                         SEQUENCE LISTING

<110>  REGENXBIO INC.
 
<120>  VECTORIZED ANTIBODIES FOR ANTI-VIRAL THERAPY

<130>  38013.0011P1

<140>  PCT/US2021/050565
<141>  2021-09-15

<150>  63/078,865
<151>  2020-09-15

<150>  63/106,848
<151>  2020-10-28

<160>  397   

<170>  PatentIn version 3.5

<210>  1
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  2
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  3
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  4
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  5
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  5

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  6
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  7
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  7

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  8
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  8

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  9
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  9
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagt                                                              969


<210>  10
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  10
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt                                      1050


<210>  11
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  11
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagt                                                             1089


<210>  12
<211>  1430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  12
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagcc cttaagctag caggttaatt tttaaaaagc      360

agtcaaaagt ccaagtggcc cttggcagca tttactctct ctgtttgctc tggttaataa      420

tctcaggagc acaaacattc cagatccagg ttaattttta aaaagcagtc aaaagtccaa      480

gtggcccttg gcagcattta ctctctctgt ttgctctggt taataatctc aggagcacaa      540

acattccaga tccggcgcgc cagggctgga agctaccttt gacatcattt cctctgcgaa      600

tgcatgtata atttctacag aacctattag aaaggatcac ccagcctctg cttttgtaca      660

actttccctt aaaaaactgc caattccact gctgtttggc ccaatagtga gaactttttc      720

ctgctgcctc ttggtgcttt tgcctatggc ccctattctg cctgctgaag acactcttgc      780

cagcatggac ttaaacccct ccagctctga caatcctctt tctcttttgt tttacatgaa      840

gggtctggca gccaaagcaa tcactcaaag ttcaaacctt atcatttttt gctttgttcc      900

tcttggcctt ggttttgtac atcagctttg aaaataccat cccagggtta atgctggggt      960

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag     1020

atgttgcttt ctgagaggat cttgctacca gtggaacagc cactaaggat tctgcagtga     1080

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1140

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1200

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1260

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1320

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1380

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1430


<210>  13
<211>  1318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  13
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagta aaacaggtaa gtccgctgtt tgtgtgctgc ctctgaagtc cacactgaac     1140

aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac     1200

acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggc     1260

ctctactaac catgttcatg ttttcttttt ttttctacag gtcctgggtg acgaacag       1318


<210>  14
<211>  1579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  14
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagt                                                  1579


<210>  15
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  15
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtctaga ggccgtccgc      360

cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg tggggagtta      420

tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa aaataactcc      480

cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac ggttcctcac      540

ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg gccgggcggt      600

gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag ctacccggag      660

gagcgggagg cgccaagcgt gagtatcgat cttgctacca gtggaacagc cactaaggat      720

tctgcagtga gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg      780

ccaccccctc caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct      840

ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg      900

ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg      960

accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat     1020

acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt     1080


<210>  16
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  16
gaatggtgga cacccaaata tggcgacggt tcctcacccg tcgccatatt tgggtgtccg       60

ccctcggccg gggccgcatt cctgggggcc gggcggtgct cccgcccgcc tcgataaaag      120

gctccggggc cggcggcggc ccacgagcta cccggaggag cgggaggcgc caagcgatct      180

tgctaccagt ggaacagcca ctaaggattc tgcagtgaga gcagagggcc agctaagtgg      240

tactctccca gagactgtct gactcacgcc accccctcca ccttggacac aggacgctgt      300

ggtttctgag ccaggtacag tgactccttt cggtaagtgc agtggaagct gtacactgcc      360

caggcaaagc gtccgggcag cgtaggcggg cgactcagat cccagccagt ggacttagcc      420

cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc agcctccccc      480

gttgcccctc tggatccact gcttaaatac ggacgaggac agggccctgt ctcctcagct      540

tcaggcacca ccactgacct gggacagt                                         568


<210>  17
<211>  895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  17
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagaa tggtggacac ccaaatatgg cgacggttcc      360

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg      420

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc      480

ggaggagcgg gaggcgccaa gcgatcttgc taccagtgga acagccacta aggattctgc      540

agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac tcacgccacc      600

ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacagtga ctcctttcgg      660

taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt aggcgggcga      720

ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg gggtgacctt      780

ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct taaatacgga      840

cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg acagt           895


<210>  18
<211>  895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  18
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagaa tggtggacac ccaaatatgg cgacggttcc      360

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg      420

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc      480

ggaggagcgg gaggcgccaa gcgatcttgc taccagtgga acagccacta aggattctgc      540

agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac tcacgccacc      600

ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacagtga ctcctttcgg      660

taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt aggcgggcga      720

ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg gggtgacctt      780

ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct taaatacgga      840

cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg acagt           895


<210>  19
<211>  1147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  19
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccctgcatg cgaagatctt cgaacaaggc tgtgggggac      360

tgagggcagg ctgtaacagg cttgggggcc agggcttata cgtgcctggg actcccaaag      420

tattactgtt ccatgttccc ggcgaagggc cagctgtccc ccgccagcta gactcagcac      480

ttagtttagg aaccagtgag caagtcagcc cttggggcag cccatacaag gccatggggc      540

tgggcaagct gcacgcctgg gtccggggtg ggcacggtgc ccgggcaacg agctgaaagc      600

tcatctgctc tcaggggccc ctccctgggg acagcccctc ctggctagtc acaccctgta      660

ggctcctcta tataacccag gggcacaggg gctgccctca ttctaccacc acctccacag      720

cacagacaga cactcaggag ccagccagcg tcgagatctt gctaccagtg gaacagccac      780

taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg      840

actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacagt      900

gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc      960

gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac     1020

tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg     1080

cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg     1140

ggacagt                                                               1147


<210>  20
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  20
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gcccttcaga ttaaaaataa ctgaggtaag ggcctgggta      360

ggggaggtgg tgtgagacgc tcctgtctct cctctatctg cccatcggcc ctttggggag      420

gaggaatgtg cccaaggact aaaaaaaggc catggagcca gaggggcgag ggcaacagac      480

ctttcatggg caaaccttgg ggccctgctg aagctttggc ccactacggg tttaggctgc      540

ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt aacccagaca      600

tgtggctgcc cccccccccc ccaacacctg ctgcctctaa aaataaccct gtccctggtg      660

gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg gactgagggc aggctgtaac      720

aggcttgggg gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt      780

cccggcgaag ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt      840

gagcaagtca gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc      900

tgggtccggg gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg      960

cccctccctg gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc     1020

caggggcaca ggggctgccc tcattctacc accacctcca cagcacagac agacactcag     1080

gagccagcca gcgtcgagat cttgctacca gtggaacagc cactaaggat tctgcagtga     1140

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1200

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1260

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1320

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1380

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1440

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1490


<210>  21
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  21
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210>  22
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  22
ggccgtccgc cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg       60

tggggagtta tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa      120

aaataactcc cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac      180

ggttcctcac ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg      240

gccgggcggt gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag      300

ctacccggag gagcgggagg cgccaagc                                         328


<210>  23
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  23
gaatggtgga cacccaaata tggcgacggt tcctcacccg tcgccatatt tgggtgtccg       60

ccctcggccg gggccgcatt cctgggggcc gggcggtgct cccgcccgcc tcgataaaag      120

gctccggggc cggcggcggc ccacgagcta cccggaggag cgggaggcgc caag            174


<210>  24
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  24

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


<210>  25
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV vector

<400>  25

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  26
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  26
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc                            100


<210>  27
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  27
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc aggttaattt ttaaaaagca      120

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      180

ctcaggagca caaacattcc                                                  200


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  28
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  29
<211>  554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  29
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctg                                                        554


<210>  30
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  30
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  31
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  31
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  32
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  32
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatc                                             144


<210>  33
<211>  288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  33
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatc                   288


<210>  34
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  34
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tc                                                          432


<210>  35
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  35
cccttcagat taaaaataac tgaggtaagg gcctgggtag gggaggtggt gtgagacgct       60

cctgtctctc ctctatctgc ccatcggccc tttggggagg aggaatgtgc ccaaggacta      120

aaaaaaggcc atggagccag aggggcgagg gcaacagacc tttcatgggc aaaccttggg      180

gccctgctga agctttggc                                                   199


<210>  36
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  36
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaag                     1725


<210>  37
<211>  865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  37
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tcccctgcat gcgaagatct tcgaacaagg ctgtggggga ctgagggcag      480

gctgtaacag gcttgggggc cagggcttat acgtgcctgg gactcccaaa gtattactgt      540

tccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca cttagtttag      600

gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg ctgggcaagc      660

tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag ctcatctgct      720

ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct      780

atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca gcacagacag      840

acactcagga gccagccagc gtcga                                            865


<210>  38
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  38
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210>  39
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  39
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  40
<211>  460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  40
gggctggaag ctacctttga catcatttcc tctgcgaatg catgtataat ttctacagaa       60

cctattagaa aggatcaccc agcctctgct tttgtacaac tttcccttaa aaaactgcca      120

attccactgc tgtttggccc aatagtgaga actttttcct gctgcctctt ggtgcttttg      180

cctatggccc ctattctgcc tgctgaagac actcttgcca gcatggactt aaacccctcc      240

agctctgaca atcctctttc tcttttgttt tacatgaagg gtctggcagc caaagcaatc      300

actcaaagtt caaaccttat cattttttgc tttgttcctc ttggccttgg ttttgtacat      360

cagctttgaa aataccatcc cagggttaat gctggggtta atttataact aagagtgctc      420

tagttttgca atacaggaca tgctataaaa atggaaagat                            460


<210>  41
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  41
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  42
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  42
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc ccagggctca       60

ctgtgggtct ctctgttcac ag                                                82


<210>  43
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  43
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  44
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  44
ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctca            55


<210>  45
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  45
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  46
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  46
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  47
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  47
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  48
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  48
gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caa                                              143


<210>  49
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  49
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                 110


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ynthetic construct; signal peptide

<400>  50

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  51
atgtatagga tgcaactgct cctcctgatt gctctgagcc tggctcttgt gaccaactct       60


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  52

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  53
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  53

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  54

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala 
        


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  55

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly 
        


<210>  56
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  56

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala 
            20                  25          


<210>  57
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  57

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  58

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser 
            20  


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  59

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly 
        


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  60

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly 
        


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  61

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr 
            


<210>  62
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  62

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser 
            20                  25                  30  


<210>  63
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  63

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala 
            20                  25      


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  64

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser 
        


<210>  65
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  65

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala 
            20              


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  66

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr 
        


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  67

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser 
            20  


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  68

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  69
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  69

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser 
            20                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  70

Met Ile Ser Arg Met Glu Lys Met Thr Met Met Met Lys Ile Leu Ile 
1               5                   10                  15      


Met Phe Ala Leu Gly Met Asn Tyr Trp Ser Cys Ser Gly 
            20                  25                  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  71

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  72

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  73

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  74
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  74

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly 
            20          


<210>  75
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  75

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  76
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  76

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly 
            20          


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  77

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly 
        


<210>  78
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  78

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala 
            20                  25          


<210>  79
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  79

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala 
            20          


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  80

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys 
            


<210>  81
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  81

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala 
            20              


<210>  82
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  82

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala 
            20  


<210>  83
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  83

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala 
            20              


<210>  84
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  84

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg 
            20                  25                  30      


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  85

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala 
1               5                   10                  15  


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  86

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  87

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala 
    


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  88

Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala 
1               5                   10                  15      


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  89

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala 
            20  


<210>  90
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  90

Gly Ser Gly 
1           


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  91

Arg Lys Arg Arg 
1               


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  92

Arg Arg Arg Arg 
1               


<210>  93
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  93
rrkr                                                                     4


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  94

Arg Lys Lys Arg 
1               


<210>  95
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  95

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  96
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  96

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  97
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  97

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  98
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  98

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  99
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  99

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  100
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  100

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  101
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  101

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  102
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  102

Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
1               5                   10                  15      


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25          


<210>  103
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  103

Arg Lys Arg Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  104
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  104

Arg Lys Arg Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210>  105
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  105

Arg Lys Arg Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
1               5                   10                  15      


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25              


<210>  106
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  106

Arg Lys Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe 
1               5                   10                  15      


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25                  30      


<210>  107
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  107
agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg ggatgttgaa       60

gagaatcctg ggcct                                                        75


<210>  108
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  108
agaaagagaa ga                                                           12


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  109
agaaagagaa gaggctctgg a                                                 21


<210>  110
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  110
ggctctgga                                                                9


<210>  111
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  111
gaaggcagag gctccctgct gacatgtggg gatgttgaag agaatcctgg gcct             54


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  112

Cys Pro Pro Cys Pro 
1               5   


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  113

Cys Pro Pro Cys Pro Ala 
1               5       


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  114

Cys Pro Pro Cys Ala 
1               5   


<210>  115
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  115

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  116
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  116

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  117

Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  118

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  119

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  120

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  121
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  121

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  122
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  122

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  123
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  123

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210>  124
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  124

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  125
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  125

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  126

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  127
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  127

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  128
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  128

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  129

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  130

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
1               5                   10              


<210>  131
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  131

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  132
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  132

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  133
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  133

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  134

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  135
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  135

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210>  136
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  136

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  137
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  137

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  138
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  138

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210>  139
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  139

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  140
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  140

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  141
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  141

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  142
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  142

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  143
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  143

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  144
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence


<220>
<221>  misc
<222>  (227)..(230)
<223>  can be present or absent

<220>
<221>  misc
<222>  (229)..(229)
<223>  Xaa can be Thr or Leu

<220>
<221>  misc
<222>  (231)..(236)
<223>  can be present or absent

<220>
<221>  misc
<222>  (237)..(247)
<223>  can be present or absent

<400>  144

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Ser Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Arg Arg Ile Gly Val Pro Arg Arg Asp Glu Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Xaa Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210>  145
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  146
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence


<220>
<221>  misc
<222>  (679)..(690)
<223>  can be present or absent

<220>
<221>  misc
<222>  (691)..(708)
<223>  can be present or absent

<220>
<221>  misc
<222>  (709)..(741)
<223>  can be present or absent

<400>  146
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc cactacatca tgatgtgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcggc atctacagca gcggcggcat caccgtgtac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc ctacaggagg      300

atcggcgtgc ccaggaggga cgagttcgac atctggggcc agggcaccat ggtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagagggtg      660

gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc cgagctgctg      720

ggcggcccca gcgtgttcct g                                                741


<210>  147
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  147
gacatccaga tgacccagag ccccagcacc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gagcatcagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacaag gccagcaccc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag cctgcagccc      240

gacgacttcg ccacctacta ctgccagcag tacaacacct actggacctt cggccagggc      300

accaaggtgg agatcaagag gaccgtggcc gcccccagcg tgttcatctt cccccccagc      360

gacgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      420

agggaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggacagc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg      600

agcagccccg tgaccaagag cttcaacagg ggcgagtgc                             639


<210>  148
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  148
atgtaccgga tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaatagc       60

gaagtccagc tgctggaatc tggcggcgga cttgttcaac ctggcggctc tctgagactg      120

agctgtgccg cttccggctt caccttcagc cactatatca tgatgtgggt ccgacaggcc      180

cctggcaaag gccttgaatg ggtgtccggc atctatagca gcggcggcat cacagtgtac      240

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      300

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcgc ctatagaaga      360

atcggcgtgc ccagacggga cgagttcgat atttggggcc agggcaccat ggtcaccgtg      420

tctagcgcct ctacaaaggg ccctagcgtg ttccctctgg ctcctagcag caagagcaca      480

agcggaggaa cagccgctct gggctgtctg gtcaaggact actttcccga gcctgtgacc      540

gtgtcctgga atagcggagc actgacaagc ggcgtgcaca cctttccagc tgtgctgcaa      600

agcagcggcc tgtactctct gagcagcgtg gtcacagtgc caagctctag cctgggcacc      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgcgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctc      780

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgcgt ggtggtggat gtgtcccacg aggatcccga agtgaagttc      900

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc     1080

atcagcaagg ccaagggcca gcctagggaa ccccaggttt acacactgcc tccaagccgg     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctcg tgaagggctt ctacccttcc     1200

gatatcgccg tggaatggga gagcaatggc cagccagaga acaactacaa gacaacccct     1260

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagtcc     1320

agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagtctgag cctgtctcca ggcctgcgga agagaagggc tcctgtgaag     1440

cagaccctga acttcgacct gctgaaactg gccggcgacg tggaaagcaa ccccggacct     1500

atgtatagaa tgcagctcct cctgctgatc gcactgagcc tggctctcgt gaccaacagc     1560

gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc     1620

atcacctgta gagccagcca gtccatctcc tcttggctgg cctggtatca gcaaaagcct     1680

ggcaaggccc ctaagctgct gatctacaag gcctccacac tggaaagcgg ggtgccctcc     1740

agattttctg gcagcggatc tggcaccgag ttcaccctga ccatcagtag cctgcagcct     1800

gacgacttcg ccacctacta ctgccagcag tacaatacct actggacctt cggccaggga     1860

acaaaggtgg aaatcaagcg gactgtggcc gctccaagcg tgttcatctt tccacctagc     1920

gacgagcagc tgaagtccgg cacagcctct gttgtgtgcc tgctgaacaa cttctacccc     1980

agagaagcca aggtgcagtg gaaagtggac aatgccctgc agagcggcaa ctcccaagag     2040

agcgtgacag agcaggactc caaggattcc acctacagcc tgtctagcac cctgacactg     2100

agcaaggccg actacgagaa gcacaaagtg tatgcctgcg aagtgaccca ccagggcctt     2160

agctctccag tgaccaagag cttcaaccgg ggcgagtgtt gataa                     2205


<210>  149
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  149
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      180

