﻿                         序列表

<110>  四川科伦博泰生物医药股份有限公司
 
<120>  抗Nectin-4抗体、包含所述抗体的缀合物及其应用

<130>  P2021TC1734

<150>  CN202010972365.6
<151>  2020-09-16

<150>  CN202011624826.7
<151>  2020-12-31

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31#VH

<400>  1

Glu Val Gln Leu Gln Gln Pro Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Leu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Arg Ile Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31#VL

<400>  2

Asp Val Val Ile Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Asn Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  31#/31HZ  CDR-H1

<400>  3

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  31# /31HZ CDR-H2

<400>  4

His Pro Ser Asp Ser Glu 
1               5       


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  31# /31HZ  CDR-H3

<400>  5

Trp Asp Phe Arg Ile Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  31# /31HZ CDR-L1

<400>  6

Lys Ser Ser Gln Ser Leu Leu Asn Thr Asn Ser Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  31#  /31HZ CDR-L2

<400>  7

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat/IMGT 31#/31HZ/74#/74HZ CDR-L3

<400>  8

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  31#/31HZ CDR-H1

<400>  9

Gly Tyr Thr Phe Thr Asp Tyr Trp Met Asn 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  31#  /31HZ CDR-H2

<400>  10

Met Ile His Pro Ser Asp Ser Glu Thr Arg 
1               5                   10  


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  31#  /31HZ CDR-H1

<400>  11

Asp Tyr Trp Met Asn 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  31# CDR-H2

<400>  12

Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  31# /31HZ  CDR-H1

<400>  13

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  31#/31HZ  CDR-H2

<400>  14

Ile His Pro Ser Asp Ser Glu Thr 
1               5               


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  31# /31HZ  CDR-H3

<400>  15

Ala Arg Trp Asp Phe Arg Ile Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  31# /31HZ  CDR-L1

<400>  16

Gln Ser Leu Leu Asn Thr Asn Ser Gln Lys Asn Tyr 
1               5                   10          


<210>  17
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  31# /31HZ CDR-L2

<400>  17

Phe Ala Ser 
1           


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  56HZ  CDR-H1

<400>  18

Gly Tyr Phe Asn Ser Ile Thr Ser Asp Tyr 
1               5                   10  


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  56#VH

<400>  19

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Asp Trp His Trp Ile Arg His Phe Pro Gly Asn Met Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Phe Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr His Asp Thr Ser Lys Asn His Phe Phe 
65                  70                  75                  80  


Leu Arg Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  20
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  56#VL

<400>  20

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln His Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Lys Ser Trp Pro Thr 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  56# CDR-H1

<400>  21

Gly Tyr Ser Ile Thr Ser Asp Tyr 
1               5               


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  56#/56HZ  CDR-H2

<400>  22

Ser Phe Ser Gly Arg 
1               5   


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  56#  /56HZ  CDR-H3

<400>  23

Gly Asn Tyr Asp Gly Phe Asp Tyr 
1               5               


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  56# /56HZ   CDR-L1

<400>  24

Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  56# /56HZ  CDR-L2

<400>  25

Phe Ala Ser Glu Ser Ile Ser 
1               5           


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat/IMGT  56#/56HZ   CDR-L3

<400>  26

Gln Gln Ser Lys Ser Trp Pro Thr Tyr Thr 
1               5                   10  


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  56# CDR-H1

<400>  27

Gly Tyr Ser Ile Thr Ser Asp Tyr Asp Trp His 
1               5                   10      


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  56# /56HZ  CDR-H2

<400>  28

Tyr Ile Ser Phe Ser Gly Arg Thr Tyr 
1               5                   


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  56# CDR-H1

<400>  29

Ser Asp Tyr Asp Trp His 
1               5       


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  56#/56HZ   CDR-H2

<400>  30

Tyr Ile Ser Phe Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  56# CDR-H1

<400>  31

Gly Tyr Ser Ile Thr Ser Asp Tyr Asp 
1               5                   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  56#/56HZ   CDR-H2

<400>  32

Ile Ser Phe Ser Gly Arg Thr 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  56# /56HZ   CDR-H3

