                         SEQUENCE LISTING

<110>  REGENXBIO
 
<120>  VECTORIZED LANADELUMAB, LIVER SPECIFIC PROMOTERS, AND 
       ADMINISTRATION THEREOF

<130>  38013.0012P1

<160>  393   

<170>  PatentIn version 3.5

<210>  1
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV7 capsid

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  2
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV8 capsid

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  3
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV9 capsid

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  4
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAVrh10 capsid

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  5
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAVrh46 capsid

<400>  5

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  6
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAVrh73 capsid

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  7
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAVLK03 capsid

<400>  7

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  8
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAVS3 capsid

<400>  8

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  9
<211>  968
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LSPX1 promoter

<400>  9
ggttaatttt taaaaagcag tcaaaagtcc aagtggccct tggcagcatt tactctctct       60

gtttgctctg gttaataatc tcaggagcac aaacattcca gatccaggtt aatttttaaa      120

aagcagtcaa aagtccaagt ggcccttggc agcatttact ctctctgttt gctctggtta      180

ataatctcag gagcacaaac attccagatc cggcgcgcca gggctggaag ctacctttgt      240

ctagaaggct cagaggcaca caggagtttc tgggctcacc ctgccccctt ccaacccctc      300

agttcccatc ctccagcagc tgtttgtgtg ctgcctctga agtccacact gaacaaactt      360

cagcctactc atgtccctaa aatgggcaaa cattgcaagc agcaaacagc aaacacacag      420

ccctccctgc ctgctgacct tggagctggg gcagaggtca gagacctctc tgggcccatg      480

ccacctccaa catccactcg accccttgga atttcggtgg agaggagcag aggttgtcct      540

ggcgtggttt aggtagtgtg agaggggtac ccggggatct tgctaccagt ggaacagcca      600

ctaaggattc tgcagtgaga gcagagggcc agctaagtgg tactctccca gagactgtct      660

gactcacgcc accccctcca ccttggacac aggacgctgt ggtttctgag ccaggtacaa      720

tgactccttt cggtaagtgc agtggaagct gtacactgcc caggcaaagc gtccgggcag      780

cgtaggcggg cgactcagat cccagccagt ggacttagcc cctgtttgct cctccgataa      840

ctggggtgac cttggttaat attcaccagc agcctccccc gttgcccctc tggatccact      900

gcttaaatac ggacgaggac agggccctgt ctcctcagct tcaggcacca ccactgacct      960

gggacagt                                                               968


<210>  10
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LSPX2 promoter

<400>  10
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt                                      1050


<210>  11
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LTP1 promoter

<400>  11
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagt                                                             1089


<210>  12
<211>  1430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LTP2 promoter

<400>  12
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagcc cttaagctag caggttaatt tttaaaaagc      360

agtcaaaagt ccaagtggcc cttggcagca tttactctct ctgtttgctc tggttaataa      420

tctcaggagc acaaacattc cagatccagg ttaattttta aaaagcagtc aaaagtccaa      480

gtggcccttg gcagcattta ctctctctgt ttgctctggt taataatctc aggagcacaa      540

acattccaga tccggcgcgc cagggctgga agctaccttt gacatcattt cctctgcgaa      600

tgcatgtata atttctacag aacctattag aaaggatcac ccagcctctg cttttgtaca      660

actttccctt aaaaaactgc caattccact gctgtttggc ccaatagtga gaactttttc      720

ctgctgcctc ttggtgcttt tgcctatggc ccctattctg cctgctgaag acactcttgc      780

cagcatggac ttaaacccct ccagctctga caatcctctt tctcttttgt tttacatgaa      840

gggtctggca gccaaagcaa tcactcaaag ttcaaacctt atcatttttt gctttgttcc      900

tcttggcctt ggttttgtac atcagctttg aaaataccat cccagggtta atgctggggt      960

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag     1020

atgttgcttt ctgagaggat cttgctacca gtggaacagc cactaaggat tctgcagtga     1080

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1140

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1200

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1260

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1320

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1380

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1430


<210>  13
<211>  1318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LTP3 promter

<400>  13
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagta aaacaggtaa gtccgctgtt tgtgtgctgc ctctgaagtc cacactgaac     1140

aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac     1200

acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggc     1260

ctctactaac catgttcatg ttttcttttt ttttctacag gtcctgggtg acgaacag       1318


<210>  14
<211>  1579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP6 promoter

<400>  14
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagt                                                  1579


<210>  15
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP13 promoter

<400>  15
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtctaga ggccgtccgc      360

cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg tggggagtta      420

tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa aaataactcc      480

cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac ggttcctcac      540

ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg gccgggcggt      600

gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag ctacccggag      660

gagcgggagg cgccaagcgt gagtatcgat cttgctacca gtggaacagc cactaaggat      720

tctgcagtga gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg      780

ccaccccctc caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct      840

ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg      900

ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg      960

accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat     1020

acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt     1080


<210>  16
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP14 promoter

<400>  16
gaatggtgga cacccaaata tggcgacggt tcctcacccg tcgccatatt tgggtgtccg       60

ccctcggccg gggccgcatt cctgggggcc gggcggtgct cccgcccgcc tcgataaaag      120

gctccggggc cggcggcggc ccacgagcta cccggaggag cgggaggcgc caagcgatct      180

tgctaccagt ggaacagcca ctaaggattc tgcagtgaga gcagagggcc agctaagtgg      240

tactctccca gagactgtct gactcacgcc accccctcca ccttggacac aggacgctgt      300

ggtttctgag ccaggtacag tgactccttt cggtaagtgc agtggaagct gtacactgcc      360

caggcaaagc gtccgggcag cgtaggcggg cgactcagat cccagccagt ggacttagcc      420

cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc agcctccccc      480

gttgcccctc tggatccact gcttaaatac ggacgaggac agggccctgt ctcctcagct      540

tcaggcacca ccactgacct gggacagt                                         568


<210>  17
<211>  895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP15 promoter

<400>  17
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagaa tggtggacac ccaaatatgg cgacggttcc      360

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg      420

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc      480

ggaggagcgg gaggcgccaa gcgatcttgc taccagtgga acagccacta aggattctgc      540

agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac tcacgccacc      600

ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacagtga ctcctttcgg      660

taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt aggcgggcga      720

ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg gggtgacctt      780

ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct taaatacgga      840

cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg acagt           895


<210>  18
<211>  1291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP18 promoter

<400>  18
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccctg catgcgaaga      480

tcttcgaaca aggctgtggg ggactgaggg caggctgtaa caggcttggg ggccagggct      540

tatacgtgcc tgggactccc aaagtattac tgttccatgt tcccggcgaa gggccagctg      600

tcccccgcca gctagactca gcacttagtt taggaaccag tgagcaagtc agcccttggg      660

gcagcccata caaggccatg gggctgggca agctgcacgc ctgggtccgg ggtgggcacg      720

gtgcccgggc aacgagctga aagctcatct gctctcaggg gcccctccct ggggacagcc      780

cctcctggct agtcacaccc tgtaggctcc tctatataac ccaggggcac aggggctgcc      840

ctcattctac caccacctcc acagcacaga cagacactca ggagccagcc agcgtcgaga      900

tcttgctacc agtggaacag ccactaagga ttctgcagtg agagcagagg gccagctaag      960

tggtactctc ccagagactg tctgactcac gccaccccct ccaccttgga cacaggacgc     1020

tgtggtttct gagccaggta cagtgactcc tttcggtaag tgcagtggaa gctgtacact     1080

gcccaggcaa agcgtccggg cagcgtaggc gggcgactca gatcccagcc agtggactta     1140

gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc agcagcctcc     1200

cccgttgccc ctctggatcc actgcttaaa tacggacgag gacagggccc tgtctcctca     1260

gcttcaggca ccaccactga cctgggacag t                                    1291


<210>  19
<211>  1147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP19 promoter

<400>  19
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccctgcatg cgaagatctt cgaacaaggc tgtgggggac      360

tgagggcagg ctgtaacagg cttgggggcc agggcttata cgtgcctggg actcccaaag      420

tattactgtt ccatgttccc ggcgaagggc cagctgtccc ccgccagcta gactcagcac      480

ttagtttagg aaccagtgag caagtcagcc cttggggcag cccatacaag gccatggggc      540

tgggcaagct gcacgcctgg gtccggggtg ggcacggtgc ccgggcaacg agctgaaagc      600

tcatctgctc tcaggggccc ctccctgggg acagcccctc ctggctagtc acaccctgta      660

ggctcctcta tataacccag gggcacaggg gctgccctca ttctaccacc acctccacag      720

cacagacaga cactcaggag ccagccagcg tcgagatctt gctaccagtg gaacagccac      780

taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg      840

actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacagt      900

gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc      960

gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac     1020

tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg     1080

cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg     1140

ggacagt                                                               1147


<210>  20
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; LMTP20 promoter

<400>  20
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gcccttcaga ttaaaaataa ctgaggtaag ggcctgggta      360

ggggaggtgg tgtgagacgc tcctgtctct cctctatctg cccatcggcc ctttggggag      420

gaggaatgtg cccaaggact aaaaaaaggc catggagcca gaggggcgag ggcaacagac      480

ctttcatggg caaaccttgg ggccctgctg aagctttggc ccactacggg tttaggctgc      540

ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt aacccagaca      600

tgtggctgcc cccccccccc ccaacacctg ctgcctctaa aaataaccct gtccctggtg      660

gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg gactgagggc aggctgtaac      720

aggcttgggg gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt      780

cccggcgaag ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt      840

gagcaagtca gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc      900

tgggtccggg gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg      960

cccctccctg gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc     1020

caggggcaca ggggctgccc tcattctacc accacctcca cagcacagac agacactcag     1080

gagccagcca gcgtcgagat cttgctacca gtggaacagc cactaaggat tctgcagtga     1140

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1200

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1260

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1320

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1380

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1440

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1490


<210>  21
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; ApoE.hAAT promoter

<400>  21
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<400>  22

Arg Xaa Lys Arg 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<400>  23

Arg Xaa Arg Arg 
1               


<210>  24
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; rh64R1 capsid

<400>  24

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  25
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; lanadelumab Fc domain

<400>  25

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 


<210>  26
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Alpha-Mic/Bik Enhancer

<400>  26
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc                            100


<210>  27
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Tandem (2) alpha-Mic/Bik Enhancers

<400>  27
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc aggttaattt ttaaaaagca      120

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      180

ctcaggagca caaacattcc                                                  200


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; ApoE Hepatic Control Region containing ApoE 
       Enhancer

<400>  28
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  29
<211>  554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Tandem (2) ApoE Enhancers

<400>  29
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctg                                                        554


<210>  30
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hAAT Promoter

<400>  30
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  31
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hAAT(?ATG) Promoter

<400>  31
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  32
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Mck Enhancer

<400>  32
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatc                                             144


<210>  33
<211>  288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Tandem (2) Mck Enhancers

<400>  33
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatc                   288


<210>  34
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Tandem Mck (3) Enhancers

<400>  34
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tc                                                          432


<210>  35
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Myosin heavy chain enhancer

<400>  35
cccttcagat taaaaataac tgaggtaagg gcctgggtag gggaggtggt gtgagacgct       60

cctgtctctc ctctatctgc ccatcggccc tttggggagg aggaatgtgc ccaaggacta      120

aaaaaaggcc atggagccag aggggcgagg gcaacagacc tttcatgggc aaaccttggg      180

gccctgctga agctttggc                                                   199


<210>  36
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; CAG/CB7

<400>  36
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaag                     1725


<210>  37
<211>  865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; CK8 promoter

<400>  37
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tcccctgcat gcgaagatct tcgaacaagg ctgtggggga ctgagggcag      480

gctgtaacag gcttgggggc cagggcttat acgtgcctgg gactcccaaa gtattactgt      540

tccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca cttagtttag      600

gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg ctgggcaagc      660

tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag ctcatctgct      720

ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct      780

atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca gcacagacag      840

acactcagga gccagccagc gtcga                                            865


<210>  38
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mU1a

<400>  38
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210>  39
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; EF-1alpha

<400>  39
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  40
<211>  460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; TBG

<400>  40
gggctggaag ctacctttga catcatttcc tctgcgaatg catgtataat ttctacagaa       60

cctattagaa aggatcaccc agcctctgct tttgtacaac tttcccttaa aaaactgcca      120

attccactgc tgtttggccc aatagtgaga actttttcct gctgcctctt ggtgcttttg      180

cctatggccc ctattctgcc tgctgaagac actcttgcca gcatggactt aaacccctcc      240

agctctgaca atcctctttc tcttttgttt tacatgaagg gtctggcagc caaagcaatc      300

actcaaagtt caaaccttat cattttttgc tttgttcctc ttggccttgg ttttgtacat      360

cagctttgaa aataccatcc cagggttaat gctggggtta atttataact aagagtgctc      420

tagttttgca atacaggaca tgctataaaa atggaaagat                            460


<210>  41
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; chimeric intron

<400>  41
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  42
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; VH4 intron

<400>  42
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc ccagggctca       60

ctgtgggtct ctctgttcac ag                                                82


<210>  43
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; SV40 intron

<400>  43
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  44
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; beta-globin PolyA signal

<400>  44
ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctca            55


<210>  45
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Rabbit beta-globin polyA

<400>  45
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  46
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; 5'ITR

<400>  46
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  47
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; 5'-ITR

<400>  47
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  48
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; 3'-ITR AAV

<400>  48
gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caa                                              143


<210>  49
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; 3'-ITR

<400>  49
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                 110


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Mutant interleukin 2 signal peptide

<400>  50

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Mutant interleukin 2 signal peptide coding 
       sequence

<400>  51
atgtatagga tgcaactgct cctcctgatt gctctgagcc tggctcttgt gaccaactct       60


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Serum albumin

<400>  52

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  53
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human alpha-1 Antitrypsin

<400>  53

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Apolipoprotein A-1

<400>  54

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala 
        


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Apolipoprotein A-2

<400>  55

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly 
        


<210>  56
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Apolipoprotein B-100

<400>  56

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala 
            20                  25          


<210>  57
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Coagulation Factor IX

<400>  57

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Complement C2

<400>  58

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser 
            20  


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Complement Factor H-related Protein 2

<400>  59

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly 
        


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Complement Factor H-related Protein 5

<400>  60

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly 
        


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Fibrinogen alpha-chain

<400>  61

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr 
            


<210>  62
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Fibrinogen beta-chain

<400>  62

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser 
            20                  25                  30  


<210>  63
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct;

<400>  63

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala 
            20                  25      


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human ?-2-HS-Glycoprotein

<400>  64

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser 
        


<210>  65
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Hemopexin

<400>  65

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala 
            20              


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Kininogen-1

<400>  66

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr 
        


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Mannose-binding protein C

<400>  67

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser 
            20  


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct;

<400>  68

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  69
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Prothrombin

<400>  69

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser 
            20                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Secreted Phosphoprotein 24

<400>  70

Met Ile Ser Arg Met Glu Lys Met Thr Met Met Met Lys Ile Leu Ile 
1               5                   10                  15      


Met Phe Ala Leu Gly Met Asn Tyr Trp Ser Cys Ser Gly 
            20                  25                  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Anti-thrombin-III

<400>  71

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Serotransferrin

<400>  72

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human SPARC

<400>  73

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  74
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Collagen alpha-1(I) chain

<400>  74

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly 
            20          


<210>  75
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Lactotransferrin

<400>  75

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  76
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Complement C3

<400>  76

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly 
            20          


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Lumican

<400>  77

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly 
        


<210>  78
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Gelsolin isoform 1

<400>  78

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala 
            20                  25          


<210>  79
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Pro-cathepsin H

<400>  79

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala 
            20          


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human SERPINF1

<400>  80

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys 
            


<210>  81
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human SERPINE1

<400>  81

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala 
            20              


<210>  82
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Cathepsin D

<400>  82

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala 
            20  


<210>  83
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human TIMP1

<400>  83

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala 
            20              


<210>  84
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Fibronectin

<400>  84

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg 
            20                  25                  30      


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Complement C1s subcomponent

<400>  85

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala 
1               5                   10                  15  


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct;

<400>  86

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Cathepsin B

<400>  87

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala 
    


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Salivary acidic proline-rich 
       phosphoprotein

<400>  88

Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala 
1               5                   10                  15      


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Human Follistatin-related protein 1

<400>  89

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala 
            20  


<210>  90
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  90

Gly Ser Gly 
1           


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; furin linker

<400>  91

Arg Lys Arg Arg 
1               


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  92

Arg Arg Arg Arg 
1               


<210>  93
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  93

Arg Arg Lys Arg 
1               


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  94

Arg Lys Lys Arg 
1               


<210>  95
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  95

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  96
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  96

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  97
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  97

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  98
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  98

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  99
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  99

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  100
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  100

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  101
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  101

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  102
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  102

Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
1               5                   10                  15      


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25          


<210>  103
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  103

Arg Lys Arg Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  104
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct;

<400>  104

Arg Lys Arg Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210>  105
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  105

Arg Lys Arg Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
1               5                   10                  15      


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25              


<210>  106
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  106

Arg Lys Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe 
1               5                   10                  15      


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25                  30      


<210>  107
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  107
agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg ggatgttgaa       60

gagaatcctg ggcct                                                        75


<210>  108
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  108
agaaagagaa ga                                                           12


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  109
agaaagagaa gaggctctgg a                                                 21


<210>  110
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  110
ggctctgga                                                                9


<210>  111
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  111

Gly Ala Ala Gly Gly Cys Ala Gly Ala Gly Gly Cys Thr Cys Cys Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Ala Cys Ala Thr Gly Thr Gly Gly Gly Gly Ala 
            20                  25                  30          


Thr Gly Thr Thr Gly Ala Ala Gly Ala Gly Ala Ala Thr Cys Cys Thr 
        35                  40                  45              


Gly Gly Gly Cys Cys Thr 
    50                  


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  112

Cys Pro Pro Cys Pro 
1               5   


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  113

Cys Pro Pro Cys Pro Ala 
1               5       


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  114

Cys Pro Pro Cys Ala 
1               5   


<210>  115
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  115

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  116
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  116

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  117

Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  118

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  119

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  120

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  121
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  121

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  122
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  122

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  123
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  123

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210>  124
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  124

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  125
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  125

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  126

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  127
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  127

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  128
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  128

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  129

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  130

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
1               5                   10              


<210>  131
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  131

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  132
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct;

<400>  132

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  133
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  133

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  134

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  135
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  135

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210>  136
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  136

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  137
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  137

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  138
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  138

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210>  139
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  139

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  140
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; hinge region

<400>  140

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  141
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; IgG1

<400>  141

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  142
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; IgG2

<400>  142

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  143
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; IgG4

<400>  143

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  144
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab Heavy


<220>
<221>  MISC_FEATURE
<222>  (227)..(230)
<223>  wherein amino acids 227 to 230 are either present or absent

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  wherein Xaa is K

<220>
<221>  MISC_FEATURE
<222>  (228)..(228)
<223>  wherein Xaa is T

<220>
<221>  MISC_FEATURE
<222>  (229)..(229)
<223>  wherein Xaa is H

<220>
<221>  MISC_FEATURE
<222>  (230)..(230)
<223>  wherein Xaa is T or L

<220>
<221>  MISC_FEATURE
<222>  (231)..(236)
<223>  wherein amino acids 231 to 236 are either present or absent

<220>
<221>  MISC_FEATURE
<222>  (237)..(247)
<223>  wherein amino acids 237 to 247 are either present or absent

<400>  144

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Ser Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Arg Arg Ile Gly Val Pro Arg Arg Asp Glu Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Xaa Xaa Xaa Xaa Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210>  145
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab Light

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  146
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab Heavy


<220>
<221>  MISC_FEATURE
<222>  (678)..(690)
<223>  wherein amino acids 678 to 690 are present or absent

<220>
<221>  MISC_FEATURE
<222>  (688)..(688)
<223>  wherein Xaa is A or C

<220>
<221>  MISC_FEATURE
<222>  (689)..(689)
<223>  wherein Xaa is C or T

<220>
<221>  MISC_FEATURE
<222>  (690)..(690)
<223>  wherein Xaa is C or G

<220>
<221>  MISC_FEATURE
<222>  (691)..(708)
<223>  wherein amino acids 691 to 708 are present or absent

<220>
<221>  MISC_FEATURE
<222>  (709)..(736)
<223>  wherein amino acids 709 to 736 are present or absent

<400>  146

Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly Gly 
1               5                   10                  15      


Ala Gly Ala Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Cys Ala Gly Cys Cys Cys Gly Gly Cys Gly Gly Cys 
        35                  40                  45              


Ala Gly Cys Cys Thr Gly Ala Gly Gly Cys Thr Gly Ala Gly Cys Thr 
    50                  55                  60                  


Gly Cys Gly Cys Cys Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Gly Cys Cys Ala Cys Thr Ala Cys 
                85                  90                  95      


Ala Thr Cys Ala Thr Gly Ala Thr Gly Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Cys Cys Cys Cys Cys Gly Gly Cys Ala Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ala Gly Cys Gly Gly Cys Ala Thr Cys Thr Ala Cys Ala Gly Cys Ala 
145                 150                 155                 160 


Gly Cys Gly Gly Cys Gly Gly Cys Ala Thr Cys Ala Cys Cys Gly Thr 
                165                 170                 175     


