                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Generation of a high producing recombinant Chinese hamster ovary 
       cell line for therapeutic protein production

<130>  BEX 21P1358

<150>  EP20306068.6
<151>  2020-09-21

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  1188
<212>  DNA
<213>  Cricetulus griseus

<400>  1
atggcttggc ggcagatgcg gaagagagcc ctggacgccg ctatcatcct gggaggcgga       60

ggcctgctgt tcacctctta cctgacagcc accggcgacg accacttcta cgccgagtac      120

ctgatgcctg ccctgcagag actgctggac cctgagtctg cccaccggct ggccatcaga      180

ttcacctccc tgggcctgct gcccagagcc accttccagg actccgacat gctggaagtg      240

cgggtgctgg gccacaagtt cagaaacccc gtgggaatcg ccgctggctt cgacaagcac      300

ggcgaggctg tggacggcct gtacaagctg ggcttcggct tcgtggaagt gggctccgtg      360

acaccccagc cccaggaagg caaccccaga cctagagtgt tccggctgcc tgaggaccag      420

gccgtgatca acagatacgg cttcaactcc cacggcctgt ccgtggtgga acaccggctg      480

agagccagac agcagaagca gaacaagctg accgccgacg gcctgcccct gggcatcaat      540

ctgggcaaga acaagacctc cgaggacgct gccgccgact acgtggaagg cgtgcgagtg      600

ctgggacctc tggccgatta cctggtcgtg aacgtgtcct cccccaacac cgctggcctg      660

agaagcctgc agggaaaggc cgagctgaga aggctgctgg ccaaggtgct gcaggaacgg      720

gacgctctga agggcgccca gaaacctgcc gtgctcgtga agatcgcccc tgacctgacc      780

gcccaggaca aagaggatat cgcctccgtg gccagagagc tgggcatcga cggactgatc      840

gtgaccaaca ccaccgtgtc tcggcctacc ggactgcagg gcgctctgag atctgagatg      900

ggcggcctgt ctggcaagcc tctgagggac ctgtccaccc agaccatcag agagatgtac      960

accctgaccc agggccggat ccccatcatt ggagtgggcg gagtgtcctc tggccaggac     1020

gccctggaaa agatccaggc tggcgcctct ctggtgcagc tgtataccgc cctgaccttt     1080

ctgggccctc ccgtggtggt gcgagtgaag agagaactgg aagccctgct gaaagagcgg     1140

ggcttcaaca ccgtgaccga ggccatcggc gctgaccaca gaagatga                  1188


<210>  2
<211>  395
<212>  PRT
<213>  Cricetulus griseus

<400>  2

Met Ala Trp Arg Gln Met Arg Lys Arg Ala Leu Asp Ala Ala Ile Ile 
1               5                   10                  15      


Leu Gly Gly Gly Gly Leu Leu Phe Thr Ser Tyr Leu Thr Ala Thr Gly 
            20                  25                  30          


Asp Asp His Phe Tyr Ala Glu Tyr Leu Met Pro Ala Leu Gln Arg Leu 
        35                  40                  45              


Leu Asp Pro Glu Ser Ala His Arg Leu Ala Ile Arg Phe Thr Ser Leu 
    50                  55                  60                  


Gly Leu Leu Pro Arg Ala Thr Phe Gln Asp Ser Asp Met Leu Glu Val 
65                  70                  75                  80  


Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly 
                85                  90                  95      


Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Leu Gly Phe 
            100                 105                 110         


Gly Phe Val Glu Val Gly Ser Val Thr Pro Gln Pro Gln Glu Gly Asn 
        115                 120                 125             


Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn 
    130                 135                 140                 


Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg Leu 
145                 150                 155                 160 


Arg Ala Arg Gln Gln Lys Gln Asn Lys Leu Thr Ala Asp Gly Leu Pro 
                165                 170                 175     


Leu Gly Ile Asn Leu Gly Lys Asn Lys Thr Ser Glu Asp Ala Ala Ala 
            180                 185                 190         


Asp Tyr Val Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu 
        195                 200                 205             


Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln 
    210                 215                 220                 


Gly Lys Ala Glu Leu Arg Arg Leu Leu Ala Lys Val Leu Gln Glu Arg 
225                 230                 235                 240 


Asp Ala Leu Lys Gly Ala Gln Lys Pro Ala Val Leu Val Lys Ile Ala 
                245                 250                 255     


Pro Asp Leu Thr Ala Gln Asp Lys Glu Asp Ile Ala Ser Val Ala Arg 
            260                 265                 270         


Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg 
        275                 280                 285             


Pro Thr Gly Leu Gln Gly Ala Leu Arg Ser Glu Met Gly Gly Leu Ser 
    290                 295                 300                 


Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr 
305                 310                 315                 320 


Thr Leu Thr Gln Gly Arg Ile Pro Ile Ile Gly Val Gly Gly Val Ser 
                325                 330                 335     


Ser Gly Gln Asp Ala Leu Glu Lys Ile Gln Ala Gly Ala Ser Leu Val 
            340                 345                 350         


Gln Leu Tyr Thr Ala Leu Thr Phe Leu Gly Pro Pro Val Val Val Arg 
        355                 360                 365             


Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Arg Gly Phe Asn Thr 
    370                 375                 380                 


Val Thr Glu Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395 


<210>  3
<211>  1188
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcttggc ggcacctgaa gaagagggcc caggacgccg tgatcatcct gggaggcgga       60

ggcctgctgt tcgcctctta cctgatggct accggcgacg agcggttcta cgccgagcat      120

ctgatgccca cactgcaggg cctgctggac cctgagtctg cccatagact ggccgtgcgg      180

ttcacctccc tgggactgct gcctagagcc cggttccagg actccgacat gctggaagtg      240

cgggtgctgg gccacaagtt cagaaacccc gtgggaatcg ccgctggctt cgacaagcac      300

ggcgaggctg tggacggcct gtacaagatg ggcttcggct tcgtggaaat cggctccgtg      360

acccccaagc cccaggaagg caaccccaga cctcgggtgt tcagactgcc tgaggaccag      420

gctgtgatca acagatacgg cttcaactcc cacggcctgt ccgtggtgga acaccggctg      480

agagccagac agcagaagca ggccaagctg accgaggatg gcctgcctct gggagtgaac      540

ctgggcaaga acaagacctc cgtggacgcc gccgaggatt acgctgaagg cgtgcgagtg      600

ctgggacccc tggctgatta cctggtcgtg aacgtgtcct cccccaacac cgctggcctg      660

agatctctgc agggcaaggc cgagctgcgg agactgctga caaaggtgct gcaggaacgc      720

gacggcctgc ggagagtgca tagacctgcc gtgctcgtga agatcgcccc cgacctgacc      780

agccaggaca aagaggatat cgcctccgtc gtgaaagagc tgggcatcga cggactgatc      840

gtgaccaaca ccaccgtgtc taggcctgcc ggactgcagg gggctctgag atctgaaacc      900

ggcggactgt ccggcaagcc tctgagggat ctgtccaccc agaccatcag agagatgtac      960

gccctgaccc agggccgggt gccaatcatt ggagtgggcg gagtgtcctc cggccaggat     1020

gccctggaaa agatcagagc cggcgcttcc ctggtgcagc tgtacaccgc tctgaccttt     1080

tggggccctc ccgtcgtggg caaagtgaag agagagctgg aagccctgct gaaagagcag     1140

ggatttggcg gcgtgaccga tgccatcggc gctgaccaca gaagatga                  1188


<210>  4
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Trp Arg His Leu Lys Lys Arg Ala Gln Asp Ala Val Ile Ile 
1               5                   10                  15      


