                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  ACTIVATORS OF TYPE III CAS PROTEINS

<130>  51229-0007WO1

<140>  PCT/US2021/051053
<141>  2021-09-20

<150>  63/080,253
<151>  2020-09-18

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator

<400>  1
aaaauuuuuu                                                              10


<210>  2
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) fluoro modified A

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  5-methylcytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  5-methylcytosine

<400>  2
aaaauccccc                                                              10


<210>  3
<211>  60
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 guide

<400>  3
auuuagacca ccccaaaaau gaaggggacu aaaacacaga uauagccugg ugguucaggc       60


<210>  4
<211>  28
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 activator

<400>  4
aaaagccuga accaccaggc uauaucug                                          28


<210>  5
<211>  60
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 guide

<400>  5
uagaccagcc caaaaaugaa gggcacuaaa acgcagcgcc ucuugcaacg auuaaauacu       60


<210>  6
<211>  30
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 activator

<400>  6
aguauuuaau cguugcaaga ggcgcugcuc                                        30


<210>  7
<211>  52
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 guide

<400>  7
uagaccaccc caaaaaugaa ggggacuaaa acguucggac aaagugcaug aa               52


<210>  8
<211>  32
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 activator

<400>  8
uaaagcuuca ugcacuuugu ccgaacaacu gg                                     32


<210>  9
<211>  52
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 guide

<400>  9
uagaccaccc caaaaaugaa ggggacuaaa acgguccacc aaacguaaug cg               52


<210>  10
<211>  52
<212>  RNA
<213>  artificial

<220>
<223>  Cas13 guide

<400>  10
uagaccaccc caaaaaugaa ggggacuaaa acuuugcggc caauguuugu aa               52


<210>  11
<211>  2668
<212>  RNA
<213>  artificial

<220>
<223>  Type IV activator

<400>  11
cagguuacua uagcagagau auuacuaauu auuaugagga cuuuuaaagu uuccauuugg       60

aaucuugauu acaucauaaa ccucauaauu aaaaauuuau cuaagucacu aacugagaau      120

aaauauucuc aauuagauga agagcaacca auggagauug auuaaacgaa caugaaaauu      180

auucuuuucu uggcacugau aacacucgcu acuugugagc uuuaucacua ccaagagugu      240

guuagaggua caacaguacu uuuaaaagaa ccuugcucuu cuggaacaua cgagggcaau      300

ucaccauuuc auccucuagc ugauaacaaa uuugcacuga cuugcuuuag cacucaauuu      360

gcuuuugcuu guccugacgg cguaaaacac gucuaucagu uacgugccag aucaguuuca      420

ccuaaacugu ucaucagaca agaggaaguu caagaacuuu acucuccaau uuuucuuauu      480

guugcggcaa uaguguuuau aacacuuugc uucacacuca aaagaaagac agaaugauug      540

aacuuucauu aauugacuuc uauuugugcu uuuuagccuu ucugcuauuc cuuguuuuaa      600

uuaugcuuau uaucuuuugg uucucacuug aacugcaaga ucauaaugaa acuugucacg      660

ccuaaacgaa caugaaauuu cuuguuuucu uaggaaucau cacaacugua gcugcauuuc      720

accaagaaug uaguuuacag ucauguacuc aacaucaacc auauguaguu gaugacccgu      780

guccuauuca cuucuauucu aaaugguaua uuagaguagg agcuagaaaa ucagcaccuu      840

uaauugaauu gugcguggau gaggcugguu cuaaaucacc cauucaguac aucgauaucg      900

guaauuauac aguuuccugu uuaccuuuua caauuaauug ccaggaaccu aaauugggua      960

gucuuguagu gcguuguucg uucuaugaag acuuuuuaga guaucaugac guucguguug     1020

uuuuagauuu caucuaaacg aacaaacuaa aaugucugau aauggacccc aaaaucagcg     1080

aaaugcaccc cgcauuacgu uugguggacc cucagauuca acuggcagua accagaaugg     1140

agaacgcagu ggggcgcgau caaaacaacg ucggccccaa gguuuaccca auaauacugc     1200

gucuugguuc accgcucuca cucaacaugg caaggaagac cuuaaauucc cucgaggaca     1260

aggcguucca auuaacacca auagcagucc agaugaccaa auuggcuacu accgaagagc     1320

uaccagacga auucguggug gugacgguaa aaugaaagau cucaguccaa gaugguauuu     1380

cuacuaccua ggaacugggc cagaagcugg acuucccuau ggugcuaaca aagacggcau     1440

cauauggguu gcaacugagg gagccuugaa uacaccaaaa gaucacauug gcacccgcaa     1500

uccugcuaac aaugcugcaa ucgugcuaca acuuccucaa ggaacaacau ugccaaaagg     1560

cuucuacgca gaagggagca gaggcggcag ucaagccucu ucucguuccu caucacguag     1620

ucgcaacagu ucaagaaauu caacuccagg cagcaguagg ggaacuucuc cugcuagaau     1680

ggcuggcaau ggcggugaug cugcucuugc uuugcugcug cuugacagau ugaaccagcu     1740

ugagagcaaa augucuggua aaggccaaca acaacaaggc caaacuguca cuaagaaauc     1800

ugcugcugag gcuucuaaga agccucggca aaaacguacu gccacuaaag cauacaaugu     1860

aacacaagcu uucggcagac gugguccaga acaaacccaa ggaaauuuug gggaccagga     1920

acuaaucaga caaggaacug auuacaaaca uuggccgcaa auugcacaau uugcccccag     1980

cgcuucagcg uucuucggaa ugucgcgcau uggcauggaa gucacaccuu cgggaacgug     2040

guugaccuac acaggugcca ucaaauugga ugacaaagau ccaaauuuca aagaucaagu     2100

cauuuugcug aauaagcaua uugacgcaua caaaacauuc ccaccaacag agccuaaaaa     2160

ggacaaaaag aagaaggcug augaaacuca agccuuaccg cagagacaga agaaacagca     2220

aacugugacu cuucuuccug cugcagauuu ggaugauuuc uccaaacaau ugcaacaauc     2280

caugagcagu gcugacucaa cucaggccua aacucaugca gaccacacaa ggcagauggg     2340

cuauauaaac guuuucgcuu uuccguuuac gauauauagu cuacucuugu gcagaaugaa     2400

uucucguaac uacauagcac aaguagaugu aguuaacuuu aaucucacau agcaaucuuu     2460

aaucagugug uaacauuagg gaggacuuga aagagccacc acauuuucac cgaggccacg     2520

cggaguacga ucgaguguac agugaacaau gcuagggaga gcugccuaua uggaagagcc     2580

cuaaugugua aaauuaauuu uaguagugcu auccccaugu gauuuuaaua gcuucuuagg     2640

agaaugacaa aaaaaaaaaa aaaaaaaa                                        2668


<210>  12
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2 (prime) OMe modified A

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) OMe modified A

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2 (prime) OMe modified A

<400>  12
aaaauuuuuu                                                              10


<210>  13
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2 (prime) deoxy modified A

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) deoxy modified A

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2 (prime) deoxy modified A

<400>  13
aaaauuuuuu                                                              10


<210>  14
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) deoxy modified A

<400>  14
aaaauuuuuu                                                              10


<210>  15
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2 (prime) deoxy modified A

<400>  15
aaaauuuuuu                                                              10


<210>  16
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2 (prime) deoxy modified A

<400>  16
aaaauuuuuu                                                              10


<210>  17
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) deoxy modified A

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2 (prime) deoxy modified A

<400>  17
aaaauuuuuu                                                              10


<210>  18
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2 (prime) deoxy modified A

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) deoxy modified A

<400>  18
aaaauuuuuu                                                              10


<210>  19
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2 (prime) fluoro modified A

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) fluoro modified A

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2 (prime) fluoro modified A

<400>  19
aaaauuuuuu                                                              10


<210>  20
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) fluoro modified A

<400>  20
aaaauuuuuu                                                              10


<210>  21
<211>  1389
<212>  PRT
<213>  Leptotrichia shahii

<400>  21

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210>  22
<211>  1152
<212>  PRT
<213>  Leptotrichia wadei

<400>  22

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Ile Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Tyr Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp 
                565                 570                 575     


Ser Val Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Val Phe Phe Lys Ile Thr Asn Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly His Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Glu 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Ile Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Ser Asn Asn Asn Asn Asp Asn Asn Asp Ile 
    690                 695                 700                 


Phe Ser Lys Ile Lys Ile Lys Lys Asp Asn Lys Glu Lys Tyr Asp Lys 
705                 710                 715                 720 


Ile Leu Lys Asn Tyr Glu Lys His Asn Arg Asn Lys Glu Ile Pro His 
                725                 730                 735     


Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys 
            740                 745                 750         


Tyr Thr Glu Asn Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn 
        755                 760                 765             


His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser 
    770                 775                 780                 


Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu 
785                 790                 795                 800 


Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala 
                805                 810                 815     


Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Glu Asn Lys Ile Lys Asp 
            820                 825                 830         


Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly 
        835                 840                 845             


Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly 
    850                 855                 860                 


Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile 
865                 870                 875                 880 


Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu 
                885                 890                 895     


Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro 
            900                 905                 910         


Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys 
        915                 920                 925             


Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu 
    930                 935                 940                 


Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His 
945                 950                 955                 960 


Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg 
                965                 970                 975     


Leu Lys Gly Glu Phe Pro Glu Asn His Tyr Ile Glu Glu Ile Phe Asn 
            980                 985                 990         


Phe Asp Asn Ser Lys Asn Val Lys  Tyr Lys Ser Gly Gln  Ile Val Glu 
        995                 1000                 1005             


Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr Lys Asp  Asn Val Glu 
    1010                 1015                 1020             


Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val Lys Lys  Leu Lys Gln 
    1025                 1030                 1035             


Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr Ile Ala  His Phe Asn 
    1040                 1045                 1050             


Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu Glu Val  Leu Glu Asn 
    1055                 1060                 1065             


Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Ile 
    1070                 1075                 1080             


Met Lys  Ser Ile Val Asp Ile  Leu Lys Glu Tyr Gly  Phe Val Ala 
    1085                 1090                 1095             


Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile Glu Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Ser  Glu Lys Ile Val His  Leu Lys Asn Leu Lys  Lys Lys Lys 
    1115                 1120                 1125             


Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu Cys Glu  Leu Val Lys 
    1130                 1135                 1140             


Val Met  Phe Glu Tyr Lys Ala  Leu Glu 
    1145                 1150         


<210>  23
<211>  1120
<212>  PRT
<213>  Listeria seeligeri

<400>  23

Met Trp Ile Ser Ile Lys Thr Leu Ile His His Leu Gly Val Leu Phe 
1               5                   10                  15      


Phe Cys Asp Tyr Met Tyr Asn Arg Arg Glu Lys Lys Ile Ile Glu Val 
            20                  25                  30          


Lys Thr Met Arg Ile Thr Lys Val Glu Val Asp Arg Lys Lys Val Leu 
        35                  40                  45              


Ile Ser Arg Asp Lys Asn Gly Gly Lys Leu Val Tyr Glu Asn Glu Met 
    50                  55                  60                  


Gln Asp Asn Thr Glu Gln Ile Met His His Lys Lys Ser Ser Phe Tyr 
65                  70                  75                  80  


Lys Ser Val Val Asn Lys Thr Ile Cys Arg Pro Glu Gln Lys Gln Met 
                85                  90                  95      


Lys Lys Leu Val His Gly Leu Leu Gln Glu Asn Ser Gln Glu Lys Ile 
            100                 105                 110         


Lys Val Ser Asp Val Thr Lys Leu Asn Ile Ser Asn Phe Leu Asn His 
        115                 120                 125             


Arg Phe Lys Lys Ser Leu Tyr Tyr Phe Pro Glu Asn Ser Pro Asp Lys 
    130                 135                 140                 


Ser Glu Glu Tyr Arg Ile Glu Ile Asn Leu Ser Gln Leu Leu Glu Asp 
145                 150                 155                 160 


Ser Leu Lys Lys Gln Gln Gly Thr Phe Ile Cys Trp Glu Ser Phe Ser 
                165                 170                 175     


Lys Asp Met Glu Leu Tyr Ile Asn Trp Ala Glu Asn Tyr Ile Ser Ser 
            180                 185                 190         


Lys Thr Lys Leu Ile Lys Lys Ser Ile Arg Asn Asn Arg Ile Gln Ser 
        195                 200                 205             


Thr Glu Ser Arg Ser Gly Gln Leu Met Asp Arg Tyr Met Lys Asp Ile 
    210                 215                 220                 


Leu Asn Lys Asn Lys Pro Phe Asp Ile Gln Ser Val Ser Glu Lys Tyr 
225                 230                 235                 240 


Gln Leu Glu Lys Leu Thr Ser Ala Leu Lys Ala Thr Phe Lys Glu Ala 
                245                 250                 255     


Lys Lys Asn Asp Lys Glu Ile Asn Tyr Lys Leu Lys Ser Thr Leu Gln 
            260                 265                 270         


Asn His Glu Arg Gln Ile Ile Glu Glu Leu Lys Glu Asn Ser Glu Leu 
        275                 280                 285             


Asn Gln Phe Asn Ile Glu Ile Arg Lys His Leu Glu Thr Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Lys Val Gly Asp Ile Arg Asn Leu Glu Ile 
305                 310                 315                 320 


Gly Glu Ile Gln Lys Ile Val Asn His Arg Leu Lys Asn Lys Ile Val 
                325                 330                 335     


Gln Arg Ile Leu Gln Glu Gly Lys Leu Ala Ser Tyr Glu Ile Glu Ser 
            340                 345                 350         


Thr Val Asn Ser Asn Ser Leu Gln Lys Ile Lys Ile Glu Glu Ala Phe 
        355                 360                 365             


Ala Leu Lys Phe Ile Asn Ala Cys Leu Phe Ala Ser Asn Asn Leu Arg 
    370                 375                 380                 


Asn Met Val Tyr Pro Val Cys Lys Lys Asp Ile Leu Met Ile Gly Glu 
385                 390                 395                 400 


Phe Lys Asn Ser Phe Lys Glu Ile Lys His Lys Lys Phe Ile Arg Gln 
                405                 410                 415     


Trp Ser Gln Phe Phe Ser Gln Glu Ile Thr Val Asp Asp Ile Glu Leu 
            420                 425                 430         


Ala Ser Trp Gly Leu Arg Gly Ala Ile Ala Pro Ile Arg Asn Glu Ile 
        435                 440                 445             


Ile His Leu Lys Lys His Ser Trp Lys Lys Phe Phe Asn Asn Pro Thr 
    450                 455                 460                 


Phe Lys Val Lys Lys Ser Lys Ile Ile Asn Gly Lys Thr Lys Asp Val 
465                 470                 475                 480 


Thr Ser Glu Phe Leu Tyr Lys Glu Thr Leu Phe Lys Asp Tyr Phe Tyr 
                485                 490                 495     


Ser Glu Leu Asp Ser Val Pro Glu Leu Ile Ile Asn Lys Met Glu Ser 
            500                 505                 510         


Ser Lys Ile Leu Asp Tyr Tyr Ser Ser Asp Gln Leu Asn Gln Val Phe 
        515                 520                 525             


Thr Ile Pro Asn Phe Glu Leu Ser Leu Leu Thr Ser Ala Val Pro Phe 
    530                 535                 540                 


Ala Pro Ser Phe Lys Arg Val Tyr Leu Lys Gly Phe Asp Tyr Gln Asn 
545                 550                 555                 560 


Gln Asp Glu Ala Gln Pro Asp Tyr Asn Leu Lys Leu Asn Ile Tyr Asn 
                565                 570                 575     


Glu Lys Ala Phe Asn Ser Glu Ala Phe Gln Ala Gln Tyr Ser Leu Phe 
            580                 585                 590         


Lys Met Val Tyr Tyr Gln Val Phe Leu Pro Gln Phe Thr Thr Asn Asn 
        595                 600                 605             


Asp Leu Phe Lys Ser Ser Val Asp Phe Ile Leu Thr Leu Asn Lys Glu 
    610                 615                 620                 


Arg Lys Gly Tyr Ala Lys Ala Phe Gln Asp Ile Arg Lys Met Asn Lys 
625                 630                 635                 640 


Asp Glu Lys Pro Ser Glu Tyr Met Ser Tyr Ile Gln Ser Gln Leu Met 
                645                 650                 655     


Leu Tyr Gln Lys Lys Gln Glu Glu Lys Glu Lys Ile Asn His Phe Glu 
            660                 665                 670         


Lys Phe Ile Asn Gln Val Phe Ile Lys Gly Phe Asn Ser Phe Ile Glu 
        675                 680                 685             


Lys Asn Arg Leu Thr Tyr Ile Cys His Pro Thr Lys Asn Thr Val Pro 
    690                 695                 700                 


Glu Asn Asp Asn Ile Glu Ile Pro Phe His Thr Asp Met Asp Asp Ser 
705                 710                 715                 720 


Asn Ile Ala Phe Trp Leu Met Cys Lys Leu Leu Asp Ala Lys Gln Leu 
                725                 730                 735     


Ser Glu Leu Arg Asn Glu Met Ile Lys Phe Ser Cys Ser Leu Gln Ser 
            740                 745                 750         


Thr Glu Glu Ile Ser Thr Phe Thr Lys Ala Arg Glu Val Ile Gly Leu 
        755                 760                 765             


Ala Leu Leu Asn Gly Glu Lys Gly Cys Asn Asp Trp Lys Glu Leu Phe 
    770                 775                 780                 


Asp Asp Lys Glu Ala Trp Lys Lys Asn Met Ser Leu Tyr Val Ser Glu 
785                 790                 795                 800 


Glu Leu Leu Gln Ser Leu Pro Tyr Thr Gln Glu Asp Gly Gln Thr Pro 
                805                 810                 815     


Val Ile Asn Arg Ser Ile Asp Leu Val Lys Lys Tyr Gly Thr Glu Thr 
            820                 825                 830         


Ile Leu Glu Lys Leu Phe Ser Ser Ser Asp Asp Tyr Lys Val Ser Ala 
        835                 840                 845             


Lys Asp Ile Ala Lys Leu His Glu Tyr Asp Val Thr Glu Lys Ile Ala 
    850                 855                 860                 


Gln Gln Glu Ser Leu His Lys Gln Trp Ile Glu Lys Pro Gly Leu Ala 
865                 870                 875                 880 


Arg Asp Ser Ala Trp Thr Lys Lys Tyr Gln Asn Val Ile Asn Asp Ile 
                885                 890                 895     


Ser Asn Tyr Gln Trp Ala Lys Thr Lys Val Glu Leu Thr Gln Val Arg 
            900                 905                 910         


His Leu His Gln Leu Thr Ile Asp Leu Leu Ser Arg Leu Ala Gly Tyr 
        915                 920                 925             


Met Ser Ile Ala Asp Arg Asp Phe Gln Phe Ser Ser Asn Tyr Ile Leu 
    930                 935                 940                 


Glu Arg Glu Asn Ser Glu Tyr Arg Val Thr Ser Trp Ile Leu Leu Ser 
945                 950                 955                 960 


Glu Asn Lys Asn Lys Asn Lys Tyr Asn Asp Tyr Glu Leu Tyr Asn Leu 
                965                 970                 975     


