                               SEQUENCE LISTING

<110> OBSIDIAN THERAPEUTICS, INC.
 
<120> COMPOSITIONS AND METHODS FOR EXPRESSION OF ANTI-BCMA CHIMERIC 
      ANTIGEN RECEPTORS WITH SMALL MOLECULE-REGULATED IL15 IN T CELLS

<130> 268052-497677

<140>
<141>

<150> 63/110,287
<151> 2020-11-05

<150> 63/079,472
<151> 2020-09-16

<160> 52    

<170> PatentIn version 3.5

<210> 1
<211> 260
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210> 2
<211> 259
<212> PRT
<213> Homo sapiens

<400> 2
Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
1               5                   10                  15      


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
            20                  25                  30          


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
        35                  40                  45              


Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
    50                  55                  60                  


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                85                  90                  95      


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
            100                 105                 110         


Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
        115                 120                 125             


Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
    130                 135                 140                 


Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp 
145                 150                 155                 160 


Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
                165                 170                 175     


Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
            180                 185                 190         


Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
        195                 200                 205             


Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
    210                 215                 220                 


Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
225                 230                 235                 240 


Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
                245                 250                 255     


Ser Phe Lys 
            


<210> 3
<211> 780
<212> DNA
<213> Homo sapiens

<400> 3
atgtcccatc actgggggta cggcaaacac aacggacctg agcactggca taaggacttc       60

cccattgcca agggagagcg ccagtcccct gttgacatcg acactcatac agccaagtat      120

gacccttccc tgaagcccct gtctgtttcc tatgatcaag caacttccct gaggatcctc      180

aacaatggtc atgctttcaa cgtggagttt gatgactctc aggacaaagc agtgctcaag      240

ggaggacccc tggatggcac ttacagattg attcagtttc actttcactg gggttcactt      300

gatggacaag gttcagagca tactgtggat aaaaagaaat atgctgcaga acttcacttg      360

gttcactgga acaccaaata tggggatttt gggaaagctg tgcagcaacc tgatggactg      420

gccgttctag gtattttttt gaaggttggc agcgctaaac cgggccttca gaaagttgtt      480

gatgtgctgg attccattaa aacaaagggc aagagtgctg acttcactaa cttcgatcct      540

cgtggcctcc ttcctgaatc cctggattac tggacctacc caggctcact gaccacccct      600

cctcttctgg aatgtgtgac ctggattgtg ctcaaggaac ccatcagcgt cagcagcgag      660

caggtgttga aattccgtaa acttaacttc aatggggagg gtgaacccga agaactgatg      720

gtggacaact ggcgcccagc tcagccactg aagaacaggc aaatcaaagc ttccttcaaa      780


<210> 4
<211> 259
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
1               5                   10                  15      


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
            20                  25                  30          


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
        35                  40                  45              


Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
    50                  55                  60                  


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
                85                  90                  95      


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
            100                 105                 110         


Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
        115                 120                 125             


Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
    130                 135                 140                 


Phe Leu Lys Val Gly Ser Ala Lys Pro Gly His Gln Lys Val Val Asp 
145                 150                 155                 160 


Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
                165                 170                 175     


Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
            180                 185                 190         


Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
        195                 200                 205             


Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
    210                 215                 220                 


Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
225                 230                 235                 240 


Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
                245                 250                 255     


Ser Phe Lys 
            


<210> 5
<211> 777
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
tcccatcact gggggtacgg caaacacaac ggacctgagc actggcataa ggacttcccc       60

attgccaagg gagagcgcca gtcccctgtt gacatcgaca ctcatacagc caagtatgac      120

ccttccctga agcccctgtc tgtttcctat gatcaagcaa cttccctgag aatcctcaac      180

aatggtcatg ctttcaacgt ggagtttgat gactctcagg acaaagcagt gctcaaggga      240

ggacccctgg atggcactta cagattgatt cagtttcact ttcactgggg ttcacttgat      300

ggacaaggtt cagagcatac tgtggataaa aagaaatatg ctgcagaact tcacttggtt      360

cactggaaca ccaaatatgg ggattttggg aaagctgtgc agcaacctga tggactggcc      420

gttctaggta tttttttgaa ggttggcagc gctaaaccgg gccatcagaa agttgttgat      480

gtgctggatt ccattaaaac aaagggcaag agtgctgact tcactaactt cgatcctcgt      540

ggcctccttc ctgaatccct ggattactgg acctacccag gctcactgac cacccctcct      600

cttctggaat gtgtgacctg gattgtgctc aaggaaccca tcagcgtcag cagcgagcag      660

gtgttgaaat tccgtaaact taacttcaat ggggagggtg aacccgaaga actgatggtg      720

gacaactggc gcccagctca gccactgaag aacaggcaaa tcaaagcttc cttcaaa         777


<210> 6
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
    210                 215                 220 


<210> 7
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660


<210> 8
<211> 114
<212> PRT
<213> Homo sapiens

<400> 8
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 9
<211> 342
<212> DNA
<213> Homo sapiens

<400> 9
aattgggtaa atgttatcag tgatctcaag aagatagagg atctcatcca gtccatgcat       60

attgatgcca cgctgtacac agaaagcgat gtgcatccta gctgtaaggt gacagcgatg      120

aagtgttttc ttttggagct gcaggtaatt agtcttgagt ccggcgatgc cagcattcat      180

gataccgtag aaaacttgat tatcctggcc aacaattctc tgtcctcaaa cggaaacgta      240

accgagagcg gttgtaaaga atgtgaagaa ctggaagaaa agaacatcaa ggagtttctg      300

caatcattcg ttcacatcgt acaaatgttc ataaatacgt ca                         342


<210> 10
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
    210                 215                 220 


<210> 11
<211> 660
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660


<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro 
            20  


<210> 13
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gctctgcctg tgacagctct gctgctgcct ctggctctgc ttctgcatgc cgccagacct       60


<210> 14
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Ser Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser 
                245     