Leu Gly Gly Gly Gly Leu Leu Phe Ala Ser Tyr Leu Met Ala Thr Gly 
            20                  25                  30          


Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly Leu 
        35                  40                  45              


Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser Leu 
    50                  55                  60                  


Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Glu Val 
65                  70                  75                  80  


Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly 
                85                  90                  95      


Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Met Gly Phe 
            100                 105                 110         


Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys Pro Gln Glu Gly Asn 
        115                 120                 125             


Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn 
    130                 135                 140                 


Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg Leu 
145                 150                 155                 160 


Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu Pro 
                165                 170                 175     


Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu 
            180                 185                 190         


Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu 
        195                 200                 205             


Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln 
    210                 215                 220                 


Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Leu Gln Glu Arg 
225                 230                 235                 240 


Asp Gly Leu Arg Arg Val His Arg Pro Ala Val Leu Val Lys Ile Ala 
                245                 250                 255     


Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile Ala Ser Val Val Lys 
            260                 265                 270         


Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg 
        275                 280                 285             


Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu Ser 
    290                 295                 300                 


Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr 
305                 310                 315                 320 


Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly Val Gly Gly Val Ser 
                325                 330                 335     


Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu Val 
            340                 345                 350         


Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro Pro Val Val Gly Lys 
        355                 360                 365             


Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly Gly 
    370                 375                 380                 


Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395 


<210>  5
<211>  1122
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaccacct ccgcctccag ccacctgaac aagggcatca aacaggtgta catgagcctg       60

ccccagggcg agaaggtgca ggccatgtac atctggatcg acggcaccgg cgagggactg      120

cggtgcaaga ccagaaccct ggactccgag cctaagtgcg tggaagaact gcccgagtgg      180

aacttcgacg gctcctccac cctgcagtcc gagggctcca actccgacat gtacctggtg      240

cctgccgcca tgttccggga ccctttccgg aaggacccca acaagctggt gctgtgcgag      300

gtgttcaagt acaacagacg gcctgccgag acaaacctgc ggcatacctg caagcggatc      360

atggacatgg tgtccaacca gcacccttgg tttggcatgg aacaggagta caccctgatg      420

ggcaccgacg gccacccctt cggctggcct tctaacggct tccctggccc ccagggcccc      480

tactattgtg gcgtgggcgc cgaccgggcc tacggcagag atatcgtgga agcccactac      540

cgggcctgcc tgtacgccgg agtgaagatc gccggcacca acgccgaagt gatgcccgcc      600

cagtgggagt tccagatcgg cccttgcgag ggcatctcca tgggcgatca cctgtgggtg      660

gcccggttca tcctgcacag agtgtgcgag gacttcggcg tgatcgccac cttcgacccc      720

aagcccatcc ccggcaactg gaacggcgct ggctgccaca ccaacttctc caccaaggcc      780

atgcgggaag agaacggcct gaagtacatc gaggaagcca tcgagaagct gtccaagcgg      840

caccagtacc acatcagagc ctacgaccct aagggcggcc tggacaacgc cagaaggctg      900

accggctttc acgagacatc caacatcaac gacttctctg ccggcgtggc caacagatcc      960

gcctccatcc ggatccctag aaccgtgggc caggaaaaga agggctactt cgaggacaga     1020

cggccctccg ccaactgcga cccctttagc gtgaccgagg ccctgatccg gacctgcctg     1080

ctgaacgaga caggcgacga gcccttccag tacaagaact ga                        1122


<210>  6
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  7
<211>  1122
<212>  DNA
<213>  Canis lupus

<400>  7
atggccacct ccgcctccag ccacctgaac aagggcatca aacaggtgta catgagcctg       60

ccccagggcg agaaggtgca ggccatgtac atctggatcg acggcaccgg cgagggactg      120

cggtgcaaga ccagaaccct ggactccgag cccaagggcg tggaagaact gcccgagtgg      180

aacttcgacg gctcctccac cttccagtcc gagggctcca actccgacat gtacctggtg      240

cctgccgcca tgttccggga ccctttccgg aaggacccca acaagctggt gttctgcgag      300

gtgttcaagt acaaccggaa gcccgccgag acaaacctgc ggcatacctg caagcggatc      360

atggacatgg tgtccaacca gcacccttgg tttggcatgg aacaggagta caccctgatg      420

ggcaccgacg gccacccctt cggctggcct tctaacggct tccctggccc ccagggcccc      480

tactattgtg gcgtgggcgc cgacaaggcc tacggcagag acatcgtgga agcccactac      540

cgggcctgcc tgtacgccgg catcaagatc gctggcacca acgccgaagt gatgcccgcc      600

cagtgggagt tccagatcgg cccttgcgag ggcatcgaca tgggcgatca cctgtgggtg      660

gcccggttca tcctgcacag agtgtgcgag gacttcggcg tgatcgccac cttcgacccc      720

aagcccatcc ccggcaactg gaacggcgct ggctgccaca ccaacttctc caccaaggcc      780

atgcgggaag agaacggcct gaagtacatc gaggaatcca tcgagaagct gtccaagcgg      840

caccagtacc acatccgggc ctacgacccc aagggcggcc tggataacgc cagacggctg      900

accggcttcc acgagacatc caacatcaac gacttctctg ccggcgtggc caacagaggc      960

gcctccatcc ggatcccccg gaccgtgggc caggaaaaga agggctactt cgaggacaga     1020

cggccctccg ccaactgcga cccctttagc gtgaccgagg ccctgatccg gacctgcctg     1080

ctgaacgaga caggcgacga gcccttccag tacaagaact ga                        1122


<210>  8
<211>  373
<212>  PRT
<213>  Canis lupus

<400>  8

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Gly Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Phe Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Phe Cys Glu Val Phe Lys Tyr Asn Arg Lys Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Ile Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Asp Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ser Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Gly 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  9
<211>  373
<212>  PRT
<213>  Cricetulus griseus

<400>  9

Met Ala Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Met 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Val Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Cys Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Phe Gln Ser Glu Ser Ser Asn Ser Asp Met Tyr Leu Ser 
65                  70                  75                  80  


Pro Val Ala Met Phe Arg Asp Pro Phe Arg Lys Glu Pro Asn Lys Leu 
                85                  90                  95      


Val Phe Cys Glu Val Phe Lys Tyr Asn Gln Lys Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Leu Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asp Gly Phe Pro Gly Pro Gln Gly Leu 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Lys Ala Tyr Arg Arg Asp Ile Met 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Thr Gly 
            180                 185                 190         


Thr Tyr Ala Glu Val Lys His Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Arg Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Lys Asp Phe Gly Val Ile Ala Thr Phe Asp Ser 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Thr Met Arg Glu Glu Asn Gly Leu Lys His Ile Lys Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Arg Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Lys Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asp Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Ala Arg Cys Pro Ser Ala Asn Cys Asp Pro Phe Ala Val Thr 
            340                 345                 350         


Glu Ala Ile Val Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Gln Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  corresponding piece of DNA for generating DHODH gRNA

<400>  10
ggatgcagcc atcatccttg                                                   20


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence1')