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      240

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      360

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagagcacc      480

agtggtggaa cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggggc tctgacttct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcaca      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcagaaaga gaagaggctc tggagaaggc     1440

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     1500

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     1560

acacagagcc cctccacact gtctgcatct gtgggagaca gagtgaccat cacctgtaga     1620

gccagccagt ctatctctag ctggctggcc tggtatcagc aaaagcctgg caaggcccct     1680

aagctgctga tctacaaggc cagcacactt gagtcagggg tgccctccag attttctggc     1740

tctggatctg gcacagagtt caccctgacc atcagctccc tgcagccaga tgactttgcc     1800

acctactact gccagcagta caatacctac tggacctttg gccagggaac aaaggtggaa     1860

atcaagagaa cagtggctgc cccatctgtg ttcatcttcc caccatctga tgaacagctg     1920

aagtctggca ctgcctctgt tgtgtgcctg ctgaacaact tttaccccag agaagccaag     1980

gtgcagtgga aagtggataa tgccctgcag tctggcaata gccaagaatc tgtgacagag     2040

caggactcca aggattccac ctacagcctg agcagcaccc tgacactgag caaggctgac     2100

tatgagaagc acaaagtgta tgcctgtgaa gtgacacacc agggactgag cagcccagtg     2160

accaagagct tcaacagggg agagtgctga taa                                  2193


<210>  150
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  150
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      180

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      240

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      360

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagagcacc      480

agtggtggaa cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggggc tctgacctct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcaca      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcagaaaga gaagaggatc aggggcccca     1440

gtgaagcaga ccctgaactt tgatctgctg aagctggctg gggatgttga gagcaaccct     1500

ggacctatgt ataggatgca actgctcctc ctgattgctc tgagcctggc tcttgtgacc     1560

aactctgaca tccagatgac acagagcccc tccacactgt ctgcatctgt gggagacaga     1620

gtgaccatca cctgtagagc cagccagtct atctcttcct ggctggcctg gtatcagcaa     1680

aagcctggca aggcccctaa gctgctgatc tacaaggcca gcacacttga gtcaggggtg     1740

ccctccagat tttctggctc tggatctggc acagagttca ccctgaccat cagctccctg     1800

cagccagatg actttgccac ctactactgc cagcagtaca atacctactg gacctttggc     1860

cagggaacaa aggtggaaat caagagaaca gtggctgccc catctgtgtt catcttccca     1920

ccatctgatg aacagctgaa gtctggcact gcctctgttg tgtgcctgct gaacaacttt     1980

taccctagag aagccaaggt gcagtggaaa gtggataatg ccctgcagtc tggcaatagc     2040

caagaatctg tgacagagca ggactccaag gattccacct acagcctgag cagcaccctg     2100

acactgagca aggctgacta tgagaagcac aaagtgtatg cctgtgaagt gacacaccag     2160

ggactgagca gcccagtgac caagagcttc aacaggggag agtgctgata a              2211


<210>  151
<211>  4196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  151
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgcta     1740

gcgggcactt tgcactggaa cttacaacac ccgagcaagg acgcgactct ccaccatgta     1800

ccggatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca atagcgaagt     1860

ccagctgctg gaatctggcg gcggacttgt tcaacctggc ggctctctga gactgagctg     1920

tgccgcttcc ggcttcacct tcagccacta tatcatgatg tgggtccgac aggcccctgg     1980

caaaggcctt gaatgggtgt ccggcatcta tagcagcggc ggcatcacag tgtacgccga     2040

ctctgtgaag ggcagattca ccatcagccg ggacaacagc aagaacaccc tgtacctgca     2100

gatgaacagc ctgagagccg aggacaccgc cgtgtactac tgcgcctata gaagaatcgg     2160

cgtgcccaga cgggacgagt tcgatatttg gggccagggc accatggtca ccgtgtctag     2220

cgcctctaca aagggcccta gcgtgttccc tctggctcct agcagcaaga gcacaagcgg     2280

aggaacagcc gctctgggct gtctggtcaa ggactacttt cccgagcctg tgaccgtgtc     2340

ctggaatagc ggagcactga caagcggcgt gcacaccttt ccagctgtgc tgcaaagcag     2400

cggcctgtac tctctgagca gcgtggtcac agtgccaagc tctagcctgg gcacccagac     2460

ctacatctgc aatgtgaacc acaagcctag caacaccaag gtggacaaga gagtggaacc     2520

caagagctgc gacaagaccc acacctgtcc tccatgtcct gctccagaac tgctcggcgg     2580

accttccgtg ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc     2640

tgaagtgacc tgcgtggtgg tggatgtgtc ccacgaggat cccgaagtga agttcaattg     2700

gtacgtggac ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa     2760

cagcacctac agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa     2820

agagtacaag tgcaaggtgt ccaacaaggc cctgcctgct cctatcgaga aaaccatcag     2880

caaggccaag ggccagccta gggaacccca ggtttacaca ctgcctccaa gccgggaaga     2940

gatgaccaag aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat     3000

cgccgtggaa tgggagagca atggccagcc agagaacaac tacaagacaa cccctcctgt     3060

gctggacagc gacggctcat tcttcctgta cagcaagctg acagtggaca agtccagatg     3120

gcagcagggc aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac     3180

ccagaagagt ctgagcctgt ctccaggcct gcggaagaga agggctcctg tgaagcagac     3240

cctgaacttc gacctgctga aactggccgg cgacgtggaa agcaaccccg gacctatgta     3300

tagaatgcag ctcctcctgc tgatcgcact gagcctggct ctcgtgacca acagcgacat     3360

ccagatgaca cagagcccca gcacactgtc tgccagcgtg ggagacagag tgaccatcac     3420

ctgtagagcc agccagtcca tctcctcttg gctggcctgg tatcagcaaa agcctggcaa     3480

ggcccctaag ctgctgatct acaaggcctc cacactggaa agcggggtgc cctccagatt     3540

ttctggcagc ggatctggca ccgagttcac cctgaccatc agtagcctgc agcctgacga     3600

cttcgccacc tactactgcc agcagtacaa tacctactgg accttcggcc agggaacaaa     3660

ggtggaaatc aagcggactg tggccgctcc aagcgtgttc atctttccac ctagcgacga     3720

gcagctgaag tccggcacag cctctgttgt gtgcctgctg aacaacttct accccagaga     3780

agccaaggtg cagtggaaag tggacaatgc cctgcagagc ggcaactccc aagagagcgt     3840

gacagagcag gactccaagg attccaccta cagcctgtct agcaccctga cactgagcaa     3900

ggccgactac gagaagcaca aagtgtatgc ctgcgaagtg acccaccagg gccttagctc     3960

tccagtgacc aagagcttca accggggcga gtgttgataa agcggccgcg gtacctctag     4020

agtcgacccg ggcggcctcg aggacggggt gaactacgcc tgaggatccg atctttttcc     4080

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     4140

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcg         4196


<210>  152
<211>  4106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  152
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccgccacca     1740

tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc accaattctg     1800

aggtccagct gcttgagagt ggtggtggac tggttcagcc tggtggcagc ctgagactgt     1860

cttgtgctgc ctctggcttc accttcagcc actatatcat gatgtgggtc agacaggccc     1920

ctggcaaagg cctggaatgg gtgtcaggca tctacagcag tggtggcatc acagtgtatg     1980

ctgactctgt gaagggcaga ttcaccatca gcagagacaa cagcaagaac accctgtacc     2040

tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc tatagaagaa     2100

ttggggtgcc cagaagggat gagtttgaca tctggggcca gggcaccatg gttacagtgt     2160

cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc aagagcacca     2220

gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag cctgtgactg     2280

tgtcctggaa ctctggggct ctgacctctg gggtgcacac ctttccagct gtgctgcagt     2340

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc ctgggcacac     2400

agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagagagtgg     2460

aacccaagag ctgtgacaag acccacacct gtcctccatg tcctgctcca gaactgcttg     2520

gaggcccttc tgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa     2580

cccctgaagt gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca     2640

attggtatgt ggatggggtt gaagtgcaca atgccaagac caagcctaga gaggaacagt     2700

acaacagcac ctacagagtg gtttctgtgc tgacagtgct gcaccaggac tggctgaatg     2760

gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gagaaaacca     2820

tctccaaggc caagggccag ccaagagaac cccaggttta caccctgcca cctagcagag     2880

aagagatgac caagaaccag gtgtccctga cctgcctggt taagggcttc tacccctctg     2940

acattgctgt ggaatgggag agcaatggcc agcctgaaaa caactacaag acaacccctc     3000

ctgtgctgga ctctgatggc tcattcttcc tgtacagcaa gctgactgtg gacaagtcca     3060

gatggcagca gggaaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact     3120

acacccagaa aagtctgtct ctgtcccctg gcagaaagag aagaggatca ggggccccag     3180

tgaagcagac cctgaacttt gatctgctga agctggctgg ggatgttgag agcaaccctg     3240

gacctatgta taggatgcaa ctgctcctcc tgattgctct gagcctggct cttgtgacca     3300

actctgacat ccagatgaca cagagcccct ccacactgtc tgcatctgtg ggagacagag     3360

tgaccatcac ctgtagagcc agccagtcta tctcttcctg gctggcctgg tatcagcaaa     3420

agcctggcaa ggcccctaag ctgctgatct acaaggccag cacacttgag tcaggggtgc     3480

cctccagatt ttctggctct ggatctggca cagagttcac cctgaccatc agctccctgc     3540

agccagatga ctttgccacc tactactgcc agcagtacaa tacctactgg acctttggcc     3600

agggaacaaa ggtggaaatc aagagaacag tggctgcccc atctgtgttc atcttcccac     3660

catctgatga acagctgaag tctggcactg cctctgttgt gtgcctgctg aacaactttt     3720

accctagaga agccaaggtg cagtggaaag tggataatgc cctgcagtct ggcaatagcc     3780

aagaatctgt gacagagcag gactccaagg attccaccta cagcctgagc agcaccctga     3840

cactgagcaa ggctgactat gagaagcaca aagtgtatgc ctgtgaagtg acacaccagg     3900

gactgagcag cccagtgacc aagagcttca acaggggaga gtgctgataa ctcgaggacg     3960

gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat ggggacatca     4020

tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag     4080

tgtgttggaa ttttttgtgt ctctca                                          4106


<210>  153
<211>  4092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  153
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccgccacca     1740

tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc accaattctg     1800

aggtccagct gcttgagagt ggtggtggac tggttcagcc tggtggcagc ctgagactgt     1860

cttgtgctgc ctctggcttc accttcagcc actatatcat gatgtgggtc agacaggccc     1920

ctggcaaagg cctggaatgg gtgtcaggca tctacagcag tggtggcatc acagtgtatg     1980

ctgactctgt gaagggcaga ttcaccatca gcagagacaa cagcaagaac accctgtacc     2040

tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc tatagaagaa     2100

ttggggtgcc cagaagggat gagtttgaca tctggggcca gggcaccatg gttacagtgt     2160

cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc aagagcacca     2220

gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag cctgtgactg     2280

tgtcctggaa ctctggggct ctgacttctg gggtgcacac ctttccagct gtgctgcagt     2340

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc ctgggcacac     2400

agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagagagtgg     2460

aacccaagag ctgtgacaag acccacacct gtcctccatg tcctgctcca gaactgcttg     2520

gaggcccttc tgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa     2580

cccctgaagt gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca     2640

attggtatgt ggatggggtt gaagtgcaca atgccaagac caagcctaga gaggaacagt     2700

acaacagcac ctacagagtg gtttctgtgc tgacagtgct gcaccaggac tggctgaatg     2760

gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gagaaaacca     2820

tctccaaggc caagggccag ccaagagaac cccaggttta caccctgcca cctagcagag     2880

aagagatgac caagaaccag gtgtccctga cctgcctggt taagggcttc tacccctctg     2940

acattgctgt ggaatgggag agcaatggcc agcctgaaaa caactacaag acaacccctc     3000

ctgtgctgga ctctgatggc tcattcttcc tgtacagcaa gctgactgtg gacaagtcca     3060

gatggcagca gggaaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact     3120

acacccagaa aagtctgtct ctgtcccctg gcagaaagag aagaggctct ggagaaggca     3180

gaggctccct gctgacatgt ggggatgttg aagagaatcc tgggcctatg tataggatgc     3240

aactgctcct cctgattgct ctgagcctgg ctcttgtgac caactctgac atccagatga     3300

cacagagccc ctccacactg tctgcatctg tgggagacag agtgaccatc acctgtagag     3360

ccagccagtc tatctctagc tggctggcct ggtatcagca aaagcctggc aaggccccta     3420

agctgctgat ctacaaggcc agcacacttg agtcaggggt gccctccaga ttttctggct     3480

ctggatctgg cacagagttc accctgacca tcagctccct gcagccagat gactttgcca     3540

cctactactg ccagcagtac aatacctact ggacctttgg ccagggaaca aaggtggaaa     3600

tcaagagaac agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga     3660

agtctggcac tgcctctgtt gtgtgcctgc tgaacaactt ttaccccaga gaagccaagg     3720

tgcagtggaa agtggataat gccctgcagt ctggcaatag ccaagaatct gtgacagagc     3780

aggactccaa ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact     3840

atgagaagca caaagtgtat gcctgtgaag tgacacacca gggactgagc agcccagtga     3900

ccaagagctt caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag     3960

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4020

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4080

gtctctcact cg                                                         4092


<210>  154
<211>  3397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  154
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagagacag ctttattgcg gtagtttatc      720

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca      780

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag      840

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      900

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt      960

acagctctta aggctagagt acttaatacg actcactata ggctagcctc gagaattcac     1020

gcgtgccgcc accatgtaca gaatgcagct gctgctgctc attgccctgt ctctggccct     1080

ggtcaccaat tctgaggtcc agctgcttga gagtggtggt ggactggttc agcctggtgg     1140

cagcctgaga ctgtcttgtg ctgcctctgg cttcaccttc agccactata tcatgatgtg     1200

ggtcagacag gcccctggca aaggcctgga atgggtgtca ggcatctaca gcagtggtgg     1260

catcacagtg tatgctgact ctgtgaaggg cagattcacc atcagcagag acaacagcaa     1320

gaacaccctg tacctgcaga tgaactccct gagagctgag gacacagcag tgtactactg     1380

tgcctataga agaattgggg tgcccagaag ggatgagttt gacatctggg gccagggcac     1440

catggttaca gtgtcctctg ccagcacaaa gggcccctct gtttttccac tggctcccag     1500

cagcaagagc accagtggtg gaacagctgc cctgggctgt ctggtcaagg attacttccc     1560

tgagcctgtg actgtgtcct ggaactctgg ggctctgact tctggggtgc acacctttcc     1620

agctgtgctg cagtcctctg gcctgtactc tctgtcctct gtggtcacag tgcctagctc     1680

tagcctgggc acacagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt     1740

ggacaagaga gtggaaccca agagctgtga caagacccac acctgtcctc catgtcctgc     1800

tccagaactg cttggaggcc cttctgtgtt cctgtttcct ccaaagccta aggacaccct     1860

gatgatcagc agaacccctg aagtgacctg tgtggtggtt gatgtgtccc atgaggaccc     1920

agaagtgaag ttcaattggt atgtggatgg ggttgaagtg cacaatgcca agaccaagcc     1980

tagagaggaa cagtacaaca gcacctacag agtggtttct gtgctgacag tgctgcacca     2040

ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc     2100

tattgagaaa accatctcca aggccaaggg ccagccaaga gaaccccagg tttacaccct     2160

gccacctagc agagaagaga tgaccaagaa ccaggtgtcc ctgacctgcc tggttaaggg     2220

cttctacccc tctgacattg ctgtggaatg ggagagcaat ggccagcctg aaaacaacta     2280

caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtaca gcaagctgac     2340

tgtggacaag tccagatggc agcagggaaa tgtgttcagc tgctctgtga tgcatgaggc     2400

cctgcacaac cactacaccc agaaaagtct gtctctgtcc cctggcagaa agagaagagg     2460

ctctggagaa ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc     2520

tatgtatagg atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc     2580

tgacatccag atgacacaga gcccctccac actgtctgca tctgtgggag acagagtgac     2640

catcacctgt agagccagcc agtctatctc tagctggctg gcctggtatc agcaaaagcc     2700

tggcaaggcc cctaagctgc tgatctacaa ggccagcaca cttgagtcag gggtgccctc     2760

cagattttct ggctctggat ctggcacaga gttcaccctg accatcagct ccctgcagcc     2820

agatgacttt gccacctact actgccagca gtacaatacc tactggacct ttggccaggg     2880

aacaaaggtg gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc     2940

tgatgaacag ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttttaccc     3000