<210> 15
<211> 738
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gacatcgtgc tgacacagtc tccagccagc ctggccatgt ctctgggaaa gagagccacc       60

atcagctgca gagcctctga gagcgtgtcc gtgattggag cccacctgat ccactggtat      120

cagcagaagc ctggacagcc tcctaagctg ctgatctacc tggccagcaa cctggaaaca      180

ggcgtgccag ccagattttc tggcagcggc tctggcaccg acttcaccct gacaatcgac      240

cccgtggaag aggacgacgt ggccatctac agctgcctgc agagcagaat cttccccaga      300

acctttggcg gaggcaccaa gctggaaatc aagggcagca caagcggcag cggcaaacct      360

ggatctggcg agggatctac caagggacag atccagctgg tgcagtctgg ccccgagctg      420

aagaaacctg gcgagacagt gaagatctcc tgcaaggcca gcggctacac cttcaccgac      480

tacagcatca actgggtcaa gagagcccct ggcaagggcc tgaaatggat gggctggatc      540

aacaccgaaa ccagagagcc cgcctacgcc tacgacttca gaggcagatt cgccttcagc      600

ctggaaacca gcgccagcac agcctacctg cagatcaaca acctgaagta cgaggacacc      660

gccacctact tttgcgccct ggattacagc tacgccatgg actattgggg ccagggcaca      720

agcgtgaccg tgtcctct                                                    738


<210> 16
<211> 69
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210> 17
<211> 207
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
acaacaaccc ctgctcctcg gcctcctaca ccagctccta caattgcctc tcagcccctg       60

tctctgaggc ccgaagcttg tagacctgct gctggcggag ccgtgcatac aagaggactg      120

gatttcgcct gcgacatcta catctgggcc cctctggctg gaacatgtgg cgtgctgctg      180

ctgagcctgg tcatcaccct gtactgc                                          207


<210> 18
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 19
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
aagcggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag       60

accacacaag aggaagatgg ctgctcctgc agattccctg aggaagaaga aggcggctgc      120

gagctg                                                                 126


<210> 20
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 21
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
agagtgaagt tcagcagatc cgccgacgct cccgcctata agcagggaca gaatcagctc       60

tacaacgagc tgaacctggg gcgcagagaa gagtacgatg tgctggacaa gcggagaggc      120

agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtacaat      180

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgaacgc      240

agaagaggca agggacacga tggcctgtat cagggcctga gcaccgccac aaaggacacc      300

tatgatgccc tgcacatgca ggccctgcct ccaaga                                336


<210> 22
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 23
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gctaccaatt ttagtctttt gaagcaagcc ggagacgtcg aagagaaccc gggtccc          57


<210> 24
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210> 25
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgt                                                                  66


<210> 26
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30  


<210> 27
<211> 90
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
ggatctggtt ctggttccgg aagtggatct ggttcagggt ccggtagtgg atctgggtca       60

ggaagtggaa gcggtagtgg gtctggatct                                        90


<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Lys Gln Glu His Phe Pro Asp Asn 
1               5               


<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
aaacaagagc actttcctga taac                                              24


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
1               5                   10                  15      


Val Ile Cys Cys Leu 
            20      


<210> 31
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ctgttgccga gctgggcgat tacgcttatc agtgtaaacg gcatctttgt aatatgctgt       60

ctg                                                                     63


<210> 32
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg 
1               5                   10                  15      


Leu Arg Arg Glu Ser Val Arg Pro Val 
            20                  25  


<210> 33
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
acctactgct tcgcaccaag gtgccgggag agaaggagaa atgaaagact gagaagggag       60

agcgtgagac ctgtg                                                        75


<210> 34
<211> 490
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Ser 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210> 35
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctgacatcg tgctgacaca gtctccagcc agcctggcca tgtctctggg aaagagagcc      120

accatcagct gcagagcctc tgagagcgtg tccgtgattg gagcccacct gatccactgg      180

tatcagcaga agcctggaca gcctcctaag ctgctgatct acctggccag caacctggaa      240

acaggcgtgc cagccagatt ttctggcagc ggctctggca ccgacttcac cctgacaatc      300

gaccccgtgg aagaggacga cgtggccatc tacagctgcc tgcagagcag aatcttcccc      360

agaacctttg gcggaggcac caagctggaa atcaagggca gcacaagcgg cagcggcaaa      420

cctggatctg gcgagggatc taccaaggga cagatccagc tggtgcagtc tggccccgag      480

ctgaagaaac ctggcgagac agtgaagatc tcctgcaagg ccagcggcta caccttcacc      540

gactacagca tcaactgggt caagagagcc cctggcaagg gcctgaaatg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctac gcctacgact tcagaggcag attcgccttc      660

agcctggaaa ccagcgccag cacagcctac ctgcagatca acaacctgaa gtacgaggac      720

accgccacct acttttgcgc cctggattac agctacgcca tggactattg gggccagggc      780

acaagcgtga ccgtgtcctc tacaacaacc cctgctcctc ggcctcctac accagctcct      840

acaattgcct ctcagcccct gtctctgagg cccgaagctt gtagacctgc tgctggcgga      900

gccgtgcata caagaggact ggatttcgcc tgcgacatct acatctgggc ccctctggct      960

ggaacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtactgcaa gcggggcaga     1020

aagaagctgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac cacacaagag     1080

gaagatggct gctcctgcag attccctgag gaagaagaag gcggctgcga gctgagagtg     1140

aagttcagca gatccgccga cgctcccgcc tataagcagg gacagaatca gctctacaac     1200

gagctgaacc tggggcgcag agaagagtac gatgtgctgg acaagcggag aggcagagat     1260

cctgagatgg gcggcaagcc cagacggaag aatcctcaag agggcctgta caatgagctg     1320

cagaaagaca agatggccga ggcctacagc gagatcggaa tgaagggcga acgcagaaga     1380

ggcaagggac acgatggcct gtatcagggc ctgagcaccg ccacaaagga cacctatgat     1440

gccctgcaca tgcaggccct gcctccaaga                                      1470


<210> 36
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Ser 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
                485                 490                 495     


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            500                 505                 510         


Gly Ser Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu 
        515                 520                 525             


Leu Trp Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp 
    530                 535                 540                 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
545                 550                 555                 560 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                565                 570                 575     


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
            580                 585                 590         


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
        595                 600                 605             


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
    610                 615                 620                 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
625                 630                 635                 640 


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser 
                645                 650                 655     


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            660                 665                 670         


Gly Ser Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn 
        675                 680                 685             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    690                 695                 700                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
705                 710                 715                 720 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser 
                725                 730                 735     


<210> 37
<211> 2211
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctgacatcg tgctgacaca gtctccagcc agcctggcca tgtctctggg aaagagagcc      120

accatcagct gcagagcctc tgagagcgtg tccgtgattg gagcccacct gatccactgg      180

tatcagcaga agcctggaca gcctcctaag ctgctgatct acctggccag caacctggaa      240

acaggcgtgc cagccagatt ttctggcagc ggctctggca ccgacttcac cctgacaatc      300

gaccccgtgg aagaggacga cgtggccatc tacagctgcc tgcagagcag aatcttcccc      360

agaacctttg gcggaggcac caagctggaa atcaagggca gcacaagcgg cagcggcaaa      420

cctggatctg gcgagggatc taccaaggga cagatccagc tggtgcagtc tggccccgag      480

ctgaagaaac ctggcgagac agtgaagatc tcctgcaagg ccagcggcta caccttcacc      540

gactacagca tcaactgggt caagagagcc cctggcaagg gcctgaaatg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctac gcctacgact tcagaggcag attcgccttc      660