Gly Thr Ala Cys Gly Cys Cys Gly Ala Cys Ala Gly Cys Gly Thr Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Ala Gly Gly Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Ala Gly Cys Ala Gly Gly Gly Ala Cys Ala Ala Cys Ala Gly 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Cys Cys Cys Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys 
        275                 280                 285             


Gly Cys Cys Thr Ala Cys Ala Gly Gly Ala Gly Gly Ala Thr Cys Gly 
    290                 295                 300                 


Gly Cys Gly Thr Gly Cys Cys Cys Ala Gly Gly Ala Gly Gly Gly Ala 
305                 310                 315                 320 


Cys Gly Ala Gly Thr Thr Cys Gly Ala Cys Ala Thr Cys Thr Gly Gly 
                325                 330                 335     


Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Thr Gly Gly 
            340                 345                 350         


Thr Gly Ala Cys Cys Gly Thr Gly Ala Gly Cys Ala Gly Cys Gly Cys 
        355                 360                 365             


Cys Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Cys 
    370                 375                 380                 


Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly 
385                 390                 395                 400 


Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly Cys Ala Ala Gly Ala Gly 
                405                 410                 415     


Cys Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly Gly Cys Ala Cys Cys 
            420                 425                 430         


Gly Cys Cys Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys 
        435                 440                 445             


Thr Gly Gly Thr Gly Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr 
    450                 455                 460                 


Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Cys 
465                 470                 475                 480 


Gly Thr Gly Ala Gly Cys Thr Gly Gly Ala Ala Cys Ala Gly Cys Gly 
                485                 490                 495     


Gly Cys Gly Cys Cys Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly 
            500                 505                 510         


Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Cys 
        515                 520                 525             


Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala Gly Ala Gly Cys Ala 
    530                 535                 540                 


Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys Cys Thr 
545                 550                 555                 560 


Gly Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys 
                565                 570                 575     


Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Gly Cys Ala Gly Cys Cys 
            580                 585                 590         


Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala 
        595                 600                 605             


Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Cys 
    610                 615                 620                 


Cys Ala Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala 
625                 630                 635                 640 


Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly 
                645                 650                 655     


Gly Gly Thr Gly Gly Ala Gly Cys Cys Cys Ala Ala Gly Ala Gly Cys 
            660                 665                 670         


Thr Gly Cys Gly Ala Cys Ala Ala Gly Ala Cys Cys Cys Ala Cys Xaa 
        675                 680                 685             


Xaa Xaa Thr Gly Cys Cys Cys Cys Cys Cys Cys Thr Gly Cys Cys Cys 
    690                 695                 700                 


Cys Gly Cys Cys Cys Cys Cys Gly Ala Gly Cys Thr Gly Cys Thr Gly 
705                 710                 715                 720 


Gly Gly Cys Gly Gly Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Thr 
                725                 730                 735     


Thr Cys Cys Thr Gly 
            740     


<210>  147
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab Light

<400>  147

Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Ala Gly Cys Cys Cys Cys Ala Gly Cys Ala Cys Cys Cys Thr 
            20                  25                  30          


Gly Ala Gly Cys Gly Cys Cys Ala Gly Cys Gly Thr Gly Gly Gly Cys 
        35                  40                  45              


Gly Ala Cys Ala Gly Gly Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Cys Ala 
65                  70                  75                  80  


Gly Ala Gly Cys Ala Thr Cys Ala Gly Cys Ala Gly Cys Thr Gly Gly 
                85                  90                  95      


Cys Thr Gly Gly Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys 
            100                 105                 110         


Ala Gly Ala Ala Gly Cys Cys Cys Gly Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Cys Cys Cys Cys Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys 
    130                 135                 140                 


Thr Ala Cys Ala Ala Gly Gly Cys Cys Ala Gly Cys Ala Cys Cys Cys 
145                 150                 155                 160 


Thr Gly Gly Ala Gly Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys Cys 
                165                 170                 175     


Cys Ala Gly Cys Ala Gly Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys 
            180                 185                 190         


Ala Gly Cys Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Cys Cys Gly 
        195                 200                 205             


Ala Gly Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr 
    210                 215                 220                 


Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys Cys Cys 
225                 230                 235                 240 


Gly Ala Cys Gly Ala Cys Thr Thr Cys Gly Cys Cys Ala Cys Cys Thr 
                245                 250                 255     


Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Ala 
            260                 265                 270         


Cys Ala Ala Cys Ala Cys Cys Thr Ala Cys Thr Gly Gly Ala Cys Cys 
        275                 280                 285             


Thr Thr Cys Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala 
    290                 295                 300                 


Ala Gly Gly Thr Gly Gly Ala Gly Ala Thr Cys Ala Ala Gly Ala Gly 
305                 310                 315                 320 


Gly Ala Cys Cys Gly Thr Gly Gly Cys Cys Gly Cys Cys Cys Cys Cys 
                325                 330                 335     


Ala Gly Cys Gly Thr Gly Thr Thr Cys Ala Thr Cys Thr Thr Cys Cys 
            340                 345                 350         


Cys Cys Cys Cys Cys Ala Gly Cys Gly Ala Cys Gly Ala Gly Cys Ala 
        355                 360                 365             


Gly Cys Thr Gly Ala Ala Gly Ala Gly Cys Gly Gly Cys Ala Cys Cys 
    370                 375                 380                 


Gly Cys Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Thr Gly Cys Cys 
385                 390                 395                 400 


Thr Gly Cys Thr Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala 
                405                 410                 415     


Cys Cys Cys Cys Ala Gly Gly Gly Ala Gly Gly Cys Cys Ala Ala Gly 
            420                 425                 430         


Gly Thr Gly Cys Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly 
        435                 440                 445             


Ala Cys Ala Ala Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Ala Gly 
    450                 455                 460                 


Cys Gly Gly Cys Ala Ala Cys Ala Gly Cys Cys Ala Gly Gly Ala Gly 
465                 470                 475                 480 


Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly 
                485                 490                 495     


Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys Ala Gly Cys Ala Cys 
            500                 505                 510         


Cys Thr Ala Cys Ala Gly Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys 
        515                 520                 525             


Ala Cys Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly Ala Gly Cys Ala 
    530                 535                 540                 


Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala 
545                 550                 555                 560 


Gly Cys Ala Cys Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly Cys Cys 
                565                 570                 575     


Thr Gly Cys Gly Ala Gly Gly Thr Gly Ala Cys Cys Cys Ala Cys Cys 
            580                 585                 590         


Ala Gly Gly Gly Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Cys Cys 
        595                 600                 605             


Cys Gly Thr Gly Ala Cys Cys Ala Ala Gly Ala Gly Cys Thr Thr Cys 
    610                 615                 620                 


Ala Ala Cys Ala Gly Gly Gly Gly Cys Gly Ala Gly Thr Gly Cys 
625                 630                 635                 


<210>  148
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; L01

<400>  148
atgtaccgga tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaatagc       60

gaagtccagc tgctggaatc tggcggcgga cttgttcaac ctggcggctc tctgagactg      120

agctgtgccg cttccggctt caccttcagc cactatatca tgatgtgggt ccgacaggcc      180

cctggcaaag gccttgaatg ggtgtccggc atctatagca gcggcggcat cacagtgtac      240

gccgactctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      300

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcgc ctatagaaga      360

atcggcgtgc ccagacggga cgagttcgat atttggggcc agggcaccat ggtcaccgtg      420

tctagcgcct ctacaaaggg ccctagcgtg ttccctctgg ctcctagcag caagagcaca      480

agcggaggaa cagccgctct gggctgtctg gtcaaggact actttcccga gcctgtgacc      540

gtgtcctgga atagcggagc actgacaagc ggcgtgcaca cctttccagc tgtgctgcaa      600

agcagcggcc tgtactctct gagcagcgtg gtcacagtgc caagctctag cctgggcacc      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgcgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctc      780

ggcggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgcgt ggtggtggat gtgtcccacg aggatcccga agtgaagttc      900

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat cgagaaaacc     1080

atcagcaagg ccaagggcca gcctagggaa ccccaggttt acacactgcc tccaagccgg     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctcg tgaagggctt ctacccttcc     1200

gatatcgccg tggaatggga gagcaatggc cagccagaga acaactacaa gacaacccct     1260

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgacagt ggacaagtcc     1320

agatggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagtctgag cctgtctcca ggcctgcgga agagaagggc tcctgtgaag     1440

cagaccctga acttcgacct gctgaaactg gccggcgacg tggaaagcaa ccccggacct     1500

atgtatagaa tgcagctcct cctgctgatc gcactgagcc tggctctcgt gaccaacagc     1560

gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc     1620

atcacctgta gagccagcca gtccatctcc tcttggctgg cctggtatca gcaaaagcct     1680

ggcaaggccc ctaagctgct gatctacaag gcctccacac tggaaagcgg ggtgccctcc     1740

agattttctg gcagcggatc tggcaccgag ttcaccctga ccatcagtag cctgcagcct     1800

gacgacttcg ccacctacta ctgccagcag tacaatacct actggacctt cggccaggga     1860

acaaaggtgg aaatcaagcg gactgtggcc gctccaagcg tgttcatctt tccacctagc     1920

gacgagcagc tgaagtccgg cacagcctct gttgtgtgcc tgctgaacaa cttctacccc     1980

agagaagcca aggtgcagtg gaaagtggac aatgccctgc agagcggcaa ctcccaagag     2040

agcgtgacag agcaggactc caaggattcc acctacagcc tgtctagcac cctgacactg     2100

agcaaggccg actacgagaa gcacaaagtg tatgcctgcg aagtgaccca ccagggcctt     2160

agctctccag tgaccaagag cttcaaccgg ggcgagtgtt gataa                     2205


<210>  149
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; L02

<400>  149
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      180

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      240

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      360

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagagcacc      480

agtggtggaa cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggggc tctgacttct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcaca      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcagaaaga gaagaggctc tggagaaggc     1440

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     1500

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     1560

acacagagcc cctccacact gtctgcatct gtgggagaca gagtgaccat cacctgtaga     1620

gccagccagt ctatctctag ctggctggcc tggtatcagc aaaagcctgg caaggcccct     1680

aagctgctga tctacaaggc cagcacactt gagtcagggg tgccctccag attttctggc     1740

tctggatctg gcacagagtt caccctgacc atcagctccc tgcagccaga tgactttgcc     1800

acctactact gccagcagta caatacctac tggacctttg gccagggaac aaaggtggaa     1860

atcaagagaa cagtggctgc cccatctgtg ttcatcttcc caccatctga tgaacagctg     1920

aagtctggca ctgcctctgt tgtgtgcctg ctgaacaact tttaccccag agaagccaag     1980

gtgcagtgga aagtggataa tgccctgcag tctggcaata gccaagaatc tgtgacagag     2040

caggactcca aggattccac ctacagcctg agcagcaccc tgacactgag caaggctgac     2100

tatgagaagc acaaagtgta tgcctgtgaa gtgacacacc agggactgag cagcccagtg     2160

accaagagct tcaacagggg agagtgctga taa                                  2193


<210>  150
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; L03

<400>  150
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      180

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      240

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      360

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      420

tcctctgcca gcacaaaggg cccctctgtt tttccactgg ctcccagcag caagagcacc      480

agtggtggaa cagctgccct gggctgtctg gtcaaggatt acttccctga gcctgtgact      540

gtgtcctgga actctggggc tctgacctct ggggtgcaca cctttccagc tgtgctgcag      600

tcctctggcc tgtactctct gtcctctgtg gtcacagtgc ctagctctag cctgggcaca      660

cagacctaca tctgcaatgt gaaccacaag cctagcaaca ccaaggtgga caagagagtg      720

gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt      780

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      840

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      900

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      960

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat     1020

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc     1080

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga     1140

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct     1200

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct     1260

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc     1320

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     1380

tacacccaga aaagtctgtc tctgtcccct ggcagaaaga gaagaggatc aggggcccca     1440

gtgaagcaga ccctgaactt tgatctgctg aagctggctg gggatgttga gagcaaccct     1500

ggacctatgt ataggatgca actgctcctc ctgattgctc tgagcctggc tcttgtgacc     1560

aactctgaca tccagatgac acagagcccc tccacactgt ctgcatctgt gggagacaga     1620

gtgaccatca cctgtagagc cagccagtct atctcttcct ggctggcctg gtatcagcaa     1680

aagcctggca aggcccctaa gctgctgatc tacaaggcca gcacacttga gtcaggggtg     1740

ccctccagat tttctggctc tggatctggc acagagttca ccctgaccat cagctccctg     1800

cagccagatg actttgccac ctactactgc cagcagtaca atacctactg gacctttggc     1860

cagggaacaa aggtggaaat caagagaaca gtggctgccc catctgtgtt catcttccca     1920

ccatctgatg aacagctgaa gtctggcact gcctctgttg tgtgcctgct gaacaacttt     1980

taccctagag aagccaaggt gcagtggaaa gtggataatg ccctgcagtc tggcaatagc     2040

caagaatctg tgacagagca ggactccaag gattccacct acagcctgag cagcaccctg     2100

acactgagca aggctgacta tgagaagcac aaagtgtatg cctgtgaagt gacacaccag     2160

ggactgagca gcccagtgac caagagcttc aacaggggag agtgctgata a              2211


<210>  151
<211>  4196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; CAG.LAN.F2A

<400>  151
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgcta     1740

gcgggcactt tgcactggaa cttacaacac ccgagcaagg acgcgactct ccaccatgta     1800

ccggatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca atagcgaagt     1860

ccagctgctg gaatctggcg gcggacttgt tcaacctggc ggctctctga gactgagctg     1920

tgccgcttcc ggcttcacct tcagccacta tatcatgatg tgggtccgac aggcccctgg     1980

caaaggcctt gaatgggtgt ccggcatcta tagcagcggc ggcatcacag tgtacgccga     2040

ctctgtgaag ggcagattca ccatcagccg ggacaacagc aagaacaccc tgtacctgca     2100

gatgaacagc ctgagagccg aggacaccgc cgtgtactac tgcgcctata gaagaatcgg     2160

cgtgcccaga cgggacgagt tcgatatttg gggccagggc accatggtca ccgtgtctag     2220

cgcctctaca aagggcccta gcgtgttccc tctggctcct agcagcaaga gcacaagcgg     2280

aggaacagcc gctctgggct gtctggtcaa ggactacttt cccgagcctg tgaccgtgtc     2340

ctggaatagc ggagcactga caagcggcgt gcacaccttt ccagctgtgc tgcaaagcag     2400

cggcctgtac tctctgagca gcgtggtcac agtgccaagc tctagcctgg gcacccagac     2460

ctacatctgc aatgtgaacc acaagcctag caacaccaag gtggacaaga gagtggaacc     2520

caagagctgc gacaagaccc acacctgtcc tccatgtcct gctccagaac tgctcggcgg     2580

accttccgtg ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc     2640

tgaagtgacc tgcgtggtgg tggatgtgtc ccacgaggat cccgaagtga agttcaattg     2700

gtacgtggac ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa     2760

cagcacctac agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa     2820

agagtacaag tgcaaggtgt ccaacaaggc cctgcctgct cctatcgaga aaaccatcag     2880

caaggccaag ggccagccta gggaacccca ggtttacaca ctgcctccaa gccgggaaga     2940

gatgaccaag aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat     3000

cgccgtggaa tgggagagca atggccagcc agagaacaac tacaagacaa cccctcctgt     3060

gctggacagc gacggctcat tcttcctgta cagcaagctg acagtggaca agtccagatg     3120

gcagcagggc aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac     3180

ccagaagagt ctgagcctgt ctccaggcct gcggaagaga agggctcctg tgaagcagac     3240

cctgaacttc gacctgctga aactggccgg cgacgtggaa agcaaccccg gacctatgta     3300

tagaatgcag ctcctcctgc tgatcgcact gagcctggct ctcgtgacca acagcgacat     3360

ccagatgaca cagagcccca gcacactgtc tgccagcgtg ggagacagag tgaccatcac     3420

ctgtagagcc agccagtcca tctcctcttg gctggcctgg tatcagcaaa agcctggcaa     3480

ggcccctaag ctgctgatct acaaggcctc cacactggaa agcggggtgc cctccagatt     3540

ttctggcagc ggatctggca ccgagttcac cctgaccatc agtagcctgc agcctgacga     3600

cttcgccacc tactactgcc agcagtacaa tacctactgg accttcggcc agggaacaaa     3660

ggtggaaatc aagcggactg tggccgctcc aagcgtgttc atctttccac ctagcgacga     3720

gcagctgaag tccggcacag cctctgttgt gtgcctgctg aacaacttct accccagaga     3780

agccaaggtg cagtggaaag tggacaatgc cctgcagagc ggcaactccc aagagagcgt     3840

gacagagcag gactccaagg attccaccta cagcctgtct agcaccctga cactgagcaa     3900

ggccgactac gagaagcaca aagtgtatgc ctgcgaagtg acccaccagg gccttagctc     3960

tccagtgacc aagagcttca accggggcga gtgttgataa agcggccgcg gtacctctag     4020

agtcgacccg ggcggcctcg aggacggggt gaactacgcc tgaggatccg atctttttcc     4080

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     4140

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcg         4196


<210>  152
<211>  4106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; CAG.LANv2.F2A

<400>  152
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccgccacca     1740

tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc accaattctg     1800

aggtccagct gcttgagagt ggtggtggac tggttcagcc tggtggcagc ctgagactgt     1860

cttgtgctgc ctctggcttc accttcagcc actatatcat gatgtgggtc agacaggccc     1920

ctggcaaagg cctggaatgg gtgtcaggca tctacagcag tggtggcatc acagtgtatg     1980

ctgactctgt gaagggcaga ttcaccatca gcagagacaa cagcaagaac accctgtacc     2040

tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc tatagaagaa     2100

ttggggtgcc cagaagggat gagtttgaca tctggggcca gggcaccatg gttacagtgt     2160

cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc aagagcacca     2220

gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag cctgtgactg     2280

tgtcctggaa ctctggggct ctgacctctg gggtgcacac ctttccagct gtgctgcagt     2340

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc ctgggcacac     2400

agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagagagtgg     2460

aacccaagag ctgtgacaag acccacacct gtcctccatg tcctgctcca gaactgcttg     2520

gaggcccttc tgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa     2580

cccctgaagt gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca     2640

attggtatgt ggatggggtt gaagtgcaca atgccaagac caagcctaga gaggaacagt     2700

acaacagcac ctacagagtg gtttctgtgc tgacagtgct gcaccaggac tggctgaatg     2760

gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gagaaaacca     2820

tctccaaggc caagggccag ccaagagaac cccaggttta caccctgcca cctagcagag     2880

aagagatgac caagaaccag gtgtccctga cctgcctggt taagggcttc tacccctctg     2940

acattgctgt ggaatgggag agcaatggcc agcctgaaaa caactacaag acaacccctc     3000

ctgtgctgga ctctgatggc tcattcttcc tgtacagcaa gctgactgtg gacaagtcca     3060

gatggcagca gggaaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact     3120

acacccagaa aagtctgtct ctgtcccctg gcagaaagag aagaggatca ggggccccag     3180

tgaagcagac cctgaacttt gatctgctga agctggctgg ggatgttgag agcaaccctg     3240

gacctatgta taggatgcaa ctgctcctcc tgattgctct gagcctggct cttgtgacca     3300

actctgacat ccagatgaca cagagcccct ccacactgtc tgcatctgtg ggagacagag     3360

tgaccatcac ctgtagagcc agccagtcta tctcttcctg gctggcctgg tatcagcaaa     3420

agcctggcaa ggcccctaag ctgctgatct acaaggccag cacacttgag tcaggggtgc     3480

cctccagatt ttctggctct ggatctggca cagagttcac cctgaccatc agctccctgc     3540

agccagatga ctttgccacc tactactgcc agcagtacaa tacctactgg acctttggcc     3600

agggaacaaa ggtggaaatc aagagaacag tggctgcccc atctgtgttc atcttcccac     3660

catctgatga acagctgaag tctggcactg cctctgttgt gtgcctgctg aacaactttt     3720

accctagaga agccaaggtg cagtggaaag tggataatgc cctgcagtct ggcaatagcc     3780

aagaatctgt gacagagcag gactccaagg attccaccta cagcctgagc agcaccctga     3840

cactgagcaa ggctgactat gagaagcaca aagtgtatgc ctgtgaagtg acacaccagg     3900

gactgagcag cccagtgacc aagagcttca acaggggaga gtgctgataa ctcgaggacg     3960

gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat ggggacatca     4020

tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag     4080

tgtgttggaa ttttttgtgt ctctca                                          4106


<210>  153
<211>  4092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; CAG.LANv2.T2A

