                         SEQUENCE LISTING

<110>  Suzhou Neologics Bioscience Co. ,Ltd.
 
<120>  PD-L1 ANTIBODIES, FUSION PROTEINS, AND USES THEREOF

<130>  135A001WO01

<160>  201   

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human PD-L1 extracellular domain

<400>  1

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  2
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  mouse IgG2a

<400>  2

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  3
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  human IgG1

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  4
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  human PD-L1 extracellular portion fused with mouse IgG2a Fc 
       portion

<400>  4

Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn 
1               5                   10                  15      


Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala 
            20                  25                  30          


Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe 
        35                  40                  45              


Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln 
    50                  55                  60                  


Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu 
65                  70                  75                  80  


Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met 
                85                  90                  95      


Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn 
            100                 105                 110         


Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Arg Gly Pro Thr Ile 
    210                 215                 220                 


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
                245                 250                 255     


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
            260                 265                 270         


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
        275                 280                 285             


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
    290                 295                 300                 


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
        355                 360                 365             


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
    370                 375                 380                 


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
                405                 410                 415     


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
            420                 425                 430         


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  5
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  The human PD-L1 extracellular portion fused with human IgG1 Fc 
       portion

<400>  5

Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn 
1               5                   10                  15      


Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala 
            20                  25                  30          


Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe 
        35                  40                  45              


Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln 
    50                  55                  60                  


Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu 
65                  70                  75                  80  


Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met 
                85                  90                  95      


Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn 
            100                 105                 110         


Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  6
<211>  225
<212>  PRT
<213>  artificial sequence

<220>
<223>  human PD-L1 extracellular portion fused with 6XHIS

<400>  6

Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn 
1               5                   10                  15      


Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala 
            20                  25                  30          


Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe 
        35                  40                  45              


Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln 
    50                  55                  60                  


Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu 
65                  70                  75                  80  


Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met 
                85                  90                  95      


Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn 
            100                 105                 110         


Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg His His His His His 
    210                 215                 220                 


His 
225 


<210>  7
<211>  567
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 1 full length

<400>  7

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  8
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 1 ECD 1-136

<400>  8

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210>  9
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 1ECD mutant 1-136

<400>  9

Ile Gly Gly Ser Val Gln Gly Ser Val Gly Gly Ser Met Ile Val Thr 
1               5                   10                  15      


Gly Gly Ser Gly Ala Val Gly Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


<210>  10
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 1 ECD N-terminal truncation 20-136

<400>  10

Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
1               5                   10                  15      


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
            20                  25                  30          


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
        35                  40                  45              


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
    50                  55                  60                  


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
65                  70                  75                  80  


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
                85                  90                  95      


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
            100                 105                 110         


Thr Ser Asn Pro Asp 
        115         


<210>  11
<211>  130
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 1: ECD C-terminal truncation 1-130

<400>  11

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr 
    130 


<210>  12
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 1: ECD C-terminal truncation 1-127

<400>  12

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125         


<210>  13
<211>  592
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 2 full length

<400>  13

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  14
<211>  161
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 2 ECD

<400>  14

Ile Pro Pro His Val Gln Lys Ser Asp Val Glu Met Glu Ala Gln Lys 
1               5                   10                  15      


Asp Glu Ile Ile Cys Pro Ser Cys Asn Arg Thr Ala His Pro Leu Arg 
            20                  25                  30          


His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
        35                  40                  45              


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
    50                  55                  60                  


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
65                  70                  75                  80  


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
                85                  90                  95      


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
            100                 105                 110         


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
        115                 120                 125             


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
    130                 135                 140                 


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro 
145                 150                 155                 160 


Asp 
    


<210>  15
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 2 ECD (NT truncation, missing NT 44 aa)

<400>  15

Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
1               5                   10                  15      


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
            20                  25                  30          


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
        35                  40                  45              


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
    50                  55                  60                  


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
65                  70                  75                  80  


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
                85                  90                  95      


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
            100                 105                 110         


Thr Ser Asn Pro Asp 
        115         


<210>  16
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  TGF-betaRII isoform 2 ECD (CT truncation, missing CT 128-161)

<400>  16

Ile Pro Pro His Val Gln Lys Ser Asp Val Glu Met Glu Ala Gln Lys 
1               5                   10                  15      


Asp Glu Ile Ile Cys Pro Ser Cys Asn Arg Thr Ala His Pro Leu Arg 
            20                  25                  30          


His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
        35                  40                  45              


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
    50                  55                  60                  


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
65                  70                  75                  80  


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
                85                  90                  95      


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
            100                 105                 110         


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
        115                 120                 125         


<210>  17
<211>  698
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin full length

<400>  17

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Val Pro Asp Lys Thr Val Arg Trp Cys Ala Val Ser Glu 
            20                  25                  30          


His Glu Ala Thr Lys Cys Gln Ser Phe Arg Asp His Met Lys Ser Val 
        35                  40                  45              


Ile Pro Ser Asp Gly Pro Ser Val Ala Cys Val Lys Lys Ala Ser Tyr 
    50                  55                  60                  


Leu Asp Cys Ile Arg Ala Ile Ala Ala Asn Glu Ala Asp Ala Val Thr 
65                  70                  75                  80  


Leu Asp Ala Gly Leu Val Tyr Asp Ala Tyr Leu Ala Pro Asn Asn Leu 
                85                  90                  95      


Lys Pro Val Val Ala Glu Phe Tyr Gly Ser Lys Glu Asp Pro Gln Thr 
            100                 105                 110         


Phe Tyr Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly Phe Gln Met 
        115                 120                 125             


Asn Gln Leu Arg Gly Lys Lys Ser Cys His Thr Gly Leu Gly Arg Ser 
    130                 135                 140                 


Ala Gly Trp Asn Ile Pro Ile Gly Leu Leu Tyr Cys Asp Leu Pro Glu 
145                 150                 155                 160 


Pro Arg Lys Pro Leu Glu Lys Ala Val Ala Asn Phe Phe Ser Gly Ser 
                165                 170                 175     


Cys Ala Pro Cys Ala Asp Gly Thr Asp Phe Pro Gln Leu Cys Gln Leu 
            180                 185                 190         


Cys Pro Gly Cys Gly Cys Ser Thr Leu Asn Gln Tyr Phe Gly Tyr Ser 
        195                 200                 205             


Gly Ala Phe Lys Cys Leu Lys Asp Gly Ala Gly Asp Val Ala Phe Val 
    210                 215                 220                 


Lys His Ser Thr Ile Phe Glu Asn Leu Ala Asn Lys Ala Asp Arg Asp 
225                 230                 235                 240 


Gln Tyr Glu Leu Leu Cys Leu Asp Asn Thr Arg Lys Pro Val Asp Glu 
                245                 250                 255     


Tyr Lys Asp Cys His Leu Ala Gln Val Pro Ser His Thr Val Val Ala 
            260                 265                 270         


Arg Ser Met Gly Gly Lys Glu Asp Leu Ile Trp Glu Leu Leu Asn Gln 
        275                 280                 285             


Ala Gln Glu His Phe Gly Lys Asp Lys Ser Lys Glu Phe Gln Leu Phe 
    290                 295                 300                 


Ser Ser Pro His Gly Lys Asp Leu Leu Phe Lys Asp Ser Ala His Gly 
305                 310                 315                 320 


Phe Leu Lys Val Pro Pro Arg Met Asp Ala Lys Met Tyr Leu Gly Tyr 
                325                 330                 335     


Glu Tyr Val Thr Ala Ile Arg Asn Leu Arg Glu Gly Thr Cys Pro Glu 
            340                 345                 350         


Ala Pro Thr Asp Glu Cys Lys Pro Val Lys Trp Cys Ala Leu Ser His 
        355                 360                 365             


His Glu Arg Leu Lys Cys Asp Glu Trp Ser Val Asn Ser Val Gly Lys 
    370                 375                 380                 


Ile Glu Cys Val Ser Ala Glu Thr Thr Glu Asp Cys Ile Ala Lys Ile 
385                 390                 395                 400 


Met Asn Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Phe Val Tyr 
                405                 410                 415     


Ile Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Asn 
            420                 425                 430         


Lys Ser Asp Asn Cys Glu Asp Thr Pro Glu Ala Gly Tyr Phe Ala Ile 
        435                 440                 445             


Ala Val Val Lys Lys Ser Ala Ser Asp Leu Thr Trp Asp Asn Leu Lys 
    450                 455                 460                 


Gly Lys Lys Ser Cys His Thr Ala Val Gly Arg Thr Ala Gly Trp Asn 
465                 470                 475                 480 


Ile Pro Met Gly Leu Leu Tyr Asn Lys Ile Asn His Cys Arg Phe Asp 
                485                 490                 495     


Glu Phe Phe Ser Glu Gly Cys Ala Pro Gly Ser Lys Lys Asp Ser Ser 
            500                 505                 510         


Leu Cys Lys Leu Cys Met Gly Ser Gly Leu Asn Leu Cys Glu Pro Asn 
        515                 520                 525             


Asn Lys Glu Gly Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Val 
    530                 535                 540                 


Glu Lys Gly Asp Val Ala Phe Val Lys His Gln Thr Val Pro Gln Asn 
545                 550                 555                 560 


Thr Gly Gly Lys Asn Pro Asp Pro Trp Ala Lys Asn Leu Asn Glu Lys 
                565                 570                 575     