agcctggaaa ccagcgccag cacagcctac ctgcagatca acaacctgaa gtacgaggac      720

accgccacct acttttgcgc cctggattac agctacgcca tggactattg gggccagggc      780

acaagcgtga ccgtgtcctc tacaacaacc cctgctcctc ggcctcctac accagctcct      840

acaattgcct ctcagcccct gtctctgagg cccgaagctt gtagacctgc tgctggcgga      900

gccgtgcata caagaggact ggatttcgcc tgcgacatct acatctgggc ccctctggct      960

ggaacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtactgcaa gcggggcaga     1020

aagaagctgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac cacacaagag     1080

gaagatggct gctcctgcag attccctgag gaagaagaag gcggctgcga gctgagagtg     1140

aagttcagca gatccgccga cgctcccgcc tataagcagg gacagaatca gctctacaac     1200

gagctgaacc tggggcgcag agaagagtac gatgtgctgg acaagcggag aggcagagat     1260

cctgagatgg gcggcaagcc cagacggaag aatcctcaag agggcctgta caatgagctg     1320

cagaaagaca agatggccga ggcctacagc gagatcggaa tgaagggcga acgcagaaga     1380

ggcaagggac acgatggcct gtatcagggc ctgagcaccg ccacaaagga cacctatgat     1440

gccctgcaca tgcaggccct gcctccaaga ggatctggtg ctaccaattt tagtcttttg     1500

aagcaagccg gagacgtcga agagaacccg ggtcccggat ctatggacat gcgggtgcct     1560

gcacaacttc tgggcctgct gttgttgtgg ctgtctggag cccggtgtaa ttgggtaaat     1620

gttatcagtg atctcaagaa gatagaggat ctcatccagt ccatgcatat tgatgccacg     1680

ctgtacacag aaagcgatgt gcatcctagc tgtaaggtga cagcgatgaa gtgttttctt     1740

ttggagctgc aggtaattag tcttgagtcc ggcgatgcca gcattcatga taccgtagaa     1800

aacttgatta tcctggccaa caattctctg tcctcaaacg gaaacgtaac cgagagcggt     1860

tgtaaagaat gtgaagaact ggaagaaaag aacatcaagg agtttctgca atcattcgtt     1920

cacatcgtac aaatgttcat aaatacgtca ggatctggtt ctggttccgg aagtggatct     1980

ggttcagggt ccggtagtgg atctgggtca ggaagtggaa gcggtagtgg gtctggatct     2040

aaacaagagc actttcctga taacctgttg ccgagctggg cgattacgct tatcagtgta     2100

aacggcatct ttgtaatatg ctgtctgacc tactgcttcg caccaaggtg ccgggagaga     2160

aggagaaatg aaagactgag aagggagagc gtgagacctg tgggatccta a              2211


<210> 38
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Ser 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
                485                 490                 495     


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            500                 505                 510         


Gly Ser Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu 
        515                 520                 525             


Leu Trp Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp 
    530                 535                 540                 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
545                 550                 555                 560 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                565                 570                 575     


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
            580                 585                 590         


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
        595                 600                 605             


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
    610                 615                 620                 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
625                 630                 635                 640 


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser 
                645                 650                 655     


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            660                 665                 670         


Gly Ser Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn 
        675                 680                 685             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    690                 695                 700                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
705                 710                 715                 720 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser 
                725                 730                 735     


Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
            740                 745                 750         


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
        755                 760                 765             


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
    770                 775                 780                 


Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
785                 790                 795                 800 


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
                805                 810                 815     


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
            820                 825                 830         


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
        835                 840                 845             


Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
    850                 855                 860                 


Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
865                 870                 875                 880 


Phe Leu Lys Val Gly Ser Ala Lys Pro Gly His Gln Lys Val Val Asp 
                885                 890                 895     


Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
            900                 905                 910         


Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
        915                 920                 925             


Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
    930                 935                 940                 


Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
945                 950                 955                 960 


Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
                965                 970                 975     


Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
            980                 985                 990         


Ser Phe Lys 
        995 


<210> 39
<211> 2988
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctgacatcg tgctgacaca gtctccagcc agcctggcca tgtctctggg aaagagagcc      120

accatcagct gcagagcctc tgagagcgtg tccgtgattg gagcccacct gatccactgg      180

tatcagcaga agcctggaca gcctcctaag ctgctgatct acctggccag caacctggaa      240

acaggcgtgc cagccagatt ttctggcagc ggctctggca ccgacttcac cctgacaatc      300

gaccccgtgg aagaggacga cgtggccatc tacagctgcc tgcagagcag aatcttcccc      360

agaacctttg gcggaggcac caagctggaa atcaagggca gcacaagcgg cagcggcaaa      420

cctggatctg gcgagggatc taccaaggga cagatccagc tggtgcagtc tggccccgag      480

ctgaagaaac ctggcgagac agtgaagatc tcctgcaagg ccagcggcta caccttcacc      540

gactacagca tcaactgggt caagagagcc cctggcaagg gcctgaaatg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctac gcctacgact tcagaggcag attcgccttc      660

agcctggaaa ccagcgccag cacagcctac ctgcagatca acaacctgaa gtacgaggac      720

accgccacct acttttgcgc cctggattac agctacgcca tggactattg gggccagggc      780

acaagcgtga ccgtgtcctc tacaacaacc cctgctcctc ggcctcctac accagctcct      840

acaattgcct ctcagcccct gtctctgagg cccgaagctt gtagacctgc tgctggcgga      900

gccgtgcata caagaggact ggatttcgcc tgcgacatct acatctgggc ccctctggct      960

ggaacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtactgcaa gcggggcaga     1020

aagaagctgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac cacacaagag     1080