cagagaagcc aaggtgcagt ggaaagtgga taatgccctg cagtctggca atagccaaga     3060

atctgtgaca gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact     3120

gagcaaggct gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact     3180

gagcagccca gtgaccaaga gcttcaacag gggagagtgc tgataagtcg acccgggcgg     3240

cctcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     3300

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3360

cattgcaata gtgtgttgga attttttgtg tctctca                              3397


<210>  155
<211>  3226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  155
ggctcagagg cacacaggag tttctgggct caccctgccc ccttccaacc cctcagttcc       60

catcctccag cagctgtttg tgtgctgcct ctgaagtcca cactgaacaa acttcagcct      120

actcatgtcc ctaaaatggg caaacattgc aagcagcaaa cagcaaacac acagccctcc      180

ctgcctgctg accttggagc tggggcagag gtcagagacc tctctgggcc catgccacct      240

ccaacatcca ctcgacccct tggaatttcg gtggagagga gcagaggttg tcctggcgtg      300

gtttaggtag tgtgagaggg gtacccgggg atcttgctac cagtggaaca gccactaagg      360

attctgcagt gagagcagag ggccagctaa gtggtactct cccagagact gtctgactca      420

cgccaccccc tccaccttgg acacaggacg ctgtggtttc tgagccaggt acaatgactc      480

ctttcggtaa gtgcagtgga agctgtacac tgcccaggca aagcgtccgg gcagcgtagg      540

cgggcgactc agatcccagc cagtggactt agcccctgtt tgctcctccg ataactgggg      600

tgaccttggt taatattcac cagcagcctc ccccgttgcc cctctggatc cactgcttaa      660

atacggacga ggacagggcc ctgtctcctc agcttcaggc accaccactg acctgggaca      720

gtcaggtaag tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcttgt      780

cgagacagag aagactcttg cgtttctgat aggcacctat tggtcttact gacatccact      840

ttgcctttct ctccacaggt tcgaattcgc cgccaccatg tacagaatgc agctgctgct      900

gctcattgcc ctgtctctgg ccctggtcac caattctgag gtccagctgc ttgagagtgg      960

tggtggactg gttcagcctg gtggcagcct gagactgtct tgtgctgcct ctggcttcac     1020

cttcagccac tatatcatga tgtgggtcag acaggcccct ggcaaaggcc tggaatgggt     1080

gtcaggcatc tacagcagtg gtggcatcac agtgtatgct gactctgtga agggcagatt     1140

caccatcagc agagacaaca gcaagaacac cctgtacctg cagatgaact ccctgagagc     1200

tgaggacaca gcagtgtact actgtgccta tagaagaatt ggggtgccca gaagggatga     1260

gtttgacatc tggggccagg gcaccatggt tacagtgtcc tctgccagca caaagggccc     1320

ctctgttttt ccactggctc ccagcagcaa gagcaccagt ggtggaacag ctgccctggg     1380

ctgtctggtc aaggattact tccctgagcc tgtgactgtg tcctggaact ctggggctct     1440

gacttctggg gtgcacacct ttccagctgt gctgcagtcc tctggcctgt actctctgtc     1500

ctctgtggtc acagtgccta gctctagcct gggcacacag acctacatct gcaatgtgaa     1560

ccacaagcct agcaacacca aggtggacaa gagagtggaa cccaagagct gtgacaagac     1620

ccacacctgt cctccatgtc ctgctccaga actgcttgga ggcccttctg tgttcctgtt     1680

tcctccaaag cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt     1740

ggttgatgtg tcccatgagg acccagaagt gaagttcaat tggtatgtgg atggggttga     1800

agtgcacaat gccaagacca agcctagaga ggaacagtac aacagcacct acagagtggt     1860

ttctgtgctg acagtgctgc accaggactg gctgaatggc aaagagtaca agtgcaaggt     1920

gtccaacaag gccctgcctg ctcctattga gaaaaccatc tccaaggcca agggccagcc     1980

aagagaaccc caggtttaca ccctgccacc tagcagagaa gagatgacca agaaccaggt     2040

gtccctgacc tgcctggtta agggcttcta cccctctgac attgctgtgg aatgggagag     2100

caatggccag cctgaaaaca actacaagac aacccctcct gtgctggact ctgatggctc     2160

attcttcctg tacagcaagc tgactgtgga caagtccaga tggcagcagg gaaatgtgtt     2220

cagctgctct gtgatgcatg aggccctgca caaccactac acccagaaaa gtctgtctct     2280

gtcccctggc agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg     2340

ggatgttgaa gagaatcctg ggcctatgta taggatgcaa ctgctcctcc tgattgctct     2400

gagcctggct cttgtgacca actctgacat ccagatgaca cagagcccct ccacactgtc     2460

tgcatctgtg ggagacagag tgaccatcac ctgtagagcc agccagtcta tctctagctg     2520

gctggcctgg tatcagcaaa agcctggcaa ggcccctaag ctgctgatct acaaggccag     2580

cacacttgag tcaggggtgc cctccagatt ttctggctct ggatctggca cagagttcac     2640

cctgaccatc agctccctgc agccagatga ctttgccacc tactactgcc agcagtacaa     2700

tacctactgg acctttggcc agggaacaaa ggtggaaatc aagagaacag tggctgcccc     2760

atctgtgttc atcttcccac catctgatga acagctgaag tctggcactg cctctgttgt     2820

gtgcctgctg aacaactttt accccagaga agccaaggtg cagtggaaag tggataatgc     2880

cctgcagtct ggcaatagcc aagaatctgt gacagagcag gactccaagg attccaccta     2940

cagcctgagc agcaccctga cactgagcaa ggctgactat gagaagcaca aagtgtatgc     3000

ctgtgaagtg acacaccagg gactgagcag cccagtgacc aagagcttca acaggggaga     3060

gtgctgataa ctcgaggacg gggtgaacta cgcctgagga tccgatcttt ttccctctgc     3120

caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa     3180

atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca                    3226


<210>  156
<211>  3472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  156
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     1020

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1080

atccactttg cctttctctc cacaggttga attcgccgcc accatgtaca gaatgcagct     1140

gctgctgctc attgccctgt ctctggccct ggtcaccaat tctgaggtcc agctgcttga     1200

gagtggtggt ggactggttc agcctggtgg cagcctgaga ctgtcttgtg ctgcctctgg     1260

cttcaccttc agccactata tcatgatgtg ggtcagacag gcccctggca aaggcctgga     1320

atgggtgtca ggcatctaca gcagtggtgg catcacagtg tatgctgact ctgtgaaggg     1380

cagattcacc atcagcagag acaacagcaa gaacaccctg tacctgcaga tgaactccct     1440

gagagctgag gacacagcag tgtactactg tgcctataga agaattgggg tgcccagaag     1500

ggatgagttt gacatctggg gccagggcac catggttaca gtgtcctctg ccagcacaaa     1560

gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg gaacagctgc     1620

cctgggctgt ctggtcaagg attacttccc tgagcctgtg actgtgtcct ggaactctgg     1680

ggctctgact tctggggtgc acacctttcc agctgtgctg cagtcctctg gcctgtactc     1740

tctgtcctct gtggtcacag tgcctagctc tagcctgggc acacagacct acatctgcaa     1800

tgtgaaccac aagcctagca acaccaaggt ggacaagaga gtggaaccca agagctgtga     1860

caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc cttctgtgtt     1920

cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg     1980

tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg     2040

ggttgaagtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag     2100

agtggtttct gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg     2160

caaggtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca aggccaaggg     2220

ccagccaaga gaaccccagg tttacaccct gccacctagc agagaagaga tgaccaagaa     2280

ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg     2340

ggagagcaat ggccagcctg aaaacaacta caagacaacc cctcctgtgc tggactctga     2400

tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc agcagggaaa     2460

tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaaaagtct     2520

gtctctgtcc cctggcagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac     2580

atgtggggat gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat     2640

tgctctgagc ctggctcttg tgaccaactc tgacatccag atgacacaga gcccctccac     2700

actgtctgca tctgtgggag acagagtgac catcacctgt agagccagcc agtctatctc     2760

tagctggctg gcctggtatc agcaaaagcc tggcaaggcc cctaagctgc tgatctacaa     2820

ggccagcaca cttgagtcag gggtgccctc cagattttct ggctctggat ctggcacaga     2880

gttcaccctg accatcagct ccctgcagcc agatgacttt gccacctact actgccagca     2940

gtacaatacc tactggacct ttggccaggg aacaaaggtg gaaatcaaga gaacagtggc     3000

tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagtctg gcactgcctc     3060

tgttgtgtgc ctgctgaaca acttttaccc cagagaagcc aaggtgcagt ggaaagtgga     3120

taatgccctg cagtctggca atagccaaga atctgtgaca gagcaggact ccaaggattc     3180

cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga agcacaaagt     3240

gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga gcttcaacag     3300

gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg atctttttcc     3360

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     3420

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct ca             3472


<210>  157
<211>  3553
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  157
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt caggtaagta tcaaggttac aagacaggtt     1080

taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag     1140

gcacctattg gtcttactga catccacttt gcctttctct ccacaggttg aattcgccgc     1200

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1260

ttctgaggtc cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag     1320

actgtcttgt gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca     1380

ggcccctggc aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt     1440

gtatgctgac tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct     1500

gtacctgcag atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag     1560

aagaattggg gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac     1620

agtgtcctct gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag     1680

caccagtggt ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt     1740

gactgtgtcc tggaactctg gggctctgac ttctggggtg cacacctttc cagctgtgct     1800

gcagtcctct ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg     1860

cacacagacc tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagag     1920

agtggaaccc aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact     1980

gcttggaggc ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag     2040

cagaacccct gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa     2100

gttcaattgg tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga     2160

acagtacaac agcacctaca gagtggtttc tgtgctgaca gtgctgcacc aggactggct     2220

gaatggcaaa gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa     2280

aaccatctcc aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag     2340

cagagaagag atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc     2400

ctctgacatt gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac     2460

ccctcctgtg ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa     2520

gtccagatgg cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa     2580

ccactacacc cagaaaagtc tgtctctgtc ccctggcaga aagagaagag gctctggaga     2640

aggcagaggc tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag     2700

gatgcaactg ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgacatcca     2760

gatgacacag agcccctcca cactgtctgc atctgtggga gacagagtga ccatcacctg     2820

tagagccagc cagtctatct ctagctggct ggcctggtat cagcaaaagc ctggcaaggc     2880

ccctaagctg ctgatctaca aggccagcac acttgagtca ggggtgccct ccagattttc     2940

tggctctgga tctggcacag agttcaccct gaccatcagc tccctgcagc cagatgactt     3000

tgccacctac tactgccagc agtacaatac ctactggacc tttggccagg gaacaaaggt     3060

ggaaatcaag agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgaaca     3120

gctgaagtct ggcactgcct ctgttgtgtg cctgctgaac aacttttacc ccagagaagc     3180

caaggtgcag tggaaagtgg ataatgccct gcagtctggc aatagccaag aatctgtgac     3240

agagcaggac tccaaggatt ccacctacag cctgagcagc accctgacac tgagcaaggc     3300

tgactatgag aagcacaaag tgtatgcctg tgaagtgaca caccagggac tgagcagccc     3360

agtgaccaag agcttcaaca ggggagagtg ctgataactc gaggacgggg tgaactacgc     3420

ctgaggatcc gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     3480

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     3540

tttgtgtctc tca                                                        3553


<210>  158
<211>  3592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  158
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     1140

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1200

atccactttg cctttctctc cacaggttga attcgccgcc accatgtaca gaatgcagct     1260

gctgctgctc attgccctgt ctctggccct ggtcaccaat tctgaggtcc agctgcttga     1320

gagtggtggt ggactggttc agcctggtgg cagcctgaga ctgtcttgtg ctgcctctgg     1380

cttcaccttc agccactata tcatgatgtg ggtcagacag gcccctggca aaggcctgga     1440

atgggtgtca ggcatctaca gcagtggtgg catcacagtg tatgctgact ctgtgaaggg     1500

cagattcacc atcagcagag acaacagcaa gaacaccctg tacctgcaga tgaactccct     1560

gagagctgag gacacagcag tgtactactg tgcctataga agaattgggg tgcccagaag     1620

ggatgagttt gacatctggg gccagggcac catggttaca gtgtcctctg ccagcacaaa     1680

gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg gaacagctgc     1740

cctgggctgt ctggtcaagg attacttccc tgagcctgtg actgtgtcct ggaactctgg     1800

ggctctgact tctggggtgc acacctttcc agctgtgctg cagtcctctg gcctgtactc     1860

tctgtcctct gtggtcacag tgcctagctc tagcctgggc acacagacct acatctgcaa     1920

tgtgaaccac aagcctagca acaccaaggt ggacaagaga gtggaaccca agagctgtga     1980

caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc cttctgtgtt     2040

cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg     2100

tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg     2160

ggttgaagtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag     2220

agtggtttct gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg     2280

caaggtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca aggccaaggg     2340

ccagccaaga gaaccccagg tttacaccct gccacctagc agagaagaga tgaccaagaa     2400

ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg     2460

ggagagcaat ggccagcctg aaaacaacta caagacaacc cctcctgtgc tggactctga     2520

tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc agcagggaaa     2580

tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaaaagtct     2640

gtctctgtcc cctggcagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac     2700

atgtggggat gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat     2760

tgctctgagc ctggctcttg tgaccaactc tgacatccag atgacacaga gcccctccac     2820

actgtctgca tctgtgggag acagagtgac catcacctgt agagccagcc agtctatctc     2880

tagctggctg gcctggtatc agcaaaagcc tggcaaggcc cctaagctgc tgatctacaa     2940

ggccagcaca cttgagtcag gggtgccctc cagattttct ggctctggat ctggcacaga     3000

gttcaccctg accatcagct ccctgcagcc agatgacttt gccacctact actgccagca     3060

gtacaatacc tactggacct ttggccaggg aacaaaggtg gaaatcaaga gaacagtggc     3120

tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagtctg gcactgcctc     3180

tgttgtgtgc ctgctgaaca acttttaccc cagagaagcc aaggtgcagt ggaaagtgga     3240

taatgccctg cagtctggca atagccaaga atctgtgaca gagcaggact ccaaggattc     3300

cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga agcacaaagt     3360

gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga gcttcaacag     3420

gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg atctttttcc     3480

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     3540

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct ca             3592


<210>  159
<211>  4083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  159
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca     1620

atagaaactg ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg     1680

tcttactgac atccactttg cctttctctc cacaggttcg aattcgccgc caccatgtac     1740

agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa ttctgaggtc     1800

cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag actgtcttgt     1860

gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca ggcccctggc     1920

aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt gtatgctgac     1980

tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct gtacctgcag     2040

atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag aagaattggg     2100

gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac agtgtcctct     2160

gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt     2220

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gactgtgtcc     2280

tggaactctg gggctctgac ttctggggtg cacacctttc cagctgtgct gcagtcctct     2340

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacacagacc     2400

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagag agtggaaccc     2460

aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact gcttggaggc     2520

ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct     2580

gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa gttcaattgg     2640

tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga acagtacaac     2700

agcacctaca gagtggtttc tgtgctgaca gtgctgcacc aggactggct gaatggcaaa     2760

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa aaccatctcc     2820

aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag cagagaagag     2880

atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc ctctgacatt     2940

gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac ccctcctgtg     3000

ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa gtccagatgg     3060

cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa ccactacacc     3120

cagaaaagtc tgtctctgtc ccctggcaga aagagaagag gctctggaga aggcagaggc     3180

tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag gatgcaactg     3240

ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgacatcca gatgacacag     3300

agcccctcca cactgtctgc atctgtggga gacagagtga ccatcacctg tagagccagc     3360

cagtctatct ctagctggct ggcctggtat cagcaaaagc ctggcaaggc ccctaagctg     3420

ctgatctaca aggccagcac acttgagtca ggggtgccct ccagattttc tggctctgga     3480

tctggcacag agttcaccct gaccatcagc tccctgcagc cagatgactt tgccacctac     3540

tactgccagc agtacaatac ctactggacc tttggccagg gaacaaaggt ggaaatcaag     3600

agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgaaca gctgaagtct     3660

ggcactgcct ctgttgtgtg cctgctgaac aacttttacc ccagagaagc caaggtgcag     3720

tggaaagtgg ataatgccct gcagtctggc aatagccaag aatctgtgac agagcaggac     3780

tccaaggatt ccacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag     3840

aagcacaaag tgtatgcctg tgaagtgaca caccagggac tgagcagccc agtgaccaag     3900

agcttcaaca ggggagagtg ctgataactc gaggacgggg tgaactacgc ctgaggatcc     3960

gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact     4020

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc     4080

tca                                                                   4083


<210>  160
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  160
ggtacaatga ctcctttcg                                                    19


<210>  161
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  161
ggtacagtga ctcctttcg                                                    19


<210>  162
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  162
tcattctacc                                                              10