<400>  11
ggatgcagcc atcatccttg gtttt                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence1')

<400>  12
caaggatgat ggctgcatcc cggtg                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining  DHODH gRNA (Sequence2')

<400>  13
gatgcagcca tcatccttgg gtttt                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence2')

<400>  14
ccaaggatga tggctgcatc cggtg                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence3')

<400>  15
gcagccatca tccttggggg gtttt                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence3')

<400>  16
cccccaagga tgatggctgc cggtg                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining  DHODH gRNA (Sequence4')

<400>  17
gccatcatcc ttgggggagg gtttt                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence4')

<400>  18
cctcccccaa ggatgatggc cggtg                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence5')

<400>  19
gctattcgct tcacgtccct gtttt                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence5')

<400>  20
agggacgtga agcgaatagc cggtg                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence6')

<400>  21
gcctctacaa actgggcttt gtttt                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence6')

<400>  22
aaagcccagt ttgtagaggc cggtg                                             25


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence7')

<400>  23
ggctttgggt ttgtcgaggt gtttt                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence7')

<400>  24
acctcgacaa acccaaagcc cggtg                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence8')

<400>  25
gctggtctga ggagcctaca gtttt                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide used for obtaining DHODH gRNA (Sequence8')

<400>  26
tgtaggctcc tcagaccagc cggtg                                             25


<210>  27
<211>  14437
<212>  DNA
<213>  Cricetulus griseus


<220>
<221>  misc_feature
<222>  (1992)..(2015)
<223>  target of plasmids pBH6840 KO DHODH SEQ1 and pBH6841 KO DHODH 
       SEQ4

<220>
<221>  misc_feature
<222>  (2129)..(2147)
<223>  target of plasmids pBH6842 KO DHODH SEQ5

<220>
<221>  misc_feature
<222>  (4015)..(4047)
<223>  target of plasmids pBH6843 KO DHODH SEQ7

<400>  27
ccgagcccac attctccaat ggagtggagg cagaggcggg cccagtggca gaaggagcat       60