gaagatggct gctcctgcag attccctgag gaagaagaag gcggctgcga gctgagagtg     1140

aagttcagca gatccgccga cgctcccgcc tataagcagg gacagaatca gctctacaac     1200

gagctgaacc tggggcgcag agaagagtac gatgtgctgg acaagcggag aggcagagat     1260

cctgagatgg gcggcaagcc cagacggaag aatcctcaag agggcctgta caatgagctg     1320

cagaaagaca agatggccga ggcctacagc gagatcggaa tgaagggcga acgcagaaga     1380

ggcaagggac acgatggcct gtatcagggc ctgagcaccg ccacaaagga cacctatgat     1440

gccctgcaca tgcaggccct gcctccaaga ggatctggtg ctaccaattt tagtcttttg     1500

aagcaagccg gagacgtcga agagaacccg ggtcccggat ctatggacat gcgggtgcct     1560

gcacaacttc tgggcctgct gttgttgtgg ctgtctggag cccggtgtaa ttgggtaaat     1620

gttatcagtg atctcaagaa gatagaggat ctcatccagt ccatgcatat tgatgccacg     1680

ctgtacacag aaagcgatgt gcatcctagc tgtaaggtga cagcgatgaa gtgttttctt     1740

ttggagctgc aggtaattag tcttgagtcc ggcgatgcca gcattcatga taccgtagaa     1800

aacttgatta tcctggccaa caattctctg tcctcaaacg gaaacgtaac cgagagcggt     1860

tgtaaagaat gtgaagaact ggaagaaaag aacatcaagg agtttctgca atcattcgtt     1920

cacatcgtac aaatgttcat aaatacgtca ggatctggtt ctggttccgg aagtggatct     1980

ggttcagggt ccggtagtgg atctgggtca ggaagtggaa gcggtagtgg gtctggatct     2040

aaacaagagc actttcctga taacctgttg ccgagctggg cgattacgct tatcagtgta     2100

aacggcatct ttgtaatatg ctgtctgacc tactgcttcg caccaaggtg ccgggagaga     2160

aggagaaatg aaagactgag aagggagagc gtgagacctg tgggatcctc ccatcactgg     2220

gggtacggca aacacaacgg acctgagcac tggcataagg acttccccat tgccaaggga     2280

gagcgccagt cccctgttga catcgacact catacagcca agtatgaccc ttccctgaag     2340

cccctgtctg tttcctatga tcaagcaact tccctgagaa tcctcaacaa tggtcatgct     2400

ttcaacgtgg agtttgatga ctctcaggac aaagcagtgc tcaagggagg acccctggat     2460

ggcacttaca gattgattca gtttcacttt cactggggtt cacttgatgg acaaggttca     2520

gagcatactg tggataaaaa gaaatatgct gcagaacttc acttggttca ctggaacacc     2580

aaatatgggg attttgggaa agctgtgcag caacctgatg gactggccgt tctaggtatt     2640

tttttgaagg ttggcagcgc taaaccgggc catcagaaag ttgttgatgt gctggattcc     2700

attaaaacaa agggcaagag tgctgacttc actaacttcg atcctcgtgg cctccttcct     2760

gaatccctgg attactggac ctacccaggc tcactgacca cccctcctct tctggaatgt     2820

gtgacctgga ttgtgctcaa ggaacccatc agcgtcagca gcgagcaggt gttgaaattc     2880

cgtaaactta acttcaatgg ggagggtgaa cccgaagaac tgatggtgga caactggcgc     2940

ccagctcagc cactgaagaa caggcaaatc aaagcttcct tcaaataa                  2988


<210> 40
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Ser 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
                485                 490                 495     


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            500                 505                 510         


Gly Ser Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu 
        515                 520                 525             


Leu Trp Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp 
    530                 535                 540                 


Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr 
545                 550                 555                 560 


Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met 
                565                 570                 575     


Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp 
            580                 585                 590         


Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn 
        595                 600                 605             


Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys 
    610                 615                 620                 


Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val 
625                 630                 635                 640 


His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser 
                645                 650                 655     


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            660                 665                 670         


Gly Ser Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn 
        675                 680                 685             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    690                 695                 700                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
705                 710                 715                 720 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser 
                725                 730                 735     


Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His 
            740                 745                 750         


Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile 
        755                 760                 765             


Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val 
    770                 775                 780                 


Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala 
785                 790                 795                 800 


Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly 
                805                 810                 815     


Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp 
            820                 825                 830         


Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys 
        835                 840                 845             


Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp 
    850                 855                 860                 


Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile 
865                 870                 875                 880 


Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp 
                885                 890                 895     


Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn 
            900                 905                 910         


Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr 
        915                 920                 925             


Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile 
    930                 935                 940                 


Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe 
945                 950                 955                 960 


Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val 
                965                 970                 975     


Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala 
            980                 985                 990         


Ser Phe Lys 
        995 


<210> 41
<211> 2988
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctgacatcg tgctgacaca gtctccagcc agcctggcca tgtctctggg aaagagagcc      120

accatcagct gcagagcctc tgagagcgtg tccgtgattg gagcccacct gatccactgg      180

tatcagcaga agcctggaca gcctcctaag ctgctgatct acctggccag caacctggaa      240

acaggcgtgc cagccagatt ttctggcagc ggctctggca ccgacttcac cctgacaatc      300

gaccccgtgg aagaggacga cgtggccatc tacagctgcc tgcagagcag aatcttcccc      360

agaacctttg gcggaggcac caagctggaa atcaagggca gcacaagcgg cagcggcaaa      420

cctggatctg gcgagggatc taccaaggga cagatccagc tggtgcagtc tggccccgag      480

ctgaagaaac ctggcgagac agtgaagatc tcctgcaagg ccagcggcta caccttcacc      540

gactacagca tcaactgggt caagagagcc cctggcaagg gcctgaaatg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctac gcctacgact tcagaggcag attcgccttc      660

agcctggaaa ccagcgccag cacagcctac ctgcagatca acaacctgaa gtacgaggac      720

accgccacct acttttgcgc cctggattac agctacgcca tggactattg gggccagggc      780

acaagcgtga ccgtgtcctc tacaacaacc cctgctcctc ggcctcctac accagctcct      840

acaattgcct ctcagcccct gtctctgagg cccgaagctt gtagacctgc tgctggcgga      900

gccgtgcata caagaggact ggatttcgcc tgcgacatct acatctgggc ccctctggct      960

ggaacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtactgcaa gcggggcaga     1020

aagaagctgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac cacacaagag     1080