Asp Tyr Glu Leu Leu Cys Leu Asp Gly Thr Arg Lys Pro Val Glu Glu 
            580                 585                 590         


Tyr Ala Asn Cys His Leu Ala Arg Ala Pro Asn His Ala Val Val Thr 
        595                 600                 605             


Arg Lys Asp Lys Glu Ala Cys Val His Lys Ile Leu Arg Gln Gln Gln 
    610                 615                 620                 


His Leu Phe Gly Ser Asn Val Thr Asp Cys Ser Gly Asn Phe Cys Leu 
625                 630                 635                 640 


Phe Arg Ser Glu Thr Lys Asp Leu Leu Phe Arg Asp Asp Thr Val Cys 
                645                 650                 655     


Leu Ala Lys Leu His Asp Arg Asn Thr Tyr Glu Lys Tyr Leu Gly Glu 
            660                 665                 670         


Glu Tyr Val Lys Ala Val Gly Asn Leu Arg Lys Cys Ser Thr Ser Ser 
        675                 680                 685             


Leu Leu Glu Ala Cys Thr Phe Arg Arg Pro 
    690                 695             


<210>  18
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker 1


<220>
<221>  REPEAT
<222>  (1)..(6)
<223>  (PEAPTD)m, m=1, 2, 3, 4, or 5

<400>  18

Pro Glu Ala Pro Thr Asp 
1               5       


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker 2


<220>
<221>  repeat
<222>  (1)..(7)
<223>  (PEAPTDE)n, n=1, 2, 3, 4, or 5

<400>  19

Pro Glu Ala Pro Thr Asp Glu 
1               5           


<210>  20
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VH CDR1

<400>  20

Asp Thr Tyr Met His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VH CDR2

<400>  21

Arg Ile Asp Pro Ala Asn Gly Asp Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VH CDR3

<400>  22

Pro Arg Leu Val Arg Phe Pro Tyr Val Met Asp Tyr 
1               5                   10          


<210>  23
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VL CDR1

<400>  23

Arg Ala Ser Glu Asn Val Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VL CDR2

<400>  24

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VL CDR3

<400>  25

Gln His His Tyr Gly Phe Pro Tyr Thr 
1               5                   


<210>  26
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VH CDR1

<400>  26

Ser Ser Tyr Ile Ser 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VH CDR2

<400>  27

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VH CDR3

<400>  28

His Glu Gly Lys Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VL CDR1

<400>  29

Ser Ala Ser Ser Ser Val Ser Tyr Val His 
1               5                   10  


<210>  30
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VL CDR2

<400>  30

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VL CDR3

<400>  31

His Gln Arg Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  32
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VH CDR1

<400>  32

Asp Thr Tyr Met His 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VH CDR2

<400>  33

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VH CDR3

<400>  34

Gly Leu Gly Arg Trp Phe Ala Tyr 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VL CDR1

<400>  35

Lys Ala Ser Gln Asp Val Ser Asn Ala Val Ala 
1               5                   10      


<210>  36
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VL CDR2

<400>  36

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VL CDR3

<400>  37

Gln Gln His Asp Ser Thr Pro Leu Thr 
1               5                   


<210>  38
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VH CDR1

<400>  38

Gly Tyr Thr Met Asn 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VH CDR2

<400>  39

Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  40
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VH CDR3

<400>  40

Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr 
1               5                   10          


<210>  41
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VL CDR1

<400>  41

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VL CDR2

<400>  42

Tyr Thr Ser Lys Leu His Ser 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VL CDR3

<400>  43

Gln Gln Gly Asp Ala Leu Pro Trp Thr 
1               5                   


<210>  44
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VH CDR1

<400>  44

Ser Gly Tyr Trp Asn 
1               5   


<210>  45
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VH CDR2

<400>  45

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Cys Ile Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  46
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VH CDR3

<400>  46

Gly Asn Trp Gly Arg Glu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VL CDR1

<400>  47

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  48
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VL CDR2

<400>  48

Asn Val Lys Ile Leu Ala Glu 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VL CDR3

<400>  49

Gln His His Tyr Gly Leu Pro Tyr Thr 
1               5                   


<210>  50
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VH CDR1

<400>  50

Ser Thr Tyr Ile Ser 
1               5   


<210>  51
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VH CDR2

<400>  51

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VH CDR3

<400>  52

His Tyr Gly Thr Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  53
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VL CDR1

<400>  53

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  54
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VL CDR2

<400>  54

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VL CDR3

<400>  55

Leu Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  56
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VH CDR1

<400>  56

Ser Ser Thr Tyr Ile Ser 
1               5       


<210>  57
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VH CDR2

<400>  57

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VH CDR3

<400>  58

His Ile Gly Asn Tyr Trp Tyr Phe Asp Ile 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VL CDR1

<400>  59

Ser Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  60
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VL CDR2

<400>  60

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VL CDR3

<400>  61

His Gln Arg Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  62
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VH CDR1

<400>  62

Asp Tyr Trp Met His 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VH CDR2

<400>  63

Ala Val Asp Thr Ser Asp Arg Tyr Thr Thr Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VH CDR3

<400>  64

Gly Leu Thr Gly Pro Tyr Tyr Tyr Pro Met Asp Phe 
1               5                   10          


<210>  65
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VL CDR1

<400>  65

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  66
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VL CDR2

<400>  66

Ala Ala Thr Ser Leu Ala Asp 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VL CDR3

<400>  67

Gln Gln Val Phe Ser Ser Pro Tyr Thr 
1               5                   


<210>  68
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VH CDR1

<400>  68

Gly Tyr Thr Met Asn 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VH CDR2

<400>  69

Leu Ile Ile Pro His Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  70
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VH CDR3

<400>  70

Leu Met Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr 
1               5                   10          


<210>  71
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VL CDR1

<400>  71

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VL CDR2

<400>  72

Ala Ala Thr Ser Leu Ala Asp 
1               5           


<210>  73
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VL CDR3

<400>  73

Gln Gln Leu Phe Ser Thr Pro Trp Thr 
1               5                   


<210>  74
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VH CDR1

<400>  74

Gly Tyr Thr Met Asn 
1               5   


<210>  75
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VH CDR2

<400>  75

Leu Ile Ile Pro Ser Asn Gly Gly Thr Asn Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  76
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VH CDR3

<400>  76

Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr 
1               5                   10          


<210>  77
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VL CDR1

<400>  77

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  78
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VL CDR2

<400>  78

Tyr Thr Ser Lys Leu His Ser 
1               5           


<210>  79
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VL CDR3

<400>  79

Gln Gln Gly Asp Ala Leu Pro Trp Thr 
1               5                   


<210>  80
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VH CDR1

<400>  80

Gly Tyr Thr Met Asn 
1               5   


<210>  81
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VH CDR2

<400>  81

Leu Ile Ile Pro His Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  82
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VH CDR3

<400>  82

Leu Met Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr 
1               5                   10          


<210>  83
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VL CDR1

<400>  83

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  84
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VL CDR2

<400>  84

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  85
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VL CDR3

<400>  85

Gln Gln Gly Ala Thr Leu Pro Trp Thr 
1               5                   


<210>  86
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VH CDR1

<400>  86

Ser Gly Tyr Trp Asn 
1               5   


<210>  87
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VH CDR2

<400>  87

Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr His Thr Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210>  88
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VH CDR3

<400>  88

Gly Asn Trp Gly Arg Glu Ala Trp Phe Pro Tyr 
1               5                   10      


<210>  89
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VL CDR1

<400>  89

Arg Ala Ser Glu Ser Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  90
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VL CDR2

<400>  90

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  91
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VL CDR3

<400>  91

Gln His His Tyr Gly Phe Pro Tyr Thr 
1               5                   


<210>  92
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VH CDR1

<400>  92

Ser Tyr Trp Met His 
1               5   


<210>  93
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VH CDR2

<400>  93

Met Ile Asp Pro Ser Asp Ser Glu Thr Lys Leu Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  94
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VH CDR3

<400>  94

Asp Tyr Arg Tyr Asp Val Gly Ala Met Asp Tyr 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VL CDR1

<400>  95

Arg Ala Ser Lys Ser Ile Ser Lys Phe Leu Ala 
1               5                   10      


<210>  96
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VL CDR2

<400>  96

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VL CDR3

<400>  97

Gln Gln His His Glu Tyr Pro Trp Thr 
1               5                   


<210>  98
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VH

<400>  98

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Arg Leu Val Arg Phe Pro Tyr Val Met Asp Tyr Cys Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  99
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VH

<400>  99

Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  100
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VH

<400>  100

Glu Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  101
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VH

<400>  101

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  102
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VH

<400>  102

Glu Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Val Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Cys Ile Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asn Trp Gly Arg Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  103
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VH

<400>  103

Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Thr 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Gly Thr Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  104
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VH

<400>  104

Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Thr 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ile Gly Asn Tyr Trp Tyr Phe Asp Ile Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  105
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VH

<400>  105

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Met Pro Gly Pro 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Val Asp Thr Ser Asp Arg Tyr Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Met Thr Val Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Thr Gly Pro Tyr Tyr Tyr Pro Met Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Ala Ser Ser 
        115                 120     


<210>  106
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VH

<400>  106

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro His Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Met Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  107
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VH

<400>  107

Glu Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro Ser Asn Gly Gly Thr Asn Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  108
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VH

<400>  108

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro His Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Met Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  109
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VH

<400>  109

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Tyr Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr His Thr Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Met 
65                  70                  75                  80  


