu Lys Gly Asp Ile Pro Asp Gly Tyr Lys Ala Ser Arg Pro Ser Gln 
385                 390                 395                 400 


Glu Asn Phe Ser Leu Ile Leu Glu Leu Ala Thr Pro Ser Gln Thr Ser 
                405                 410                 415     


Val Tyr Phe Cys Ala Ser Gly Asp Asn Ser Ala Glu Thr Leu Tyr Phe 
            420                 425                 430         


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
        435                 440                 445             


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
    450                 455                 460                 


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
465                 470                 475                 480 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
                485                 490                 495     


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
            500                 505                 510         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
        515                 520                 525             


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
    530                 535                 540                 


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
545                 550                 555                 560 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His 
                565                 570                 575     


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
            580                 585                 590         


Ala Thr Leu Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met 
        595                 600                 605             


Val Lys Lys Lys Asn Ser 
    610                 


<210>  258
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  258
atgttccccg ttaccatatt gctcctgagt gctttcttca gtttgcgagg gaactctgcc       60

caatctgtcg atcagccaga tgcacacgtt accctttccg agggtgcgtc acttgaactg      120

aggtgttcct atagctactc agcagcccct tatctgtttt ggtacgtaca atacccaggg      180

cagagtctcc aatttctcct taaatatata accggggaca ctgtagtgaa ggggactaaa      240

ggttttgaag cagagtttag gaagagcaac agctccttca accttaagaa gtcacccgca      300

cactggtcag actccgcgaa atacttctgt gctctggaag ggcaagacca gggtggaagt      360

gccaaattga tatttggtga gggtactaaa ttgactgtta gctcaccaga catccagaac      420

ccagaacctg ctgtgtacca gttaaaagat cctcggtctc aggacagcac cctctgcctg      480

ttcaccgact ttgactccca aatcaatgtg ccgaaaacca tggaatctgg aacgttcatc      540

actgacaaaa ctgtgctgga catgaaagct atggattcca agagcaatgg ggccattgcc      600

tggagcaacc agacaagctt cacctgccaa gatatcttca aagagaccaa cgccacctac      660

cccagttcag acgttccctg tgatgccacg ttgaccgaga aaagctttga aacagatatg      720

aacctaaact ttcaaaacct gtcagttatg ggactccgaa tcctcctgct gaaagtagcg      780

ggatttaacc tgctcatgac gctgaggctg tggtccagtc gggccaagcg gtccggatcc      840

ggagccacca acttcagcct gctgaagcag gccggcgacg tggaggagaa ccccggcccc      900

atgtctaata ctgcatttcc agatccggcc tggaatacta cactccttag ttgggttgcc      960

ctcttcctcc ttggcacgaa gcacatggaa gccgccgtca cccagagtcc gagaaacaaa     1020

gtagcggtca ccggcggtaa ggtaacattg agttgtaacc aaacgaacaa ccataacaat     1080

atgtactggt atagacaaga cacaggccat ggcttgcgcc tgattcacta cagctatgga     1140

gcggggagta cggagaaggg tgatattccc gatggctata aagcctctcg gcctagccag     1200

gagaatttta gtttgatcct ggagctcgca acccccagtc agactagcgt ctacttttgt     1260

gcctcaggcg acaatagtgc ggaaaccctt tacttcggcc ctgggacaag acttacagtt     1320

ctagaggatc tgagaaatgt gactccaccc aaggtctcct tgtttgagcc atcaaaagca     1380

gagattgcaa acaaacaaaa ggctaccctc gtgtgcttgg ccaggggctt cttccctgac     1440

cacgtggagc tgagctggtg ggtgaatggc aaggaggtcc acagtggggt cagcacggac     1500

cctcaggcct acaaggagag caattatagc tactgcctga gcagccgcct gagggtctct     1560

gctaccttct ggcacaatcc tcgaaaccac ttccgctgcc aagtgcagtt ccatgggctt     1620

tcagaggagg acaagtggcc agagggctca cccaaacctg tcacacagaa catcagtgca     1680

gaggcctggg gccgagcaga ctgtggaatc acttcagcat cctatcatca gggggttctg     1740

tctgcaacca tcctctatga gatcctactg gggaaggcca ccctatatgc tgtgctggtc     1800

agtggcctgg tgctgatggc catggtcaag aaaaaaaatt cctag                     1845


<210>  259
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  259

Met Phe Pro Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Gln Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Ser Ser Pro Tyr Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
        275                 280                 285             


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Asn Thr Ala 
    290                 295                 300                 


Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu Ser Trp Val Ala Leu 
305                 310                 315                 320 


Phe Leu Leu Gly Thr Lys His Met Glu Ala Ala Val Thr Gln Ser Pro 
                325                 330                 335     


Arg Asn Lys Val Ala Val Thr Gly Gly Lys Val Thr Leu Ser Cys Asn 
            340                 345                 350         


Gln Thr Asn Asn His Asn Asn Met Tyr Trp Tyr Arg Gln Asp Thr Gly 
        355                 360                 365             


His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Ala Gly Ser Thr Glu 
    370                 375                 380                 


Lys Gly Asp Ile Pro Asp Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu 
385                 390                 395                 400 


Asn Phe Ser Leu Ile Leu Glu Leu Ala Thr Pro Ser Gln Thr Ser Val 
                405                 410                 415     


Tyr Phe Cys Ala Ser Gly Asp Asn Ser Ala Glu Thr Leu Tyr Phe Gly 
            420                 425                 430         


Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro 
        435                 440                 445             


Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr 
    450                 455                 460                 


Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His 
465                 470                 475                 480 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                485                 490                 495     


Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser 
            500                 505                 510         


Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln 
        515                 520                 525             


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser 
    530                 535                 540                 


Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile 
545                 550                 555                 560 


Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu 
                565                 570                 575     


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
            580                 585                 590         


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu 
        595                 600                 605             


Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
    610                 615                 


<210>  260
<211>  1860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  260
atgttccccg ttaccatatt gctcctgagt gctttcttca gtttgcgagg gaactctgcc       60

caatctgtcg atcagccaga tgcacacgtt accctttccg agggtgcgtc acttgaactg      120

aggtgttcct atagctactc agcagcccct tatctgtttt ggtacgtaca atacccaggg      180

cagagtctcc aatttctcct taaatatata accggggaca ctgtagtgaa ggggactaaa      240

ggttttgaag cagagtttag gaagagcaac agctccttca accttaagaa gtcacccgca      300

cactggtcag actccgcgaa atacttctgt gctctggaag ggcaagacca gggtggaagt      360

gccaaattga tatttggtga gggtactaaa ttgactgtta gctcaccgta tatccagaac      420

cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta      480

ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc      540

acagacaaat gtgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc      600

tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa      660

gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt      720

gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc      780

ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag cggatccgga      840

gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg      900

tctaatactg catttccaga tccggcctgg aatactacac tccttagttg ggttgccctc      960

ttcctccttg gcacgaagca catggaagcc gccgtcaccc agagtccgag aaacaaagta     1020

gcggtcaccg gcggtaaggt aacattgagt tgtaaccaaa cgaacaacca taacaatatg     1080

tactggtata gacaagacac aggccatggc ttgcgcctga ttcactacag ctatggagcg     1140

gggagtacgg agaagggtga tattcccgat ggctataaag cctctcggcc tagccaggag     1200

aattttagtt tgatcctgga gctcgcaacc cccagtcaga ctagcgtcta cttttgtgcc     1260

tcaggcgaca atagtgcgga aaccctttac ttcggccctg ggacaagact tacagttctg     1320

gaggacctga aaaacgtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag     1380

atctcccaca cccaaaaggc cacactggtg tgcctggcca caggcttcta ccccgaccac     1440

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtctg cacagacccg     1500

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg     1560

agggtgtcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc     1620

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacctgt cacccagatc     1680

gtcagcgccg aggcctgggg tagagcagac tgtggcttca cctccgagtc ttaccagcaa     1740

ggggtcctgt ctgccaccat cctctatgag atcttgctag ggaaggccac cttgtatgcc     1800

gtgctggtca gtgccctcgt gctgatggcc atggtcaaga gaaaggattc cagaggctag     1860


<210>  261
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  261

Met Phe Pro Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Gln Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Ser Ser Pro Asp Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Asn Thr 
    290                 295                 300                 


