                         SEQUENCE LISTING

<110>  ˹＼麣޹˾
 
<120>  4-1BBĵ塢ںϵסҩＰ;

<130>  IEC210274PCT

<150>  CN202010981835.5
<151>  2020-09-17

<150>  CN202011025265.9
<151>  2020-09-25

<160>  174   

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn 
            20                  25                  30          


Thr Gly Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys His 
                85                  90                  95      


Ile Gly Pro Glu Pro Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn 
            20                  25                  30          


Thr Gly Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Glu Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys His 
                85                  90                  95      


Ile Gly Pro Glu Pro Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn 
            20                  25                  30          


Thr Gly Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys His 
                85                  90                  95      


Ile Gly Pro Glu Pro Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Leu Tyr Thr Gly Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Glu Thr Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Lys Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Glu Leu Leu Gly Ser Gly Glu Gly Cys Tyr Val Trp Ser Arg 
            100                 105                 110         


Asp Gly Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn 
            20                  25                  30          


Thr Gly Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys His 
                85                  90                  95      


Ile Gly Pro Glu Pro Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  9

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Tyr Tyr Thr Gly Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Gln Ser Asp Cys Phe His Tyr Ser Glu Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Gln Ser Asp Cys Phe His Tyr Ser Glu Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Pro Arg Ser Asp Cys Phe His Tyr Gly Glu Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Thr Ala Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Arg Ser Asp Cys Phe His Tyr Gly Glu Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Glu Lys Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Ser Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Gln Ser Asp Cys Phe His Tyr Lys Glu Asn Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Leu Tyr Thr Gly Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Ala Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Leu Tyr Thr Gly Asp Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Tyr Tyr Thr Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Leu Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Phe Asn Ala Met Gly 
            20                  25                  30          


Trp Trp Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val Ala Ile Ile 
        35                  40                  45              


Thr Arg Asp Gly Ser Thr Asn Leu Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Trp Phe Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser Ala Ser Asp 
                85                  90                  95      


Tyr Gly Ser Ser Leu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  24
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ile Thr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ala Ser Gly Asp Gly Ala Thr Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Pro Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Asp Ser Gly Arg Ile Phe Ser Tyr Asn Phe 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
        35                  40                  45              


Ser Ile Thr Trp Gly Gly Thr Ile Lys Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg His Asp Ala Glu Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys His Ala 
                85                  90                  95      


Ala Thr Asp Thr Gly Val Ile Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Gly Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Glu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Leu Thr Gly Leu Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Thr Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys Ala 
                85                  90                  95      


Ala Thr Gly Tyr Gly Ser Ser Pro Trp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Ile Thr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Arg Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Arg Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Val Ile Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ala Ser Gly Asp Gly Ala Thr Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Arg Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Trp Leu Glu Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  35
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  35

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Val 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ile Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Leu Ile Arg Tyr Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ile Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Lys Ser Ala Tyr Ile Phe Asp Asp Arg Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn 
            20                  25                  30          


Thr Gly Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ile Gly Pro Glu Pro Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn 
            20                  25                  30          


Thr Gly Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ile Gly Pro Glu Pro Arg Tyr Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Val 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Val 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  41

Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn Thr Gly Ala 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  42

Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn Thr Gly Ala 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  43

Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn Thr Gly Ala 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  44

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  45

Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  46

Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn Thr Gly Ala 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  47

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  48

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  49

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  50

Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr Ala Ile Gly 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  51

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  52

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  53

Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr Ala Ile Gly 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  54

Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr Ala Ile Gly 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  55

Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr Ala Ile Gly 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  56

Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr Ala Ile Ala 
1               5                   10              


<210>  57
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  57

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  58

Ala Ala Ser Gly Phe Ser Leu Gly Leu Tyr Ala Ile Gly 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  59

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  60

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  61
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  61

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  62

Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10              


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  63

Ala Ala Ser Gly Ser Phe Asn Ala Met Gly 
1               5                   10  


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  64

Ala Ala Ser Gly Gly Thr Phe Ser Ile Thr Ala Met Gly 
1               5                   10              


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  65

Asp Ser Gly Arg Ile Phe Ser Tyr Asn Phe Met Gly 
1               5                   10          