Gln Leu Asp Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asn Trp Gly Arg Glu Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  110
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VH

<400>  110

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Lys Leu Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Arg Tyr Asp Val Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  111
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone A VL

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  112
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone B VL

<400>  112

Gln Ile Leu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Ile Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  113
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C VL

<400>  113

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Asp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  114
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone D VL

<400>  114

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  115
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone F VL

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Val Lys Ile Leu Ala Glu Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Gln Leu Glu Ile Lys 
            100                 105         


<210>  116
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone G VL

<400>  116

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Gly Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  117
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone H VL

<400>  117

Gln Ile Leu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Phe Leu Ile Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  118
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone J VL

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln Gln Val Phe Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  119
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone K VL

<400>  119

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Phe Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  120
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone L VL

<400>  120

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  121
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone N VL

<400>  121

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  122
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone P VL

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Tyr Gly Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone Y VL

<400>  123

Asp Val Gln Ile Thr Gln Ser Pro Ser Phe Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Leu Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His His Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  124
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  Dh VH-CDR graft

<400>  124

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  125
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  DhVL-CDR graft

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  126
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  DhVH1

<400>  126

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  DhVH2

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala His Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  128
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  DhVH3

<400>  128

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  129
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  DhVL1

<400>  129

Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  130
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  DhVL2

<400>  130

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  131
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVH1

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  132
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVH2

<400>  132

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  133
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVH3

<400>  133

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  134
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVH4

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  135
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVH5

<400>  135

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  136
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVH6

<400>  136

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL1

<400>  137

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  138
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL2

<400>  138

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  139
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL3

<400>  139

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  140
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL4

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  141
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL5

<400>  141

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  142
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL6

<400>  142

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  143
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL7

<400>  143

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  144
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  BhVL8

<400>  144

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  145
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  145

Pro Glu Ala Pro Thr Asp 
1               5       


<210>  146
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  146

Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp 
1               5                   10          


<210>  147
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  147

Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro 
1               5                   10                  15      


Thr Asp 
        


<210>  148
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  148

Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro 
1               5                   10                  15      


Thr Asp Pro Glu Ala Pro Thr Asp 
            20                  


<210>  149
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  149

Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro 
1               5                   10                  15      


Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp 
            20                  25                  30  


<210>  150
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  150

Pro Glu Ala Pro Thr Asp Glu 
1               5           


<210>  151
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  151

Pro Glu Ala Pro Thr Asp Glu Pro Glu Ala Pro Thr Asp Glu 
1               5                   10                  


<210>  152
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  152

Pro Glu Ala Pro Thr Asp Glu Pro Glu Ala Pro Thr Asp Glu Pro Glu 
1               5                   10                  15      


Ala Pro Thr Asp Glu 
            20      


<210>  153
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  153

Pro Glu Ala Pro Thr Asp Glu Pro Glu Ala Pro Thr Asp Glu Pro Glu 
1               5                   10                  15      


Ala Pro Thr Asp Glu Pro Glu Ala Pro Thr Asp Glu 
            20                  25              


<210>  154
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  Transferrin linker

<400>  154

Pro Glu Ala Pro Thr Asp Glu Pro Glu Ala Pro Thr Asp Glu Pro Glu 
1               5                   10                  15      


Ala Pro Thr Asp Glu Pro Glu Ala Pro Thr Asp Glu Pro Glu Ala Pro 
            20                  25                  30          


Thr Asp Glu 
        35  


<210>  155
<211>  594
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 1

<400>  155

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Ala Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala 
    450                 455                 460                 


Pro Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
465                 470                 475                 480 


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
                485                 490                 495     


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
            500                 505                 510         


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
        515                 520                 525             


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
    530                 535                 540                 


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
545                 550                 555                 560 


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
                565                 570                 575     


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
            580                 585                 590         


Phe Ser 
        


<210>  156
<211>  603
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 2

<400>  156

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Ala Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala 
    450                 455                 460                 


Pro Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
465                 470                 475                 480 


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
                485                 490                 495     


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
            500                 505                 510         


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
        515                 520                 525             


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
    530                 535                 540                 


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
545                 550                 555                 560 


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
                565                 570                 575     


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
            580                 585                 590         


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        595                 600             


<210>  157
<211>  588
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 3

<400>  157

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Ala Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Ile Pro Pro 
    450                 455                 460                 


His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
465                 470                 475                 480 


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
                485                 490                 495     


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
            500                 505                 510         


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
        515                 520                 525             


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
    530                 535                 540                 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
545                 550                 555                 560 


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
                565                 570                 575     


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
            580                 585             


<210>  158
<211>  600
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 4

<400>  158

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Ala Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala 
    450                 455                 460                 


Pro Thr Asp Pro Glu Ala Pro Thr Asp Ile Pro Pro His Val Gln Lys 
465                 470                 475                 480 


Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
                485                 490                 495     


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
            500                 505                 510         


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
        515                 520                 525             


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
    530                 535                 540                 


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
545                 550                 555                 560 


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
                565                 570                 575     


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
            580                 585                 590         


Cys Asn Asp Asn Ile Ile Phe Ser 
        595                 600 


<210>  159
<211>  596
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 5

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala His Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Ala Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro 
    450                 455                 460                 


Glu Ala Pro Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
465                 470                 475                 480 


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
                485                 490                 495     


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
            500                 505                 510         


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
        515                 520                 525             


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
    530                 535                 540                 


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
545                 550                 555                 560 


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
                565                 570                 575     


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
            580                 585                 590         


Ile Ile Phe Ser 
        595     


<210>  160
<211>  592
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 6

<400>  160

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Pro 
        435                 440                 445             


Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr 
    450                 455                 460                 


Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
465                 470                 475                 480 


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
                485                 490                 495     


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
            500                 505                 510         


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
        515                 520                 525             


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
    530                 535                 540                 


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
545                 550                 555                 560 


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
                565                 570                 575     


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
            580                 585                 590         


<210>  161
<211>  596
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 7

<400>  161

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro His Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Met Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Ala Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro 
    450                 455                 460                 


Glu Ala Pro Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
465                 470                 475                 480 


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
                485                 490                 495     


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
            500                 505                 510         


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
        515                 520                 525             


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
    530                 535                 540                 


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
545                 550                 555                 560 


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
                565                 570                 575     


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
            580                 585                 590         


Ile Ile Phe Ser 
        595     


<210>  162
<211>  213
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - light chain 1

<400>  162

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Phe Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  163
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - light chain 2

<400>  163

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  164
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - light chain: 3

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Asp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  165
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - light chain: 4

<400>  165

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  166
<211>  591
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 8

<400>  166

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Glu 
        435                 440                 445             


Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp 
    450                 455                 460                 


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
465                 470                 475                 480 


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
                485                 490                 495     


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
            500                 505                 510         


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
        515                 520                 525             


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
    530                 535                 540                 


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
545                 550                 555                 560 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
                565                 570                 575     


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
            580                 585                 590     


<210>  167
<211>  600
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 9

<400>  167

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Glu 
        435                 440                 445             


Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp 
    450                 455                 460                 


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
465                 470                 475                 480 


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
                485                 490                 495     


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
            500                 505                 510         


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
        515                 520                 525             


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
    530                 535                 540                 


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
545                 550                 555                 560 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
                565                 570                 575     


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
            580                 585                 590         


Glu Tyr Asn Thr Ser Asn Pro Asp 
        595                 600 


<210>  168
<211>  585
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 10

<400>  168

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Glu 
        435                 440                 445             


Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Ile Pro Pro His Val Gln 
    450                 455                 460                 


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
465                 470                 475                 480 


Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 
                485                 490                 495     


Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 
            500                 505                 510         


Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 
        515                 520                 525             


Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 
    530                 535                 540                 


Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
545                 550                 555                 560 


Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 
                565                 570                 575     


Glu Cys Asn Asp Asn Ile Ile Phe Ser 
            580                 585 


<210>  169
<211>  597
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 11

<400>  169

Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Ile Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gly Lys Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Glu 
        435                 440                 445             


Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp 
    450                 455                 460                 


Pro Glu Ala Pro Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn 
465                 470                 475                 480 


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
                485                 490                 495     


Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys 
            500                 505                 510         


Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln 
        515                 520                 525             


Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu 
    530                 535                 540                 


Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu 
545                 550                 555                 560 


Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro 
                565                 570                 575     


Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp 
            580                 585                 590         


Asn Ile Ile Phe Ser 
        595         


<210>  170
<211>  593
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 12

<400>  170

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala His Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ile Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ile Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala 
        435                 440                 445             


Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro 
    450                 455                 460                 


Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
465                 470                 475                 480 


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
                485                 490                 495     


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
            500                 505                 510         


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
        515                 520                 525             


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
    530                 535                 540                 


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
545                 550                 555                 560 


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
                565                 570                 575     


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
            580                 585                 590         


Ser 
    


<210>  171
<211>  589
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 13

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala Pro Glu Ala Pro 
        435                 440                 445             


Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Ile Pro 
    450                 455                 460                 


Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn 
465                 470                 475                 480 


Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg 
                485                 490                 495     


Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile 
            500                 505                 510         


Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg 
        515                 520                 525             


Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys 
    530                 535                 540                 


Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys 
545                 550                 555                 560 


Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser 
                565                 570                 575     


Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
            580                 585                 


<210>  172
<211>  593
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 14

<400>  172

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ile Pro His Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Met Thr Thr Ala Pro Arg Asp Ser Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Ala 
        435                 440                 445             


Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro Thr Asp Pro Glu Ala Pro 
    450                 455                 460                 


Thr Asp Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
465                 470                 475                 480 


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
                485                 490                 495     


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
            500                 505                 510         


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
        515                 520                 525             


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
    530                 535                 540                 


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
545                 550                 555                 560 


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
                565                 570                 575     


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
            580                 585                 590         


Ser 
    


<210>  173
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 heavy chain

<400>  173

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Ala 
                325         


<210>  174
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVH1

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  175
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVH2

<400>  175

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  176
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVH3

<400>  176

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  177
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVH4

<400>  177

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  178
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVH5

<400>  178

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Arg Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  179
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVL1

<400>  179

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Asp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  180
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVL2

<400>  180

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Asp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  181
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone C- ChVL3

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Asp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  182
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  182

Gly Gly Gly Gly Ser 
1               5   


<210>  183
<211>  1782
<212>  DNA
<213>  artificial sequence

<220>
<223>  Fusion protein - heavy chain 1

<400>  183
caaggtcaac tagtgcaaag tggtgcagaa gtgaagaagc ctggaagctc cgtgaaggtg       60

tcctgtaaga catccggatt caccttctcc agttcctata tctcctgggt gcggcaggcc      120

cctggccagg gactggagtg gatgggctgg atctacgccg gcacaggcgg cacctcctac      180

aaccagaaat tcaccggcag ggtaaccatt acagtggaca catctacctc caccgcctac      240

atggaactga gctctctgag atccgaggat accgctgtgt actactgcgc cagacacgag      300

ggcaagtact ggtatttcga cgtgtggggc cagggcacca ccgtgaccgt gtcttctgcc      360

tcgaccaagg gcccttctgt gttccctctg gccccctcct ccaagagcac atctggcgga      420

accgctgctc tgggatgtct ggtgaaggac tactttcctg agcctgtgac tgtttcttgg      480

aacagcggcg ccctgacctc cggagtgcat accttccctg ccgtgctgca gtcttccggt      540

ctgtatagcc tgtccagcgt ggtgaccgtg cctagcagct ctctgggcac acagacatat      600

atttgtaacg tgaatcacaa gccttctaac accaaggtgg acaagcgggt tgagcctaag      660

tcctgcgaca agacccacac gtgtcctcct tgccctgctc ctgagctgct cggaggccct      720

tctgtgtttc tgttcccacc aaaacccaag gacaccctga tgatctcccg gacccctgaa      780

gtgacctgcg tggtggtgga cgtgtctcac gaggaccccg aagtcaagtt caactggtac      840

gtggacggcg tggaagtgca caacgccaag accaagccca gagaagagca gtacaattct      900

acctacagag tggtctccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag      960

tacaagtgca aggtctccaa taaggccctg cctgctccta tcgagaagac catctctaag     1020

gccaaaggcc agcccaggga acctcaagtg tacacactgc ccccaagccg cgaggaaatg     1080

accaagaacc aggtgtccct gacatgtctc gtgaagggct tctaccctag cgacatcgcc     1140

gtggagtggg agtccaatgg ccagcccgag aacaactaca agaccacacc acctgtgctg     1200

gactccgatg gctccttctt cctgtactcc aagctgaccg tggataagtc tagatggcag     1260

cagggcaacg tgttcagctg ttctgtgatg cacgaggctc tgcacaacca ctacacccag     1320

aaatctctgt ccctgtctcc tggagctcct gaggctccaa ccgaccctga agcccctacc     1380

gacccagagg cccccaccga tatccctcct cacgtgcaga agtccgtgaa caacgacatg     1440

atcgtgaccg acaacaacgg cgccgttaag tttccccagc tgtgcaagtt ctgcgatgtg     1500

cggttctcta cctgtgataa tcagaagtcc tgcatgtcca actgctctat cacctccatc     1560

tgcgagaagc ctcaagaggt gtgtgtggct gtctggcgga agaacgatga gaacatcacc     1620

ctggaaacag tgtgccacga tcccaagctg ccttaccacg acttcatcct ggaagatgct     1680

gcctctccta agtgcatcat gaaagaaaag aaaaaacccg gcgagacatt cttcatgtgc     1740

tcctgctcct ctgacgagtg caacgacaac atcatcttct ct                        1782


<210>  184
<211>  1809
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 2

<400>  184
cagggacagc tggtgcagag cggcgccgag gtgaagaagc ctggctccag cgtgaaggtg       60

tcctgcaaga ccagcggctt taccttttcc tcctcctata tctcctgggt gcggcaggcc      120

cccggccagg gactggagtg gatgggatgg atctacgccg gcaccggcgg caccagctac      180

aaccagaagt ttaccggcag ggtgaccatc accgtggata ccagcacctc caccgcctat      240

atggagctgt cctccctgcg gtccgaggat accgctgtgt actactgtgc tcggcacgag      300

ggcaagtact ggtattttga cgtgtggggc cagggcacca ccgtgaccgt gagcagcgct      360

tccaccaagg gccctagcgt gtttcctctg gccccttcca gcaagtccac cagcggcggc      420

accgccgctc tgggatgtct ggtgaaggat tatttccccg agcccgtgac cgtgtcctgg      480

aacagcggcg ctctgaccag cggcgtgcac acctttcctg ctgtgctgca gagcagcggc      540

ctgtatagcc tgtccagcgt ggtgaccgtg cccagcagct ccctgggcac ccagacctat      600

atctgtaacg tgaatcacaa gccctccaat accaaggtgg acaagagggt ggagcctaag      660

agctgcgaca agacccacac ctgtccccct tgccctgctc ctgagctgct gggcggccct      720

tccgtgttcc tgtttccccc taagcccaag gacaccctga tgatctcccg gacccccgag      780

gtgacctgcg tggtggtgga cgtgtcccac gaggaccccg aggtgaagtt taactggtac      840

gtggacggcg tggaggtgca caacgccaag accaagccta gggaggagca gtacaacagc      900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgta aggtgagcaa caaggccctg cctgctccta tcgagaagac catcagcaag     1020

gctaagggcc agcctaggga gccccaggtg tataccctgc ctcccagcag ggaggagatg     1080

accaagaatc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgct     1140

gtggagtggg agagcaatgg ccagcccgag aacaattaca agaccacccc ccccgtgctg     1200

gattccgacg gctccttctt cctgtattcc aagctgaccg tggataagag caggtggcag     1260

cagggcaatg tgttctcctg ctccgtgatg cacgaggctc tgcacaatca ctatacccag     1320

aagagcctga gcctgtcccc tggcgccccc gaagctccta ccgatcctga ggctcccacc     1380

gaccctgagg ccccaaccga catccctccc cacgtgcaga agtccgtgaa caacgacatg     1440

atcgtgaccg ataataatgg cgccgtgaag tttcctcagc tgtgcaagtt ttgcgacgtg     1500

cggttttcca cctgtgacaa ccagaagtcc tgtatgagca actgtagcat cacctccatc     1560

tgtgagaagc cccaggaggt gtgcgtggcc gtgtggagga agaacgacga gaatatcacc     1620

ctggagaccg tgtgtcacga ccctaagctg ccttatcacg attttatcct ggaggatgct     1680

gccagcccta agtgtatcat gaaggagaag aagaagcctg gagagacctt ctttatgtgt     1740

agctgtagca gcgatgagtg caatgacaac atcatctttt ccgaggagta caacacctcc     1800

aaccctgac                                                             1809


<210>  185
<211>  1764
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 3

<400>  185
cagggacagc tggtgcagag cggcgctgag gtgaagaagc ctggcagctc cgtgaaggtg       60