Ala Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu Ser Trp Val Ala 
305                 310                 315                 320 


Leu Phe Leu Leu Gly Thr Lys His Met Glu Ala Ala Val Thr Gln Ser 
                325                 330                 335     


Pro Arg Asn Lys Val Ala Val Thr Gly Gly Lys Val Thr Leu Ser Cys 
            340                 345                 350         


Asn Gln Thr Asn Asn His Asn Asn Met Tyr Trp Tyr Arg Gln Asp Thr 
        355                 360                 365             


Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Ala Gly Ser Thr 
    370                 375                 380                 


Glu Lys Gly Asp Ile Pro Asp Gly Tyr Lys Ala Ser Arg Pro Ser Gln 
385                 390                 395                 400 


Glu Asn Phe Ser Leu Ile Leu Glu Leu Ala Thr Pro Ser Gln Thr Ser 
                405                 410                 415     


Val Tyr Phe Cys Ala Ser Gly Asp Asn Ser Ala Glu Thr Leu Tyr Phe 
            420                 425                 430         


Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr 
        435                 440                 445             


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
    450                 455                 460                 


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
465                 470                 475                 480 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
                485                 490                 495     


Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
            500                 505                 510         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
        515                 520                 525             


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
    530                 535                 540                 


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
545                 550                 555                 560 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His 
                565                 570                 575     


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
            580                 585                 590         


Ala Thr Leu Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met 
        595                 600                 605             


Val Lys Lys Lys Asn Ser 
    610                 


<210>  262
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  262
atgttccccg ttaccatatt gctcctgagt gctttcttca gtttgcgagg gaactctgcc       60

caatctgtcg atcagccaga tgcacacgtt accctttccg agggtgcgtc acttgaactg      120

aggtgttcct atagctactc agcagcccct tatctgtttt ggtacgtaca atacccaggg      180

cagagtctcc aatttctcct taaatatata accggggaca ctgtagtgaa ggggactaaa      240

ggttttgaag cagagtttag gaagagcaac agctccttca accttaagaa gtcacccgca      300

cactggtcag actccgcgaa atacttctgt gctctggaag ggcaagacca gggtggaagt      360

gccaaattga tatttggtga gggtactaaa ttgactgtta gctcaccaga catccagaac      420

ccagaacctg ctgtgtacca gttaaaagat cctcggtctc aggacagcac cctctgcctg      480

ttcaccgact ttgactccca aatcaatgtg ccgaaaacca tggaatctgg aacgttcatc      540

actgacaaaa ctgtgctgga catgaaagct atggattcca agagcaatgg ggccattgcc      600

tggagcaacc agacaagctt cacctgccaa gatatcttca aagagaccaa cgccacctac      660

cccagttcag acgttccctg tgatgccacg ttgaccgaga aaagctttga aacagatatg      720

aacctaaact ttcaaaacct gtcagttatg ggactccgaa tcctcctgct gaaagtagcg      780

ggatttaacc tgctcatgac gctgaggctg tggtccagtc gggccaagcg gtccggatcc      840

ggagccacca acttcagcct gctgaagcag gccggcgacg tggaggagaa ccccggcccc      900

atgtctaata ctgcatttcc agatccggcc tggaatacta cactccttag ttgggttgcc      960

ctcttcctcc ttggcacgaa gcacatggaa gccgccgtca cccagagtcc gagaaacaaa     1020

gtagcggtca ccggcggtaa ggtaacattg agttgtaacc aaacgaacaa ccataacaat     1080

atgtactggt atagacaaga cacaggccat ggcttgcgcc tgattcacta cagctatgga     1140

gcggggagta cggagaaggg tgatattccc gatggctata aagcctctcg gcctagccag     1200

gagaatttta gtttgatcct ggagctcgca acccccagtc agactagcgt ctacttttgt     1260

gcctcaggcg acaatagtgc ggaaaccctt tacttcggcc ctgggacaag acttttggtt     1320

ctagaggatc tgagaaatgt gactccaccc aaggtctcct tgtttgagcc atcaaaagca     1380

gagattgcaa acaaacaaaa ggctaccctc gtgtgcttgg ccaggggctt cttccctgac     1440

cacgtggagc tgagctggtg ggtgaatggc aaggaggtcc acagtggggt cagcacggac     1500

cctcaggcct acaaggagag caattatagc tactgcctga gcagccgcct gagggtctct     1560

gctaccttct ggcacaatcc tcgaaaccac ttccgctgcc aagtgcagtt ccatgggctt     1620

tcagaggagg acaagtggcc agagggctca cccaaacctg tcacacagaa catcagtgca     1680

gaggcctggg gccgagcaga ctgtggaatc acttcagcat cctatcatca gggggttctg     1740

tctgcaacca tcctctatga gatcctactg gggaaggcca ccctatatgc tgtgctggtc     1800

agtggcctgg tgctgatggc catggtcaag aaaaaaaatt cctag                     1845


<210>  263
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  263

Met Phe Pro Val Thr Ile Leu Leu Leu Ser Ala Phe Phe Ser Leu Arg 
1               5                   10                  15      


Gly Asn Ser Ala Gln Ser Val Asp Gln Pro Asp Ala His Val Thr Leu 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Glu Leu Arg Cys Ser Tyr Ser Tyr Ser Ala 
        35                  40                  45              


Ala Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Thr Val Val Lys Gly Thr Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Arg Lys Ser Asn Ser Ser Phe Asn Leu Lys 
                85                  90                  95      


Lys Ser Pro Ala His Trp Ser Asp Ser Ala Lys Tyr Phe Cys Ala Leu 
            100                 105                 110         


Glu Gly Gln Asp Gln Gly Gly Ser Ala Lys Leu Ile Phe Gly Glu Gly 
        115                 120                 125             


Thr Lys Leu Thr Val Ser Ser Pro Tyr Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
        275                 280                 285             


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Asn Thr Ala 
    290                 295                 300                 


Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu Ser Trp Val Ala Leu 
305                 310                 315                 320 


Phe Leu Leu Gly Thr Lys His Met Glu Ala Ala Val Thr Gln Ser Pro 
                325                 330                 335     


Arg Asn Lys Val Ala Val Thr Gly Gly Lys Val Thr Leu Ser Cys Asn 
            340                 345                 350         


Gln Thr Asn Asn His Asn Asn Met Tyr Trp Tyr Arg Gln Asp Thr Gly 
        355                 360                 365             