<210>  163
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  163
ggatataccc tcctatgctc ctcttttcat tctcaaagcc accctgttcc tggaatgtga       60

gatctcctaa ttgttgactg gagaatcaaa tgctaccttt gcaacagctt atcggaagca      120

aacaagctga ggggaattga gcaagaattt ctgggatacc aacagcatag gaggaacaaa      180

ggacgtagag ggagggttga ctgtctacac aggacaaagc caatgattaa ccaaacctct      240

tgcagattta aataggatgg gaactaggag tggcagcaat cctttctttc agctggagtg      300

ctcctcagga gccagcccca cccttagaaa agatgttttc catgaggat                  349


<210>  164
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  164
ggtagacagg aaaaaaggca aaggctacca tctgctatta ctgatgatat tactgaggaa       60

ttgatacatt tctatctata gagatttatt aatgtacaac tggttctaca actttatttg      120

ttcagtctac ataaccaaaa tgaggcttca agtccggaag ttccctgtta cccaaggcaa      180

acgtattagg gtctgttctg ccatctggtg ttctttgaag gaaacatcca cagaggcatt      240

atgagataaa tagccagtgt tgcctatgtt ggtggtgggt gttacaacct cgatgaaaag      300

caattccaga atctctgcca aattccaata ggagataatt tgagaatat                  349


<210>  165
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  165
caaccccgga aacaacaagt ttctgtcaaa agcaataatg aactgttttg tgccattaac       60

aaaaacgtta tgaagacaga aaccatctcc caaagatttc ataacagagc cacataagtg      120

gaaagtaaat gattaaagaa tgtgggtctc agagttccat tcaaatcatg atactttatc      180

ttctatttac aaagataaaa gtacaccaga aaatggttaa tgtttaagcg ctttcatatt      240

tggctctgtc tttttagcag acgaaaacca ctttggtagt gccagtgtga ctcatccaca      300

atgatttctc cagtgctcat cttgttctcg agttttctct gccatgttg                  349


<210>  166
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  166
aagccctgtg acatgtttat accccttata aatgcatatc tagttcctga catattttat       60

cataaagaga aggcatttga atcttttctc tgaaatgtgg ttggtagata ttgactagaa      120

ttccaactca gaaggagaca acattgaaag taggttttta aacaaataat ctaaactgtt      180

gctaaatgtt taatatcatg gtcaaagtct ctgcttggga agtaaataag aaagtttttg      240

aacatgtgat gcaatgtggt ttcaggaata caaaaacctt ggactctgaa tccaggtctc      300

tatagtttaa tttacaaatt agcgtaaga                                        329


<210>  167
<211>  237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  167
agtgcatagt tttccaattg aagtataatc aagtaaacac acagatctta aatatttggc       60

ttgatggctt ttgaaaattg catgtagcca agtaacaacc acctaaaata gaatataaac      120

tatttcgaca cccctacccc aagtttccta atgcaaggga gcccagccac caggaaacat      180

cattaaaaac ccttctcctt gtcctctctc aatatcaggc actcagtttg tagctgt         237


<210>  168
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  168
agcccacaaa agccgtcaaa ctaagtttga tttagtggtt tctccatttt cctgtcactg       60

ttattttgca taatttttca aagctcagta gctggcaaat aggagctgag tgtcaatgat      120

ggcggtgggg tgggggccaa gcttgtattc ctctttaggg ggcgatgcaa ataaaatttg      180

aggcctcgta tgatccagtt taaaaatcac atctcaatag aaggactttc aaggaaacca      240

caaaaagcgt ccttccttcc t                                                261


<210>  169
<211>  301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  169
agacccttcc attcaagtgt caccaaatgc cccttcgggc ccacactgtg cacccagttc       60

tcatgtccac ctgggttccc taagtctttc tttgcctttc atggcttttg cccttttgaa      120

gatgacaggg cagtcatttt gcataacgtc cttcaatttg tgtgtgtaca gtgccttctc      180

atgacacaat ccaggttact aagcttttgg caggaatatc acagaagtga cgctgtgtcc      240

ttctcattgc atcctcttgg tggaggacat acatgccaat ttatcccatt agtggtgaca      300

t                                                                      301


<210>  170
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  170
ggggctcatc catgtaagtc tcatctgcaa tcactgggct gatcccgtgg ccctgtctcc       60

agggcgccat cagagagggc ttcaatcctc aggttacctg tggcccaccc tgccctcaga      120

ggtgccatct ctacattggc cacgagatgg cagcacatac tcatagactg cattaatttc      180

ccagcaactc ctggtgggtt ttccctctta tcaggatgtt tgccttgctc agagagcaaa      240

tctgagagca gtgacaccta acttaacttt cagcaaaata ttttgagaag ggtgcccctt      300

tacacatctg tgcagtccag gtgatgcat                                        329


<210>  171
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  171
tctgggtgcc cactccaggg cctggcttgg ctgccaactc cagtcaggga ctttcagcca       60

cccctccccc caggttattt caggagcacc tgcctgggcc tgggatggct tctctggtga      120

aagaaacacc aggattgcat cagggaggag gaggctggga tgtccagggt ctgagcatct      180

gagcagggac agatgaggtt gaggttggcc cacggccagg tgagaggctt ccaaggcagg      240

atacttgtgt ctc                                                         253


<210>  172
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  172
gagatcctca caccttggcc ttccaaagca ctgggattac aggcgtgagc cactgtgctc       60

cctccgccta gactgtgatc ggcctaaatc tgatggtttc tttaagacca gtttttacag      120

agaaggcagc gggcttgcat tcttctgtgc cactggcaag gactgccacc agagggcgct      180

ctaccatccc ttctggtgct ccctgggccc tgatcttgct ttccactcat gccgcaaaaa      240

gccagctact cttcaagatt aaactctcca gggctttctt ttatagatag gatgagaagc      300

aaagaacttc tttgatttta cagcctggat cttttcagtt ttggttgtat                 350


<210>  173
<211>  283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  173
ccttctcttc aagttggttg ccccggtgac ctttcgccac caccgctatg atgatcttgt       60

gcggacgctg tacaaggtgc aaaacgaatg ccccggcatc acgcgggtct acagcattgg      120

gcgcagcgtg gaggggagac acctctacgt gctggagttc agcgaccacc ctggaatcca      180

cgagccctgt aagttctgaa cagctcttga gggtgtgtgg ggcagggcct ttcccttgca      240

aatccagtaa ttggagtggt ttctggggtg gtccgtggac gcc                        283


<210>  174
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  174
ctaggattac aggtatgagc caccatgcct ggcctctttt ctctcttaag gtcaccctgg       60

catgtagtct ggcctgactc tgcctgtgta aacacaaagg agcaagggtc aagtgcacca      120

tgtaatctgc ccacatactc tcaggatgac cctggtcttt gtaaactttg ctttgagaac      180

cagtgatatg agcatcactt acagagggac tgtgtgggag gggggaacag tgctctttgg      240

gagagtcaat caggccagtg cagtgggttc aggcttcaag aaaga                      285


<210>  175
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  175
caccttatgc caaagtctgt tctatcctgg accacattct gtggtagtgt ttgtttaact       60

tttcaatttc tctttcaacc ctgactagtc tgtaagttac ttaagggtag tgactgtatc      120

ttcctcatgt ttttaccccc atagagccca gcatataata ctagctcaac acatgtttgc      180

ccgatcaagt caccaataaa caaaagaatg agccagcttc ctcccggttc cttggcaagt      240

gtgaataact aagtcatttg tagttgacac tcagctcaga ggctgagggt tctaaatgta      300

tgtcccccaa agggattcat cttatgcact tcattaccag tcaagctatc                 350


<210>  176
<211>  193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  176
tttcttcacg tgaattcaga ttctactgaa ttcagctctg caccaagtcc catcctctgc       60

tgccctctgt ttcagcaaac actgaggcct gttgtttctc ctcctctacc ggctctgatg      120

cggtcaaggt ccagagagct gagtagttgg caagcggacc accagcaaca gacaacatct      180

tcattcggct ctc                                                         193


<210>  177
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  177
gccagaaggg ccaaggggag gatggggcgg acccgggcag gggtcctggc tggaggggag       60

cagaagagga gctctgggat taaccccggt gggtgccact tagggccaga gcctctccca      120

ggtgggacct gcgtctcatg gtggctgcgc ggccatcgct ggggccaagg cgccgcctgg      180

tggtgaggcc gggccctgca gccacacagg cgtgccccag gcaggggaca ggtgggcagg      240

gtctgtgggg tgcggtgcca gccgccctgc tcacatgggt cctgggacac atgggagggg      300

tctgctgcct gacagtgtgg gtgtcaggct tccaggaagc cacgtg                     346


<210>  178
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  178
actaggacca gtgcaggccg aggccagaga gacagctggg cttccaggta gggtcaaagt       60

gaggtgggca gcaggtgtgg gggccagggg actcggggac ttcctctccg gctgggcccg      120

cctgacgtgg gaggcagcca gggttaatca tttccacgaa gccttgaccc cacctgcctt      180

ggccgctctg ctcccgcctc ccactgcccc tcaggccagc tcaggagcca tggggcgctg      240

ggcctgggtc cccagcccct ggcccccacc ggggctgggc cccttcctcc tcctcctcct      300

gctgctgctg ctgc                                                        314


<210>  179
<211>  202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  179
aaactgacgt cagggtttaa gcttggtggg tagcagtgcc tgggcctggg cagtgaccct       60

gagcaggtgt taactagggg ccgagggcgg ggaaggtgtc agggcctggc tgaggcctca      120

ggaatgtcgt gtgtcctcct ggaacctgct ccgagatctg ggggccccag tatggaaaca      180

ggctcagggc tgtgacctcc tg                                               202


<210>  180
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  180
cctccccaca gcactcaccg aggacgggag gccctgcagg ttccccttcc gctacggggg       60

ccgcatgctg catgcctgca cttcggaggg cagtgcacac aggaagtggt gggtccgggc      120

agccggggca cccgagctgg ggtcacctgc cccacgctgc ctgcttttct gggagccggg      180

cacacagtag gcgctca                                                     197


<210>  181
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  181
gccaccctga aaggaaggac acaaggttgg ctggtttcac cacctcctga ttgtagaacc       60

ctaggacctt tagcaaatat aggtggtaac aaggaaatgc ttaccttggg ccttggccaa      120

gacccagtgc tatgctgtct tcaggtctga cccaggacag tcctagtggt agtggcctca      180

gggagttttt gt                                                          192


<210>  182
<211>  184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  182
tgggagccca ctgccctaaa gggtgagtcc caggtctgga agcattcacc acaagctgac       60

caaacagccc ttggaccata agttaataat caccctggaa gtattccaca tgggcctgtg      120

gcggtattgg acacacagac agattcctct tctggtggaa aggggagaga agagtggaaa      180

ggat                                                                   184


<210>  183
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  183
ttccagccgg ctccgctccg ggtcccccag tgctcgctgg ctccccgctt gagccagccc       60

gcccgcccag cgctaggggc caaggagcga accgcacctg cgatccgatt gtccggggca      120

cgccgtagag gatgggagga cccatgaggc gctagcctgc gaaggtggcg gtgctgctgc      180

tccggctgct cttggagttg catgtacacg acgtggcaga ctttccaatg ggaggattgt      240

ggattctgat gacataggaa acttcatctt ccagacattg ccacagaaag cacacagact      300

ttggaaacca gcagacctga agtcaaatgt cgactttcag cttgctcctg                 350


<210>  184
<211>  338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  184
ctcgcgagcc cgcgtgagtg cccaggggaa ggggtgtagg cgaagggagg agacagctgg       60

gccatgccat gatgacctgc ctctgctgcc tcaacctctg tggccgctgc tgggacagag      120

gaaaggagcg gtgctagctc tgtctgcaga tcccggccat cctgggctct ttagcgccct      180

ctgcctgcag cccccgcctt gacaactccg tagctgttgc ccccttgctc actgaggcgc      240

gggacctggg atcaatcggg aggacgcccg ctgcagtccc cagaatcaaa ggatgatgtg      300

gcgcatctat gtttctttgg agagtgttgt aggtctgg                              338


<210>  185
<211>  344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  185
acacagtgac tctgggtagt tgtgtaagag aggggccctt ggcagacaaa caggttcttc       60

tctgttggtg ggccagccag caggtcagtg ggaaggttaa aggtcatggg gtttgggaga      120

aactgggtga ggagttcagc cccatccccc gtaaagctcc tgggaagcac ttctctactg      180

gggcagcccc tgataccagg gcactcatta accctctggg tgccagggaa agggcaggag      240

gtgagtgctg ggaggcagct gaggtcaact tcttttgaac ttccacgtgg tatttactca      300

gagcaattgg tgccagaggc tcagggccct ggagtataaa gcag                       344


<210>  186
<211>  338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  186
ggttatagga ggagctgggg agtatgggaa gcctcccact tggtctttgg ttttccagaa       60

actccaccat cacaagcagg atgttaatca gtaaccgtcc cacaggggat catactttgg      120

aatagcaaat atttgctgaa ggttctgggc tgcaaagctg aagctttggt ttctgctcta      180

aatgaaggac ttttccagga cccaaggcca cacactggta agaggcagtg ggttacagga      240

gaccttcaat gagtctaatc agggagggac cgggaaggat ggtatcatcc ctgggcgggc      300

tccaacgtga gggctgtgtg gctgagcagt gcaaagac                              338


<210>  187
<211>  184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  187
ccagggctga gaagtggcag gtgagctggt gattccttac tgcccaggtt ctgtctagga       60

aggtgcgtcc tcaccatgct ggatggtgtc ctagtccagg agcaccccct gagctcctgg      120

cctagactcc aaagggttgg gtagatgagc aaagacttta caaagacctt aggcgatata      180

tgtc                                                                   184


<210>  188
<211>  292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  188
tgatgccacg taatcgtttt agctcaggct cctctaacaa aacaccacag gctgggtggc       60

tccaacagcc attgattttt cacagttttg gaggctgaaa gtccgagtca gggtgccagc      120

gtggccggat tctggtaggg ctgtcttctt ggcttgcaga tggccacctt cgcaccgtgt      180

cctcccatgg agaggaggtg cggaggggga ctctgctctc ttcttatgac agcactagtg      240

ctatcacagg ggccttgccc tcacgacctc atctaaacct aatcacctcc ca              292


<210>  189
<211>  256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  189
tctgctctcc caaggccaca gggccctacg attgtctctc cctttccttt cgttaggcca       60

gcatatgatt aacgctacgt gattttctat gaatgtgttt tcacgtttca aaaacagatt      120

gatacacata ttgaacagtg ccagacgctg tcatttgagg cccttccctg gtatcctatg      180

tgcttgtagt ccttattatt ttcagagcac tctacatagc tcccctctga cacttagaag      240

catagggtct ttccaa                                                      256


<210>  190
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  190
ggtgtgaatg agacaaagtg gcagtcagag gtgccaggca aaggcttttc tctaagctgg       60

agccaactat gagggaacga ctgtgaattc cgttcaggtc caggacaatg agaggagcca      120

gggattgtta ggaaacattt ccctgctttc gtgtgcgatt cccaataggg cctgcgagtg      180

gagctgcatt ttgctagctg ggctagagga cggggaaaat tttggggaaa tttattttgc      240

ctgcctgagc tgtggaaaag ccaacccaat tagggaacgc ctttcctagt tggaacgaga      300

agacgagaag tgagagaagt gagatagaag gctccctctc                            340


<210>  191
<211>  227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  191
gaagttttct ttccgaagtt caagctagat cagaagtatg agatgcatga gctgcttagg       60

cagatgggaa tcagaagaat cttctcaccc tttgctgacc ttagtgaact ctcagctact      120

ggaagaaatc tccaagtatc cagggtaagt caggatcttt catcagagcc caacctcagc      180

atgaaatgtc accaaaacaa atgcttttac aaaccattta actttga                    227


<210>  192
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  192
gccactttcg cagagctggc accagactta caaagccccg gcaggggaag ccactttaca       60

accagccagg ccacaccccc agggcagacg tttatgtaga gagtaatgta cctgcctgct      120

agtagcctct gcattgtggg gccttctctc agaaccacac taaacagtgg gtgggtgaga      180

agtgtcactc ctgccacctt                                                  200


<210>  193
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  193
gacagggaca tttatgtcta cagaagtttc tgctgccttt tgttcagcta tgccctgccc       60

ccagaggtgg agtttacaga agcagcaggc cttgctgagc tgcagtggtc tctgcccagt      120

tcaagctttt ccagctgctt tgtttaccta ctcaagcctc agcattggcg gacgcccctc      180

cccctgccag gctgctgcct cacaggtcga tctcagactg ccacactagc agtgagcaag      240

gctctgtggg cgtggtaact gccaagccag gcacaggata cagtctcctg gtgtgtcctg      300

gagactggac acaccactaa gaccactgga aaagtgcagt atttgtgtgt g               351


<210>  194
<211>  182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  194
atttgaaggg gtatcacaat attcatctat tttctggaaa tattttccaa catgcaatta       60

gcaggaaaat tgaatgaaat taattctctc cgttctctag tttgctaagg gtaaatggtc      120

accaaataga taatgtaaag agaaatcaaa ggagagaaaa tctgctataa taaagatgac      180

aa                                                                     182


<210>  195
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  195
gcccagggac gtgtctttcc ctaaacaaac caacctctcc tcacatcccc cactctgtac       60