tcctgcaaga ccagcggctt cacctttagc agcagctata tctcctgggt gcggcaggct      120

cccggccagg gattggagtg gatgggctgg atctacgctg gcaccggcgg caccagctat      180

aaccagaagt tcaccggccg ggtgaccatc accgtggata cctccacctc caccgcttat      240

atggagctgt ccagcctgcg gagcgaggac accgccgtgt actattgcgc ccggcacgag      300

ggcaagtact ggtactttga cgtgtggggc cagggcacca ccgtgaccgt gagcagcgcc      360

tccaccaagg gccccagcgt gttccctctg gctccctcct ccaagtccac cagcggcggc      420

accgccgctc tgggatgtct ggtgaaggac tatttccccg agcccgtgac cgtgtcctgg      480

aactccggcg ccctgaccag cggcgtgcac acattccctg ctgtgctgca gagcagcggc      540

ctgtattccc tgtccagcgt ggtgaccgtg cctagctcct ccctgggcac ccagacctat      600

atctgcaacg tgaatcacaa gccttccaat accaaggtgg ataagcgggt ggagcctaag      660

agctgtgata agacccacac ctgccctcct tgccccgccc cagagctgct gggaggacct      720

agcgtgtttc tgtttccccc taagcctaag gacaccctga tgatcagcag gacccccgag      780

gtgacctgtg tggtggtgga cgtgtcccac gaggaccctg aggtgaagtt taactggtat      840

gtggacggcg tggaggtgca caatgccaag accaagcccc gggaggagca gtataattcc      900

acctataggg tggtgagcgt gctgaccgtg ctgcaccagg attggctgaa cggcaaggag      960

tacaagtgta aggtgtccaa caaggctctg cccgccccca tcgagaagac catctccaag     1020

gctaagggcc agcccaggga gccccaggtg tataccctgc ctccctccag ggaggagatg     1080

accaagaacc aggtgtccct gacctgcctg gtgaagggct tttatccttc cgacatcgcc     1140

gtggagtggg agtccaacgg ccagcccgag aataactata agaccacccc tcccgtgctg     1200

gacagcgatg gcagcttctt tctgtacagc aagctgaccg tggacaagag ccggtggcag     1260

cagggcaatg tgttctcctg cagcgtgatg cacgaggctc tgcacaacca ctatacccag     1320

aagtccctgt ccctgagccc cggcgcccct gaagctccaa ccgatcccga ggcccccacc     1380

gatatccctc ctcacgtgca gaagagcgtg aacaacgata tgatcgtgac cgataataat     1440

ggcgccgtga agttccctca gctgtgtaag ttttgtgacg tgaggttcag cacctgcgat     1500

aaccagaaga gctgtatgtc caattgcagc atcaccagca tctgcgagaa gccccaggag     1560

gtgtgcgtgg ccgtgtggag gaagaacgat gagaacatca ccctggagac cgtgtgtcac     1620

gaccccaagc tgccttacca cgattttatc ctggaggatg ctgcttcccc caagtgcatc     1680

atgaaggaga agaagaagcc cggcgagacc ttcttcatgt gcagctgcag cagcgacgag     1740

tgcaatgata atatcatctt ttcc                                            1764


<210>  186
<211>  1800
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 4

<400>  186
cagggacagc tggtgcagag cggcgctgag gtgaagaagc ccggctccag cgtgaaggtg       60

tcctgcaaga cctccggctt caccttctcc tccagctata tctcctgggt gcggcaggcc      120

cccggccagg gactggagtg gatgggatgg atctacgctg gcaccggcgg cacctcctac      180

aaccagaagt tcaccggcag ggtgaccatc accgtggata cctccaccag caccgcttat      240

atggagctgt cctccctgcg gtccgaggat accgccgtgt actactgcgc ccggcacgag      300

ggcaagtatt ggtactttga cgtgtggggc cagggcacca ccgtgaccgt gagcagcgct      360

agcaccaagg gcccttccgt gttccccctg gctccctcca gcaagagcac cagcggcggc      420

accgctgctc tgggatgcct ggtgaaggac tatttccctg agcctgtgac cgtgtcctgg      480

aacagcggcg ctctgaccag cggcgtgcac accttccctg ccgtgctgca gtccagcggc      540

ctgtattccc tgagcagcgt ggtgaccgtg ccttccagct ccctgggcac ccagacctac      600

atctgtaacg tgaaccacaa gcctagcaac accaaggtgg acaagcgggt ggagcccaag      660

tcctgtgata agacccacac ctgccctccc tgtcctgctc ctgagctgct gggcggcccc      720

tctgtgtttc tgtttcctcc caagcctaag gataccctga tgatctccag gacccccgag      780

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aggtgaagtt taattggtat      840

gtggacggcg tggaggtgca caacgctaag accaagccca gggaggagca gtacaactcc      900

acctataggg tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa tggcaaggag      960

tacaagtgca aggtgagcaa caaggccctg cccgctccta tcgagaagac catctccaag     1020

gctaagggcc agccccggga gcctcaggtg tataccctgc cccctagccg ggaggagatg     1080

accaagaatc aggtgtccct gacctgtctg gtgaagggct tctatccctc cgatatcgct     1140

gtggagtggg agagcaacgg ccagcccgag aataactata agaccacccc tcccgtgctg     1200

gatagcgacg gctccttttt cctgtatagc aagctgaccg tggataagag caggtggcag     1260

cagggcaacg tgtttagctg ctccgtgatg cacgaggctc tgcacaacca ctacacccag     1320

aagagcctgt ccctgtcccc cggcgctcct gaggctccta ccgaccctga ggcccctacc     1380

gatcctgagg ctcccaccga tcccgaggcc cctacagaca tccctcccca cgtgcagaag     1440

tccgtgaata acgatatgat cgtgaccgac aacaacggcg ctgtgaagtt tccccagctg     1500

tgcaagtttt gcgacgtgcg gttcagcacc tgcgataacc agaagagctg tatgagcaat     1560

tgctccatca cctccatctg cgagaagcct caggaggtgt gtgtggccgt gtggcggaag     1620

aacgacgaga acatcaccct ggagaccgtg tgccacgacc ccaagctgcc ttatcacgat     1680

ttcatcctgg aggacgccgc cagccccaag tgtatcatga aggagaagaa gaagcctggc     1740

gagacctttt tcatgtgcag ctgctcctcc gatgagtgca atgataacat catcttctcc     1800


<210>  187
<211>  1788
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 5

<400>  187
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ccggcgcttc cgtgaaggtg       60

tcctgtaagg ccagcggcta cagcttcacc ggctacacca tgaactgggt gaagcaggct      120

cacggccagg gcctggagtg gatgggcctg atcatccctt acaacggcgg catcagctat      180

aatcagaagt tcaaggaccg ggtgaccatg accgtggata ccagcatcag caccgcctac      240

atggagctgt ccaggctgcg gagcgatgat accgctgtgt attactgcgc cagcctgatc      300

accaccgctc ctagggatag catggactat tggggccagg gcaccctggt gaccgtgtcc      360

agcgcttcca ccaagggccc ttccgtgttc cctctggctc cttccagcaa gagcacctcc      420

ggcggcaccg ccgctctggg atgtctggtg aaggattatt tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gacctccggc gtgcacacat tccctgccgt gctgcagagc      540

agcggcctgt acagcctgtc cagcgtggtg accgtgccct ccagcagcct gggcacccag      600

acctatatct gcaatgtgaa tcacaagcct agcaacacca aggtggacaa gagggtggag      660

cctaagtcct gcgataagac ccacacctgt cctccttgcc ccgcccctga gctgctggga      720

ggaccttccg tgtttctgtt ccctcccaag cctaaggata ccctgatgat cagccggacc      780

cctgaggtga cctgcgtggt ggtggatgtg agccacgagg accctgaggt gaagttcaac      840

tggtacgtgg atggcgtgga ggtgcacaat gccaagacca agcccaggga ggagcagtac      900

aacagcacct atagggtggt gagcgtgctg accgtgctgc accaggattg gctgaacggc      960

aaggagtata agtgcaaggt gtccaacaag gctctgcccg ctcctatcga gaagaccatc     1020

tccaaggcta agggccagcc tcgggagcct caggtgtata ccctgcctcc tagccgggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta tcctagcgac     1140

atcgctgtgg agtgggagtc caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggata gcgatggctc cttcttcctg tatagcaagc tgaccgtgga caagagccgg     1260

tggcagcagg gcaacgtgtt ctcctgtagc gtgatgcacg aggccctgca caaccactat     1320

acccagaagt ccctgtccct gtcccctggc gcccctgagg ctccaaccga tcctgaggcc     1380

cccaccgacc ctgaggcccc aacagacatc ccccctcacg tgcagaagtc cgtgaacaac     1440

gacatgatcg tgaccgataa caacggcgct gtgaagttcc ctcagctgtg caagttttgc     1500

gatgtgaggt tcagcacctg cgacaatcag aagagctgca tgagcaactg cagcatcacc     1560

tccatctgtg agaagcccca ggaggtgtgc gtggctgtgt ggcggaagaa cgatgagaac     1620

atcaccctgg agaccgtgtg tcacgaccct aagctgcctt atcacgattt tatcctggag     1680

gacgccgcct cccccaagtg tatcatgaag gagaagaaga agcctggcga gaccttcttc     1740

atgtgttcct gcagcagcga tgagtgcaat gataatatca tcttcagc                  1788


<210>  188
<211>  1776
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 6

<400>  188
caggtgcagc tggtgcagtc cggcgctgag gtgaagaagc ctggcgccag cgtgaaggtg       60

tcctgtaagg cttccggctt caacatcaag gacacctata tgcactgggt gcggcaggct      120

cccggccagg gattggagtg gatcggccgg atcgatcctg ccaacggcaa caccaagtat      180

gatcccaagt tccagggccg ggtgaccatc accaccgaca ccagcgccag caccgcttac      240

ctggagctga gcagcctgcg gtccgaggat accgccgtgt attactgtgc caggggcctg      300

ggcaggtggt ttgcctattg gggccagggc accaccgtga ccgtgtccag cgctagcacc      360

aagggcccct ccgtgttccc tctggctcct tccagcaagt ccaccagcgg cggcaccgcc      420

gctctgggat gtctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaactcc      480

ggcgccctga cctccggcgt gcacacattt cctgccgtgc tgcagagcag cggcctgtat      540

tccctgagca gcgtggtgac cgtgcctagc tccagcctgg gcacccagac ctacatctgc      600

aacgtgaatc acaagccctc caacaccaag gtggataagc gggtggagcc caagtcctgt      660

gacaagaccc acacctgccc cccttgtccc gctcctgagc tgctgggcgg cccttctgtg      720

tttctgttcc cccctaagcc taaggacacc ctgatgatct cccggacccc tgaggtgacc      780

tgcgtggtgg tggacgtgtc ccacgaggac cctgaggtga agtttaattg gtacgtggat      840

ggcgtggagg tgcacaacgc taagaccaag cctagggagg agcagtataa tagcacctat      900

cgggtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtgt ccaataaggc cctgcctgct cctatcgaga agaccatcag caaggctaag     1020