Lys Asn Ala Ser Ile Lys Val Ser Ser Lys Asn Asp Pro Gln Leu Lys 
            980                 985                 990         


Val Asp Leu Lys Gln Leu Arg Leu  Thr Leu Glu Tyr Leu  Glu Leu Phe 
        995                 1000                 1005             


Asp Asn  Arg Leu Lys Glu Lys  Arg Asn Asn Ile Ser  His Phe Asn 
    1010                 1015                 1020             


Tyr Leu  Asn Gly Gln Leu Gly  Asn Ser Ile Leu Glu  Leu Phe Asp 
    1025                 1030                 1035             


Asp Ala  Arg Asp Val Leu Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1040                 1045                 1050             


Val Ser  Lys Ser Leu Lys Glu  Ile Leu Ser Ser His  Gly Met Glu 
    1055                 1060                 1065             


Val Thr  Phe Lys Pro Leu Tyr  Gln Thr Asn His His  Leu Lys Ile 
    1070                 1075                 1080             


Asp Lys  Leu Gln Pro Lys Lys  Ile His His Leu Gly  Glu Lys Ser 
    1085                 1090                 1095             


Thr Val  Ser Ser Asn Gln Val  Ser Asn Glu Tyr Cys  Gln Leu Val 
    1100                 1105                 1110             


Arg Thr  Leu Leu Thr Met Lys  
    1115                 1120 


<210>  24
<211>  1340
<212>  PRT
<213>  artificial

<220>
<223>  synthetic CasA polypeptide

<400>  24

Met Gln Ile Ser Lys Val Asn His Lys His Val Ala Val Gly Gln Lys 
1               5                   10                  15      


Asp Arg Glu Arg Ile Thr Gly Phe Ile Tyr Asn Asp Pro Val Gly Asp 
            20                  25                  30          


Glu Lys Ser Leu Glu Asp Val Val Ala Lys Arg Ala Asn Asp Thr Lys 
        35                  40                  45              


Val Leu Phe Asn Val Phe Asn Thr Lys Asp Leu Tyr Asp Ser Gln Glu 
    50                  55                  60                  


Ser Asp Lys Ser Glu Lys Asp Lys Glu Ile Ile Ser Lys Gly Ala Lys 
65                  70                  75                  80  


Phe Val Ala Lys Ser Phe Asn Ser Ala Ile Thr Ile Leu Lys Lys Gln 
                85                  90                  95      


Asn Lys Ile Tyr Ser Thr Leu Thr Ser Gln Gln Val Ile Lys Glu Leu 
            100                 105                 110         


Lys Asp Lys Phe Gly Gly Ala Arg Ile Tyr Asp Asp Asp Ile Glu Glu 
        115                 120                 125             


Ala Leu Thr Glu Thr Leu Lys Lys Ser Phe Arg Lys Glu Asn Val Arg 
    130                 135                 140                 


Asn Ser Ile Lys Val Leu Ile Glu Asn Ala Ala Gly Ile Arg Ser Ser 
145                 150                 155                 160 


Leu Ser Lys Asp Glu Glu Glu Leu Ile Gln Glu Tyr Phe Val Lys Gln 
                165                 170                 175     


Leu Val Glu Glu Tyr Thr Lys Thr Lys Leu Gln Lys Asn Val Val Lys 
            180                 185                 190         


Ser Ile Lys Asn Gln Asn Met Val Ile Gln Pro Asp Ser Asp Ser Gln 
        195                 200                 205             


Val Leu Ser Leu Ser Glu Ser Arg Arg Glu Lys Gln Ser Ser Ala Val 
    210                 215                 220                 


Ser Ser Asp Thr Leu Val Asn Cys Lys Glu Lys Asp Val Leu Lys Ala 
225                 230                 235                 240 


Phe Leu Thr Asp Tyr Ala Val Leu Asp Glu Asp Glu Arg Asn Ser Leu 
                245                 250                 255     


Leu Trp Lys Leu Arg Asn Leu Val Asn Leu Tyr Phe Tyr Gly Ser Glu 
            260                 265                 270         


Ser Ile Arg Asp Tyr Ser Tyr Thr Lys Glu Lys Ser Val Trp Lys Glu 
        275                 280                 285             


His Asp Glu Gln Lys Ala Asn Lys Thr Leu Phe Ile Asp Glu Ile Cys 
    290                 295                 300                 


His Ile Thr Lys Ile Gly Lys Asn Gly Lys Glu Gln Lys Val Leu Asp 
305                 310                 315                 320 


Tyr Glu Glu Asn Arg Ser Arg Cys Arg Lys Gln Asn Ile Asn Tyr Tyr 
                325                 330                 335     


Arg Ser Ala Leu Asn Tyr Ala Lys Asn Asn Thr Ser Gly Ile Phe Glu 
            340                 345                 350         


Asn Glu Asp Ser Asn His Phe Trp Ile His Leu Ile Glu Asn Glu Val 
        355                 360                 365             


Glu Arg Leu Tyr Asn Gly Ile Glu Asn Gly Glu Glu Phe Lys Phe Glu 
    370                 375                 380                 


Thr Gly Tyr Ile Ser Glu Lys Val Trp Lys Ala Val Ile Asn His Leu 
385                 390                 395                 400 


Ser Ile Lys Tyr Ile Ala Leu Gly Lys Ala Val Tyr Asn Tyr Ala Met 
                405                 410                 415     


Lys Glu Leu Ser Ser Pro Gly Asp Ile Glu Pro Gly Lys Ile Asp Asp 
            420                 425                 430         


Ser Tyr Ile Asn Gly Ile Thr Ser Phe Asp Tyr Glu Ile Ile Lys Ala 
        435                 440                 445             


Glu Glu Ser Leu Gln Arg Asp Ile Ser Met Asn Val Val Phe Ala Thr 
    450                 455                 460                 


Asn Tyr Leu Ala Cys Ala Thr Val Asp Thr Asp Lys Asp Phe Leu Leu 
465                 470                 475                 480 


Phe Ser Lys Glu Asp Ile Arg Ser Cys Thr Lys Lys Asp Gly Asn Leu 
                485                 490                 495     


Cys Lys Asn Ile Met Gln Phe Trp Gly Gly Tyr Ser Thr Trp Lys Asn 
            500                 505                 510         


Phe Cys Glu Glu Tyr Leu Lys Asp Asp Lys Asp Ala Leu Glu Leu Leu 
        515                 520                 525             


Tyr Ser Leu Lys Ser Met Leu Tyr Ser Met Arg Asn Ser Ser Phe His 
    530                 535                 540                 


Phe Ser Thr Glu Asn Val Asp Asn Gly Ser Trp Asp Thr Glu Leu Ile 
545                 550                 555                 560 


Gly Lys Leu Phe Glu Glu Asp Cys Asn Arg Ala Ala Arg Ile Glu Lys 
                565                 570                 575     


Glu Lys Phe Tyr Asn Asn Asn Leu His Met Phe Tyr Ser Ser Ser Leu 
            580                 585                 590         


Leu Glu Lys Val Leu Glu Arg Leu Tyr Ser Ser His His Glu Arg Ala 
        595                 600                 605             


Ser Gln Val Pro Ser Phe Asn Arg Val Phe Val Arg Lys Asn Phe Pro 
    610                 615                 620                 


Ser Ser Leu Ser Glu Gln Arg Ile Thr Pro Lys Phe Thr Asp Ser Lys 
625                 630                 635                 640 


Asp Glu Gln Ile Trp Gln Ser Ala Val Tyr Tyr Leu Cys Lys Glu Ile 
                645                 650                 655     


Tyr Tyr Asn Asp Phe Leu Gln Ser Lys Glu Ala Tyr Lys Leu Phe Arg 
            660                 665                 670         


Glu Gly Val Lys Asn Leu Asp Lys Asn Asp Ile Asn Asn Gln Lys Ala 
        675                 680                 685             


Ala Asp Ser Phe Lys Gln Ala Val Val Tyr Tyr Gly Lys Ala Ile Gly 
    690                 695                 700                 


Asn Ala Thr Leu Ser Gln Val Cys Gln Ala Ile Met Thr Glu Tyr Asn 
705                 710                 715                 720 


Arg Gln Asn Asn Asp Gly Leu Lys Lys Lys Ser Ala Tyr Ala Glu Lys 
                725                 730                 735     


Gln Asn Ser Asn Lys Tyr Lys His Tyr Pro Leu Phe Leu Lys Gln Val 
            740                 745                 750         


Leu Gln Ser Ala Phe Trp Glu Tyr Leu Asp Glu Asn Lys Glu Ile Tyr 
        755                 760                 765             


Gly Phe Ile Ser Ala Gln Ile His Lys Ser Asn Val Glu Ile Lys Ala 
    770                 775                 780                 


Glu Asp Phe Ile Ala Asn Tyr Ser Ser Gln Gln Tyr Lys Lys Leu Val 
785                 790                 795                 800 


Asp Lys Val Lys Lys Thr Pro Glu Leu Gln Lys Trp Tyr Thr Leu Gly 
                805                 810                 815     


Arg Leu Ile Asn Pro Arg Gln Ala Asn Gln Phe Leu Gly Ser Ile Arg 
            820                 825                 830         


Asn Tyr Val Gln Phe Val Lys Asp Ile Gln Arg Arg Ala Lys Glu Asn 
        835                 840                 845             


Gly Asn Pro Ile Arg Asn Tyr Tyr Glu Val Leu Glu Ser Asp Ser Ile 
    850                 855                 860                 


Ile Lys Ile Leu Glu Met Cys Thr Lys Leu Asn Gly Thr Thr Ser Asn 
865                 870                 875                 880 


Asp Ile His Asp Tyr Phe Arg Asp Glu Asp Glu Tyr Ala Glu Tyr Ile 
                885                 890                 895     


Ser Gln Phe Val Asn Phe Gly Asp Val His Ser Gly Ala Ala Leu Asn 
            900                 905                 910         


Ala Phe Cys Asn Ser Glu Ser Glu Gly Lys Lys Asn Gly Ile Tyr Tyr 
        915                 920                 925             


Asp Gly Ile Asn Pro Ile Val Asn Arg Asn Trp Val Leu Cys Lys Leu 
    930                 935                 940                 


Tyr Gly Ser Pro Asp Leu Ile Ser Lys Ile Ile Ser Arg Val Asn Glu 
945                 950                 955                 960 


Asn Met Ile His Asp Phe His Lys Gln Glu Asp Leu Ile Arg Glu Tyr 
                965                 970                 975     


Gln Ile Lys Gly Ile Cys Ser Asn Lys Lys Glu Gln Gln Asp Leu Arg 
            980                 985                 990         


Thr Phe Gln Val Leu Lys Asn Arg  Val Glu Leu Arg Asp  Ile Val Glu 
        995                 1000                 1005             


Tyr Ser  Glu Ile Ile Asn Glu  Leu Tyr Gly Gln Leu  Ile Lys Trp 
    1010                 1015                 1020             


Cys Tyr  Leu Arg Glu Arg Asp  Leu Met Tyr Phe Gln  Leu Gly Phe 
    1025                 1030                 1035             


His Tyr  Leu Cys Leu Asn Asn  Ala Ser Ser Lys Glu  Ala Asp Tyr 
    1040                 1045                 1050             


Ile Lys  Ile Asn Val Asp Asp  Arg Asn Ile Ser Gly  Ala Ile Leu 
    1055                 1060                 1065             


Tyr Gln  Ile Ala Ala Met Tyr  Ile Asn Gly Leu Pro  Val Tyr Tyr 
    1070                 1075                 1080             


Lys Lys  Asp Asp Met Tyr Val  Ala Leu Lys Ser Gly  Lys Lys Ala 
    1085                 1090                 1095             


Ser Asp  Glu Leu Asn Ser Asn  Glu Gln Thr Ser Lys  Lys Ile Asn 
    1100                 1105                 1110             


Tyr Phe  Leu Lys Tyr Gly Asn  Asn Ile Leu Gly Asp  Lys Lys Asp 
    1115                 1120                 1125             


Gln Leu  Tyr Leu Ala Gly Leu  Glu Leu Phe Glu Asn  Val Ala Glu 
    1130                 1135                 1140             


His Glu  Asn Ile Ile Ile Phe  Arg Asn Glu Ile Asp  His Phe His 
    1145                 1150                 1155             


Tyr Phe  Tyr Asp Arg Asp Arg  Ser Met Leu Asp Leu  Tyr Ser Glu 
    1160                 1165                 1170             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Leu  Arg Lys Asn 
    1175                 1180                 1185             


Val Val  Asn Met Leu Tyr Asn  Ile Leu Leu Asp His  Asn Ile Val 
    1190                 1195                 1200             


Ser Ser  Phe Val Phe Glu Thr  Gly Glu Lys Lys Val  Gly Arg Gly 
    1205                 1210                 1215             


Asp Ser  Glu Val Ile Lys Pro  Ser Ala Lys Ile Arg  Leu Arg Ala 
    1220                 1225                 1230             


Asn Asn  Gly Val Ser Ser Asp  Val Phe Thr Tyr Lys  Val Gly Ser 
    1235                 1240                 1245             


Lys Asp  Glu Leu Lys Ile Ala  Thr Leu Pro Ala Lys  Asn Glu Glu 
    1250                 1255                 1260             


Phe Leu  Leu Asn Val Ala Arg  Leu Ile Tyr Tyr Pro  Asp Met Glu 
    1265                 1270                 1275             


Ala Val  Ser Glu Asn Met Val  Arg Glu Gly Val Val  Lys Val Glu 
    1280                 1285                 1290             


Lys Ser  Asn Asp Lys Lys Gly  Lys Ile Ser Arg Gly  Ser Asn Thr 
    1295                 1300                 1305             


Arg Ser  Ser Asn Gln Ser Lys  Tyr Asn Asn Lys Ser  Lys Asn Arg 
    1310                 1315                 1320             


Met Asn  Tyr Ser Met Gly Ser  Ile Phe Glu Lys Met  Asp Leu Lys 
    1325                 1330                 1335             


Phe Asp  
    1340 


<210>  25
<211>  1437
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  25

Met Lys Ile Ser Lys Val Arg Glu Glu Asn Arg Gly Ala Lys Leu Thr 
1               5                   10                  15      


Val Asn Ala Lys Thr Ala Val Val Ser Glu Asn Arg Ser Gln Glu Gly 
            20                  25                  30          


Ile Leu Tyr Asn Asp Pro Ser Arg Tyr Gly Lys Ser Arg Lys Asn Asp 
        35                  40                  45              


Glu Asp Arg Asp Arg Tyr Ile Glu Ser Arg Leu Lys Ser Ser Gly Lys 
    50                  55                  60                  


Leu Tyr Arg Ile Phe Asn Glu Asp Lys Asn Lys Arg Glu Thr Asp Glu 
65                  70                  75                  80  


Leu Gln Trp Phe Leu Ser Glu Ile Val Lys Lys Ile Asn Arg Arg Asn 
                85                  90                  95      


Gly Leu Val Leu Ser Asp Met Leu Ser Val Asp Asp Arg Ala Phe Glu 
            100                 105                 110         


Lys Ala Phe Glu Lys Tyr Ala Glu Leu Ser Tyr Thr Asn Arg Arg Asn 
        115                 120                 125             


Lys Val Ser Gly Ser Pro Ala Phe Glu Thr Cys Gly Val Asp Ala Ala 
    130                 135                 140                 


Thr Ala Glu Arg Leu Lys Gly Ile Ile Ser Glu Thr Asn Phe Ile Asn 
145                 150                 155                 160 


Arg Ile Lys Asn Asn Ile Asp Asn Lys Val Ser Glu Asp Ile Ile Asp 
                165                 170                 175     


Arg Ile Ile Ala Lys Tyr Leu Lys Lys Ser Leu Cys Arg Glu Arg Val 
            180                 185                 190         


Lys Arg Gly Leu Lys Lys Leu Leu Met Asn Ala Phe Asp Leu Pro Tyr 
        195                 200                 205             


Ser Asp Pro Asp Ile Asp Val Gln Arg Asp Phe Ile Asp Tyr Val Leu 
    210                 215                 220                 


Glu Asp Phe Tyr His Val Arg Ala Lys Ser Gln Val Ser Arg Ser Ile 
225                 230                 235                 240 


Lys Asn Met Asn Met Pro Val Gln Pro Glu Gly Asp Gly Lys Phe Ala 
                245                 250                 255     


Ile Thr Val Ser Lys Gly Gly Thr Glu Ser Gly Asn Lys Arg Ser Ala 
            260                 265                 270         


Glu Lys Glu Ala Phe Lys Lys Phe Leu Ser Asp Tyr Ala Ser Leu Asp 
        275                 280                 285             


Glu Arg Val Arg Asp Asp Met Leu Arg Arg Met Arg Arg Leu Val Val 
    290                 295                 300                 


Leu Tyr Phe Tyr Gly Ser Asp Asp Ser Lys Leu Ser Asp Val Asn Glu 
305                 310                 315                 320 


Lys Phe Asp Val Trp Glu Asp His Ala Ala Arg Arg Val Asp Asn Arg 
                325                 330                 335     


Glu Phe Ile Lys Leu Pro Leu Glu Asn Lys Leu Ala Asn Gly Lys Thr 
            340                 345                 350         


Asp Lys Asp Ala Glu Arg Ile Arg Lys Asn Thr Val Lys Glu Leu Tyr 
        355                 360                 365             


Arg Asn Gln Asn Ile Gly Cys Tyr Arg Gln Ala Val Lys Ala Val Glu 
    370                 375                 380                 


Glu Asp Asn Asn Gly Arg Tyr Phe Asp Asp Lys Met Leu Asn Met Phe 
385                 390                 395                 400 


Phe Ile His Arg Ile Glu Tyr Gly Val Glu Lys Ile Tyr Ala Asn Leu 
                405                 410                 415     


Lys Gln Val Thr Glu Phe Lys Ala Arg Thr Gly Tyr Leu Ser Glu Lys 
            420                 425                 430         


Ile Trp Lys Asp Leu Ile Asn Tyr Ile Ser Ile Lys Tyr Ile Ala Met 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Tyr Ala Met Asp Glu Leu Asn Ala Ser Asp 
    450                 455                 460                 


Lys Lys Glu Ile Glu Leu Gly Lys Ile Ser Glu Glu Tyr Leu Ser Gly 
465                 470                 475                 480 


Ile Ser Ser Phe Asp Tyr Glu Leu Ile Lys Ala Glu Glu Met Leu Gln 
                485                 490                 495     


Arg Glu Thr Ala Val Tyr Val Ala Phe Ala Ala Arg His Leu Ser Ser 
            500                 505                 510         


Gln Thr Val Glu Leu Asp Ser Glu Asn Ser Asp Phe Leu Leu Leu Lys 
        515                 520                 525             


Pro Lys Gly Thr Met Asp Lys Asn Asp Lys Asn Lys Leu Ala Ser Asn 
    530                 535                 540                 


Asn Ile Leu Asn Phe Leu Lys Asp Lys Glu Thr Leu Arg Asp Thr Ile 
545                 550                 555                 560 


Leu Gln Tyr Phe Gly Gly His Ser Leu Trp Thr Asp Phe Pro Phe Asp 
                565                 570                 575     


Lys Tyr Leu Ala Gly Gly Lys Asp Asp Val Asp Phe Leu Thr Asp Leu 
            580                 585                 590         