ggcgtggaga cagatgagag tgagtctgtt gcgggtgctt acgcttgttc ggaaaacagg      120

ttgggagtgg acgaggctgg gagattgaaa ggctggggcc cttgcagtgt gggctgcatg      180

tgtgctcagc taggggcatg caaaaagcaa gcgtgctggg cagaggctga gttgattgtg      240

agagatcgcg ggcttttttt tttttttttt tcttaaactg agctagtatc gggcccctgt      300

gagcacatgg tggctagcat tatggaaagg atccagggcg gaatgaaata agacacgcag      360

ccacccttcc agataaagtg tggttagaat gggagtcccg tgcgaagagt ccgtagattg      420

tgtccctggc ttgggaaaga gtgcgcagat attgtttctt gacacgtgag aatttctccc      480

tccagaggag ggagaatgaa tacttggttt gctgtacagg caaatctgat cacatcctct      540

acttccttat ttagtggaca aatcccatta aaaatataat cactgattgt ggtgaggggt      600

tgtgctgtga catgggagct ggaaccgaac tctgcactta accactgaac catctccagc      660

ccccaaatct gtattttggc tgacaccccc acatttctcc taccttactt taagaaatgc      720

tttcctttta gttccaaaca gacctgtctt cctctacccc attctctggc ccttctcatt      780

ggcttcagcc acctagagat tccttctcca gctgcttcct cctctttagc ttttgtgtct      840

ccttggaaag tcaaccttag cctggaagga gcctcaagat ccttccatta cttatctctt      900

cgtgtcagtt ttcttgggtt tgtgtttaca tggccattaa tttctctctt cattagatag      960

attacacact tctgaaggac agggacctgg tgtggtttgc ttgcctttgg tgaaggattg     1020

aatgaatgca ttagccactt ggcatctggc agtgataatt atcaaaaagc attgtgagcc     1080

tcctttgaac tagggtagtg attctctacc cagagtgtga agctatgttt gtattacaac     1140

cacttttata ttatacacat aggacatttc aggccagtaa cttttctagg tataatttta     1200

aaatatagac accatgtcct aactacagta taaaggagaa atgaaaacat gtatttcagt     1260

atgtagaagt cagaacacag ttcacctaca tagatggcca ggtgtttaag cctctattta     1320

gaaggtgtgc gttggtatac aaacagcact gtataccctt tctggtgggg ttttaggaac     1380

agtgaccaag tcttagtaat gttttgtgca aactgtacaa ttgtccttaa attacaaggt     1440

atctttattt ctgtaaaagt caccctgtac atgtaaacca tgtggttgtg tggtgaacta     1500

tagcttgctt cttgcctctc ctattatcct cagataatag gaagttttcc tcacataaat     1560

agcaatagca agttcaaaca tcatacagta catagggaaa ctagtgtgtt agctttaatt     1620

aaagaagaat attgacagga ctgatttctc cacaccaaat gtattagcat cattccctca     1680

ttaactagta aaaattttcc catgtgaccc ctagggggca gtactgcctg tcttgaaaat     1740

tccctgcctg gtccttagga aaatattcag ggctagaacc catgtaagca gtgtaggtac     1800

tgcatctacc tttgtagatg tgtaagtggg caggatatga agggggacag tgtgagcagg     1860

gaaggactgt cactttgtgt agttgttatg tcctctgggc aggtgtgaag ggtcaggaag     1920

ggtactgcag gctggtctga tggggttccc catggggcct tttctctccc ccactagaag     1980

cgggccctgg atgcagccat catccttggg ggaggaggac ttctcttcac ctcttacctg     2040

acagccacgg gcgatgacca tttctatgct gaatatctga tgccggccct gcagaggctg     2100

ctagacccag aatcagccca ccggctagct attcgcttca cgtccctggg gctccttcct     2160

cgagctacat ttcaggactc tgacatgctg gtaggtcccc cggtcaccct gtgttacatt     2220

tgtgtttgta ggggaggtca catccttcag cacttcggta ttcctctgct gccactgggc     2280

ttttgaaaac cagagctgca ggttcacaag cagctgggac ctggagccca gcccgaggaa     2340

gggacttttc ttctgtgtta caccctgtac ttacagaaca gcactcagca tatagccggt     2400

gcttacagct ttaatcctca cagataccct ttgagggagg tcctatctca tctccatcta     2460

caaatcagga aactgaggta cagactaagt aagtgacttg cccaaggtca cacagctggg     2520

aggtggcagg accaggattc aaacctatag agtttgactc cagtgtccaa ccttggtcac     2580

tggcctgcct tgctgagatc cctctgctga acaggaacat cttctggagt cattaagcag     2640

ctactggatg caggggacag ggtcagcagg gaagggctgt cacttgtaga tactgtgtcc     2700

tctgtctgga taggtgtgaa gtctcagagt gggtgctgca gcctggcctg atgggtccgt     2760

cctttccccc catcagaagc agaccctggc tgtagtcatc accctgaggg gtggaggact     2820

taagtcctag gcaacctcct gccccagcca cattcagcca caactcactc ctgtggccca     2880

cctggcacca tttataacag agccagtgtg gcccttctac tgtctctctg aatgctcccc     2940

ttttgagatg ggcctaggtt gtccaggttg gtctcaaact tggggtccca aatgatttca     3000

gaatctcagc ttcctgagta agtgggatca cacagtatgc accactgtgc gcagtggtcc     3060

ctgttccccg atagccaggc cggttgatac tcttagcccg attcaccttt ctcggttttc     3120

taagtcttca gttttctatc atgacgagac tctcctgggg gagggggatg gctgggtgct     3180

tctggaatgc ttggctgacc cggtctcctg attgaccggt tttaccataa tctcaaagaa     3240

gcctgacatc aacaccccag gctctgtcac acagccaggg atgagaactg gcttgagggt     3300

agcctcaagg aaggcctgtt ctagctgaac ttctcgcctc atggttatga agtgctgcgt     3360

gcacattttt accttccttg tgctcattct cgtctcctgt ggattttgag agcatgtagc     3420

tttccccttg gggactggcc tctaagagct cactggcagc accattgcct gccagtgtcc     3480

acccttcagc tctccatggt gcccatgggc tggcttcttg acagttatgg aggaagggcc     3540

agctagggct tgtatgctag gctggctaca ggctacctca aggctggtga caccaaggac     3600

tccttctcct gcccaggttg agtagatagg aagatacaca gtaattgtgc aagacagcac     3660

ctgtctcctc ttcacttgtg gtgggacact atctttctct ccccactgcc ttgagacccc     3720

ctggtgacag actccagcag acatcagaag cacctgcaga atgctgatgc agatagatac     3780

cccagggtgt ccttcctccc aaagatccct attttctggg cccagtgatg cttagcaagc     3840

tccaggggaa ttcttataca gtatgctggg atccctgctg tgagaaccac ttggtatagc     3900

tgcttatacc tctgacctgt ctccttccca ggaagtgaga gtcctgggcc ataaattccg     3960

aaatccggta gggattgctg cgggatttga caagcacggg gaagctgtag atggcctcta     4020

caaactgggc tttgggtttg tcgaggtagg aagtgtgact ccccagcctc aggaaggaaa     4080

ccccagaccc agagtgttcc gcctcccgga ggaccaagct gtcattaaca ggtaggtggt     4140

ggctcaatgt catagggaca tctcctcccc tgctgggatc tctgagatgg aacctgtttt     4200

gtgcttttct catatgatca gtggacagtc tgtcctttgg gatagtcagg agcacctttg     4260

aacacctgtt gtgtactagg cagctctcgc cccaaccttg ggaaacagct gttaggattt     4320

taccaggtat tcccactgag gctctgagag ctggtgctgg ttgcaaagaa cagcttggga     4380

aggcttgggc tgttgggctt cagtgtgagc ttttttacat tgttgctcta ttgcctttgt     4440

ccaatgttgg ctaacaggaa tataatgatc tcacatgtaa tttgaaatat tctaatgatg     4500

cattaaaaac tagtgaactt gataatacat ttataattat tatattttta attattatga     4560

tttaattata aacagtgtgt tctaaagtca ttttaacctg cagtcaatgt aaaaatcatt     4620

ggttaactat cgtcctcttt ttattggttt ccggtccccc aatgccttta cttctggttc     4680

ctctcacttg gccagggctg gtggccacaa gcttcagcag cgttggtact gtacaggtga     4740

cccttgcttt caatgaacag ggacatggta ttcaaatgta cagctgctct taggaggaga     4800

atccttcgac tgtatgaagc cttgcggttt gttgttctgt atagttagta taactgcaaa     4860

gggaagacct tcgtactttt tgctaggaga tttttggaga acctccttgt ggggattttg     4920

gcaggcctgt ggcagtgctt cctactgctt gtttcaggaa actgatttac aagtcataga     4980

tctttctgtt acattacagg cagggactga tgtctttagg actggccaga caaaatactt     5040

gtgtttctga tttggctgtt acaagtgact tcgggtctta ggatgatggt acttgggaca     5100

gggagtggtg agggacaggc acctgtgctc ttgggcatgt gcgaacttag ccttcttgct     5160

catatacaca gtgtgtgttc agtataggca tgctaacgga tgggtattta cacctgcaga     5220

cccacatgcc acaatccatg cagtgttgct ctggctgcaa gcaacaaagt gatgtaacca     5280

gatctcattt gttatcattc ttgtcactag cacaaaataa ctgacagcag gcagcttaag     5340