His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Ala Gly Ser Thr Glu 
    370                 375                 380                 


Lys Gly Asp Ile Pro Asp Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu 
385                 390                 395                 400 


Asn Phe Ser Leu Ile Leu Glu Leu Ala Thr Pro Ser Gln Thr Ser Val 
                405                 410                 415     


Tyr Phe Cys Ala Ser Gly Asp Asn Ser Ala Glu Thr Leu Tyr Phe Gly 
            420                 425                 430         


Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro 
        435                 440                 445             


Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr 
    450                 455                 460                 


Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His 
465                 470                 475                 480 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                485                 490                 495     


Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser 
            500                 505                 510         


Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln 
        515                 520                 525             


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser 
    530                 535                 540                 


Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile 
545                 550                 555                 560 


Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu 
                565                 570                 575     


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
            580                 585                 590         


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu 
        595                 600                 605             


Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
    610                 615                 


<210>  264
<211>  1860
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-Y TCR alpha and beta

<400>  264
atgttccccg ttaccatatt gctcctgagt gctttcttca gtttgcgagg gaactctgcc       60

caatctgtcg atcagccaga tgcacacgtt accctttccg agggtgcgtc acttgaactg      120

aggtgttcct atagctactc agcagcccct tatctgtttt ggtacgtaca atacccaggg      180

cagagtctcc aatttctcct taaatatata accggggaca ctgtagtgaa ggggactaaa      240

ggttttgaag cagagtttag gaagagcaac agctccttca accttaagaa gtcacccgca      300

cactggtcag actccgcgaa atacttctgt gctctggaag ggcaagacca gggtggaagt      360

gccaaattga tatttggtga gggtactaaa ttgactgtta gctcaccgta tatccagaac      420

cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta      480

ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc      540

acagacaaat gtgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc      600

tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa      660

gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt      720

gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc      780

ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag cggatccgga      840

gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggccccatg      900

tctaatactg catttccaga tccggcctgg aatactacac tccttagttg ggttgccctc      960

ttcctccttg gcacgaagca catggaagcc gccgtcaccc agagtccgag aaacaaagta     1020

gcggtcaccg gcggtaaggt aacattgagt tgtaaccaaa cgaacaacca taacaatatg     1080

tactggtata gacaagacac aggccatggc ttgcgcctga ttcactacag ctatggagcg     1140

gggagtacgg agaagggtga tattcccgat ggctataaag cctctcggcc tagccaggag     1200

aattttagtt tgatcctgga gctcgcaacc cccagtcaga ctagcgtcta cttttgtgcc     1260

tcaggcgaca atagtgcgga aaccctttac ttcggccctg ggacaagact tttggttctg     1320

gaggacctga aaaacgtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag     1380

atctcccaca cccaaaaggc cacactggtg tgcctggcca caggcttcta ccccgaccac     1440

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtctg cacagacccg     1500

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg     1560

agggtgtcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc     1620

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacctgt cacccagatc     1680

gtcagcgccg aggcctgggg tagagcagac tgtggcttca cctccgagtc ttaccagcaa     1740

ggggtcctgt ctgccaccat cctctatgag atcttgctag ggaaggccac cttgtatgcc     1800

gtgctggtca gtgccctcgt gctgatggcc atggtcaaga gaaaggattc cagaggctag     1860


<210>  265
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1

<400>  265

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  266
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1(R) peptide

<400>  266

Val Leu Arg Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  267
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 TCR alpha and beta

<400>  267

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Met Ser Ile Gly Leu Leu Cys Cys 
    290                 295                 300                 


Ala Ala Leu Ser Leu Leu Trp Ala Gly Pro Val Asn Ala Gly Val Thr 
305                 310                 315                 320 


Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly Gln Ser Met Thr Leu 
                325                 330                 335     


Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met Ser Trp Tyr Arg Gln 
            340                 345                 350         


Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly Ala Gly 
        355                 360                 365             


Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg Ser 
    370                 375                 380                 


Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln 
385                 390                 395                 400 


Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Val Gly Asn Thr Gly Glu 
                405                 410                 415     


Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Lys 
            420                 425                 430         


Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        435                 440                 445             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    450                 455                 460                 


Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                485                 490                 495     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    530                 535                 540                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
        595                 600                 605         


<210>  268
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 TCR alpha and beta

<400>  268
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gcggatccgg agccaccaac      840

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat gagcatcggc      900

ctcctgtgct gtgcagcctt gtctctcctg tgggcaggtc cagtgaatgc tggtgtcact      960

cagaccccaa aattccaggt cctgaagaca ggacagagca tgacactgca gtgtgcccag     1020

gatatgaacc atgaatacat gtcctggtat cgacaagacc caggcatggg gctgaggctg     1080

attcattact cagttggtgc tggtatcact gaccaaggag aagtccccaa tggctacaat     1140

gtctccagat caaccacaga ggatttcccg ctcaggctgc tgtcggctgc tccctcccag     1200

acatctgtgt acttctgtgc cagcagttac gtcgggaaca ccggggagct gttttttgga     1260

gaaggctcta ggctgaccgt actggaggac ctgaaaaacg tgttcccacc cgaggtcgct     1320

gtgtttgagc catcagaagc agagatctcc cacacccaaa aggccacact ggtgtgcctg     1380

gccacaggct tctaccccga ccacgtggag ctgagctggt gggtgaatgg gaaggaggtg     1440

cacagtgggg tctgcacaga cccgcagccc ctcaaggagc agcccgccct caatgactcc     1500

agatactgcc tgagcagccg cctgagggtg tcggccacct tctggcagaa cccccgcaac     1560

cacttccgct gtcaagtcca gttctacggg ctctcggaga atgacgagtg gacccaggat     1620

agggccaaac ctgtcaccca gatcgtcagc gccgaggcct ggggtagagc agactgtggc     1680

ttcacctccg agtcttacca gcaaggggtc ctgtctgcca ccatcctcta tgagatcttg     1740

ctagggaagg ccaccttgta tgccgtgctg gtcagtgccc tcgtgctgat ggccatggtc     1800

aagagaaagg attccagagg ctag                                            1824


<210>  269
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS TCR

<400>  269

Met Gln Arg Asn Leu Gly Ala Val Leu Gly Ile Leu Trp Val Gln Ile 
1               5                   10                  15      


Cys Trp Val Arg Gly Asp Gln Val Glu Gln Ser Pro Ser Ala Leu Ser 
            20                  25                  30          


Leu His Glu Gly Thr Asp Ser Ala Leu Arg Cys Asn Phe Thr Thr Thr 
        35                  40                  45              


Met Arg Ser Val Gln Trp Phe Arg Gln Asn Ser Arg Gly Ser Leu Ile 
    50                  55                  60                  


Ser Leu Phe Tyr Leu Ala Ser Gly Thr Lys Glu Asn Gly Arg Leu Lys 
65                  70                  75                  80  


Ser Ala Phe Asp Ser Lys Glu Arg Arg Tyr Ser Thr Leu His Ile Arg 
                85                  90                  95      


Asp Ala Gln Leu Glu Asp Ser Gly Thr Tyr Phe Cys Ala Ala Asp Ser 
            100                 105                 110         


Ser Asn Thr Gly Tyr Gln Asn Phe Tyr Phe Gly Lys Gly Thr Ser Leu 
        115                 120                 125             


Thr Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys 
            260                 265                 270         


Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Met Ser Asn Thr Ala Phe Pro Asp 
    290                 295                 300                 


Pro Ala Trp Asn Thr Thr Leu Leu Ser Trp Val Ala Leu Phe Leu Leu 
305                 310                 315                 320 


Gly Thr Ser Ser Ala Asn Ser Gly Val Val Gln Ser Pro Arg Tyr Ile 
                325                 330                 335     


Ile Lys Gly Lys Gly Glu Arg Ser Ile Leu Lys Cys Ile Pro Ile Ser 
            340                 345                 350         


Gly His Leu Ser Val Ala Trp Tyr Gln Gln Thr Gln Gly Gln Glu Leu 
        355                 360                 365             


Lys Phe Phe Ile Gln His Tyr Asp Lys Met Glu Arg Asp Lys Gly Asn 
    370                 375                 380                 


Leu Pro Ser Arg Phe Ser Val Gln Gln Phe Asp Asp Tyr His Ser Glu 
385                 390                 395                 400 


Met Asn Met Ser Ala Leu Glu Leu Glu Asp Ser Ala Val Tyr Phe Cys 
                405                 410                 415     


Ala Ser Ser Leu Thr Asp Pro Leu Asp Ser Asp Tyr Thr Phe Gly Ser 
            420                 425                 430         


Gly Thr Arg Leu Leu Val Ile Glu Asp Leu Arg Asn Val Thr Pro Pro 
        435                 440                 445             


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
    450                 455                 460                 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
465                 470                 475                 480 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
                485                 490                 495     


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
            500                 505                 510         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
        515                 520                 525             


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
    530                 535                 540                 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
545                 550                 555                 560 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
                565                 570                 575     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            580                 585                 590         


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
        595                 600                 605             


Arg Lys Asn Ser 
    610         


<210>  270
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRAS TCR

<400>  270
atgcagagga acctgggagc tgtgctgggg attctgtggg tgcagatttg ctgggtgaga       60

ggggatcagg tggagcagag tccttcagcc ctgagcctcc acgagggaac cgattctgct      120

ctgagatgca attttacgac caccatgagg agtgtgcagt ggttccgaca gaattccagg      180

ggcagcctca tcagtttgtt ctacttggct tcaggaacaa aggagaatgg gaggctaaag      240

tcagcatttg attctaagga gcggcgctac agcaccctgc acatcaggga tgcccagctg      300

gaggactcag gcacttactt ctgtgctgct gactcttcga acacgggtta ccagaacttc      360

tattttggga aaggaacaag tttgactgtc attccaaaca tccagaaccc agaacctgct      420

gtgtaccagt taaaagatcc tcggtctcag gacagcaccc tctgcctgtt caccgacttt      480

gactcccaaa tcaatgtgcc gaaaaccatg gaatctggaa cgttcatcac tgacaaaact      540

gtgctggaca tgaaagctat ggattccaag agcaatgggg ccattgcctg gagcaaccag      600

acaagcttca cctgccaaga tatcttcaaa gagaccaacg ccacctaccc cagttcagac      660

gttccctgtg atgccacgtt gaccgagaaa agctttgaaa cagatatgaa cctgaacttt      720

caaaacctgt cagttatggg actccgaatc ctcctgctga aagtagcggg atttaacctg      780

ctcatgacgc tgaggctgtg gtccagtcgg gccaagcggt ccggatccgg agccaccaac      840

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc ccggccccat gtctaacact      900

gccttccctg accccgcctg gaacaccacc ctgctatctt gggttgctct ctttctcctg      960

ggaacaagtt cagcaaattc tggggttgtc cagtctccaa gatacataat caaaggaaag     1020

ggagaaaggt ccattctaaa atgtattccc atctctggac atctctctgt ggcctggtat     1080

caacagactc aggggcagga actaaagttc ttcattcagc attatgataa aatggagaga     1140

gataaaggaa acctgcccag cagattctca gtccaacagt ttgatgacta tcactctgag     1200

atgaacatga gtgccttgga gctagaggac tctgccgtgt acttctgtgc cagctctctc     1260

acagatccgc tagactccga ctacaccttc ggctcaggga ccaggctttt ggtaatagag     1320

gatctgagaa atgtgactcc acccaaggtc tccttgtttg agccatcaaa agcagagatt     1380

gcaaacaaac aaaaggctac cctcgtgtgc ttggccaggg gcttcttccc tgaccacgtg     1440

gagctgagct ggtgggtgaa tggcaaggag gtccacagtg gggtcagcac ggaccctcag     1500

gcctacaagg agagcaatta tagctactgc ctgagcagcc gcctgagggt ctctgctacc     1560

ttctggcaca atcctcgcaa ccacttccgc tgccaagtgc agttccatgg gctttcagag     1620

gaggacaagt ggccagaggg ctcacccaaa cctgtcacac agaacatcag tgcagaggcc     1680

tggggccgag cagactgtgg gattacctca gcatcctatc aacaaggggt cttgtctgcc     1740

accatcctct atgagatcct gctagggaaa gccaccctgt atgctgtgct tgtcagtaca     1800

ctggtggtga tggctatggt caaaagaaag aattcatag                            1839


<210>  271
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self cleaving peptide

<400>  271

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  272
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A self cleaving peptide

<400>  272

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  273
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A self cleaving peptide

<400>  273

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  274
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM


<220>
<221>  Z
<222>  (1)..(1)
<223>  Z is S, I V or L

<220>
<221>  X
<222>  (2)..(2)
<223>  X is any amino acid

<220>
<221>  X
<222>  (4)..(5)
<223>  X is any amino acid

<220>
<221>  Z
<222>  (6)..(6)
<223>  Z is I, V or L

<400>  274

Glx Xaa Tyr Xaa Xaa Glx 
1               5       


<210>  275
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 ScFv

<400>  275

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  276
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 ScFv

<400>  276
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtg      720

tcctca                                                                 726


<210>  277
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 ScFv

<400>  277

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Lys Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp 
145                 150                 155                 160 


Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                165                 170                 175     


Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser 
        195                 200                 205             


Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr 
    210                 215                 220                 


Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  278
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 ScFv

<400>  278
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaggtgaa actgcaggag tcaggacctg gcctggtggc gccctcacag      420

agcctgtccg tcacatgcac tgtctcaggg gtctcattac ccgactatgg tgtaagctgg      480

attcgccagc ctccacgaaa gggtctggag tggctgggag taatatgggg tagtgaaacc      540

acatactata attcagctct caaatccaga ctgaccatca tcaaggacaa ctccaagagc      600

caagttttct taaaaatgaa cagtctgcaa actgatgaca cagccattta ctactgtgcc      660

aaacattatt actacggtgg tagctatgct atggactact ggggccaagg aacctcagtc      720

accgtgtcct ca                                                          732


<210>  279
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 CAR

<400>  279

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  280
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 CAR

<400>  280
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtg      720

tcctcaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      780

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      840

gggctggact tcgcctgtga tttctgggtg ctggtcgttg tgggcggcgt gctggcctgc      900

tacagcctgc tggtgacagt ggccttcatc atcttttggg tgaggagcaa gcggagcaga      960

ctgctgcaca gcgactacat gaacatgacc ccccggaggc ctggccccac ccggaagcac     1020

taccagccct acgcccctcc cagggatttc gccgcctacc ggagcaaacg gggcagaaag     1080

aaactcctgt atatattcaa acaaccattt atgaggccag tacaaactac tcaagaggaa     1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1200

