                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       DiLillo, David
       Hermann, Aynur
       Kirshner, Jessica
       Olson, Kara
       Sineshchekova, Olga
       Smith, Eric
       Ullman, Erica
 
<120>  ANTIGEN-BINDING MOLECULES THAT BIND CD38 AND/OR CD28, AND USES 
       THEREOF

<130>  10786WO01

<140>  TBD
<141>  2021-09-17

<150>  63080172
<151>  2020-09-18

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga aaagtgataa cataggctat      180

gcggactctg tgaagggccg attcaccatt tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagccctt      300

gggggctgga agttcgacta ctattacggt atggacgttt ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  2
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Lys Ser Asp Asn Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Leu Gly Gly Trp Lys Phe Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggattcacct ttgatgatta tgcc                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
attagttgga aaagtgataa cata                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ile Ser Trp Lys Ser Asp Asn Ile 
1               5               


<210>  7
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gcaaaagccc ttgggggctg gaagttcgac tactattacg gtatggacgt t                51


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ala Lys Ala Leu Gly Gly Trp Lys Phe Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  9
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt caccttcagt aggaataata tgcactgggt ccgccaggct      120

ccagggaagg gactggaata tgtttcaggt attagtagta atgggggtcg cacatattat      180

gcagactctg tgaagggcag attcaccatc tccagagaca attccaagaa cacgctgtat      240

cttcaaatgg gcggcctgag agctgcggac atggctgtgt atttctgtac gagagatgac      300

gagctgcttt cctttgacta ctggggccag ggaaccctgg tcactgtctc ctca            354


<210>  10
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Asn Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Gly Leu Arg Ala Ala Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Asp Glu Leu Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
ggattcacct tcagtaggaa taat                                              24


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Phe Thr Phe Ser Arg Asn Asn 
1               5               


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
attagtagta atgggggtcg caca                                              24


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ile Ser Ser Asn Gly Gly Arg Thr 
1               5               


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
acgagagatg acgagctgct ttcctttgac tac                                    33


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Thr Arg Asp Asp Glu Leu Leu Ser Phe Asp Tyr 
1               5                   10      


<210>  17
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  18
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
cagagcatta gcagctat                                                     18


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  21
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gctgcatcc                                                                9


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Ala Ala Ser 
1           


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
caacagagtt acagtacccc tccgatcacc                                        30


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  25
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga aaagtgataa cataggctat      180

gcggactctg tgaagggccg attcaccatt tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagccctt      300

gggggctgga agttcgacta ctattacggt atggacgttt ggggccaagg gaccacggtc      360

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcgcc ctgctccagg      420

agcacctccg agagcacagc cgccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacgaaga cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagt ccaaatatgg tcccccatgc ccaccgtgcc cagcaccacc tgtggcagga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaggctca ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagtccc tctccctgtc tctgggtaaa tga                                  1353


<210>  26
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Lys Ser Asp Asn Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Leu Gly Gly Trp Lys Phe Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  27
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt caccttcagt aggaataata tgcactgggt ccgccaggct      120