gaatggggtc aggtattttg gctcacagtt tgaggggaca cgccctcccg gtggcaggag     5400

cctgaggcag agggtcactc tgtacctaca gtgaggaagc agcaagggaa ggatgctggt     5460

gcttgggtct ctttctccgt cttgctcagc tggggtgtga atccatggtg ctgcccatgt     5520

ttgcggtggg tcttccctgc tccattcaac cttcccagaa acagtcttcc agacacacaa     5580

caggtgtgtt tccatggtga ctctaagtca catctagttg acaatgaagc ataaccagtg     5640

gtgagagcat ggaaatggtc tcaggtacgt tttccaaact gccacctttt aattccaccc     5700

cttacctgtg ggtttatgtg ctccaggtac ggattcaaca gccacgggct ctcagtggtg     5760

gaacacaggc tacgggccag acagcagaag cagaacaagc tcactgcagg taaactcagg     5820

tgttgtggga gggacttact aactctatta caaagaaaca tggggagggc atgggattca     5880

gcaataagaa acaaatgagc aaacaattaa aaccccacag aacaactcag gggattgtcc     5940

agcttctacc acagcctcaa aggtctcaac cagatggcat aattcagcaa aaccttgctg     6000

gtctctggca tccatggaac ctgaattgtg tcttaactta ggggcttgaa gatcagcaga     6060

gagcatgtgt ggagctaaga tgcgccccga gttcatcttc ccacatcccg ccctgctgct     6120

gtccttctgt tcactgtgta aatagtgtgt attagttctg gaagagctac agaagagaat     6180

agagttgtca cactcctgtc cttccactca ggggaccagc tgtcctcaaa tctcacttcg     6240

gaaacaacct ttgcttttgg tggattctca tggagacgct ccagtttgtc ctctgtggtc     6300

tgcatggctc tctgaagtgc attttggggt caaagccctg ggtggtggcc cccctcccca     6360

tgtctccctg tgtggcttct gcagtccatg gagatttttc tcctttgcct ctggaatgtc     6420

tttcaggagg tcttagtctc atttgatgtc cccatagtgt gacaattaag ccaaggactt     6480

ctgcatttat ttgaggagct aaggaagaga gggctgaagc atttgacgag tttagagggt     6540

gggaacagga aatgacaatg tttaaaaaaa cccctggttt tgacggaacc gggtctgcca     6600

gccctgtaga accttgaaca caatgtttgt ggtttgtggc gttctcctgc ctcctgcctt     6660

ccgtttcttc gttttaatgc cttctgtggg ctaggtttat tgccattgtc ctgtgtccac     6720

ccttcatcct cattctgtgc cctcacagtc actggagtga ggccaagttc tgtgtctttg     6780

ccctgcctac atgtgtctgc tgacagctag cagcctcata gaaacttttc atcagcacca     6840

tgcctaggaa ccctagtgga tagaagagac tgtgctttgt gtaaagtgta gttcagcctt     6900

cctgactcca gaactgtgac tgtgggcagg tgaccactaa tgaaaggctc agttgcctct     6960

tggaagccat actctcaatc cagtttactt gtgctaaagc ttacagtgat cctggcttgc     7020

tgggtgctag acttgaagct ttgagacctt gttctgtata tagtctaatc cctggctcca     7080

cccagcccac ttaggaaatt agttacacaa atcttacttt taagttgatg acccagaaga     7140

tgacgggttg tgagagatgg actgtgagaa gggggctagc aatacagtgg gggatgttgc     7200

ccgtgtcctc cctggcctgg tatgggtgag ctgacttggt gttctaggtc tggctggatt     7260

ggcagatgga cagcagcctg ggccactgac atactaggag ttgtaagaaa gttgagttgt     7320

aataaagatg aatccaggaa actcctttct gccaaagaga acatgagtct gaaagagcat     7380

ttttctagag gcttggcctt ttgagagtga cagggggcag gtgtgagtaa ttacacccag     7440

gccccaggag tgtcttgagg ctacagagat gtatcatcac cctaattata agttcttttc     7500

tcagagaaca agaaagattt attacacact tccatctact ttttaggcat gatagttgaa     7560

aacatttcct agtgttttcc tgtgtagctc aggctggcct cagacttaca gcaatcctcc     7620

tgcagactaa atttccatgt gtggcctcca gtgttttata cttttgtttt taatcatttc     7680

acatacagtc ccttgaccaa ggctcatgag attcaggttg ttcttgctga catgcccatc     7740

aatacctgcc tactctctct tttgttatct ctcaaaccac tgatctgtga atatagcaag     7800

tgtcattggg agtcatttta ttgctacata cttcaagaag agcagtagta tttgtttttt     7860

tccccatgtc cctgatttgt ctggactcag atccttggcc acccatgcag tcagtgttgg     7920

ggatgggttc catctcatgg attgggcctt aaatacaatc agattctggt tggttactcc     7980

cgcagctttg tgctactgtt tcactagtgc atccagggca ggtcatcatt gtagatcaaa     8040

agatgtgtag cggggttggt gtttaccttt ctcctttggt aacatgcaga atacctccca     8100

gtaccatgga caccaccaga gggatgaagg ctgtaggtag gcaccagctc gacttctccc     8160

tatttaataa cttgtgtagg tgttgtcttt agcaatagag ccttgtcagt tttcagagag     8220

caaccaatat ccttgacaat agcctgggtt gtttgggtat tctcatgggg cccctttggc     8280

caacaacttc tttgaaagtc tggtcaaatt cttcactaaa accatctggc actgggcatt     8340

ttttggttgg gaggctttta tgactgcttc tattttacta ggggttataa gtttgtttac     8400

attgcttatc cgatcttgat ttaactttag tagatggtat gtatcaagaa aattattcat     8460

ttattttcaa ttttccattt aggtagagta taggttttta aaacacatcc ctatgattct     8520

ttggatttcc ttggtgtctg ttgttatgtc actcttttca tctctaattt tgttaatttg     8580

gatctttcct ctttgccttt taattaattt ggctaagggt ttgtcaatct tactggtttt     8640

ctcaaagaac caactcttcg tttcattgat tctttgcatt atttttgtct gtttctattt     8700

cattgatttc agccctgagt ttgattattt cctgccatct actcctcctg ggtgtgactt     8760

cttgttgttc tagagctttc aggtgtgcta gtatgaaatc tctctaattt atgtaggcac     8820

ttagtgctac ataaagtttt gggtttttgt tttgttttga cctatttttc attcagtagt     8880

gagttgttca gtttcagttg ttcagtttcc atgagtttgt aagctttctg ttgtttttgt     8940

aggtgttgat attcagcttt aatctgtggt ggtatgatag ggtattattt cagttttctt     9000

gtatcttttg agacttgctt tatggcctag tatatggtca gttttggaga aagttccatg     9060

aggtgctgag aagaaacgtt ttgtgtttgg gtgaaatgtt ctataaatta ggtccatttg     9120

gtttaacaca tcatttagct ccatcatttc tttgttcagt ttttgtctgg atgacctgtc     9180

tattgtcgag agttggggag tatcaaagta tcccactatg tgtgtgtgtg tgcggagggg     9240

tcaatatgtg atttaagcta tagtagagtt tcttttatga acttggatgc ctttgtgctt     9300

ggtgcataga tgtttagaat ttcaatatcc tcttggtggg tttttccttt gatgagtatg     9360

tagtttcctt ccctatctat ctcttgatta gatttgattt gaaatctatt ctgtcatata     9420

ttaaaatggc ttcacccatt tgctttcttg tccatttgct tggaatatct ttttccatcc     9480

ttttactctg aggtgatatc tatccttgat gttaaagtat gtttcttgga ttcagttaaa     9540

gaatgaatcc tatttttgaa cccaattttt tagtctgtgt cttatttatt gggaaattga     9600

ggccactgat atcagtgttt gttgattcct gttatattat tgttatggcg taggcccctt     9660

cccttttgat ttgctggtct gagattattt attcaggctg aagttttcct tgtagtacct     9720

tctatcaagc tggatttgta gacagaaacc acttaagttt cattttattg tagattgtca     9780

ttctttcttc atctctgtga ttaaatgttt tgctggctat agtagtctgg gctggcatct     9840

gtggtagaat gtctgcccag gacctttgac ttttagagtc tcgattgaag tcaggggtta     9900

ttctaatagg tttgtctgcc gttatatgtt atctggtctt tctctattgt ggcttttggt     9960

attctttctt tgttctgtac attctgtttt ttgattatta tgtgttgtgg ggaatttatt    10020

tttggcccag tccgtttggt gttctatttg tttcttatac catgataggc acttccttct    10080

ttaggttagg taacttttca tctgtgattt tgttgaaaat attttctgtg cctttgacct    10140

gggtttcttc tccttttgct atccctgtta cttatagatt tttggtgttt tcatagtatc    10200

ctagatttcc tggatgtttt gtgcctggat tttgttttct ttcttttttt gtagatttaa    10260

cattttcttt gactgcagta tccttgtctc ctatcttgtc ctcagtgctt gagactctgt    10320

cttccatttc ttgtatgatt ttggtgaggc ttgcttctaa gatttctgtt ctagttccta    10380

aatttttcat ttccagcttt acctcaattt gggttttctt tagcaattcc atttcctctt    10440

tcatgtgttg aacaattttc ttcatttcat tgcactgttt gtgttttcat taatgggttt    10500

attcatatct tctttaggga ccttgaacat attcataata gctattctga gagccttgtc    10560

ttatgcttcc ctgtattgca tttctcggag cctgctgtgg tagggttgct gggctctagt    10620

ggagacatgt cgttctggct gttactgggt ttttacactg gtgtctaggc gactgggttt    10680