Lys Asp Val Ile Tyr Ser Met Arg Asn Asp Ser Phe His Tyr Ala Thr 
        595                 600                 605             


Glu Asn His Asn Asn Gly Lys Trp Asn Lys Glu Leu Ile Ser Ala Met 
    610                 615                 620                 


Phe Glu His Glu Thr Glu Arg Met Thr Val Val Met Lys Asp Lys Phe 
625                 630                 635                 640 


Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Asn Asp Asp Leu Lys Lys 
                645                 650                 655     


Leu Leu Ile Asp Leu Tyr Lys Asp Asn Val Glu Arg Ala Ser Gln Val 
            660                 665                 670         


Pro Ser Phe Asn Lys Val Phe Val Arg Lys Asn Phe Pro Ala Leu Val 
        675                 680                 685             


Arg Asp Lys Asp Asn Leu Gly Ile Glu Leu Asp Leu Lys Ala Asp Ala 
    690                 695                 700                 


Asp Lys Gly Glu Asn Glu Leu Lys Phe Tyr Asn Ala Leu Tyr Tyr Met 
705                 710                 715                 720 


Phe Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Asn Asp Lys Asn Val Arg 
                725                 730                 735     


Glu Arg Phe Ile Thr Lys Ala Thr Lys Val Ala Asp Asn Tyr Asp Arg 
            740                 745                 750         


Asn Lys Glu Arg Asn Leu Lys Asp Arg Ile Lys Ser Ala Gly Ser Asp 
        755                 760                 765             


Glu Lys Lys Lys Leu Arg Glu Gln Leu Gln Asn Tyr Ile Ala Glu Asn 
    770                 775                 780                 


Asp Phe Gly Gln Arg Ile Lys Asn Ile Val Gln Val Asn Pro Asp Tyr 
785                 790                 795                 800 


Thr Leu Ala Gln Ile Cys Gln Leu Ile Met Thr Glu Tyr Asn Gln Gln 
                805                 810                 815     


Asn Asn Gly Cys Met Gln Lys Lys Ser Ala Ala Arg Lys Asp Ile Asn 
            820                 825                 830         


Lys Asp Ser Tyr Gln His Tyr Lys Met Leu Leu Leu Val Asn Leu Arg 
        835                 840                 845             


Lys Ala Phe Leu Glu Phe Ile Lys Glu Asn Tyr Ala Phe Val Leu Lys 
    850                 855                 860                 


Pro Tyr Lys His Asp Leu Cys Asp Lys Ala Asp Phe Val Pro Asp Phe 
865                 870                 875                 880 


Ala Lys Tyr Val Lys Pro Tyr Ala Gly Leu Ile Ser Arg Val Ala Gly 
                885                 890                 895     


Ser Ser Glu Leu Gln Lys Trp Tyr Ile Val Ser Arg Phe Leu Ser Pro 
            900                 905                 910         


Ala Gln Ala Asn His Met Leu Gly Phe Leu His Ser Tyr Lys Gln Tyr 
        915                 920                 925             


Val Trp Asp Ile Tyr Arg Arg Ala Ser Glu Thr Gly Thr Glu Ile Asn 
    930                 935                 940                 


His Ser Ile Ala Glu Asp Lys Ile Ala Gly Val Asp Ile Thr Asp Val 
945                 950                 955                 960 


Asp Ala Val Ile Asp Leu Ser Val Lys Leu Cys Gly Thr Ile Ser Ser 
                965                 970                 975     


Glu Ile Ser Asp Tyr Phe Lys Asp Asp Glu Val Tyr Ala Glu Tyr Ile 
            980                 985                 990         


Ser Ser Tyr Leu Asp Phe Glu Tyr  Asp Gly Gly Asn Tyr  Lys Asp Ser 
        995                 1000                 1005             


Leu Asn  Arg Phe Cys Asn Ser  Asp Ala Val Asn Asp  Gln Lys Val 
    1010                 1015                 1020             


Ala Leu  Tyr Tyr Asp Gly Glu  His Pro Lys Leu Asn  Arg Asn Ile 
    1025                 1030                 1035             


Ile Leu  Ser Lys Leu Tyr Gly  Glu Arg Arg Phe Leu  Glu Lys Ile 
    1040                 1045                 1050             


Thr Asp  Arg Val Ser Arg Ser  Asp Ile Val Glu Tyr  Tyr Lys Leu 
    1055                 1060                 1065             


Lys Lys  Glu Thr Ser Gln Tyr  Gln Thr Lys Gly Ile  Phe Asp Ser 
    1070                 1075                 1080             


Glu Asp  Glu Gln Lys Asn Ile  Lys Lys Phe Gln Glu  Met Lys Asn 
    1085                 1090                 1095             


Ile Val  Glu Phe Arg Asp Leu  Met Asp Tyr Ser Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Leu  Gln Gly Gln Leu Ile  Asn Trp Ile Tyr Leu  Arg Glu Arg 
    1115                 1120                 1125             


Asp Leu  Met Asn Phe Gln Leu  Gly Tyr His Tyr Ala  Cys Leu Asn 
    1130                 1135                 1140             


Asn Asp  Ser Asn Lys Gln Ala  Thr Tyr Val Thr Leu  Asp Tyr Gln 
    1145                 1150                 1155             


Gly Lys  Lys Asn Arg Lys Ile  Asn Gly Ala Ile Leu  Tyr Gln Ile 
    1160                 1165                 1170             


Cys Ala  Met Tyr Ile Asn Gly  Leu Pro Leu Tyr Tyr  Val Asp Lys 
    1175                 1180                 1185             


Asp Ser  Ser Glu Trp Thr Val  Ser Asp Gly Lys Glu  Ser Thr Gly 
    1190                 1195                 1200             


Ala Lys  Ile Gly Glu Phe Tyr  Arg Tyr Ala Lys Ser  Phe Glu Asn 
    1205                 1210                 1215             


Thr Ser  Asp Cys Tyr Ala Ser  Gly Leu Glu Ile Phe  Glu Asn Ile 
    1220                 1225                 1230             


Ser Glu  His Asp Asn Ile Thr  Glu Leu Arg Asn Tyr  Ile Glu His 
    1235                 1240                 1245             


Phe Arg  Tyr Tyr Ser Ser Phe  Asp Arg Ser Phe Leu  Gly Ile Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Arg 
    1265                 1270                 1275             


Lys Asn  Val Pro Thr Ile Leu  Tyr Asn Ile Leu Leu  Gln His Phe 
    1280                 1285                 1290             


Val Asn  Val Arg Phe Glu Phe  Val Ser Gly Lys Lys  Met Ile Gly 
    1295                 1300                 1305             


Ile Asp  Lys Lys Asp Arg Lys  Ile Ala Lys Glu Lys  Glu Cys Ala 
    1310                 1315                 1320             


Arg Ile  Thr Ile Arg Glu Lys  Asn Gly Val Tyr Ser  Glu Gln Phe 
    1325                 1330                 1335             


Thr Tyr  Lys Leu Lys Asn Gly  Thr Val Tyr Val Asp  Ala Arg Asp 
    1340                 1345                 1350             


Lys Arg  Tyr Leu Gln Ser Ile  Ile Arg Leu Leu Phe  Tyr Pro Glu 
    1355                 1360                 1365             


Lys Val  Asn Met Asp Glu Met  Ile Glu Val Lys Glu  Lys Lys Lys 
    1370                 1375                 1380             


Pro Ser  Asp Asn Asn Thr Gly  Lys Gly Tyr Ser Lys  Arg Asp Arg 
    1385                 1390                 1395             


Gln Gln  Asp Arg Lys Glu Tyr  Asp Lys Tyr Lys Glu  Lys Lys Lys 
    1400                 1405                 1410             


Lys Glu  Gly Asn Phe Leu Ser  Gly Met Gly Gly Asn  Ile Asn Trp 
    1415                 1420                 1425             


Asp Glu  Ile Asn Ala Gln Leu  Lys Asn 
    1430                 1435         


<210>  26
<211>  1385
<212>  PRT
<213>  Clostridium aminophilum

<400>  26

Met Lys Phe Ser Lys Val Asp His Thr Arg Ser Ala Val Gly Ile Gln 
1               5                   10                  15      


Lys Ala Thr Asp Ser Val His Gly Met Leu Tyr Thr Asp Pro Lys Lys 
            20                  25                  30          


Gln Glu Val Asn Asp Leu Asp Lys Arg Phe Asp Gln Leu Asn Val Lys 
        35                  40                  45              


Ala Lys Arg Leu Tyr Asn Val Phe Asn Gln Ser Lys Ala Glu Glu Asp 
    50                  55                  60                  


Asp Asp Glu Lys Arg Phe Gly Lys Val Val Lys Lys Leu Asn Arg Glu 
65                  70                  75                  80  


Leu Lys Asp Leu Leu Phe His Arg Glu Val Ser Arg Tyr Asn Ser Ile 
                85                  90                  95      


Gly Asn Ala Lys Tyr Asn Tyr Tyr Gly Ile Lys Ser Asn Pro Glu Glu 
            100                 105                 110         


Ile Val Ser Asn Leu Gly Met Val Glu Ser Leu Lys Gly Glu Arg Asp 
        115                 120                 125             


Pro Gln Lys Val Ile Ser Lys Leu Leu Leu Tyr Tyr Leu Arg Lys Gly 
    130                 135                 140                 


Leu Lys Pro Gly Thr Asp Gly Leu Arg Met Ile Leu Glu Ala Ser Cys 
145                 150                 155                 160 


Gly Leu Arg Lys Leu Ser Gly Asp Glu Lys Glu Leu Lys Val Phe Leu 
                165                 170                 175     


Gln Thr Leu Asp Glu Asp Phe Glu Lys Lys Thr Phe Lys Lys Asn Leu 
            180                 185                 190         


Ile Arg Ser Ile Glu Asn Gln Asn Met Ala Val Gln Pro Ser Asn Glu 
        195                 200                 205             


Gly Asp Pro Ile Ile Gly Ile Thr Gln Gly Arg Phe Asn Ser Gln Lys 
    210                 215                 220                 


Asn Glu Glu Lys Ser Ala Ile Glu Arg Met Met Ser Met Tyr Ala Asp 
225                 230                 235                 240 


Leu Asn Glu Asp His Arg Glu Asp Val Leu Arg Lys Leu Arg Arg Leu 
                245                 250                 255     


Asn Val Leu Tyr Phe Asn Val Asp Thr Glu Lys Thr Glu Glu Pro Thr 
            260                 265                 270         


Leu Pro Gly Glu Val Asp Thr Asn Pro Val Phe Glu Val Trp His Asp 
        275                 280                 285             


His Glu Lys Gly Lys Glu Asn Asp Arg Gln Phe Ala Thr Phe Ala Lys 
    290                 295                 300                 


Ile Leu Thr Glu Asp Arg Glu Thr Arg Lys Lys Glu Lys Leu Ala Val 
305                 310                 315                 320 


Lys Glu Ala Leu Asn Asp Leu Lys Ser Ala Ile Arg Asp His Asn Ile 
                325                 330                 335     


Met Ala Tyr Arg Cys Ser Ile Lys Val Thr Glu Gln Asp Lys Asp Gly 
            340                 345                 350         


Leu Phe Phe Glu Asp Gln Arg Ile Asn Arg Phe Trp Ile His His Ile 
        355                 360                 365             


Glu Ser Ala Val Glu Arg Ile Leu Ala Ser Ile Asn Pro Glu Lys Leu 
    370                 375                 380                 


Tyr Lys Leu Arg Ile Gly Tyr Leu Gly Glu Lys Val Trp Lys Asp Leu 
385                 390                 395                 400 


Leu Asn Tyr Leu Ser Ile Lys Tyr Ile Ala Val Gly Lys Ala Val Phe 
                405                 410                 415     


His Phe Ala Met Glu Asp Leu Gly Lys Thr Gly Gln Asp Ile Glu Leu 
            420                 425                 430         


Gly Lys Leu Ser Asn Ser Val Ser Gly Gly Leu Thr Ser Phe Asp Tyr 
        435                 440                 445             


Glu Gln Ile Arg Ala Asp Glu Thr Leu Gln Arg Gln Leu Ser Val Glu 
    450                 455                 460                 


Val Ala Phe Ala Ala Asn Asn Leu Phe Arg Ala Val Val Gly Gln Thr 
465                 470                 475                 480 


Gly Lys Lys Ile Glu Gln Ser Lys Ser Glu Glu Asn Glu Glu Asp Phe 
                485                 490                 495     


Leu Leu Trp Lys Ala Glu Lys Ile Ala Glu Ser Ile Lys Lys Glu Gly 
            500                 505                 510         


Glu Gly Asn Thr Leu Lys Ser Ile Leu Gln Phe Phe Gly Gly Ala Ser 
        515                 520                 525             


Ser Trp Asp Leu Asn His Phe Cys Ala Ala Tyr Gly Asn Glu Ser Ser 
    530                 535                 540                 


Ala Leu Gly Tyr Glu Thr Lys Phe Ala Asp Asp Leu Arg Lys Ala Ile 
545                 550                 555                 560 


Tyr Ser Leu Arg Asn Glu Thr Phe His Phe Thr Thr Leu Asn Lys Gly 
                565                 570                 575     


Ser Phe Asp Trp Asn Ala Lys Leu Ile Gly Asp Met Phe Ser His Glu 
            580                 585                 590         


Ala Ala Thr Gly Ile Ala Val Glu Arg Thr Arg Phe Tyr Ser Asn Asn 
        595                 600                 605             


Leu Pro Met Phe Tyr Arg Glu Ser Asp Leu Lys Arg Ile Met Asp His 
    610                 615                 620                 


Leu Tyr Asn Thr Tyr His Pro Arg Ala Ser Gln Val Pro Ser Phe Asn 
625                 630                 635                 640 


Ser Val Phe Val Arg Lys Asn Phe Arg Leu Phe Leu Ser Asn Thr Leu 
                645                 650                 655     


Asn Thr Asn Thr Ser Phe Asp Thr Glu Val Tyr Gln Lys Trp Glu Ser 
            660                 665                 670         


Gly Val Tyr Tyr Leu Phe Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Pro 
        675                 680                 685             


Ser Gly Asp Ala His His Leu Phe Phe Glu Gly Leu Arg Arg Ile Arg 
    690                 695                 700                 


Lys Glu Ala Asp Asn Leu Pro Ile Val Gly Lys Glu Ala Lys Lys Arg 
705                 710                 715                 720 


Asn Ala Val Gln Asp Phe Gly Arg Arg Cys Asp Glu Leu Lys Asn Leu 
                725                 730                 735     


Ser Leu Ser Ala Ile Cys Gln Met Ile Met Thr Glu Tyr Asn Glu Gln 
            740                 745                 750         


Asn Asn Gly Asn Arg Lys Val Lys Ser Thr Arg Glu Asp Lys Arg Lys 
        755                 760                 765             


Pro Asp Ile Phe Gln His Tyr Lys Met Leu Leu Leu Arg Thr Leu Gln 
    770                 775                 780                 


Glu Ala Phe Ala Ile Tyr Ile Arg Arg Glu Glu Phe Lys Phe Ile Phe 
785                 790                 795                 800 


Asp Leu Pro Lys Thr Leu Tyr Val Met Lys Pro Val Glu Glu Phe Leu 
                805                 810                 815     


Pro Asn Trp Lys Ser Gly Met Phe Asp Ser Leu Val Glu Arg Val Lys 
            820                 825                 830         


Gln Ser Pro Asp Leu Gln Arg Trp Tyr Val Leu Cys Lys Phe Leu Asn 
        835                 840                 845             


Gly Arg Leu Leu Asn Gln Leu Ser Gly Val Ile Arg Ser Tyr Ile Gln 
    850                 855                 860                 


Phe Ala Gly Asp Ile Gln Arg Arg Ala Lys Ala Asn His Asn Arg Leu 
865                 870                 875                 880 


Tyr Met Asp Asn Thr Gln Arg Val Glu Tyr Tyr Ser Asn Val Leu Glu 
                885                 890                 895     


Val Val Asp Phe Cys Ile Lys Gly Thr Ser Arg Phe Ser Asn Val Phe 
            900                 905                 910         


Ser Asp Tyr Phe Arg Asp Glu Asp Ala Tyr Ala Asp Tyr Leu Asp Asn 
        915                 920                 925             


Tyr Leu Gln Phe Lys Asp Glu Lys Ile Ala Glu Val Ser Ser Phe Ala 
    930                 935                 940                 


Ala Leu Lys Thr Phe Cys Asn Glu Glu Glu Val Lys Ala Gly Ile Tyr 
945                 950                 955                 960 


Met Asp Gly Glu Asn Pro Val Met Gln Arg Asn Ile Val Met Ala Lys 
                965                 970                 975     


Leu Phe Gly Pro Asp Glu Val Leu Lys Asn Val Val Pro Lys Val Thr 
            980                 985                 990         


Arg Glu Glu Ile Glu Glu Tyr Tyr  Gln Leu Glu Lys Gln  Ile Ala Pro 
        995                 1000                 1005             


Tyr Arg  Gln Asn Gly Tyr Cys  Lys Ser Glu Glu Asp  Gln Lys Lys 
    1010                 1015                 1020             


Leu Leu  Arg Phe Gln Arg Ile  Lys Asn Arg Val Glu  Phe Gln Thr 
    1025                 1030                 1035             


Ile Thr  Glu Phe Ser Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu 
    1040                 1045                 1050             


Ile Ser  Trp Ser Phe Leu Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln 
    1055                 1060                 1065             


Leu Gly  Phe His Tyr Leu Cys  Leu His Asn Asp Thr  Glu Lys Pro 
    1070                 1075                 1080             


Ala Glu  Tyr Lys Glu Ile Ser  Arg Glu Asp Gly Thr  Val Ile Arg 
    1085                 1090                 1095             


Asn Ala  Ile Leu His Gln Val  Ala Ala Met Tyr Val  Gly Gly Leu 
    1100                 1105                 1110             


Pro Val  Tyr Thr Leu Ala Asp  Lys Lys Leu Ala Ala  Phe Glu Lys 
    1115                 1120                 1125             


Gly Glu  Ala Asp Cys Lys Leu  Ser Ile Ser Lys Asp  Thr Ala Gly 
    1130                 1135                 1140             


Ala Gly  Lys Lys Ile Lys Asp  Phe Phe Arg Tyr Ser  Lys Tyr Val 
    1145                 1150                 1155             


Leu Ile  Lys Asp Arg Met Leu  Thr Asp Gln Asn Gln  Lys Tyr Thr 
    1160                 1165                 1170             


Ile Tyr  Leu Ala Gly Leu Glu  Leu Phe Glu Asn Thr  Asp Glu His 
    1175                 1180                 1185             


Asp Asn  Ile Thr Asp Val Arg  Lys Tyr Val Asp His  Phe Lys Tyr 
    1190                 1195                 1200             


Tyr Ala  Thr Ser Asp Glu Asn  Ala Met Ser Ile Leu  Asp Leu Tyr 
    1205                 1210                 1215             


Ser Glu  Ile His Asp Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Gln 
    1220                 1225                 1230             


Lys Asn  Val Ala Asn Met Leu  Glu Asn Ile Leu Leu  Arg His Phe 
    1235                 1240                 1245             