<400>  153
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccgccacca     1740

tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc accaattctg     1800

aggtccagct gcttgagagt ggtggtggac tggttcagcc tggtggcagc ctgagactgt     1860

cttgtgctgc ctctggcttc accttcagcc actatatcat gatgtgggtc agacaggccc     1920

ctggcaaagg cctggaatgg gtgtcaggca tctacagcag tggtggcatc acagtgtatg     1980

ctgactctgt gaagggcaga ttcaccatca gcagagacaa cagcaagaac accctgtacc     2040

tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc tatagaagaa     2100

ttggggtgcc cagaagggat gagtttgaca tctggggcca gggcaccatg gttacagtgt     2160

cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc aagagcacca     2220

gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag cctgtgactg     2280

tgtcctggaa ctctggggct ctgacttctg gggtgcacac ctttccagct gtgctgcagt     2340

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc ctgggcacac     2400

agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac aagagagtgg     2460

aacccaagag ctgtgacaag acccacacct gtcctccatg tcctgctcca gaactgcttg     2520

gaggcccttc tgtgttcctg tttcctccaa agcctaagga caccctgatg atcagcagaa     2580

cccctgaagt gacctgtgtg gtggttgatg tgtcccatga ggacccagaa gtgaagttca     2640

attggtatgt ggatggggtt gaagtgcaca atgccaagac caagcctaga gaggaacagt     2700

acaacagcac ctacagagtg gtttctgtgc tgacagtgct gcaccaggac tggctgaatg     2760

gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatt gagaaaacca     2820

tctccaaggc caagggccag ccaagagaac cccaggttta caccctgcca cctagcagag     2880

aagagatgac caagaaccag gtgtccctga cctgcctggt taagggcttc tacccctctg     2940

acattgctgt ggaatgggag agcaatggcc agcctgaaaa caactacaag acaacccctc     3000

ctgtgctgga ctctgatggc tcattcttcc tgtacagcaa gctgactgtg gacaagtcca     3060

gatggcagca gggaaatgtg ttcagctgct ctgtgatgca tgaggccctg cacaaccact     3120

acacccagaa aagtctgtct ctgtcccctg gcagaaagag aagaggctct ggagaaggca     3180

gaggctccct gctgacatgt ggggatgttg aagagaatcc tgggcctatg tataggatgc     3240

aactgctcct cctgattgct ctgagcctgg ctcttgtgac caactctgac atccagatga     3300

cacagagccc ctccacactg tctgcatctg tgggagacag agtgaccatc acctgtagag     3360

ccagccagtc tatctctagc tggctggcct ggtatcagca aaagcctggc aaggccccta     3420

agctgctgat ctacaaggcc agcacacttg agtcaggggt gccctccaga ttttctggct     3480

ctggatctgg cacagagttc accctgacca tcagctccct gcagccagat gactttgcca     3540

cctactactg ccagcagtac aatacctact ggacctttgg ccagggaaca aaggtggaaa     3600

tcaagagaac agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga     3660

agtctggcac tgcctctgtt gtgtgcctgc tgaacaactt ttaccccaga gaagccaagg     3720

tgcagtggaa agtggataat gccctgcagt ctggcaatag ccaagaatct gtgacagagc     3780

aggactccaa ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact     3840

atgagaagca caaagtgtat gcctgtgaag tgacacacca gggactgagc agcccagtga     3900

ccaagagctt caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag     3960

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4020

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4080

gtctctcact cg                                                         4092


<210>  154
<211>  3397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; TBG.LANv2.T2A

<400>  154
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagagacag ctttattgcg gtagtttatc      720

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca      780

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag      840

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      900

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt      960

acagctctta aggctagagt acttaatacg actcactata ggctagcctc gagaattcac     1020

gcgtgccgcc accatgtaca gaatgcagct gctgctgctc attgccctgt ctctggccct     1080

ggtcaccaat tctgaggtcc agctgcttga gagtggtggt ggactggttc agcctggtgg     1140

cagcctgaga ctgtcttgtg ctgcctctgg cttcaccttc agccactata tcatgatgtg     1200

ggtcagacag gcccctggca aaggcctgga atgggtgtca ggcatctaca gcagtggtgg     1260

catcacagtg tatgctgact ctgtgaaggg cagattcacc atcagcagag acaacagcaa     1320

gaacaccctg tacctgcaga tgaactccct gagagctgag gacacagcag tgtactactg     1380

tgcctataga agaattgggg tgcccagaag ggatgagttt gacatctggg gccagggcac     1440

catggttaca gtgtcctctg ccagcacaaa gggcccctct gtttttccac tggctcccag     1500

cagcaagagc accagtggtg gaacagctgc cctgggctgt ctggtcaagg attacttccc     1560

tgagcctgtg actgtgtcct ggaactctgg ggctctgact tctggggtgc acacctttcc     1620

agctgtgctg cagtcctctg gcctgtactc tctgtcctct gtggtcacag tgcctagctc     1680

tagcctgggc acacagacct acatctgcaa tgtgaaccac aagcctagca acaccaaggt     1740

ggacaagaga gtggaaccca agagctgtga caagacccac acctgtcctc catgtcctgc     1800

tccagaactg cttggaggcc cttctgtgtt cctgtttcct ccaaagccta aggacaccct     1860

gatgatcagc agaacccctg aagtgacctg tgtggtggtt gatgtgtccc atgaggaccc     1920

agaagtgaag ttcaattggt atgtggatgg ggttgaagtg cacaatgcca agaccaagcc     1980

tagagaggaa cagtacaaca gcacctacag agtggtttct gtgctgacag tgctgcacca     2040

ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgctcc     2100

tattgagaaa accatctcca aggccaaggg ccagccaaga gaaccccagg tttacaccct     2160

gccacctagc agagaagaga tgaccaagaa ccaggtgtcc ctgacctgcc tggttaaggg     2220

cttctacccc tctgacattg ctgtggaatg ggagagcaat ggccagcctg aaaacaacta     2280

caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtaca gcaagctgac     2340

tgtggacaag tccagatggc agcagggaaa tgtgttcagc tgctctgtga tgcatgaggc     2400

cctgcacaac cactacaccc agaaaagtct gtctctgtcc cctggcagaa agagaagagg     2460

ctctggagaa ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc     2520

tatgtatagg atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc     2580

tgacatccag atgacacaga gcccctccac actgtctgca tctgtgggag acagagtgac     2640

catcacctgt agagccagcc agtctatctc tagctggctg gcctggtatc agcaaaagcc     2700

tggcaaggcc cctaagctgc tgatctacaa ggccagcaca cttgagtcag gggtgccctc     2760

cagattttct ggctctggat ctggcacaga gttcaccctg accatcagct ccctgcagcc     2820

agatgacttt gccacctact actgccagca gtacaatacc tactggacct ttggccaggg     2880

aacaaaggtg gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc     2940

tgatgaacag ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttttaccc     3000

cagagaagcc aaggtgcagt ggaaagtgga taatgccctg cagtctggca atagccaaga     3060

atctgtgaca gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact     3120

gagcaaggct gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact     3180

gagcagccca gtgaccaaga gcttcaacag gggagagtgc tgataagtcg acccgggcgg     3240

cctcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     3300

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     3360

cattgcaata gtgtgttgga attttttgtg tctctca                              3397


<210>  155
<211>  3226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; ApoE.hAAT.LANv2.T2A

<400>  155
ggctcagagg cacacaggag tttctgggct caccctgccc ccttccaacc cctcagttcc       60

catcctccag cagctgtttg tgtgctgcct ctgaagtcca cactgaacaa acttcagcct      120

actcatgtcc ctaaaatggg caaacattgc aagcagcaaa cagcaaacac acagccctcc      180

ctgcctgctg accttggagc tggggcagag gtcagagacc tctctgggcc catgccacct      240

ccaacatcca ctcgacccct tggaatttcg gtggagagga gcagaggttg tcctggcgtg      300

gtttaggtag tgtgagaggg gtacccgggg atcttgctac cagtggaaca gccactaagg      360

attctgcagt gagagcagag ggccagctaa gtggtactct cccagagact gtctgactca      420

cgccaccccc tccaccttgg acacaggacg ctgtggtttc tgagccaggt acaatgactc      480

ctttcggtaa gtgcagtgga agctgtacac tgcccaggca aagcgtccgg gcagcgtagg      540

cgggcgactc agatcccagc cagtggactt agcccctgtt tgctcctccg ataactgggg      600

tgaccttggt taatattcac cagcagcctc ccccgttgcc cctctggatc cactgcttaa      660

atacggacga ggacagggcc ctgtctcctc agcttcaggc accaccactg acctgggaca      720

gtcaggtaag tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcttgt      780

cgagacagag aagactcttg cgtttctgat aggcacctat tggtcttact gacatccact      840

ttgcctttct ctccacaggt tcgaattcgc cgccaccatg tacagaatgc agctgctgct      900

gctcattgcc ctgtctctgg ccctggtcac caattctgag gtccagctgc ttgagagtgg      960

tggtggactg gttcagcctg gtggcagcct gagactgtct tgtgctgcct ctggcttcac     1020

cttcagccac tatatcatga tgtgggtcag acaggcccct ggcaaaggcc tggaatgggt     1080

gtcaggcatc tacagcagtg gtggcatcac agtgtatgct gactctgtga agggcagatt     1140

caccatcagc agagacaaca gcaagaacac cctgtacctg cagatgaact ccctgagagc     1200

tgaggacaca gcagtgtact actgtgccta tagaagaatt ggggtgccca gaagggatga     1260

gtttgacatc tggggccagg gcaccatggt tacagtgtcc tctgccagca caaagggccc     1320

ctctgttttt ccactggctc ccagcagcaa gagcaccagt ggtggaacag ctgccctggg     1380

ctgtctggtc aaggattact tccctgagcc tgtgactgtg tcctggaact ctggggctct     1440

gacttctggg gtgcacacct ttccagctgt gctgcagtcc tctggcctgt actctctgtc     1500

ctctgtggtc acagtgccta gctctagcct gggcacacag acctacatct gcaatgtgaa     1560

ccacaagcct agcaacacca aggtggacaa gagagtggaa cccaagagct gtgacaagac     1620

ccacacctgt cctccatgtc ctgctccaga actgcttgga ggcccttctg tgttcctgtt     1680

tcctccaaag cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt     1740

ggttgatgtg tcccatgagg acccagaagt gaagttcaat tggtatgtgg atggggttga     1800

agtgcacaat gccaagacca agcctagaga ggaacagtac aacagcacct acagagtggt     1860

ttctgtgctg acagtgctgc accaggactg gctgaatggc aaagagtaca agtgcaaggt     1920

gtccaacaag gccctgcctg ctcctattga gaaaaccatc tccaaggcca agggccagcc     1980

aagagaaccc caggtttaca ccctgccacc tagcagagaa gagatgacca agaaccaggt     2040

gtccctgacc tgcctggtta agggcttcta cccctctgac attgctgtgg aatgggagag     2100

caatggccag cctgaaaaca actacaagac aacccctcct gtgctggact ctgatggctc     2160

attcttcctg tacagcaagc tgactgtgga caagtccaga tggcagcagg gaaatgtgtt     2220

cagctgctct gtgatgcatg aggccctgca caaccactac acccagaaaa gtctgtctct     2280

gtcccctggc agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg     2340

ggatgttgaa gagaatcctg ggcctatgta taggatgcaa ctgctcctcc tgattgctct     2400

gagcctggct cttgtgacca actctgacat ccagatgaca cagagcccct ccacactgtc     2460

tgcatctgtg ggagacagag tgaccatcac ctgtagagcc agccagtcta tctctagctg     2520

gctggcctgg tatcagcaaa agcctggcaa ggcccctaag ctgctgatct acaaggccag     2580

cacacttgag tcaggggtgc cctccagatt ttctggctct ggatctggca cagagttcac     2640

cctgaccatc agctccctgc agccagatga ctttgccacc tactactgcc agcagtacaa     2700

tacctactgg acctttggcc agggaacaaa ggtggaaatc aagagaacag tggctgcccc     2760

atctgtgttc atcttcccac catctgatga acagctgaag tctggcactg cctctgttgt     2820

gtgcctgctg aacaactttt accccagaga agccaaggtg cagtggaaag tggataatgc     2880

cctgcagtct ggcaatagcc aagaatctgt gacagagcag gactccaagg attccaccta     2940

cagcctgagc agcaccctga cactgagcaa ggctgactat gagaagcaca aagtgtatgc     3000

ctgtgaagtg acacaccagg gactgagcag cccagtgacc aagagcttca acaggggaga     3060

gtgctgataa ctcgaggacg gggtgaacta cgcctgagga tccgatcttt ttccctctgc     3120

caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa     3180

atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca                    3226


<210>  156
<211>  3472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; LSPX1.LANv2.T2A

<400>  156
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     1020

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1080

atccactttg cctttctctc cacaggttga attcgccgcc accatgtaca gaatgcagct     1140

gctgctgctc attgccctgt ctctggccct ggtcaccaat tctgaggtcc agctgcttga     1200

gagtggtggt ggactggttc agcctggtgg cagcctgaga ctgtcttgtg ctgcctctgg     1260

cttcaccttc agccactata tcatgatgtg ggtcagacag gcccctggca aaggcctgga     1320

atgggtgtca ggcatctaca gcagtggtgg catcacagtg tatgctgact ctgtgaaggg     1380

cagattcacc atcagcagag acaacagcaa gaacaccctg tacctgcaga tgaactccct     1440

gagagctgag gacacagcag tgtactactg tgcctataga agaattgggg tgcccagaag     1500

ggatgagttt gacatctggg gccagggcac catggttaca gtgtcctctg ccagcacaaa     1560

gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg gaacagctgc     1620

cctgggctgt ctggtcaagg attacttccc tgagcctgtg actgtgtcct ggaactctgg     1680

ggctctgact tctggggtgc acacctttcc agctgtgctg cagtcctctg gcctgtactc     1740

tctgtcctct gtggtcacag tgcctagctc tagcctgggc acacagacct acatctgcaa     1800

tgtgaaccac aagcctagca acaccaaggt ggacaagaga gtggaaccca agagctgtga     1860

caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc cttctgtgtt     1920

cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg     1980

tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg     2040

ggttgaagtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag     2100

agtggtttct gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg     2160

caaggtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca aggccaaggg     2220

ccagccaaga gaaccccagg tttacaccct gccacctagc agagaagaga tgaccaagaa     2280

ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg     2340

ggagagcaat ggccagcctg aaaacaacta caagacaacc cctcctgtgc tggactctga     2400

tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc agcagggaaa     2460

tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaaaagtct     2520

gtctctgtcc cctggcagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac     2580

atgtggggat gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat     2640

tgctctgagc ctggctcttg tgaccaactc tgacatccag atgacacaga gcccctccac     2700

actgtctgca tctgtgggag acagagtgac catcacctgt agagccagcc agtctatctc     2760

tagctggctg gcctggtatc agcaaaagcc tggcaaggcc cctaagctgc tgatctacaa     2820

ggccagcaca cttgagtcag gggtgccctc cagattttct ggctctggat ctggcacaga     2880

gttcaccctg accatcagct ccctgcagcc agatgacttt gccacctact actgccagca     2940

gtacaatacc tactggacct ttggccaggg aacaaaggtg gaaatcaaga gaacagtggc     3000

tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagtctg gcactgcctc     3060

tgttgtgtgc ctgctgaaca acttttaccc cagagaagcc aaggtgcagt ggaaagtgga     3120

taatgccctg cagtctggca atagccaaga atctgtgaca gagcaggact ccaaggattc     3180

cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga agcacaaagt     3240

gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga gcttcaacag     3300

gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg atctttttcc     3360

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     3420

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct ca             3472


<210>  157
<211>  3553
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; LSPX2.LANv2.T2A

<400>  157
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt caggtaagta tcaaggttac aagacaggtt     1080

taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag     1140

gcacctattg gtcttactga catccacttt gcctttctct ccacaggttg aattcgccgc     1200

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1260

ttctgaggtc cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag     1320

actgtcttgt gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca     1380

ggcccctggc aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt     1440

gtatgctgac tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct     1500

gtacctgcag atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag     1560

aagaattggg gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac     1620

agtgtcctct gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag     1680

caccagtggt ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt     1740

gactgtgtcc tggaactctg gggctctgac ttctggggtg cacacctttc cagctgtgct     1800

gcagtcctct ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg     1860

cacacagacc tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagag     1920

agtggaaccc aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact     1980

gcttggaggc ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag     2040

cagaacccct gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa     2100

gttcaattgg tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga     2160

acagtacaac agcacctaca gagtggtttc tgtgctgaca gtgctgcacc aggactggct     2220

gaatggcaaa gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa     2280

aaccatctcc aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag     2340

cagagaagag atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc     2400

ctctgacatt gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac     2460

ccctcctgtg ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa     2520

gtccagatgg cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa     2580

ccactacacc cagaaaagtc tgtctctgtc ccctggcaga aagagaagag gctctggaga     2640

aggcagaggc tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag     2700

gatgcaactg ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgacatcca     2760

gatgacacag agcccctcca cactgtctgc atctgtggga gacagagtga ccatcacctg     2820

tagagccagc cagtctatct ctagctggct ggcctggtat cagcaaaagc ctggcaaggc     2880

ccctaagctg ctgatctaca aggccagcac acttgagtca ggggtgccct ccagattttc     2940

tggctctgga tctggcacag agttcaccct gaccatcagc tccctgcagc cagatgactt     3000

tgccacctac tactgccagc agtacaatac ctactggacc tttggccagg gaacaaaggt     3060

ggaaatcaag agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgaaca     3120

gctgaagtct ggcactgcct ctgttgtgtg cctgctgaac aacttttacc ccagagaagc     3180

caaggtgcag tggaaagtgg ataatgccct gcagtctggc aatagccaag aatctgtgac     3240

agagcaggac tccaaggatt ccacctacag cctgagcagc accctgacac tgagcaaggc     3300

tgactatgag aagcacaaag tgtatgcctg tgaagtgaca caccagggac tgagcagccc     3360

agtgaccaag agcttcaaca ggggagagtg ctgataactc gaggacgggg tgaactacgc     3420

ctgaggatcc gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     3480

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     3540

tttgtgtctc tca                                                        3553


<210>  158
<211>  3592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; LTP1.LANv2.T2A

<400>  158
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg     1140

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1200

atccactttg cctttctctc cacaggttga attcgccgcc accatgtaca gaatgcagct     1260

gctgctgctc attgccctgt ctctggccct ggtcaccaat tctgaggtcc agctgcttga     1320

gagtggtggt ggactggttc agcctggtgg cagcctgaga ctgtcttgtg ctgcctctgg     1380

cttcaccttc agccactata tcatgatgtg ggtcagacag gcccctggca aaggcctgga     1440

atgggtgtca ggcatctaca gcagtggtgg catcacagtg tatgctgact ctgtgaaggg     1500

cagattcacc atcagcagag acaacagcaa gaacaccctg tacctgcaga tgaactccct     1560

gagagctgag gacacagcag tgtactactg tgcctataga agaattgggg tgcccagaag     1620

ggatgagttt gacatctggg gccagggcac catggttaca gtgtcctctg ccagcacaaa     1680

gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg gaacagctgc     1740

cctgggctgt ctggtcaagg attacttccc tgagcctgtg actgtgtcct ggaactctgg     1800

ggctctgact tctggggtgc acacctttcc agctgtgctg cagtcctctg gcctgtactc     1860

tctgtcctct gtggtcacag tgcctagctc tagcctgggc acacagacct acatctgcaa     1920

tgtgaaccac aagcctagca acaccaaggt ggacaagaga gtggaaccca agagctgtga     1980

caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc cttctgtgtt     2040

cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg     2100

tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt atgtggatgg     2160

ggttgaagtg cacaatgcca agaccaagcc tagagaggaa cagtacaaca gcacctacag     2220

agtggtttct gtgctgacag tgctgcacca ggactggctg aatggcaaag agtacaagtg     2280

caaggtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca aggccaaggg     2340

ccagccaaga gaaccccagg tttacaccct gccacctagc agagaagaga tgaccaagaa     2400

ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg ctgtggaatg     2460

ggagagcaat ggccagcctg aaaacaacta caagacaacc cctcctgtgc tggactctga     2520

tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc agcagggaaa     2580

tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc agaaaagtct     2640

gtctctgtcc cctggcagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac     2700

atgtggggat gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat     2760

tgctctgagc ctggctcttg tgaccaactc tgacatccag atgacacaga gcccctccac     2820

actgtctgca tctgtgggag acagagtgac catcacctgt agagccagcc agtctatctc     2880

tagctggctg gcctggtatc agcaaaagcc tggcaaggcc cctaagctgc tgatctacaa     2940

ggccagcaca cttgagtcag gggtgccctc cagattttct ggctctggat ctggcacaga     3000

gttcaccctg accatcagct ccctgcagcc agatgacttt gccacctact actgccagca     3060

gtacaatacc tactggacct ttggccaggg aacaaaggtg gaaatcaaga gaacagtggc     3120

tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagtctg gcactgcctc     3180

tgttgtgtgc ctgctgaaca acttttaccc cagagaagcc aaggtgcagt ggaaagtgga     3240

taatgccctg cagtctggca atagccaaga atctgtgaca gagcaggact ccaaggattc     3300

cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga agcacaaagt     3360

gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga gcttcaacag     3420

gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg atctttttcc     3480

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     3540

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct ca             3592


<210>  159
<211>  4083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; LMTP6.LANv2.T2A

