                         SEQUENCE LISTING

<110>  Planet Biotechnology, Inc.
       WYCOFF, Keith L
       TRAN, Y
 
<120>  FACTOR H FRAGMENT Fc FUSIONS WITH IMPROVED POTENCY AND 
       MANUFACTURABILITY

<130>  16188-002WO1

<150>  63/204194
<151>  2020-09-16

<150>  63/258022
<151>  2021-04-05

<150>  63/259003
<151>  2021-06-11

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  2
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Phe Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  5
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  6
<211>  575
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  6
ctgcaggtgt tcactcctgc gtcaaccccc ccaccgtgca gaacgcctac atcgtgtccc       60

ggcagatgag caagtacccc tccggtgaga gggtgagata ccagtgccgt tccccctacg      120

agatgttcgg ggacgaggag gtgatgtgcc tcaacggtaa ctggaccgag cccccccagt      180

gcaaggactc caccggtaag tgtggacccc ccccccccat cgacaacggc gggatcacct      240

ccttcccgct gtccgtctac gccccggcct cctccgtcga gtatcagtgc cagaacctgt      300

accagctcga gggcaacaag aggatcacct gccgtaacgg tcagtggtcc gagcccccca      360

agtgcctcca tccctgcgtg atcagccgtg agatcatgga gaactacaac atcgccctgc      420

ggtggaccgc caagcagaag ctctactcca ggaccggcga gagcgtcgag tttgtgtgca      480

agcgtggtta ccggctctcc tccaggtccc ataccctcag gaccacctgc tgggacggca      540

agctcgagta ccccacctgt gccaagaggg agctc                                 575


<210>  7
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  7
atggagtgga gctggatctt cttgttcttg ctcagcggca ctgcaggtgt tcactcctgc       60

gtcaaccccc ccaccgtgca gaacgcctac atcgtgtccc ggcagatgag caagtacccc      120

tccggtgaga gggtgagata ccagtgccgt tccccctacg agatgttcgg ggacgaggag      180

gtgatgtgcc tcaacggtaa ctggaccgag cccccccagt gcaaggactc caccggtaag      240

tgtggacccc ccccccccat cgacaacggc gggatcacct ccttcccgct gtccgtctac      300

gccccggcct cctccgtcga gtatcagtgc cagaacctgt accagctcga gggcaacaag      360

aggatcacct gccgtaacgg tcagtggtcc gagcccccca agtgcctcca tccctgcgtg      420

atcagccgtg agatcatgga gaactacaac atcgccctgc ggtggaccgc caagcagaag      480

ctctactcca ggaccggcga gagcgtcgag tttgtgtgca agcgtggtta ccggctctcc      540

tccaggtccc ataccctcag gaccacctgc tgggacggca agctcgagta ccccacctgt      600

gccaagaggg ccgctgccgg tgggagctct gagcctaagt catgcgataa gactcatact      660

tgtcctcctt gtccggcgcc tgaacttctt ggaggacctt ctgttttcct ttttcctcct      720

aagccaaagg acactcttat gattagtagg actcctgaag ttacttgcgt tgttgttgat      780

gtttctcacg aagatcctga agtgaagttt aactggtatg ttgatggagt tgaggtgcac      840

aatgctaaga ctaagcctcg tgaggaacaa tataattcta cttacagggt agtgtctgtg      900

ttgacagtgc ttcatcaaga ttggcttaac gggaaagaat ataagtgcaa ggtttctaat      960

aaggctctcc cggcgcccat tgaaaagacc atttctaagg ctaagggaca acctagagaa     1020

cctcaagttt acactcttcc tccttctcgt gatgagttaa ccaagaacca ggtttctctt     1080

acttgtttgg tgaagggatt ctacccaagt gacattgctg tggagtggga atctaatgga     1140

cagcctgaga acaactataa gactactcct cctgttcttg attctgacgg atcattcttc     1200

ttatacagca agttgaccgt tgataagtcc agatggcaac aaggaaatgt tttcagttgc     1260

tctgttatgc atgaagcatt acataaccac tacactcaaa agtctctttc tctttcgccg     1320

gggaaataa                                                             1329


<210>  8
<211>  442
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  8

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
            20                  25                  30          


Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
        35                  40                  45              


Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
    50                  55                  60                  


Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
65                  70                  75                  80  


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Gly Ile Thr Ser Phe Pro 
                85                  90                  95      


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
            100                 105                 110         


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
        115                 120                 125             


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
    130                 135                 140                 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
145                 150                 155                 160 


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
                165                 170                 175     


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
            180                 185                 190         


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Ala Ala Ala Gly Gly 
        195                 200                 205             


Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  9
<211>  1341
<212>  DNA
<213>  artificial

<220>
<223>  Synthetic polynucleotide

<400>  9
atggagtgga gctggatctt cttgttcttg ctcagcggca ctgcaggtgt tcactcctgc       60

gtcaaccccc ccaccgtgca gaacgcctac atcgtgtccc ggcagatgag caagtacccc      120

tccggtgaga gggtgagata ccagtgccgt tccccctacg agatgttcgg ggacgaggag      180

gtgatgtgcc tcaacggtaa ctggaccgag cccccccagt gcaaggactc caccggtaag      240

tgtggacccc ccccccccat cgacaacggc gggatcacct ccttcccgct gtccgtctac      300

gccccggcct cctccgtcga gtatcagtgc cagaacctgt accagctcga gggcaacaag      360

aggatcacct gccgtaacgg tcagtggtcc gagcccccca agtgcctcca tccctgcgtg      420

atcagccgtg agatcatgga gaactacaac atcgccctgc ggtggaccgc caagcagaag      480

ctctactcca ggaccggcga gagcgtcgag tttgtgtgca agcgtggtta ccggctctcc      540

tccaggtccc ataccctcag gaccacctgc tgggacggca agctcgagta ccccacctgt      600

gccaagaggg gcggcggtgg ttctggtggt ggcgggagct ctgagcctaa gtcatgcgat      660

aagactcata cttgtcctcc ttgtccggcg cctgaacttc ttggaggacc ttctgttttc      720

ctttttcctc ctaagccaaa ggacactctt atgattagta ggactcctga agttacttgc      780

gttgttgttg atgtttctca cgaagatcct gaagtgaagt ttaactggta tgttgatgga      840

gttgaggtgc acaatgctaa gactaagcct cgtgaggaac aatataattc tacttacagg      900

gtagtgtctg tgttgacagt gcttcatcaa gattggctta acgggaaaga atataagtgc      960

aaggtttcta ataaggctct cccggcgccc attgaaaaga ccatttctaa ggctaaggga     1020

caacctagag aacctcaagt ttacactctt cctccttctc gtgatgagtt aaccaagaac     1080

caggtttctc ttacttgttt ggtgaaggga ttctacccaa gtgacattgc tgtggagtgg     1140

gaatctaatg gacagcctga gaacaactat aagactactc ctcctgttct tgattctgac     1200

ggatcattct tcttatacag caagttgacc gttgataagt ccagatggca acaaggaaat     1260

gttttcagtt gctctgttat gcatgaagca ttacataacc actacactca aaagtctctt     1320

tctctttcgc cggggaaata a                                               1341


<210>  10
<211>  446
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic polypeptide

<400>  10

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
            20                  25                  30          


Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
        35                  40                  45              


Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
    50                  55                  60                  


Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
65                  70                  75                  80  


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Gly Ile Thr Ser Phe Pro 
                85                  90                  95      


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
            100                 105                 110         


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
        115                 120                 125             


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
    130                 135                 140                 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
145                 150                 155                 160 


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
                165                 170                 175     


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
            180                 185                 190         


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  11
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  11
atggagtgga gctggatctt cttgttcttg ctcagcggca ctgcaggtgt tcactcctgc       60