Val Leu  Ile Arg Pro Glu Phe  Phe Thr Gly Ser Lys  Lys Val Gly 
    1250                 1255                 1260             


Glu Gly  Lys Lys Ile Thr Cys  Lys Ala Arg Ala Gln  Ile Glu Ile 
    1265                 1270                 1275             


Ala Glu  Asn Gly Met Arg Ser  Glu Asp Phe Thr Tyr  Lys Leu Ser 
    1280                 1285                 1290             


Asp Gly  Lys Lys Asn Ile Ser  Thr Cys Met Ile Ala  Ala Arg Asp 
    1295                 1300                 1305             


Gln Lys  Tyr Leu Asn Thr Val  Ala Arg Leu Leu Tyr  Tyr Pro His 
    1310                 1315                 1320             


Glu Ala  Lys Lys Ser Ile Val  Asp Thr Arg Glu Lys  Lys Asn Asn 
    1325                 1330                 1335             


Lys Lys  Thr Asn Arg Gly Asp  Gly Thr Phe Asn Lys  Gln Lys Gly 
    1340                 1345                 1350             


Thr Ala  Arg Lys Glu Lys Asp  Asn Gly Pro Arg Glu  Phe Asn Asp 
    1355                 1360                 1365             


Thr Gly  Phe Ser Asn Thr Pro  Phe Ala Gly Phe Asp  Pro Phe Arg 
    1370                 1375                 1380             


Asn Ser  
    1385 


<210>  27
<211>  1175
<212>  PRT
<213>  Carnobacterium gallinarum

<400>  27

Met Arg Ile Thr Lys Val Lys Ile Lys Leu Asp Asn Lys Leu Tyr Gln 
1               5                   10                  15      


Val Thr Met Gln Lys Glu Glu Lys Tyr Gly Thr Leu Lys Leu Asn Glu 
            20                  25                  30          


Glu Ser Arg Lys Ser Thr Ala Glu Ile Leu Arg Leu Lys Lys Ala Ser 
        35                  40                  45              


Phe Asn Lys Ser Phe His Ser Lys Thr Ile Asn Ser Gln Lys Glu Asn 
    50                  55                  60                  


Lys Asn Ala Thr Ile Lys Lys Asn Gly Asp Tyr Ile Ser Gln Ile Phe 
65                  70                  75                  80  


Glu Lys Leu Val Gly Val Asp Thr Asn Lys Asn Ile Arg Lys Pro Lys 
                85                  90                  95      


Met Ser Leu Thr Asp Leu Lys Asp Leu Pro Lys Lys Asp Leu Ala Leu 
            100                 105                 110         


Phe Ile Lys Arg Lys Phe Lys Asn Asp Asp Ile Val Glu Ile Lys Asn 
        115                 120                 125             


Leu Asp Leu Ile Ser Leu Phe Tyr Asn Ala Leu Gln Lys Val Pro Gly 
    130                 135                 140                 


Glu His Phe Thr Asp Glu Ser Trp Ala Asp Phe Cys Gln Glu Met Met 
145                 150                 155                 160 


Pro Tyr Arg Glu Tyr Lys Asn Lys Phe Ile Glu Arg Lys Ile Ile Leu 
                165                 170                 175     


Leu Ala Asn Ser Ile Glu Gln Asn Lys Gly Phe Ser Ile Asn Pro Glu 
            180                 185                 190         


Thr Phe Ser Lys Arg Lys Arg Val Leu His Gln Trp Ala Ile Glu Val 
        195                 200                 205             


Gln Glu Arg Gly Asp Phe Ser Ile Leu Asp Glu Lys Leu Ser Lys Leu 
    210                 215                 220                 


Ala Glu Ile Tyr Asn Phe Lys Lys Met Cys Lys Arg Val Gln Asp Glu 
225                 230                 235                 240 


Leu Asn Asp Leu Glu Lys Ser Met Lys Lys Gly Lys Asn Pro Glu Lys 
                245                 250                 255     


Glu Lys Glu Ala Tyr Lys Lys Gln Lys Asn Phe Lys Ile Lys Thr Ile 
            260                 265                 270         


Trp Lys Asp Tyr Pro Tyr Lys Thr His Ile Gly Leu Ile Glu Lys Ile 
        275                 280                 285             


Lys Glu Asn Glu Glu Leu Asn Gln Phe Asn Ile Glu Ile Gly Lys Tyr 
    290                 295                 300                 


Phe Glu His Tyr Phe Pro Ile Lys Lys Glu Arg Cys Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Tyr Tyr Leu Asn Ser Glu Thr Ile Ala Thr Thr Val Asn Tyr Gln 
                325                 330                 335     


Leu Lys Asn Ala Leu Ile Ser Tyr Leu Met Gln Ile Gly Lys Tyr Lys 
            340                 345                 350         


Gln Phe Gly Leu Glu Asn Gln Val Leu Asp Ser Lys Lys Leu Gln Glu 
        355                 360                 365             


Ile Gly Ile Tyr Glu Gly Phe Gln Thr Lys Phe Met Asp Ala Cys Val 
    370                 375                 380                 


Phe Ala Thr Ser Ser Leu Lys Asn Ile Ile Glu Pro Met Arg Ser Gly 
385                 390                 395                 400 


Asp Ile Leu Gly Lys Arg Glu Phe Lys Glu Ala Ile Ala Thr Ser Ser 
                405                 410                 415     


Phe Val Asn Tyr His His Phe Phe Pro Tyr Phe Pro Phe Glu Leu Lys 
            420                 425                 430         


Gly Met Lys Asp Arg Glu Ser Glu Leu Ile Pro Phe Gly Glu Gln Thr 
        435                 440                 445             


Glu Ala Lys Gln Met Gln Asn Ile Trp Ala Leu Arg Gly Ser Val Gln 
    450                 455                 460                 


Gln Ile Arg Asn Glu Ile Phe His Ser Phe Asp Lys Asn Gln Lys Phe 
465                 470                 475                 480 


Asn Leu Pro Gln Leu Asp Lys Ser Asn Phe Glu Phe Asp Ala Ser Glu 
                485                 490                 495     


Asn Ser Thr Gly Lys Ser Gln Ser Tyr Ile Glu Thr Asp Tyr Lys Phe 
            500                 505                 510         


Leu Phe Glu Ala Glu Lys Asn Gln Leu Glu Gln Phe Phe Ile Glu Arg 
        515                 520                 525             


Ile Lys Ser Ser Gly Ala Leu Glu Tyr Tyr Pro Leu Lys Ser Leu Glu 
    530                 535                 540                 


Lys Leu Phe Ala Lys Lys Glu Met Lys Phe Ser Leu Gly Ser Gln Val 
545                 550                 555                 560 


Val Ala Phe Ala Pro Ser Tyr Lys Lys Leu Val Lys Lys Gly His Ser 
                565                 570                 575     


Tyr Gln Thr Ala Thr Glu Gly Thr Ala Asn Tyr Leu Gly Leu Ser Tyr 
            580                 585                 590         


Tyr Asn Arg Tyr Glu Leu Lys Glu Glu Ser Phe Gln Ala Gln Tyr Tyr 
        595                 600                 605             


Leu Leu Lys Leu Ile Tyr Gln Tyr Val Phe Leu Pro Asn Phe Ser Gln 
    610                 615                 620                 


Gly Asn Ser Pro Ala Phe Arg Glu Thr Val Lys Ala Ile Leu Arg Ile 
625                 630                 635                 640 


Asn Lys Asp Glu Ala Arg Lys Lys Met Lys Lys Asn Lys Lys Phe Leu 
                645                 650                 655     


Arg Lys Tyr Ala Phe Glu Gln Val Arg Glu Met Glu Phe Lys Glu Thr 
            660                 665                 670         


Pro Asp Gln Tyr Met Ser Tyr Leu Gln Ser Glu Met Arg Glu Glu Lys 
        675                 680                 685             


Val Arg Lys Ala Glu Lys Asn Asp Lys Gly Phe Glu Lys Asn Ile Thr 
    690                 695                 700                 


Met Asn Phe Glu Lys Leu Leu Met Gln Ile Phe Val Lys Gly Phe Asp 
705                 710                 715                 720 


Val Phe Leu Thr Thr Phe Ala Gly Lys Glu Leu Leu Leu Ser Ser Glu 
                725                 730                 735     


Glu Lys Val Ile Lys Glu Thr Glu Ile Ser Leu Ser Lys Lys Ile Asn 
            740                 745                 750         


Glu Arg Glu Lys Thr Leu Lys Ala Ser Ile Gln Val Glu His Gln Leu 
        755                 760                 765             


Val Ala Thr Asn Ser Ala Ile Ser Tyr Trp Leu Phe Cys Lys Leu Leu 
    770                 775                 780                 


Asp Ser Arg His Leu Asn Glu Leu Arg Asn Glu Met Ile Lys Phe Lys 
785                 790                 795                 800 


Gln Ser Arg Ile Lys Phe Asn His Thr Gln His Ala Glu Leu Ile Gln 
                805                 810                 815     


Asn Leu Leu Pro Ile Val Glu Leu Thr Ile Leu Ser Asn Asp Tyr Asp 
            820                 825                 830         


Glu Lys Asn Asp Ser Gln Asn Val Asp Val Ser Ala Tyr Phe Glu Asp 
        835                 840                 845             


Lys Ser Leu Tyr Glu Thr Ala Pro Tyr Val Gln Thr Asp Asp Arg Thr 
    850                 855                 860                 


Arg Val Ser Phe Arg Pro Ile Leu Lys Leu Glu Lys Tyr His Thr Lys 
865                 870                 875                 880 


Ser Leu Ile Glu Ala Leu Leu Lys Asp Asn Pro Gln Phe Arg Val Ala 
                885                 890                 895     


Ala Thr Asp Ile Gln Glu Trp Met His Lys Arg Glu Glu Ile Gly Glu 
            900                 905                 910         


Leu Val Glu Lys Arg Lys Asn Leu His Thr Glu Trp Ala Glu Gly Gln 
        915                 920                 925             


Gln Thr Leu Gly Ala Glu Lys Arg Glu Glu Tyr Arg Asp Tyr Cys Lys 
    930                 935                 940                 


Lys Ile Asp Arg Phe Asn Trp Lys Ala Asn Lys Val Thr Leu Thr Tyr 
945                 950                 955                 960 


Leu Ser Gln Leu His Tyr Leu Ile Thr Asp Leu Leu Gly Arg Met Val 
                965                 970                 975     


Gly Phe Ser Ala Leu Phe Glu Arg Asp Leu Val Tyr Phe Ser Arg Ser 
            980                 985                 990         


Phe Ser Glu Leu Gly Gly Glu Thr  Tyr His Ile Ser Asp  Tyr Lys Asn 
        995                 1000                 1005             


Leu Ser  Gly Val Leu Arg Leu  Asn Ala Glu Val Lys  Pro Ile Lys 
    1010                 1015                 1020             


Ile Lys  Asn Ile Lys Val Ile  Asp Asn Glu Glu Asn  Pro Tyr Lys 
    1025                 1030                 1035             


Gly Asn  Glu Pro Glu Val Lys  Pro Phe Leu Asp Arg  Leu His Ala 
    1040                 1045                 1050             


Tyr Leu  Glu Asn Val Ile Gly  Ile Lys Ala Val His  Gly Lys Ile 
    1055                 1060                 1065             


Arg Asn  Gln Thr Ala His Leu  Ser Val Leu Gln Leu  Glu Leu Ser 
    1070                 1075                 1080             


Met Ile  Glu Ser Met Asn Asn  Leu Arg Asp Leu Met  Ala Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Thr Lys Ser Met Ile  Lys Ile Leu 
    1100                 1105                 1110             


Asp Lys  His Gly Met Ile Leu  Lys Leu Lys Ile Asp  Glu Asn His 
    1115                 1120                 1125             


Lys Asn  Phe Glu Ile Glu Ser  Leu Ile Pro Lys Glu  Ile Ile His 
    1130                 1135                 1140             


Leu Lys  Asp Lys Ala Ile Lys  Thr Asn Gln Val Ser  Glu Glu Tyr 
    1145                 1150                 1155             


Cys Gln  Leu Val Leu Ala Leu  Leu Thr Thr Asn Pro  Gly Asn Gln 
    1160                 1165                 1170             


Leu Asn  
    1175 


<210>  28
<211>  1164
<212>  PRT
<213>  Carnobacterium gallinarum

<400>  28

Met Arg Met Thr Lys Val Lys Ile Asn Gly Ser Pro Val Ser Met Asn 
1               5                   10                  15      


Arg Ser Lys Leu Asn Gly His Leu Val Trp Asn Gly Thr Thr Asn Thr 
            20                  25                  30          


Val Asn Ile Leu Thr Lys Lys Glu Gln Ser Phe Ala Ala Ser Phe Leu 
        35                  40                  45              


Asn Lys Thr Leu Val Lys Ala Asp Gln Val Lys Gly Tyr Lys Val Leu 
    50                  55                  60                  


Ala Glu Asn Ile Phe Ile Ile Phe Glu Gln Leu Glu Lys Ser Asn Ser 
65                  70                  75                  80  


Glu Lys Pro Ser Val Tyr Leu Asn Asn Ile Arg Arg Leu Lys Glu Ala 
                85                  90                  95      


Gly Leu Lys Arg Phe Phe Lys Ser Lys Tyr His Glu Glu Ile Lys Tyr 
            100                 105                 110         


Thr Ser Glu Lys Asn Gln Ser Val Pro Thr Lys Leu Asn Leu Ile Pro 
        115                 120                 125             


Leu Phe Phe Asn Ala Val Asp Arg Ile Gln Glu Asp Lys Phe Asp Glu 
    130                 135                 140                 


Lys Asn Trp Ser Tyr Phe Cys Lys Glu Met Ser Pro Tyr Leu Asp Tyr 
145                 150                 155                 160 


Lys Lys Ser Tyr Leu Asn Arg Lys Lys Glu Ile Leu Ala Asn Ser Ile 
                165                 170                 175     


Gln Gln Asn Arg Gly Phe Ser Met Pro Thr Ala Glu Glu Pro Asn Leu 
            180                 185                 190         


Leu Ser Lys Arg Lys Gln Leu Phe Gln Gln Trp Ala Met Lys Phe Gln 
        195                 200                 205             


Glu Ser Pro Leu Ile Gln Gln Asn Asn Phe Ala Val Glu Gln Phe Asn 
    210                 215                 220                 


Lys Glu Phe Ala Asn Lys Ile Asn Glu Leu Ala Ala Val Tyr Asn Val 
225                 230                 235                 240 


Asp Glu Leu Cys Thr Ala Ile Thr Glu Lys Leu Met Asn Phe Asp Lys 
                245                 250                 255     


Asp Lys Ser Asn Lys Thr Arg Asn Phe Glu Ile Lys Lys Leu Trp Lys 
            260                 265                 270         


Gln His Pro His Asn Lys Asp Lys Ala Leu Ile Lys Leu Phe Asn Gln 
        275                 280                 285             


Glu Gly Asn Glu Ala Leu Asn Gln Phe Asn Ile Glu Leu Gly Lys Tyr 
    290                 295                 300                 


Phe Glu His Tyr Phe Pro Lys Thr Gly Lys Lys Glu Ser Ala Glu Ser 
305                 310                 315                 320 


Tyr Tyr Leu Asn Pro Gln Thr Ile Ile Lys Thr Val Gly Tyr Gln Leu 
                325                 330                 335     


Arg Asn Ala Phe Val Gln Tyr Leu Leu Gln Val Gly Lys Leu His Gln 
            340                 345                 350         


Tyr Asn Lys Gly Val Leu Asp Ser Gln Thr Leu Gln Glu Ile Gly Met 
        355                 360                 365             


Tyr Glu Gly Phe Gln Thr Lys Phe Met Asp Ala Cys Val Phe Ala Ser 
    370                 375                 380                 


Ser Ser Leu Arg Asn Ile Ile Gln Ala Thr Thr Asn Glu Asp Ile Leu 
385                 390                 395                 400 


Thr Arg Glu Lys Phe Lys Lys Glu Leu Glu Lys Asn Val Glu Leu Lys 
                405                 410                 415     


His Asp Leu Phe Phe Lys Thr Glu Ile Val Glu Glu Arg Asp Glu Asn 
            420                 425                 430         


Pro Ala Lys Lys Ile Ala Met Thr Pro Asn Glu Leu Asp Leu Trp Ala 
        435                 440                 445             


Ile Arg Gly Ala Val Gln Arg Val Arg Asn Gln Ile Phe His Gln Gln 
    450                 455                 460                 


Ile Asn Lys Arg His Glu Pro Asn Gln Leu Lys Val Gly Ser Phe Glu 
465                 470                 475                 480 


Asn Gly Asp Leu Gly Asn Val Ser Tyr Gln Lys Thr Ile Tyr Gln Lys 
                485                 490                 495     


Leu Phe Asp Ala Glu Ile Lys Asp Ile Glu Ile Tyr Phe Ala Glu Lys 
            500                 505                 510         


Ile Lys Ser Ser Gly Ala Leu Glu Gln Tyr Ser Met Lys Asp Leu Glu 
        515                 520                 525             


Lys Leu Phe Ser Asn Lys Glu Leu Thr Leu Ser Leu Gly Gly Gln Val 
    530                 535                 540                 


Val Ala Phe Ala Pro Ser Tyr Lys Lys Leu Tyr Lys Gln Gly Tyr Phe 
545                 550                 555                 560 


Tyr Gln Asn Glu Lys Thr Ile Glu Leu Glu Gln Phe Thr Asp Tyr Asp 
                565                 570                 575     


Phe Ser Asn Asp Val Phe Lys Ala Asn Tyr Tyr Leu Ile Lys Leu Ile 
            580                 585                 590         


Tyr His Tyr Val Phe Leu Pro Gln Phe Ser Gln Ala Asn Asn Lys Leu 
        595                 600                 605             


Phe Lys Asp Thr Val His Tyr Val Ile Gln Gln Asn Lys Glu Leu Asn 
    610                 615                 620                 


Thr Thr Glu Lys Asp Lys Lys Asn Asn Lys Lys Ile Arg Lys Tyr Ala 
625                 630                 635                 640 


Phe Glu Gln Val Lys Leu Met Lys Asn Glu Ser Pro Glu Lys Tyr Met 
                645                 650                 655     


Gln Tyr Leu Gln Arg Glu Met Gln Glu Glu Arg Thr Ile Lys Glu Ala 
            660                 665                 670         


Lys Lys Thr Asn Glu Glu Lys Pro Asn Tyr Asn Phe Glu Lys Leu Leu 
        675                 680                 685             


Ile Gln Ile Phe Ile Lys Gly Phe Asp Thr Phe Leu Arg Asn Phe Asp 
    690                 695                 700                 


Leu Asn Leu Asn Pro Ala Glu Glu Leu Val Gly Thr Val Lys Glu Lys 
705                 710                 715                 720 


Ala Glu Gly Leu Arg Lys Arg Lys Glu Arg Ile Ala Lys Ile Leu Asn 
                725                 730                 735     


Val Asp Glu Gln Ile Lys Thr Gly Asp Glu Glu Ile Ala Phe Trp Ile 
            740                 745                 750         