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  66

Ala Ala Ser Gly Arg Thr Leu Ser Gly Tyr Val Met Gly 
1               5                   10              


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  67

Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn Val Met Gly 
1               5                   10              


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  68

Ala Ala Ser Gly Ser Thr Phe Gly Ile Thr Ala Met Gly 
1               5                   10              


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  69

Ala Ala Ser Gly Ser Thr Phe Ser Ile Ser Ala Met Gly 
1               5                   10              


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  70

Ala Ala Ser Gly Ser Thr Phe Ser Ile Ser Ala Met Gly 
1               5                   10              


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  71

Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr Ala Met Gly 
1               5                   10              


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  72

Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr Ala Met Gly 
1               5                   10              


<210>  73
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  73

Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr Ala Met Gly 
1               5                   10              


<210>  74
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  74

Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr Ala Met Gly 
1               5                   10              


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  75

Ala Ala Ser Gly Ser Thr Phe Ser Ile Val Ala Met Gly 
1               5                   10              


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  76

Ala Ala Ser Arg Ser Ile Phe Ser Ser Tyr Val Met Ala 
1               5                   10              


<210>  77
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  77

Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn Thr Gly Ala 
1               5                   10              


<210>  78
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  78

Ala Ala Ser Gly Ala Ile Phe Arg Ile Asn Thr Gly Ala 
1               5                   10              


<210>  79
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  79

Ala Ala Ser Gly Ser Thr Phe Ser Ile Val Ala Met Gly 
1               5                   10              


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  80

Ala Ala Ser Gly Ser Thr Phe Ser Ile Val Ala Met Gly 
1               5                   10              


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  81

Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  82

Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  83

Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  84

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  85

Cys Ile Ser Ser Ser Gly Glu Thr Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  86

Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  87

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  88

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  89

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  90

Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  91

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  92

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  93

Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  94

Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  95

Cys Ile Thr Ala Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  96

Cys Ile Glu Lys Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  97

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  98

Cys Ile Met Ser Ser Asp Ser Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  99

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  100

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  101

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  102

Cys Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  103

Ile Ile Thr Arg Asp Gly Ser Thr Asn Leu Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  104

Ala Ile Ala Ser Gly Asp Gly Ala Thr Asn Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  105

Ser Ile Thr Trp Gly Gly Thr Ile Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  106

Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Glu Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  107

Val Ile Thr Ser Asp Tyr Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  108

Ala Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  109

Leu Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  110

Ala Ile Val Ile Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  111

Ala Ile Ala Ser Gly Asp Gly Ala Thr Asn Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  112

Ala Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  113

Ala Ile Ile Met Ser Asp Gly Asp Thr Asn Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  114

Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  115

Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  116

Leu Ile Arg Tyr Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  117
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  117

Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  118

Ser Leu Thr Thr Tyr Gly Lys Thr Thr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  119

Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  120

Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  121

His Ile Gly Pro Glu Pro Arg Tyr Gly Tyr 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  122

His Ile Gly Pro Glu Pro Arg Tyr Gly Tyr 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  123

His Ile Gly Pro Glu Pro Arg Tyr Gly Tyr 
1               5                   10  


<210>  124
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  124

Gly Ala Pro Arg Asp Cys Ser Leu Tyr Thr Gly Asp Asp Tyr 
1               5                   10                  


<210>  125
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  125

Gly Ala Glu Leu Leu Gly Ser Gly Glu Gly Cys Tyr Val Trp Ser Arg 
1               5                   10                  15      


Asp Gly Ser Tyr 
            20  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  126

His Ile Gly Pro Glu Pro Arg Tyr Gly Tyr 
1               5                   10  


<210>  127
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  127

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  128
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  128

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  129
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  129

Gly Ala Pro Arg Asp Cys Ser Tyr Tyr Thr Gly Asp Asp Tyr 
1               5                   10                  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  130

Ala Ala Pro Gln Ser Asp Cys Phe His Tyr Ser Glu Asn Asp Tyr 
1               5                   10                  15  


<210>  131
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  131

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  132
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  132

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  133

Ala Ala Pro Gln Ser Asp Cys Phe His Tyr Ser Glu Asn Asp Tyr 
1               5                   10                  15  