gaagatggct gctcctgcag attccctgag gaagaagaag gcggctgcga gctgagagtg     1140

aagttcagca gatccgccga cgctcccgcc tataagcagg gacagaatca gctctacaac     1200

gagctgaacc tggggcgcag agaagagtac gatgtgctgg acaagcggag aggcagagat     1260

cctgagatgg gcggcaagcc cagacggaag aatcctcaag agggcctgta caatgagctg     1320

cagaaagaca agatggccga ggcctacagc gagatcggaa tgaagggcga acgcagaaga     1380

ggcaagggac acgatggcct gtatcagggc ctgagcaccg ccacaaagga cacctatgat     1440

gccctgcaca tgcaggccct gcctccaaga ggatctggtg ctaccaattt tagtcttttg     1500

aagcaagccg gagacgtcga agagaacccg ggtcccggat ctatggacat gcgggtgcct     1560

gcacaacttc tgggcctgct gttgttgtgg ctgtctggag cccggtgtaa ttgggtaaat     1620

gttatcagtg atctcaagaa gatagaggat ctcatccagt ccatgcatat tgatgccacg     1680

ctgtacacag aaagcgatgt gcatcctagc tgtaaggtga cagcgatgaa gtgttttctt     1740

ttggagctgc aggtaattag tcttgagtcc ggcgatgcca gcattcatga taccgtagaa     1800

aacttgatta tcctggccaa caattctctg tcctcaaacg gaaacgtaac cgagagcggt     1860

tgtaaagaat gtgaagaact ggaagaaaag aacatcaagg agtttctgca atcattcgtt     1920

cacatcgtac aaatgttcat aaatacgtca ggatctggtt ctggttccgg aagtggatct     1980

ggttcagggt ccggtagtgg atctgggtca ggaagtggaa gcggtagtgg gtctggatct     2040

aaacaagagc actttcctga taacctgttg ccgagctggg cgattacgct tatcagtgta     2100

aacggcatct ttgtaatatg ctgtctgacc tactgcttcg caccaaggtg ccgggagaga     2160

aggagaaatg aaagactgag aagggagagc gtgagacctg tgggatcctc ccatcactgg     2220

gggtacggca aacacaacgg acctgagcac tggcataagg acttccccat tgccaaggga     2280

gagcgccagt cccctgttga catcgacact catacagcca agtatgaccc ttccctgaag     2340

cccctgtctg tttcctatga tcaagcaact tccctgagga tcctcaacaa tggtcatgct     2400

ttcaacgtgg agtttgatga ctctcaggac aaagcagtgc tcaagggagg acccctggat     2460

ggcacttaca gattgattca gtttcacttt cactggggtt cacttgatgg acaaggttca     2520

gagcatactg tggataaaaa gaaatatgct gcagaacttc acttggttca ctggaacacc     2580

aaatatgggg attttgggaa agctgtgcag caacctgatg gactggccgt tctaggtatt     2640

tttttgaagg ttggcagcgc taaaccgggc cttcagaaag ttgttgatgt gctggattcc     2700

attaaaacaa agggcaagag tgctgacttc actaacttcg atcctcgtgg cctccttcct     2760

gaatccctgg attactggac ctacccaggc tcactgacca cccctcctct tctggaatgt     2820

gtgacctgga ttgtgctcaa ggaacccatc agcgtcagca gcgagcaggt gttgaaattc     2880

cgtaaactta acttcaatgg ggagggtgaa cccgaagaac tgatggtgga caactggcgc     2940

ccagctcagc cactgaagaa caggcaaatc aaagcttcct tcaaataa                  2988


<210> 42
<211> 734
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser Gly Ala 
    210                 215                 220                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
225                 230                 235                 240 


Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
                245                 250                 255     


Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser 
            260                 265                 270         


Pro Ala Ser Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys 
        275                 280                 285             


Arg Ala Ser Glu Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp 
    290                 295                 300                 


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala 
305                 310                 315                 320 


Ser Asn Leu Glu Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val 
            340                 345                 350         


Ala Ile Tyr Ser Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly 
        355                 360                 365             


Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys 
    370                 375                 380                 


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln 
385                 390                 395                 400 


Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys 
            420                 425                 430         


Arg Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu 
        435                 440                 445             


Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe 
    450                 455                 460                 


Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu 
465                 470                 475                 480 


Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr 
                485                 490                 495     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            500                 505                 510         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        515                 520                 525             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    530                 535                 540                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
545                 550                 555                 560 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                565                 570                 575     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            580                 585                 590         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        595                 600                 605             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    610                 615                 620                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
625                 630                 635                 640 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                645                 650                 655     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            660                 665                 670         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        675                 680                 685             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    690                 695                 700                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
705                 710                 715                 720 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 


<210> 43
<211> 2205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660

ggatccggag ctaccaattt tagtcttttg aagcaagccg gagacgtcga agagaacccg      720

ggtcccggat ctatggctct gcctgtgaca gctctgctgc tgcctctggc tctgcttctg      780

catgccgcca gacctgacat cgtgctgaca cagtctccag ccagcctggc catgtctctg      840

ggaaagagag ccaccatcag ctgcagagcc tctgagagcg tgtccgtgat tggagcccac      900

ctgatccact ggtatcagca gaagcctgga cagcctccta agctgctgat ctacctggcc      960

agcaacctgg aaacaggcgt gccagccaga ttttctggca gcggctctgg caccgacttc     1020

accctgacaa tcgaccccgt ggaagaggac gacgtggcca tctacagctg cctgcagagc     1080

agaatcttcc ccagaacctt tggcggaggc accaagctgg aaatcaaggg cagcacaagc     1140

ggcagcggca aacctggatc tggcgaggga tctaccaagg gacagatcca gctggtgcag     1200

tctggccccg agctgaagaa acctggcgag acagtgaaga tctcctgcaa ggccagcggc     1260

tacaccttca ccgactacag catcaactgg gtcaagagag cccctggcaa gggcctgaaa     1320

tggatgggct ggatcaacac cgaaaccaga gagcccgcct acgcctacga cttcagaggc     1380

agattcgcct tcagcctgga aaccagcgcc agcacagcct acctgcagat caacaacctg     1440

aagtacgagg acaccgccac ctacttttgc gccctggatt acagctacgc catggactat     1500

tggggccagg gcacaagcgt gaccgtgtcc tctacaacaa cccctgctcc tcggcctcct     1560

acaccagctc ctacaattgc ctctcagccc ctgtctctga ggcccgaagc ttgtagacct     1620

gctgctggcg gagccgtgca tacaagagga ctggatttcg cctgcgacat ctacatctgg     1680

gcccctctgg ctggaacatg tggcgtgctg ctgctgagcc tggtcatcac cctgtactgc     1740

aagcggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag     1800

accacacaag aggaagatgg ctgctcctgc agattccctg aggaagaaga aggcggctgc     1860

gagctgagag tgaagttcag cagatccgcc gacgctcccg cctataagca gggacagaat     1920

cagctctaca acgagctgaa cctggggcgc agagaagagt acgatgtgct ggacaagcgg     1980

agaggcagag atcctgagat gggcggcaag cccagacgga agaatcctca agagggcctg     2040

tacaatgagc tgcagaaaga caagatggcc gaggcctaca gcgagatcgg aatgaagggc     2100

gaacgcagaa gaggcaaggg acacgatggc ctgtatcagg gcctgagcac cgccacaaag     2160

gacacctatg atgccctgca catgcaggcc ctgcctccaa gataa                     2205


<210> 44
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser Ser His 
    210                 215                 220                 


His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His Lys Asp 
225                 230                 235                 240 


Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile Asp Thr 
                245                 250                 255     


His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val Ser Tyr 
            260                 265                 270         


Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala Phe Asn 
        275                 280                 285             


Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly Gly Pro 
    290                 295                 300                 


Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp Gly Ser 
305                 310                 315                 320 


Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys Tyr Ala 
                325                 330                 335     


Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp Phe Gly 
            340                 345                 350         


Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile Phe Leu 
        355                 360                 365             


Lys Val Gly Ser Ala Lys Pro Gly His Gln Lys Val Val Asp Val Leu 
    370                 375                 380                 


Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn Phe Asp 
385                 390                 395                 400 


Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr Pro Gly 
                405                 410                 415     


Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile Val Leu 
            420                 425                 430         


Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe Arg Lys 
        435                 440                 445             


Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val Asp Asn 
    450                 455                 460                 


Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala Ser Phe 
465                 470                 475                 480 


Lys Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
            500                 505                 510         


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile 
        515                 520                 525             


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly Lys Arg 
    530                 535                 540                 


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ile Gly Ala 
545                 550                 555                 560 


His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
                565                 570                 575     


Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val 
        595                 600                 605             


Glu Glu Asp Asp Val Ala Ile Tyr Ser Cys Leu Gln Ser Arg Ile Phe 
    610                 615                 620                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr 
625                 630                 635                 640 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln 
                645                 650                 655     


Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
            660                 665                 670         


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser 
        675                 680                 685             


Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
    690                 695                 700                 


Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg 
705                 710                 715                 720 


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
                725                 730                 735     


Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            740                 745                 750         


Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
        755                 760                 765             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        835                 840                 845             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    850                 855                 860                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
865                 870                 875                 880 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                885                 890                 895     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            900                 905                 910         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        915                 920                 925             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210> 45
<211> 2988
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660

ggatcctccc atcactgggg gtacggcaaa cacaacggac ctgagcactg gcataaggac      720

ttccccattg ccaagggaga gcgccagtcc cctgttgaca tcgacactca tacagccaag      780

tatgaccctt ccctgaagcc cctgtctgtt tcctatgatc aagcaacttc cctgagaatc      840

ctcaacaatg gtcatgcttt caacgtggag tttgatgact ctcaggacaa agcagtgctc      900

aagggaggac ccctggatgg cacttacaga ttgattcagt ttcactttca ctggggttca      960

cttgatggac aaggttcaga gcatactgtg gataaaaaga aatatgctgc agaacttcac     1020

ttggttcact ggaacaccaa atatggggat tttgggaaag ctgtgcagca acctgatgga     1080

ctggccgttc taggtatttt tttgaaggtt ggcagcgcta aaccgggcca tcagaaagtt     1140

gttgatgtgc tggattccat taaaacaaag ggcaagagtg ctgacttcac taacttcgat     1200

cctcgtggcc tccttcctga atccctggat tactggacct acccaggctc actgaccacc     1260

cctcctcttc tggaatgtgt gacctggatt gtgctcaagg aacccatcag cgtcagcagc     1320

gagcaggtgt tgaaattccg taaacttaac ttcaatgggg agggtgaacc cgaagaactg     1380

atggtggaca actggcgccc agctcagcca ctgaagaaca ggcaaatcaa agcttccttc     1440

aaaggatccg gagctaccaa ttttagtctt ttgaagcaag ccggagacgt cgaagagaac     1500

ccgggtcccg gatctatggc tctgcctgtg acagctctgc tgctgcctct ggctctgctt     1560

ctgcatgccg ccagacctga catcgtgctg acacagtctc cagccagcct ggccatgtct     1620

ctgggaaaga gagccaccat cagctgcaga gcctctgaga gcgtgtccgt gattggagcc     1680

cacctgatcc actggtatca gcagaagcct ggacagcctc ctaagctgct gatctacctg     1740

gccagcaacc tggaaacagg cgtgccagcc agattttctg gcagcggctc tggcaccgac     1800

ttcaccctga caatcgaccc cgtggaagag gacgacgtgg ccatctacag ctgcctgcag     1860

agcagaatct tccccagaac ctttggcgga ggcaccaagc tggaaatcaa gggcagcaca     1920

agcggcagcg gcaaacctgg atctggcgag ggatctacca agggacagat ccagctggtg     1980

cagtctggcc ccgagctgaa gaaacctggc gagacagtga agatctcctg caaggccagc     2040

ggctacacct tcaccgacta cagcatcaac tgggtcaaga gagcccctgg caagggcctg     2100

aaatggatgg gctggatcaa caccgaaacc agagagcccg cctacgccta cgacttcaga     2160

ggcagattcg ccttcagcct ggaaaccagc gccagcacag cctacctgca gatcaacaac     2220

ctgaagtacg aggacaccgc cacctacttt tgcgccctgg attacagcta cgccatggac     2280

tattggggcc agggcacaag cgtgaccgtg tcctctacaa caacccctgc tcctcggcct     2340

cctacaccag ctcctacaat tgcctctcag cccctgtctc tgaggcccga agcttgtaga     2400

cctgctgctg gcggagccgt gcatacaaga ggactggatt tcgcctgcga catctacatc     2460

tgggcccctc tggctggaac atgtggcgtg ctgctgctga gcctggtcat caccctgtac     2520

tgcaagcggg gcagaaagaa gctgctgtac atcttcaagc agcccttcat gcggcccgtg     2580

cagaccacac aagaggaaga tggctgctcc tgcagattcc ctgaggaaga agaaggcggc     2640

tgcgagctga gagtgaagtt cagcagatcc gccgacgctc ccgcctataa gcagggacag     2700

aatcagctct acaacgagct gaacctgggg cgcagagaag agtacgatgt gctggacaag     2760

cggagaggca gagatcctga gatgggcggc aagcccagac ggaagaatcc tcaagagggc     2820

ctgtacaatg agctgcagaa agacaagatg gccgaggcct acagcgagat cggaatgaag     2880

ggcgaacgca gaagaggcaa gggacacgat ggcctgtatc agggcctgag caccgccaca     2940

aaggacacct atgatgccct gcacatgcag gccctgcctc caagataa                  2988


<210> 46
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser Ser His 
    210                 215                 220                 


His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp His Lys Asp 
225                 230                 235                 240 


Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp Ile Asp Thr 
                245                 250                 255     


His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser Val Ser Tyr 
            260                 265                 270         


Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His Ala Phe Asn 
        275                 280                 285             


Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys Gly Gly Pro 
    290                 295                 300                 


Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His Trp Gly Ser 
305                 310                 315                 320 


Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys Lys Tyr Ala 
                325                 330                 335     


Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly Asp Phe Gly 
            340                 345                 350         


Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly Ile Phe Leu 
        355                 360                 365             


Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val Asp Val Leu 
    370                 375                 380                 


Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr Asn Phe Asp 
385                 390                 395                 400 


Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr Tyr Pro Gly 
                405                 410                 415     


Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp Ile Val Leu 
            420                 425                 430         


Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys Phe Arg Lys 
        435                 440                 445             


Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met Val Asp Asn 
    450                 455                 460                 


Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys Ala Ser Phe 
465                 470                 475                 480 


Lys Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Gly Ser Met Ala Leu Pro Val Thr Ala 
            500                 505                 510         


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile 
        515                 520                 525             


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Met Ser Leu Gly Lys Arg 
    530                 535                 540                 


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Val Ile Gly Ala 
545                 550                 555                 560 


His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
                565                 570                 575     


Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val 
        595                 600                 605             


Glu Glu Asp Asp Val Ala Ile Tyr Ser Cys Leu Gln Ser Arg Ile Phe 
    610                 615                 620                 


Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr 
625                 630                 635                 640 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln 
                645                 650                 655     


Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
            660                 665                 670         


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser 
        675                 680                 685             


Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
    690                 695                 700                 


Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg 
705                 710                 715                 720 


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
                725                 730                 735     


Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            740                 745                 750         


Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
        755                 760                 765             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        835                 840                 845             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    850                 855                 860                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
865                 870                 875                 880 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                885                 890                 895     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            900                 905                 910         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        915                 920                 925             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210> 47
<211> 2988
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660

ggatcctccc atcactgggg gtacggcaaa cacaacggac ctgagcactg gcataaggac      720

ttccccattg ccaagggaga gcgccagtcc cctgttgaca tcgacactca tacagccaag      780

tatgaccctt ccctgaagcc cctgtctgtt tcctatgatc aagcaacttc cctgaggatc      840

ctcaacaatg gtcatgcttt caacgtggag tttgatgact ctcaggacaa agcagtgctc      900

aagggaggac ccctggatgg cacttacaga ttgattcagt ttcactttca ctggggttca      960

cttgatggac aaggttcaga gcatactgtg gataaaaaga aatatgctgc agaacttcac     1020

ttggttcact ggaacaccaa atatggggat tttgggaaag ctgtgcagca acctgatgga     1080

ctggccgttc taggtatttt tttgaaggtt ggcagcgcta aaccgggcct tcagaaagtt     1140

gttgatgtgc tggattccat taaaacaaag ggcaagagtg ctgacttcac taacttcgat     1200

cctcgtggcc tccttcctga atccctggat tactggacct acccaggctc actgaccacc     1260

cctcctcttc tggaatgtgt gacctggatt gtgctcaagg aacccatcag cgtcagcagc     1320

gagcaggtgt tgaaattccg taaacttaac ttcaatgggg agggtgaacc cgaagaactg     1380

atggtggaca actggcgccc agctcagcca ctgaagaaca ggcaaatcaa agcttccttc     1440

aaaggatccg gagctaccaa ttttagtctt ttgaagcaag ccggagacgt cgaagagaac     1500

ccgggtcccg gatctatggc tctgcctgtg acagctctgc tgctgcctct ggctctgctt     1560

ctgcatgccg ccagacctga catcgtgctg acacagtctc cagccagcct ggccatgtct     1620

ctgggaaaga gagccaccat cagctgcaga gcctctgaga gcgtgtccgt gattggagcc     1680

cacctgatcc actggtatca gcagaagcct ggacagcctc ctaagctgct gatctacctg     1740

gccagcaacc tggaaacagg cgtgccagcc agattttctg gcagcggctc tggcaccgac     1800

ttcaccctga caatcgaccc cgtggaagag gacgacgtgg ccatctacag ctgcctgcag     1860

agcagaatct tccccagaac ctttggcgga ggcaccaagc tggaaatcaa gggcagcaca     1920

agcggcagcg gcaaacctgg atctggcgag ggatctacca agggacagat ccagctggtg     1980

cagtctggcc ccgagctgaa gaaacctggc gagacagtga agatctcctg caaggccagc     2040

ggctacacct tcaccgacta cagcatcaac tgggtcaaga gagcccctgg caagggcctg     2100

aaatggatgg gctggatcaa caccgaaacc agagagcccg cctacgccta cgacttcaga     2160

ggcagattcg ccttcagcct ggaaaccagc gccagcacag cctacctgca gatcaacaac     2220

ctgaagtacg aggacaccgc cacctacttt tgcgccctgg attacagcta cgccatggac     2280

tattggggcc agggcacaag cgtgaccgtg tcctctacaa caacccctgc tcctcggcct     2340

cctacaccag ctcctacaat tgcctctcag cccctgtctc tgaggcccga agcttgtaga     2400

cctgctgctg gcggagccgt gcatacaaga ggactggatt tcgcctgcga catctacatc     2460

tgggcccctc tggctggaac atgtggcgtg ctgctgctga gcctggtcat caccctgtac     2520

tgcaagcggg gcagaaagaa gctgctgtac atcttcaagc agcccttcat gcggcccgtg     2580

cagaccacac aagaggaaga tggctgctcc tgcagattcc ctgaggaaga agaaggcggc     2640

tgcgagctga gagtgaagtt cagcagatcc gccgacgctc ccgcctataa gcagggacag     2700

aatcagctct acaacgagct gaacctgggg cgcagagaag agtacgatgt gctggacaag     2760

cggagaggca gagatcctga gatgggcggc aagcccagac ggaagaatcc tcaagagggc     2820

ctgtacaatg agctgcagaa agacaagatg gccgaggcct acagcgagat cggaatgaag     2880

ggcgaacgca gaagaggcaa gggacacgat ggcctgtatc agggcctgag caccgccaca     2940

aaggacacct atgatgccct gcacatgcag gccctgcctc caagataa                  2988


<210> 48
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser Gly Ser Gly Ser Gly Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
145                 150                 155                 160 


Gly Ser Gly Ser Gly Ser Lys Gln Glu His Phe Pro Asp Asn Leu Leu 
                165                 170                 175     


Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile 
            180                 185                 190         


Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg 
        195                 200                 205             


Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val Gly Ser 
    210                 215                 220         


<210> 49
<211> 666
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 49
atggacatgc gggtgcctgc acaacttctg ggcctgctgt tgttgtggct gtctggagcc       60

cggtgtaatt gggtaaatgt tatcagtgat ctcaagaaga tagaggatct catccagtcc      120

atgcatattg atgccacgct gtacacagaa agcgatgtgc atcctagctg taaggtgaca      180

gcgatgaagt gttttctttt ggagctgcag gtaattagtc ttgagtccgg cgatgccagc      240

attcatgata ccgtagaaaa cttgattatc ctggccaaca attctctgtc ctcaaacgga      300

aacgtaaccg agagcggttg taaagaatgt gaagaactgg aagaaaagaa catcaaggag      360

tttctgcaat cattcgttca catcgtacaa atgttcataa atacgtcagg atctggttct      420

ggttccggaa gtggatctgg ttcagggtcc ggtagtggat ctgggtcagg aagtggaagc      480

ggtagtgggt ctggatctaa acaagagcac tttcctgata acctgttgcc gagctgggcg      540

attacgctta tcagtgtaaa cggcatcttt gtaatatgct gtctgaccta ctgcttcgca      600

ccaaggtgcc gggagagaag gagaaatgaa agactgagaa gggagagcgt gagacctgtg      660

ggatcc                                                                 666


<210> 50
<211> 492
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Ile Tyr Ser 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
                485                 490         