gtcaaccccc ccaccgtgca gaacgcctac atcgtgtccc ggcagatgag caagtacccc      120

tccggtgaga gggtgagata ccagtgccgt tccccctacg agatgttcgg ggacgaggag      180

gtgatgtgcc tcaacggtaa ctggaccgag cccccccagt gcaaggactc caccggtaag      240

tgtggacccc ccccccccat cgacaacggc gggatcacct ccttcccgct gtccgtctac      300

gccccggcct cctccgtcga gtatcagtgc cagaacctgt accagctcga gggcaacaag      360

aggatcacct gccgtaacgg tcagtggtcc gagcccccca agtgcctcca tccctgcgtg      420

atcagccgtg agatcatgga gaactacaac atcgccctgc ggtggaccgc caagcagaag      480

ctctactcca ggaccggcga gagcgtcgag tttgtgtgca agcgtggtta ccggctctcc      540

tccaggtccc ataccctcag gaccacctgc tgggacggca agctcgagta ccccacctgt      600

gccaagaggg gcggcggtgg ttctgggggt ggcgggtctg gcggcggggg gagctctgag      660

cctaagtcat gcgataagac tcatacttgt cctccttgtc cggcgcctga acttcttgga      720

ggaccttctg ttttcctttt tcctcctaag ccaaaggaca ctcttatgat tagtaggact      780

cctgaagtta cttgcgttgt tgttgatgtt tctcacgaag atcctgaagt gaagtttaac      840

tggtatgttg atggagttga ggtgcacaat gctaagacta agcctcgtga ggaacaatat      900

aattctactt acagggtagt gtctgtgttg acagtgcttc atcaagattg gcttaacggg      960

aaagaatata agtgcaaggt ttctaataag gctctcccgg cgcccattga aaagaccatt     1020

tctaaggcta agggacaacc tagagaacct caagtttaca ctcttcctcc ttctcgtgat     1080

gagttaacca agaaccaggt ttctcttact tgtttggtga agggattcta cccaagtgac     1140

attgctgtgg agtgggaatc taatggacag cctgagaaca actataagac tactcctcct     1200

gttcttgatt ctgacggatc attcttctta tacagcaagt tgaccgttga taagtccaga     1260

tggcaacaag gaaatgtttt cagttgctct gttatgcatg aagcattaca taaccactac     1320

actcaaaagt ctctttctct ttcgccgggg aaataa                               1356


<210>  12
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  12

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
            20                  25                  30          


Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
        35                  40                  45              


Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
    50                  55                  60                  


Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
65                  70                  75                  80  


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Gly Ile Thr Ser Phe Pro 
                85                  90                  95      


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
            100                 105                 110         


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
        115                 120                 125             


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
    130                 135                 140                 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
145                 150                 155                 160 


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
                165                 170                 175     


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
            180                 185                 190         


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  13
<211>  1314
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  13
atggagtgga gctggatctt cttgttcttg ctcagcggca ctgcaggtgt tcactcctgc       60