ccagggaagg gactggaata tgtttcaggt attagtagta atgggggtcg cacatattat      180

gcagactctg tgaagggcag attcaccatc tccagagaca attccaagaa cacgctgtat      240

cttcaaatgg gcggcctgag agctgcggac atggctgtgt atttctgtac gagagatgac      300

gagctgcttt cctttgacta ctggggccag ggaaccctgg tcactgtctc ctcagcctct      360

acaaagggac cttctgtgtt tcctctggct ccttgttcta gatctacatc tgaatctaca      420

gctgctctgg gatgtctggt gaaggattat tttcctgaac ctgtgacagt gtcttggaat      480

tctggagctc tgacatctgg agtgcataca tttcctgctg tgctgcagtc ttctggactg      540

tattctctgt cttctgtggt gacagtgcct tcttcttctc tgggaacaaa gacatataca      600

tgtaatgtgg atcataagcc ttctaataca aaggtggata agagagtgga atctaagtat      660

ggacctcctt gtcctccttg tcctgctcct cctgtggctg gaccttctgt gtttctgttt      720

cctcctaagc ctaaggatac actgatgatc tctagaacac ctgaagtgac atgtgtggtg      780

gtggatgtgt ctcaggaaga tcctgaagtg cagtttaatt ggtatgtgga tggagtggaa      840

gtgcataatg ctaagacaaa gcctagagaa gaacagttta attctacata tagagtggtg      900

tctgtgctga cagtgctgca tcaggattgg ctgaatggaa aggaatataa gtgtaaggtg      960

tctaataagg gactgccttc ttctatcgaa aagacaatct ctaaggctaa gggacagcct     1020

agagaacctc aggtgtatac actgcctcct tctcaggaag aaatgacaaa gaatcaggtg     1080

tctctgacat gtctggtgaa gggattttat ccttctgata tcgctgtgga atgggaatct     1140

aatggacagc ctgaaaataa ttataagaca acacctcctg tgctggattc tgatggatct     1200

ttttttctgt attctagact gacagtggat aagtctagat ggcaggaagg aaatgtgttt     1260

tcttgttctg tgatgcatga agctctgcat aatagattta cacagaagtc tctgtctctg     1320

tctcctggaa agtag                                                      1335


<210>  28
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Asn Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Gly Leu Arg Ala Ala Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Asp Glu Leu Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg 
            420                 425                 430         


Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  29
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   648


<210>  30
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  31
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
caggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgtaagg cttctggagg ccccttcaga agttcttctt tcagctgggt gcgacaggcc      120

ccaggacaag ggcttgaatg gatgggaggg atcatcccta ttttaggtaa aacaaactat      180

gcacagaagt tccagggcag aatcacgatt gtcacggacg aatccacgac cacagtctac      240

atggaactga gcagcctgag atctgaggac acggccgttt tttactgtgt gagaggcagc      300

tcgctctttg actattgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  32
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Arg Ser Ser 
            20                  25                  30          


Ser Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Lys Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Ile Val Thr Asp Glu Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Val Arg Gly Ser Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
ggaggcccct tcagaagttc ttct                                              24


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Gly Gly Pro Phe Arg Ser Ser Ser 
1               5               


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
atcatcccta ttttaggtaa aaca                                              24


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Ile Ile Pro Ile Leu Gly Lys Thr 
1               5               


<210>  37
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
gtgagaggca gctcgctctt tgactat                                           27


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Val Arg Gly Ser Ser Leu Phe Asp Tyr 
1               5                   


<210>  39
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggatcac ccactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagatcca gttctccctg      240

aagctgagtt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag atggggggtt      300

cggagggact actactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  40
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ile Thr His Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ile Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Val Arg Arg Asp Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
ggtggctcca tcagtagtta ctac                                              24


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
atctattaca gtgggatcac c                                                 21


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Ile Tyr Tyr Ser Gly Ile Thr 
1               5           


<210>  45
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
gcgagatggg gggttcggag ggactactac tactacggta tggacgtc                    48


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Ala Arg Trp Gly Val Arg Arg Asp Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  47
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gaaatagttt tgacacagag tcccggcaca ctgtcactct ctcccgggga aagagccacc       60

ttgtcatgta gagcaagtca gtcagtctct agctcttatc tcgcctggta ccagcagaag      120

ccgggacagg cccctagact gctgatctac ggggcaagtt ccagggccac cggaatcccc      180

gaccggttca gtggaagcgg aagcggaacc gattttactt tgacgatttc tagactggag      240

ccagaggatt tcgccgttta ctattgtcaa cagtacggaa gcagcccgtg gacgtttggc      300

cagggcacga aggtagaaat caag                                             324


<210>  48
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
cagtcagtct ctagctctta t                                                 21


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  51
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
ggggcaagt                                                                9


<210>  52
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gly Ala Ser 
1           


<210>  53
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
caacagtacg gaagcagccc gtggacg                                           27


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  55
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
caggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgtaagg cttctggagg ccccttcaga agttcttctt tcagctgggt gcgacaggcc      120

ccaggacaag ggcttgaatg gatgggaggg atcatcccta ttttaggtaa aacaaactat      180

gcacagaagt tccagggcag aatcacgatt gtcacggacg aatccacgac cacagtctac      240

atggaactga gcagcctgag atctgaggac acggccgttt tttactgtgt gagaggcagc      300

tcgctctttg actattgggg ccagggaacc ctggtcaccg tctcctcagc ctccaccaag      360

ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagccgcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cgaagaccta cacctgcaac      600

gtagatcaca agcccagcaa caccaaggtg gacaagagag ttgagtccaa atatggtccc      660

ccatgcccac cgtgcccagc accacctgtg gcaggaccat cagtcttcct gttcccccca      720

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      780

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      960

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1020

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca ggctcaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacacaga agtccctctc cctgtctctg     1320

ggtaaatga                                                             1329


<210>  56
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Arg Ser Ser 
            20                  25                  30          