<400>  159
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtaagtat caaggttaca agacaggttt aaggagacca     1620

atagaaactg ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg     1680

tcttactgac atccactttg cctttctctc cacaggttcg aattcgccgc caccatgtac     1740

agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa ttctgaggtc     1800

cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag actgtcttgt     1860

gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca ggcccctggc     1920

aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt gtatgctgac     1980

tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct gtacctgcag     2040

atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag aagaattggg     2100

gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac agtgtcctct     2160

gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt     2220

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gactgtgtcc     2280

tggaactctg gggctctgac ttctggggtg cacacctttc cagctgtgct gcagtcctct     2340

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacacagacc     2400

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagag agtggaaccc     2460

aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact gcttggaggc     2520

ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct     2580

gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa gttcaattgg     2640

tatgtggatg gggttgaagt gcacaatgcc aagaccaagc ctagagagga acagtacaac     2700

agcacctaca gagtggtttc tgtgctgaca gtgctgcacc aggactggct gaatggcaaa     2760

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctattgagaa aaccatctcc     2820

aaggccaagg gccagccaag agaaccccag gtttacaccc tgccacctag cagagaagag     2880

atgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc ctctgacatt     2940

gctgtggaat gggagagcaa tggccagcct gaaaacaact acaagacaac ccctcctgtg     3000

ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa gtccagatgg     3060

cagcagggaa atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa ccactacacc     3120

cagaaaagtc tgtctctgtc ccctggcaga aagagaagag gctctggaga aggcagaggc     3180

tccctgctga catgtgggga tgttgaagag aatcctgggc ctatgtatag gatgcaactg     3240

ctcctcctga ttgctctgag cctggctctt gtgaccaact ctgacatcca gatgacacag     3300

agcccctcca cactgtctgc atctgtggga gacagagtga ccatcacctg tagagccagc     3360

cagtctatct ctagctggct ggcctggtat cagcaaaagc ctggcaaggc ccctaagctg     3420

ctgatctaca aggccagcac acttgagtca ggggtgccct ccagattttc tggctctgga     3480

tctggcacag agttcaccct gaccatcagc tccctgcagc cagatgactt tgccacctac     3540

tactgccagc agtacaatac ctactggacc tttggccagg gaacaaaggt ggaaatcaag     3600

agaacagtgg ctgccccatc tgtgttcatc ttcccaccat ctgatgaaca gctgaagtct     3660

ggcactgcct ctgttgtgtg cctgctgaac aacttttacc ccagagaagc caaggtgcag     3720

tggaaagtgg ataatgccct gcagtctggc aatagccaag aatctgtgac agagcaggac     3780

tccaaggatt ccacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag     3840

aagcacaaag tgtatgcctg tgaagtgaca caccagggac tgagcagccc agtgaccaag     3900

agcttcaaca ggggagagtg ctgataactc gaggacgggg tgaactacgc ctgaggatcc     3960

gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact     4020

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc     4080

tca                                                                   4083


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Y-sulfation site

<400>  160

Glu Asp Thr Ala Val Tyr Tyr 
1               5           


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Y-sulfation site

<400>  161

Asp Asp Phe Ala Thr Tyr Tyr 
1               5           


<210>  162
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  162

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  163
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  163
ggatataccc tcctatgctc ctcttttcat tctcaaagcc accctgttcc tggaatgtga       60

gatctcctaa ttgttgactg gagaatcaaa tgctaccttt gcaacagctt atcggaagca      120

aacaagctga ggggaattga gcaagaattt ctgggatacc aacagcatag gaggaacaaa      180

ggacgtagag ggagggttga ctgtctacac aggacaaagc caatgattaa ccaaacctct      240

tgcagattta aataggatgg gaactaggag tggcagcaat cctttctttc agctggagtg      300

ctcctcagga gccagcccca cccttagaaa agatgttttc catgaggat                  349


<210>  164
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  164
ggtagacagg aaaaaaggca aaggctacca tctgctatta ctgatgatat tactgaggaa       60

ttgatacatt tctatctata gagatttatt aatgtacaac tggttctaca actttatttg      120

ttcagtctac ataaccaaaa tgaggcttca agtccggaag ttccctgtta cccaaggcaa      180

acgtattagg gtctgttctg ccatctggtg ttctttgaag gaaacatcca cagaggcatt      240

atgagataaa tagccagtgt tgcctatgtt ggtggtgggt gttacaacct cgatgaaaag      300

caattccaga atctctgcca aattccaata ggagataatt tgagaatat                  349


<210>  165
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  165
caaccccgga aacaacaagt ttctgtcaaa agcaataatg aactgttttg tgccattaac       60

aaaaacgtta tgaagacaga aaccatctcc caaagatttc ataacagagc cacataagtg      120

gaaagtaaat gattaaagaa tgtgggtctc agagttccat tcaaatcatg atactttatc      180

ttctatttac aaagataaaa gtacaccaga aaatggttaa tgtttaagcg ctttcatatt      240

tggctctgtc tttttagcag acgaaaacca ctttggtagt gccagtgtga ctcatccaca      300

atgatttctc cagtgctcat cttgttctcg agttttctct gccatgttg                  349


<210>  166
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  166
aagccctgtg acatgtttat accccttata aatgcatatc tagttcctga catattttat       60

cataaagaga aggcatttga atcttttctc tgaaatgtgg ttggtagata ttgactagaa      120

ttccaactca gaaggagaca acattgaaag taggttttta aacaaataat ctaaactgtt      180

gctaaatgtt taatatcatg gtcaaagtct ctgcttggga agtaaataag aaagtttttg      240

aacatgtgat gcaatgtggt ttcaggaata caaaaacctt ggactctgaa tccaggtctc      300

tatagtttaa tttacaaatt agcgtaaga                                        329


<210>  167
<211>  237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  167
agtgcatagt tttccaattg aagtataatc aagtaaacac acagatctta aatatttggc       60

ttgatggctt ttgaaaattg catgtagcca agtaacaacc acctaaaata gaatataaac      120

tatttcgaca cccctacccc aagtttccta atgcaaggga gcccagccac caggaaacat      180

cattaaaaac ccttctcctt gtcctctctc aatatcaggc actcagtttg tagctgt         237


<210>  168
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  168
agcccacaaa agccgtcaaa ctaagtttga tttagtggtt tctccatttt cctgtcactg       60

ttattttgca taatttttca aagctcagta gctggcaaat aggagctgag tgtcaatgat      120

ggcggtgggg tgggggccaa gcttgtattc ctctttaggg ggcgatgcaa ataaaatttg      180

aggcctcgta tgatccagtt taaaaatcac atctcaatag aaggactttc aaggaaacca      240

caaaaagcgt ccttccttcc t                                                261


<210>  169
<211>  301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  169
agacccttcc attcaagtgt caccaaatgc cccttcgggc ccacactgtg cacccagttc       60

tcatgtccac ctgggttccc taagtctttc tttgcctttc atggcttttg cccttttgaa      120

gatgacaggg cagtcatttt gcataacgtc cttcaatttg tgtgtgtaca gtgccttctc      180

atgacacaat ccaggttact aagcttttgg caggaatatc acagaagtga cgctgtgtcc      240

ttctcattgc atcctcttgg tggaggacat acatgccaat ttatcccatt agtggtgaca      300

t                                                                      301


<210>  170
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  170
ggggctcatc catgtaagtc tcatctgcaa tcactgggct gatcccgtgg ccctgtctcc       60

agggcgccat cagagagggc ttcaatcctc aggttacctg tggcccaccc tgccctcaga      120

ggtgccatct ctacattggc cacgagatgg cagcacatac tcatagactg cattaatttc      180

ccagcaactc ctggtgggtt ttccctctta tcaggatgtt tgccttgctc agagagcaaa      240

tctgagagca gtgacaccta acttaacttt cagcaaaata ttttgagaag ggtgcccctt      300

tacacatctg tgcagtccag gtgatgcat                                        329


<210>  171
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  171
tctgggtgcc cactccaggg cctggcttgg ctgccaactc cagtcaggga ctttcagcca       60

cccctccccc caggttattt caggagcacc tgcctgggcc tgggatggct tctctggtga      120

aagaaacacc aggattgcat cagggaggag gaggctggga tgtccagggt ctgagcatct      180

gagcagggac agatgaggtt gaggttggcc cacggccagg tgagaggctt ccaaggcagg      240

atacttgtgt ctc                                                         253


<210>  172
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  172
gagatcctca caccttggcc ttccaaagca ctgggattac aggcgtgagc cactgtgctc       60

cctccgccta gactgtgatc ggcctaaatc tgatggtttc tttaagacca gtttttacag      120

agaaggcagc gggcttgcat tcttctgtgc cactggcaag gactgccacc agagggcgct      180

ctaccatccc ttctggtgct ccctgggccc tgatcttgct ttccactcat gccgcaaaaa      240

gccagctact cttcaagatt aaactctcca gggctttctt ttatagatag gatgagaagc      300

aaagaacttc tttgatttta cagcctggat cttttcagtt ttggttgtat                 350


<210>  173
<211>  283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  173
ccttctcttc aagttggttg ccccggtgac ctttcgccac caccgctatg atgatcttgt       60

gcggacgctg tacaaggtgc aaaacgaatg ccccggcatc acgcgggtct acagcattgg      120

gcgcagcgtg gaggggagac acctctacgt gctggagttc agcgaccacc ctggaatcca      180

cgagccctgt aagttctgaa cagctcttga gggtgtgtgg ggcagggcct ttcccttgca      240

aatccagtaa ttggagtggt ttctggggtg gtccgtggac gcc                        283


<210>  174
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  174
ctaggattac aggtatgagc caccatgcct ggcctctttt ctctcttaag gtcaccctgg       60

catgtagtct ggcctgactc tgcctgtgta aacacaaagg agcaagggtc aagtgcacca      120

tgtaatctgc ccacatactc tcaggatgac cctggtcttt gtaaactttg ctttgagaac      180

cagtgatatg agcatcactt acagagggac tgtgtgggag gggggaacag tgctctttgg      240

gagagtcaat caggccagtg cagtgggttc aggcttcaag aaaga                      285


<210>  175
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  175
caccttatgc caaagtctgt tctatcctgg accacattct gtggtagtgt ttgtttaact       60

tttcaatttc tctttcaacc ctgactagtc tgtaagttac ttaagggtag tgactgtatc      120

ttcctcatgt ttttaccccc atagagccca gcatataata ctagctcaac acatgtttgc      180

ccgatcaagt caccaataaa caaaagaatg agccagcttc ctcccggttc cttggcaagt      240

gtgaataact aagtcatttg tagttgacac tcagctcaga ggctgagggt tctaaatgta      300

tgtcccccaa agggattcat cttatgcact tcattaccag tcaagctatc                 350


<210>  176
<211>  193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  176
tttcttcacg tgaattcaga ttctactgaa ttcagctctg caccaagtcc catcctctgc       60

tgccctctgt ttcagcaaac actgaggcct gttgtttctc ctcctctacc ggctctgatg      120

cggtcaaggt ccagagagct gagtagttgg caagcggacc accagcaaca gacaacatct      180

tcattcggct ctc                                                         193


<210>  177
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  177
gccagaaggg ccaaggggag gatggggcgg acccgggcag gggtcctggc tggaggggag       60

cagaagagga gctctgggat taaccccggt gggtgccact tagggccaga gcctctccca      120

ggtgggacct gcgtctcatg gtggctgcgc ggccatcgct ggggccaagg cgccgcctgg      180

tggtgaggcc gggccctgca gccacacagg cgtgccccag gcaggggaca ggtgggcagg      240

gtctgtgggg tgcggtgcca gccgccctgc tcacatgggt cctgggacac atgggagggg      300

tctgctgcct gacagtgtgg gtgtcaggct tccaggaagc cacgtg                     346


<210>  178
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  178
actaggacca gtgcaggccg aggccagaga gacagctggg cttccaggta gggtcaaagt       60

gaggtgggca gcaggtgtgg gggccagggg actcggggac ttcctctccg gctgggcccg      120

cctgacgtgg gaggcagcca gggttaatca tttccacgaa gccttgaccc cacctgcctt      180

ggccgctctg ctcccgcctc ccactgcccc tcaggccagc tcaggagcca tggggcgctg      240

ggcctgggtc cccagcccct ggcccccacc ggggctgggc cccttcctcc tcctcctcct      300

gctgctgctg ctgc                                                        314


<210>  179
<211>  202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  179
aaactgacgt cagggtttaa gcttggtggg tagcagtgcc tgggcctggg cagtgaccct       60

gagcaggtgt taactagggg ccgagggcgg ggaaggtgtc agggcctggc tgaggcctca      120

ggaatgtcgt gtgtcctcct ggaacctgct ccgagatctg ggggccccag tatggaaaca      180

ggctcagggc tgtgacctcc tg                                               202


<210>  180
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  180
cctccccaca gcactcaccg aggacgggag gccctgcagg ttccccttcc gctacggggg       60

ccgcatgctg catgcctgca cttcggaggg cagtgcacac aggaagtggt gggtccgggc      120

agccggggca cccgagctgg ggtcacctgc cccacgctgc ctgcttttct gggagccggg      180

cacacagtag gcgctca                                                     197


<210>  181
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  181
gccaccctga aaggaaggac acaaggttgg ctggtttcac cacctcctga ttgtagaacc       60

ctaggacctt tagcaaatat aggtggtaac aaggaaatgc ttaccttggg ccttggccaa      120

gacccagtgc tatgctgtct tcaggtctga cccaggacag tcctagtggt agtggcctca      180

gggagttttt gt                                                          192


<210>  182
<211>  184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  182
tgggagccca ctgccctaaa gggtgagtcc caggtctgga agcattcacc acaagctgac       60

caaacagccc ttggaccata agttaataat caccctggaa gtattccaca tgggcctgtg      120

gcggtattgg acacacagac agattcctct tctggtggaa aggggagaga agagtggaaa      180

ggat                                                                   184


<210>  183
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  183
ttccagccgg ctccgctccg ggtcccccag tgctcgctgg ctccccgctt gagccagccc       60

gcccgcccag cgctaggggc caaggagcga accgcacctg cgatccgatt gtccggggca      120

cgccgtagag gatgggagga cccatgaggc gctagcctgc gaaggtggcg gtgctgctgc      180

tccggctgct cttggagttg catgtacacg acgtggcaga ctttccaatg ggaggattgt      240

ggattctgat gacataggaa acttcatctt ccagacattg ccacagaaag cacacagact      300

ttggaaacca gcagacctga agtcaaatgt cgactttcag cttgctcctg                 350


<210>  184
<211>  338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  184
ctcgcgagcc cgcgtgagtg cccaggggaa ggggtgtagg cgaagggagg agacagctgg       60

gccatgccat gatgacctgc ctctgctgcc tcaacctctg tggccgctgc tgggacagag      120

gaaaggagcg gtgctagctc tgtctgcaga tcccggccat cctgggctct ttagcgccct      180

ctgcctgcag cccccgcctt gacaactccg tagctgttgc ccccttgctc actgaggcgc      240

gggacctggg atcaatcggg aggacgcccg ctgcagtccc cagaatcaaa ggatgatgtg      300

gcgcatctat gtttctttgg agagtgttgt aggtctgg                              338


<210>  185
<211>  344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  185
acacagtgac tctgggtagt tgtgtaagag aggggccctt ggcagacaaa caggttcttc       60

tctgttggtg ggccagccag caggtcagtg ggaaggttaa aggtcatggg gtttgggaga      120

aactgggtga ggagttcagc cccatccccc gtaaagctcc tgggaagcac ttctctactg      180

gggcagcccc tgataccagg gcactcatta accctctggg tgccagggaa agggcaggag      240

gtgagtgctg ggaggcagct gaggtcaact tcttttgaac ttccacgtgg tatttactca      300

gagcaattgg tgccagaggc tcagggccct ggagtataaa gcag                       344


<210>  186
<211>  338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  186
ggttatagga ggagctgggg agtatgggaa gcctcccact tggtctttgg ttttccagaa       60

actccaccat cacaagcagg atgttaatca gtaaccgtcc cacaggggat catactttgg      120

aatagcaaat atttgctgaa ggttctgggc tgcaaagctg aagctttggt ttctgctcta      180

aatgaaggac ttttccagga cccaaggcca cacactggta agaggcagtg ggttacagga      240

gaccttcaat gagtctaatc agggagggac cgggaaggat ggtatcatcc ctgggcgggc      300

tccaacgtga gggctgtgtg gctgagcagt gcaaagac                              338


<210>  187
<211>  184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  187
ccagggctga gaagtggcag gtgagctggt gattccttac tgcccaggtt ctgtctagga       60

aggtgcgtcc tcaccatgct ggatggtgtc ctagtccagg agcaccccct gagctcctgg      120

cctagactcc aaagggttgg gtagatgagc aaagacttta caaagacctt aggcgatata      180

tgtc                                                                   184


<210>  188
<211>  292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  188
tgatgccacg taatcgtttt agctcaggct cctctaacaa aacaccacag gctgggtggc       60

tccaacagcc attgattttt cacagttttg gaggctgaaa gtccgagtca gggtgccagc      120

gtggccggat tctggtaggg ctgtcttctt ggcttgcaga tggccacctt cgcaccgtgt      180

cctcccatgg agaggaggtg cggaggggga ctctgctctc ttcttatgac agcactagtg      240

ctatcacagg ggccttgccc tcacgacctc atctaaacct aatcacctcc ca              292


<210>  189
<211>  256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  189
tctgctctcc caaggccaca gggccctacg attgtctctc cctttccttt cgttaggcca       60

gcatatgatt aacgctacgt gattttctat gaatgtgttt tcacgtttca aaaacagatt      120

gatacacata ttgaacagtg ccagacgctg tcatttgagg cccttccctg gtatcctatg      180

tgcttgtagt ccttattatt ttcagagcac tctacatagc tcccctctga cacttagaag      240

catagggtct ttccaa                                                      256


<210>  190
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  190
ggtgtgaatg agacaaagtg gcagtcagag gtgccaggca aaggcttttc tctaagctgg       60

agccaactat gagggaacga ctgtgaattc cgttcaggtc caggacaatg agaggagcca      120

gggattgtta ggaaacattt ccctgctttc gtgtgcgatt cccaataggg cctgcgagtg      180

gagctgcatt ttgctagctg ggctagagga cggggaaaat tttggggaaa tttattttgc      240

ctgcctgagc tgtggaaaag ccaacccaat tagggaacgc ctttcctagt tggaacgaga      300

agacgagaag tgagagaagt gagatagaag gctccctctc                            340


<210>  191
<211>  227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  191
gaagttttct ttccgaagtt caagctagat cagaagtatg agatgcatga gctgcttagg       60

cagatgggaa tcagaagaat cttctcaccc tttgctgacc ttagtgaact ctcagctact      120

ggaagaaatc tccaagtatc cagggtaagt caggatcttt catcagagcc caacctcagc      180

atgaaatgtc accaaaacaa atgcttttac aaaccattta actttga                    227


<210>  192
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  192
gccactttcg cagagctggc accagactta caaagccccg gcaggggaag ccactttaca       60

accagccagg ccacaccccc agggcagacg tttatgtaga gagtaatgta cctgcctgct      120

agtagcctct gcattgtggg gccttctctc agaaccacac taaacagtgg gtgggtgaga      180

agtgtcactc ctgccacctt                                                  200


<210>  193
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  193
gacagggaca tttatgtcta cagaagtttc tgctgccttt tgttcagcta tgccctgccc       60

ccagaggtgg agtttacaga agcagcaggc cttgctgagc tgcagtggtc tctgcccagt      120

tcaagctttt ccagctgctt tgtttaccta ctcaagcctc agcattggcg gacgcccctc      180

cccctgccag gctgctgcct cacaggtcga tctcagactg ccacactagc agtgagcaag      240

gctctgtggg cgtggtaact gccaagccag gcacaggata cagtctcctg gtgtgtcctg      300

gagactggac acaccactaa gaccactgga aaagtgcagt atttgtgtgt g               351


<210>  194
<211>  182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  194
atttgaaggg gtatcacaat attcatctat tttctggaaa tattttccaa catgcaatta       60

gcaggaaaat tgaatgaaat taattctctc cgttctctag tttgctaagg gtaaatggtc      120

accaaataga taatgtaaag agaaatcaaa ggagagaaaa tctgctataa taaagatgac      180

aa                                                                     182


<210>  195
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  195
gcccagggac gtgtctttcc ctaaacaaac caacctctcc tcacatcccc cactctgtac       60

tttcactgac tatgcgttgg cagattctgc caagttctac ctgtaactgg cttcattttc      120

aagtcagacg tttggctgct gctctgtccc ctgcaacaag gagccatgcc agctggacac      180

acacttcttc cagggcctct ggcagccagg acagagttga gaccacagct gttgagaccc      240

tgagccctga gtctgtattg ctcaagaagg gccttcccca gcaatgacct cctcattgct      300

tctggccttt ctcctcctgg ctccaaccac agtggccact cccagag                    347


<210>  196
<211>  344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  196
tcccgacaac ccccacatcc ctctggggtc actctggtag ctcagacctg accaataggc       60

agctggaaag ctggtaaatt tcacttcttt tgagattggc tgccgtcatc tcctccggct      120

cctctctctg caggccccac aaacccacag gctgtggtgt gagcccatcc acttcctggg      180

cctgtacaca gcgactggga ggtgggagtc tctcctttct ctggccccag gatctagccc      240

ctcccttccc ctctcctcca gatgcctcat ttgagtaaaa gaagaaaaaa taaaacacca      300

ggactgcaat acctcaccat atgtcatgtt cccatatata cctc                       344


<210>  197
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  197
ataatattgc cttatagcct caaactcctg gcctcaaggg atcctcctgc ttcagcgtcc       60

tgagtagctg gggctatagg catgtgttcc catgaccagc taacaaaagg ttttatagct      120

gaccctttat ttgttttgat cttcactctg agtccctgta ttactggaaa tgccctggat      180

ttgatttttg ccctgaggta atttcttact ttaagaacct tttgtcagag agaaagaatg      240

aaaaagaatt tttgtcatta tttttctttt ctttcctcta catgtacaac atgaagtaaa      300

aggttttgtt ttgttttgtt                                                  320


<210>  198
<211>  341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  198
tgagctctat cacctgagct cccctgccct ctggcttcct gctgaggtca gggcatttct       60