tttcactgac tatgcgttgg cagattctgc caagttctac ctgtaactgg cttcattttc      120

aagtcagacg tttggctgct gctctgtccc ctgcaacaag gagccatgcc agctggacac      180

acacttcttc cagggcctct ggcagccagg acagagttga gaccacagct gttgagaccc      240

tgagccctga gtctgtattg ctcaagaagg gccttcccca gcaatgacct cctcattgct      300

tctggccttt ctcctcctgg ctccaaccac agtggccact cccagag                    347


<210>  196
<211>  344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  196
tcccgacaac ccccacatcc ctctggggtc actctggtag ctcagacctg accaataggc       60

agctggaaag ctggtaaatt tcacttcttt tgagattggc tgccgtcatc tcctccggct      120

cctctctctg caggccccac aaacccacag gctgtggtgt gagcccatcc acttcctggg      180

cctgtacaca gcgactggga ggtgggagtc tctcctttct ctggccccag gatctagccc      240

ctcccttccc ctctcctcca gatgcctcat ttgagtaaaa gaagaaaaaa taaaacacca      300

ggactgcaat acctcaccat atgtcatgtt cccatatata cctc                       344


<210>  197
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  197
ataatattgc cttatagcct caaactcctg gcctcaaggg atcctcctgc ttcagcgtcc       60

tgagtagctg gggctatagg catgtgttcc catgaccagc taacaaaagg ttttatagct      120

gaccctttat ttgttttgat cttcactctg agtccctgta ttactggaaa tgccctggat      180

ttgatttttg ccctgaggta atttcttact ttaagaacct tttgtcagag agaaagaatg      240

aaaaagaatt tttgtcatta tttttctttt ctttcctcta catgtacaac atgaagtaaa      300

aggttttgtt ttgttttgtt                                                  320


<210>  198
<211>  341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  198
tgagctctat cacctgagct cccctgccct ctggcttcct gctgaggtca gggcatttct       60

tatccctgtt ccctctctgt ctaggtgtca tggttctgtg taactgtggc tattctgtgt      120

ccctacacta cctggctacc cccttccatg gccccagctc tgcctacatt ctgatataac      180

tgcttcaaca ctagggggtc ctaaaggctt tctatcttgc tagtccctgg ggcctcaaca      240

tctcatactg gttcccttaa ctctgcctat acctctgtaa ataattcctt cactaagttc      300

tcttgatgaa gcaaaaacag acagctgaaa agtcctctat c                          341


<210>  199
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  199
atttgtagtc ttatagaaat tgacaaagac tacaaatcag ggcttttgat ttttttccct       60

ggagaccagt tattaaacat ttaccagcat accactgtct gcgtcctaaa aatacaagtt      120

ctctacctcc cacgcactta acatacaatg ctgagacagg gacaggataa acataataga      180

tattcctgtt caaaatgggg tatgggagaa taggagacac agagcagtca ctgatccata      240

aaacttctta tattcagcca ggcaaatatc taggtccact ccaaacccag aattcccttg      300

gttagttagg gcctggttct gctccctggt atttcccat                             339


<210>  200
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  200
catcctgggt ggagctgccc ataggccttt tgtggcagcc cgggtgagag ttgggggcaa       60

acaccagatt caccgacgag gcatcgactg ccaaggaggg tccaggatgt gctgtcgaca      120

agagtttttt gtggacttcc gtgagattgg ctggcacgac tggatcatcc agcctgaggg      180

ctacgccatg aacttctgc                                                   199


<210>  201
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  201
agaaacagtg actggaaaag aattatcaca ttgcacaagg atggctctga aatggactac       60

agttctgctg atacaactca gtttttactt tagctctggg agttgtggaa aggtgctggt      120

atgggccgca gaatacagcc tttggatgaa tatgaagaca atcctgaaag aacttgttca      180

gagaggtcat gaggtgactg tactggcatc                                       210


<210>  202
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  202
tcttcttttc tttattccta tcaggaagac ccactacatt atctgagaca atgaggaaag       60

ctgacatatg gcttatgcga aactcctgga attttaaatt tcctcatcca ttcttaccaa      120

atgttgattt tgttggagga ctccactgca aacctgccaa acccctacct aaggtaaaca      180

tactttcgtt ggttttattt tgttggcttc aaatttcagt agaaatgact gtatagtctt      240

cattcagagt gtttgactaa cactgaaaaa gatgggaagt aggtggggta aagcagatac      300

caattagaaa ctcatgtaca tgttaatacc atcaca                                336


<210>  203
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  203
aaaaatacga gactgattat ggtcgagtac agatctctat ttcaataatt tctcaaaaat       60

ttctagctat aatttacaaa tatttttact taatattatt aagatcttag cttggatcca      120

aatgagtagt tggtacaatg atttcagcca tactcacaaa atagtccaca gttaacttga      180

agaaccaaag ataaaaggat tagcttaatg agttgtgtaa actagactat ttgttagaaa      240

attgtttcta tggttactgt agaattaatt gattatggag ctcaaagatt tgtttaaata      300

tctagaggct actattgaag ctttaaagag aaaataa                               337


<210>  204
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  204
ctcacattca gtacttcttt agatcctcat aagaaatctg ggaattaagt attattccca       60

ttttctagat aatgaggatc agacttagac aggggcagtt aggccacata gctagaaagt      120

gagtcacatt tacttagttt taccatgtga caggtctttc ccctatatca tctcccttaa      180

tcctcacaat aatcctggag ggtgtgatga ctgttctccc tttacagatg aggaaggagg      240

ctccgtgtgt catgtgccaa agatcacaca gtcggaagca gggtagctgg ggtttgaagc      300

caggttttcc ggctccagat tcaatcctcc ttgtgcttca tctactac                   348


<210>  205
<211>  299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  205
tcaaatctct ttaaaaatat aaaagtcatt cctggctcaa aggccataca aaaataagct       60

gtgggttgga cttggaccca ggctgcaatt tgctaccatc ctccacagtt atctcatctc      120

tccattagag gaacctctgt catagatact attccctccc attaaaaaga ttaggaaaca      180

ggctctgaaa aatcaagtga aaatatttga ggtcatatag ctcagaggtg gcaatgcttg      240

gatttcagac ctttggactt cgtatccagt tctcacttct ctctatccta gcacctcca       299


<210>  206
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  206
cttccagtaa gtggttttct ccccttggct ggggacccta ccagtcctga tattacctgc       60

ctgctgacct caaccgcaac ccctgaccac aggccaaagt ctgtttgcca caggtctttc      120

tgtacacatt tccaggaact cagacaaagc tattgccagt gccctcagtt gacttctgtt      180

tccagggaag tgcgactacc gtaatgtggc tcagtcctac tgctgacttg ctctggcaca      240

gtcctactgc tgacttgctc tgtgaccttg gcaaatcact tcccctttgg gggcctcagg      300

ttcctctcct taaaatgaga gatctggaga agtgccttcc tttta                      345


<210>  207
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  207
ccacccacag tggggcaagg aggtgttact ggcatccagg aggcagaggc ctgggatgct       60

gctaaacatc cttccatgca cagaacagac cccacagcaa agaaatatct ggcctcaagt      120

gtcaatactg ccaaaattga gaaaccctgc cttaaatgct taacctcaca aagtgtgaaa      180

aattctattt taaccacaaa ggaagtgatt gttctagcag ttgccaaact atttctgtcc      240

atatgtggtg tagtccattt aagagactgc atttcagact ttgaagcaaa agatcatcat      300

tttctcatcc attttctccc caccc                                            325


<210>  208
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  208
tcgaggcaat tgtttccccc aaggaatatt tggcaatgtc aggagacagt cttggttttc       60

acaactggaa gggggctgct ggcatgtagt gggtagaggc cagagactct gctaaacagc      120

ctacaataca aggacagccc actcctgcca gtaaagaatt atccaacttg atacgcaata      180

gtgccgaagt tgaaaaaccc tgaactacgg tcatgtctgg aatgggttgc atcagttgta      240

aataactccc acccagccac atgtagctgc cacagttaca ccattaggga aattgctcag      300

caatgacaac aacactacct gtcaaggatt ttattaattc                            340


<210>  209
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  209
cacagatgcc ttccctgacc ctgctgccct gtgtcagagt cctcctcgca cactacaata       60

attatctgtt tccttgtcca tttccccaca cttgactctc agctcataga ggtcaagcac      120

tctcctgagt catctttatt tctcaactag ctctaacaca gtaaaacgtc attaggtact      180

tatcaaagtt gtctcaaatg ttct                                             204


<210>  210
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  210
atagctttga aagtgagtaa attgggtttt aaaaataatt aagggagtat tatttttata       60

tctatttcta aatgtaatgt tgagtcagtt tgacccattg attgggaatt gtaactggga      120

gaattgttaa tgtttaaact gaaaagcatg agattgttct gaaacttaag tacaggcaca      180

gagccaggaa caagcagagt gtgctggctg gtgacactca aagaggtgaa cctcagagac      240

ttgcatgtcg gaagaagtgt ctaagccagg gatggcaagt ggtcttaata gcaaatgcta      300

cctagactgc tgagttgaag attggaacac aagatgcggg ctcagc                     346


<210>  211
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  211
gtaccttatc tgtacgtacc tccaacaagc tgcagtcgac cagaggaggg gaggccagtt       60

cctctcccaa gggtgccaca cacccctccc tgttcatcac cagacaggcc cttccttctt      120

agccatatgc taaccttctc ctccctggga aatttcctct gcaggagcca aagcagatgg      180

gagctggagt tgctggagct cctggtctgt atgcagagca ggcatccagg aaaggagaag      240

agagtgtgac aatccagcac ctcagaatgg aggggcctcg tgtccagggc ggaaagtaca      300

gacgcaggct tgctgagg                                                    318


<210>  212
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  212
ttttgcatca tattcacatt agttatattc tcaaggtgtc tacattgccc aatatgcgat       60

atgctgggga tggtacacag taggtgctta ctacattttc ctctcagatg gcagaattct      120

tttgtctgag gcaataactg agattagtaa aataccacag gcttctaaac ataacagact      180

tgagcgtgaa tctcagcttc accatttttt aactgtatgg ccttaggcaa tataattaac      240

cttcat                                                                 246


<210>  213
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  213
aagtctggat gggaaatcca aggtattaca attgactcca gaaaacaaag ggttgaagca       60

cagggtggag ggggctgaag ccatgtggct caatggccat gtgaaagaaa caggccaacc      120

attagtccca gttcactcag tgggagcctg atacagacgg ccccacagtg aaagacgggt      180

taacaaaagt caagagctca ggataagatt cttctctggc gtaccaagat ttttgttctt      240

ggtgccacac ctcaccggat actgacaaag caaagcaggc aatccagaga agtgggaagg      300

ctcaaaccta tgt                                                         313


<210>  214
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  214
taaaggaatc atgtctcaaa atacaaactc ccatttacaa cttccagatg actcctttag       60

ctaccgaaaa ggttgaactc tgtagcatgg gcaatattcc tccagtctgt ttatctagtt      120

ttatcttgcc aggcatacct agggttggaa acccagctct gtttatttac atagcaatgt      180

ggctttactg ctttgagaat tattttcctc atctacaaaa tgcaggttcc tcagtgggtc      240

ctcagatgta gacaaataca gagatggcta acgtgggcct gacagtcttt acggagtctg      300

aagggcaggt aaactttcca tggtgatcca tccatcttct agcaaga                    347


<210>  215
<211>  203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  215
taaatatctt cctttcctta accacacgga tattgttttt caaaaggtct aaagggcagt       60

ggcctttggt gcctggaaca cttttagagt atttaggtaa tcaataccct ggttactatt      120

taaccatatt tgaaagagaa tcaagtgagt tctgtgcaaa tcaatgtgta tctgggtgag      180

tttccaacat cagatagatc tta                                              203


<210>  216
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  216
gctttattcc ttcaaggtaa tatagtgcgg tggcttctgg ctgagatgtt tgctgttgtt       60

ttcttcatct tgtctttgat gacttgtcag cctggggtaa ctgcacagga gaaggtgaac      120

cagtaagtgg gccatatgtc tctgcaaaac ttgcacgtag gaatcacctg ctggggaact      180

aagacacttt tatgtttgca gcagaggctg tgttagaatg gaaaataacc tcttttcatg      240

ttattactac tcctgtggag gaggatggga cagtgaaaag accgtgcact tggagtcaaa      300

ttggtctatg tgtaaatcac agctctaatg cttagaagct gaata                      345


<210>  217
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  217
ccacctctgt gaaacccgct ctgatattgc tccacccctt ctcccatagt ttcatctgtt       60

tatacattca ttcattcaac catgtccaca tgagtatcac atgtgaaaag aacaaaatca      120

gtatggtcac tgttcttgca aagcttacga tccagtggag gaaacaaaat aaacagccaa      180

agtccaaata tcatacttgg tcctctttta cttcctggcc ccatcagcga gatatattga      240

ctttacttct aaagcatatg catcacctgt tctccctcta ttactgtctc acttgtccaa      300

gccaccattg tctctcacct ggatactgca agagtatggt ggtctcttat                 350


<210>  218
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  218
catgtctcat acttttgttt tcactccaaa ctgcccagtg aagtaacatt atcccaattc       60

ttcctatgaa acagtgaaag ccctaagagt ttttgaaact ttacctggtt tactcaattt      120

gggaatggca gagcagaatt cagtccttga atatcctccc actgcaggtt catgctcttt      180

gatctaggtg taacatttac tctgagtaaa ctaggactct gggctaacag agatgaagca      240

agacaggctg gatattagga gaatctaaga gcaatctaac gaccattata ataaaatcat      300

gagttctaga cttaaaaaaa gggaaaaacc tgtttttttg cttat                      345


<210>  219
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  219
cttaatttca attcattttt ctgtgtctac ttacaacttt ggcactagaa ttcacaattt       60

ttttttagag gtatatctcc ttaaagggaa gggttctgac actgttacat gttctcaatt      120

gtttgcaaat aggttaataa ttattccagt gtctctaagt acatatcaac catgccagtg      180

ttcagcctcc ataattttat tagcttctgt gcttattttg gaaaaacatt tcccattacc      240

atgaaagacc tcagtttagg atggtttggt atgttagcct gatttctgca t               291


<210>  220
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  220
tcatgaggaa gatgaaaaga cagacccagg cagggatgga aggactgacg agaaccaact       60

tacaaagaga agttttgttt ttactacatt tctatgtgat caagttccca ggttaatatt      120

tgactaaact gctaggaatc cactgtgact ataatgctgg aaatgactta gtagggc         177


<210>  221
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  221
tatgggtctg actccatcac tgatttcagg agccctgccc tttcctccac accatgcccc       60

cttgctttca gaaaaaaagg cttgttgact gaatggttgt atgcacagtt caaagcagaa      120

acacacgatg acatcttttg agatactcta acagtgagaa cttgaaaatg aagttaaaaa      180

ttaagcggca aaaccaagcc gaggctttct gagaaagtgg ggccaaacct gttgccgtct      240

gactgc                                                                 246


<210>  222
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  222
agaacttttt cctgctgcct cttggtgctt ttgcctatgg cccctattct gcctgctgaa       60

gacactcttg ccagcatgga cttaaacccc tccagctctg acaatcctct ttctcttttg      120

ttttacatga agggtctggc agccaaagca atcactcaaa gttcaaacct tatcattttt      180

tgctttgttc ctcttggcct tggttttgta catcagcttt gaaaatacca tcccagggtt      240

aatgctgggg ttaatttata actaagagtg ctctagtttt gcaatacagg acatgctata      300

aaaatggaaa gatgttgctt tctgagagat gcaggtggat tct                        343


<210>  223
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  223
tctcttttct ttgtatttta agcccagtgg gcaaatcctt ttgatccatc caagacagaa       60

gacagttcca gcttcttaat agacaagacc accactgttc aagtgcccat gatgcaccag      120

atggaacaat actatcacct agtggatatg gaattgaact gcacagttct gcaaatggac      180

tacagcaaga atgctctggc actctttgtt                                       210


<210>  224
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  224
ggaattgaaa gtaagccaca gatgagctag agaaggctgc tgataagaat atgttgcaca       60

aattatctgg cttatccagg tgctctgccg tgcgtctaac ccgttgagcc tgtgtgttat      120

ctccacgtga cttaatctgt gagatcttgc cacaggttaa cttgctcgtg tgtacaagag      180

gcggacattc ctttcagtgc agtcggaact actgttgatc aagcagagag tggcagttac      240

tgaagtgtcc ctgcaaagtg gaaacacacc tgttccttat acagttggct ctcctaacct      300

cagatttcgc atctgcagat tcaaccagcc acagatggaa aatatg                     346


<210>  225
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  225
taaccattta ccttttggtg ataactattt accttagtca tttctgagga ctgacccaat       60

gctgccctct agtgataaat cttaaaaggg ctgccatgag ctattgaaat gtgatgactg      120

gtgactcttg gagggctgtg taataaggcg tcatccatgt cccatcagct taaaatgagg      180

ggattctgaa tctcttc                                                     197


<210>  226
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  226
ttttgatatt tgtcaacttc ataggttaaa aaaaaaatag gtattttggc acggttttaa       60