ggccagccca gggagcccca ggtgtatacc ctgccccctt cccgggagga gatgaccaag     1080

aaccaggtga gcctgacctg tctggtgaaa ggcttttacc ccagcgatat cgccgtggag     1140

tgggagagca atggccagcc tgagaacaat tataagacca ccccccctgt gctggacagc     1200

gatggctcct ttttcctgta cagcaagctg accgtggata agagcaggtg gcagcagggc     1260

aatgtgttct cctgttccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc     1320

ctgtccctga gccccggcgc cccagaagct cctaccgacc cagaggcccc taccgacccc     1380

gaggctccaa ccgacatccc tcctcacgtg cagaagtccg tgaacaacga catgatcgtg     1440

accgataata atggcgccgt gaagtttcct cagctgtgca agttctgtga tgtgcggttt     1500

agcacctgcg ataaccagaa gtcctgtatg tccaattgct ccatcaccag catctgcgag     1560

aagccccagg aggtgtgcgt ggctgtgtgg cggaagaatg atgagaatat caccctggag     1620

accgtgtgcc acgaccccaa gctgccctat cacgacttca tcctggagga tgctgccagc     1680

cccaagtgca tcatgaagga gaagaagaag cctggagaga ccttcttcat gtgtagctgc     1740

agcagcgatg agtgcaatga taatatcatc ttcagc                               1776


<210>  189
<211>  1788
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 7

<400>  189
gaggtgcagc tgcagcagtc cggccccgag ctggtgaagc ccggagctag catgaagatc       60

agctgcaagg cctccggcta cagctttacc ggctacacca tgaactgggt gaagcagagc      120

cacggcaaga acctggagtg gatcggcctg atcatccctc acaatggcgg caccagctac      180

aatcagaagt tcaaggataa ggccaccctg accgtggaca agtccagcag gaccgcctac      240

atggagctgc tgtccctgac cagcgaggac agcgccgtgt actactgcgc cagcctgatg      300

accaccgccc ccagggacag catggattat tggggccagg gcaccagcgt gaccgtgtcc      360

agcgctagca ccaagggccc ttccgtgttc cctctggccc cttccagcaa gtccaccagc      420

ggcggcaccg ctgctctggg atgcctggtg aaggattact tccccgagcc cgtgaccgtg      480

tcttggaata gcggcgctct gacctccggc gtgcacacct ttcctgccgt gctgcagtcc      540

tccggcctgt attccctgag cagcgtggtg accgtgccca gcagctccct gggcacccag      600

acctatatct gcaatgtgaa ccacaagccc agcaatacca aggtggacaa gcgggtggag      660

cccaagtcct gcgacaagac ccacacctgc cccccctgtc ctgctcccga gctgctggga      720

ggccctagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagccggacc      780

cctgaggtga cctgtgtggt ggtggacgtg agccacgagg accctgaggt gaagtttaat      840

tggtacgtgg acggcgtgga ggtgcacaat gctaagacca agcccaggga ggagcagtac      900

aacagcacct atagggtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggagtata agtgtaaggt gtccaacaag gccctgcccg cccctatcga gaagaccatc     1020

agcaaggcta agggccagcc tcgggagccc caggtgtata ccctgcctcc ctcccgggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga aaggcttcta tccttccgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccctccc     1200

gtgctggata gcgacggctc cttctttctg tatagcaagc tgaccgtgga taagtccagg     1260

tggcagcagg gcaatgtgtt tagctgctcc gtgatgcacg aggccctgca caatcactac     1320

acccagaagt ccctgagcct gtcccctggc gcccccgaag ctccaaccga cccagaggcc     1380

cctaccgatc ctgaggcccc caccgatatc ccccctcacg tgcagaagag cgtgaacaat     1440

gacatgatcg tgaccgacaa caacggcgcc gtgaagttcc ctcagctgtg caagttttgc     1500

gatgtgcggt tctccacctg cgacaaccag aagagctgca tgtccaactg ctccatcacc     1560

tccatctgtg agaagcctca ggaggtgtgt gtggctgtgt ggaggaagaa cgacgagaac     1620

atcaccctgg agaccgtgtg tcacgatcct aagctgcctt accacgactt tatcctggag     1680

gacgccgcta gccccaagtg catcatgaag gagaagaaga agcctggcga gaccttcttt     1740

atgtgctcct gcagcagcga cgagtgcaat gacaatatca tcttcagc                  1788


<210>  190
<211>  639
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - light chain 1

<400>  190
gagatcgtga tgacccagag ccccgccacc ctgtccgtgt ccccaggaga gcgggccacc       60

ctgtcttgta gcgcttctag ctccgtgagc tatgtgcact ggtatcaaca gaagcccggc      120

caggctccca ggccctggat ctatgatacc agcaatctgg cctccggctt ccccgctagg      180

ttctccggct ccggcagcgg aaccgagtat accctgacca tctcctccct gcagtccgag      240

gacgccgctg tgtattattg ccaccagagg agctcctatc cctggacctt cggcggcggc      300

accaaggtgg agatcaagag gaccgtggcc gctccctccg tgttcatctt ccccccctcc      360

gatgagcagc tgaagagcgg caccgccagc gtggtgtgcc tgctgaacaa cttctaccct      420

agggaggcta aggtgcagtg gaaggtggac aacgctctgc agtccggcaa tagccaggag      480

agcgtgaccg agcaggatag caaggacagc acctattccc tgtcctccac cctgaccctg      540

tccaaggctg actacgagaa gcacaaggtg tacgcttgtg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagtc ctttaatcgg ggcgagtgt                             639


<210>  191
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - light chain 2

<400>  191
gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggctagcca ggatatcagc aattacctga actggtatca acagaagccc      120

ggcaaggctc ctaagctgct gatctactac accagcaagc tgcactccgg cgtgcctagc      180

aggtttagcg gctccggctc cggcaccgat tttaccctga ccatcagcag cctgcagcct      240

gaggatatcg ctacctatta ctgccagcag ggcgatgccc tgccttggac ctttggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgctcctt ccgtgtttat cttcccccct      360

agcgacgagc agctgaagag cggcaccgct tccgtggtgt gtctgctgaa taacttttac      420

cctcgggagg ctaaggtgca gtggaaggtg gacaacgctc tgcagagcgg caactcccag      480

gagagcgtga ccgagcagga ctccaaggac agcacctact ccctgtccag caccctgacc      540

ctgagcaagg ccgattacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtcctccc ccgtgaccaa gtcctttaat aggggcgagt gc                         642


<210>  192
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - light chain 3

<400>  192
gacatccaga tgacccagtc ccccagcagc ctgagcgctt ccgtgggcga ccgggtgacc       60

atcacctgcc aggcctccca ggatgtgagc aatgctgtgg cctggtatca acagaagccc      120

ggcaaggccc ctaagctgct gatctatagc gctagcaacc tgtacaccgg cgtgcccagc      180

aggttcagcg gcagcggatc tggcaccgat tttaccttca ccatcagcag cctgcagccc      240

gaggacatcg ctacctacta ctgccagcag cacgacagca cccccctgac cttcggccag      300

ggcaccaagc tggagctgaa gaggaccgtg gccgccccca gcgtgttcat cttcccccct      360

tccgacgagc agctgaagag cggcaccgct agcgtggtgt gcctgctgaa taatttttac      420

cctagggagg ctaaggtgca gtggaaggtg gacaacgctc tgcagagcgg caatagccag      480

gagtccgtga ccgagcagga cagcaaggac agcacctata gcctgagcag caccctgacc      540

ctgtccaagg ccgactatga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ctgtgaccaa gtccttcaat cggggcgagt gc                         642


<210>  193
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - light chain 4

<400>  193
gatatccaga tgacccagac cacctcctcc ctgtccgcca gcctgggcga tagggtgacc       60

atctcctgca gggccagcca ggatatctcc aactatctga actggtatca acagaagcct      120

gatggcaccg tgaagctgct gatctactac accagccggc tgcactccgg cgtgccctct      180

aggttcagcg gcagcggcag cggaaccgac tatagcctga ccatcagcaa cctggatcag      240

gaggacatcg ctacctactt ctgtcagcag ggcgccaccc tgccctggac ctttggcgga      300

ggcaccaagc tggagatcaa gcggaccgtg gctgctccca gcgtgttcat cttccctcct      360

tccgatgagc agctgaagtc cggcaccgcc tccgtggtgt gtctgctgaa caacttctat      420

cctagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caactcccag      480

gagagcgtga ccgagcagga tagcaaggat agcacctatt ccctgtccag caccctgacc      540

ctgtccaagg ctgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ctgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  194
<211>  1773
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 8