tatccctgtt ccctctctgt ctaggtgtca tggttctgtg taactgtggc tattctgtgt      120

ccctacacta cctggctacc cccttccatg gccccagctc tgcctacatt ctgatataac      180

tgcttcaaca ctagggggtc ctaaaggctt tctatcttgc tagtccctgg ggcctcaaca      240

tctcatactg gttcccttaa ctctgcctat acctctgtaa ataattcctt cactaagttc      300

tcttgatgaa gcaaaaacag acagctgaaa agtcctctat c                          341


<210>  199
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  199
atttgtagtc ttatagaaat tgacaaagac tacaaatcag ggcttttgat ttttttccct       60

ggagaccagt tattaaacat ttaccagcat accactgtct gcgtcctaaa aatacaagtt      120

ctctacctcc cacgcactta acatacaatg ctgagacagg gacaggataa acataataga      180

tattcctgtt caaaatgggg tatgggagaa taggagacac agagcagtca ctgatccata      240

aaacttctta tattcagcca ggcaaatatc taggtccact ccaaacccag aattcccttg      300

gttagttagg gcctggttct gctccctggt atttcccat                             339


<210>  200
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  200
catcctgggt ggagctgccc ataggccttt tgtggcagcc cgggtgagag ttgggggcaa       60

acaccagatt caccgacgag gcatcgactg ccaaggaggg tccaggatgt gctgtcgaca      120

agagtttttt gtggacttcc gtgagattgg ctggcacgac tggatcatcc agcctgaggg      180

ctacgccatg aacttctgc                                                   199


<210>  201
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  201
agaaacagtg actggaaaag aattatcaca ttgcacaagg atggctctga aatggactac       60

agttctgctg atacaactca gtttttactt tagctctggg agttgtggaa aggtgctggt      120

atgggccgca gaatacagcc tttggatgaa tatgaagaca atcctgaaag aacttgttca      180

gagaggtcat gaggtgactg tactggcatc                                       210


<210>  202
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  202
tcttcttttc tttattccta tcaggaagac ccactacatt atctgagaca atgaggaaag       60

ctgacatatg gcttatgcga aactcctgga attttaaatt tcctcatcca ttcttaccaa      120

atgttgattt tgttggagga ctccactgca aacctgccaa acccctacct aaggtaaaca      180

tactttcgtt ggttttattt tgttggcttc aaatttcagt agaaatgact gtatagtctt      240

cattcagagt gtttgactaa cactgaaaaa gatgggaagt aggtggggta aagcagatac      300

caattagaaa ctcatgtaca tgttaatacc atcaca                                336


<210>  203
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  203
aaaaatacga gactgattat ggtcgagtac agatctctat ttcaataatt tctcaaaaat       60

ttctagctat aatttacaaa tatttttact taatattatt aagatcttag cttggatcca      120

aatgagtagt tggtacaatg atttcagcca tactcacaaa atagtccaca gttaacttga      180

agaaccaaag ataaaaggat tagcttaatg agttgtgtaa actagactat ttgttagaaa      240

attgtttcta tggttactgt agaattaatt gattatggag ctcaaagatt tgtttaaata      300

tctagaggct actattgaag ctttaaagag aaaataa                               337


<210>  204
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  204
ctcacattca gtacttcttt agatcctcat aagaaatctg ggaattaagt attattccca       60

ttttctagat aatgaggatc agacttagac aggggcagtt aggccacata gctagaaagt      120

gagtcacatt tacttagttt taccatgtga caggtctttc ccctatatca tctcccttaa      180

tcctcacaat aatcctggag ggtgtgatga ctgttctccc tttacagatg aggaaggagg      240

ctccgtgtgt catgtgccaa agatcacaca gtcggaagca gggtagctgg ggtttgaagc      300

caggttttcc ggctccagat tcaatcctcc ttgtgcttca tctactac                   348


<210>  205
<211>  299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  205
tcaaatctct ttaaaaatat aaaagtcatt cctggctcaa aggccataca aaaataagct       60

gtgggttgga cttggaccca ggctgcaatt tgctaccatc ctccacagtt atctcatctc      120

tccattagag gaacctctgt catagatact attccctccc attaaaaaga ttaggaaaca      180

ggctctgaaa aatcaagtga aaatatttga ggtcatatag ctcagaggtg gcaatgcttg      240

gatttcagac ctttggactt cgtatccagt tctcacttct ctctatccta gcacctcca       299


<210>  206
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  206
cttccagtaa gtggttttct ccccttggct ggggacccta ccagtcctga tattacctgc       60

ctgctgacct caaccgcaac ccctgaccac aggccaaagt ctgtttgcca caggtctttc      120

tgtacacatt tccaggaact cagacaaagc tattgccagt gccctcagtt gacttctgtt      180

tccagggaag tgcgactacc gtaatgtggc tcagtcctac tgctgacttg ctctggcaca      240

gtcctactgc tgacttgctc tgtgaccttg gcaaatcact tcccctttgg gggcctcagg      300

ttcctctcct taaaatgaga gatctggaga agtgccttcc tttta                      345


<210>  207
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  207
ccacccacag tggggcaagg aggtgttact ggcatccagg aggcagaggc ctgggatgct       60

gctaaacatc cttccatgca cagaacagac cccacagcaa agaaatatct ggcctcaagt      120

gtcaatactg ccaaaattga gaaaccctgc cttaaatgct taacctcaca aagtgtgaaa      180

aattctattt taaccacaaa ggaagtgatt gttctagcag ttgccaaact atttctgtcc      240

atatgtggtg tagtccattt aagagactgc atttcagact ttgaagcaaa agatcatcat      300

tttctcatcc attttctccc caccc                                            325


<210>  208
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  208
tcgaggcaat tgtttccccc aaggaatatt tggcaatgtc aggagacagt cttggttttc       60

acaactggaa gggggctgct ggcatgtagt gggtagaggc cagagactct gctaaacagc      120

ctacaataca aggacagccc actcctgcca gtaaagaatt atccaacttg atacgcaata      180

gtgccgaagt tgaaaaaccc tgaactacgg tcatgtctgg aatgggttgc atcagttgta      240

aataactccc acccagccac atgtagctgc cacagttaca ccattaggga aattgctcag      300

caatgacaac aacactacct gtcaaggatt ttattaattc                            340


<210>  209
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  209
cacagatgcc ttccctgacc ctgctgccct gtgtcagagt cctcctcgca cactacaata       60

attatctgtt tccttgtcca tttccccaca cttgactctc agctcataga ggtcaagcac      120

tctcctgagt catctttatt tctcaactag ctctaacaca gtaaaacgtc attaggtact      180

tatcaaagtt gtctcaaatg ttct                                             204


<210>  210
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  210
atagctttga aagtgagtaa attgggtttt aaaaataatt aagggagtat tatttttata       60

tctatttcta aatgtaatgt tgagtcagtt tgacccattg attgggaatt gtaactggga      120

gaattgttaa tgtttaaact gaaaagcatg agattgttct gaaacttaag tacaggcaca      180

gagccaggaa caagcagagt gtgctggctg gtgacactca aagaggtgaa cctcagagac      240

ttgcatgtcg gaagaagtgt ctaagccagg gatggcaagt ggtcttaata gcaaatgcta      300

cctagactgc tgagttgaag attggaacac aagatgcggg ctcagc                     346


<210>  211
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  211
gtaccttatc tgtacgtacc tccaacaagc tgcagtcgac cagaggaggg gaggccagtt       60

cctctcccaa gggtgccaca cacccctccc tgttcatcac cagacaggcc cttccttctt      120

agccatatgc taaccttctc ctccctggga aatttcctct gcaggagcca aagcagatgg      180

gagctggagt tgctggagct cctggtctgt atgcagagca ggcatccagg aaaggagaag      240

agagtgtgac aatccagcac ctcagaatgg aggggcctcg tgtccagggc ggaaagtaca      300

gacgcaggct tgctgagg                                                    318


<210>  212
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  212
ttttgcatca tattcacatt agttatattc tcaaggtgtc tacattgccc aatatgcgat       60

atgctgggga tggtacacag taggtgctta ctacattttc ctctcagatg gcagaattct      120

tttgtctgag gcaataactg agattagtaa aataccacag gcttctaaac ataacagact      180

tgagcgtgaa tctcagcttc accatttttt aactgtatgg ccttaggcaa tataattaac      240

cttcat                                                                 246


<210>  213
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  213
aagtctggat gggaaatcca aggtattaca attgactcca gaaaacaaag ggttgaagca       60

cagggtggag ggggctgaag ccatgtggct caatggccat gtgaaagaaa caggccaacc      120

attagtccca gttcactcag tgggagcctg atacagacgg ccccacagtg aaagacgggt      180

taacaaaagt caagagctca ggataagatt cttctctggc gtaccaagat ttttgttctt      240

ggtgccacac ctcaccggat actgacaaag caaagcaggc aatccagaga agtgggaagg      300

ctcaaaccta tgt                                                         313


<210>  214
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  214
taaaggaatc atgtctcaaa atacaaactc ccatttacaa cttccagatg actcctttag       60

ctaccgaaaa ggttgaactc tgtagcatgg gcaatattcc tccagtctgt ttatctagtt      120

ttatcttgcc aggcatacct agggttggaa acccagctct gtttatttac atagcaatgt      180

ggctttactg ctttgagaat tattttcctc atctacaaaa tgcaggttcc tcagtgggtc      240

ctcagatgta gacaaataca gagatggcta acgtgggcct gacagtcttt acggagtctg      300

aagggcaggt aaactttcca tggtgatcca tccatcttct agcaaga                    347


<210>  215
<211>  203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  215
taaatatctt cctttcctta accacacgga tattgttttt caaaaggtct aaagggcagt       60

ggcctttggt gcctggaaca cttttagagt atttaggtaa tcaataccct ggttactatt      120

taaccatatt tgaaagagaa tcaagtgagt tctgtgcaaa tcaatgtgta tctgggtgag      180

tttccaacat cagatagatc tta                                              203


<210>  216
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  216
gctttattcc ttcaaggtaa tatagtgcgg tggcttctgg ctgagatgtt tgctgttgtt       60

ttcttcatct tgtctttgat gacttgtcag cctggggtaa ctgcacagga gaaggtgaac      120

cagtaagtgg gccatatgtc tctgcaaaac ttgcacgtag gaatcacctg ctggggaact      180

aagacacttt tatgtttgca gcagaggctg tgttagaatg gaaaataacc tcttttcatg      240

ttattactac tcctgtggag gaggatggga cagtgaaaag accgtgcact tggagtcaaa      300

ttggtctatg tgtaaatcac agctctaatg cttagaagct gaata                      345


<210>  217
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  217
ccacctctgt gaaacccgct ctgatattgc tccacccctt ctcccatagt ttcatctgtt       60

tatacattca ttcattcaac catgtccaca tgagtatcac atgtgaaaag aacaaaatca      120

gtatggtcac tgttcttgca aagcttacga tccagtggag gaaacaaaat aaacagccaa      180

agtccaaata tcatacttgg tcctctttta cttcctggcc ccatcagcga gatatattga      240

ctttacttct aaagcatatg catcacctgt tctccctcta ttactgtctc acttgtccaa      300

gccaccattg tctctcacct ggatactgca agagtatggt ggtctcttat                 350


<210>  218
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  218
catgtctcat acttttgttt tcactccaaa ctgcccagtg aagtaacatt atcccaattc       60

ttcctatgaa acagtgaaag ccctaagagt ttttgaaact ttacctggtt tactcaattt      120

gggaatggca gagcagaatt cagtccttga atatcctccc actgcaggtt catgctcttt      180

gatctaggtg taacatttac tctgagtaaa ctaggactct gggctaacag agatgaagca      240

agacaggctg gatattagga gaatctaaga gcaatctaac gaccattata ataaaatcat      300

gagttctaga cttaaaaaaa gggaaaaacc tgtttttttg cttat                      345


<210>  219
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  219
cttaatttca attcattttt ctgtgtctac ttacaacttt ggcactagaa ttcacaattt       60

ttttttagag gtatatctcc ttaaagggaa gggttctgac actgttacat gttctcaatt      120

gtttgcaaat aggttaataa ttattccagt gtctctaagt acatatcaac catgccagtg      180

ttcagcctcc ataattttat tagcttctgt gcttattttg gaaaaacatt tcccattacc      240

atgaaagacc tcagtttagg atggtttggt atgttagcct gatttctgca t               291


<210>  220
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Synthetic construct; Liver-specific CRE sequences

<400>  220
tcatgaggaa gatgaaaaga cagacccagg cagggatgga aggactgacg agaaccaact       60

tacaaagaga agttttgttt ttactacatt tctatgtgat caagttccca ggttaatatt      120

tgactaaact gctaggaatc cactgtgact ataatgctgg aaatgactta gtagggc         177


<210>  221
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  221
tatgggtctg actccatcac tgatttcagg agccctgccc tttcctccac accatgcccc       60

cttgctttca gaaaaaaagg cttgttgact gaatggttgt atgcacagtt caaagcagaa      120

acacacgatg acatcttttg agatactcta acagtgagaa cttgaaaatg aagttaaaaa      180

ttaagcggca aaaccaagcc gaggctttct gagaaagtgg ggccaaacct gttgccgtct      240

gactgc                                                                 246


<210>  222
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  222
agaacttttt cctgctgcct cttggtgctt ttgcctatgg cccctattct gcctgctgaa       60

gacactcttg ccagcatgga cttaaacccc tccagctctg acaatcctct ttctcttttg      120

ttttacatga agggtctggc agccaaagca atcactcaaa gttcaaacct tatcattttt      180

tgctttgttc ctcttggcct tggttttgta catcagcttt gaaaatacca tcccagggtt      240

aatgctgggg ttaatttata actaagagtg ctctagtttt gcaatacagg acatgctata      300

aaaatggaaa gatgttgctt tctgagagat gcaggtggat tct                        343


<210>  223
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  223
tctcttttct ttgtatttta agcccagtgg gcaaatcctt ttgatccatc caagacagaa       60

gacagttcca gcttcttaat agacaagacc accactgttc aagtgcccat gatgcaccag      120

atggaacaat actatcacct agtggatatg gaattgaact gcacagttct gcaaatggac      180

tacagcaaga atgctctggc actctttgtt                                       210


<210>  224
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  224
ggaattgaaa gtaagccaca gatgagctag agaaggctgc tgataagaat atgttgcaca       60

aattatctgg cttatccagg tgctctgccg tgcgtctaac ccgttgagcc tgtgtgttat      120

ctccacgtga cttaatctgt gagatcttgc cacaggttaa cttgctcgtg tgtacaagag      180

gcggacattc ctttcagtgc agtcggaact actgttgatc aagcagagag tggcagttac      240

tgaagtgtcc ctgcaaagtg gaaacacacc tgttccttat acagttggct ctcctaacct      300

cagatttcgc atctgcagat tcaaccagcc acagatggaa aatatg                     346


<210>  225
<211>  197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  225
taaccattta ccttttggtg ataactattt accttagtca tttctgagga ctgacccaat       60

gctgccctct agtgataaat cttaaaaggg ctgccatgag ctattgaaat gtgatgactg      120

gtgactcttg gagggctgtg taataaggcg tcatccatgt cccatcagct taaaatgagg      180

ggattctgaa tctcttc                                                     197


<210>  226
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  226
ttttgatatt tgtcaacttc ataggttaaa aaaaaaatag gtattttggc acggttttaa       60

tttgcctttc tcttattgag tcagattgca catttttttc atacattgaa aggccatata      120

tatgtttttc ttcgcgaact attcatttcc tttgtccatt gttctattga gtctcctgtc      180

tttctcttac atatttctat gatcacttca taaattagtc tttgtctctg atatgaatta      240

cacatatttt tcccagtttg tcattcttcc tttgacttta tgtggtatgt tttagtggag      300

ttactttcat atttaattta ttcttcactt ttt                                   333


<210>  227
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  227
ggcatgtcct ggataacttt ctgagtcaat atgtgggaac ttcctcattg tcatagctga       60

ttaattctta ctgatgaaca tttgggtgtt tccaatcttt cgcactagaa ataatgttgc      120

aatgaatatc cttgtttata tatcattttg taagtggtta ggtgtacctg aggattaatt      180

cccagagtga tctgagtcaa aagataatca ctttgtgaca gtgctaaaat tgccctattt      240

gtattatttt gcactttcac cagcagagta agagtacttg tttctcacag ccttgcgaca      300

ggaaccacag gcca                                                        314


<210>  228
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  228
gttagctata atagattctg gattgtcaca acagtgaaga gaaagtggaa atccatgaaa       60

taggaccgtg agtaaattac cgtctgatct atttcacacc ttcttctgtc tcaaacccac      120

acacactccc tttccgggag tgtaaggaag actagtagat aagacctgta ccagaacaac      180

ctcagctgac atccactata aaatcactca ttagtgcact attggttcat gccttttacc      240

cttggctgcc tcttgttttt tactcagtca tatttgacct caccaagaca cgactgtgtg      300

gactgctcta ggctggcaca ggcccctctg gagagctgtt gca                        343


<210>  229
<211>  220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  229
taaagtaccc tataagcaac atgacgtact taaaataata acaatagtag taatagcaag       60

gtaggaaaag cctgagatgt ggagccagac atagcaagta caaatgtgca gttactcgtc      120

cctggctgac gctggacaaa tgatgtaatc tcaatgtgtc tccatttcct cagctgtaaa      180

acagattatt ttcaggatta aatgagattg catatataaa                            220


<210>  230
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  230
gacctgtcct cccagatggt ggagatggac aggaggacta tctacccacc cgtccccacg       60

gccctgaccc tctgacctca ccctctccgc tgatttcttc atgttagttc aacattaacc      120

cagaggggtc aggacagaca attcctcagt gacccaggag ctgacacact atggcgcacg      180

tccgaggctt gcagctgcct ggctgcctgg ccctggctgc cctgtgtagc cttgtgcaca      240

gccagcatgg t                                                           251


<210>  231
<211>  158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  231
tgaggccgct gtcccatgac ccccccaccg ccttacagtg ttcctggctc ctcagcaagc       60

acggtcgctg ctccagcggg tccggcgagc caacaccttc ttggaggagg tgcgcaaggg      120

caacctggag cgagagtgcg tggaggagac gtgcagct                              158


<210>  232
<211>  157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  232
cacagagaag caagcgagga acgccacagc cccttcgctg ctcacagcct catttcaact       60

ctgagcccct cctcacaggg ctggcaagag gagcggcctc agcctttcct gggggtctct      120

gtgcctggac tgtgtccctg tgcagctcca tgacatg                               157


<210>  233
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  233
ttttatctaa ttttacgtag caattacgtt ttgtgcattg gttgacaagc ctctgtatta       60

tcctcagaac agaaaatact gtttaaggga aattaagagc ccgcagttac taaagtgact      120

gcgccaccaa gtggacaagt gtaaagccac tgtctggaga tggaaggatt cagctttgct      180

ttataaatgg gaatttgacc tttaaaaatg tcccttttgg cacgcacgcg cgcgcgcgcg      240

cgcgaacaca cacacacaca cacacacaca cacacacaca cacacacacg gctgctgccc      300

tgcagatttg cttgttcttg tcataaagct ttcattgttt ctctagctct a               351


<210>  234
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  234
aaaagaagga ttaaatattc atttatcctt ttgcttctga cttgttatgt gggcaagtgc       60

cacatgaggg agtgctggga cctcatatca agaaaaatta aaacctacct aatgcgttcc      120

aggaatgttc agcatattag caaattctta ttaaactgt                             159


<210>  235
<211>  213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  235
taatgccttc caaggctggc atgccaatgg ctgctattaa gatcgttttc tctcattcta       60

ataacacact tagagatgat tggtaataaa aactctcttc aaggcttctg cttctccccc      120

ttcaaaatgg agatcaaaga atcatgctgt gagggtccgt caagaagaaa agactttcag      180

caacagagca tgtggtgtgg cataaaataa tga                                   213


<210>  236
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  236
ttaaaagtaa ttgcctgaag ctgctgttta tcacataaaa agaagacaaa ctagacatag       60

catatcttct taaactctaa tctaaactct atgcatttgt ataccatctt gattttcaag      120

attggggaag tgaaacgaaa actatgttca cacaagaacc tgtacgtgaa tgtttgtagt      180

ggctttattt agaatttccc cccaaactgt aagtattcaa aatgtctttt agcttgggaa      240

tgactggaca aatgatagta cccctgtatg atggaatatt attcatcaac caaaaggaac      300

aaactattga cacgtacaac aacatgagaa                                       330


<210>  237
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  237
tcttagtatg acagtaaatg cttatgttca tggtgtagga aacagcatta aatgccagat       60

aaccatctta tccggatgaa ccagactgga ttgttggctc aaatgttttc ttcctgctgg      120

cttttcgtgt tatcattcat tttgattact gttgtctaaa ctttcacttt agatttcaat      180

ttgtctatgc agcattaatc tttcaacttt gctgtttcat ctctccttca aagcacttca      240

tctctcttcc caaattagtt ttcctttgac tttcatattt caaag                      285


<210>  238
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  238
gttatgatag tttctttttt atagtaattg cacaggggaa gagctaaagg atagaactct       60