<400>  33

Ala Arg Gly Asn Tyr Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  56# /56HZ  CDR-L1

<400>  34

Gln Asn Ile Gly Thr Ser 
1               5       


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  56#/56HZ   CDR-L2

<400>  35

Phe Ala Ser 
1           


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  56HZ  CDR-H1

<400>  36

Gly Tyr Phe Asn Ser Ile Thr Ser Asp Tyr Asp Trp His 
1               5                   10              


<210>  37
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  74#VH

<400>  37

Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Ala Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asn Phe Tyr Thr Val Asn Ala Trp Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly His Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  38
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  74#VL

<400>  38

Asp Ile Val Ile Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Thr Leu Leu Asn Ser 
            20                  25                  30          


Asn Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Phe Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  74#/74HZ  CDR-H1

<400>  39

Gly Tyr Thr Phe Ile Asn Tyr 
1               5           


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia  74#/74HZ  CDR-H2

<400>  40

His Pro Ser Asp Ser Ala 
1               5       


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat 74#/74HZ  CDR-H3

<400>  41

Trp Gly Asn Phe Tyr Thr Val Asn Ala Trp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  74#/74HZ  CDR-L1

<400>  42

Lys Ser Ser Gln Thr Leu Leu Asn Ser Asn Thr Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chothia/Abm/ Kabat  74#/74HZ  CDR-L2

<400>  43

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Kabat  56HZ  CDR-H1

<400>  44

Ile Thr Ser Asp Tyr Asp Trp His 
1               5               


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  74#/74HZ  CDR-H1

<400>  45

Gly Tyr Thr Phe Ile Asn Tyr Trp Met Asn 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abm  74#/74HZ  CDR-H2

<400>  46

Met Ile His Pro Ser Asp Ser Ala Thr Arg 
1               5                   10  


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  74#  /74HZ CDR-H1

<400>  47

Asn Tyr Trp Met Asn 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  74# CDR-H2

<400>  48

Met Ile His Pro Ser Asp Ser Ala Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  74#/74HZ  CDR-H1

<400>  49

Gly Tyr Thr Phe Ile Asn Tyr Trp 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  74#/74HZ CDR-H2

<400>  50

Ile His Pro Ser Asp Ser Ala Thr 
1               5               


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  74#/74HZ CDR-H3

<400>  51

Ala Arg Trp Gly Asn Phe Tyr Thr Val Asn Ala Trp Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  74#/74HZ  CDR-L1

<400>  52

Gln Thr Leu Leu Asn Ser Asn Thr Gln Lys Asn Tyr 
1               5                   10          


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  74#/74HZ CDR-L2

<400>  53

Phe Ala Ser 
1           


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMGT  56HZ  CDR-H1

<400>  54

Gly Tyr Phe Asn Ser Ile Thr Ser Asp Tyr Asp 
1               5                   10      


<210>  55
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31HZ  VH

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Arg Ile Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31HZ  VL

<400>  56

Asp Val Val Ile Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Asn Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  56HZ  VH

<400>  57

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Phe Asn Ser Ile Thr 
            20                  25                  30          


Ser Asp Tyr Asp Trp His Trp Ile Arg His His Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Tyr Ile Ser Phe Ser Gly Arg Thr Tyr Tyr Asn Pro 
    50                  55                  60                  


Ser Leu Lys Ser Arg Val Thr Ile Ser His Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asn Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  56HZ  VL

<400>  58

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln His Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys Ser Trp Pro Thr 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  59
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  74HZ  VH

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Ala Thr Arg Leu Asn Gln Ser Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asn Phe Tyr Thr Val Asn Ala Trp Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  60
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  74HZ  VL

<400>  60

Asp Ile Val Ile Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Leu Leu Asn Ser 
            20                  25                  30          


Asn Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Phe Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  61
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1重链恒定区

<400>  61

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa轻链恒定区

<400>  62

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat  31HZ CDR-H2

<400>  63

Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kabat 74HZ CDR-H2

<400>  64

Met Ile His Pro Ser Asp Ser Ala Thr Arg Leu Asn Gln Ser Phe Gln 
1               5                   10                  15      


Gly 
    


                                                                           