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agcgtagagg ccgggaccct     1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1440

aaggggcacg atggccttta ccagggactc agtacagcca ccaaggacac ctacgacgcc     1500

cttcacatgc aggccctgcc ccctcgc                                         1527


<210>  281
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 CAR

<400>  281

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  282
<211>  246
<212>  PRT
<213>  CEA ScFv

<400>  282

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
            180                 185                 190         


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  283
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA ScFv

<400>  283
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

ttcgcttatt acgtggaggc tatggactac tggggccaag ggaccacggt caccgtctcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgatatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtgg gagacagagt caccatcact      480

tgcaaggcca gtcagaatgt gggtactaat gttgcctggt atcagcagaa accagggaaa      540

gcacctaagc tcctgatcta ttcggcatcc taccgctaca gtggagtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

ttcgcaactt actactgtca ccaatattac acctatcctc tattcacgtt tggccagggc      720

accaagctcg agatcaagat ggacatgagg gtccccgctc agctcctggg gctcctgcta      780

ctctggctcc gaggtgccag atgtcaggtg cagctggtgc aatctgggtc tgagttgaag      840

aagcctgggg cctcagtgaa ggtttcctgc aaggcttctg gatacacctt cactgagttt      900

ggaatgaact gggtgcgaca ggcccctgga caagggcttg agtggatggg atggataaac      960

accaaaactg gagaggcaac atatgttgaa gagtttaagg gacggtttgt cttctccttg     1020

gacacctctg tcagcacggc atatctgcag atcagcagcc taaaggctga agacactgcc     1080

gtgtattact gtgcgagatg ggacttcgct tattacgtgg aggctatgga ctactggggc     1140

caagggacca cggtcaccgt ctcctcaggc ggaggtggaa gcggaggggg aggatctggc     1200

ggcggaggaa gcggaggcga tatccagatg acccagtctc catcctccct gtctgcatct     1260

gtgggagaca gagtcaccat cacttgcaag gccagtcaga atgtgggtac taatgttgcc     1320

tggtatcagc agaaaccagg gaaagcacct aagctcctga tctattcggc atcctaccgc     1380

tacagtggag tcccatcaag gttcagtggc agtggatctg ggacagattt cactctcacc     1440

atcagcagtc tgcaacctga agatttcgca acttactact gtcaccaata ttacacctat     1500

cctctattca cgtttggcca gggcaccaag ctcgagatca ag                        1542


<210>  284
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA ScFv

<400>  284

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
            180                 185                 190         


Lys Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  285
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA ScFv

<400>  285
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggagctag tgtgaaggtg       60

tcctgcaagg ccagcggcta caccttcacc gagttcggca tgaactgggt ccgacaggct      120

ccaggccagg gcctcgaatg gatgggctgg atcaacacca agaccggcga ggccacctac      180

gtggaagagt tcaagggcag agtgaccttc accacggaca ccagcaccag caccgcctac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagatgggac      300

ttcgcttatt acgtggaagc catggactac tggggccagg gcaccaccgt gaccgtgtct      360

agcggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgatatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtgg gagacagagt caccatcact      480

tgcaaggcca gtgcggctgt gggtacgtat gttgcgtggt atcagcagaa accagggaaa      540

gcacctaagc tcctgatcta ttcggcatcc taccgcaaaa ggggagtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

ttcgcaactt actactgtca ccaatattac acctatcctc tattcacgtt tggccagggc      720

accaagctcg agatcaag                                                    738


<210>  286
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA ScFv

<400>  286

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala His Tyr Phe Gln Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
            180                 185                 190         


Lys Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  287
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA ScFv

<400>  287
caggtgcagc tggtgcaatc tgggtctgag ttgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact gagtttggaa tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg ataaacacca aaactggaga ggcaacatat      180

gttgaagagt ttaagggacg gtttgtcttc tccttggaca cctctgtcag cacggcatat      240

ctgcagatca gcagcctaaa ggctgaagac actgccgtgt attactgtgc gagatgggac      300

tttgctcatt actttcagac tatggactac tggggccaag ggaccacggt caccgtctcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgatatc      420

cagatgaccc agtctccatc ctccctgtct gcatctgtgg gagacagagt caccatcact      480

tgcaaggcca gtgcggctgt gggtacgtat gttgcgtggt atcagcagaa accagggaaa      540

gcacctaagc tcctgatcta ttcggcatcc taccgcaaaa ggggagtccc atcaaggttc      600

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

ttcgcaactt actactgtca ccaatattac acctatcctc tattcacgtt tggccagggc      720

accaagctcg agatcaag                                                    738


<210>  288
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CAR

<400>  288

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Phe Gly Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala 
65                  70                  75                  80  


Thr Tyr Val Glu Glu Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                245                 250                 255     


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
    370                 375                 380                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
385                 390                 395                 400 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                405                 410                 415     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            420                 425                 430         


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        435                 440                 445             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    450                 455                 460                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg 
    530                 535 


<210>  289
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA CAR

<400>  289
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctggt gcaatctggg tctgagttga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactgagt ttggaatgaa ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggataa acaccaaaac tggagaggca      240

acatatgttg aagagtttaa gggacggttt gtcttctcct tggacacctc tgtcagcacg      300

gcatatctgc agatcagcag cctaaaggct gaagacactg ccgtgtatta ctgtgcgaga      360

tgggacttcg cttattacgt ggaggctatg gactactggg gccaagggac cacggtcacc      420

gtctcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      540

atcacttgca aggccagtca gaatgtgggt actaatgttg cctggtatca gcagaaacca      600

gggaaagcac ctaagctcct gatctattcg gcatcctacc gctacagtgg agtcccatca      660

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      780

cagggcacca agctcgagat caagacaacg acgccagctc cccgcccgcc aacccctgca      840

cctacgattg catcacaacc gctgtccctg cggcctgaag cttgtcgccc agccgcaggt      900

ggcgccgtac atacacgggg gctggatttt gcctgtgatt tctgggtgct ggtcgttgtg      960

ggcggcgtgc tggcctgcta cagcctgctg gtgacagtgg ccttcatcat cttttgggtg     1020

aggagcaagc ggagtcgact gctgcacagc gactacatga acatgacccc ccggaggcct     1080

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg     1140

agcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gaggccagta     1200

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1260

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1320

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1380

cgtagaggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1440

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1500

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggactcag tacagccacc     1560

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctag                  1608


<210>  290
<211>  537
<212>  PRT
<213>  CEA CAR

<400>  290

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Phe Gly Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala 
65                  70                  75                  80  


Thr Tyr Val Glu Glu Phe Lys Gly Arg Val Thr Phe Thr Thr Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                245                 250                 255     


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val 
305                 310                 315                 320 


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
                325                 330                 335     


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
    370                 375                 380                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
385                 390                 395                 400 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                405                 410                 415     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            420                 425                 430         


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        435                 440                 445             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    450                 455                 460                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
465                 470                 475                 480 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                485                 490                 495     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            500                 505                 510         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        515                 520                 525             


Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535         


<210>  291
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA CAR

<400>  291
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctggt gcagtctggc gccgaagtga agaaacctgg agctagtgtg      120

aaggtgtcct gcaaggccag cggctacacc ttcaccgagt tcggcatgaa ctgggtccga      180

caggctccag gccagggcct cgaatggatg ggctggatca acaccaagac cggcgaggcc      240

acctacgtgg aagagttcaa gggcagagtg accttcacca cggacaccag caccagcacc      300

gcctacatgg aactgcggag cctgagaagc gacgacaccg ccgtgtacta ctgcgccaga      360

tgggacttcg cttattacgt ggaagccatg gactactggg gccagggcac caccgtgacc      420

gtgtctagcg gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      540

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      600

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      660

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      780

cagggcacca agctcgagat caagcgtacg acaacgacgc cagctccccg cccgccaacc      840

cctgcaccta cgattgcatc acaaccgctg tccctgcggc ctgaagcttg tcgcccagcc      900

gcaggtggcg ccgtacatac acgggggctg gattttgcct gtgatttctg ggtgctggtc      960

gttgtgggcg gcgtgctggc ctgctacagc ctgctggtga cagtggcctt catcatcttt     1020

tgggtgagga gcaagcggag tcgactgctg cacagcgact acatgaacat gaccccccgg     1080

aggcctggcc ccacccggaa gcactaccag ccctacgccc ctcccaggga tttcgccgcc     1140

taccggagca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgagg     1200

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1260

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1320

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1380

gacaagcgta gaggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1440

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1500

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg actcagtaca     1560

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctag           1614


<210>  292
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CAR

<400>  292

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Phe Gly Met Asn Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala 
65                  70                  75                  80  


Thr Tyr Val Glu Glu Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asp Phe Ala His Tyr Phe Gln 
        115                 120                 125             


Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                245                 250                 255     


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
    370                 375                 380                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
385                 390                 395                 400 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                405                 410                 415     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            420                 425                 430         


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        435                 440                 445             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    450                 455                 460                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
465                 470                 475                 480 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                485                 490                 495     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            500                 505                 510         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        515                 520                 525             


His Met Gln Ala Leu Pro Pro Arg 
    530                 535     


<210>  293
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA CAR

<400>  293
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctggt gcaatctggg tctgagttga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactgagt ttggaatgaa ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggataa acaccaaaac tggagaggca      240

acatatgttg aagagtttaa gggacggttt gtcttctcct tggacacctc tgtcagcacg      300

gcatatctgc agatcagcag cctaaaggct gaagacactg ccgtgtatta ctgtgcgaga      360

tgggactttg ctcattactt tcagactatg gactactggg gccaagggac cacggtcacc      420

gtctcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gatatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc      540

atcacttgca aggccagtgc ggctgtgggt acgtatgttg cgtggtatca gcagaaacca      600

gggaaagcac ctaagctcct gatctattcg gcatcctacc gcaaaagggg agtcccatca      660

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      720

gaagatttcg caacttacta ctgtcaccaa tattacacct atcctctatt cacgtttggc      780

cagggcacca agctcgagat caagcgtaca acgacgccag ctccccgccc gccaacccct      840

gcacctacga ttgcatcaca accgctgtcc ctgcggcctg aagcttgtcg cccagccgca      900

ggtggcgccg tacatacacg ggggctggat tttgcctgtg atttctgggt gctggtcgtt      960

gtgggcggcg tgctggcctg ctacagcctg ctggtgacag tggccttcat catcttttgg     1020

gtgaggagca agcggagtcg actgctgcac agcgactaca tgaacatgac cccccggagg     1080

cctggcccca cccggaagca ctaccagccc tacgcccctc ccagggattt cgccgcctac     1140

cggagcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgaggcca     1200

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1260

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     1320

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1380

aagcgtagag gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1440

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1500

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggact cagtacagcc     1560

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta g              1611


<210>  294
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-H1

<400>  294

Glu Phe Gly Met Asn 
1               5   


<210>  295
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-H2

<400>  295

Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  296
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-H3

<400>  296

Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr 
1               5                   10          


<210>  297
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-H3

<400>  297

Trp Asp Phe Ala His Tyr Phe Gln Thr Met Asp Tyr 
1               5                   10          


<210>  298
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-L1

<400>  298

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  299
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-L1

<400>  299

Lys Ala Ser Ala Ala Val Gly Thr Tyr Val Ala 
1               5                   10      


<210>  300
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-L2

<400>  300

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-L2

<400>  301

Ser Ala Ser Tyr Arg Lys Arg 
1               5           


<210>  302
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CDR-L3

<400>  302

His Gln Tyr Tyr Thr Tyr Pro Leu Phe Thr 
1               5                   10  


<210>  303
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-CYBA-1Y peptide


<220>
<221>  X
<222>  (10)..(10)
<223>  X is Y or H

<400>  303

Ser Thr Met Glu Arg Trp Gly Gln Lys Xaa 
1               5                   10  


<210>  304
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-OAS1-1R


<220>
<221>  X
<222>  (7)..(7)
<223>  X is R or T

<400>  304

Glu Thr Asp Asp Pro Arg Xaa Tyr Gln Lys Tyr 
1               5                   10      


<210>  305
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-2 peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is V or M

<400>  305

Tyr Ile Gly Glu Val Leu Val Ser Xaa 
1               5                   


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-8 peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is R or P

<400>  306

Xaa Thr Leu Asp Lys Val Leu Glu Val 
1               5                   


<210>  307
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-3 peptide


<220>
<221>  X
<222>  (2)..(2)
<223>  X is T or M

<400>  307

Val Xaa Glu Pro Gly Thr Ala Gln Tyr 
1               5                   


<210>  308
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HwA11-S peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is S or T

<400>  308

Cys Ile Pro Pro Asp Xaa Leu Leu Phe Pro Ala 
1               5                   10      


<210>  309
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ADIR-1F peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is F or S

<400>  309

Ser Val Ala Pro Ala Leu Ala Leu Xaa Pro Ala 
1               5                   10      


<210>  310
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-HIVEP1-1S peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is S or N

<400>  310

Ser Leu Pro Lys His Xaa Val Thr Ile 
1               5                   


<210>  311
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NISCH-1A peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is A or V

<400>  311

Ala Leu Ala Pro Ala Pro Xaa Glu Val 
1               5                   


<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-SSR1-1S peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is S or L

<400>  312

Xaa Leu Ala Val Ala Gln Asp Leu Thr 
1               5                   


<210>  313
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-WNK1-1I peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is I or M

<400>  313

Arg Thr Leu Ser Pro Glu Xaa Ile Thr Val 
1               5                   10  


<210>  314
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4A peptide


<220>
<221>  X
<222>  (10)..(10)
<223>  X is A or E

<400>  314

Gly Leu Tyr Thr Tyr Trp Ser Ala Gly Xaa 
1               5                   10  


<210>  315
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTA2-1 peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is L or P

<400>  315

Gln Leu Xaa Asn Ser Val Leu Thr Leu 
1               5                   


<210>  316
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-CLYBL-1Y peptide


<220>
<221>  X
<222>  (5)..(5)
<223>  X is Y or D

<400>  316

Ser Leu Ala Ala Xaa Ile Pro Arg Leu 
1               5                   


<210>  317
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIM22 peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is C or R

<400>  317

Met Ala Val Pro Pro Cys Xaa Ile Gly Val 
1               5                   10  


<210>  318
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PARP10-1L peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is L or P

<400>  318

Gly Leu Xaa Gly Gln Glu Gly Leu Val Glu Ile 
1               5                   10      