gtcattgtga accctgaaag ctcagaaaaa ggggagggaa atgagcctca aggtgatgac      120

cagtaaccaa taaatcacgt cactctgccc tttgacaaac atttctttat ccatggctcc      180

ctcagtcccc tgaatgcgaa attgctttga ggagattgt                             219


<210>  239
<211>  166
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  239
tagtcagcct ttcctccttt gctcagctgc tctgattcag agctactctg attttactct       60

ggaggacaca tgcaaccaat gtctgaacag tcatactcaa tccctgcatt gaggtagaaa      120

gcactgattc ctagaggctg atctgaatca tgcaactgta ttgaag                     166


<210>  240
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  240
acttaattga ataaacaagt aaaagccatt cccaaaagta aggtttactt gttaagatta       60

acaaaaaata atgtgagaat tctgagaaat ataatcttta aatattggca actggagtga      120

actcttaaaa ctaactaggt tttatatgtt tgactagagc aatgacataa taaggtggtt      180

aatcatcact ggacttgttt tcaaaaagcc aactacttta agaggaataa agggtggact      240

tgttgcagtt gctgtaggat tctaaatcca ggtaagaacc attgagattc tctaattttt      300

acatatattt ta                                                          312


<210>  241
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  241
ggctcacctt ctctctgggc aaacaagttg ggaacaagtt cttcctgacc aatggtgaaa       60

taatgacctt tgaaaaagtg aaggccttgt gtgtcaagtt ccaggcctct gtggccaccc      120

ccaggaatgc tgcagagaat ggagccattc agaatctcat caaggaggaa gccttcctgg      180

gcatcactga tgagaagaca gaagggcagt ttgtggatct gacaggaaat agactgacct      240

acacaaactg gaacgagggt gaacccaaca atgctggttc tgatgaagat tgtgtattgc      300

tactgaaaaa tggccagtgg aatgacgtcc cctgctccac ctcccatctg                 350


<210>  242
<211>  157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  242
tctgtgagtt ccctatctga agggtcatat cactcaggcc ctccttgtct ttttactgca       60

acccacaggc ccacagtatg cttgaaaaga taaattatat caatttcctc atatccagta      120

ttgttccttt tgtgggcaat cactaaaaat gatcact                               157


<210>  243
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  243
ggtcccattt gttctcactg ccaccgaaag catgtttata gtcttccagc agcaacgcca       60

ggtgtctagg cacagatgaa cccctcctta ggatccccac tgctcatcat agtgcctacc      120

tttgttaaag tactagtcac gcagtgtcac aaggaatgtt tacttttcca aatccccagc      180

tagaggccag ggatgggtca tctatttcta tatagcctgc acccagattg taggacagag      240

ggcatgctcg gtaaatatgt gttcattaac tgagattaac cttccctgag ttttctcaca      300

ccaaggtgag gaccatgtcc ctgtttccat cac                                   333


<210>  244
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  244
ctttaccttc cagaggaaac tgcctgggga tatgaggaga ctgatgtcct atttgagtat       60

atttttctca actatactgt aactcaaaac agagattcag ctctcattct ctggcatctc      120

agaattccac acagcagttt gtgactaata gttgtcttgc cagcccagga aagtggccca      180

caggtcaggc catcccgtgg gacacaggat gaatttttct tctctgggtc attgtcatgt      240

cagaccccta ttcacttcag tagggatggc accaggttca agaggccaaa gaagagatgg      300

agtcagcaaa ca                                                          312


<210>  245
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  245
tgcctgatta ctacaaacca agtgcacaca gggtctcatg atctgggcct tggttatctt       60

ctcaggttta tctcctcccc tgccacattc actgtgtgcc agccatacga atctacatga      120

ggttggagca cactgcttcc tcatgtttgg gctctgcatg ctgctccctc tgctggtaac      180

accctttcct cacttgtcaa cctggaaaat tcctgctgat ttttcagctc ttgggcccaa      240

tgcttcctct ttggtgtgaa accttccaca acttctctag gcagacttag gcactctgtc      300

tatattctca gtgcactctt tacactacac cttggtagtt gcatggct                   348


<210>  246
<211>  271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  246
gggttggtag tgatgccagt agtgatggtg atagtggtag tgatggtggt ggtggagcca       60

ctatgtggct ttttaaggaa gggaaataga gaagccacgt atggtctaga ggtcacgtga      120

gggaaggaga ggaagtcatt ctggtgaagg caactgtgtg taattctgtg tgaatagtcc      180

ctcattgttc cccatgaccc ttaggacaaa tctaccctct ttagtcttac atacaagtct      240

ctccatggcc aaatccctat tggcccttca g                                     271


<210>  247
<211>  344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  247
ctaaaatgtt caagtgggaa attacagtta aataccatgg taatgaataa aaggtacaaa       60

tcgtttaaac tcttatgtaa aatttgataa gatgttttac acaactttaa tacattgaca      120

aggtcttgtg gagaaaacag ttccagatgg taaatataca caagggattt agtcaaacaa      180

ttttttggca agaatattat gaattttgta atcggttggc agccaatgaa atacaaagat      240

gagtctagtt aataatctac aattattggt taaagaagta tattagtgct aatttccctc      300

cgtttgtcct agcttttctc ttctgtcaac cccacacgcc tttg                       344


<210>  248
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  248
tctttgcccc tattttaggg ataaggattc tgaaatgtgg agatggtaag taaaattgca       60

caactgaaga atgagttaca tgacttggct caaatactgg tcattgaact ccagagcctg      120

aatattctta accacttaca tgatgcaagc tcaccaaata aatagttcga atgtattgtg      180

acagagcggc attgatattc atctattcat gtggctttga gtaggaagaa gaaaggatat      240

cattctgacc agaggggtga aaaacaacct gcatctgatc ctgaggcata atactattaa      300

cacaattctt ttatgtttca gttcgatgaa tttaaacctc ttgtggaaga g               351


<210>  249
<211>  280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  249
tgcaacatta atctaaaaac ctcaatgacc caaatagaaa aggaaaaaag ctttctgaac       60

agccaaacag agattccaaa gttcaggcac caaagttcag accctaacag ttatttacaa      120

gggtcagtta accttttgtt ctagtgggat aggattccca tggtgagatt tgaagaactg      180

tggaaccact gtttcaggtt ctttttccac tttgccaccc gtttgaaatt ccatccatta      240

ggaattaact ggcatgatgg gagtcccttt tataataaaa                            280


<210>  250
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  250
gagttcaaga ccagcctggg caagtctctt taaaaaaaac aaaacaaaca aacaaaaaaa       60

ttaggcatgg tggcacatgc ctgtagtcct agctacttag gaggctgacg taggaggatc      120

gtttggacct gagaggtcaa ggctacagtg agccatgatt gtgccactgc actccagcct      180

gggtgacaga gtgagact                                                    198


<210>  251
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  251
ctctattttt aaacttctcc cacaaagatg agaaaacatt taaaaatcat tggggctatt       60

tttctgttta ccgagtaaag agaatctcta aaccatattt ataactctta ctctaaatat      120

ttgcatttac cctcatgcca gagcccgttg atgactgact aaacagagtt tcaaagtttg      180

aagaacagga aatttagaaa tgactaacaa ttatgtaggt tta                        223


<210>  252
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  252
gtgaacaaaa gaacaacccc tgaatggaca gatttgtggc tgttagttta atttggctaa       60

tcaagaagca actgcaccaa tgtagtaagt ggccatgagc aagtttctct acaacaaaaa      120

acattgcttc acagggtggt tgagtcactg gaaagatttt catatttaaa ctcctttagc      180

atcccctttg tctactcacc taaaccaaat acaaaataat atcaatggga attagtactg      240

gtttgggact tggatttgag tggggaggc                                        269


<210>  253
<211>  152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  253
ctacactctc gtttcttctt ttaagatttg ccaatgatga tctgtcagag gtaatcactg       60

tgcatgtgtt taaagatttc accacttttt atggtggtga tcactatagt gaaatactga      120

aacttgtttg tcaaattgca cagcaagggg cc                                    152


<210>  254
<211>  213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  254
ctcagggcac tgtgtgggag ggtgagaagg agggaggccc acagaggcat gacctctgat       60

tgccactgtc acctgggccc tgctctctga agtctctgcc aagcggggag gtggccgggg      120

gagggccctg ctctgtgcag cctcccctcc cccggcccgc agagttgagc acagagggac      180

agaggcacgg aacccccaga aatgtccctc ctc                                   213


<210>  255
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  255
ggcaccattc catgtgcatc gtatgtagta actcttaatt ctcacgataa ccctgaggta       60

gatattatta ccccgttcta caaaaggaga aacagtcctg gggagacagg ataagtcacc      120

ggccaaggca cacagctagc tacatgtggc ccccgcgtga cggctggtct ctgtaggcga      180

ggctttgtcc agatgcgtgg gtagaaggtc tggcccggaa agaggaactg acagcaaggc      240

taagccaatg tctgcccctg ggggcagaaa gtcacctcct gctctccctc cactgtccac      300

agaggtagct cagacagggt gggggtcaca ggagaacgaa gggagaa                    347


<210>  256
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  256
aagcagcaag agtgagatga gtcgtcaggt aaatcagccc tcgataaaat agcaggaacc       60

tgttcaccca aaactgaaat gagtcgtcag gtaaatcagc ccttgataaa acagcaggaa      120

cctgttcacc caaaaccaaa atgagttgtc aggtaaatca gaccttgata aaatagcagc      180

gcctgttcac ccgaaaccga aatgagtcat caggtaaatc agccctggat aaaatagcag      240

gaacctgttc cgccgaaacc aaatgagtcg tcaggtaaat cagcccttga taaaataaca      300

gcacttgttg accagaagcc atgggaccag caggcagtga gatgacaca                  349


<210>  257
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  257
agatcaggat tagggcgatg gcccccgcgc gttgcctgcg gagcgaggcg cactgagtcg       60

cccaggaatc cggcctctcg gcgactgtgc gggagagttt atggggatgg gcggggctgc      120

ttctgagcag gagtcgccgc ccccaccccc accgttccgc ctctgggccc gcaggctcct      180

cccgggagcg ctttcccctc ctgttcaacc gccggggtac aggtggcttc gtccaccgag      240

gtcccctcac ccacgctgag gcgtcggaag ctgcggacac tgctcgcttc agggctttgc      300

tcagct                                                                 306


<210>  258
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  258
gcaggcgcct cccaggagtg gtcagtggtc aatcagctaa tgaagctgca taggacatga       60

cccttgttta ccgcagaatg cccagagctg gcaggatgtc ttatatgcag gaagtaccca      120

aaatgtattt attgaggaag tgatgatgga taagaggaag acggagagcg agggagagag      180

gggctagggg cccctgcggt gtaaaggggg tgtggctggg agtgtgcagg ggaacaggga      240

tcatttcaag gttcctatct gggagaaaat aaaaaggttt acagttagtt gagataagcg      300

tgggaatatg cgaacatttt taaagaataa aaagtttagc tttaaatttg                 350


<210>  259
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  259
ataaagaacg ccgtcagcac agagcagacg ctgggtgttc gcgctcttga gcgtgcgctc       60

tgcggggcgc gggctggtgg cgggcggggg tcgccggctc cagctcaggt tcccgcgcca      120

ggaccgcgtc cagaaccttg tctccggaag cgggcaacgg ggtggttgta tcacaattag      180

tggcatttgg ttttccttct tctgcattgt gggttttact tctctggggt tg              232


<210>  260
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  260
gctggtgacc tccagagagg gagtctctga tgtcccgctg gggtggatgt cctgagaccg       60

ggaaggggga agagacccac tgaaatccta tctcccagcc tcacctctgc tgtctcctcc      120

acgcttcctg tctccagagc cccgagttca gcataagcag aaagcggcct gttccctctc      180

tagggagagg agggttgcgg tctggaggtc tggctcgtct ttatctgcgc attctcccag      240

cctcctggct tcagacctca gcgaggcggc ggctgccggc cggctctcct cttcctgcct      300

gcagacctgg cctgctgctt ctttctcctt cctccctccc tgcctgcc                   348


<210>  261
<211>  173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  261
tggcaccaat acctgccgcc tacgactgtt gtgaacactg aatgggccaa caaacctaaa       60

cgttaaatga actgataacg ccgtcagcac ggagcaggcg ctgggtgttt gcgctcttgc      120

gcgtgcgctc tgtggggcgc aggctgacgg cgggcggggg tcgcctgctc cag             173


<210>  262
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  262
ctcgccgcgc ggcgggcctg acttctagcc acgggtctcc gcagttggcc cagcgcttcg       60

ggccggtgtt cacgctgtac gtgggctcgc agcgcatggt ggtgatgcac ggctacaagg      120

cggtgaagga agcgctgctg gactacaagg acgagttctc gggcagaggc gacctccccg      180

cgttccatgc gcacagggac aggggtgagt ccgcgtcc                              218


<210>  263
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  263
gagcagagca gctggaaccc cccgagcgcc ctgcagacgc agcagcctct tgaggggagg       60

gtctccccca cctcgggctg gacaaagaca gcttttcccc acgtccctct gggttctcta      120

gagcaacagc aatacccgcc cggcaggggt g                                     151


<210>  264
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  264
gaagattagg gctttcatct tcatttagac ctgacccctg actgctttct atctaatcct       60

tcactaagca actccttcaa ctggaaatat actatcctat atagcataat attcaaaact      120

acattcttca ctgggggttt ccagatgaaa gcccacattt tgttaacatg actcactgag      180

acagtctttg tttctcctag ggcacagtcg tagtgccaac tctggactct gttttgtatg      240

acaaccaaga atttcctgat ccagaaaagt ttaagccaga acacttcctg aatgaaaatg      300

gaaagttcaa gtacagtgac tatttcaagc cattttcca                             339


<210>  265
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  265
ggagtgggct gcctggggtt catacgtcac cacacttgat aatttacaga agcctttcac       60

gcgttttttc ctgtgtctca aacggggtac caggaggctc agggaaacag cgcaggcgcc      120

tccccggtgg cttctctctg gcgccctctg gtgggcgggg cccgggtgag cggggtcccc      180

tcggggcctc agggagccgc agccccagcg gaaccaggag ggcgccctcc gcccagccgc      240

gctgccactt ccgggttgtt tgctcccgga gccataaccg cagctcagcg tgcgggcaga      300

gccggctgac aggagacagg acacagca                                         328


<210>  266
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  266
aaatcgttct ttgtcattac ccatcccagg ttgtcctcct gtctccttgt ggtgaacatt       60

ggcctgtgac cctgttttat gattaacaga gaggtgacat ttgtgctaac gtggtacaga      120

cctttaatcc cactgtagaa gtttaactcc ctgtaa                                156


<210>  267
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  267
ttatagaagg ggatggtatc cccagcaata ttcagcaaca ttgctgtaaa aagaagaaaa       60

tctgagtgaa ggtttgactg gtttcccatg agaggcagac agggtcaagg tggggtcaca      120

tttactctaa ccagtctcct ctctcatatt tgtcttctag gctaactgcc aggcggccaa      180

aggacagtat gttcacacgg gttcttctgg ggctgcttcc acccagtcgc tcttcacagc      240

ctgctatacc tactagggtc caatgcccgc cagcctagct ccagtgcttc tagtaggagg      300

gctgaaaggg agcaactttt cctccaatcc tgg                                   333


<210>  268
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  268
gcctggggtc ccggcttaga ggacctctga gagctccggg gccccttctg ggtcgtggtt       60

gcctcatcgt ggtcgggtgg gtctccaggt tctcccaggc tcagtcccgc aggcgccaaa      120

tctgcgcagg agagcactag caaccgatga cgtattgagg cccacacctc tgggattggc      180

tgtcctgctt cgacagcctt gaaagtgggt aagctgggtg gggggctctg ggagaggtca      240

gtgctgagta aggcaattcc cagcagcttg agccccacca ggtcactcca gtattcctcc      300

ccattctttt tttttttttt tttttttct                                        329


<210>  269
<211>  161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  269
cctgggaggg acacccgcct acactctgca agaaactcaa aaagggagat gaggggatcg       60

tgggagggag gtagggaggg aggagggtgc cactgatccc ctgaacccct gcctctgcct      120

ccagagtgcc cctccggcct cgccatgagg ctcttcctgt c                          161


<210>  270
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  270
agagttgtga gcccttaaaa ggaacaggga ttgctcactc ggggagctcg gctcttgaga       60

caggaatctt gcccattccc cgaacgaata aaccccttcc ttaactcagc gtctgaggaa      120

ttttgtctgc ggctcctcct gctacattct gagtggggaa agggactaag gtggtctgag      180

gaccccacag agtcaggaag a                                                201


<210>  271
<211>  253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  271
gagagtgctg aacggggagg ggctttgggg ctaagggaag tgcccgggac cccacctgac       60

cccaacgctc acgggacagg ggcagaggag aaaaacgtgg gtggacagag ggaggcaggc      120

ggtcagggga aggctcagga ggagggagat caacatcaac ctgccccgcc ccctccccag      180

cctgataaag gtcctgcggg caggacagga cctcccaacc aagccctcca gcaaggattc      240

aggttggtgc tga                                                         253


<210>  272
<211>  286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  272
agggaggaga ccacccctca tattgtctta tgcccaattt ctgcctccaa agaaagaaaa       60

agtaaaaact aaaaggcaga aatgaaatcc acaagcagac agcccgcgcc acaccctggg      120

cctggtggtt aaagattgac ccctgaccta atccgttagg ttatctatag attacagaca      180

ttgtatagaa aagcactgtg aaaatcccta ttctgttttg ttccgatcta attaccggtg      240

catgcagccc ccagtcacgc atcccctgct tgttcaatcg atcacg                     286


<210>  273
<211>  202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  273
cggagtctcg ctctgtcgcc gaggctggag tgcagtggcg cgatctcggc tcactgcaag       60

ctccgcctcc ctggttcacg ccattctcct gcctcagcag gactacaggc gcccgccacc      120

gcgcccggct aattttttgt attttcagta gagacagggt ttcaccgtgg tctcgatctc      180

ctgactttgt gatccgcctg cc                                               202


<210>  274
<211>  341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  274
attttgaacc cctgcccatc ttcctggcag gcccagcccc agcccagggg accccagacg       60

tctccagtgc cttggataag ctgaaggagt ttggaaacac actggaggac aaggctcggg      120

aactcatcag ccgcatcaaa cagagtgaac tttctgccaa gatgcggtta gaacccttcc      180

cagggcacgg gagagctggg gtgtgttttt gggtggagcc ctggcagatg gtccaagatg      240

aacagattga aaaaaaaaca agtcctggag aggctgacaa catccctctg gtcacacagc      300

tagatctcaa ggtgctcaga cttcaaggac agtttccctg a                          341


<210>  275
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  275
tgagaaaacc gacctctaag agaacttctc agagaagctc aaaaggtgta tgtgaggagg       60

gacagggaaa aacaaaaaca gaagtcaaaa ccaatgttat ctactttcca gcaggtggct      120

ccaaacccat atgctactaa atgaggcttc cagggagcca gaaactataa aaggtcccaa      180

gcctcccaaa cccagtttag agaaaccaaa ccttcagcta gaggacccaa gtctacattt      240

cccag                                                                  245


<210>  276
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  276
aattcttctt caaaggttca gcttgcttaa gtttccttgt tctttgctcc ctgctttcaa       60

ggccagactt ccttactctc tgtgttctcc ctgcgctggt aaacaacctt cccgccagtc      120

gttatctata gagcccacat tccacatctg ctacccactc tgtgaattac ccctcccatc      180

acaatggctt ctcccggcaa aactgatctt cctgccttcc cagcagtgta atcacattcc      240

tgcacttttc aagttagcca accgggttca gcttagattg tacggtccaa ctctagccaa      300

tggagtcagg atacagtagc agggacaagc tgcgttagac ataaaaacct                 350


<210>  277
<211>  241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  277
aaattctttg gcaaatggaa gggatttatg tcctcaatcc tcatgtctct tgccatcaga       60

atagggttgc ttattcttgt aggatgctgt gtcataccct gtgccctagg attaatacaa      120

aagctcattg aaacagctct ccccaaaacc tccctcaatc ctcctcctcc tcgttccagt      180

gagctttttc ttttagaaga cccaagtaga ataacagagc caaattatgt taaaagggtt      240

t                                                                      241


<210>  278
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  278
ccctctgcag ctggccccag aaacctgcca gttattggtg ccaggtctgt gccaggaggg       60

cgaggcctgt catttctagt aatcctctgg gcagtgtgac tgtacctctt gcggcaactc      120

aaagggagag ggtgacttgt cccgggtcac agagctgaaa gggcaggtac aacaggtgac      180

atgccgggct gtctgagttt atgagggccc agtcttgtgt ctgccgggca atgagcaagg      240

ctccttcctg tccaagctcc ccgcccctcc ccagcctact gcctccaccc gaagtctact      300

tcctgggtgg gcaggaactg ggcactgtgc ccagggcatg cactgcctcc a               351


<210>  279
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  279
ccgaggaagg cctagccgct gctgctgcca ggaattccag gttggagggg cggcaacctc       60

ctgccagcct tcaggccact ctcctgtgcc tgccagaaga gacagagctt gaggagagct      120

tgaggagagc aggaaaggtg ggacattgct gctgctgctc actcagttcc acaggtggga      180

gggacagcag ggcttagagt gggg                                             204


<210>  280
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  280
acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact       60