tttgcctttc tcttattgag tcagattgca catttttttc atacattgaa aggccatata      120

tatgtttttc ttcgcgaact attcatttcc tttgtccatt gttctattga gtctcctgtc      180

tttctcttac atatttctat gatcacttca taaattagtc tttgtctctg atatgaatta      240

cacatatttt tcccagtttg tcattcttcc tttgacttta tgtggtatgt tttagtggag      300

ttactttcat atttaattta ttcttcactt ttt                                   333


<210>  227
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  227
ggcatgtcct ggataacttt ctgagtcaat atgtgggaac ttcctcattg tcatagctga       60

ttaattctta ctgatgaaca tttgggtgtt tccaatcttt cgcactagaa ataatgttgc      120

aatgaatatc cttgtttata tatcattttg taagtggtta ggtgtacctg aggattaatt      180

cccagagtga tctgagtcaa aagataatca ctttgtgaca gtgctaaaat tgccctattt      240

gtattatttt gcactttcac cagcagagta agagtacttg tttctcacag ccttgcgaca      300

ggaaccacag gcc                                                         313


<210>  228
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  228
gttagctata atagattctg gattgtcaca acagtgaaga gaaagtggaa atccatgaaa       60

taggaccgtg agtaaattac cgtctgatct atttcacacc ttcttctgtc tcaaacccac      120

acacactccc tttccgggag tgtaaggaag actagtagat aagacctgta ccagaacaac      180

ctcagctgac atccactata aaatcactca ttagtgcact attggttcat gccttttacc      240

cttggctgcc tcttgttttt tactcagtca tatttgacct caccaagaca cgactgtgtg      300

gactgctcta ggctggcaca ggcccctctg gagagctgtt gca                        343


<210>  229
<211>  220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  229
taaagtaccc tataagcaac atgacgtact taaaataata acaatagtag taatagcaag       60

gtaggaaaag cctgagatgt ggagccagac atagcaagta caaatgtgca gttactcgtc      120

cctggctgac gctggacaaa tgatgtaatc tcaatgtgtc tccatttcct cagctgtaaa      180

acagattatt ttcaggatta aatgagattg catatataaa                            220


<210>  230
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  230
gacctgtcct cccagatggt ggagatggac aggaggacta tctacccacc cgtccccacg       60

gccctgaccc tctgacctca ccctctccgc tgatttcttc atgttagttc aacattaacc      120

cagaggggtc aggacagaca attcctcagt gacccaggag ctgacacact atggcgcacg      180

tccgaggctt gcagctgcct ggctgcctgg ccctggctgc cctgtgtagc cttgtgcaca      240

gccagcatgg t                                                           251


<210>  231
<211>  158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  231
tgaggccgct gtcccatgac ccccccaccg ccttacagtg ttcctggctc ctcagcaagc       60

acggtcgctg ctccagcggg tccggcgagc caacaccttc ttggaggagg tgcgcaaggg      120

caacctggag cgagagtgcg tggaggagac gtgcagct                              158


<210>  232
<211>  157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  232
cacagagaag caagcgagga acgccacagc cccttcgctg ctcacagcct catttcaact       60

ctgagcccct cctcacaggg ctggcaagag gagcggcctc agcctttcct gggggtctct      120

gtgcctggac tgtgtccctg tgcagctcca tgacatg                               157


<210>  233
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  233
ttttatctaa ttttacgtag caattacgtt ttgtgcattg gttgacaagc ctctgtatta       60

tcctcagaac agaaaatact gtttaaggga aattaagagc ccgcagttac taaagtgact      120

gcgccaccaa gtggacaagt gtaaagccac tgtctggaga tggaaggatt cagctttgct      180

ttataaatgg gaatttgacc tttaaaaatg tcccttttgg cacgcacgcg cgcgcgcgcg      240

cgcgaacaca cacacacaca cacacacaca cacacacaca cacacacacg gctgctgccc      300

tgcagatttg cttgttcttg tcataaagct ttcattgttt ctctagctct a               351


<210>  234
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  234
aaaagaagga ttaaatattc atttatcctt ttgcttctga cttgttatgt gggcaagtgc       60

cacatgaggg agtgctggga cctcatatca agaaaaatta aaacctacct aatgcgttcc      120

aggaatgttc agcatattag caaattctta ttaaactgt                             159


<210>  235
<211>  213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  235
taatgccttc caaggctggc atgccaatgg ctgctattaa gatcgttttc tctcattcta       60

ataacacact tagagatgat tggtaataaa aactctcttc aaggcttctg cttctccccc      120

ttcaaaatgg agatcaaaga atcatgctgt gagggtccgt caagaagaaa agactttcag      180

caacagagca tgtggtgtgg cataaaataa tga                                   213


<210>  236
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  236
ttaaaagtaa ttgcctgaag ctgctgttta tcacataaaa agaagacaaa ctagacatag       60

catatcttct taaactctaa tctaaactct atgcatttgt ataccatctt gattttcaag      120

attggggaag tgaaacgaaa actatgttca cacaagaacc tgtacgtgaa tgtttgtagt      180

ggctttattt agaatttccc cccaaactgt aagtattcaa aatgtctttt agcttgggaa      240

tgactggaca aatgatagta cccctgtatg atggaatatt attcatcaac caaaaggaac      300

aaactattga cacgtacaac aacatgagaa                                       330


<210>  237
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  237
tcttagtatg acagtaaatg cttatgttca tggtgtagga aacagcatta aatgccagat       60

aaccatctta tccggatgaa ccagactgga ttgttggctc aaatgttttc ttcctgctgg      120

cttttcgtgt tatcattcat tttgattact gttgtctaaa ctttcacttt agatttcaat      180

ttgtctatgc agcattaatc tttcaacttt gctgtttcat ctctccttca aagcacttca      240

tctctcttcc caaattagtt ttcctttgac tttcatattt caaag                      285


<210>  238
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  238
gttatgatag tttctttttt atagtaattg cacaggggaa gagctaaagg atagaactct       60

gtcattgtga accctgaaag ctcagaaaaa ggggagggaa atgagcctca aggtgatgac      120

cagtaaccaa taaatcacgt cactctgccc tttgacaaac atttctttat ccatggctcc      180

ctcagtcccc tgaatgcgaa attgctttga ggagattgt                             219


<210>  239
<211>  166
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  239
tagtcagcct ttcctccttt gctcagctgc tctgattcag agctactctg attttactct       60

ggaggacaca tgcaaccaat gtctgaacag tcatactcaa tccctgcatt gaggtagaaa      120

gcactgattc ctagaggctg atctgaatca tgcaactgta ttgaag                     166


<210>  240
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  240
acttaattga ataaacaagt aaaagccatt cccaaaagta aggtttactt gttaagatta       60

acaaaaaata atgtgagaat tctgagaaat ataatcttta aatattggca actggagtga      120

actcttaaaa ctaactaggt tttatatgtt tgactagagc aatgacataa taaggtggtt      180

aatcatcact ggacttgttt tcaaaaagcc aactacttta agaggaataa agggtggact      240

tgttgcagtt gctgtaggat tctaaatcca ggtaagaacc attgagattc tctaattttt      300

acatatattt ta                                                          312


<210>  241
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  241
ggctcacctt ctctctgggc aaacaagttg ggaacaagtt cttcctgacc aatggtgaaa       60

taatgacctt tgaaaaagtg aaggccttgt gtgtcaagtt ccaggcctct gtggccaccc      120

ccaggaatgc tgcagagaat ggagccattc agaatctcat caaggaggaa gccttcctgg      180

gcatcactga tgagaagaca gaagggcagt ttgtggatct gacaggaaat agactgacct      240

acacaaactg gaacgagggt gaacccaaca atgctggttc tgatgaagat tgtgtattgc      300

tactgaaaaa tggccagtgg aatgacgtcc cctgctccac ctcccatctg                 350


<210>  242
<211>  157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  242
tctgtgagtt ccctatctga agggtcatat cactcaggcc ctccttgtct ttttactgca       60

acccacaggc ccacagtatg cttgaaaaga taaattatat caatttcctc atatccagta      120

ttgttccttt tgtgggcaat cactaaaaat gatcact                               157


<210>  243
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  243
ggtcccattt gttctcactg ccaccgaaag catgtttata gtcttccagc agcaacgcca       60

ggtgtctagg cacagatgaa cccctcctta ggatccccac tgctcatcat agtgcctacc      120

tttgttaaag tactagtcac gcagtgtcac aaggaatgtt tacttttcca aatccccagc      180

tagaggccag ggatgggtca tctatttcta tatagcctgc acccagattg taggacagag      240

ggcatgctcg gtaaatatgt gttcattaac tgagattaac cttccctgag ttttctcaca      300

ccaaggtgag gaccatgtcc ctgtttccat cac                                   333


<210>  244
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  244
ctttaccttc cagaggaaac tgcctgggga tatgaggaga ctgatgtcct atttgagtat       60

atttttctca actatactgt aactcaaaac agagattcag ctctcattct ctggcatctc      120

agaattccac acagcagttt gtgactaata gttgtcttgc cagcccagga aagtggccca      180

caggtcaggc catcccgtgg gacacaggat gaatttttct tctctgggtc attgtcatgt      240

cagaccccta ttcacttcag tagggatggc accaggttca agaggccaaa gaagagatgg      300

agtcagcaaa ca                                                          312


<210>  245
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  245
tgcctgatta ctacaaacca agtgcacaca gggtctcatg atctgggcct tggttatctt       60

ctcaggttta tctcctcccc tgccacattc actgtgtgcc agccatacga atctacatga      120

ggttggagca cactgcttcc tcatgtttgg gctctgcatg ctgctccctc tgctggtaac      180

accctttcct cacttgtcaa cctggaaaat tcctgctgat ttttcagctc ttgggcccaa      240

tgcttcctct ttggtgtgaa accttccaca acttctctag gcagacttag gcactctgtc      300

tatattctca gtgcactctt tacactacac cttggtagtt gcatggct                   348


<210>  246
<211>  271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  246
gggttggtag tgatgccagt agtgatggtg atagtggtag tgatggtggt ggtggagcca       60

ctatgtggct ttttaaggaa gggaaataga gaagccacgt atggtctaga ggtcacgtga      120

gggaaggaga ggaagtcatt ctggtgaagg caactgtgtg taattctgtg tgaatagtcc      180

ctcattgttc cccatgaccc ttaggacaaa tctaccctct ttagtcttac atacaagtct      240

ctccatggcc aaatccctat tggcccttca g                                     271


<210>  247
<211>  344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  247
ctaaaatgtt caagtgggaa attacagtta aataccatgg taatgaataa aaggtacaaa       60

tcgtttaaac tcttatgtaa aatttgataa gatgttttac acaactttaa tacattgaca      120

aggtcttgtg gagaaaacag ttccagatgg taaatataca caagggattt agtcaaacaa      180

ttttttggca agaatattat gaattttgta atcggttggc agccaatgaa atacaaagat      240

gagtctagtt aataatctac aattattggt taaagaagta tattagtgct aatttccctc      300

cgtttgtcct agcttttctc ttctgtcaac cccacacgcc tttg                       344


<210>  248
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  248
tctttgcccc tattttaggg ataaggattc tgaaatgtgg agatggtaag taaaattgca       60

caactgaaga atgagttaca tgacttggct caaatactgg tcattgaact ccagagcctg      120

aatattctta accacttaca tgatgcaagc tcaccaaata aatagttcga atgtattgtg      180

acagagcggc attgatattc atctattcat gtggctttga gtaggaagaa gaaaggatat      240

cattctgacc agaggggtga aaaacaacct gcatctgatc ctgaggcata atactattaa      300

cacaattctt ttatgtttca gttcgatgaa tttaaacctc ttgtggaaga g               351


<210>  249
<211>  280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  249
tgcaacatta atctaaaaac ctcaatgacc caaatagaaa aggaaaaaag ctttctgaac       60

agccaaacag agattccaaa gttcaggcac caaagttcag accctaacag ttatttacaa      120

gggtcagtta accttttgtt ctagtgggat aggattccca tggtgagatt tgaagaactg      180

tggaaccact gtttcaggtt ctttttccac tttgccaccc gtttgaaatt ccatccatta      240

ggaattaact ggcatgatgg gagtcccttt tataataaaa                            280


<210>  250
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  250
gagttcaaga ccagcctggg caagtctctt taaaaaaaac aaaacaaaca aacaaaaaaa       60

ttaggcatgg tggcacatgc ctgtagtcct agctacttag gaggctgacg taggaggatc      120

gtttggacct gagaggtcaa ggctacagtg agccatgatt gtgccactgc actccagcct      180

gggtgacaga gtgagact                                                    198


<210>  251
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  251
ctctattttt aaacttctcc cacaaagatg agaaaacatt taaaaatcat tggggctatt       60

tttctgttta ccgagtaaag agaatctcta aaccatattt ataactctta ctctaaatat      120

ttgcatttac cctcatgcca gagcccgttg atgactgact aaacagagtt tcaaagtttg      180

aagaacagga aatttagaaa tgactaacaa ttatgtaggt tta                        223


<210>  252
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  252
gtgaacaaaa gaacaacccc tgaatggaca gatttgtggc tgttagttta atttggctaa       60

tcaagaagca actgcaccaa tgtagtaagt ggccatgagc aagtttctct acaacaaaaa      120

acattgcttc acagggtggt tgagtcactg gaaagatttt catatttaaa ctcctttagc      180

atcccctttg tctactcacc taaaccaaat acaaaataat atcaatggga attagtactg      240

gtttgggact tggatttgag tggggaggc                                        269


<210>  253
<211>  152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  253
ctacactctc gtttcttctt ttaagatttg ccaatgatga tctgtcagag gtaatcactg       60

tgcatgtgtt taaagatttc accacttttt atggtggtga tcactatagt gaaatactga      120

aacttgtttg tcaaattgca cagcaagggg cc                                    152


<210>  254
<211>  213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  254
ctcagggcac tgtgtgggag ggtgagaagg agggaggccc acagaggcat gacctctgat       60

tgccactgtc acctgggccc tgctctctga agtctctgcc aagcggggag gtggccgggg      120

gagggccctg ctctgtgcag cctcccctcc cccggcccgc agagttgagc acagagggac      180

agaggcacgg aacccccaga aatgtccctc ctc                                   213


<210>  255
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  255
ggcaccattc catgtgcatc gtatgtagta actcttaatt ctcacgataa ccctgaggta       60

gatattatta ccccgttcta caaaaggaga aacagtcctg gggagacagg ataagtcacc      120

ggccaaggca cacagctagc tacatgtggc ccccgcgtga cggctggtct ctgtaggcga      180

ggctttgtcc agatgcgtgg gtagaaggtc tggcccggaa agaggaactg acagcaaggc      240

taagccaatg tctgcccctg ggggcagaaa gtcacctcct gctctccctc cactgtccac      300

agaggtagct cagacagggt gggggtcaca ggagaacgaa gggagaa                    347


<210>  256
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  256
aagcagcaag agtgagatga gtcgtcaggt aaatcagccc tcgataaaat agcaggaacc       60

tgttcaccca aaactgaaat gagtcgtcag gtaaatcagc ccttgataaa acagcaggaa      120

cctgttcacc caaaaccaaa atgagttgtc aggtaaatca gaccttgata aaatagcagc      180

gcctgttcac ccgaaaccga aatgagtcat caggtaaatc agccctggat aaaatagcag      240

gaacctgttc cgccgaaacc aaatgagtcg tcaggtaaat cagcccttga taaaataaca      300

gcacttgttg accagaagcc atgggaccag caggcagtga gatgacaca                  349


<210>  257
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  257
agatcaggat tagggcgatg gcccccgcgc gttgcctgcg gagcgaggcg cactgagtcg       60

cccaggaatc cggcctctcg gcgactgtgc gggagagttt atggggatgg gcggggctgc      120

ttctgagcag gagtcgccgc ccccaccccc accgttccgc ctctgggccc gcaggctcct      180

cccgggagcg ctttcccctc ctgttcaacc gccggggtac aggtggcttc gtccaccgag      240

gtcccctcac ccacgctgag gcgtcggaag ctgcggacac tgctcgcttc agggctttgc      300

tcagct                                                                 306


<210>  258
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  258
gcaggcgcct cccaggagtg gtcagtggtc aatcagctaa tgaagctgca taggacatga       60

cccttgttta ccgcagaatg cccagagctg gcaggatgtc ttatatgcag gaagtaccca      120

aaatgtattt attgaggaag tgatgatgga taagaggaag acggagagcg agggagagag      180

gggctagggg cccctgcggt gtaaaggggg tgtggctggg agtgtgcagg ggaacaggga      240

tcatttcaag gttcctatct gggagaaaat aaaaaggttt acagttagtt gagataagcg      300

tgggaatatg cgaacatttt taaagaataa aaagtttagc tttaaatttg                 350


<210>  259
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  259
ataaagaacg ccgtcagcac agagcagacg ctgggtgttc gcgctcttga gcgtgcgctc       60

tgcggggcgc gggctggtgg cgggcggggg tcgccggctc cagctcaggt tcccgcgcca      120

ggaccgcgtc cagaaccttg tctccggaag cgggcaacgg ggtggttgta tcacaattag      180

tggcatttgg ttttccttct tctgcattgt gggttttact tctctggggt tg              232


<210>  260
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  260
gctggtgacc tccagagagg gagtctctga tgtcccgctg gggtggatgt cctgagaccg       60