Phe Ala Lys Leu Leu Asp Ala Arg His Leu Ser Glu Leu Arg Asn Glu 
        755                 760                 765             


Met Ile Lys Phe Lys Gln Ser Ser Val Lys Lys Gly Leu Ile Lys Asn 
    770                 775                 780                 


Gly Asp Leu Ile Glu Gln Met Gln Pro Ile Leu Glu Leu Cys Ile Leu 
785                 790                 795                 800 


Ser Asn Asp Ser Glu Ser Met Glu Lys Glu Ser Phe Asp Lys Ile Glu 
                805                 810                 815     


Val Phe Leu Glu Lys Val Glu Leu Ala Lys Asn Glu Pro Tyr Met Gln 
            820                 825                 830         


Glu Asp Lys Leu Thr Pro Val Lys Phe Arg Phe Met Lys Gln Leu Glu 
        835                 840                 845             


Lys Tyr Gln Thr Arg Asn Phe Ile Glu Asn Leu Val Ile Glu Asn Pro 
    850                 855                 860                 


Glu Phe Lys Val Ser Glu Lys Ile Val Leu Asn Trp His Glu Glu Lys 
865                 870                 875                 880 


Glu Lys Ile Ala Asp Leu Val Asp Lys Arg Thr Lys Leu His Glu Glu 
                885                 890                 895     


Trp Ala Ser Lys Ala Arg Glu Ile Glu Glu Tyr Asn Glu Lys Ile Lys 
            900                 905                 910         


Lys Asn Lys Ser Lys Lys Leu Asp Lys Pro Ala Glu Phe Ala Lys Phe 
        915                 920                 925             


Ala Glu Tyr Lys Ile Ile Cys Glu Ala Ile Glu Asn Phe Asn Arg Leu 
    930                 935                 940                 


Asp His Lys Val Arg Leu Thr Tyr Leu Lys Asn Leu His Tyr Leu Met 
945                 950                 955                 960 


Ile Asp Leu Met Gly Arg Met Val Gly Phe Ser Val Leu Phe Glu Arg 
                965                 970                 975     


Asp Phe Val Tyr Met Gly Arg Ser Tyr Ser Ala Leu Lys Lys Gln Ser 
            980                 985                 990         


Ile Tyr Leu Asn Asp Tyr Asp Thr  Phe Ala Asn Ile Arg  Asp Trp Glu 
        995                 1000                 1005             


Val Asn  Glu Asn Lys His Leu  Phe Gly Thr Ser Ser  Ser Asp Leu 
    1010                 1015                 1020             


Thr Phe  Gln Glu Thr Ala Glu  Phe Lys Asn Leu Lys  Lys Pro Met 
    1025                 1030                 1035             


Glu Asn  Gln Leu Lys Ala Leu  Leu Gly Val Thr Asn  His Ser Phe 
    1040                 1045                 1050             


Glu Ile  Arg Asn Asn Ile Ala  His Leu His Val Leu  Arg Asn Asp 
    1055                 1060                 1065             


Gly Lys  Gly Glu Gly Val Ser  Leu Leu Ser Cys Met  Asn Asp Leu 
    1070                 1075                 1080             


Arg Lys  Leu Met Ser Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Thr 
    1085                 1090                 1095             


Lys Ala  Ile Ile Lys Ile Leu  Asp Lys His Gly Met  Ile Leu Lys 
    1100                 1105                 1110             


Leu Thr  Asn Asn Asp His Thr  Lys Pro Phe Glu Ile  Glu Ser Leu 
    1115                 1120                 1125             


Lys Pro  Lys Lys Ile Ile His  Leu Glu Lys Ser Asn  His Ser Phe 
    1130                 1135                 1140             


Pro Met  Asp Gln Val Ser Gln  Glu Tyr Cys Asp Leu  Val Lys Lys 
    1145                 1150                 1155             


Met Leu  Val Phe Thr Asn 
    1160                 


<210>  29
<211>  1154
<212>  PRT
<213>  Paludibacter propionicigenes

<400>  29

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Ser Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Thr Leu Asn Lys Thr Ile Ile Lys Phe Asp 
    50                  55                  60                  


Thr Ala Lys Lys Gln Lys Leu Asn Val Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Lys Ala 
                85                  90                  95      


Glu Glu Ile Leu Pro Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Gln Ala Gln Asp Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Ala Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Lys Met Leu Gln Asp Val Lys Pro Leu Thr Asp Asp Lys Gly Lys Ile 
    210                 215                 220                 


Asn Thr Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Val Pro Asn Glu Ala Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ala His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr 
        355                 360                 365             


Asn Asp Ile Leu Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp 
    370                 375                 380                 


Asn Thr Asn Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Gly Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Lys Thr Val Phe Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Arg Phe 
    450                 455                 460                 


Ile Asn Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Val Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Gln Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ser Tyr Asn Ala Arg Tyr Phe Met Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Gly Phe Thr Thr Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys 
            580                 585                 590         


Gln Ala Glu Lys Val Asn Pro Arg Lys Lys Glu Ala Tyr Ala Phe Glu 
        595                 600                 605             


Ala Val Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala 
    610                 615                 620                 


Tyr Val Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys 
625                 630                 635                 640 


Val Ala Glu Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val 
                645                 650                 655     


Phe Ile Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe 
            660                 665                 670         


Val Gln Met Pro Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln 
        675                 680                 685             


Lys Ala Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys 
    690                 695                 700                 


Lys Leu Thr Pro Gln Tyr Ala Lys Ala Asp Asp Ala Thr His Ile Ala 
705                 710                 715                 720 


Phe Tyr Val Phe Cys Lys Leu Leu Asp Ala Ala His Leu Ser Asn Leu 
                725                 730                 735     


Arg Asn Glu Leu Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe 
            740                 745                 750         


His His Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val 
        755                 760                 765             


Val Pro Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu 
    770                 775                 780                 


Ala Arg Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp 
785                 790                 795                 800 


Ser Asp Leu Phe Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala 
                805                 810                 815     


Asn Ile Glu Leu Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln 
            820                 825                 830         


Ile Ile Asn Lys Asp Thr Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr 
        835                 840                 845             


Ala Trp Asn Thr Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg 
    850                 855                 860                 


Glu Asp His His Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys 
865                 870                 875                 880 


Glu Lys Gln Glu Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe 
                885                 890                 895     


Ile Glu Lys His Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn 
            900                 905                 910         


Thr Tyr Asn Trp Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg 
        915                 920                 925             


Leu His Gly Leu Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val 
    930                 935                 940                 


Ala Leu Phe Asp Arg Asp Phe Gln Phe Phe Asp Glu Gln Gln Ile Ala 
945                 950                 955                 960 


Asp Glu Phe Lys Leu His Gly Phe Val Asn Leu His Ser Ile Asp Lys 
                965                 970                 975     


Lys Leu Asn Glu Val Pro Thr Lys Lys Ile Lys Glu Ile Tyr Asp Ile 
            980                 985                 990         


Arg Asn Lys Ile Ile Gln Ile Asn  Gly Asn Lys Ile Asn  Glu Ser Val 
        995                 1000                 1005             


Arg Ala  Asn Leu Ile Gln Phe  Ile Ser Ser Lys Arg  Asn Tyr Tyr 
    1010                 1015                 1020             


Asn Asn  Ala Phe Leu His Val  Ser Asn Asp Glu Ile  Lys Glu Lys 
    1025                 1030                 1035             


Gln Met  Tyr Asp Ile Arg Asn  His Ile Ala His Phe  Asn Tyr Leu 
    1040                 1045                 1050             


Thr Lys  Asp Ala Ala Asp Phe  Ser Leu Ile Asp Leu  Ile Asn Glu 
    1055                 1060                 1065             


Leu Arg  Glu Leu Leu His Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1070                 1075                 1080             


Ser Lys  Ala Phe Ile Asp Leu  Phe Asp Lys His Gly  Met Ile Leu 
    1085                 1090                 1095             


Lys Leu  Lys Leu Asn Ala Asp  His Lys Leu Lys Val  Glu Ser Leu 
    1100                 1105                 1110             


Glu Pro  Lys Lys Ile Tyr His  Leu Gly Ser Ser Ala  Lys Asp Lys 
    1115                 1120                 1125             


Pro Glu  Tyr Gln Tyr Cys Thr  Asn Gln Val Met Met  Ala Tyr Cys 
    1130                 1135                 1140             


Asn Met  Cys Arg Ser Leu Leu  Glu Met Lys Lys 
    1145                 1150                 


<210>  30
<211>  970
<212>  PRT
<213>  Listeria weihenstephanensis

<400>  30

Met Leu Ala Leu Leu His Gln Glu Val Pro Ser Gln Lys Leu His Asn 
1               5                   10                  15      


Leu Lys Ser Leu Asn Thr Glu Ser Leu Thr Lys Leu Phe Lys Pro Lys 
            20                  25                  30          


Phe Gln Asn Met Ile Ser Tyr Pro Pro Ser Lys Gly Ala Glu His Val 
        35                  40                  45              


Gln Phe Cys Leu Thr Asp Ile Ala Val Pro Ala Ile Arg Asp Leu Asp 
    50                  55                  60                  


Glu Ile Lys Pro Asp Trp Gly Ile Phe Phe Glu Lys Leu Lys Pro Tyr 
65                  70                  75                  80  


Thr Asp Trp Ala Glu Ser Tyr Ile His Tyr Lys Gln Thr Thr Ile Gln 
                85                  90                  95      


Lys Ser Ile Glu Gln Asn Lys Ile Gln Ser Pro Asp Ser Pro Arg Lys 
            100                 105                 110         


Leu Val Leu Gln Lys Tyr Val Thr Ala Phe Leu Asn Gly Glu Pro Leu 
        115                 120                 125             


Gly Leu Asp Leu Val Ala Lys Lys Tyr Lys Leu Ala Asp Leu Ala Glu 
    130                 135                 140                 


Ser Phe Lys Val Val Asp Leu Asn Glu Asp Lys Ser Ala Asn Tyr Lys 
145                 150                 155                 160 


Ile Lys Ala Cys Leu Gln Gln His Gln Arg Asn Ile Leu Asp Glu Leu 
                165                 170                 175     


Lys Glu Asp Pro Glu Leu Asn Gln Tyr Gly Ile Glu Val Lys Lys Tyr 
            180                 185                 190         


Ile Gln Arg Tyr Phe Pro Ile Lys Arg Ala Pro Asn Arg Ser Lys His 
        195                 200                 205             


Ala Arg Ala Asp Phe Leu Lys Lys Glu Leu Ile Glu Ser Thr Val Glu 
    210                 215                 220                 


Gln Gln Phe Lys Asn Ala Val Tyr His Tyr Val Leu Glu Gln Gly Lys 
225                 230                 235                 240 


Met Glu Ala Tyr Glu Leu Thr Asp Pro Lys Thr Lys Asp Leu Gln Asp 
                245                 250                 255     


Ile Arg Ser Gly Glu Ala Phe Ser Phe Lys Phe Ile Asn Ala Cys Ala 
            260                 265                 270         


Phe Ala Ser Asn Asn Leu Lys Met Ile Leu Asn Pro Glu Cys Glu Lys 
        275                 280                 285             


Asp Ile Leu Gly Lys Gly Asp Phe Lys Lys Asn Leu Pro Asn Ser Thr 
    290                 295                 300                 


Thr Gln Ser Asp Val Val Lys Lys Met Ile Pro Phe Phe Ser Asp Glu 
305                 310                 315                 320 


Ile Gln Asn Val Asn Phe Asp Glu Ala Ile Trp Ala Ile Arg Gly Ser 
                325                 330                 335     


Ile Gln Gln Ile Arg Asn Glu Val Tyr His Cys Lys Lys His Ser Trp 
            340                 345                 350         


Lys Ser Ile Leu Lys Ile Lys Gly Phe Glu Phe Glu Pro Asn Asn Met 
        355                 360                 365             


Lys Tyr Thr Asp Ser Asp Met Gln Lys Leu Met Asp Lys Asp Ile Ala 
    370                 375                 380                 


Lys Ile Pro Asp Phe Ile Glu Glu Lys Leu Lys Ser Ser Gly Ile Ile 
385                 390                 395                 400 


Arg Phe Tyr Ser His Asp Lys Leu Gln Ser Ile Trp Glu Met Lys Gln 
                405                 410                 415     


Gly Phe Ser Leu Leu Thr Thr Asn Ala Pro Phe Val Pro Ser Phe Lys 
            420                 425                 430         


Arg Val Tyr Ala Lys Gly His Asp Tyr Gln Thr Ser Lys Asn Arg Tyr 
        435                 440                 445             


Tyr Asp Leu Gly Leu Thr Thr Phe Asp Ile Leu Glu Tyr Gly Glu Glu 
    450                 455                 460                 


Asp Phe Arg Ala Arg Tyr Phe Leu Thr Lys Leu Val Tyr Tyr Gln Gln 
465                 470                 475                 480 


Phe Met Pro Trp Phe Thr Ala Asp Asn Asn Ala Phe Arg Asp Ala Ala 
                485                 490                 495     


Asn Phe Val Leu Arg Leu Asn Lys Asn Arg Gln Gln Asp Ala Lys Ala 
            500                 505                 510         


Phe Ile Asn Ile Arg Glu Val Glu Glu Gly Glu Met Pro Arg Asp Tyr 
        515                 520                 525             


Met Gly Tyr Val Gln Gly Gln Ile Ala Ile His Glu Asp Ser Thr Glu 
    530                 535                 540                 


Asp Thr Pro Asn His Phe Glu Lys Phe Ile Ser Gln Val Phe Ile Lys 
545                 550                 555                 560 


Gly Phe Asp Ser His Met Arg Ser Ala Asp Leu Lys Phe Ile Lys Asn 
                565                 570                 575     


Pro Arg Asn Gln Gly Leu Glu Gln Ser Glu Ile Glu Glu Met Ser Phe 
            580                 585                 590         


Asp Ile Lys Val Glu Pro Ser Phe Leu Lys Asn Lys Asp Asp Tyr Ile 
        595                 600                 605             


Ala Phe Trp Thr Phe Cys Lys Met Leu Asp Ala Arg His Leu Ser Glu 
    610                 615                 620                 


Leu Arg Asn Glu Met Ile Lys Tyr Asp Gly His Leu Thr Gly Glu Gln 
625                 630                 635                 640 


Glu Ile Ile Gly Leu Ala Leu Leu Gly Val Asp Ser Arg Glu Asn Asp 
                645                 650                 655     


Trp Lys Gln Phe Phe Ser Ser Glu Arg Glu Tyr Glu Lys Ile Met Lys 
            660                 665                 670         


Gly Tyr Val Gly Glu Glu Leu Tyr Gln Arg Glu Pro Tyr Arg Gln Ser 
        675                 680                 685             


Asp Gly Lys Thr Pro Ile Leu Phe Arg Gly Val Glu Gln Ala Arg Lys 
    690                 695                 700                 


Tyr Gly Thr Glu Thr Val Ile Gln Arg Leu Phe Asp Ala Ser Pro Glu 
705                 710                 715                 720 


Phe Lys Val Ser Lys Cys Asn Ile Thr Glu Trp Glu Arg Gln Lys Glu 
                725                 730                 735     


Thr Ile Glu Glu Thr Ile Glu Arg Arg Lys Glu Leu His Asn Glu Trp 
            740                 745                 750         


Glu Lys Asn Pro Lys Lys Pro Gln Asn Asn Ala Phe Phe Lys Glu Tyr 
        755                 760                 765             


Lys Glu Cys Cys Asp Ala Ile Asp Ala Tyr Asn Trp His Lys Asn Lys 
    770                 775                 780                 


Thr Thr Leu Val Tyr Val Asn Glu Leu His His Leu Leu Ile Glu Ile 
785                 790                 795                 800 


Leu Gly Arg Tyr Val Gly Tyr Val Ala Ile Ala Asp Arg Asp Phe Gln 
                805                 810                 815     


Cys Met Ala Asn Gln Tyr Phe Lys His Ser Gly Ile Thr Glu Arg Val 
            820                 825                 830         


Glu Tyr Trp Gly Asp Asn Arg Leu Lys Ser Ile Lys Lys Leu Asp Thr 
        835                 840                 845             


Phe Leu Lys Lys Glu Gly Leu Phe Val Ser Glu Lys Asn Ala Arg Asn 
    850                 855                 860                 


His Ile Ala His Leu Asn Tyr Leu Ser Leu Lys Ser Glu Cys Thr Leu 
865                 870                 875                 880 


Leu Tyr Leu Ser Glu Arg Leu Arg Glu Ile Phe Lys Tyr Asp Arg Lys 
                885                 890                 895     


Leu Lys Asn Ala Val Ser Lys Ser Leu Ile Asp Ile Leu Asp Arg His 
            900                 905                 910         


Gly Met Ser Val Val Phe Ala Asn Leu Lys Glu Asn Lys His Arg Leu 
        915                 920                 925             


Val Ile Lys Ser Leu Glu Pro Lys Lys Leu Arg His Leu Gly Glu Lys 
    930                 935                 940                 


Lys Ile Asp Asn Gly Tyr Ile Glu Thr Asn Gln Val Ser Glu Glu Tyr 
945                 950                 955                 960 


Cys Gly Ile Val Lys Arg Leu Leu Glu Ile 
                965                 970 


<210>  31
<211>  1051
<212>  PRT
<213>  Listeria newyorkensis

<400>  31

Met Lys Ile Thr Lys Met Arg Val Asp Gly Arg Thr Ile Val Met Glu 
1               5                   10                  15      


Arg Thr Ser Lys Glu Gly Gln Leu Gly Tyr Glu Gly Ile Asp Gly Asn 
            20                  25                  30          


Lys Thr Thr Glu Ile Ile Phe Asp Lys Lys Lys Glu Ser Phe Tyr Lys 
        35                  40                  45              


Ser Ile Leu Asn Lys Thr Val Arg Lys Pro Asp Glu Lys Glu Lys Asn 
    50                  55                  60                  


Arg Arg Lys Gln Ala Ile Asn Lys Ala Ile Asn Lys Glu Ile Thr Glu 
65                  70                  75                  80  


Leu Met Leu Ala Val Leu His Gln Glu Val Pro Ser Gln Lys Leu His 
                85                  90                  95      


Asn Leu Lys Ser Leu Asn Thr Glu Ser Leu Thr Lys Leu Phe Lys Pro 
            100                 105                 110         


Lys Phe Gln Asn Met Ile Ser Tyr Pro Pro Ser Lys Gly Ala Glu His 
        115                 120                 125             


Val Gln Phe Cys Leu Thr Asp Ile Ala Val Pro Ala Ile Arg Asp Leu 
    130                 135                 140                 


Asp Glu Ile Lys Pro Asp Trp Gly Ile Phe Phe Glu Lys Leu Lys Pro 
145                 150                 155                 160 


Tyr Thr Asp Trp Ala Glu Ser Tyr Ile His Tyr Lys Gln Thr Thr Ile 
                165                 170                 175     


Gln Lys Ser Ile Glu Gln Asn Lys Ile Gln Ser Pro Asp Ser Pro Arg 
            180                 185                 190         


Lys Leu Val Leu Gln Lys Tyr Val Thr Ala Phe Leu Asn Gly Glu Pro 
        195                 200                 205             


Leu Gly Leu Asp Leu Val Ala Lys Lys Tyr Lys Leu Ala Asp Leu Ala 
    210                 215                 220                 