<210>  319
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM119A-1T peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is T or I

<400>  319

Ala Met Leu Glu Arg Gln Phe Xaa Val 
1               5                   


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRX3-1S peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is S or P

<400>  320

Phe Leu Xaa Ser Ala Asn Glu His Leu 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNF4G-1M peptide


<220>
<221>  X
<222>  (2)..(2)
<223>  X is M or I

<400>  321

Met Xaa Tyr Lys Asp Ile Leu Leu Leu 
1               5                   


<210>  322
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMMR-1V peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is V or A

<400>  322

Ser Leu Gln Glu Lys Xaa Ala Lys Ala 
1               5                   


<210>  323
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2A1 peptide


<220>
<221>  X
<222>  (4)..(4)
<223>  X is N or K

<400>  323

Val Leu Gln Xaa Val Ala Phe Ser Val 
1               5                   


<210>  324
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC26-1F peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is F or S

<400>  324

Xaa Val Ala Gly Thr Gln Glu Val Phe Val 
1               5                   10  


<210>  325
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3F-1S/A peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is S or A

<400>  325

Phe Leu Xaa Glu His Pro Asn Val Thr Leu 
1               5                   10  


<210>  326
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PRCP-1D peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is D or E

<400>  326

Phe Met Trp Asp Val Ala Glu Xaa Leu 
1               5                   


<210>  327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PRCP-1D peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is D or E

<400>  327

Phe Met Trp Asp Val Ala Glu Xaa Leu Lys Ala 
1               5                   10      


<210>  328
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-CCL4-1T peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is T or S

<400>  328

Cys Ala Asp Pro Ser Glu Xaa Trp Val 
1               5                   


<210>  329
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NCAPD3-1Q peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is Q or R

<400>  329

Trp Leu Xaa Gly Val Val Pro Val Val 
1               5                   


<210>  330
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NDC80-1P peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is P or A

<400>  330

His Leu Glu Glu Gln Ile Xaa Lys Val 
1               5                   


<210>  331
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TTK-1D peptide


<220>
<221>  X
<222>  (4)..(4)
<223>  X is D or E

<400>  331

Arg Leu His Xaa Gly Arg Val Phe Val 
1               5                   


<210>  332
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WDR27-1L peptide


<220>
<221>  X
<222>  (2)..(2)
<223>  X is L or P

<400>  332

Ser Xaa Asp Asp His Val Val Ala Val 
1               5                   


<210>  333
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIIP peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is K or E

<400>  333

Ser Glu Glu Ser Ala Val Pro Xaa Arg Ser Trp 
1               5                   10      


<210>  334
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIIP peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is K or E

<400>  334

Glu Glu Ser Ala Val Pro Xaa Arg Ser Trp 
1               5                   10  


<210>  335
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-DHX33-1C peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is C or R

<400>  335

Tyr Leu Tyr Glu Gly Gly Ile Ser Xaa 
1               5                   


<210>  336
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PANE1 peptide

<400>  336

Arg Val Trp Asp Leu Pro Gly Val Leu Lys 
1               5                   10  


<210>  337
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP110 peptide


<220>
<221>  X
<222>  (4)..(4)
<223>  X is R or G

<400>  337

Ser Leu Pro Xaa Gly Thr Ser Thr Pro Lys 
1               5                   10  


<210>  338
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-1C/Y


<220>
<221>  X
<222>  (5)..(5)
<223>  X is Y or C

<400>  338

Asp Tyr Leu Gln Xaa Val Leu Gln Ile 
1               5                   


<210>  339
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2RX7 peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is H or R

<400>  339

Trp Phe His His Cys Xaa Pro Lys Tyr 
1               5                   


<210>  340
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-4 peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is R or G

<400>  340

Ala Thr Leu Pro Leu Leu Cys Ala Xaa 
1               5                   


<210>  341
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-5


<220>
<221>  X
<222>  (10)..(10)
<223>  X is R or G

<400>  341

Trp Ala Thr Leu Pro Leu Leu Cys Ala Xaa 
1               5                   10  


<210>  342
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP13 peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is M or T

<400>  342

Ala Pro Ala Gly Val Arg Glu Val Xaa 
1               5                   


<210>  343
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-APOBEC3B-1K peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is K or E

<400>  343

Xaa Pro Gln Tyr His Ala Glu Met Cys Phe 
1               5                   10  


<210>  344
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3H peptide


<220>
<221>  X
<222>  (5)..(5)
<223>  X is K or E

<400>  344

Lys Pro Gln Gln Xaa Gly Leu Arg Leu 
1               5                   


<210>  345
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ARHGDIB-1R peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is R or P

<400>  345

Pro Arg Ala Cys Trp Xaa Glu Ala 
1               5               


<210>  346
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-BCAT2-1R peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is R or T

<400>  346

Gln Pro Xaa Arg Ala Leu Leu Phe Val Ile 
1               5                   10  


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFAR peptide


<220>
<221>  X
<222>  (11)..(11)
<223>  X is M or R

<400>  347

Ala Pro Asn Thr Gly Arg Ala Asn Gln Gln Xaa 
1               5                   10      


<210>  348
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C14orf169 peptide


<220>
<221>  X
<222>  (4)..(4)
<223>  X is A or V

<400>  348

Arg Pro Arg Xaa Pro Thr Glu Glu Leu Ala Leu 
1               5                   10      


<210>  349
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-C16ORF-1R peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is R or W

<400>  349

Xaa Pro Cys Pro Ser Val Gly Leu Ser Phe Leu 
1               5                   10      


<210>  350
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C18orf21 peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is A or T

<400>  350

Asn Pro Ala Thr Pro Xaa Ser Lys Leu 
1               5                   


<210>  351
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-EBI3-1I peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is I or V

<400>  351

Arg Pro Arg Ala Arg Tyr Tyr Xaa Gln Val 
1               5                   10  


<210>  352
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP1 peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is N or K

<400>  352

Leu Pro Gln Lys Lys Ser Xaa Ala Leu 
1               5                   


<210>  353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCRIB peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is L or P

<400>  353

Leu Pro Gln Gln Pro Pro Xaa Ser Leu 
1               5                   


<210>  354
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTRR peptide


<220>
<221>  X
<222>  (5)..(5)
<223>  X is S or L

<400>  354

Ser Pro Ala Ser Xaa Arg Thr Asp Leu 
1               5                   


<210>  355
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LLGL2


<220>
<221>  X
<222>  (5)..(5)
<223>  X is R or H

<400>  355

Ser Pro Ser Leu Xaa Ile Leu Ala Ile 
1               5                   


<210>  356
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ECGF-1H peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is H or R

<400>  356

Arg Pro Xaa Ala Ile Arg Arg Pro Leu Ala Leu 
1               5                   10      


<210>  357
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ERAP1-1R peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is R or P

<400>  357

His Pro Xaa Gln Glu Gln Ile Ala Leu Leu Ala 
1               5                   10      


<210>  358
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ERAP1-1R peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is R or P

<400>  358

His Pro Xaa Gln Glu Gln Ile Ala Leu 
1               5                   


<210>  359
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-FUCA2-1V peptide


<220>
<221>  X
<222>  (5)..(5)
<223>  X is V or M

<400>  359

Arg Leu Arg Gln Xaa Gly Ser Trp Leu 
1               5                   


<210>  360
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-GEMIN4-1V peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is V or E