ggaaggggga agagacccac tgaaatccta tctcccagcc tcacctctgc tgtctcctcc      120

acgcttcctg tctccagagc cccgagttca gcataagcag aaagcggcct gttccctctc      180

tagggagagg agggttgcgg tctggaggtc tggctcgtct ttatctgcgc attctcccag      240

cctcctggct tcagacctca gcgaggcggc ggctgccggc cggctctcct cttcctgcct      300

gcagacctgg cctgctgctt ctttctcctt cctccctccc tgcctgcc                   348


<210>  261
<211>  173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  261
tggcaccaat acctgccgcc tacgactgtt gtgaacactg aatgggccaa caaacctaaa       60

cgttaaatga actgataacg ccgtcagcac ggagcaggcg ctgggtgttt gcgctcttgc      120

gcgtgcgctc tgtggggcgc aggctgacgg cgggcggggg tcgcctgctc cag             173


<210>  262
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  262
ctcgccgcgc ggcgggcctg acttctagcc acgggtctcc gcagttggcc cagcgcttcg       60

ggccggtgtt cacgctgtac gtgggctcgc agcgcatggt ggtgatgcac ggctacaagg      120

cggtgaagga agcgctgctg gactacaagg acgagttctc gggcagaggc gacctccccg      180

cgttccatgc gcacagggac aggggtgagt ccgcgtcc                              218


<210>  263
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  263
gagcagagca gctggaaccc cccgagcgcc ctgcagacgc agcagcctct tgaggggagg       60

gtctccccca cctcgggctg gacaaagaca gcttttcccc acgtccctct gggttctcta      120

gagcaacagc aatacccgcc cggcaggggt g                                     151


<210>  264
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  264
gaagattagg gctttcatct tcatttagac ctgacccctg actgctttct atctaatcct       60

tcactaagca actccttcaa ctggaaatat actatcctat atagcataat attcaaaact      120

acattcttca ctgggggttt ccagatgaaa gcccacattt tgttaacatg actcactgag      180

acagtctttg tttctcctag ggcacagtcg tagtgccaac tctggactct gttttgtatg      240

acaaccaaga atttcctgat ccagaaaagt ttaagccaga acacttcctg aatgaaaatg      300

gaaagttcaa gtacagtgac tatttcaagc cattttcca                             339


<210>  265
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  265
ggagtgggct gcctggggtt catacgtcac cacacttgat aatttacaga agcctttcac       60

gcgttttttc ctgtgtctca aacggggtac caggaggctc agggaaacag cgcaggcgcc      120

tccccggtgg cttctctctg gcgccctctg gtgggcgggg cccgggtgag cggggtcccc      180

tcggggcctc agggagccgc agccccagcg gaaccaggag ggcgccctcc gcccagccgc      240

gctgccactt ccgggttgtt tgctcccgga gccataaccg cagctcagcg tgcgggcaga      300

gccggctgac aggagacagg acacagca                                         328


<210>  266
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  266
aaatcgttct ttgtcattac ccatcccagg ttgtcctcct gtctccttgt ggtgaacatt       60

ggcctgtgac cctgttttat gattaacaga gaggtgacat ttgtgctaac gtggtacaga      120

cctttaatcc cactgtagaa gtttaactcc ctgtaa                                156


<210>  267
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  267
ttatagaagg ggatggtatc cccagcaata ttcagcaaca ttgctgtaaa aagaagaaaa       60

tctgagtgaa ggtttgactg gtttcccatg agaggcagac agggtcaagg tggggtcaca      120

tttactctaa ccagtctcct ctctcatatt tgtcttctag gctaactgcc aggcggccaa      180

aggacagtat gttcacacgg gttcttctgg ggctgcttcc acccagtcgc tcttcacagc      240

ctgctatacc tactagggtc caatgcccgc cagcctagct ccagtgcttc tagtaggagg      300

gctgaaaggg agcaactttt cctccaatcc tgg                                   333


<210>  268
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  268
gcctggggtc ccggcttaga ggacctctga gagctccggg gccccttctg ggtcgtggtt       60

gcctcatcgt ggtcgggtgg gtctccaggt tctcccaggc tcagtcccgc aggcgccaaa      120

tctgcgcagg agagcactag caaccgatga cgtattgagg cccacacctc tgggattggc      180

tgtcctgctt cgacagcctt gaaagtgggt aagctgggtg gggggctctg ggagaggtca      240

gtgctgagta aggcaattcc cagcagcttg agccccacca ggtcactcca gtattcctcc      300

ccattctttt tttttttttt tttttttct                                        329


<210>  269
<211>  161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  269
cctgggaggg acacccgcct acactctgca agaaactcaa aaagggagat gaggggatcg       60

tgggagggag gtagggaggg aggagggtgc cactgatccc ctgaacccct gcctctgcct      120

ccagagtgcc cctccggcct cgccatgagg ctcttcctgt c                          161


<210>  270
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  270
agagttgtga gcccttaaaa ggaacaggga ttgctcactc ggggagctcg gctcttgaga       60

caggaatctt gcccattccc cgaacgaata aaccccttcc ttaactcagc gtctgaggaa      120

ttttgtctgc ggctcctcct gctacattct gagtggggaa agggactaag gtggtctgag      180

gaccccacag agtcaggaag a                                                201


<210>  271
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  271
gagagtgctg aacggggagg ggctttgggg ctaagggaag tgcccgggac cccacctgac       60

cccaacgctc acgggacagg ggcagaggag aaaaacgtgg gtggacagag ggaggcaggc      120

ggtcagggga aggctcagga ggagggagat caacatcaac ctgccccgcc ccctccccag      180

cctgataaag gtcctgcggg caggacagga cctcccaacc aagccctcca gcaaggattc      240

aggttggtgc tga                                                         253


<210>  272
<211>  286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  272
agggaggaga ccacccctca tattgtctta tgcccaattt ctgcctccaa agaaagaaaa       60

agtaaaaact aaaaggcaga aatgaaatcc acaagcagac agcccgcgcc acaccctggg      120

cctggtggtt aaagattgac ccctgaccta atccgttagg ttatctatag attacagaca      180

ttgtatagaa aagcactgtg aaaatcccta ttctgttttg ttccgatcta attaccggtg      240

catgcagccc ccagtcacgc atcccctgct tgttcaatcg atcacg                     286


<210>  273
<211>  202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  273
cggagtctcg ctctgtcgcc gaggctggag tgcagtggcg cgatctcggc tcactgcaag       60

ctccgcctcc ctggttcacg ccattctcct gcctcagcag gactacaggc gcccgccacc      120

gcgcccggct aattttttgt attttcagta gagacagggt ttcaccgtgg tctcgatctc      180

ctgactttgt gatccgcctg cc                                               202


<210>  274
<211>  341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  274
attttgaacc cctgcccatc ttcctggcag gcccagcccc agcccagggg accccagacg       60

tctccagtgc cttggataag ctgaaggagt ttggaaacac actggaggac aaggctcggg      120

aactcatcag ccgcatcaaa cagagtgaac tttctgccaa gatgcggtta gaacccttcc      180

cagggcacgg gagagctggg gtgtgttttt gggtggagcc ctggcagatg gtccaagatg      240

aacagattga aaaaaaaaca agtcctggag aggctgacaa catccctctg gtcacacagc      300

tagatctcaa ggtgctcaga cttcaaggac agtttccctg a                          341


<210>  275
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  275
tgagaaaacc gacctctaag agaacttctc agagaagctc aaaaggtgta tgtgaggagg       60

gacagggaaa aacaaaaaca gaagtcaaaa ccaatgttat ctactttcca gcaggtggct      120

ccaaacccat atgctactaa atgaggcttc cagggagcca gaaactataa aaggtcccaa      180

gcctcccaaa cccagtttag agaaaccaaa ccttcagcta gaggacccaa gtctacattt      240

cccag                                                                  245


<210>  276
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  276
aattcttctt caaaggttca gcttgcttaa gtttccttgt tctttgctcc ctgctttcaa       60

ggccagactt ccttactctc tgtgttctcc ctgcgctggt aaacaacctt cccgccagtc      120

gttatctata gagcccacat tccacatctg ctacccactc tgtgaattac ccctcccatc      180

acaatggctt ctcccggcaa aactgatctt cctgccttcc cagcagtgta atcacattcc      240

tgcacttttc aagttagcca accgggttca gcttagattg tacggtccaa ctctagccaa      300

tggagtcagg atacagtagc agggacaagc tgcgttagac ataaaaacct                 350


<210>  277
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  277
aaattctttg gcaaatggaa gggatttatg tcctcaatcc tcatgtctct tgccatcaga       60

atagggttgc ttattcttgt aggatgctgt gtcataccct gtgccctagg attaatacaa      120

aagctcattg aaacagctct ccccaaaacc tccctcaatc ctcctcctcc tcgttccagt      180

gagctttttc ttttagaaga cccaagtaga ataacagagc caaattatgt taaaagggtt      240

t                                                                      241


<210>  278
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  278
ccctctgcag ctggccccag aaacctgcca gttattggtg ccaggtctgt gccaggaggg       60

cgaggcctgt catttctagt aatcctctgg gcagtgtgac tgtacctctt gcggcaactc      120

aaagggagag ggtgacttgt cccgggtcac agagctgaaa gggcaggtac aacaggtgac      180

atgccgggct gtctgagttt atgagggccc agtcttgtgt ctgccgggca atgagcaagg      240

ctccttcctg tccaagctcc ccgcccctcc ccagcctact gcctccaccc gaagtctact      300

tcctgggtgg gcaggaactg ggcactgtgc ccagggcatg cactgcctcc a               351


<210>  279
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  279
ccgaggaagg cctagccgct gctgctgcca ggaattccag gttggagggg cggcaacctc       60

ctgccagcct tcaggccact ctcctgtgcc tgccagaaga gacagagctt gaggagagct      120

tgaggagagc aggaaaggtg ggacattgct gctgctgctc actcagttcc acaggtggga      180

gggacagcag ggcttagagt gggg                                             204


<210>  280
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  280
acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact       60

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      120

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      180

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      240

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      300

agt                                                                    303


<210>  281
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  281
tggccccaaa tcacacacca tccataattc gggctcaggc acctggctcc agtccccaaa       60

ctcttgaacc tggccctagt gtcactgttt ctcttgggtc tcaggcgctg gatggggaac      120

aggaaacctg ggctggactt gaggcctctc tgatgctcgg tgacttcaga cagttgctca      180

acctctctgt tctcttgggc aaaacatgat aacctttgac ttctgtcccc tcccctcacc      240

ccacccgacc ttgatctctg aagtgttgga aggatttaat ttttcctgca ctgagttttg      300

gagacaggtc aaaaagatga ccaaggccaa                                       330


<210>  282
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  282
agagtgaggc cccaggacca gaggattctt gctaaaggcc aagtggatag tgatggccct       60

gccagggcta gaagccacaa cctctggccc tgaggccact cagcatattt agtgtcccca      120

ccctgcagag gcccaactcc ctcctgacca ctgagccctg taatgatggg ggaatttcca      180

taagccatga aggactgcac aaagttcagt tgggaagtga aagagaaatt aaagggagat      240

ggaaatatac agcactaatt ttagcaccgt ctttagttct aacaacacta gctagctgaa      300

gaaaaataca aacatgtatt atgtaatgtg tggtctgttc catttgga                   348


<210>  283
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  283
tggccagttt cctatagaac gcctctaaaa gacctgcagc aatagcagca agaactggta       60

ttctcgagaa cttgctgcgc agcaggcact tcttggcatt ttatgtgtat ttaatttcac      120

aatagctcta tgacaaagtc cacctttctc atctccagga aactgaggtt cagagaggtt      180

aagtaacttg tccaaggtca cacagctaat agcaagttga cgtggagcaa tctggcctca      240

gagcctttaa ttttagccac agactgatgc tcccctcttc atttagccag gctgcctctg      300

aagt                                                                   304


<210>  284
<211>  259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  284
ctcaattttt ctatctataa aatagggcta ataatttgca ccttataggg taagctttga       60

ggacagatta gatgatacgg tgcctgtaaa acaccaggtg ttagtaagtg tggcaatgat      120

ggtgacgctg aggctgatgt ttgcttagca tagggttagg cagctggcag gcagtaaaca      180

gttggataat ttaatggaaa atttgccaaa ctcagatgct gttcactgct gagcaggagc      240

cccttcctgc tgaaatggt                                                   259


<210>  285
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  285
tgcagatggg aaaacaaagg cccagagagg ggaagaaatg cccaggagct accgagggca       60

ggcgacctca accacagccc agtgctggag ctgtgagtgg atgtagagca gcggaatatc      120

cattcagcca gctcagggga aggacagggg ccctg                                 155


<210>  286
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  286
gcagatggag aggctgcagc tgagctccta ttttcataat aacagcagcc atgagggttg       60

tgtcctgttt cccagtcctg cccggtcccc cctcggtacc tcctggtgga tacactggtt      120

cctgtaagca gaagtggatg agggtgtcta ggtctgcagt cctggcaccc caggatgggg      180

gacaccagcc aagatacagc aacagcaaca aagcgcagcc atttctttct gtttgcacag      240

ctcctctgtc tgtcgggg                                                    258


<210>  287
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  287
aactcttcac tgtgaaagga ggaaaccaga gtaggtgatg tgacaccagg aaagatggat       60

gggtgtgggg gaatgtgctc ctcccagctg tcaccccctc gccaccctcc ctgcaccagc      120

ctctccacct cctttgagcc cagaattccc ctgtctagga gggcacctgt ctcatgccta      180

gccatgggaa ttctccatct gttttgctac attgaaccca gatgccattc taaccaagaa      240

tcctggctgg gtgcaggggc tctcgcctgt aaccccagca ctttgggagg ccaaggcagg      300

cggatcaaga ggtcaggagt tcaagacctg cctggcc                               337


<210>  288
<211>  317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  288
ttatttcttt agcctcacca gcttcctttc aaatgcgtgg ctaatggctt ccctatcagg       60

cagtgcagac tgaagaacat ttccatggtt actgagagtt ctactcagca cttctgttgt      120

gaaggattca ccttccccaa gctgtgtgcc acatttcaca cagcaggtgc acagggatgc      180

cagctctctt ttttccaccc cttctcttta ctctcctctt ctttgcatca ctcccctctg      240

attcacttct cttcctttcc cccttccctt cctgtcccct tcctacttca gaacagaaca      300

ggcaacctat ttcacct                                                     317


<210>  289
<211>  237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  289
attttataaa tataactttt tataatattt agaccttttc ctttgagcaa aattagtaaa       60

gtgttcttac agtagcataa gtcagaaaag caaaacaaaa caaaaaccct tgtatctcta      120

gggggcatag gagaccagga tctaaatact tcgaaaaggt tttcaggtta acaatatgtc      180

catttcgaag tcacatgtta actttaattc taaatttatg ctagaatcca ttcctaa         237


<210>  290
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  290
gtctgcaggg cttctgtgct gggcccatac aggttacaag cctcccccca tctcagaccc       60

caagagtaca ctccatttac aaggtggagg aggtagttaa gccctgggcc tcaggagaga      120

atgtctattc ctacgcatgc caaaaccaca tctgtaggaa cttaagcatt ttctgctgtt      180

gtgtcattct cattgttatc gtggtgattg ttgtaaaaac tgctatatga gccttggaaa      240

catgaagcta agtcagaaaa aaaatcagat acaaaaagtc atatgttgta tgatttcatt      300

tatgtgaaag gtccagaata ggcaaatcta ttagatgaac tgctagcagg g               351


<210>  291
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  291
actgatttaa ccttacacgt ggctcccaag gtcaccgaag cagaggagga gagagctgga       60

atgtcttacc aaggcttctg tgaccatatc tggaaggaac atatatcact gctggcctca      120

tctcattgcc caactggtcc catggcccca gcctcacggc aaaggggctg g               171


<210>  292
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  292
aatatcattt gcattttgca aagggagaca ctgagtttca gacagctgct tttgcacagt       60

atgaggcagt gagttactgc acagccttga ttccaaggtc ccctcattta caattgaatc      120

ccctttggga aataggtcat ttgcaagtca gggagtccct ggggtgcagt ggagtagaaa      180

atggtgctga gttcaatggg ataaaaagaa taaaccagaa atagtttcat tacaggcact      240

tcattttacc caggggtaga acaattttta aattgatttg catcttccaa attttcgatc      300

aaaagaaaat ctgaagtgta tggaagctgt cat                                   333


<210>  293
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  293
cccacattgg gagttcactg gggctgtcat taagtgaacc cacactgtgc tggagaaagg       60

gaggacgtag ccttgggggc gtgcccacag tactttgacc agcaaacgca tttcaacata      120

gcagataatg agaccacatt cgtccctcct gacacctggc ctttgtcgtt tggcaggcta      180

cttagggcac caggggctac aaacccattt gcaaaaata                             219


<210>  294
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  294
ggatcataca accacagaca caggcaacag ccacaaccac accaccacct gctgccagca       60