Ser Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Lys Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Ile Val Thr Asp Glu Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Val Arg Gly Ser Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  57
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggatcac ccactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagatcca gttctccctg      240

aagctgagtt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag atggggggtt      300

cggagggact actactacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctcagcct ctacaaaggg accttctgtg tttcctctgg ctccttgttc tagatctaca      420

tctgaatcta cagctgctct gggatgtctg gtgaaggatt attttcctga acctgtgaca      480

gtgtcttgga attctggagc tctgacatct ggagtgcata catttcctgc tgtgctgcag      540

tcttctggac tgtattctct gtcttctgtg gtgacagtgc cttcttcttc tctgggaaca      600

aagacatata catgtaatgt ggatcataag ccttctaata caaaggtgga taagagagtg      660

gaatctaagt atggacctcc ttgtcctcct tgtcctgctc ctcctgtggc tggaccttct      720

gtgtttctgt ttcctcctaa gcctaaggat acactgatga tctctagaac acctgaagtg      780

acatgtgtgg tggtggatgt gtctcaggaa gatcctgaag tgcagtttaa ttggtatgtg      840

gatggagtgg aagtgcataa tgctaagaca aagcctagag aagaacagtt taattctaca      900

tatagagtgg tgtctgtgct gacagtgctg catcaggatt ggctgaatgg aaaggaatat      960

aagtgtaagg tgtctaataa gggactgcct tcttctatcg aaaagacaat ctctaaggct     1020

aagggacagc ctagagaacc tcaggtgtat acactgcctc cttctcagga agaaatgaca     1080

aagaatcagg tgtctctgac atgtctggtg aagggatttt atccttctga tatcgctgtg     1140

gaatgggaat ctaatggaca gcctgaaaat aattataaga caacacctcc tgtgctggat     1200

tctgatggat ctttttttct gtattctaga ctgacagtgg ataagtctag atggcaggaa     1260

ggaaatgtgt tttcttgttc tgtgatgcat gaagctctgc ataatagatt tacacagaag     1320

tctctgtctc tgtctcctgg aaagtag                                         1347


<210>  58
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ile Thr His Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ile Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Val Arg Arg Asp Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  59
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
gaaatagttt tgacacagag tcccggcaca ctgtcactct ctcccgggga aagagccacc       60

ttgtcatgta gagcaagtca gtcagtctct agctcttatc tcgcctggta ccagcagaag      120

ccgggacagg cccctagact gctgatctac ggggcaagtt ccagggccac cggaatcccc      180

gaccggttca gtggaagcgg aagcggaacc gattttactt tgacgatttc tagactggag      240

ccagaggatt tcgccgttta ctattgtcaa cagtacggaa gcagcccgtg gacgtttggc      300

cagggcacga aggtagaaat caagcgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   648


<210>  60
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  61
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
    130                 135                 140                 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
145                 150                 155                 160 


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
                165                 170                 175     


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
            180                 185                 190         


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
        195                 200                 205             


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
    210                 215                 220                 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
225                 230                 235                 240 


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
                245                 250                 255     


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
            260                 265                 270         


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
        275                 280                 285             


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
    290                 295                 300                 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
305                 310                 315                 320 


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
                325                 330                 335     


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
            340                 345                 350         


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        355                 360                 365         


<210>  62
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Val Pro Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg 
1               5                   10                  15      


Phe Pro Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His 
            20                  25                  30          


Pro Glu Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys 
        35                  40                  45              


Gly Ala Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr 
    50                  55                  60                  


Gln Pro Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile 
65                  70                  75                  80  


Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val 
                85                  90                  95      


Gln Arg Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala 
            100                 105                 110         


Asp Asp Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr 
        115                 120                 125             


Gln Ser Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser 
    130                 135                 140                 


Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp 
145                 150                 155                 160 


Val Val His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys 
                165                 170                 175     


Asn Ser Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys 
            180                 185                 190         


Val Gln Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser 
        195                 200                 205             


Arg Asp Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile 
    210                 215                 220                 


Ser Lys Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp 
225                 230                 235                 240 


Lys Phe Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser 
                245                 250                 255     


Glu Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
            260                 265                 270         


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
        275                 280                 285             


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
305                 310                 315                 320 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
                325                 330                 335     


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
            340                 345                 350         


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
        355                 360                 365             


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
    370                 375                 380                 


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
385                 390                 395                 400 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
                405                 410                 415     


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
            420                 425                 430         


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
        435                 440                 445             


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
    450                 455                 460                 


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
465                 470                 475                 480 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490     


<210>  63
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