<210> 51
<211> 1479
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctgacatcg tgctgacaca gtctccagcc agcctggcca tgtctctggg aaagagagcc      120

accatcagct gcagagcctc tgagagcgtg tccgtgattg gagcccacct gatccactgg      180

tatcagcaga agcctggaca gcctcctaag ctgctgatct acctggccag caacctggaa      240

acaggcgtgc cagccagatt ttctggcagc ggctctggca ccgacttcac cctgacaatc      300

gaccccgtgg aagaggacga cgtggccatc tacagctgcc tgcagagcag aatcttcccc      360

agaacctttg gcggaggcac caagctggaa atcaagggca gcacaagcgg cagcggcaaa      420

cctggatctg gcgagggatc taccaaggga cagatccagc tggtgcagtc tggccccgag      480

ctgaagaaac ctggcgagac agtgaagatc tcctgcaagg ccagcggcta caccttcacc      540

gactacagca tcaactgggt caagagagcc cctggcaagg gcctgaaatg gatgggctgg      600

atcaacaccg aaaccagaga gcccgcctac gcctacgact tcagaggcag attcgccttc      660

agcctggaaa ccagcgccag cacagcctac ctgcagatca acaacctgaa gtacgaggac      720

accgccacct acttttgcgc cctggattac agctacgcca tggactattg gggccagggc      780

acaagcgtga ccgtgtcctc tacaacaacc cctgctcctc ggcctcctac accagctcct      840

acaattgcct ctcagcccct gtctctgagg cccgaagctt gtagacctgc tgctggcgga      900

gccgtgcata caagaggact ggatttcgcc tgcgacatct acatctgggc ccctctggct      960

ggaacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtactgcaa gcggggcaga     1020

aagaagctgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac cacacaagag     1080

gaagatggct gctcctgcag attccctgag gaagaagaag gcggctgcga gctgagagtg     1140

aagttcagca gatccgccga cgctcccgcc tataagcagg gacagaatca gctctacaac     1200

gagctgaacc tggggcgcag agaagagtac gatgtgctgg acaagcggag aggcagagat     1260

cctgagatgg gcggcaagcc cagacggaag aatcctcaag agggcctgta caatgagctg     1320

cagaaagaca agatggccga ggcctacagc gagatcggaa tgaagggcga acgcagaaga     1380

ggcaagggac acgatggcct gtatcagggc ctgagcaccg ccacaaagga cacctatgat     1440

gccctgcaca tgcaggccct gcctccaaga ggatcctaa                            1479


<210> 52
<211> 7733
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc       60

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat      120

taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt      180

aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt      240

atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat      300

tacgccaagc gcgcaattaa ccctcactaa agggaacaaa agctggagct gcaagcttaa      360

tgtagtctta tgcaatactc ttgtagtctt gcaacatggt aacgatgagt tagcaacatg      420

ccttacaagg agagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtacgatc      480

gtgccttatt aggaaggcaa cagacgggtc tgacatggat tggacgaacc actgaattgc      540

cgcattgcag agatattgta tttaagtgcc tagctcgata caataaacgg gtctctctgg      600

ttagaccaga tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct      660

caataaagct tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt      720

aactagagat ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga      780

acagggacct gaaagcgaaa gggaaaccag agctctctcg acgcaggact cggcttgctg      840

aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta      900

gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta      960

gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac     1020

atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa     1080

catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag     1140

aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag     1200

agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga     1260

ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat     1320

tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc     1380

accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg     1440

ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat gacgctgacg     1500

gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct     1560

attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca     1620

agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc     1680

tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct     1740

ctggaacaga ttggaatcac acgacctgga tggagtggga cagagaaatt aacaattaca     1800

caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag aatgaacaag     1860

aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata acaaattggc     1920

tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta agaatagttt     1980

ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta tcgtttcaga     2040

cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa gaaggtggag     2100

agagagacag agacagatcc attcgattag tgaacggatc tcgacggtat cgattagact     2160

gtagcccagg aatatggcag ctagattgta cacatttaga aggaaaagtt atcttggtag     2220

cagttcatgt agccagtgga tatatagaag cagaagtaat tccagcagag acagggcaag     2280

aaacagcata cttcctctta aaattagcag gaagatggcc agtaaaaaca gtacatacag     2340

acaatggcag caatttcacc agtactacag ttaaggccgc ctgttggtgg gcggggatca     2400

agcaggaatt tggcattccc tacaatcccc aaagtcaagg agtaatagaa tctatgaata     2460

aagaattaaa gaaaattata ggacaggtaa gagatcaggc tgaacatctt aagacagcag     2520

tacaaatggc agtattcatc cacaatttta aaagaaaagg ggggattggg gggtacagtg     2580

caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa ttacaaaaac     2640

aaattacaaa aattcaaaat tttcgggttt attacaggga cagcagagat ccagtttggc     2700

tgcatacgcg tcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt     2760

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg     2820

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga     2880

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag     2940

aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc     3000

ttgcgtgcct tgaattactt ccacctggct gcagtacgtg attcttgatc ccgagcttcg     3060

ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa ggagcccctt cgcctcgtgc     3120

ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt ggcaccttcg     3180

cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat gacctgctgc     3240

gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caagatctgc acactggtat     3300

ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca catgttcggc     3360

gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg     3420

gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct     3480

ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctgcagg     3540

gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag     3600

gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccactgagt accgggcgcc     3660

gtccaggcac ctcgattagt tctcgtgctt ttggagtacg tcgtctttag gttgggggga     3720

ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc     3780

ttggcacttg atgtaattct ccttggaatt tgcccttttt gagtttggat cttggttcat     3840

tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgagctag     3900

actagtgata tcggatcccg ggacgtggtc gacgctagca atcaacctct ggattacaaa     3960

atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac     4020

gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc     4080

ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt     4140

ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc     4200

tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc     4260

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     4320

gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg cctgtgttgc cacctggatt     4380

ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc     4440

cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt     4500

cggatctccc tttgggccgc ctccccgcct ggaattcgag ctcggtacct ttaagaccaa     4560

tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag     4620

ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg tctctctggt     4680

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     4740

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     4800

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt agtagttcat     4860

gtcatcttat tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga     4920

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     4980

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt     5040

atcatgtctg gctctagcta tcccgcccct aactccgccc agttccgccc attctccgcc     5100

ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct     5160

attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcgtcg agacgtaccc     5220

aattcgccct atagtgagtc gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt     5280

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc     5340

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg     5400

aatggcgaat ggcgcgacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     5460

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     5520

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     5580

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     5640

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     5700

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     5760

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     5820

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttcccaggtg     5880

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     5940

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     6000

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     6060

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     6120

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     6180

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     6240

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     6300

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     6360

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     6420

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     6480

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     6540

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     6600

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     6660

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     6720

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     6780

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     6840

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     6900

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     6960

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     7020

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     7080

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     7140

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt     7200

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     7260

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     7320

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     7380

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     7440

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     7500

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     7560

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     7620

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     7680

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcc            7733