gtcaaccccc ccaccgtgca gaacgcctac atcgtgtccc ggcagatgag caagtacccc      120

tccggtgaga gggtgagata ccagtgccgt tccccctacg agatgttcgg ggacgaggag      180

gtgatgtgcc tcaacggtaa ctggaccgag cccccccagt gcaaggactc caccggtaag      240

tgtggacccc ccccccccat cgacaacggc gggatcacct ccttcccgct gtccgtctac      300

gccccggcct cctccgtcga gtatcagtgc cagaacctgt accagctcga gggcaacaag      360

aggatcacct gccgtaacgg tcagtggtcc gagcccccca agtgcctcca tccctgcgtg      420

atcagccgtg agatcatgga gaactacaac atcgccctgc ggtggaccgc caagcagaag      480

ctctactcca ggaccggcga gagcgtcgag tttgtgtgca agcgtggtta ccggctctcc      540

tccaggtccc ataccctcag gaccacctgc tgggacggca agctcgagta ccccacctgt      600

gccaagagga gctctgagcc taagtcatgc gataagactc atacttgtcc tccttgtccg      660

gcgcctgaac ttcttggagg accttctgtt ttcctttttc ctcctaagcc aaaggacact      720

cttatgatta gtaggactcc tgaagttact tgcgttgttg ttgatgtttc tcacgaagat      780

cctgaagtga agtttaactg gtatgttgat ggagttgagg tgcacaatgc taagactaag      840

cctcgtgagg aacaatataa ttctacttac agggtagtgt ctgtgttgac agtgcttcat      900

caagattggc ttaacgggaa agaatataag tgcaaggttt ctaataaggc tctcccggcg      960

cccattgaaa agaccatttc taaggctaag ggacaaccta gagaacctca agtttacact     1020

cttcctcctt ctcgtgatga gttaaccaag aaccaggttt ctcttacttg tttggtgaag     1080

ggattctacc caagtgacat tgctgtggag tgggaatcta atggacagcc tgagaacaac     1140

tataagacta ctcctcctgt tcttgattct gacggatcat tcttcttata cagcaagttg     1200

accgttgata agtccagatg gcaacaagga aatgttttca gttgctctgt tatgcatgaa     1260

gcattacata accactacac tcaaaagtct ctttctcttt cgccggggaa ataa           1314


<210>  14
<211>  437
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  14

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val 
            20                  25                  30          


Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln 
        35                  40                  45              


Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu 
    50                  55                  60                  


Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys 
65                  70                  75                  80  


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Gly Ile Thr Ser Phe Pro 
                85                  90                  95      


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
            100                 105                 110         


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
        115                 120                 125             


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
    130                 135                 140                 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
145                 150                 155                 160 


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
                165                 170                 175     


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
            180                 185                 190         


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg Ser Ser Glu Pro Lys 
        195                 200                 205             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    210                 215                 220                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
225                 230                 235                 240 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                245                 250                 255     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            260                 265                 270         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        275                 280                 285             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    290                 295                 300                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
305                 310                 315                 320 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                325                 330                 335     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            340                 345                 350         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        355                 360                 365             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    370                 375                 380                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
385                 390                 395                 400 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                405                 410                 415     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            420                 425                 430         


Leu Ser Pro Gly Lys 
        435         


<210>  15
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  15
atggagtgga gctggatctt cttgttcttg ctcagcggca ctgcaggtgt tcactccgat       60

aagactcata cttgtcctcc ttgtccggcg cctgaacttc ttggaggacc ttctgttttc      120

ctttttcctc ctaagccaaa ggacactctt atgattagta ggactcctga agttacttgc      180

gttgttgttg atgtttctca cgaagatcct gaagtgcagt ttaagtggta tgttgatgga      240

gttgaggtgc acaatgctaa gactaagcct cgtgaggaac aatataattc tactttcagg      300

gtagtgtctg tgttgacagt gcttcatcaa gattggctta acgggaaaga atataagtgc      360

aaggtttcta ataaggctct cccggcgccc attgaaaaga ccatttctaa gactaaggga      420

caacctagag aacctcaagt ttacactctt cctccttctc gtgaggagat gaccaagaac      480

caggtttctc ttacttgttt ggtgaaggga ttctacccaa gtgacattgc tgtggagtgg      540

gaatcttctg gacagcctga gaacaactat aacactactc ctcctatgct tgattctgac      600

ggatcattct tcttatacag caagttgacc gttgataagt ccagatggca acaaggaaat      660

attttcagtt gctctgttat gcatgaagca ttacataacc acttcactca aaagtctctt      720

tctctttcgc cggggaaagc ggccgcgggc ggcggtggtt ctggtggtgg cgggagcacc      780

tcctgcgtca acccccccac cgtgcagaac gcctacatcg tgtcccggca gatgagcaag      840

tacccctccg gtgagagggt gagataccag tgccgttccc cctacgagat gttcggggac      900

gaggaggtga tgtgcctcaa cggtaactgg accgagcccc cccagtgcaa ggactccacc      960

ggtaagtgtg gacccccccc ccccatcgac aacggcggga tcacctcctt cccgctgtcc     1020

gtctacgccc cggcctcctc cgtcgagtat cagtgccaga acctgtacca gctcgagggc     1080

aacaagagga tcacctgccg taacggtcag tggtccgagc cccccaagtg cctccatccc     1140

tgcgtgatca gccgtgagat catggagaac tacaacatcg ccctgcggtg gaccgccaag     1200

cagaagctct actccaggac cggcgagagc gtcgagtttg tgtgcaagcg tggttaccgg     1260

ctctcctcca ggtcccatac cctcaggacc acctgctggg acggcaagct cgagtacccc     1320

acctgtgcca agaggtaa                                                   1338


<210>  16
<211>  465
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  16

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Cys 
        35                  40                  45              