<400>  360

Phe Pro Ala Leu Arg Phe Val Glu Xaa 
1               5                   


<210>  361
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDGF peptide


<220>
<221>  X
<222>  (11)..(11)
<223>  X is L or P

<400>  361

Leu Pro Met Glu Val Glu Lys Asn Ser Thr Xaa 
1               5                   10      


<210>  362
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PDCD11-1F peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is F or L

<400>  362

Gly Pro Asp Ser Ser Lys Thr Xaa Leu Cys Leu 
1               5                   10      


<210>  363
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PFAS-1P peptide


<220>
<221>  X
<222>  (2)..(2)
<223>  X is P or S

<400>  363

Ala Xaa Gly His Thr Arg Arg Lys Leu 
1               5                   


<210>  364
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TEP1-1S peptide


<220>
<221>  X
<222>  (9)..(9)
<223>  X is S or P

<400>  364

Ala Pro Asp Gly Ala Lys Val Ala Xaa Leu 
1               5                   10  


<210>  365
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TMEM8A-1I peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is I or V

<400>  365

Arg Pro Arg Ser Val Thr Xaa Gln Pro Leu Leu 
1               5                   10      


<210>  366
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-USP15-1I peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is I or T

<400>  366

Met Pro Ser His Leu Arg Asn Xaa Leu Leu 
1               5                   10  


<210>  367
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LRH-1 peptide

<400>  367

Thr Pro Asn Gln Arg Gln Asn Val Cys 
1               5                   


<210>  368
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-MOB3A-1C peptide


<220>
<221>  X
<222>  (1)..(1)
<223>  X is C or S

<400>  368

Xaa Pro Arg Pro Gly Thr Trp Thr Cys 
1               5                   


<210>  369
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ZDHHC6-1Y peptide


<220>
<221>  X
<222>  (4)..(4)
<223>  X is Y or H

<400>  369

Arg Pro Arg Xaa Trp Ile Leu Leu Val Lys Ile 
1               5                   10      


<210>  370
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZAPHIR peptide

<400>  370

Ile Pro Arg Asp Ser Trp Trp Val Glu Leu 
1               5                   10  


<210>  371
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR1 peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is E or G

<400>  371

Ile Ser Lys Glu Arg Ala Xaa Ala Leu 
1               5                   


<210>  372
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-GSTP1-1V peptide


<220>
<221>  X
<222>  (7)..(7)
<223>  X is V or I

<400>  372

Asp Leu Arg Cys Lys Tyr Xaa Ser Leu 
1               5                   


<210>  373
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1/B60 peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is H or R

<400>  373

Lys Glu Cys Val Leu Xaa Asp Asp Leu 
1               5                   


<210>  374
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-SON-1R peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is R or C

<400>  374

Ser Glu Thr Lys Gln Xaa Thr Val Leu 
1               5                   


<210>  375
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-SWAP70-1Q peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is Q or E

<400>  375

Met Glu Gln Leu Glu Xaa Leu Glu Leu 
1               5                   


<210>  376
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TRIP10-1EPC peptide


<220>
<221>  X
<222>  (2)..(2)
<223>  X is E or G

<220>
<221>  X
<222>  (3)..(3)
<223>  X is P or S

<220>
<221>  X
<222>  (7)..(7)
<223>  X is C or G

<400>  376

Gly Xaa Xaa Gln Asp Leu Xaa Thr Leu 
1               5                   


<210>  377
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NUP133-1R peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is R or Q

<400>  377

Ser Glu Asp Leu Ile Leu Cys Xaa Leu 
1               5                   


<210>  378
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ZNFX1-1Q peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is Q or H

<400>  378

Asn Glu Ile Glu Asp Val Trp Xaa Leu Asp Leu 
1               5                   10      


<210>  379
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLC1A5 peptide


<220>
<221>  X
<222>  (3)..(3)
<223>  X is A or P

<400>  379

Ala Glu Xaa Thr Ala Asn Gly Gly Leu Ala Leu 
1               5                   10      


<210>  380
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-2 peptide


<220>
<221>  X
<222>  (6)..(6)
<223>  X is D or G

<400>  380

Lys Glu Phe Glu Asp Xaa Ile Ile Asn Trp 
1               5                   10  


<210>  381
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-6 peptide

<400>  381

Met Glu Ile Phe Ile Glu Val Phe Ser His Phe 
1               5                   10      


<210>  382
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HB-1H/Y peptide


<220>
<221>  X
<222>  (8)..(8)
<223>  X is H or Y

<400>  382

Glu Glu Lys Arg Gly Ser Leu Xaa Val Trp 
1               5                   10  


<210>  383
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPH1 peptide


<220>
<221>  X
<222>  (2)..(2)
<223>  X is V or L

<400>  383

Ser Xaa Leu Pro Glu Val Asp Val Trp 
1               5                   


<210>  384
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT2B17/A02 peptide

<400>  384

Cys Val Ala Thr Met Ile Phe Met Ile 
1               5                   


<210>  385
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT2B17/A29

<400>  385

Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr 
1               5                   10  


<210>  386
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT2B17/B44 peptide

<400>  386

Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr 
1               5                   10  


<210>  387
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFFRY peptide


<220>
<221>  X
<222>  (4)..(4)
<223>  X is C or S

<400>  387

Ile Val Asp Xaa Leu Thr Glu Met Tyr 
1               5                   


<210>  388
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SMCY peptide

<400>  388

Phe Ile Asp Ser Tyr Ile Cys Gln Val 
1               5                   


<210>  389
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMSB4Y peptide

<400>  389

Glu Val Leu Leu Arg Pro Gly Leu His Phe Arg 
1               5                   10      


<210>  390
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 CAR

<400>  390
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaggtgaa actgcaggag tcaggacctg gcctggtggc gccctcacag      420

agcctgtccg tcacatgcac tgtctcaggg gtctcattac ccgactatgg tgtaagctgg      480

attcgccagc ctccacgaaa gggtctggag tggctgggag taatatgggg tagtgaaacc      540

acatactata attcagctct caaatccaga ctgaccatca tcaaggacaa ctccaagagc      600

caagttttct taaaaatgaa cagtctgcaa actgatgaca cagccattta ctactgtgcc      660

aaacattatt actacggtgg tagctatgct atggactact ggggccaagg aacctcagtc      720

accgtgtcct caaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      780

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      840

acgagggggc tggacttcgc ctgtgatttc tgggtgctgg tcgttgtggg cggcgtgctg      900

gcctgctaca gcctgctggt gacagtggcc ttcatcatct tttgggtgag gagcaagcgg      960

agcagactgc tgcacagcga ctacatgaac atgacccccc ggaggcctgg ccccacccgg     1020

aagcactacc agccctacgc ccctcccagg gatttcgccg cctaccggag caaacggggc     1080

agaaagaaac tcctgtatat attcaaacaa ccatttatga ggccagtaca aactactcaa     1140

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1200

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1260

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagcg tagaggccgg     1320

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1380

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1440

aggggcaagg ggcacgatgg cctttaccag ggactcagta cagccaccaa ggacacctac     1500

gacgcccttc acatgcaggc cctgccccct cgc                                  1533


<210>  391
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR ScFv

<400>  391

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
            180                 185                 190         


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Ala Glu Ile Lys 
                245 