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      120

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      180

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      240

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      300

agt                                                                    303


<210>  281
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  281
tggccccaaa tcacacacca tccataattc gggctcaggc acctggctcc agtccccaaa       60

ctcttgaacc tggccctagt gtcactgttt ctcttgggtc tcaggcgctg gatggggaac      120

aggaaacctg ggctggactt gaggcctctc tgatgctcgg tgacttcaga cagttgctca      180

acctctctgt tctcttgggc aaaacatgat aacctttgac ttctgtcccc tcccctcacc      240

ccacccgacc ttgatctctg aagtgttgga aggatttaat ttttcctgca ctgagttttg      300

gagacaggtc aaaaagatga ccaaggccaa                                       330


<210>  282
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  282
agagtgaggc cccaggacca gaggattctt gctaaaggcc aagtggatag tgatggccct       60

gccagggcta gaagccacaa cctctggccc tgaggccact cagcatattt agtgtcccca      120

ccctgcagag gcccaactcc ctcctgacca ctgagccctg taatgatggg ggaatttcca      180

taagccatga aggactgcac aaagttcagt tgggaagtga aagagaaatt aaagggagat      240

ggaaatatac agcactaatt ttagcaccgt ctttagttct aacaacacta gctagctgaa      300

gaaaaataca aacatgtatt atgtaatgtg tggtctgttc catttgga                   348


<210>  283
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  283
tggccagttt cctatagaac gcctctaaaa gacctgcagc aatagcagca agaactggta       60

ttctcgagaa cttgctgcgc agcaggcact tcttggcatt ttatgtgtat ttaatttcac      120

aatagctcta tgacaaagtc cacctttctc atctccagga aactgaggtt cagagaggtt      180

aagtaacttg tccaaggtca cacagctaat agcaagttga cgtggagcaa tctggcctca      240

gagcctttaa ttttagccac agactgatgc tcccctcttc atttagccag gctgcctctg      300

aagt                                                                   304


<210>  284
<211>  259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  284
ctcaattttt ctatctataa aatagggcta ataatttgca ccttataggg taagctttga       60

ggacagatta gatgatacgg tgcctgtaaa acaccaggtg ttagtaagtg tggcaatgat      120

ggtgacgctg aggctgatgt ttgcttagca tagggttagg cagctggcag gcagtaaaca      180

gttggataat ttaatggaaa atttgccaaa ctcagatgct gttcactgct gagcaggagc      240

cccttcctgc tgaaatggt                                                   259


<210>  285
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  285
tgcagatggg aaaacaaagg cccagagagg ggaagaaatg cccaggagct accgagggca       60

ggcgacctca accacagccc agtgctggag ctgtgagtgg atgtagagca gcggaatatc      120

cattcagcca gctcagggga aggacagggg ccctg                                 155


<210>  286
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  286
gcagatggag aggctgcagc tgagctccta ttttcataat aacagcagcc atgagggttg       60

tgtcctgttt cccagtcctg cccggtcccc cctcggtacc tcctggtgga tacactggtt      120

cctgtaagca gaagtggatg agggtgtcta ggtctgcagt cctggcaccc caggatgggg      180

gacaccagcc aagatacagc aacagcaaca aagcgcagcc atttctttct gtttgcacag      240

ctcctctgtc tgtcgggg                                                    258


<210>  287
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  287
aactcttcac tgtgaaagga ggaaaccaga gtaggtgatg tgacaccagg aaagatggat       60

gggtgtgggg gaatgtgctc ctcccagctg tcaccccctc gccaccctcc ctgcaccagc      120

ctctccacct cctttgagcc cagaattccc ctgtctagga gggcacctgt ctcatgccta      180

gccatgggaa ttctccatct gttttgctac attgaaccca gatgccattc taaccaagaa      240

tcctggctgg gtgcaggggc tctcgcctgt aaccccagca ctttgggagg ccaaggcagg      300

cggatcaaga ggtcaggagt tcaagacctg cctggcc                               337


<210>  288
<211>  317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  288
ttatttcttt agcctcacca gcttcctttc aaatgcgtgg ctaatggctt ccctatcagg       60

cagtgcagac tgaagaacat ttccatggtt actgagagtt ctactcagca cttctgttgt      120

gaaggattca ccttccccaa gctgtgtgcc acatttcaca cagcaggtgc acagggatgc      180

cagctctctt ttttccaccc cttctcttta ctctcctctt ctttgcatca ctcccctctg      240

attcacttct cttcctttcc cccttccctt cctgtcccct tcctacttca gaacagaaca      300

ggcaacctat ttcacct                                                     317


<210>  289
<211>  237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  289
attttataaa tataactttt tataatattt agaccttttc ctttgagcaa aattagtaaa       60

gtgttcttac agtagcataa gtcagaaaag caaaacaaaa caaaaaccct tgtatctcta      120

gggggcatag gagaccagga tctaaatact tcgaaaaggt tttcaggtta acaatatgtc      180

catttcgaag tcacatgtta actttaattc taaatttatg ctagaatcca ttcctaa         237


<210>  290
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  290
gtctgcaggg cttctgtgct gggcccatac aggttacaag cctcccccca tctcagaccc       60

caagagtaca ctccatttac aaggtggagg aggtagttaa gccctgggcc tcaggagaga      120

atgtctattc ctacgcatgc caaaaccaca tctgtaggaa cttaagcatt ttctgctgtt      180

gtgtcattct cattgttatc gtggtgattg ttgtaaaaac tgctatatga gccttggaaa      240

catgaagcta agtcagaaaa aaaatcagat acaaaaagtc atatgttgta tgatttcatt      300

tatgtgaaag gtccagaata ggcaaatcta ttagatgaac tgctagcagg g               351


<210>  291
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  291
actgatttaa ccttacacgt ggctcccaag gtcaccgaag cagaggagga gagagctgga       60

atgtcttacc aaggcttctg tgaccatatc tggaaggaac atatatcact gctggcctca      120

tctcattgcc caactggtcc catggcccca gcctcacggc aaaggggctg g               171


<210>  292
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  292
aatatcattt gcattttgca aagggagaca ctgagtttca gacagctgct tttgcacagt       60

atgaggcagt gagttactgc acagccttga ttccaaggtc ccctcattta caattgaatc      120

ccctttggga aataggtcat ttgcaagtca gggagtccct ggggtgcagt ggagtagaaa      180

atggtgctga gttcaatggg ataaaaagaa taaaccagaa atagtttcat tacaggcact      240

tcattttacc caggggtaga acaattttta aattgatttg catcttccaa attttcgatc      300

aaaagaaaat ctgaagtgta tggaagctgt cat                                   333


<210>  293
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  293
cccacattgg gagttcactg gggctgtcat taagtgaacc cacactgtgc tggagaaagg       60

gaggacgtag ccttgggggc gtgcccacag tactttgacc agcaaacgca tttcaacata      120

gcagataatg agaccacatt cgtccctcct gacacctggc ctttgtcgtt tggcaggcta      180

cttagggcac caggggctac aaacccattt gcaaaaata                             219


<210>  294
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  294
ggatcataca accacagaca caggcaacag ccacaaccac accaccacct gctgccagca       60

tcagaatatt ctcaaagcga gcctgggctt aagtcacaat ccaccatttg tttgtgggac      120

aggcagtcag ggcagatact ttgaaaaaaa agagcccttc ctgtttgctg tgcattgtct      180

tcataccagt tcccagaatt gacctgacaa atattgacca ggttgctgtc atcttcaaac      240

accattttcc tgtgggtaga ggtgatgcag tgctgaagac ctgggcccct gctcagtgcc      300

tttgctctgt aagtactttg cctgtgccca aaatgagggc aggggca                    347


<210>  295
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  295
ccctgcccag ccccaaactc gaactaaaag taggaaactc cctgttccta gacaagcgac       60

taaagcctcg gcagcactat ttggacagca tcaaggagct ttatggagct tttgcttttt      120

ctgccaactt cacagattct gttacaactg ggaggcagat taatgactat ttgagaaggc      180

aaacatacgg gcaagtcgtg gactgcctcc cggagttcag ccaggacacg ttcatggttc      240

ttgccaatta catcttcttc aaaggtgagg cttgctctga cagaattatt gccactgcct      300

ctgcaagtaa atgctcttac agcagagagc cagct                                 335


<210>  296
<211>  209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  296
attctgggtg cttcaagagc tttcgggagc ccagctgttc cccaactaaa ctccagcagc       60

atccctccac caggcattga gctgatccaa aatgtcacct ctatctcctt tacacacagc      120

cctccccctg cctttgtcag gagccagtgt tacaatgcat gtaatatcct atcacttcat      180

aaacccttaa taagtgagaa tattatact                                        209


<210>  297
<211>  329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  297
cttcaggttt tcaatctcct tttatggaaa acttcaagaa ttttgagaga agaatcccaa       60

atattcctgc cagttagaca agaaaatgaa acaatacaac ccaaagcaca atgacaatga      120

tgctgcagca aatttactag aagctgtcct gtgaaaaggg tgcttaggag ctctggtctg      180

gaatctgagt cttgctcctg ctctcaccag gcggcttgtc ctaaccctgc atcagtcatt      240

ccctgtgtac agtagggcta ataatccctg tgctttgagg ttctcataag gattaaatta      300

aataagacaa agcaagtgtt tctcaacaa                                        329


<210>  298
<211>  256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  298
gaatggaacg gtggaagagt tggatttgaa gggagaagag aaggctgcct tccttactga       60

gaaaatcaag atttgggagg gtcccagtag caatgtggtc atgagtcttc tgcaagaacc      120

tgaagatggg tgtagggtcg ggggatggga ctgaaaggga aaggagagca tggaacattg      180

ggcagggtga gtagagacaa ccctgtttgc actgcagttc cccctccagc tcaggctgca      240

ttcccagccc taaaac                                                      256


<210>  299
<211>  169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  299
gaaaataaat accttgatga cccaatttgg aaaactactt ctagataagg aaacactatt       60

acccaatatg ttaattttta aaatacccaa agaattgagc aaaaaggact ttggcaaggc      120

aggttgttgg atttaaaacc gttctcccat taatgccaaa gccagcaga                  169


<210>  300
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  300
gaagatagtt ggaggccctc aaacttacct cctcaaggaa atctgggctg gagtttttaa       60

ggggttaatg gagggtgatg gactgaaaaa ttggagtcat agattagtca ggataatgaa      120

gataaaatca gtaggagttg gaaactgcat tctttggtga gtcagctcct tgtggggtcc      180

ttgagagcag ctggcatcag ggaggtccct cagaccagct gagtcagtag tttcatcagt      240

atgctggacc tgaaggaata cctcaaagag aaaaccacat ttcaaaatgt ttaagttatt      300

atctatagaa cagttaagat gaactttaat ctt                                   333


<210>  301
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  301
ttaaatttta cacaataatt gataatttgt atgatatctg aattatacgt caacaaattt       60

acaaaagttt ttgaaccaca tttagctatt ttatctttag ttctgtgtca aagagactgc      120

aggaacatga gcctctcact gctactctta tgcacactat tctgaaatat attacatgag      180

tcaggtgatg agtccatcca agatcattga tattagctga attacagcac ttaaaaatct      240

agggctgggt gcggtggctc acgcctgtaa tcccagcact ttgggaggcc aaggagggca      300

gatcacaagg tcaggggttc gagaccatcc tgccgaatac agtgaa                     346


<210>  302
<211>  295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  302
gaggggtcct gcaacatctc agtctgcgca gctggctgtg ggggtaactc tgtcttaggc       60

caggcagccc tgccttcagt ttccccacct ttcccagggc aggggagagg cctctggcct      120

gacatcatcc acaatgcaaa gaccaaaaca gccgtgacct ccattcacat gggctgagtg      180

ccaactctga gccagggatc tgaggacagc atcgcctcaa gtgacgcagg gactggccgg      240

gcgcagcagc tcacgcctgt aattccagca ctttgggagg ccgaggctgg ctgat           295


<210>  303
<211>  349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  303
aggctgttgt tacctaggtc cgactcctgg ctcccagagc agcctgtcct gcctgcctgg       60

aactctgagc aggctggagt catggagtcg attcccagaa tcccagagtc agggaggctg      120

ggggcagggg caggtcactg gacaaacaga tcaaaggtga gaccagcgta gggctgcaga      180

ccaggccagg ccagctggac gggcacacca tgaggtaggt gggcgcccac agcctccctg      240

cagggtgtgg ggtgggagca caggcctggg ccctcaccgc ccctgccctg cccataggct      300

gctgaccctc ctgggccttc tgtgtggctc ggtggccacc cccttgggc                  349


<210>  304
<211>  154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Liver-specific CRE sequences

<400>  304
acacctgacc ccacagctga gctcgggggc caaggtgctg gccacgctgt gcgggcagga       60

gagcacagac acggagcggg cccctggcaa ggacactttc tactcgctgg gctccagcct      120

ggacattacc ttccgctccg actactccaa cgag                                  154


<210>  305
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; poly A

<400>  305
aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca           56


<210>  306
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; 5' ITR

<400>  306
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  307
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; 3' ITR

<400>  307
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  308
<211>  3005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; 5'ITR-ApoE.hAAT promoter- chimeric intron - 
       leader-VH-4GSx3 linker-VL-9G linker-Fc-polyA-3'ITR

<400>  308
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac      540

agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac      600

tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg      660

tacaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg      720

ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc      780

gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat      840

ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact      900

gacctgggac agtcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa      960

actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac     1020

tgacatccac tttgcctttc tctccacagg ttgaattcgc caccatgtac agaatgcagc     1080

tgctgctgct cattgccctg tctctggccc tggtcaccaa ttctgaggag gtccagctgc     1140

ttgagagtgg tggtggactg gttcagcctg gtggcagcct gagactgtct tgtgctgcct     1200

ctggcttcac cttcagccac tatatcatga tgtgggtcag acaggcccct ggcaaaggcc     1260

tggaatgggt gtcaggcatc tacagcagtg gtggcatcac agtgtatgct gactctgtga     1320

agggcagatt caccatcagc agagacaaca gcaagaacac cctgtacctg cagatgaact     1380

ccctgagagc tgaggacaca gcagtgtact actgtgccta tagaagaatt ggggtgccca     1440

gaagggatga gtttgacatc tggggccagg gcaccatggt tacagtgtcc tctggtggag     1500

gcggttcagg cggaggtggc agcggcggtg gagggtcgga catccagatg acacagagcc     1560

cctccacact gtctgcatct gtgggagaca gagtgaccat cacctgtaga gccagccagt     1620

ctatctctag ctggctggcc tggtatcagc aaaagcctgg caaggcccct aagctgctga     1680

tctacaaggc cagcacactt gagtcagggg tgccctccag attttctggc tctggatctg     1740

gcacagagtt caccctgacc atcagctccc tgcagccaga tgactttgcc acctactact     1800

gccagcagta caatacctac tggacctttg gccagggaac aaaggtggaa atcaagggcg     1860

gaggaggcgg aggtggagga ggagaaccca agagctgtga caagacccac acctgtcctc     1920

catgtcctgc tccagaactg cttggaggcc cttctgtgtt cctgtttcct ccaaagccta     1980

aggacaccct gatgatcagc agaacccctg aagtgacctg tgtggtggtt gatgtgtccc     2040

atgaggaccc agaagtgaag ttcaattggt atgtggatgg ggttgaagtg cacaatgcca     2100

agaccaagcc tagagaggaa cagtacaaca gcacctacag agtggtttct gtgctgacag     2160

tgctgcacca ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc     2220

tgcctgctcc tattgagaaa accatctcca aggccaaggg ccagccaaga gaaccccagg     2280

tttacaccct gccacctagc agagaagaga tgaccaagaa ccaggtgtcc ctgacctgcc     2340

tggttaaggg cttctacccc tctgacattg ctgtggaatg ggagagcaat ggccagcctg     2400

aaaacaacta caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtaca     2460

gcaagctgac tgtggacaag tccagatggc agcagggaaa tgtgttcagc tgctctgtga     2520

tgcatgaggc cctgcacaac cactacaccc agaaaagtct gtctctgtcc cctggctaat     2580

gactcgagga cggggtgaac tacgcctgag gatccgatct ttttccctct gccaaaaatt     2640

atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg aaatttattt     2700

tcattgcaat agtgtgttgg aattttttgt gtctctcact cggcggccgc ccgagtttaa     2760

ttggtttata gaactcttca agctagcgaa gcaattcgtt gatctgaatt tcgaccaccc     2820

ataataccca ttaccctggt agataagtag catggcgggt taatcattaa ctacaaggaa     2880

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     2940

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     3000

cgcag                                                                 3005


<210>  309
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; ApoE.hAAT promoter

<400>  309
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210>  310
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; chimeric intron

<400>  310
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  311
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; mIL2 leader

<400>  311
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gag                                                                     63


<210>  312
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; mIL2 leader

<400>  312

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu 
            20      


<210>  313
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab VH (codon-optimized and 
       CpG-deleted)

<400>  313
gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      180

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      300

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      360

tcctct                                                                 366


<210>  314
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab VH (codon-optimized and 
       CpG-deleted)

<400>  314

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Ser Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Arg Arg Ile Gly Val Pro Arg Arg Asp Glu Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  315
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  315
ggtggaggcg gttcaggcgg aggtggcagc ggcggtggag ggtcg                       45


<210>  316
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  316

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  317
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab VL (codon-optimized and 
       CpG-deleted)

<400>  317
gacatccaga tgacacagag cccctccaca ctgtctgcat ctgtgggaga cagagtgacc       60

atcacctgta gagccagcca gtctatctct agctggctgg cctggtatca gcaaaagcct      120

ggcaaggccc ctaagctgct gatctacaag gccagcacac ttgagtcagg ggtgccctcc      180

agattttctg gctctggatc tggcacagag ttcaccctga ccatcagctc cctgcagcca      240

gatgactttg ccacctacta ctgccagcag tacaatacct actggacctt tggccaggga      300

acaaaggtgg aaatcaag                                                    318


<210>  318
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab VL (codon-optimized and 
       CpG-deleted)

<400>  318

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  319
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  319
ggcggaggag gcggaggtgg aggagga                                           27


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; linker

<400>  320

Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   


<210>  321
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab Fc (codon-optimized and 
       CpG-deleted)

<400>  321
gaacccaaga gctgtgacaa gacccacacc tgtcctccat gtcctgctcc agaactgctt       60

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga      120

acccctgaag tgacctgtgt ggtggttgat gtgtcccatg aggacccaga agtgaagttc      180

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag      240

tacaacagca cctacagagt ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat      300

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc      360

atctccaagg ccaagggcca gccaagagaa ccccaggttt acaccctgcc acctagcaga      420

gaagagatga ccaagaacca ggtgtccctg acctgcctgg ttaagggctt ctacccctct      480

gacattgctg tggaatggga gagcaatggc cagcctgaaa acaactacaa gacaacccct      540

cctgtgctgg actctgatgg ctcattcttc ctgtacagca agctgactgt ggacaagtcc      600

agatggcagc agggaaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac      660

tacacccaga aaagtctgtc tctgtcccct ggc                                   693


<210>  322
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab Fc (codon-optimized and 
       CpG-deleted)

<400>  322

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  323
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; VH-VL-Fc sequence (including leader and 
       linkers)

<400>  323
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggaggtcc agctgcttga gagtggtggt ggactggttc agcctggtgg cagcctgaga      120

ctgtcttgtg ctgcctctgg cttcaccttc agccactata tcatgatgtg ggtcagacag      180

gcccctggca aaggcctgga atgggtgtca ggcatctaca gcagtggtgg catcacagtg      240

tatgctgact ctgtgaaggg cagattcacc atcagcagag acaacagcaa gaacaccctg      300

tacctgcaga tgaactccct gagagctgag gacacagcag tgtactactg tgcctataga      360

agaattgggg tgcccagaag ggatgagttt gacatctggg gccagggcac catggttaca      420

gtgtcctctg gtggaggcgg ttcaggcgga ggtggcagcg gcggtggagg gtcggacatc      480

cagatgacac agagcccctc cacactgtct gcatctgtgg gagacagagt gaccatcacc      540

tgtagagcca gccagtctat ctctagctgg ctggcctggt atcagcaaaa gcctggcaag      600

gcccctaagc tgctgatcta caaggccagc acacttgagt caggggtgcc ctccagattt      660

tctggctctg gatctggcac agagttcacc ctgaccatca gctccctgca gccagatgac      720

tttgccacct actactgcca gcagtacaat acctactgga cctttggcca gggaacaaag      780

gtggaaatca agggcggagg aggcggaggt ggaggaggag aacccaagag ctgtgacaag      840

acccacacct gtcctccatg tcctgctcca gaactgcttg gaggcccttc tgtgttcctg      900

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgtgtg      960

gtggttgatg tgtcccatga ggacccagaa gtgaagttca attggtatgt ggatggggtt     1020

gaagtgcaca atgccaagac caagcctaga gaggaacagt acaacagcac ctacagagtg     1080

gtttctgtgc tgacagtgct gcaccaggac tggctgaatg gcaaagagta caagtgcaag     1140

gtgtccaaca aggccctgcc tgctcctatt gagaaaacca tctccaaggc caagggccag     1200

ccaagagaac cccaggttta caccctgcca cctagcagag aagagatgac caagaaccag     1260

gtgtccctga cctgcctggt taagggcttc tacccctctg acattgctgt ggaatgggag     1320

agcaatggcc agcctgaaaa caactacaag acaacccctc ctgtgctgga ctctgatggc     1380

tcattcttcc tgtacagcaa gctgactgtg gacaagtcca gatggcagca gggaaatgtg     1440

ttcagctgct ctgtgatgca tgaggccctg cacaaccact acacccagaa aagtctgtct     1500

ctgtcccctg gc                                                         1512


<210>  324
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; VH-VL-Fc sequence (including leader and 
       linkers)