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    50                  55                  60                  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
65                  70                  75                  80  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp 
                85                  90                  95      


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            100                 105                 110         


Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu 
        115                 120                 125             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    130                 135                 140                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
145                 150                 155                 160 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                165                 170                 175     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            180                 185                 190         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn 
        195                 200                 205             


Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
    210                 215                 220                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
225                 230                 235                 240 


Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Phe Thr 
                245                 250                 255     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Thr Ser Cys Val Asn Pro Pro Thr Val 
        275                 280                 285             


Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly 
    290                 295                 300                 


Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp 
305                 310                 315                 320 


Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys 
                325                 330                 335     


Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly 
            340                 345                 350         


Gly Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val 
        355                 360                 365             


Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile 
    370                 375                 380                 


Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro 
385                 390                 395                 400 


Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
                405                 410                 415     


Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
            420                 425                 430         


Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
        435                 440                 445             


Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
    450                 455                 460                 


Arg 
465 


<210>  17
<211>  8885
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  17
aattccgccc ctagaaatat ttgcgactct tctggcatgt aatatttcgt taaatatgaa       60

gtgctccatt tttattaact ttaaataatt ggttgtacga tcactttctt atcaagcgtt      120

actaaaatgc gtcaatctct ttgttcttcc atattcatat gtcaaaatct atcaaaattc      180

ttatatatct ttttcgaatt tgaagtgaaa tttcgataat ttaaaattaa atagaacata      240

tcattattta ggtgtcatat tgatttttat acttaattac taaatttggt taactttgaa      300

agtgtacatc aacgaaaaat tagtcaaacg actaaaataa ataaatatca tgtgttatta      360

agaaaattct cctataagaa tattttaata gatcatatgt ttgtaaaaaa aattaatttt      420

tactaacaca tatatttact tatcaaaaat ttgacaaagt aagattaaaa taatattcat      480

ctaacaaaaa aaaaccagaa aatgctgaaa acccggcaaa accgaaccaa tccaaaccga      540

tatagttggt ttggtttgat tttgatataa accgaaccaa ctcggtccat ttgcacccct      600

aatcataata gctttaatat ttcaagatat tattaagtta acgttgtcaa tatcctggaa      660

attttgcaaa atgaatcaag cctatatggc tgtaatatga atttaaaagc agctcgatgt      720

ggtggtaata tgtaatttac ttgattctaa aaaaatatcc caagtattaa taatttctgc      780

taggaagaag gttagctacg atttacagca aagccagaat acaaagaacc ataaagtgat      840

tgaagctcga aatatacgaa ggaacaaata tttttaaaaa aatacgcaat gacttggaac      900

aaaagaaagt gatatatttt ttgttcttaa acaagcatcc cctctaaaga atggcagttt      960

tcctttgcat gtaactatta tgctcccttc gttacaaaaa ttttggacta ctattgggcg     1020

cggggcgcgc ccggtccaaa gaccagaggg ctattgagac ttttcaacaa agggtaatat     1080

cgggaaacct cctcggattc cattgcccag ctatctgtca cttcatcgaa aggacagtag     1140

aaaaggaaga tggcttctac aaatgccatc attgcgataa aggaaaggct atcgttcaag     1200

atgcctctac cgacagtggt cccaaagatg gacccccacc cacgaggaac atcgtggaaa     1260

aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgataca tggtggagca     1320

cgacactctc gtctactcca agaatatcaa agatacagtc tcagaagacc agagggctat     1380

tgagactttt caacaaaggg taatatcggg aaacctcctc ggattccatt gcccagctat     1440

ctgtcacttc atcgaaagga cagtagaaaa ggaagatggc ttctacaaat gccatcattg     1500

cgataaagga aaggctatcg ttcaagatgc ctctaccgac agtggtccca aagatggacc     1560

cccacccacg aggaacatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     1620

ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact atccttcgca     1680

agacccttcc tctatataag gaagttcatt tcatttggag aggacacgct gaattcacaa     1740

cacaaatcag atttatagag agatttataa aaaaaaaaaa aacaatggag tggagctgga     1800

tcttcttgtt cttgctcagc ggcactgcag gtgttcactc cgataagact catacttgtc     1860

ctccttgtcc ggcgcctgaa cttcttggag gaccttctgt tttccttttt cctcctaagc     1920

caaaggacac tcttatgatt agtaggactc ctgaagttac ttgcgttgtt gttgatgttt     1980

ctcacgaaga tcctgaagtg cagtttaagt ggtatgttga tggagttgag gtgcacaatg     2040

ctaagactaa gcctcgtgag gaacaatata attctacttt cagggtagtg tctgtgttga     2100

cagtgcttca tcaagattgg cttaacggga aagaatataa gtgcaaggtt tctaataagg     2160

ctctcccggc gcccattgaa aagaccattt ctaagactaa gggacaacct agagaacctc     2220

aagtttacac tcttcctcct tctcgtgagg agatgaccaa gaaccaggtt tctcttactt     2280

gtttggtgaa gggattctac ccaagtgaca ttgctgtgga gtgggaatct tctggacagc     2340

ctgagaacaa ctataacact actcctccta tgcttgattc tgacggatca ttcttcttat     2400

acagcaagtt gaccgttgat aagtccagat ggcaacaagg aaatattttc agttgctctg     2460

ttatgcatga agcattacat aaccacttca ctcaaaagtc tctttctctt tcgccgggga     2520

aagcggccgc gggcggcggt ggttctggtg gtggcgggag cacctcctgc gtcaaccccc     2580

ccaccgtgca gaacgcctac atcgtgtccc ggcagatgag caagtacccc tccggtgaga     2640

gggtgagata ccagtgccgt tccccctacg agatgttcgg ggacgaggag gtgatgtgcc     2700

tcaacggtaa ctggaccgag cccccccagt gcaaggactc caccggtaag tgtggacccc     2760

ccccccccat cgacaacggc gggatcacct ccttcccgct gtccgtctac gccccggcct     2820

cctccgtcga gtatcagtgc cagaacctgt accagctcga gggcaacaag aggatcacct     2880

gccgtaacgg tcagtggtcc gagcccccca agtgcctcca tccctgcgtg atcagccgtg     2940

agatcatgga gaactacaac atcgccctgc ggtggaccgc caagcagaag ctctactcca     3000

ggaccggcga gagcgtcgag tttgtgtgca agcgtggtta ccggctctcc tccaggtccc     3060

ataccctcag gaccacctgc tgggacggca agctcgagta ccccacctgt gccaagaggt     3120

aatctagagt ccgcaaaaat caccagtctc tctctacaaa tctatctctc tctatttttc     3180

tccagaataa tgtgtgagta gttcccagat aagggaatta gggttcttat agggtttcgc     3240

tcatgtgttg agcatataag aaacccttag tatgtatttg tatttgtaaa atacttctat     3300

caataaaatt tctaattcct aaaaccaaaa tccagtgacc gggcggccgg ccgcccctag     3360

aaatatttgc gactcttctg gcatgtaata tttcgttaaa tatgaagtgc tccattttta     3420

ttaactttaa ataattggtt gtacgatcac tttcttatca agcgttacta aaatgcgtca     3480

atctctttgt tcttccatat tcatatgtca aaatctatca aaattcttat atatcttttt     3540

cgaatttgaa gtgaaatttc gataatttaa aattaaatag aacatatcat tatttaggtg     3600

tcatattgat ttttatactt aattactaaa tttggttaac tttgaaagtg tacatcaacg     3660

aaaaattagt caaacgacta aaataaataa atatcatgtg ttattaagaa aattctccta     3720

taagaatatt ttaatagatc atatgtttgt aaaaaaaatt aatttttact aacacatata     3780

tttacttatc aaaaatttga caaagtaaga ttaaaataat attcatctaa caaaaaaaaa     3840

ccagaaaatg ctgaaaaccc ggcaaaaccg aaccaatcca aaccgatata gttggtttgg     3900

tttgattttg atataaaccg aaccaactcg gtccatttgc acccctaatc ataatagctt     3960

taatatttca agatattatt aagttaacgt tgtcaatatc ctggaaattt tgcaaaatga     4020

atcaagccta tatggctgta atatgaattt aaaagcagct cgatgtggtg gtaatatgta     4080

atttacttga ttctaaaaaa atatcccaag tattaataat ttctgctagg aagaaggtta     4140

gctacgattt acagcaaagc cagaatacaa agaaccataa agtgattgaa gctcgaaata     4200

tacgaaggaa caaatatttt taaaaaaata cgcaatgact tggaacaaaa gaaagtgata     4260

tattttttgt tcttaaacaa gcatcccctc taaagaatgg cagttttcct ttgcatgtaa     4320

ctattatgct cccttcgtta caaaaatttt ggactactat tgggcgggtg gagggggatc     4380

agattgtcgt ttcccgcctt cagtttaaac tatcagtgtt tgacaggata tattggcggg     4440

taaacctaag agaaaagagc gtttattaga ataatcggat atttaaaagg gcgtgaaaag     4500

gtttatccgt tcgtccattt gtatgtgtac atcaccgacg agcaaggcaa gaccgagcgc     4560

ctttccgacg ctcaccgggc tggttgccct cgccgctggg ctggcggccg tctatggccc     4620

tgcaaacgcg ccagaaacgc cgtcgaagcc gtgtgcgaga caccggccgc cggcgttgtg     4680

gatacctcgc ggaaaacttg gccctcactg acagatgagg ggcggacgtt gacacttgag     4740

gggccgactc acccggcgcg gcgttgacag atgaggggca ggctcgattt cggccggcga     4800

cgtggagctg gccagcctcg caaatcggcg aaaacgcctg attttacgcg agtttcccac     4860

agatgatgtg gacaagcctg gggataagtg ccctgcggta ttgacacttg aggggcgcga     4920