gagaagattg taattctagg tgctgatatc tggtcttgtt tttgttgggg tgatgttcag    10740

ttccttggtt tctgttgccc ccccccctca gggggggtgt ggtaactgga ttggttgcct    10800

ggtagggaat gcttctgaga tcctgccaga accctgccac tggcagtctt gggtagaaag    10860

tgtttctagg tgttgggagc tgacactaat gattgaggat gggttagaag cagtggtggc    10920

gggagagtcc acaggaggag gagagctggg tgtgccacca gggtctgcac agaggcctgg    10980

gaatgagaac agagatgaag gtgaggcctc agcaggtagt ctgctacaag gttgggataa    11040

ggctgggaga ttggaacttg gggacaggag ggagagtgaa gatcgcagac ccatcccctg    11100

gccaggtggg ggaagcctgg aggagaagat ctgtgtgatc tgctggaaat gggtccctta    11160

gtaacttctt gaagtttctt tgattttgag gctgctgttg ggggtcccct gtatgccaag    11220

catgtggtat atcactgaga tagaatctcc atagccctgc ttcttttttg agactgggtc    11280

tcatatcggc caggttggcc ttgaactagc tatgttgacc ttgaactttt ccttacctat    11340

acctgagaac tgggattaca agtgcccatc acacccagct tcctattgtt tttgcttttt    11400

tcctagtatt taagcttctg gcttccccat taaaatttaa aagatgaaag gcttagtaca    11460

cgggaagcat ccttgaaggt gcacacactt gccatataga gaggatgaag tggttctaag    11520

tcatcaggca gcagccccag gatcagacag ttcacattct ccatcatctg gttcagggga    11580

gccccacctg tactctgaat gttgcctggg aaactgtggg gacacactct tgatatttac    11640

agatgggctg cctctgggaa taaacctggg gaagaataag acttcggagg atgctgctgc    11700

agactatgta gagggtgttc gtgtcctggg ccccttggct gactacctgg tggtgaatgt    11760

gtccagtccc aacactgctg gtctgaggag cctacaggga aaggctgagc tgcgccgcct    11820

gctggccaag gtgtgtcatt acaccatcac atgcctgttg tccttactcc ttttcattct    11880

tcaggtgaag attcaggaca actgaggaga aactgttctt cacagctggc ctaggagccc    11940

tcatcacaca ttttccaagt accctctcat gtctcacagc cccggtcata cacaatagac    12000

agttcactgc tttaaaacca caggcaagca gagcagagca ggcggggctc ccatgtatca    12060

ctctgtcccc agaactgtga atgctcagca cttgtgacac acctccttgt ttgttttcag    12120

gaacaaaatc aaaacccttg agcagttatc tcggcggggg gtgcgggggt gggggaattg    12180

ctggtgcttt agttgacctt aggtgaaaat gctggcctgc actgcggggc tatgggctgg    12240

gtccccatct ctggcttgtc aacctaggtg ctgcaggaga gggacgcttt gaagggagcg    12300

cagaagccag cagtgctggt gaagatcgcc cccgacctca cggcccagga caaggaggac    12360

attgccagtg tggcgagaga ggtttgagtt ggggtggtcc agggcagggt gggggtagcc    12420

ttcatcgtcc actgctgctg ggataacaca gaagggcatg attggtgact tcctctgtgt    12480

gaagtggaca gctggttgat tgtctgtcat tgtatagttc atctggtagc aaacagtgag    12540

tttgaaaatg tgtttggtga gtctttttct tgcttctgat ctgtcttcat ccagaaagtc    12600

tgaggcctgt gctagtctct gccagtctca cctgggactt agaatggtgt ctgtcccttt    12660

ccagcttgtg taaacaccag gcttctctgg ctaaaaaggt agtaggaaca cagtctgctg    12720

ttctggactt cagtcttgtt ctactgtgta ctccctgaga tactcacaga cagcttgttc    12780

taagggtcaa actctgtgta ggcactgtga tgggttcagc aggagatgct gctgtgtctt    12840

cagcattgag aggctaattc tgatggcttc tccaatcaag atgtaggtga ggcctgtgag    12900

ggtcttgctc tgcagagctg gcccctggcc tggtggctgc ttcaatcctc aaaagacagt    12960

ttccttgagt acttcagatc catggcttaa ggctcttttt ctgtcttgtg ctgcagctgg    13020

gcattgatgg attaattgtc acaaacacca cagtgagtcg cccgactggc ctccaaggtg    13080

ctctgcgttc tgagatggga ggactgagcg ggaagccact ccgagatctg tcgacccaga    13140

ccatccggga gatgtacacc ctcactcaag gtaaggcttt tttgtttgtt tgtttgaggc    13200

aggatttctc tgtttaacac ctctggctgt cctggaactc acttggtaga ccaggctggc    13260

ctggaactca cagcttccct agtgctggga ttaaaggcat gtgccaccat tgcctggcta    13320

aggcaagact tctttggaca aatgtgaggt cctggatctt ccctcattca ctgtgtttgc    13380

tgagaactct ggttctgccc tcatcggctg tgtttgctgg gactgaggcc tgatggagcc    13440

ctgggtcttt agccctccct tcccggcctt gctatgtgct tctctccagg caggattccc    13500

attatcgggg ttggtggtgt gagcagtggg caagatgcgc tggagaagat ccaggcaggg    13560

gcctccctgg tgcagctgta cacggccctc accttcctgg ggccacccgt cgtggtcagg    13620

gtcaagcgtg agctggaggc acttctaaag tgagtagggt tcgatgcagc tgagacgtag    13680

aaagtgacac ttgtcatcag tctattgtgt actcccagag ggccggaggg aacactgagg    13740

gcatggtggg acgatttctc tgctgcagct ttggccaagg acaaacagtg ccagaggaat    13800

tcagaatgct tctgaggcag ggctcattac aaggcaggac ttgccacttg cccaggggct    13860

gggcatggag gatgaagtag taatttacat tgactcagtg tctggaagct gcaggttata    13920

aagtcacttc ccttcctgca cagaaggcct ggctgtacat atgtgcaggg gcctgggtga    13980

gggcagagta gcagtggttg taaggtgtgt tgggtgggac ggtgtggtaa gcggtgtgct    14040

catggtgagt gtgggcttcc ttaggacagg ctatttgttt tctgtccaga gagcggggtt    14100

ttaacacagt cacagaagcc attggagcag atcatcggag gtgacggttc ctgccagatg    14160

ccccatccag aacgtgccca ccaactcaag caagccttgt ggctgcatca taagaggaag    14220

atctgtctca agctatgtcc cttgactgtg tgacctggct ggactgcata agccagtcac    14280

ggttatcact agacagtaaa ggctttctct aatgagacca tgaactctac agtcactttc    14340

tggatctaag tcctgggatc cctcagtatt ataaggacat tggctctttg ggaggaaaaa    14400

tcatggagaa aataaagcca tttcaatctg ttttcaa                             14437


<210>  28
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human DHODH G202A

<400>  28

Met Ala Trp Arg His Leu Lys Lys Arg Ala Gln Asp Ala Val Ile Ile 
1               5                   10                  15      


Leu Gly Gly Gly Gly Leu Leu Phe Ala Ser Tyr Leu Met Ala Thr Gly 
            20                  25                  30          


Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly Leu 
        35                  40                  45              


Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser Leu 
    50                  55                  60                  


Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Glu Val 
65                  70                  75                  80  


Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly 
                85                  90                  95      


Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Met Gly Phe 
            100                 105                 110         


Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys Pro Gln Glu Gly Asn 
        115                 120                 125             


Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn 
    130                 135                 140                 


Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg Leu 
145                 150                 155                 160 


Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu Pro 
                165                 170                 175     


Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu 
            180                 185                 190         


Asp Tyr Ala Glu Gly Val Arg Val Leu Ala Pro Leu Ala Asp Tyr Leu 
        195                 200                 205             


Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln 
    210                 215                 220                 


Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Leu Gln Glu Arg 
225                 230                 235                 240 


Asp Gly Leu Arg Arg Val His Arg Pro Ala Val Leu Val Lys Ile Ala 
                245                 250                 255     


Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile Ala Ser Val Val Lys 
            260                 265                 270         


Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg 
        275                 280                 285             


Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu Ser 
    290                 295                 300                 


Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr 
305                 310                 315                 320 


Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly Val Gly Gly Val Ser 
                325                 330                 335     


Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu Val 
            340                 345                 350         


Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro Pro Val Val Gly Lys 
        355                 360                 365             


Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly Gly 
    370                 375                 380                 


Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395 


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  corresponding piece of DNA for generating GS gRNA

<400>  29
gagtatgtga agactttg                                                     18


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  corresponding piece of DNA for generating GS gRNA

<400>  30
ccatctttat tctcatgggg                                                   20


<210>  31
<211>  5562
<212>  DNA
<213>  Cricetulus griseus


<220>
<221>  misc_feature
<222>  (4467)..(4484)
<223>  target of GS-1 gRNA

<220>
<221>  misc_feature
<222>  (4611)..(4630)
<223>  target of GS-2 gRNA

<400>  31
accttccacc atggccacct cagcaagttc ccacttgaac aaaaacatca agcaaatgta       60