<400>  324

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser His Tyr Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Gly Ile Tyr Ser Ser Gly Gly Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Tyr Arg Arg Ile Gly Val Pro Arg Arg Asp 
        115                 120                 125             


Glu Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 
        195                 200                 205             


Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Gly Gly Gly Gly 
            260                 265                 270         


Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 


<210>  325
<211>  3862
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; 5'ITR-LMTP6 promoter- chimeric intron - 
       leader- VH- 4GSx3 linker- VL- 9G linker- Fc- polyA-3'ITR

<400>  325
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag      540

gaggcaaggc ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc      600

cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact      660

acgggtttag gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta      720

taattaaccc agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata      780

accctgtccc tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct      840

ggggacaccc gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc      900

caacacctgc tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc      960

ttcgaacaag gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta     1020

tacgtgcctg ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc     1080

ccccgccagc tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc     1140

agcccataca aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt     1200

gcccgggcaa cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc     1260

tcctggctag tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct     1320

cattctacca ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc     1380

ttgctaccag tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg     1440

gtactctccc agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg     1500

tggtttctga gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc     1560

ccaggcaaag cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc     1620

ccctgtttgc tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc     1680

cgttgcccct ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc     1740

ttcaggcacc accactgacc tgggacagtc aggtaagtat caaggttaca agacaggttt     1800

aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt ttctgatagg     1860

cacctattgg tcttactgac atccactttg cctttctctc cacaggttcg aattcgccac     1920

catgtacaga atgcagctgc tgctgctcat tgccctgtct ctggccctgg tcaccaattc     1980

tgaggaggtc cagctgcttg agagtggtgg tggactggtt cagcctggtg gcagcctgag     2040

actgtcttgt gctgcctctg gcttcacctt cagccactat atcatgatgt gggtcagaca     2100

ggcccctggc aaaggcctgg aatgggtgtc aggcatctac agcagtggtg gcatcacagt     2160

gtatgctgac tctgtgaagg gcagattcac catcagcaga gacaacagca agaacaccct     2220

gtacctgcag atgaactccc tgagagctga ggacacagca gtgtactact gtgcctatag     2280

aagaattggg gtgcccagaa gggatgagtt tgacatctgg ggccagggca ccatggttac     2340

agtgtcctct ggtggaggcg gttcaggcgg aggtggcagc ggcggtggag ggtcggacat     2400

ccagatgaca cagagcccct ccacactgtc tgcatctgtg ggagacagag tgaccatcac     2460

ctgtagagcc agccagtcta tctctagctg gctggcctgg tatcagcaaa agcctggcaa     2520

ggcccctaag ctgctgatct acaaggccag cacacttgag tcaggggtgc cctccagatt     2580

ttctggctct ggatctggca cagagttcac cctgaccatc agctccctgc agccagatga     2640

ctttgccacc tactactgcc agcagtacaa tacctactgg acctttggcc agggaacaaa     2700

ggtggaaatc aagggcggag gaggcggagg tggaggagga gaacccaaga gctgtgacaa     2760

gacccacacc tgtcctccat gtcctgctcc agaactgctt ggaggccctt ctgtgttcct     2820

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgtgt     2880

ggtggttgat gtgtcccatg aggacccaga agtgaagttc aattggtatg tggatggggt     2940

tgaagtgcac aatgccaaga ccaagcctag agaggaacag tacaacagca cctacagagt     3000

ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat ggcaaagagt acaagtgcaa     3060

ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc atctccaagg ccaagggcca     3120

gccaagagaa ccccaggttt acaccctgcc acctagcaga gaagagatga ccaagaacca     3180

ggtgtccctg acctgcctgg ttaagggctt ctacccctct gacattgctg tggaatggga     3240

gagcaatggc cagcctgaaa acaactacaa gacaacccct cctgtgctgg actctgatgg     3300

ctcattcttc ctgtacagca agctgactgt ggacaagtcc agatggcagc agggaaatgt     3360

gttcagctgc tctgtgatgc atgaggccct gcacaaccac tacacccaga aaagtctgtc     3420

tctgtcccct ggctaatgac tcgaggacgg ggtgaactac gcctgaggat ccgatctttt     3480

tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta     3540

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg     3600

cggccgcccg agtttaattg gtttatagaa ctcttcaagc tagcgaagca attcgttgat     3660

ctgaatttcg accacccata atacccatta ccctggtaga taagtagcat ggcgggttaa     3720

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3780

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3840

cagtgagcga gcgagcgcgc ag                                              3862


<210>  326
<211>  1579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; LMTP6 promoter

<400>  326
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagt                                                  1579


<210>  327
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; chimeric intron

<400>  327
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  328
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; mIL2 leader

<400>  328
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gag                                                                     63


<210>  329
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct;

<400>  329

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu 
            20      


<210>  330
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab VH (codon-optimized and 
       CpG-deleted)

<400>  330
gaggtccagc tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc      120

cctggcaaag gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat      180

gctgactctg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga      300

attggggtgc ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg      360

tcctct                                                                 366


<210>  331
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; Lanadelumab VH (codon-optimized and 
       CpG-deleted)

<400>  331

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Ser Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Arg Arg Ile Gly Val Pro Arg Arg Asp Glu Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  332
<211>  3005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; 5'ITR-ApoE.hAAT promoter- chimeric intron - 
       leader- VL- 4GSx3 linker- VH- 9G linker- Fc- polyA-3'ITR

<400>  332
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac      540

agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac      600

tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg      660

tacaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg      720

ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc      780

gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat      840

ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact      900

gacctgggac agtcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa      960

actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac     1020

tgacatccac tttgcctttc tctccacagg ttgaattcgc caccatgtac agaatgcagc     1080

tgctgctgct cattgccctg tctctggccc tggtcaccaa ttctgaggac atccagatga     1140

cacagagccc ctccacactg tctgcatctg tgggagacag agtgaccatc acctgtagag     1200

ccagccagtc tatctctagc tggctggcct ggtatcagca aaagcctggc aaggccccta     1260

agctgctgat ctacaaggcc agcacacttg agtcaggggt gccctccaga ttttctggct     1320

ctggatctgg cacagagttc accctgacca tcagctccct gcagccagat gactttgcca     1380

cctactactg ccagcagtac aatacctact ggacctttgg ccagggaaca aaggtggaaa     1440

tcaagggtgg aggcggttca ggcggaggtg gcagcggcgg tggagggtcg gaggtccagc     1500

tgcttgagag tggtggtgga ctggttcagc ctggtggcag cctgagactg tcttgtgctg     1560

cctctggctt caccttcagc cactatatca tgatgtgggt cagacaggcc cctggcaaag     1620

gcctggaatg ggtgtcaggc atctacagca gtggtggcat cacagtgtat gctgactctg     1680

tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac ctgcagatga     1740

actccctgag agctgaggac acagcagtgt actactgtgc ctatagaaga attggggtgc     1800

ccagaaggga tgagtttgac atctggggcc agggcaccat ggttacagtg tcctctggcg     1860

gaggaggcgg aggtggagga ggagaaccca agagctgtga caagacccac acctgtcctc     1920

catgtcctgc tccagaactg cttggaggcc cttctgtgtt cctgtttcct ccaaagccta     1980

aggacaccct gatgatcagc agaacccctg aagtgacctg tgtggtggtt gatgtgtccc     2040

atgaggaccc agaagtgaag ttcaattggt atgtggatgg ggttgaagtg cacaatgcca     2100

agaccaagcc tagagaggaa cagtacaaca gcacctacag agtggtttct gtgctgacag     2160

tgctgcacca ggactggctg aatggcaaag agtacaagtg caaggtgtcc aacaaggccc     2220

tgcctgctcc tattgagaaa accatctcca aggccaaggg ccagccaaga gaaccccagg     2280

tttacaccct gccacctagc agagaagaga tgaccaagaa ccaggtgtcc ctgacctgcc     2340

tggttaaggg cttctacccc tctgacattg ctgtggaatg ggagagcaat ggccagcctg     2400

aaaacaacta caagacaacc cctcctgtgc tggactctga tggctcattc ttcctgtaca     2460

gcaagctgac tgtggacaag tccagatggc agcagggaaa tgtgttcagc tgctctgtga     2520

tgcatgaggc cctgcacaac cactacaccc agaaaagtct gtctctgtcc cctggctaat     2580

gactcgagga cggggtgaac tacgcctgag gatccgatct ttttccctct gccaaaaatt     2640

atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg aaatttattt     2700

tcattgcaat agtgtgttgg aattttttgt gtctctcact cggcggccgc ccgagtttaa     2760

ttggtttata gaactcttca agctagcgaa gcaattcgtt gatctgaatt tcgaccaccc     2820

ataataccca ttaccctggt agataagtag catggcgggt taatcattaa ctacaaggaa     2880

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     2940

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     3000

cgcag                                                                 3005


<210>  333
<211>  3862
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; 5'ITR-LMTP6 promoter- chimeric intron - 
       leader- VL- 4GSx3 linker- VH- 9G linker- Fc- polyA-3'ITR

<400>  333
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag      540

gaggcaaggc ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc      600

cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact      660

acgggtttag gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta      720

taattaaccc agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata      780

accctgtccc tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct      840

ggggacaccc gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc      900

caacacctgc tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc      960

ttcgaacaag gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta     1020

tacgtgcctg ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc     1080

ccccgccagc tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc     1140

agcccataca aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt     1200

gcccgggcaa cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc     1260

tcctggctag tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct     1320

cattctacca ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc     1380

ttgctaccag tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg     1440

gtactctccc agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg     1500

tggtttctga gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc     1560

ccaggcaaag cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc     1620

ccctgtttgc tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc     1680

cgttgcccct ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc     1740

ttcaggcacc accactgacc tgggacagtc aggtaagtat caaggttaca agacaggttt     1800

aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt ttctgatagg     1860

cacctattgg tcttactgac atccactttg cctttctctc cacaggttcg aattcgccac     1920

catgtacaga atgcagctgc tgctgctcat tgccctgtct ctggccctgg tcaccaattc     1980

tgaggacatc cagatgacac agagcccctc cacactgtct gcatctgtgg gagacagagt     2040

gaccatcacc tgtagagcca gccagtctat ctctagctgg ctggcctggt atcagcaaaa     2100

gcctggcaag gcccctaagc tgctgatcta caaggccagc acacttgagt caggggtgcc     2160

ctccagattt tctggctctg gatctggcac agagttcacc ctgaccatca gctccctgca     2220

gccagatgac tttgccacct actactgcca gcagtacaat acctactgga cctttggcca     2280

gggaacaaag gtggaaatca agggtggagg cggttcaggc ggaggtggca gcggcggtgg     2340

agggtcggag gtccagctgc ttgagagtgg tggtggactg gttcagcctg gtggcagcct     2400

gagactgtct tgtgctgcct ctggcttcac cttcagccac tatatcatga tgtgggtcag     2460

acaggcccct ggcaaaggcc tggaatgggt gtcaggcatc tacagcagtg gtggcatcac     2520

agtgtatgct gactctgtga agggcagatt caccatcagc agagacaaca gcaagaacac     2580

cctgtacctg cagatgaact ccctgagagc tgaggacaca gcagtgtact actgtgccta     2640

tagaagaatt ggggtgccca gaagggatga gtttgacatc tggggccagg gcaccatggt     2700

tacagtgtcc tctggcggag gaggcggagg tggaggagga gaacccaaga gctgtgacaa     2760

gacccacacc tgtcctccat gtcctgctcc agaactgctt ggaggccctt ctgtgttcct     2820

gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgtgt     2880

ggtggttgat gtgtcccatg aggacccaga agtgaagttc aattggtatg tggatggggt     2940

tgaagtgcac aatgccaaga ccaagcctag agaggaacag tacaacagca cctacagagt     3000

ggtttctgtg ctgacagtgc tgcaccagga ctggctgaat ggcaaagagt acaagtgcaa     3060

ggtgtccaac aaggccctgc ctgctcctat tgagaaaacc atctccaagg ccaagggcca     3120

gccaagagaa ccccaggttt acaccctgcc acctagcaga gaagagatga ccaagaacca     3180

ggtgtccctg acctgcctgg ttaagggctt ctacccctct gacattgctg tggaatggga     3240

gagcaatggc cagcctgaaa acaactacaa gacaacccct cctgtgctgg actctgatgg     3300

ctcattcttc ctgtacagca agctgactgt ggacaagtcc agatggcagc agggaaatgt     3360

gttcagctgc tctgtgatgc atgaggccct gcacaaccac tacacccaga aaagtctgtc     3420

tctgtcccct ggctaatgac tcgaggacgg ggtgaactac gcctgaggat ccgatctttt     3480

tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta     3540

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg     3600

cggccgcccg agtttaattg gtttatagaa ctcttcaagc tagcgaagca attcgttgat     3660

ctgaatttcg accacccata atacccatta ccctggtaga taagtagcat ggcgggttaa     3720

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3780

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3840

cagtgagcga gcgagcgcgc ag                                              3862


<210>  334
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; AAV2 capsid

<400>  334

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  335
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; transcription start site

<400>  335
tctcc                                                                    5


<210>  336
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  336
ggtacagtga ctcctttcg                                                    19


<210>  337
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; promoter sequence

<400>  337
ggtacaatga ctcctttcg                                                    19


<210>  338
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct; transcription start site

<400>  338
tcattctacc                                                              10


<210>  339
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  339

Ser Thr Val Asp His Pro 
1               5       


<210>  340
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  340

Glu Thr Val Gly 
1               


<210>  341
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  341

Gln Phe Leu Lys 
1               


<210>  342
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  342

Pro Ala Glu Arg Lys Lys 
1               5       


<210>  343
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  343

Gln Gly Gly Glu 
1               


<210>  344
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  344

Gly Ile Asp Asp His Phe 
1               5       


<210>  345
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  345

Lys Lys Gln Ala Arg Thr Arg Glu Lys Ser Val Pro Glu Asp Glu Thr 
1               5                   10                  15      


Gly Ala 
        


<210>  346
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  346

Ala Leu Ile Pro 
1               


<210>  347
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  347

Ser Thr Ser Ser 
1               


<210>  348
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  348

Gln Leu Gln Gln Thr Ser Gly Thr Met Ala Ser Leu Asp Pro Asn Glu 
1               5                   10                  15      


Val Arg Ala Ala Ala 
            20      


<210>  349
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  349

Gly Ala Met Gly Glu Gly Gly Gln 
1               5               


<210>  350
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  350

Met Glu Gly His 
1               


<210>  351
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  351

Ala Gln Pro Ala Thr Ala 
1               5       


<210>  352
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  352

Arg Arg Leu Gly Ser Gly Ser Gln Ser Asp Ala Thr Gln Ala 
1               5                   10                  


<210>  353
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  353

Ala Ala Thr Thr Glu Gly Leu 
1               5           


<210>  354
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  354

Arg Ala Met Arg Val 
1               5   


<210>  355
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  355

Val Gln Asp Ser Thr Thr 
1               5       


<210>  356
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  356

Gly Asn Pro Thr Asp 
1               5   


<210>  357
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  357

Trp Gly Phe Asn Arg 
1               5   


<210>  358
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  358

Gln Thr Asn Thr Ser 
1               5   


<210>  359
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  359

Ala Gly Thr Lys Arg Thr Gln 
1               5           


<210>  360
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  360

Thr Gln Gly Ser Ala Ala Thr Phe Ser Asn 
1               5                   10  


<210>  361
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  361

Asn Ser Thr Pro Thr 
1               5   


<210>  362
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  362

Thr Gln Asn Ser Asp Val Asn 
1               5           


<210>  363
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  363

Asn Lys Asn Leu 
1               


<210>  364
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  364

Gln Gly Tyr Arg Asp 
1               5   


<210>  365
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  365

Tyr Arg Leu Arg 
1               


<210>  366
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  366

Cys Ile Lys Thr 
1               


<210>  367
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  367

Gly Trp Asn Leu Gly Ser Gly Val 
1               5               


<210>  368
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  368

Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr 
1               5                   10      


<210>  369
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  369

Ala Ser Tyr Gln Val Pro 
1               5       


<210>  370
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  370

Gln Thr Pro Gly Met Thr Ala Gly 
1               5               


<210>  371
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  371

Asn Tyr Thr Phe Ala Thr Thr Asn Arg Met Glu 
1               5                   10      


<210>  372
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  372

Leu Gln Gly Ser Asn Thr Tyr Ala Met Glu Asn Thr Met Phe Ala Asn 
1               5                   10                  15      


Pro Lys Gln Asn 
            20  


<210>  373
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  373

Thr Asn Thr Ala Thr Val Pro Gly 
1               5               


<210>  374
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  374

Thr Leu Ile Phe 
1               


<210>  375
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  375

Thr Gln Pro Val 
1               


<210>  376
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  376

Ala Thr Asp Tyr Asp Met Trp 
1               5           


<210>  377
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  377

Asn Leu Pro Gly Gly Asp 
1               5       


<210>  378
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  378

Pro Ala Asp Glu Lys 
1               5   


<210>  379
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  379

Gln His Gln Leu Ile 
1               5   


<210>  380
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  380

Ser Glu Ser Ala 
1               


<210>  381
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  381

Glu Ala Ser Lys Ala Ala Leu Glu 
1               5               


<210>  382
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  382

Asn Met Leu Met 
1               


<210>  383
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  383

Thr Met Ser Asn 
1               


<210>  384
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  384

Arg Asn Ser Asn Leu Pro Thr Val Asp Arg Leu Thr Ala Leu Glu Ala 
1               5                   10                  15      


Val 
    


<210>  385
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  385

Ala Ser Asn Thr Ala 
1               5   


<210>  386
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  386

Ala Ile Ala Asp Tyr His Thr Met 
1               5               


<210>  387
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  387

Asn Asp Pro Gln Phe 
1               5   


<210>  388
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  388

Gln Gly Thr Arg Asp 
1               5   


<210>  389
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  389

Ile Ala Ala Glu 
1               


<210>  390
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  390

Ser Asp Val Pro Val Ser 
1               5       


<210>  391
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutations in AAV capsids

<400>  391

Gly Gln Gln Val Ser Leu Leu Trp Thr Pro Asp Ala Ala 
1               5                   10              


<210>  392
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; VL-VH-Fc sequence

<400>  392
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaggacatcc agatgacaca gagcccctcc acactgtctg catctgtggg agacagagtg      120

accatcacct gtagagccag ccagtctatc tctagctggc tggcctggta tcagcaaaag      180

cctggcaagg cccctaagct gctgatctac aaggccagca cacttgagtc aggggtgccc      240

tccagatttt ctggctctgg atctggcaca gagttcaccc tgaccatcag ctccctgcag      300

ccagatgact ttgccaccta ctactgccag cagtacaata cctactggac ctttggccag      360

ggaacaaagg tggaaatcaa gggtggaggc ggttcaggcg gaggtggcag cggcggtgga      420

gggtcggagg tccagctgct tgagagtggt ggtggactgg ttcagcctgg tggcagcctg      480

agactgtctt gtgctgcctc tggcttcacc ttcagccact atatcatgat gtgggtcaga      540

caggcccctg gcaaaggcct ggaatgggtg tcaggcatct acagcagtgg tggcatcaca      600

gtgtatgctg actctgtgaa gggcagattc accatcagca gagacaacag caagaacacc      660

ctgtacctgc agatgaactc cctgagagct gaggacacag cagtgtacta ctgtgcctat      720

agaagaattg gggtgcccag aagggatgag tttgacatct ggggccaggg caccatggtt      780

acagtgtcct ctggcggagg aggcggaggt ggaggaggag aacccaagag ctgtgacaag      840

acccacacct gtcctccatg tcctgctcca gaactgcttg gaggcccttc tgtgttcctg      900

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgtgtg      960

gtggttgatg tgtcccatga ggacccagaa gtgaagttca attggtatgt ggatggggtt     1020

gaagtgcaca atgccaagac caagcctaga gaggaacagt acaacagcac ctacagagtg     1080

gtttctgtgc tgacagtgct gcaccaggac tggctgaatg gcaaagagta caagtgcaag     1140

gtgtccaaca aggccctgcc tgctcctatt gagaaaacca tctccaaggc caagggccag     1200

ccaagagaac cccaggttta caccctgcca cctagcagag aagagatgac caagaaccag     1260

gtgtccctga cctgcctggt taagggcttc tacccctctg acattgctgt ggaatgggag     1320

agcaatggcc agcctgaaaa caactacaag acaacccctc ctgtgctgga ctctgatggc     1380

tcattcttcc tgtacagcaa gctgactgtg gacaagtcca gatggcagca gggaaatgtg     1440

ttcagctgct ctgtgatgca tgaggccctg cacaaccact acacccagaa aagtctgtct     1500

ctgtcccctg gc                                                         1512


<210>  393
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; VH-VL-Fc sequence

<400>  393

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Thr Tyr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Ile Met 
                165                 170                 175     


Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
            180                 185                 190         


Ile Tyr Ser Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Tyr 
225                 230                 235                 240 


Arg Arg Ile Gly Val Pro Arg Arg Asp Glu Phe Asp Ile Trp Gly Gln 
                245                 250                 255     


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly 
            260                 265                 270         


Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 