ctactgacag atgaggggcg cgatccttga cacttgaggg gcagagtgct gacagatgag     4980

gggcgcacct attgacattt gaggggctgt ccacaggcag aaaatccagc atttgcaagg     5040

gtttccgccc gtttttcggc caccgctaac ctgtctttta acctgctttt aaaccaatat     5100

ttataaacct tgtttttaac cagggctgcg ccctgtgcgc gtgaccgcgc acgccgaagg     5160

ggggtgcccc cccttctcga accctcccgg cccgctaacg cgggcctccc atccccccag     5220

gggctgcgcc cctcggccgc gaacggcctc accccaaaaa tggcagcgct ggcagtcctt     5280

gccattgccg ggatcggggc agtaacggga tgggcgatca gcccgacaag ctacccctat     5340

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     5400

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     5460

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     5520

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     5580

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     5640

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     5700

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     5760

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     5820

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     5880

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     5940

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     6000

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6060

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6120

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6180

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     6240

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     6300

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     6360

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6420

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6480

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6540

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6600

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     6660

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     6720

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     6780

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     6840

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     6900

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     6960

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     7020

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     7080

cctggccttt tgctggcctt ttgctcacat ggactctagc tagaggatca caggcagcaa     7140

cgctctgtca tcgttacaat caacatgcta ccctccgcga gatcatccgt gtttcaaacc     7200

cggcagctta gttgccgttc ttccgaatag catcggtaac atgagcaaag tctgccgcct     7260

tacaacggct ctcccgctga cgccgtcccg gactgatggg ctgcctgtat cgagtggtga     7320

ttttgtgccg agctgccggt cggggagctg ttggctggct ggtggcagga tatattgtgg     7380

tgtaaacaaa ttgacgctta gacaacttaa taacacattg cggacgtttt taatgatcga     7440

atactaacgt ctctaccaga tatcagcttg catgccggtc gatctagtaa catagatgac     7500

accgcgcgcg ataatttatc ctagtttgcg cgctatattt tgttttctat cgcgtattaa     7560

atgtataatt gcgggactct aatcataaaa acccatctca taaataacgt catgcattac     7620

atgttaatta ttacatgctt aacgtaattc aacagaaatt atatgataat catcgcaaga     7680

ccggcaacag gattcaatct taagaaactt tattgccaaa tgtttgaacg atctgcttga     7740

ctctagctag agtccgaacc ccagagtccc gctcagaaga actcgtcaag aaggcgatag     7800

aaggcgatgc gctgcgaatc gggagcggcg ataccgtaaa gcacgaggaa gcggtcagcc     7860

cattcgccgc caagctcttc agcaatatca cgggtagcca acgctatgtc ctgatagcgg     7920

tccgccacac ccagccggcc acagtcgatg aatccagaaa agcggccatt ttccaccatg     7980

atattcggca agcaggcatc gccgtgggtc acgacgagat cctcgccgtc gggcatccgc     8040

gccttgagcc tggcgaacag ttcggctggc gcgagcccct gatgctcttc gtccagatca     8100

tcctgatcga caagaccggc ttccatccga gtacgtgctc gctcgatgcg atgtttcgct     8160

tggtggtcga atgggcaggt agccggatca agcgtatgca gccgccgcat tgcatcagcc     8220

atgatggata ctttctcggc aggagcaagg tgagatgaca ggagatcctg ccccggcact     8280

tcgcccaata gcagccagtt ccttcccgct tcagtgacaa cgtcgagcac agctgcgcaa     8340

ggaacgcccg ttgtggccag ccacgatagc cgcgctgcct cgtcttggag ttcattcagg     8400

gcaccggaca ggtcggtctt gacaaaaaga accgggcgcc cctgcgctga cagccggaac     8460