Glu Ser Phe Lys Leu Val Asp Leu Asn Glu Asp Lys Ser Ala Asn Tyr 
225                 230                 235                 240 


Lys Ile Lys Ala Cys Leu Gln Gln His Gln Arg Asn Ile Leu Asp Glu 
                245                 250                 255     


Leu Lys Glu Asp Pro Glu Leu Asn Gln Tyr Gly Ile Glu Val Lys Lys 
            260                 265                 270         


Tyr Ile Gln Arg Tyr Phe Pro Ile Lys Arg Ala Pro Asn Arg Ser Lys 
        275                 280                 285             


His Ala Arg Ala Asp Phe Leu Lys Lys Glu Leu Ile Glu Ser Thr Val 
    290                 295                 300                 


Glu Gln Gln Phe Lys Asn Ala Val Tyr His Tyr Val Leu Glu Gln Gly 
305                 310                 315                 320 


Lys Met Glu Ala Tyr Glu Leu Thr Asp Pro Lys Thr Lys Asp Leu Gln 
                325                 330                 335     


Asp Ile Arg Ser Gly Glu Ala Phe Ser Phe Lys Phe Ile Asn Ala Cys 
            340                 345                 350         


Ala Phe Ala Ser Asn Asn Leu Lys Met Ile Leu Asn Pro Glu Cys Glu 
        355                 360                 365             


Lys Asp Ile Leu Gly Lys Gly Asn Phe Lys Lys Asn Leu Pro Asn Ser 
    370                 375                 380                 


Thr Thr Arg Ser Asp Val Val Lys Lys Met Ile Pro Phe Phe Ser Asp 
385                 390                 395                 400 


Glu Leu Gln Asn Val Asn Phe Asp Glu Ala Ile Trp Ala Ile Arg Gly 
                405                 410                 415     


Ser Ile Gln Gln Ile Arg Asn Glu Val Tyr His Cys Lys Lys His Ser 
            420                 425                 430         


Trp Lys Ser Ile Leu Lys Ile Lys Gly Phe Glu Phe Glu Pro Asn Asn 
        435                 440                 445             


Met Lys Tyr Ala Asp Ser Asp Met Gln Lys Leu Met Asp Lys Asp Ile 
    450                 455                 460                 


Ala Lys Ile Pro Glu Phe Ile Glu Glu Lys Leu Lys Ser Ser Gly Val 
465                 470                 475                 480 


Val Arg Phe Tyr Arg His Asp Glu Leu Gln Ser Ile Trp Glu Met Lys 
                485                 490                 495     


Gln Gly Phe Ser Leu Leu Thr Thr Asn Ala Pro Phe Val Pro Ser Phe 
            500                 505                 510         


Lys Arg Val Tyr Ala Lys Gly His Asp Tyr Gln Thr Ser Lys Asn Arg 
        515                 520                 525             


Tyr Tyr Asn Leu Asp Leu Thr Thr Phe Asp Ile Leu Glu Tyr Gly Glu 
    530                 535                 540                 


Glu Asp Phe Arg Ala Arg Tyr Phe Leu Thr Lys Leu Val Tyr Tyr Gln 
545                 550                 555                 560 


Gln Phe Met Pro Trp Phe Thr Ala Asp Asn Asn Ala Phe Arg Asp Ala 
                565                 570                 575     


Ala Asn Phe Val Leu Arg Leu Asn Lys Asn Arg Gln Gln Asp Ala Lys 
            580                 585                 590         


Ala Phe Ile Asn Ile Arg Glu Val Glu Glu Gly Glu Met Pro Arg Asp 
        595                 600                 605             


Tyr Met Gly Tyr Val Gln Gly Gln Ile Ala Ile His Glu Asp Ser Ile 
    610                 615                 620                 


Glu Asp Thr Pro Asn His Phe Glu Lys Phe Ile Ser Gln Val Phe Ile 
625                 630                 635                 640 


Lys Gly Phe Asp Arg His Met Arg Ser Ala Asn Leu Lys Phe Ile Lys 
                645                 650                 655     


Asn Pro Arg Asn Gln Gly Leu Glu Gln Ser Glu Ile Glu Glu Met Ser 
            660                 665                 670         


Phe Asp Ile Lys Val Glu Pro Ser Phe Leu Lys Asn Lys Asp Asp Tyr 
        675                 680                 685             


Ile Ala Phe Trp Ile Phe Cys Lys Met Leu Asp Ala Arg His Leu Ser 
    690                 695                 700                 


Glu Leu Arg Asn Glu Met Ile Lys Tyr Asp Gly His Leu Thr Gly Glu 
705                 710                 715                 720 


Gln Glu Ile Ile Gly Leu Ala Leu Leu Gly Val Asp Ser Arg Glu Asn 
                725                 730                 735     


Asp Trp Lys Gln Phe Phe Ser Ser Glu Arg Glu Tyr Glu Lys Ile Met 
            740                 745                 750         


Lys Gly Tyr Val Val Glu Glu Leu Tyr Gln Arg Glu Pro Tyr Arg Gln 
        755                 760                 765             


Ser Asp Gly Lys Thr Pro Ile Leu Phe Arg Gly Val Glu Gln Ala Arg 
    770                 775                 780                 


Lys Tyr Gly Thr Glu Thr Val Ile Gln Arg Leu Phe Asp Ala Asn Pro 
785                 790                 795                 800 


Glu Phe Lys Val Ser Lys Cys Asn Leu Ala Glu Trp Glu Arg Gln Lys 
                805                 810                 815     


Glu Thr Ile Glu Glu Thr Ile Lys Arg Arg Lys Glu Leu His Asn Glu 
            820                 825                 830         


Trp Ala Lys Asn Pro Lys Lys Pro Gln Asn Asn Ala Phe Phe Lys Glu 
        835                 840                 845             


Tyr Lys Glu Cys Cys Asp Ala Ile Asp Ala Tyr Asn Trp His Lys Asn 
    850                 855                 860                 


Lys Thr Thr Leu Ala Tyr Val Asn Glu Leu His His Leu Leu Ile Glu 
865                 870                 875                 880 


Ile Leu Gly Arg Tyr Val Gly Tyr Val Ala Ile Ala Asp Arg Asp Phe 
                885                 890                 895     


Gln Cys Met Ala Asn Gln Tyr Phe Lys His Ser Gly Ile Thr Glu Arg 
            900                 905                 910         


Val Glu Tyr Trp Gly Asp Asn Arg Leu Lys Ser Ile Lys Lys Leu Asp 
        915                 920                 925             


Thr Phe Leu Lys Lys Glu Gly Leu Phe Val Ser Glu Lys Asn Ala Arg 
    930                 935                 940                 


Asn His Ile Ala His Leu Asn Tyr Leu Ser Leu Lys Ser Glu Cys Thr 
945                 950                 955                 960 


Leu Leu Tyr Leu Ser Glu Arg Leu Arg Glu Ile Phe Lys Tyr Asp Arg 
                965                 970                 975     


Lys Leu Lys Asn Ala Val Ser Lys Ser Leu Ile Asp Ile Leu Asp Arg 
            980                 985                 990         


His Gly Met Ser Val Val Phe Ala  Asn Leu Lys Glu Asn  Lys His Arg 
        995                 1000                 1005             


Leu Val  Ile Lys Ser Leu Glu  Pro Lys Lys Leu Arg  His Leu Gly 
    1010                 1015                 1020             


Gly Lys  Lys Ile Asp Gly Gly  Tyr Ile Glu Thr Asn  Gln Val Ser 
    1025                 1030                 1035             


Glu Glu  Tyr Cys Gly Ile Val  Lys Arg Leu Leu Glu  Met 
    1040                 1045                 1050     


<210>  32
<211>  1152
<212>  PRT
<213>  Leptotrichia wadei

<400>  32

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Ile Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Tyr Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp 
                565                 570                 575     


Ser Val Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Val Phe Phe Lys Ile Thr Asn Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly His Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Glu 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Ile Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Ser Asn Asn Asn Asn Asp Asn Asn Asp Ile 
    690                 695                 700                 


Phe Ser Lys Ile Lys Ile Lys Lys Asp Asn Lys Glu Lys Tyr Asp Lys 
705                 710                 715                 720 


Ile Leu Lys Asn Tyr Glu Lys His Asn Arg Asn Lys Glu Ile Pro His 
                725                 730                 735     


Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys 
            740                 745                 750         


Tyr Thr Glu Asn Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn 
        755                 760                 765             


His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser 
    770                 775                 780                 


Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu 
785                 790                 795                 800 


Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala 
                805                 810                 815     


Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Glu Asn Lys Ile Lys Asp 
            820                 825                 830         


Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly 
        835                 840                 845             


Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly 
    850                 855                 860                 


Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile 
865                 870                 875                 880 


Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu 
                885                 890                 895     


Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro 
            900                 905                 910         


Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys 
        915                 920                 925             


Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu 
    930                 935                 940                 


Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His 
945                 950                 955                 960 


Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg 
                965                 970                 975     


Leu Lys Gly Glu Phe Pro Glu Asn His Tyr Ile Glu Glu Ile Phe Asn 
            980                 985                 990         


Phe Asp Asn Ser Lys Asn Val Lys  Tyr Lys Ser Gly Gln  Ile Val Glu 
        995                 1000                 1005             


Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr Lys Asp  Asn Val Glu 
    1010                 1015                 1020             


Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val Lys Lys  Leu Lys Gln 
    1025                 1030                 1035             


Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr Ile Ala  His Phe Asn 
    1040                 1045                 1050             


Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu Glu Val  Leu Glu Asn 
    1055                 1060                 1065             


Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Ile 
    1070                 1075                 1080             


Met Lys  Ser Ile Val Asp Ile  Leu Lys Glu Tyr Gly  Phe Val Ala 
    1085                 1090                 1095             


Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile Glu Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Ser  Glu Lys Ile Val His  Leu Lys Asn Leu Lys  Lys Lys Lys 
    1115                 1120                 1125             


Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu Cys Glu  Leu Val Lys 
    1130                 1135                 1140             


Val Met  Phe Glu Tyr Lys Ala  Leu Glu 
    1145                 1150         


<210>  33
<211>  1285
<212>  PRT
<213>  Rhodobacter capsulatus

<400>  33

Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
1               5                   10                  15      


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
            20                  25                  30          


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
        35                  40                  45              


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
    50                  55                  60                  


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
65                  70                  75                  80  


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
                85                  90                  95      


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
            100                 105                 110         


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
        115                 120                 125             


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
    130                 135                 140                 


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
                165                 170                 175     


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
            180                 185                 190         


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
        195                 200                 205             


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
    210                 215                 220                 


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
225                 230                 235                 240 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
                245                 250                 255     


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
            260                 265                 270         


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
        275                 280                 285             


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
    290                 295                 300                 


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
305                 310                 315                 320 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
                325                 330                 335     


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
            340                 345                 350         


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
        355                 360                 365             


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
    370                 375                 380                 


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
385                 390                 395                 400 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
                405                 410                 415     


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
            420                 425                 430         


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
        435                 440                 445             


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
    450                 455                 460                 


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
465                 470                 475                 480 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
                485                 490                 495     


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
            500                 505                 510         


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
        515                 520                 525             


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
    530                 535                 540                 


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
545                 550                 555                 560 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
                565                 570                 575     


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
            580                 585                 590         


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
        595                 600                 605             


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
    610                 615                 620                 


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
625                 630                 635                 640 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
                645                 650                 655     


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Thr Ser Arg Leu Arg Pro 
            660                 665                 670         


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
        675                 680                 685             


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
    690                 695                 700                 


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
705                 710                 715                 720 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
                725                 730                 735     


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
        755                 760                 765             


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
    770                 775                 780                 


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
785                 790                 795                 800 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
                805                 810                 815     


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
            820                 825                 830         


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
        835                 840                 845             


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
    850                 855                 860                 


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
865                 870                 875                 880 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
                885                 890                 895     


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
            900                 905                 910         


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
        915                 920                 925             


Ala Glu Ile Glu Asp Glu Thr Gln Glu Lys Ser Gln Ile Val Ala Ala 
    930                 935                 940                 


Gln Glu Leu Arg Thr Asp Leu His Asp Lys Val Met Lys Cys His Pro 
945                 950                 955                 960 


Lys Thr Ile Ser Pro Glu Glu Arg Gln Ser Tyr Ala Ala Ala Ile Lys 
                965                 970                 975     


Thr Ile Glu Glu His Arg Phe Leu Val Gly Arg Val Tyr Leu Gly Asp 
            980                 985                 990         


His Leu Arg Leu His Arg Leu Met  Met Asp Val Ile Gly  Arg Leu Ile 
        995                 1000                 1005             


Asp Tyr  Ala Gly Ala Tyr Glu  Arg Asp Thr Gly Thr  Phe Leu Ile 
    1010                 1015                 1020             


Asn Ala  Ser Lys Gln Leu Gly  Ala Gly Ala Asp Trp  Ala Val Thr 
    1025                 1030                 1035             


Ile Ala  Gly Ala Ala Asn Thr  Asp Ala Arg Thr Gln  Thr Arg Lys 
    1040                 1045                 1050             


Asp Leu  Ala His Phe Asn Val  Leu Asp Arg Ala Asp  Gly Thr Pro 
    1055                 1060                 1065             


Asp Leu  Thr Ala Leu Val Asn  Arg Ala Arg Glu Met  Met Ala Tyr 
    1070                 1075                 1080             


Asp Arg  Lys Arg Lys Asn Ala  Val Pro Arg Ser Ile  Leu Asp Met 
    1085                 1090                 1095             


Leu Ala  Arg Leu Gly Leu Thr  Leu Lys Trp Gln Met  Lys Asp His 
    1100                 1105                 1110             


Leu Leu  Gln Asp Ala Thr Ile  Thr Gln Ala Ala Ile  Lys His Leu 
    1115                 1120                 1125             


Asp Lys  Val Arg Leu Thr Val  Gly Gly Pro Ala Ala  Val Thr Glu 
    1130                 1135                 1140             


Ala Arg  Phe Ser Gln Asp Tyr  Leu Gln Met Val Ala  Ala Val Phe 
    1145                 1150                 1155             


Asn Gly  Ser Val Gln Asn Pro  Lys Pro Arg Arg Arg  Asp Asp Gly 
    1160                 1165                 1170             


Asp Ala  Trp His Lys Pro Pro  Lys Pro Ala Thr Ala  Gln Ser Gln 
    1175                 1180                 1185             


Pro Asp  Gln Lys Pro Pro Asn  Lys Ala Pro Ser Ala  Gly Ser Arg 
    1190                 1195                 1200             


Leu Pro  Pro Pro Gln Val Gly  Glu Val Tyr Glu Gly  Val Val Val 
    1205                 1210                 1215             


Lys Val  Ile Asp Thr Gly Ser  Leu Gly Phe Leu Ala  Val Glu Gly 
    1220                 1225                 1230             


Val Ala  Gly Asn Ile Gly Leu  His Ile Ser Arg Leu  Arg Arg Ile 
    1235                 1240                 1245             


Arg Glu  Asp Ala Ile Ile Val  Gly Arg Arg Tyr Arg  Phe Arg Val 
    1250                 1255                 1260             


Glu Ile  Tyr Val Pro Pro Lys  Ser Asn Thr Ser Lys  Leu Asn Ala 
    1265                 1270                 1275             


Ala Asp  Leu Val Arg Ile Asp  
    1280                 1285 


<210>  34
<211>  1285
<212>  PRT
<213>  Rhodobacter capsulatus

<400>  34

Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
1               5                   10                  15      


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
            20                  25                  30          


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
        35                  40                  45              


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
    50                  55                  60                  


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
65                  70                  75                  80  


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
                85                  90                  95      


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
            100                 105                 110         


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
        115                 120                 125             


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
    130                 135                 140                 


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
                165                 170                 175     


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
            180                 185                 190         


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
        195                 200                 205             


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
    210                 215                 220                 


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
225                 230                 235                 240 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
                245                 250                 255     


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
            260                 265                 270         


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
        275                 280                 285             


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
    290                 295                 300                 


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
305                 310                 315                 320 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
                325                 330                 335     


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
            340                 345                 350         


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
        355                 360                 365             


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
    370                 375                 380                 


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
385                 390                 395                 400 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
                405                 410                 415     


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
            420                 425                 430         


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
        435                 440                 445             


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
    450                 455                 460                 


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
465                 470                 475                 480 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
                485                 490                 495     


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
            500                 505                 510         


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
        515                 520                 525             


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
    530                 535                 540                 


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
545                 550                 555                 560 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
                565                 570                 575     


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
            580                 585                 590         


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
        595                 600                 605             


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
    610                 615                 620                 


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
625                 630                 635                 640 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
                645                 650                 655     


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
            660                 665                 670         


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
        675                 680                 685             


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
    690                 695                 700                 


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
705                 710                 715                 720 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
                725                 730                 735     


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
        755                 760                 765             


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
    770                 775                 780                 


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
785                 790                 795                 800 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
                805                 810                 815     


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
            820                 825                 830         


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
        835                 840                 845             


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
    850                 855                 860                 


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
865                 870                 875                 880 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
                885                 890                 895     


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
            900                 905                 910         


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
        915                 920                 925             


Ala Glu Ile Glu Asp Glu Thr Gln Glu Lys Ser Gln Ile Val Ala Ala 
    930                 935                 940                 


Gln Glu Leu Arg Thr Asp Leu His Asp Lys Val Met Lys Cys His Pro 
945                 950                 955                 960 


Lys Thr Ile Ser Pro Glu Glu Arg Gln Ser Tyr Ala Ala Ala Ile Lys 
                965                 970                 975     


Thr Ile Glu Glu His Arg Phe Leu Val Gly Arg Val Tyr Leu Gly Asp 
            980                 985                 990         


His Leu Arg Leu His Arg Leu Met  Met Asp Val Ile Gly  Arg Leu Ile 
        995                 1000                 1005             


Asp Tyr  Ala Gly Ala Tyr Glu  Arg Asp Thr Gly Thr  Phe Leu Ile 
    1010                 1015                 1020             


Asn Ala  Ser Lys Gln Leu Gly  Ala Gly Ala Asp Trp  Ala Val Thr 
    1025                 1030                 1035             


Ile Ala  Gly Ala Ala Asn Thr  Asp Ala Arg Thr Gln  Thr Arg Lys 
    1040                 1045                 1050             


Asp Leu  Ala His Phe Asn Val  Leu Asp Arg Ala Asp  Gly Thr Pro 
    1055                 1060                 1065             


Asp Leu  Thr Ala Leu Val Asn  Arg Ala Arg Glu Met  Met Ala Tyr 
    1070                 1075                 1080             


Asp Arg  Lys Arg Lys Asn Ala  Val Pro Arg Ser Ile  Leu Asp Met 
    1085                 1090                 1095             


Leu Ala  Arg Leu Gly Leu Thr  Leu Lys Trp Gln Met  Lys Asp His 
    1100                 1105                 1110             


Leu Leu  Gln Asp Ala Thr Ile  Thr Gln Ala Ala Ile  Lys His Leu 
    1115                 1120                 1125             


Asp Lys  Val Arg Leu Thr Val  Gly Gly Pro Ala Ala  Val Thr Glu 
    1130                 1135                 1140             


Ala Arg  Phe Ser Gln Asp Tyr  Leu Gln Met Val Ala  Ala Val Phe 
    1145                 1150                 1155             