<400>  194
cagggacagc tggtgcagag cggcgccgag gtgaagaagc ctggcagcag cgtgaaggtg       60

tcctgcaaga cctccggctt tacctttagc tcctcctata tctcctgggt gcggcaggct      120

cccggccagg gattggagtg gatgggctgg atctacgccg gcaccggcgg cacatcctac      180

aaccagaagt ttaccggccg ggtgaccatc accgtggaca ccagcacctc caccgcttat      240

atggagctgt ccagcctgcg gtccgaggat accgctgtgt actactgcgc ccggcacgag      300

ggcaagtact ggtactttga tgtgtggggc cagggcacca ccgtgaccgt gtcctccgcc      360

tccaccaagg gccctagcgt gtttcctctg gctccctgta gcaggagcac ctccgagagc      420

accgccgccc tgggatgtct ggtgaaggat tattttcccg agcctgtgac cgtgagctgg      480

aatagcggcg ctctgaccag cggcgtgcac acctttcctg ctgtgctgca gagcagcggc      540

ctgtattccc tgtcctccgt ggtgaccgtg cctagctcct ccctgggcac caagacctac      600

acctgcaacg tggatcacaa gccttccaat accaaggtgg acaagcgggt ggagagcaag      660

tacggccccc cctgtccccc ttgtcccgct cctgagtttc tgggcggccc ttccgtgttc      720

ctgtttcccc ccaagcctaa ggacaccctg atgatctccc ggacccctga ggtgacctgc      780

gtggtggtgg atgtgtccca ggaggaccct gaggtgcagt tcaactggta tgtggacggc      840

gtggaggtgc acaacgctaa gaccaagcct cgggaggagc agttcaactc cacctacagg      900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga atggcaagga gtataagtgt      960

aaggtgtcca ataagggcct gccttcctcc atcgagaaga ccatcagcaa ggctaagggc     1020

cagcccaggg agccccaggt gtataccctg cctcccagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaagggc ttctacccct ccgatatcgc cgtggagtgg     1140

gagtccaacg gccagcctga gaacaactac aagaccaccc ctcctgtgct ggactccgac     1200

ggctcctttt tcctgtacag ccggctgacc gtggataaga gcaggtggca ggagggcaat     1260

gtgttcagct gttccgtgat gcacgaggct ctgcacaacc actacaccca gaagagcctg     1320

agcctgtccc tgggcgcccc tgaggctcct accgatcccg aggctcccac cgatcccgaa     1380

gctcccaccg acatcccccc tcacgtgcag aagtccgtga acaacgatat gatcgtgacc     1440

gataacaatg gcgccgtgaa gtttccccag ctgtgtaagt tctgcgatgt gaggtttagc     1500

acctgtgaca atcagaagag ctgcatgagc aactgctcca tcaccagcat ctgtgagaag     1560

ccccaggagg tgtgtgtggc tgtgtggagg aagaacgatg agaacatcac cctggagacc     1620

gtgtgccacg atcccaagct gccctaccac gatttcatcc tggaggatgc tgccagccct     1680

aagtgtatca tgaaggagaa gaagaagcct ggagagacct tcttcatgtg cagctgctcc     1740

agcgacgagt gcaacgataa catcatcttc tcc                                  1773


<210>  195
<211>  1800
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 9

<400>  195
cagggacagc tggtgcagag cggcgctgag gtgaagaagc ctggcagcag cgtgaaggtg       60

tcctgtaaga cctccggctt cacctttagc tccagctaca tcagctgggt gcggcaggcc      120

cctggccagg gattggagtg gatgggctgg atctacgctg gcaccggcgg cacctcctac      180

aaccagaagt tcaccggcag ggtgaccatc accgtggata cctccacctc caccgcttac      240

atggagctga gcagcctgcg gtccgaggac accgccgtgt attactgtgc tcggcacgag      300

ggcaagtact ggtatttcga tgtgtggggc cagggcacca ccgtgaccgt gtcctccgct      360

tccaccaagg gcccctccgt gtttcctctg gccccttgct cccggtccac cagcgagtcc      420

accgccgctc tgggctgtct ggtgaaggat tattttcctg agcctgtgac cgtgtcttgg      480

aacagcggcg ctctgacctc cggcgtgcac accttccctg ccgtgctgca gagcagcggc      540

ctgtacagcc tgtccagcgt ggtgaccgtg cctagctcct ccctgggcac caagacctat      600

acctgcaacg tggatcacaa gccttccaac accaaggtgg ataagagggt ggagagcaag      660

tacggccccc cttgtccccc ttgtccagct cctgagttcc tgggcggccc ctccgtcttt      720

ctgttccctc ccaagcctaa ggataccctg atgatctcca ggacccctga ggtgacctgt      780

gtggtggtgg atgtgagcca ggaggaccct gaggtgcagt tcaactggta cgtggacggc      840

gtggaggtgc acaatgccaa gaccaagcct agggaggagc agtttaatag cacctacagg      900

gtggtgagcg tgctgaccgt gctgcaccag gattggctga acggcaagga gtataagtgt      960

aaggtgagca ataagggcct gccctccagc atcgagaaga ccatctccaa ggctaagggc     1020

cagccccggg agccccaggt ttataccctg ccccccagcc aggaggagat gaccaagaat     1080

caggtgagcc tgacctgcct ggtgaagggc ttttatccct ccgacatcgc tgtggagtgg     1140

gagagcaacg gccagcctga gaacaactac aagaccaccc ctcctgtgct ggacagcgac     1200

ggcagctttt tcctgtacag ccggctgacc gtggacaagt cccggtggca ggagggcaat     1260

gtgtttagct gctccgtgat gcacgaggcc ctgcacaatc actataccca gaagtccctg     1320

agcctgtccc tgggcgctcc tgaggcccca accgaccctg aggctcccac cgatcccgag     1380

gcccctaccg acatcccccc tcacgtgcag aagtccgtga acaatgacat gatcgtgacc     1440

gacaacaatg gcgctgtgaa gtttccccag ctgtgcaagt tctgcgacgt gaggttttcc     1500

acctgtgaca atcagaagtc ctgtatgtcc aattgcagca tcacctccat ctgcgagaag     1560

ccccaggagg tgtgcgtggc tgtgtggagg aagaatgatg agaatatcac cctggagacc     1620

gtgtgtcacg atcctaagct gccttatcac gattttatcc tggaggatgc cgccagcccc     1680

aagtgcatca tgaaggagaa gaagaagccc ggcgagacct ttttcatgtg cagctgttcc     1740

agcgacgagt gcaatgataa catcatcttc agcgaggagt ataacacctc caaccctgac     1800


<210>  196
<211>  1755
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 10

<400>  196
cagggacagc tggtgcagtc cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

tcctgcaaga ccagcggctt tacctttagc tccagctaca tcagctgggt gaggcaggct      120

cccggccagg gactggagtg gatgggctgg atctatgctg gcaccggcgg cacctcctac      180

aatcagaagt ttaccggccg ggtgaccatc accgtggaca ccagcacctc caccgcttac      240

atggagctgt cctccctgcg gtccgaggat accgccgtgt actactgtgc ccggcacgag      300

ggcaagtact ggtactttga cgtgtggggc cagggcacca ccgtgaccgt gtcctccgcc      360

agcaccaagg gcccttccgt gtttcccctg gctccttgca gccggtccac ctccgagagc      420

accgccgctc tgggctgtct ggtgaaggac tacttccctg agcccgtgac cgtgagctgg      480

aatagcggcg ccctgacctc cggcgtgcac acatttcccg ctgtgctgca gagcagcggc      540

ctgtattccc tgtccagcgt ggtgaccgtg ccctcctcca gcctgggcac caagacctat      600

acctgcaacg tggaccacaa gccctccaat accaaggtgg ataagcgggt ggagtccaag      660

tatggccccc cttgcccccc ctgtcctgcc cctgaatttc tgggcggccc cagcgtgttc      720

ctgttccccc caaagcccaa ggacaccctg atgatctcca ggacccctga ggtgacctgc      780

gtggtggtgg atgtgagcca ggaggaccct gaggtgcagt tcaattggta tgtggacggc      840

gtggaggtgc acaatgccaa gaccaagcct cgggaggagc agttcaactc cacctacagg      900

gtggtgagcg tgctgaccgt gctgcaccag gattggctga atggcaagga gtataagtgc      960

aaggtgtcca acaagggcct gccttcctcc atcgagaaga ccatctccaa ggccaagggc     1020

cagccccggg agcctcaggt ttacaccctg ccccctagcc aggaggagat gaccaagaac     1080

caggtgagcc tgacctgcct ggtgaagggc ttttacccca gcgatatcgc cgtggagtgg     1140

gagtccaacg gccagcccga gaacaattac aagaccaccc ctcccgtgct ggactccgat     1200

ggcagctttt tcctgtacag ccggctgacc gtggacaagt cccggtggca ggagggcaac     1260

gtgttttcct gctccgtgat gcacgaggcc ctgcacaacc actataccca gaagagcctg     1320

tccctgtccc tgggcgctcc cgaggctcca accgacccag aggcccctac cgatatccct     1380

cctcacgtgc agaagagcgt gaacaacgat atgatcgtga ccgataataa tggcgccgtg     1440

aagttccctc agctgtgtaa gttttgcgac gtgaggttca gcacctgcga caatcagaag     1500

agctgtatga gcaattgtag catcacctcc atctgcgaga agccccagga ggtgtgcgtg     1560

gctgtgtggc ggaagaatga tgagaacatc accctggaga ccgtgtgcca cgatcccaag     1620

ctgccctacc acgattttat cctggaggat gctgcctccc ccaagtgcat catgaaggag     1680

aagaagaagc ccggagagac cttcttcatg tgcagctgta gctccgatga gtgtaatgac     1740

aatatcatct tttcc                                                      1755


<210>  197
<211>  1791
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 11

<400>  197
cagggacagc tggtgcagag cggcgccgag gtgaagaagc ctggctccag cgtgaaggtg       60