acggcggcat cagagcagcc gattgtttgt tgtgcccagt catagccgaa tagcctctcc     8520

acccaagcgg ccggagaacc tgcgtgcaat ccatcttgtt caatcatgcc tcgatcgagt     8580

tgagagtgaa tatgagactc taattggata ccgaggggaa tttatggaac gtcagtggag     8640

catttttgac aagaaatatt tgctagctga tagtgacctt aggcgacttt tgaacgcgca     8700

ataatggttt ctgacgtatg tgcttagctc attaaactcc agaaacccgc ggctcagtgg     8760

ctccttcaac gttgcggttc tgtcagttcc aaacgtaaaa cggcttgtcc cgcgtcatcg     8820

gcgggggtca taacgtgact cccttaattc tccgctcatg atcgatatcc attgaagagc     8880

aagct                                                                 8885


<210>  18
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  18
cacctattga caatgggggc attacttcat tcccgtt                                37


<210>  19
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  19
gaattcgtgt gtgaatccgc ccacagtac                                         29


<210>  20
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  20
gccgcggggg gcgagcccaa atcttgtgac aa                                     32


<210>  21
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  21
agcccaaatc ttgtgacaaa actcacacat gccca                                  35


<210>  22
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  22
cgggtaaatg agtgctagct gg                                                22


<210>  23
<211>  62
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  23

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  24
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  24
gaaagcggcc gcgggcggcg gtggttctgg tggtggcggg agcgactcca ccggtaagtg       60

tgg                                                                     63


<210>  25
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  25
tttctctaga ttacctcttg gcacaggtgg                                        30


<210>  26
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  26
gaaagcggcc gcgggcggcg gtggttctgg tggtggcggg agccatccct gcgtgatcag       60

ccg                                                                     63


<210>  27
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  27
tttctctaga ttacctcttg gcacaggtgg                                        30


<210>  28
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  28
gagggttacg agctctcctc ctcctcccat accctcagga ccacc                       45


<210>  29
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  29
ggaggaggag agctcgtaac cctccttgca cacaaactcg acgc                        44


<210>  30
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  30
ctcggttaca acctctcctc ctcctcccat accctcagga ccacc                       45


<210>  31
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  31
ggaggaggag aggttgtaac cgagcttgca cacaaactcg acgc                        44


<210>  32
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  32
actctttaca ttaccaggga gcctgaagtt acttgcgttg tt                          42


<210>  33
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  33
aggctccctg gtaatgtaaa gagtgtcctt tggcttagg                              39


<210>  34
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  34
tctgttcttc atgaagcatt acattctcac ttcactcaaa agtctctt                    48


<210>  35
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  35
gtgagaatgt aatgcttcat gaagaacaga gcaactgaaa atatt                       45


<210>  36
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  36

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Met Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  37
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  37
ctgcaggtgt tcactcc                                                      17


<210>  38
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  38

Gly Gly Gly Gly Ser 
1               5   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  40

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  41
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  41

Gly Gly Gly Gly Ser Ser 
1               5       


<210>  42
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  42

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  43

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