Asn Gly  Ser Val Gln Asn Pro  Lys Pro Arg Arg Arg  Asp Asp Gly 
    1160                 1165                 1170             


Asp Ala  Trp His Lys Pro Pro  Lys Pro Ala Thr Ala  Gln Ser Gln 
    1175                 1180                 1185             


Pro Asp  Gln Lys Pro Pro Asn  Lys Ala Pro Ser Ala  Gly Ser Arg 
    1190                 1195                 1200             


Leu Pro  Pro Pro Gln Val Gly  Glu Val Tyr Glu Gly  Val Val Val 
    1205                 1210                 1215             


Lys Val  Ile Asp Thr Gly Ser  Leu Gly Phe Leu Ala  Val Glu Gly 
    1220                 1225                 1230             


Val Ala  Gly Asn Ile Gly Leu  His Ile Ser Arg Leu  Arg Arg Ile 
    1235                 1240                 1245             


Arg Glu  Asp Ala Ile Ile Val  Gly Arg Arg Tyr Arg  Phe Arg Val 
    1250                 1255                 1260             


Glu Ile  Tyr Val Pro Pro Lys  Ser Asn Thr Ser Lys  Leu Asn Ala 
    1265                 1270                 1275             


Ala Asp  Leu Val Arg Ile Asp  
    1280                 1285 


<210>  35
<211>  1285
<212>  PRT
<213>  Rhodobacter capsulatus

<400>  35

Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
1               5                   10                  15      


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
            20                  25                  30          


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
        35                  40                  45              


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
    50                  55                  60                  


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
65                  70                  75                  80  


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
                85                  90                  95      


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
            100                 105                 110         


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
        115                 120                 125             


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
    130                 135                 140                 


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
                165                 170                 175     


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
            180                 185                 190         


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
        195                 200                 205             


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
    210                 215                 220                 


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
225                 230                 235                 240 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
                245                 250                 255     


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
            260                 265                 270         


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
        275                 280                 285             


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
    290                 295                 300                 


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
305                 310                 315                 320 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
                325                 330                 335     


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
            340                 345                 350         


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
        355                 360                 365             


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
    370                 375                 380                 


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
385                 390                 395                 400 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
                405                 410                 415     


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
            420                 425                 430         


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
        435                 440                 445             


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
    450                 455                 460                 


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
465                 470                 475                 480 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
                485                 490                 495     


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
            500                 505                 510         


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
        515                 520                 525             


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
    530                 535                 540                 


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
545                 550                 555                 560 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
                565                 570                 575     


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
            580                 585                 590         


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
        595                 600                 605             


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
    610                 615                 620                 


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
625                 630                 635                 640 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
                645                 650                 655     


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
            660                 665                 670         


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
        675                 680                 685             


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
    690                 695                 700                 


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
705                 710                 715                 720 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
                725                 730                 735     


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
        755                 760                 765             


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
    770                 775                 780                 


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
785                 790                 795                 800 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
                805                 810                 815     


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
            820                 825                 830         


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
        835                 840                 845             


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
    850                 855                 860                 


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
865                 870                 875                 880 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
                885                 890                 895     


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
            900                 905                 910         


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
        915                 920                 925             


Ala Glu Ile Glu Asp Glu Thr Gln Glu Lys Ser Gln Ile Val Ala Ala 
    930                 935                 940                 


Gln Glu Leu Arg Thr Asp Leu His Asp Lys Val Met Lys Cys His Pro 
945                 950                 955                 960 


Lys Thr Ile Ser Pro Glu Glu Arg Gln Ser Tyr Ala Ala Ala Ile Lys 
                965                 970                 975     


Thr Ile Glu Glu His Arg Phe Leu Val Gly Arg Val Tyr Leu Gly Asp 
            980                 985                 990         


His Leu Arg Leu His Arg Leu Met  Met Asp Val Ile Gly  Arg Leu Ile 
        995                 1000                 1005             


Asp Tyr  Ala Gly Ala Tyr Glu  Arg Asp Thr Gly Thr  Phe Leu Ile 
    1010                 1015                 1020             


Asn Ala  Ser Lys Gln Leu Gly  Ala Gly Ala Asp Trp  Ala Val Thr 
    1025                 1030                 1035             


Ile Ala  Gly Ala Ala Asn Thr  Asp Ala Arg Thr Gln  Thr Arg Lys 
    1040                 1045                 1050             


Asp Leu  Ala His Phe Asn Val  Leu Asp Arg Ala Asp  Gly Thr Pro 
    1055                 1060                 1065             


Asp Leu  Thr Ala Leu Val Asn  Arg Ala Arg Glu Met  Met Ala Tyr 
    1070                 1075                 1080             


Asp Arg  Lys Arg Lys Asn Ala  Val Pro Arg Ser Ile  Leu Asp Met 
    1085                 1090                 1095             


Leu Ala  Arg Leu Gly Leu Thr  Leu Lys Trp Gln Met  Lys Asp His 
    1100                 1105                 1110             


Leu Leu  Gln Asp Ala Thr Ile  Thr Gln Ala Ala Ile  Lys His Leu 
    1115                 1120                 1125             


Asp Lys  Val Arg Leu Thr Val  Gly Gly Pro Ala Ala  Val Thr Glu 
    1130                 1135                 1140             


Ala Arg  Phe Ser Gln Asp Tyr  Leu Gln Met Val Ala  Ala Val Phe 
    1145                 1150                 1155             


Asn Gly  Ser Val Gln Asn Pro  Lys Pro Arg Arg Arg  Asp Asp Gly 
    1160                 1165                 1170             


Asp Ala  Trp His Lys Pro Pro  Lys Pro Ala Thr Ala  Gln Ser Gln 
    1175                 1180                 1185             


Pro Asp  Gln Lys Pro Pro Asn  Lys Ala Pro Ser Ala  Gly Ser Arg 
    1190                 1195                 1200             


Leu Pro  Pro Pro Gln Val Gly  Glu Val Tyr Glu Gly  Val Val Val 
    1205                 1210                 1215             


Lys Val  Ile Asp Thr Gly Ser  Leu Gly Phe Leu Ala  Val Glu Gly 
    1220                 1225                 1230             


Val Ala  Gly Asn Ile Gly Leu  His Ile Ser Arg Leu  Arg Arg Ile 
    1235                 1240                 1245             


Arg Glu  Asp Ala Ile Ile Val  Gly Arg Arg Tyr Arg  Phe Arg Val 
    1250                 1255                 1260             


Glu Ile  Tyr Val Pro Pro Lys  Ser Asn Thr Ser Lys  Leu Asn Ala 
    1265                 1270                 1275             


Ala Asp  Leu Val Arg Ile Asp  
    1280                 1285 


<210>  36
<211>  1159
<212>  PRT
<213>  Leptotrichia buccalis

<400>  36

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val 
            820                 825                 830         


Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr 
        915                 920                 925             


Lys Gln Ala Ile Glu Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Glu Asn Lys Lys Asn  Val Lys Tyr Lys Gly  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp 
    1010                 1015                 1020             


Glu Val  Lys Ile Asn Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ile Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  37
<211>  1285
<212>  PRT
<213>  Rhodobacter capsulatus

<400>  37

Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
1               5                   10                  15      


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
            20                  25                  30          


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
        35                  40                  45              


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
    50                  55                  60                  


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
65                  70                  75                  80  


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
                85                  90                  95      


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
            100                 105                 110         


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
        115                 120                 125             


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
    130                 135                 140                 


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
                165                 170                 175     


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
            180                 185                 190         


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
        195                 200                 205             


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
    210                 215                 220                 


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
225                 230                 235                 240 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
                245                 250                 255     


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
            260                 265                 270         


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
        275                 280                 285             


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
    290                 295                 300                 


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
305                 310                 315                 320 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
                325                 330                 335     


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
            340                 345                 350         


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
        355                 360                 365             


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
    370                 375                 380                 


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
385                 390                 395                 400 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
                405                 410                 415     


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
            420                 425                 430         


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
        435                 440                 445             


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
    450                 455                 460                 


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
465                 470                 475                 480 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
                485                 490                 495     


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
            500                 505                 510         


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
        515                 520                 525             


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
    530                 535                 540                 


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
545                 550                 555                 560 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
                565                 570                 575     


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
            580                 585                 590         


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
        595                 600                 605             


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
    610                 615                 620                 


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
625                 630                 635                 640 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
                645                 650                 655     


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
            660                 665                 670         


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
        675                 680                 685             


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
    690                 695                 700                 


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
705                 710                 715                 720 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
                725                 730                 735     


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
        755                 760                 765             


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
    770                 775                 780                 


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
785                 790                 795                 800 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
                805                 810                 815     


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
            820                 825                 830         


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
        835                 840                 845             


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
    850                 855                 860                 


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
865                 870                 875                 880 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
                885                 890                 895     


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
            900                 905                 910         


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
        915                 920                 925             


Ala Glu Ile Glu Asp Glu Thr Gln Glu Lys Ser Gln Ile Val Ala Ala 
    930                 935                 940                 


Gln Glu Leu Arg Thr Asp Leu His Asp Lys Val Met Lys Cys His Pro 
945                 950                 955                 960 


Lys Thr Ile Ser Pro Glu Glu Arg Gln Ser Tyr Ala Ala Ala Ile Lys 
                965                 970                 975     


Thr Ile Glu Glu His Arg Phe Leu Val Gly Arg Val Tyr Leu Gly Asp 
            980                 985                 990         


His Leu Arg Leu His Arg Leu Met  Met Asp Val Ile Gly  Arg Leu Ile 
        995                 1000                 1005             


Asp Tyr  Ala Gly Ala Tyr Glu  Arg Asp Thr Gly Thr  Phe Leu Ile 
    1010                 1015                 1020             


Asn Ala  Ser Lys Gln Leu Gly  Ala Gly Ala Asp Trp  Ala Val Thr 
    1025                 1030                 1035             


Ile Ala  Gly Ala Ala Asn Thr  Asp Ala Arg Thr Gln  Thr Arg Lys 
    1040                 1045                 1050             


Asp Leu  Ala His Phe Asn Val  Leu Asp Arg Ala Asp  Gly Thr Pro 
    1055                 1060                 1065             


Asp Leu  Thr Ala Leu Val Asn  Arg Ala Arg Glu Met  Met Ala Tyr 
    1070                 1075                 1080             


Asp Arg  Lys Arg Lys Asn Ala  Val Pro Arg Ser Ile  Leu Asp Met 
    1085                 1090                 1095             


Leu Ala  Arg Leu Gly Leu Thr  Leu Lys Trp Gln Met  Lys Asp His 
    1100                 1105                 1110             


Leu Leu  Gln Asp Ala Thr Ile  Thr Gln Ala Ala Ile  Lys His Leu 
    1115                 1120                 1125             


Asp Lys  Val Arg Leu Thr Val  Gly Gly Pro Ala Ala  Val Thr Glu 
    1130                 1135                 1140             


Ala Arg  Phe Ser Gln Asp Tyr  Leu Gln Met Val Ala  Ala Val Phe 
    1145                 1150                 1155             


Asn Gly  Ser Val Gln Asn Pro  Lys Pro Arg Arg Arg  Asp Asp Gly 
    1160                 1165                 1170             


Asp Ala  Trp His Lys Pro Pro  Lys Pro Ala Thr Ala  Gln Ser Gln 
    1175                 1180                 1185             


Pro Asp  Gln Lys Pro Pro Asn  Lys Ala Pro Ser Ala  Gly Ser Arg 
    1190                 1195                 1200             


Leu Pro  Pro Pro Gln Val Gly  Glu Val Tyr Glu Gly  Val Val Val 
    1205                 1210                 1215             


Lys Val  Ile Asp Thr Gly Ser  Leu Gly Phe Leu Ala  Val Glu Gly 
    1220                 1225                 1230             


Val Ala  Gly Asn Ile Gly Leu  His Ile Ser Arg Leu  Arg Arg Ile 
    1235                 1240                 1245             


Arg Glu  Asp Ala Ile Ile Val  Gly Arg Arg Tyr Arg  Phe Arg Val 
    1250                 1255                 1260             


Glu Ile  Tyr Val Pro Pro Lys  Ser Asn Thr Ser Lys  Leu Asn Ala 
    1265                 1270                 1275             


Ala Asp  Leu Val Arg Ile Asp  
    1280                 1285 


<210>  38
<211>  1344
<212>  PRT
<213>  Eubacterium rectale

<400>  38

Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr Asn Val Phe Asn 
1               5                   10                  15      


Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn Asn Asp Glu Lys 
            20                  25                  30          


Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln Lys Asn Ile Lys 
        35                  40                  45              


Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys Tyr Val Glu Ser 
    50                  55                  60                  


Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser Tyr Arg Lys Ala 
65                  70                  75                  80  


Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp Ile Leu Lys Lys 
                85                  90                  95      


Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly Gly Lys Leu Glu 
            100                 105                 110         


Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val Val Ser Lys Tyr 
        115                 120                 125             


Asp Thr Gln Glu Phe Asp Ser Leu Ala Ala Met Val Val Phe Leu Glu 
    130                 135                 140                 


Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg Glu Ile Val Cys 
145                 150                 155                 160 


Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys Leu Asp Pro Asn 
                165                 170                 175     


Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser Val Arg Asn Gln 
            180                 185                 190         


Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu Phe Pro Gln Val 
        195                 200                 205             


Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn Val Glu Lys Glu 
    210                 215                 220                 


Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu Asp Asp Glu Lys 
225                 230                 235                 240 


Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu Asp Val Tyr Phe 
                245                 250                 255     


Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile Thr Leu Ser Asp 
            260                 265                 270         


Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys His Glu Cys Gly 
        275                 280                 285             


Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp Val Leu Met Glu 
    290                 295                 300                 


Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val Glu Lys Arg Glu 
305                 310                 315                 320 


Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn Ile Ile Cys Tyr 
                325                 330                 335     


Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser Asn Glu Pro Leu 
            340                 345                 350         


Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile His His Ile Glu 
        355                 360                 365             


Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala Gly Lys Leu Phe 
    370                 375                 380                 


Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp Lys Asp Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys Ala Val Tyr Asn 
                405                 410                 415     


Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn Lys Glu Leu Gly 
            420                 425                 430         


Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser Phe Asp Tyr Glu 
        435                 440                 445             


Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu Ala Val Asp Ile 
    450                 455                 460                 


Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys Asp Met Ser Asn 
465                 470                 475                 480 


Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys Arg Asn Asp Ile 
                485                 490                 495     


Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser Val Ser Ala Val 
            500                 505                 510         


Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile Asn Ile Phe Lys 
        515                 520                 525             


Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu Val Arg Phe Ile 
    530                 535                 540                 


Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn Glu Asn Phe His 
545                 550                 555                 560 


Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn Thr Glu Leu Phe 
                565                 570                 575     


Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu Asn Val Glu Lys 
            580                 585                 590         


Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr Gln Val Ser Glu 
        595                 600                 605             


Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser Val Ser Arg Ala 
    610                 615                 620                 


Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg Thr Ala Phe Pro 
625                 630                 635                 640 


Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro Ser Tyr Asp Ala 
                645                 650                 655     


Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys Glu 
            660                 665                 670         


Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala Leu Gln Leu Phe 
        675                 680                 685             


Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys Lys Gln Gln Arg 
    690                 695                 700                 


Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile Lys Ser Ala Cys 
705                 710                 715                 720 


Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr Glu Tyr Asn Gln 
                725                 730                 735     


Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Ile Phe 
            740                 745                 750         


Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu Lys Lys Ala Ile 
        755                 760                 765             


Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys Asp Leu Phe Gly 
    770                 775                 780                 


Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg Glu Ile Asp Lys 
785                 790                 795                 800 


Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr Glu Ala Leu Cys 
                805                 810                 815     


Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp Tyr Ile Val Gly 
            820                 825                 830         


Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val Gly Ser Met Arg 
        835                 840                 845             


Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg Ala Ala Ser Ile 
    850                 855                 860                 


Gly Asn Glu Leu His Val Ser Val His Asp Val Glu Lys Val Glu Lys 
865                 870                 875                 880 


Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala Ser Arg Thr Ser 
                885                 890                 895     


Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp Tyr Ala Arg Tyr 
            900                 905                 910         


Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met Pro Ser Glu Tyr 
        915                 920                 925             


Ser Ala Leu Val Asp Phe Ser Asn Glu Glu Gln Ser Asp Leu Tyr Val 
    930                 935                 940                 


Asp Pro Lys Asn Pro Lys Val Asn Arg Asn Ile Val His Ser Lys Leu 
945                 950                 955                 960 


Phe Ala Ala Asp His Ile Leu Arg Asp Ile Val Glu Pro Val Ser Lys 
                965                 970                 975     


Asp Asn Ile Glu Glu Phe Tyr Ser Gln Lys Ala Glu Ile Ala Tyr Cys 
            980                 985                 990         


Lys Ile Lys Gly Lys Glu Ile Thr  Ala Glu Glu Gln Lys  Ala Val Leu 
        995                 1000                 1005             


Lys Tyr  Gln Lys Leu Lys Asn  Arg Val Glu Leu Arg  Asp Ile Val 
    1010                 1015                 1020             


Glu Tyr  Gly Glu Ile Ile Asn  Glu Leu Leu Gly Gln  Leu Ile Asn 
    1025                 1030                 1035             


Trp Ser  Phe Met Arg Glu Arg  Asp Leu Leu Tyr Phe  Gln Leu Gly 
    1040                 1045                 1050             


Phe His  Tyr Asp Cys Leu Arg  Asn Asp Ser Lys Lys  Pro Glu Gly 
    1055                 1060                 1065             


Tyr Lys  Asn Ile Lys Val Asp  Glu Asn Ser Ile Lys  Asp Ala Ile 
    1070                 1075                 1080             


Leu Tyr  Gln Ile Ile Gly Met  Tyr Val Asn Gly Val  Thr Val Tyr 
    1085                 1090                 1095             


Ala Pro  Glu Lys Asp Gly Asp  Lys Leu Lys Glu Gln  Cys Val Lys 
    1100                 1105                 1110             


Gly Gly  Val Gly Val Lys Val  Ser Ala Phe His Arg  Tyr Ser Lys 
    1115                 1120                 1125             


Tyr Leu  Gly Leu Asn Glu Lys  Thr Leu Tyr Asn Ala  Gly Leu Glu 
    1130                 1135                 1140             


Ile Phe  Glu Val Val Ala Glu  His Glu Asp Ile Ile  Asn Leu Arg 
    1145                 1150                 1155             


Asn Gly  Ile Asp His Phe Lys  Tyr Tyr Leu Gly Asp  Tyr Arg Ser 
    1160                 1165                 1170             


Met Leu  Ser Ile Tyr Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr 
    1175                 1180                 1185             


Asp Ile  Lys Tyr Gln Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile 
    1190                 1195                 1200             


Leu Leu  Arg His Asn Val Ile  Val Glu Pro Ile Leu  Glu Ser Gly 
    1205                 1210                 1215             


Phe Lys  Thr Ile Gly Glu Gln  Thr Lys Pro Gly Ala  Lys Leu Ser 
    1220                 1225                 1230             


Ile Arg  Ser Ile Lys Ser Asp  Thr Phe Gln Tyr Lys  Val Lys Gly 
    1235                 1240                 1245             