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  134

Thr Ala Pro Arg Ser Asp Cys Phe His Tyr Gly Glu Asn Asp Tyr 
1               5                   10                  15  


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  135

Ala Ala Pro Arg Ser Asp Cys Phe His Tyr Gly Glu Asn Asp Tyr 
1               5                   10                  15  


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  136

Ala Ala Pro Gln Ser Asp Cys Phe His Tyr Lys Glu Asn Asp Tyr 
1               5                   10                  15  


<210>  137
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  137

Gly Ala Pro Arg Asp Cys Ser Leu Tyr Thr Gly Asp Asp Tyr 
1               5                   10                  


<210>  138
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  138

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  139

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  140
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  140

Gly Ala Pro Arg Asp Cys Ser Leu Tyr Thr Gly Asp Asp Tyr 
1               5                   10                  


<210>  141
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  141

Gly Ala Pro Arg Asp Cys Ser Tyr Tyr Thr Ser Asp Asp Tyr 
1               5                   10                  


<210>  142
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  142

Gly Ala Pro Arg Asp Cys Ser Arg Tyr Ser Ser Asp Asp Tyr 
1               5                   10                  


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  143

Ser Ala Ser Asp Tyr Gly Ser Ser Leu Tyr Tyr 
1               5                   10      


<210>  144
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  144

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Pro Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  145

His Ala Ala Thr Asp Thr Gly Val Ile Tyr 
1               5                   10  


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  146

Ala Ala Asp Pro Arg Arg Leu Thr Gly Leu Tyr Asp Tyr 
1               5                   10              


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  147

Ala Ala Thr Gly Tyr Gly Ser Ser Pro Trp Tyr 
1               5                   10      


<210>  148
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  148

Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Arg Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  149
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  149

Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Arg Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  150
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  150

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  151
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  151

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  152
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  152

Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Arg Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  153
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  153

Tyr Ala Arg Thr Gly Tyr Gly Ser Gly Trp Leu Glu Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  154
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  154

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  155
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  155

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  156
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  156

Ala Ala Ser Lys Ser Ala Tyr Ile Phe Asp Asp Arg Asp Tyr 
1               5                   10                  


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  157

His Ile Gly Pro Glu Pro Arg Tyr Gly Tyr 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  158

His Ile Gly Pro Glu Pro Arg Tyr Gly Tyr 
1               5                   10  


<210>  159
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  159

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  160

Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  161
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  161
gtcctggctg ctcttctaca agg                                               23


<210>  162
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  162
ggtacgtgct gttgaactgt tcc                                               23


<210>  163
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  163
ctagtgcggc cgcctggaga cggtgacctg ggt                                    33


<210>  164
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  164
cgcggatccc aggtgcagct gcaggagtct ggrggagg                               38


<210>  165
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  165
atttttactg ctgttttatt cgcagcatcc tccgcattag ctaaaagaga ggctgaagca       60

caggtgcagc tgcaggagtc tggrggagg                                         89


<210>  166
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  166
agttgtcagt tcctgtgccc cccctcctcc cgcgccacct ccgcccgcac ctccgccacc       60

actggagacg gtgacctggg t                                                 81


<210>  167
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1Fc

<400>  167

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


<210>  168
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Դ4-1BB

<400>  168

Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn Asn 
1               5                   10                  15      


Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser Ala 
            20                  25                  30          


Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val Phe 
        35                  40                  45              


Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp Cys 
    50                  55                  60                  


Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu Gln 
65                  70                  75                  80  


Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp Cys 
                85                  90                  95      


Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro Trp 
            100                 105                 110         


Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr Lys 
        115                 120                 125             


Glu Arg Asp Val Val Cys Gly Pro Ser Pro Leu Gly 
    130                 135                 140 


<210>  169
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ᾧеĿ4-1BBİ

<400>  169

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Val 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ile Thr Gly Asp Gly Asp Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Arg Thr Gly Tyr Gly Ser Ser Trp Leu Met Gly His Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Leu Gly 
        115                 120                 125         


<210>  170
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys 
            20          


<210>  171
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2

<400>  171

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  172
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2

<400>  172

Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val Ala 
1               5                   10                  


<210>  173
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3

<400>  173

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4

<400>  174

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