tcagaatatt ctcaaagcga gcctgggctt aagtcacaat ccaccatttg tttgtgggac      120

aggcagtcag ggcagatact ttgaaaaaaa agagcccttc ctgtttgctg tgcattgtct      180

tcataccagt tcccagaatt gacctgacaa atattgacca ggttgctgtc atcttcaaac      240

accattttcc tgtgggtaga ggtgatgcag tgctgaagac ctgggcccct gctcagtgcc      300

tttgctctgt aagtactttg cctgtgccca aaatgagggc aggggca                    347


<210>  295
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  295
ccctgcccag ccccaaactc gaactaaaag taggaaactc cctgttccta gacaagcgac       60

taaagcctcg gcagcactat ttggacagca tcaaggagct ttatggagct tttgcttttt      120

ctgccaactt cacagattct gttacaactg ggaggcagat taatgactat ttgagaaggc      180

aaacatacgg gcaagtcgtg gactgcctcc cggagttcag ccaggacacg ttcatggttc      240

ttgccaatta catcttcttc aaaggtgagg cttgctctga cagaattatt gccactgcct      300

ctgcaagtaa atgctcttac agcagagagc cagct                                 335


<210>  296
<211>  209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  296
attctgggtg cttcaagagc tttcgggagc ccagctgttc cccaactaaa ctccagcagc       60

atccctccac caggcattga gctgatccaa aatgtcacct ctatctcctt tacacacagc      120

cctccccctg cctttgtcag gagccagtgt tacaatgcat gtaatatcct atcacttcat      180

aaacccttaa taagtgagaa tattatact                                        209


<210>  297
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  297
cttcaggttt tcaatctcct tttatggaaa acttcaagaa ttttgagaga agaatcccaa       60

atattcctgc cagttagaca agaaaatgaa acaatacaac ccaaagcaca atgacaatga      120

tgctgcagca aatttactag aagctgtcct gtgaaaaggg tgcttaggag ctctggtctg      180

gaatctgagt cttgctcctg ctctcaccag gcggcttgtc ctaaccctgc atcagtcatt      240

ccctgtgtac agtagggcta ataatccctg tgctttgagg ttctcataag gattaaatta      300

aataagacaa agcaagtgtt tctcaacaa                                        329


<210>  298
<211>  256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  298
gaatggaacg gtggaagagt tggatttgaa gggagaagag aaggctgcct tccttactga       60

gaaaatcaag atttgggagg gtcccagtag caatgtggtc atgagtcttc tgcaagaacc      120

tgaagatggg tgtagggtcg ggggatggga ctgaaaggga aaggagagca tggaacattg      180

ggcagggtga gtagagacaa ccctgtttgc actgcagttc cccctccagc tcaggctgca      240

ttcccagccc taaaac                                                      256


<210>  299
<211>  169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  299
gaaaataaat accttgatga cccaatttgg aaaactactt ctagataagg aaacactatt       60

acccaatatg ttaattttta aaatacccaa agaattgagc aaaaaggact ttggcaaggc      120

aggttgttgg atttaaaacc gttctcccat taatgccaaa gccagcaga                  169


<210>  300
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  300
gaagatagtt ggaggccctc aaacttacct cctcaaggaa atctgggctg gagtttttaa       60

ggggttaatg gagggtgatg gactgaaaaa ttggagtcat agattagtca ggataatgaa      120

gataaaatca gtaggagttg gaaactgcat tctttggtga gtcagctcct tgtggggtcc      180

ttgagagcag ctggcatcag ggaggtccct cagaccagct gagtcagtag tttcatcagt      240

atgctggacc tgaaggaata cctcaaagag aaaaccacat ttcaaaatgt ttaagttatt      300

atctatagaa cagttaagat gaactttaat ctt                                   333


<210>  301
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  301
ttaaatttta cacaataatt gataatttgt atgatatctg aattatacgt caacaaattt       60

acaaaagttt ttgaaccaca tttagctatt ttatctttag ttctgtgtca aagagactgc      120

aggaacatga gcctctcact gctactctta tgcacactat tctgaaatat attacatgag      180

tcaggtgatg agtccatcca agatcattga tattagctga attacagcac ttaaaaatct      240

agggctgggt gcggtggctc acgcctgtaa tcccagcact ttgggaggcc aaggagggca      300

gatcacaagg tcaggggttc gagaccatcc tgccgaatac agtgaa                     346


<210>  302
<211>  295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  302
gaggggtcct gcaacatctc agtctgcgca gctggctgtg ggggtaactc tgtcttaggc       60

caggcagccc tgccttcagt ttccccacct ttcccagggc aggggagagg cctctggcct      120

gacatcatcc acaatgcaaa gaccaaaaca gccgtgacct ccattcacat gggctgagtg      180

ccaactctga gccagggatc tgaggacagc atcgcctcaa gtgacgcagg gactggccgg      240

gcgcagcagc tcacgcctgt aattccagca ctttgggagg ccgaggctgg ctgat           295


<210>  303
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  303
aggctgttgt tacctaggtc cgactcctgg ctcccagagc agcctgtcct gcctgcctgg       60

aactctgagc aggctggagt catggagtcg attcccagaa tcccagagtc agggaggctg      120

ggggcagggg caggtcactg gacaaacaga tcaaaggtga gaccagcgta gggctgcaga      180

ccaggccagg ccagctggac gggcacacca tgaggtaggt gggcgcccac agcctccctg      240

cagggtgtgg ggtgggagca caggcctggg ccctcaccgc ccctgccctg cccataggct      300

gctgaccctc ctgggccttc tgtgtggctc ggtggccacc cccttgggc                  349


<210>  304
<211>  154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  304
acacctgacc ccacagctga gctcgggggc caaggtgctg gccacgctgt gcgggcagga       60

gagcacagac acggagcggg cccctggcaa ggacactttc tactcgctgg gctccagcct      120

ggacattacc ttccgctccg actactccaa cgag                                  154


<210>  305
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (222)..(225)
<223>  Can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (225)..(225)
<223>  Xaa can be Thr or Leu

<220>
<221>  MISC_FEATURE
<222>  (226)..(231)
<223>  Can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (232)..(242)
<223>  Can be present or absent

<400>  305

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Asp Val Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Xaa Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210>  306
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  306

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Lys Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Ser 
    210                 215         


<210>  307
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  307

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Gly Asp Cys Ser Thr Thr Ser Cys Ala Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  308
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  308

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


Leu Val Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu 
            100                 105                 


<210>  309
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  309

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
            100                 105                 110         


Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  310
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  310

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  311
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  311

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  312
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  312

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Asp Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Gly Gly Ser Thr Asn Tyr Gly Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Glu Val Gly Gly Trp Gly Pro Pro Arg Pro Asp Tyr Trp Gly His 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  313
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  313

Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  314
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  314

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ser 
    210                 215                 220     


<210>  315
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  315

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Val Gly Ile Val Val Val Pro Ala Ala Gly Arg Arg 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser 
225                 


<210>  316
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  316

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  317
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  317

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Ser Asn Tyr Tyr 
            20                  25                  30          


Ile His Trp Val Lys Gln Ala Pro Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Tyr Ile Asp Pro Phe Asn Gly Gly Thr Ser Asp Asn Leu Lys Phe Lys 
    50                  55                  60                  


Gly Ala Ala Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Glu Tyr Asp Pro Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  318
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  318

Ile Val Leu Thr Gln Ser Pro Phe Gln Ser Val Ser Pro Lys Glu Lys 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn Leu His 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys Tyr 
        35                  40                  45              


Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp 
65                  70                  75                  80  


Phe Gly Ile Tyr Phe Cys Gln Gln Thr Asn Phe Trp Pro Tyr Ile Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Leu 
            100                 105 


<210>  319
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  319

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ala Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  320
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  320

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  321
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  321

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Tyr Cys Ser Ser Thr Ser Cys His Arg Asp Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  322
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  322

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  323
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  323

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Lys Leu Trp Val Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys 
225     


<210>  324
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  324

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Ala 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  325
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  325

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr His Tyr Val Ser Tyr Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Pro Gly Gly Gln His His His His His His Gly Ala Glu Gln Lys Leu 
    130                 135                 140                 


Ile Ser Glu Glu Asp Leu Ser 
145                 150     


<210>  326
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  326

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Ser Gly Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val 
        195             


<210>  327
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  327

Asp Ile Val Met Thr Gln Thr Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Gly Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Ser 
    210                 


<210>  328
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  328

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Pro Met Tyr Asp Tyr Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Gly Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210>  329
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  329

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Ser 
    210                 215         


<210>  330
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence


<220>
<221>  misc_feature
<222>  (179)..(179)
<223>  Xaa can be any naturally occurring amino acid

<400>  330

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Gly Trp Glu Leu Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Xaa Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His 
225 


<210>  331
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  331

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Glu Gly Ser 
                85                  90                  95      


Asn Asn Phe Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  332
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  332

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ile Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Asp Val Ser Gly Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


<210>  333
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  333

Gln Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  334
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  334

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Thr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala His Val Asp Thr Ala Met Val Glu Ser Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys His 
225         


<210>  335
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  335

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  336
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  336

Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Leu Glu Arg Ala Gly Gly Met Asp Val Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys His 
    210                 215                 220     


<210>  337
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  337

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  338
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  338

Glu Val Gln Leu Glu Glu Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Arg Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Thr Ser Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Glu Gly Ile Pro Gln Leu Leu Arg Thr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro 
    210                 215                 220 


<210>  339
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  339

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Glu Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Val Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn 
    210         


<210>  340
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  340

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Tyr Glu Ala Pro His Tyr Tyr Tyr Tyr Tyr Ala Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  341
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  341

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  342
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  342

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Val 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ile Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Ala Gly Ser Tyr Tyr Tyr Asp Thr Val Gly Pro Gly 
            100                 105                 110         


Leu Pro Glu Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  343
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  343

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  344
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  344

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Gln Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
            100                 105                 110         


Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  345
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  345

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  346
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  346

Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser 
            20                  25                  30          


Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  347
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  347

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Arg 
                85                  90                  95      


Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  348
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  348

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  349
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody sequence

<400>  349

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  350
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  350

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Gly Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Cys Gln Gln Ser Tyr Ser Pro Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 
            100                 105     


<210>  351
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  351

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Asp Ser Met Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asp Arg Glu Ser Ala Thr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Val Ile Ser Arg Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ala Arg Arg Gly Gln Arg Ile Tyr Gly Trp Ser Phe Gly Glu Phe 
            100                 105                 110         


Phe Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  352
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  352

Ser Tyr Val Arg Pro Leu Ser Val Ala Leu Gly Glu Thr Ala Arg Ile 
1               5                   10                  15      


Ser Cys Gly Arg Gln Ala Leu Gly Ser Arg Ala Val Gln Trp Tyr Gln 
            20                  25                  30          


His Arg Pro Gly Gln Ala Pro Ile Leu Leu Ile Tyr Asn Asn Gln Asp 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr Pro Asp Ile Asn 
    50                  55                  60                  


Phe Gly Thr Arg Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Ala Asp Tyr Tyr Cys His Met Trp Asp Ser Arg Ser Gly Phe 
                85                  90                  95      


Ser Trp Ser Phe Gly Gly Ala Thr Arg Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  353
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  353

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Thr Thr Leu Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  354
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  354

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Leu Ser Ser 
            20                  25                  30          


Tyr Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  355
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  355

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Phe Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


<210>  356
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  356

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Gln Ala Asn Gly Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Arg Arg Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Gly Ser 
        35                  40                  45              


Lys Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly Arg Arg Trp Gly 
    50                  55                  60                  


Gln Glu Tyr Asn Leu Thr Ile Asn Asn Leu Gln Pro Glu Asp Ile Ala 
65                  70                  75                  80  


Thr Tyr Phe Cys Gln Val Tyr Glu Phe Val Val Pro Gly Thr Arg Leu 
                85                  90                  95      


Asp Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp 
        


<210>  357
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  357

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser Pro 
        115                 120         


<210>  358
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  358

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  359
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  359

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  360
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  360

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  361
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  361

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Val Ile Ser Ser Asp Ala Asn Asp Lys Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Thr Cys Ser Gly Gly Asn Cys Tyr Ser Gly Leu Ile 
            100                 105                 110         


Asp Tyr Trp Gly Arg Gly Ile Leu Val Thr Val Ser 
        115                 120                 


<210>  362
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  362

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr 
            100                 105                 110 


<210>  363
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  363

Glu Glu Gln Val Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ser Val Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Ser Asp Ser Thr Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Ile Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Tyr Ala Phe Ser Ser Gly Ser Leu Ser Asp 
            100                 105                 110         


Tyr Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  364
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  364

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  365
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  365

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  366
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  366

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Leu Leu Ile Tyr Asp 
        35                  40                  45              


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Glu Phe Leu Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  367
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  367

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ala 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Met Ile Phe Asn Phe Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  368
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  368

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Arg Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  369
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  369

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Met Val Ser Cys Gln Ala Ser Gly Gly Leu Leu Glu Asp Tyr 
            20                  25                  30          


Ile Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Leu Gly Thr Val His Tyr Gly Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Thr Ala Leu Val Val Ser Glu Thr Tyr Leu Pro His Tyr 
            100                 105                 110         


Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250     


<210>  370
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  370

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ala Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Val Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  371
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  371

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Trp Ser Gly Ser Thr Val Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Gln Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Ala Tyr Lys Phe Asn Tyr Tyr Tyr Tyr Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  372
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  372

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Leu Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Leu Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  373
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  373

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Ile Ser Cys Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr 
            20                  25                  30          


Val Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Arg Gly Asp Ile Thr Ile Gly Pro Pro Asn Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ala Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Gly Thr Pro Leu Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Ser 
145                 150                 155                 160 


Ile Ser Cys Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr Val Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Asn Trp Arg Gly Asp Ile Thr Ile Gly Pro Pro Asn Val Glu Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Ala Pro Asp Asp Thr Ala Val Tyr Tyr Cys Gly Ala Gly 
225                 230                 235                 240 


Thr Pro Leu Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser Tyr Asp Tyr 
                245                 250                 255     


Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        275                 280                 285             


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Ile Ser Cys 
    290                 295                 300                 


Ala Ala Ser Gly Gly Ser Leu Ser Asn Tyr Val Leu Gly Trp Phe Arg 
305                 310                 315                 320 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Asn Trp Arg 
                325                 330                 335     


Gly Asp Ile Thr Ile Gly Pro Pro Asn Val Glu Gly Arg Phe Thr Ile 
            340                 345                 350         


Ser Arg Asp Asn Ala Lys Asn Thr Gly Tyr Leu Gln Met Asn Ser Leu 
        355                 360                 365             


Ala Pro Asp Asp Thr Ala Val Tyr Tyr Cys Gly Ala Gly Thr Pro Leu 
    370                 375                 380                 


Asn Pro Gly Ala Tyr Ile Tyr Asp Trp Ser Tyr Asp Tyr Trp Gly Arg 
385                 390                 395                 400 


Gly Thr Gln Val Thr Val Ser Ser 
                405             


<210>  374
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  374

Glu Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile His Phe 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asn Asn Gly Asn Thr Asn Tyr Ala Gln Ser Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ser Thr Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Leu Glu Met Gly His Arg Ser Gly Phe Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Leu Val Thr Val Ser Pro Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp 
225         


<210>  375
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  375

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Thr Cys Gly Gly His Asn Ile Gly Ala Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Gln 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Arg Gly His 
                85                  90                  95      


Pro Leu Tyr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  376
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  376

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Gly Arg His Ser Asp Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210>  377
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  377

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Asn Ile Val His Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Leu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  378
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  378

Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Ser Val Ser Ser 
        115                 


<210>  379
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  379

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val 
            20                  25                  30          


Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105     


<210>  380
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  380

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Trp Phe Gly Glu Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  381
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  381

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  382
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  382

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Met Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Tyr Pro His Ser Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  383
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  383

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  384
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  384

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp His Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Asn Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  385
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  385

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Thr Pro Pro 
                85                  90                  95      


Ile Asn Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  386
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  386

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Arg Met Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Thr Ile Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Val Gly Pro Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Val Ser Arg Glu Asn Ala Lys Asn Ser Leu Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ala Gly Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Ser Asp Arg Gly Val Ala Gly Leu Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Ile Leu Val Thr Val Ser Ser 
        115                 


<210>  387
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  387

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ala Phe Asp Asn Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Ala Leu His Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  388
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  388

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr 
            20                  25                  30          


Thr Val Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asn Leu Asp Asn Ser Gly Thr Tyr Tyr Tyr Phe Ser Gly 
            100                 105                 110         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  389
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  389

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Gly Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Ala Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Asp 
                85                  90                  95      


Tyr Thr Pro Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  390
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  390

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Leu Tyr Asp Gly Ser Asp Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ala Val Ala Gly Thr His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  391
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  391

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  392
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  392

Met Glu Phe Gly Leu Asn Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Val Ser Tyr Asp Gly Arg Thr Lys Asp Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Arg Phe Ser Gly Ala Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


<210>  393
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  393

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Arg Asn 
            100                 105                 110         


Asn Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         


<210>  394
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  394

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Ser Tyr Ser Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val His Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Ile Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Thr Tyr Ser Asp Phe Trp Ser Gly Ser Pro Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  395
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  395

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Val Thr Tyr Phe Cys Gln Gln Tyr Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Lys Val Glu Ile Lys 
            100                 105 


<210>  396
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  396

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asp Arg Gly Gly Ser Arg Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Ala Pro Pro Tyr Asn Tyr Tyr Phe Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  397
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; antibody sequence

<400>  397

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ala Phe 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Gln Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