Gly Thr  Leu Ile Thr Asp Ala  Lys Asp Glu Arg Tyr  Leu Glu Thr 
    1250                 1255                 1260             


Ile Arg  Lys Ile Leu Tyr Tyr  Ala Glu Asn Glu Glu  Asp Asn Leu 
    1265                 1270                 1275             


Lys Lys  Ser Val Val Val Thr  Asn Ala Asp Lys Tyr  Glu Lys Asn 
    1280                 1285                 1290             


Lys Glu  Ser Asp Asp Gln Asn  Lys Gln Lys Glu Lys  Lys Asn Lys 
    1295                 1300                 1305             


Asp Asn  Lys Gly Lys Lys Asn  Glu Glu Thr Lys Ser  Asp Ala Glu 
    1310                 1315                 1320             


Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn Pro Phe  Ala Asn Leu 
    1325                 1330                 1335             


Asn Phe  Lys Leu Ser Asn 
    1340                 


<210>  39
<211>  1285
<212>  PRT
<213>  Herbinix hemicellulosilytica

<400>  39

Met Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys 
1               5                   10                  15      


Ile Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp 
    50                  55                  60                  


Lys Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp 
65                  70                  75                  80  


Lys Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu 
                85                  90                  95      


Asp Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys 
            100                 105                 110         


Ala Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln 
        115                 120                 125             


Ala Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys 
    130                 135                 140                 


Glu Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys 
145                 150                 155                 160 


Ser Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu 
                165                 170                 175     


Val Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val 
            180                 185                 190         


Pro Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile 
        195                 200                 205             


Tyr Asp Tyr Asp Lys Leu Lys Ala Asn Ile Thr Asn Arg Leu Asp Lys 
    210                 215                 220                 


Thr Asp Lys Lys Ala Arg Ser Ile Ser Arg Ala Val Ser Glu Glu Leu 
225                 230                 235                 240 


Arg Glu Tyr His Lys Asn Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser 
                245                 250                 255     


Gly Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr 
            260                 265                 270         


Asn Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln 
        275                 280                 285             


Tyr Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser 
    290                 295                 300                 


Lys Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys 
305                 310                 315                 320 


Val Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp 
            340                 345                 350         


Thr Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys 
385                 390                 395                 400 


Phe Asp Asp Ile Thr Thr Lys Lys Ala Lys Glu Ala Ile Glu Ser Asn 
                405                 410                 415     


Tyr Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys 
            420                 425                 430         


Glu Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp 
        435                 440                 445             


Arg Pro Asp Asp Asp Ile Glu Asn Leu Ile Val Leu Val Lys Asn Ala 
    450                 455                 460                 


Ile Glu Ser Val Ser Tyr Leu Arg Asn Arg Thr Phe His Phe Lys Glu 
465                 470                 475                 480 


Ser Ser Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly 
                485                 490                 495     


Gln Asn Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Ala Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr 
    530                 535                 540                 


Cys Gly Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro 
545                 550                 555                 560 


Ala Phe Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr 
                565                 570                 575     


Ile Arg Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser 
            580                 585                 590         


Tyr Lys Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val 
        595                 600                 605             


Lys Asn Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu 
    610                 615                 620                 


Ile Tyr Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu 
625                 630                 635                 640 


Ile Thr Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr 
                645                 650                 655     


Glu Glu Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp 
            660                 665                 670         


Glu Asn Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro 
        675                 680                 685             


Asp Tyr Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg 
    690                 695                 700                 


Lys Gln Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn 
705                 710                 715                 720 


Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly 
                725                 730                 735     


Ala Tyr Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro 
            740                 745                 750         


Pro Leu Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu 
        755                 760                 765             


Phe Pro Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe 
    770                 775                 780                 


Ser Ile Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr 
785                 790                 795                 800 


Ser Ala Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys 
                805                 810                 815     


Lys Asn Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
            820                 825                 830         


Leu Leu Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys 
        835                 840                 845             


Tyr Arg Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Lys 
    850                 855                 860                 


Leu Glu Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu 
865                 870                 875                 880 


Leu Val Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala 
                885                 890                 895     


Glu Ser Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile 
            900                 905                 910         


Glu Lys Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His 
        915                 920                 925             


Ser Asp Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met 
    930                 935                 940                 


Arg Ser Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr 
945                 950                 955                 960 


Leu Ile Thr Lys Lys Glu Cys Leu Glu Tyr Ile Lys Leu Ser Asn Ile 
                965                 970                 975     


Ile Lys Asp Tyr Gln Asn Ser Leu Asn Glu Leu His Glu Gln Leu Glu 
            980                 985                 990         


Arg Ile Lys Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
        995                 1000                 1005             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1010                 1015                 1020             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1025                 1030                 1035             


Phe Glu  Ser Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1040                 1045                 1050             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1055                 1060                 1065             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1070                 1075                 1080             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1085                 1090                 1095             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1100                 1105                 1110             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1115                 1120                 1125             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1130                 1135                 1140             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1145                 1150                 1155             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1160                 1165                 1170             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1175                 1180                 1185             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1190                 1195                 1200             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1205                 1210                 1215             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1220                 1225                 1230             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1235                 1240                 1245             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1250                 1255                 1260             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1265                 1270                 1275             


Ser Ala  Asn Pro Lys His Thr  
    1280                 1285 


<210>  40
<211>  954
<212>  PRT
<213>  Eubacterium siraeum

<400>  40

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Pro Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Arg Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Ala His Trp Cys Val Ala Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Ala Asn Thr Val Cys Ala Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  41
<211>  930
<212>  PRT
<213>  unknown

<220>
<223>  uncultured Ruminococcus sp.

<400>  41

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Ala 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Ala Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys Leu Glu His His His His 
        915                 920                 925             


His His 
    930 


<210>  42
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) fluoro modified A

<400>  42
aaaucccccc                                                              10


<210>  43
<211>  10
<212>  RNA
<213>  artificial

<220>
<223>  Type III accessory nuclease activator


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2 (prime) fluoro modified A

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2 (prime) deoxycytidine modified C

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2 (prime) deoxycytidine modified C

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2 (prime) deoxycytidine modified C

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2 (prime) deoxycytidine modified C

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2 (prime) deoxycytidine modified C

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2 (prime) deoxycytidine modified C

<400>  43
aaaacccccc                                                              10


<210>  44
<211>  1437
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  44

Met Lys Ile Ser Lys Val Arg Glu Glu Asn Arg Gly Ala Lys Leu Thr 
1               5                   10                  15      


Val Asn Ala Lys Thr Ala Val Val Ser Glu Asn Arg Ser Gln Glu Gly 
            20                  25                  30          


Ile Leu Tyr Asn Asp Pro Ser Arg Tyr Gly Lys Ser Arg Lys Asn Asp 
        35                  40                  45              


Glu Asp Arg Asp Arg Tyr Ile Glu Ser Arg Leu Lys Ser Ser Gly Lys 
    50                  55                  60                  


Leu Tyr Arg Ile Phe Asn Glu Asp Lys Asn Lys Arg Glu Thr Asp Glu 
65                  70                  75                  80  


Leu Gln Trp Phe Leu Ser Glu Ile Val Lys Lys Ile Asn Arg Arg Asn 
                85                  90                  95      


Gly Leu Val Leu Ser Asp Met Leu Ser Val Asp Asp Arg Ala Phe Glu 
            100                 105                 110         


Lys Ala Phe Glu Lys Tyr Ala Glu Leu Ser Tyr Thr Asn Arg Arg Asn 
        115                 120                 125             


Lys Val Ser Gly Ser Pro Ala Phe Glu Thr Cys Gly Val Asp Ala Ala 
    130                 135                 140                 


Thr Ala Glu Arg Leu Lys Gly Ile Ile Ser Glu Thr Asn Phe Ile Asn 
145                 150                 155                 160 


Arg Ile Lys Asn Asn Ile Asp Asn Lys Val Ser Glu Asp Ile Ile Asp 
                165                 170                 175     


Arg Ile Ile Ala Lys Tyr Leu Lys Lys Ser Leu Cys Arg Glu Arg Val 
            180                 185                 190         


Lys Arg Gly Leu Lys Lys Leu Leu Met Asn Ala Phe Asp Leu Pro Tyr 
        195                 200                 205             


Ser Asp Pro Asp Ile Asp Val Gln Arg Asp Phe Ile Asp Tyr Val Leu 
    210                 215                 220                 


Glu Asp Phe Tyr His Val Arg Ala Lys Ser Gln Val Ser Arg Ser Ile 
225                 230                 235                 240 


Lys Asn Met Asn Met Pro Val Gln Pro Glu Gly Asp Gly Lys Phe Ala 
                245                 250                 255     


Ile Thr Val Ser Lys Gly Gly Thr Glu Ser Gly Asn Lys Arg Ser Ala 
            260                 265                 270         


Glu Lys Glu Ala Phe Lys Lys Phe Leu Ser Asp Tyr Ala Ser Leu Asp 
        275                 280                 285             


Glu Arg Val Arg Asp Asp Met Leu Arg Arg Met Arg Arg Leu Val Val 
    290                 295                 300                 


Leu Tyr Phe Tyr Gly Ser Asp Asp Ser Lys Leu Ser Asp Val Asn Glu 
305                 310                 315                 320 


Lys Phe Asp Val Trp Glu Asp His Ala Ala Arg Arg Val Asp Asn Arg 
                325                 330                 335     


Glu Phe Ile Lys Leu Pro Leu Glu Asn Lys Leu Ala Asn Gly Lys Thr 
            340                 345                 350         


Asp Lys Asp Ala Glu Arg Ile Arg Lys Asn Thr Val Lys Glu Leu Tyr 
        355                 360                 365             


Arg Asn Gln Asn Ile Gly Cys Tyr Arg Gln Ala Val Lys Ala Val Glu 
    370                 375                 380                 


Glu Asp Asn Asn Gly Arg Tyr Phe Asp Asp Lys Met Leu Asn Met Phe 
385                 390                 395                 400 


Phe Ile His Arg Ile Glu Tyr Gly Val Glu Lys Ile Tyr Ala Asn Leu 
                405                 410                 415     


Lys Gln Val Thr Glu Phe Lys Ala Arg Thr Gly Tyr Leu Ser Glu Lys 
            420                 425                 430         


Ile Trp Lys Asp Leu Ile Asn Tyr Ile Ser Ile Lys Tyr Ile Ala Met 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Tyr Ala Met Asp Glu Leu Asn Ala Ser Asp 
    450                 455                 460                 


Lys Lys Glu Ile Glu Leu Gly Lys Ile Ser Glu Glu Tyr Leu Ser Gly 
465                 470                 475                 480 


Ile Ser Ser Phe Asp Tyr Glu Leu Ile Lys Ala Glu Glu Met Leu Gln 
                485                 490                 495     


Arg Glu Thr Ala Val Tyr Val Ala Phe Ala Ala Arg His Leu Ser Ser 
            500                 505                 510         


Gln Thr Val Glu Leu Asp Ser Glu Asn Ser Asp Phe Leu Leu Leu Lys 
        515                 520                 525             


Pro Lys Gly Thr Met Asp Lys Asn Asp Lys Asn Lys Leu Ala Ser Asn 
    530                 535                 540                 


Asn Ile Leu Asn Phe Leu Lys Asp Lys Glu Thr Leu Arg Asp Thr Ile 
545                 550                 555                 560 


Leu Gln Tyr Phe Gly Gly His Ser Leu Trp Thr Asp Phe Pro Phe Asp 
                565                 570                 575     


Lys Tyr Leu Ala Gly Gly Lys Asp Asp Val Asp Phe Leu Thr Asp Leu 
            580                 585                 590         


Lys Asp Val Ile Tyr Ser Met Arg Asn Asp Ser Phe His Tyr Ala Thr 
        595                 600                 605             


Glu Asn His Asn Asn Gly Lys Trp Asn Lys Glu Leu Ile Ser Ala Met 
    610                 615                 620                 


Phe Glu His Glu Thr Glu Arg Met Thr Val Val Met Lys Asp Lys Phe 
625                 630                 635                 640 


Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Asn Asp Asp Leu Lys Lys 
                645                 650                 655     


Leu Leu Ile Asp Leu Tyr Lys Asp Asn Val Glu Arg Ala Ser Gln Val 
            660                 665                 670         


Pro Ser Phe Asn Lys Val Phe Val Arg Lys Asn Phe Pro Ala Leu Val 
        675                 680                 685             


Arg Asp Lys Asp Asn Leu Gly Ile Glu Leu Asp Leu Lys Ala Asp Ala 
    690                 695                 700                 


Asp Lys Gly Glu Asn Glu Leu Lys Phe Tyr Asn Ala Leu Tyr Tyr Met 
705                 710                 715                 720 


Phe Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Asn Asp Lys Asn Val Arg 
                725                 730                 735     


Glu Arg Phe Ile Thr Lys Ala Thr Lys Val Ala Asp Asn Tyr Asp Arg 
            740                 745                 750         


Asn Lys Glu Arg Asn Leu Lys Asp Arg Ile Lys Ser Ala Gly Ser Asp 
        755                 760                 765             


Glu Lys Lys Lys Leu Arg Glu Gln Leu Gln Asn Tyr Ile Ala Glu Asn 
    770                 775                 780                 


Asp Phe Gly Gln Arg Ile Lys Asn Ile Val Gln Val Asn Pro Asp Tyr 
785                 790                 795                 800 


Thr Leu Ala Gln Ile Cys Gln Leu Ile Met Thr Glu Tyr Asn Gln Gln 
                805                 810                 815     


Asn Asn Gly Cys Met Gln Lys Lys Ser Ala Ala Arg Lys Asp Ile Asn 
            820                 825                 830         


Lys Asp Ser Tyr Gln His Tyr Lys Met Leu Leu Leu Val Asn Leu Arg 
        835                 840                 845             


Lys Ala Phe Leu Glu Phe Ile Lys Glu Asn Tyr Ala Phe Val Leu Lys 
    850                 855                 860                 


Pro Tyr Lys His Asp Leu Cys Asp Lys Ala Asp Phe Val Pro Asp Phe 
865                 870                 875                 880 


Ala Lys Tyr Val Lys Pro Tyr Ala Gly Leu Ile Ser Arg Val Ala Gly 
                885                 890                 895     


Ser Ser Glu Leu Gln Lys Trp Tyr Ile Val Ser Arg Phe Leu Ser Pro 
            900                 905                 910         


Ala Gln Ala Asn His Met Leu Gly Phe Leu His Ser Tyr Lys Gln Tyr 
        915                 920                 925             


Val Trp Asp Ile Tyr Arg Arg Ala Ser Glu Thr Gly Thr Glu Ile Asn 
    930                 935                 940                 


His Ser Ile Ala Glu Asp Lys Ile Ala Gly Val Asp Ile Thr Asp Val 
945                 950                 955                 960 


Asp Ala Val Ile Asp Leu Ser Val Lys Leu Cys Gly Thr Ile Ser Ser 
                965                 970                 975     


Glu Ile Ser Asp Tyr Phe Lys Asp Asp Glu Val Tyr Ala Glu Tyr Ile 
            980                 985                 990         


Ser Ser Tyr Leu Asp Phe Glu Tyr  Asp Gly Gly Asn Tyr  Lys Asp Ser 
        995                 1000                 1005             


Leu Asn  Arg Phe Cys Asn Ser  Asp Ala Val Asn Asp  Gln Lys Val 
    1010                 1015                 1020             


Ala Leu  Tyr Tyr Asp Gly Glu  His Pro Lys Leu Asn  Arg Asn Ile 
    1025                 1030                 1035             


Ile Leu  Ser Lys Leu Tyr Gly  Glu Arg Arg Phe Leu  Glu Lys Ile 
    1040                 1045                 1050             


Thr Asp  Arg Val Ser Arg Ser  Asp Ile Val Glu Tyr  Tyr Lys Leu 
    1055                 1060                 1065             


Lys Lys  Glu Thr Ser Gln Tyr  Gln Thr Lys Gly Ile  Phe Asp Ser 
    1070                 1075                 1080             


Glu Asp  Glu Gln Lys Asn Ile  Lys Lys Phe Gln Glu  Met Lys Asn 
    1085                 1090                 1095             


Ile Val  Glu Phe Arg Asp Leu  Met Asp Tyr Ser Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Leu  Gln Gly Gln Leu Ile  Asn Trp Ile Tyr Leu  Arg Glu Arg 
    1115                 1120                 1125             


Asp Leu  Met Asn Phe Gln Leu  Gly Tyr His Tyr Ala  Cys Leu Asn 
    1130                 1135                 1140             


Asn Asp  Ser Asn Lys Gln Ala  Thr Tyr Val Thr Leu  Asp Tyr Gln 
    1145                 1150                 1155             


Gly Lys  Lys Asn Arg Lys Ile  Asn Gly Ala Ile Leu  Tyr Gln Ile 
    1160                 1165                 1170             


Cys Ala  Met Tyr Ile Asn Gly  Leu Pro Leu Tyr Tyr  Val Asp Lys 
    1175                 1180                 1185             


Asp Ser  Ser Glu Trp Thr Val  Ser Asp Gly Lys Glu  Ser Thr Gly 
    1190                 1195                 1200             


Ala Lys  Ile Gly Glu Phe Tyr  Arg Tyr Ala Lys Ser  Phe Glu Asn 
    1205                 1210                 1215             


Thr Ser  Asp Cys Tyr Ala Ser  Gly Leu Glu Ile Phe  Glu Asn Ile 
    1220                 1225                 1230             


Ser Glu  His Asp Asn Ile Thr  Glu Leu Arg Asn Tyr  Ile Glu His 
    1235                 1240                 1245             


Phe Arg  Tyr Tyr Ser Ser Phe  Asp Arg Ser Phe Leu  Gly Ile Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Arg 
    1265                 1270                 1275             


Lys Asn  Val Pro Thr Ile Leu  Tyr Asn Ile Leu Leu  Gln His Phe 
    1280                 1285                 1290             


Val Asn  Val Arg Phe Glu Phe  Val Ser Gly Lys Lys  Met Ile Gly 
    1295                 1300                 1305             


Ile Asp  Lys Lys Asp Arg Lys  Ile Ala Lys Glu Lys  Glu Cys Ala 
    1310                 1315                 1320             


Arg Ile  Thr Ile Arg Glu Lys  Asn Gly Val Tyr Ser  Glu Gln Phe 
    1325                 1330                 1335             


Thr Tyr  Lys Leu Lys Asn Gly  Thr Val Tyr Val Asp  Ala Arg Asp 
    1340                 1345                 1350             


Lys Arg  Tyr Leu Gln Ser Ile  Ile Arg Leu Leu Phe  Tyr Pro Glu 
    1355                 1360                 1365             


Lys Val  Asn Met Asp Glu Met  Ile Glu Val Lys Glu  Lys Lys Lys 
    1370                 1375                 1380             


Pro Ser  Asp Asn Asn Thr Gly  Lys Gly Tyr Ser Lys  Arg Asp Arg 
    1385                 1390                 1395             


Gln Gln  Asp Arg Lys Glu Tyr  Asp Lys Tyr Lys Glu  Lys Lys Lys 
    1400                 1405                 1410             


Lys Glu  Gly Asn Phe Leu Ser  Gly Met Gly Gly Asn  Ile Asn Trp 
    1415                 1420                 1425             


Asp Glu  Ile Asn Ala Gln Leu  Lys Asn 
    1430                 1435         