cttgtgcctg ccccagggtg agaaagtcca agccatgtat atctgggttg atggtactgg      120

agaaggactg cgctgcaaaa cccgcaccct ggactgtgag cccaagtgtg tagaaggtga      180

gcatgggcag gagcaggaca tgtgcctgga agtgggcaag cagcctgaga tttgaccttc      240

cttctgtttt gtttgcaaag tctttcaaaa gcaggtctct tcaggcctca gtcagtcacc      300

cgtaagctgc cgagtagtct ggaggcatag aaaacaatgg aggcctttat ttagatggaa      360

tcttgtgtgt gctggtacac tgaagaaaaa tattgggtca tatttgtagg gggtgggagg      420

ttggagtatt gctaacctag ccaaccccag gaacctagtt tgaaagacct gtaactagaa      480

tatgctatca agtttataga gcagtggttc tcaacctttc aaatgcttta cacttgaata      540

caactcctca tgttctggtg attaccccca tcccaaccat tgctaacttc ttaactgaaa      600

tttcactact gctacgaatc ataatgtatc tgtgtttttg gatggtctta ggtgacccct      660

gtgaaagggt tgtgagacca tcctcaaagg ggttgtgacc tacaggttga gacccttttg      720

agtgctgtgt ttattagtat ttatacagtg gaattctggg tgcaaagcac atgctccaaa      780

gtagtttctc tgggactggc catttgtttt cagatgggga tacttttaaa aacttgcaaa      840

ggaaccaaaa aaaaaaaaaa tgcagaaaaa aggagggggg ggagggcacg cctttaatcc      900

cagtacttgg gaggcagagg caggcggatc tctgtgagtt gaagcccagc ctggtctaca      960

agagctagtt ccaggacagc ctccaaagcc acagagaaac cctgtctcaa aacaaacaaa     1020

cacacaaaaa aattaaaaaa aaaaaaaaac tttcaaagga gacctgtttt attttagttg     1080

tggcctttgt tttggtagga agggcagcta gtttaggatg agtttttatt attctaagat     1140

gttgccgttt gagtgaatga atgaccagat gacagcatat aacatgtact tgttacttgg     1200

cagaagtagg taggtcgttc tgtttctgcc ttcagctcat aggtaactgg ggagacaaac     1260

tggccccaaa acaaggaaaa ggaacaagtg gtaggagagc aactgtttcc tcatctacaa     1320

gagcacagcc tgagctacaa cagtcaggcc cggagaggga tgagagaagg gaggggatga     1380

ggtggcctag tgagggagtc agttttgctc tgtgccatga gtgtctcact cactggaagt     1440

ggtgtcagaa tgactggtgc acagtagact tacagagagg actcatctgt ttgttgcttg     1500

ggtggttctt gtgatgcagt gctcttggga acctcagaag gaggaacata gggataggtg     1560

ggcatagaca tcaggttgtc cctaattaat gatgatacat ttacatacat gccactcaga     1620

agacacagta gattttcagt gatggaaata tgatgagagg ctagctgtct tgtgtgtata     1680

tttttaataa atttttaata aatttcatgt gtgtgagtca gtgcgtgtgt gcgtttgctc     1740

gcccagtgct gtgccagcag aggtctgagg agggtgtgag aatcccagga actgaagtta     1800

acagttgtgg ttaagagtac ttatcactcg ttaccagcac ctacatggtg gctcacaacc     1860

atctgtaact ccaatttcag gggctccaac cccctcttct gcaggcatac acttgcacag     1920

atatacatgc aagtaaaaca cccctacaca cataaaaata aatacgtctt cttaaaagtt     1980

aattttccat ctttatttgg cccagagtta cctgagtgga attttgatgg ctctagtacc     2040

tttcagtctg agggctccaa cagtgacatg tatctcagcc ctgttgccat gtttcgggac     2100

cccttccgca gagatcccaa caagctggtg ttctgtgaag ttttcaagta caaccggaag     2160

cctgcaggtg tgtatggggt gggcgtgaat gtcttaagaa tctagggatg gatgatcaga     2220

tgtccatcct tctaccctga acttgcctgc tgaaaaacag tgtggtccgc ccctccatgg     2280

tcccttttat tggttgtata aacagtgttg aatcttccat ctgtttgctg ataggggtcc     2340

ccagtgacag tcttgatctg cttctacatt taaaaagctg taattcgtac ttaagcgttt     2400

tggggtttaa ctactagatc tgccatttat tgccagtgac cttggcatac tttgccccat     2460

gcttctattt tgctgaatta tgtgtagaga gagacgagac agagcatgct tgaactgagg     2520

gcgtactgtg ctctgtgtgg aagtcaaccg acaacctgtg gaatcagttc tctcctgctg     2580

tatttgtaga ttctggaggt ggaactcagg ttgccatgag cattatgatt cctggctaag     2640

ctgtttgccc atgaagcctt ctgtacctgc tcatagaatt ttgtttatgc cgtgctatcc     2700

atactcagtt ttcagatagc ttcttaaacc cagggaactc taatttacat aaactctctt     2760

ccagtactgc cagtaaggct tggtggccct ataccttcag tacctctgtt ttgaaaagga     2820

agtattgttg gtcaagggta tgtacctcag catggcagcc atggggttcc tggctgtgcc     2880

gcttgcccta taacctgggc acgtcaccaa acaccctctc tcagggcttc attttctcat     2940

ttgtgaaagt gaagattgct aacactcatc tcaaactcag ttaaatgata aattgctttt     3000

ctagcttggg aattgttttc agttacactc acctctccct cgctttctct ctcttttttg     3060

taccagccaa tactgtgtaa tttagcactc agactcacct ggaatgtaaa cctaatggac     3120

aaattattct cagtaaaatg acagctctgg ccttaagtgc ctacgaaact agggaatacg     3180

tttgacaagc aggagcagct gtcttgtgaa tagagggtgg aagtgtctgg catgtggtac     3240

ttggaaagtg gccagcgtgc agataggatg aacacttgtt ttgctctcac tccattccca     3300

tgagatttca tagctgactt taattataaa aagtctctca gccttttcct gcaaatgtac     3360

tatcattgct tcttcacagt ggttgggcct gagtaggtcc agcctatgat gacttcagct     3420

gtgtaagagt tgaggacact actccttaca gcatgttgat gctttattcc tagagaccaa     3480

tttaaggcac tcgtgtaaac ggataatgga catggtgagc aaccagcacc cctggtttgg     3540

aatggaacag gagtatactc tgatgggaac agatgggcac ccttttggtt ggccttccaa     3600

tggctttcct gggccccaag gtaagttccc caggtgaaat aaaagcttcc tccccataag     3660

ttcttactgt ccagagacag gagcagctcc caaatcagca aacagactgg cagctgaaaa     3720

taacagactg tccttgcatc cctcaaatcc agatgtgctt tgaatttaaa gtgacaggat     3780

ggtgatgaga tggctcagtg ggtaaaggtg cttgccacca ggcttgacag cccgagttta     3840

tccctgagac ccatataagt tattctctga ccatctgcac atgcatgcat atacaaaaag     3900

tgaaaagcta ttcagagtgg gcagtagttc taccaaggct acagcaaaga ggaaagacct     3960

agcctcctac ctgcaggtga agacaggatg tgcgaaagca agtcttagga ccttgtcatt     4020

ttctggcttt ggggggttat ggactctgat tcttcactga ttgctcttga ttctccttca     4080

ggtccgtatt actgtggtgt gggcgcagac aaagcctatg gcagggatat cgtggaggct     4140

cactaccgcg cctgcttgta tgctggggtc aagattacag gaacaaatgc tgaggtcatg     4200

cctgcccagg taaatggcac tattctgttc cttttcctcc cctctgaaga cttggcacat     4260

ggggactttg gttaacaagg gtgatgactt aaaagtggtt cagggtagag gtaagtagaa     4320

caagctagga gcttgagttg gcctgaacag ttagttggcc ttattctaaa ggtcaacatg     4380

ttctttctag tgggaattcc aaataggacc ctgtgaagga atccgcatgg gagatcatct     4440

ctgggtggcc cgtttcatct tgcatcgagt atgtgaagac tttggggtaa tagcaacctt     4500

tgaccccaag cccattcctg ggaactggaa tggtgcaggc tgccatacca actttagcac     4560

caaggccatg cgggaggaga atggtctgaa gtaagtagct tcctctggag ccatctttat     4620

tctcatgggg tggaagggct ttgtgttagg gttgggaaag ttggacttct cacaaactac     4680

atgccatgct cttcgtgttt gtcataagcc tatcgttttg tacccgttgg agaagtgaca     4740

gtactctagg aatagaatta cagctgtgat atgggaaagt tgtcacgtag gttcaagcat     4800

ttaaaggtct ttagtaagaa ctaaatacac atacaagcaa gtgggtgact taattcttac     4860

tgatgggaag aggccagtga tgggggtctt cccatccaaa agataattgg tattacatgt     4920

tgaggactgg tctgaagcac ttgagacata ggtcacaagg cagacacagc ctgcatcaag     4980

tatttattgg tttcttatgg aactcatgcc tgctcctgcc cttgaaggac aggtttctag     5040

tgacaaggtc agaccctcac ctttactgct tccaccaggc acatcgagga ggccatcgag     5100

aaactaagca agcggcaccg gtaccacatt cgagcctacg atcccaaggg gggcctggac     5160

aatgcccgtc gtctgactgg gttccacgaa acgtccaaca tcaacgactt ttctgctggt     5220

gtcgccaatc gcagtgccag catccgcatt ccccggactg tcggccagga gaagaaaggt     5280

tactttgaag accgccgccc ctctgccaat tgtgacccct ttgcagtgac agaagccatc     5340

gtccgcacat gccttctcaa tgagactggc gacgagccct tccaatacaa aaactaatta     5400

gactttgagt gatcttgagc ctttcctagt tcatcccacc ccgccccagc tgtctcattg     5460

taactcaaag gatggaatat caaggtcttt ttattcctcg tgcccagtta atcttgcttt     5520

tattggtcag aatagaggag tcaagttctt aatccctata ca                        5562


<210>  32
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS1_F primer

<400>  32
acactctttc cctacacgac gctcttccga tcttggcctt attctaaagg tcaaca           56


<210>  33
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS1_R primer

<400>  33
gtgactggag ttcagacgtg tgctcttccg atctcattct cctcccgcat gg               52


<210>  34
<211>  1417
<212>  DNA
<213>  Cricetulus griseus

<400>  34
ccgagccgag aatgggagta gagccgactg cttgattccc acaccaatct cctcgccgct       60

ctcacttcgc ctcgttctcg tggctcgtgg ccctgtccac cccgtccatc atcccgccgg      120

ccaccgctca gagcaccttc caccatggcc acctcagcaa gttcccactt gaacaaaaac      180

atcaagcaaa tgtacttgtg cctgccccag ggtgagaaag tccaagccat gtatatctgg      240

gttgatggta ctggagaagg actgcgctgc aaaacccgca ccctggactg tgagcccaag      300

tgtgtagaag agttacctga gtggaatttt gatggctcta gtacctttca gtctgagggc      360

tccaacagtg acatgtatct cagccctgtt gccatgtttc gggacccctt ccgcagagat      420

cccaacaagc tggtgttctg tgaagttttc aagtacaacc ggaagcctgc agagaccaat      480

ttaaggcact cgtgtaaacg gataatggac atggtgagca accagcaccc ctggtttgga      540

atggaacagg agtatactct gatgggaaca gatgggcacc cttttggttg gccttccaat      600

ggctttcctg ggccccaagg tccgtattac tgtggtgtgg gcgcagacaa agcctatggc      660

agggatatcg mggaggctca ctaccgcgcc tgcttgtatg ctggggtcaa gattacagga      720

acaaatgctg aggtcatgcc tgcccagtgg gaattccaaa taggaccctg tgaaggaatc      780

cgcaggagat catctctggg tggcccgttt catcttgcat cgagtatgtg aagactttgg      840

ggtaatagca acctttgacc ccaagcccat tcctgggaac tggaatggtg caggctgcca      900

taccaacttt agcaccaagg ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc      960

catcgagaaa ctaagcaagc ggcaccggta ccacattcga gcctacgatc ccaagggggg     1020

cctggacaat gcccgtggtc tgactgggtt ccacgaaacg tccaacatca acgacttttc     1080

tgctggtgtc gccaatcgca gtgccagcat ccgcattccc cggactgtcg gccaggagaa     1140

gaaaggttac tttgaagacc gccgcccctc tgccaattgt gacccctttg cagtgacaga     1200

agccatcgtc cgcacatgcc ttctcaatga gactggcgac gagcccttcc aatacaaaaa     1260

ctaattagac tttgagtgat cttgagcctt tcctagttca tcccaccccg ccccagctgt     1320

ctcattgtaa ctcaaaggat ggaatatcaa ggtcttttta ttcctcgtgc ccagttaatc     1380

ttgcttttat tggtcagaat agaggagtca agttctt                              1417


<210>  35
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS F primer

<400>  35
acctttgacc ccaagc                                                       16


<210>  36
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS R primer

<400>  36
cgtcgccagt ctcattg                                                      17