tcctgcaaga ccagcggctt caccttttcc agctcctaca tcagctgggt gcggcaggct      120

cccggccagg gattggagtg gatgggctgg atctatgccg gcaccggcgg caccagctac      180

aatcagaagt tcaccggccg ggtgaccatc accgtggaca cctccacctc caccgcctac      240

atggagctgt ccagcctgag gagcgaggat accgctgtgt actactgcgc caggcacgag      300

ggcaagtatt ggtatttcga cgtgtggggc cagggcacca ccgtgaccgt gtcctccgcc      360

tccaccaagg gcccctccgt gtttcccctg gccccctgta gcaggtccac cagcgagagc      420

accgccgctc tgggctgcct ggtgaaggac tacttccctg agcctgtgac cgtgagctgg      480

aactccggcg ccctgaccag cggcgtgcac acattccctg ccgtgctgca gagcagcggc      540

ctgtactccc tgagcagcgt ggtgaccgtg cctagcagct ccctgggcac caagacctat      600

acctgtaatg tggatcacaa gcctagcaat accaaggtgg acaagcgggt ggagtccaag      660

tacggccccc cttgcccccc ctgcccagct cctgaatttc tgggcggccc ttccgtgttc      720

ctgtttcctc ccaagcccaa ggacaccctg atgatcagcc ggacccctga ggtgacctgt      780

gtggtggtgg atgtgagcca ggaggaccct gaggtgcagt tcaattggta cgtggacggc      840

gtggaggtgc acaacgccaa gaccaagccc agggaggagc agttcaacag cacctacagg      900

gtggtgtccg tgctgaccgt gctgcaccag gattggctga atggcaagga gtacaagtgt      960

aaggtgagca ataagggcct gccttccagc atcgagaaga ccatcagcaa ggccaagggc     1020

cagcctaggg agccccaggt gtacaccctg ccccccagcc aggaggagat gaccaagaat     1080

caggtgagcc tgacctgtct ggtgaagggc ttctatccca gcgatatcgc tgtggagtgg     1140

gagagcaacg gccagcctga gaacaattac aagaccaccc ctcctgtgct ggattccgat     1200

ggctcctttt tcctgtactc ccggctgacc gtggataaga gccggtggca ggagggcaac     1260

gtgtttagct gtagcgtgat gcacgaggct ctgcacaacc actacaccca gaagagcctg     1320

agcctgagcc tcggcgcccc tgaggctcca accgacccag aggcccctac cgatcccgag     1380

gcccctacag atcctgaggc ccccaccgat atcccccccc acgtgcagaa gtccgtgaat     1440

aacgacatga tcgtgaccga taacaacggc gctgtgaagt tccctcagct gtgcaagttc     1500

tgtgatgtga ggtttagcac ctgtgacaac cagaagagct gcatgagcaa ctgctccatc     1560

acctccatct gcgagaagcc tcaggaggtg tgtgtggccg tgtggcggaa gaatgatgag     1620

aatatcaccc tggagaccgt gtgccacgac cccaagctgc cctaccacga cttcatcctg     1680

gaggatgctg ctagccccaa gtgtatcatg aaggagaaga agaagcctgg agagaccttc     1740

ttcatgtgta gctgcagctc cgatgagtgt aacgataata tcatcttctc c              1791


<210>  198
<211>  1779
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 12

<400>  198
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ccggcgcttc cgtgaaggtg       60

tcctgcaagg cttccggcta ctcctttacc ggctacacca tgaactgggt gaagcaggcc      120

cacggccagg gcctggagtg gatgggactg atcatcccct acaacggcgg catctcctac      180

aaccagaagt tcaaggatcg ggtgaccatg accgtggaca ccagcatcag caccgcttat      240

atggagctga gcaggctgcg gtccgacgac accgccgtgt actactgcgc ctccctgatc      300

accaccgccc ctcgggacag catggattac tggggccagg gcaccctggt gaccgtgagc      360

agcgccagca ccaagggccc ctccgtgttc cctctggccc cctgtagcag gtccaccagc      420

gagtccaccg ccgctctggg ctgcctggtg aaggactact ttcccgagcc cgtgaccgtg      480

tcttggaact ccggcgctct gacctccggc gtgcacacct ttcccgctgt gctgcagtcc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccta gctccagcct gggcaccaag      600

acctatacct gtaatgtgga ccacaagccc agcaacacca aggtggacaa gcgggtggag      660

agcaagtacg gccccccttg ccctccttgt cctgccccag agtttctggg cggccccagc      720

gtgtttctgt ttccccccaa gcctaaggac accctgatga tctcccggac ccctgaggtg      780

acctgcgtgg tggtggatgt gagccaggag gaccctgagg tgcagttcaa ttggtacgtg      840

gacggcgtgg aggtgcacaa tgctaagacc aagcctaggg aggagcagtt taactccacc      900

tatagggtgg tgagcgtgct gaccgtgctg caccaggatt ggctgaatgg caaggagtac      960

aagtgcaagg tgagcaacaa gggcctgccc tccagcatcg agaagaccat ctccaaggct     1020

aagggccagc ccagggagcc ccaggtgtac accctgcccc ccagccagga ggagatgacc     1080

aagaaccagg tgagcctgac ctgtctggtg aagggctttt atcctagcga tatcgctgtg     1140

gagtgggagt ccaacggcca gcccgagaac aactacaaga ccacccctcc tgtgctggat     1200

agcgatggca gcttcttcct gtacagccgg ctgaccgtgg ataagagcag gtggcaggag     1260

ggcaacgtgt tcagctgttc cgtgatgcac gaggctctgc acaaccacta cacccagaag     1320

tccctgtccc tgagcctggg cgcccctgag gctccaaccg atcctgaggc tcctaccgac     1380

cccgaggctc ctacagacat ccctcctcac gtgcagaagt ccgtgaataa cgacatgatc     1440

gtgaccgata acaacggcgc tgtgaagttc ccccagctgt gtaagttctg cgatgtgcgg     1500

ttcagcacct gtgacaatca gaagtcctgt atgtccaact gtagcatcac cagcatctgt     1560

gagaagcccc aggaggtgtg cgtggctgtg tggcggaaga atgacgagaa tatcaccctg     1620

gagaccgtgt gtcacgaccc taagctgccc tatcacgatt ttatcctgga ggacgccgcc     1680

tcccccaagt gcatcatgaa ggagaagaag aagcctggcg agaccttctt catgtgtagc     1740

tgctcctccg atgagtgcaa tgacaacatc atctttagc                            1779


<210>  199
<211>  1767
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 13

<400>  199
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ctggcgcttc cgtgaaggtg       60

agctgtaagg ctagcggctt caatatcaag gacacctata tgcactgggt gcggcaggcc      120

cctggccagg gattggagtg gatcggccgg atcgatcctg ctaatggcaa caccaagtat      180

gatcccaagt tccagggcag ggtgaccatc accaccgaca ccagcgcctc caccgcctat      240

ctggagctga gcagcctgcg gtccgaggac accgccgtgt attattgtgc tcggggcctg      300

ggcaggtggt tcgcctactg gggccagggc accaccgtga ccgtgagcag cgcttccacc      360

aagggcccct ccgtgttccc tctggctccc tgcagcaggt ccaccagcga gtccaccgcc      420

gccctgggat gtctggtgaa ggactacttt cccgagcccg tgaccgtgtc ttggaatagc      480

ggcgctctga ccagcggcgt gcacaccttt cccgccgtgc tgcagagcag cggcctgtac      540

tccctgtcca gcgtggtgac cgtgccctcc tccagcctgg gcaccaagac ctacacctgc      600

aacgtggacc acaagcctag caacaccaag gtggataagc gggtggagag caagtacggc      660

cctccttgtc ccccctgtcc cgctccagag ttcctgggcg gccctagcgt gttcctgttc      720

ccccccaagc ccaaggatac cctgatgatc agccggaccc ctgaggtgac ctgcgtggtg      780

gtggatgtga gccaggagga ccccgaggtg cagtttaatt ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gcctagggag gagcagttca atagcaccta cagggtggtg      900

agcgtgctga ccgtgctgca ccaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

agcaacaagg gcctgcctag ctccatcgag aagaccatca gcaaggctaa gggccagcct     1020

cgggagcccc aggtgtacac cctgcctcct agccaggagg agatgaccaa gaatcaggtg     1080

tccctgacct gtctggtgaa aggcttctat ccttccgata tcgctgtgga gtgggagagc     1140

aacggccagc ctgagaataa ttataagacc acccctcctg tgctggatag cgacggcagc     1200

tttttcctgt acagccggct gaccgtggac aagtcccggt ggcaggaggg caacgtgttt     1260

tcctgttccg tgatgcacga ggccctgcac aaccactaca cccagaagag cctgtccctg     1320

agcctgggcg ctcccgaggc tcctaccgat cctgaggccc ctaccgatcc cgaggctcca     1380

accgacatcc ccccccacgt gcagaagagc gtgaataatg acatgatcgt gaccgacaat     1440

aacggcgccg tgaagttccc tcagctgtgc aagttctgcg acgtgcggtt tagcacctgc     1500

gacaaccaga agagctgtat gtccaactgc tccatcacct ccatctgtga gaagccccag     1560

gaggtgtgcg tggccgtgtg gaggaagaat gatgagaata tcaccctgga gaccgtgtgt     1620

cacgacccca agctgcctta ccacgatttc atcctggagg acgctgctag ccctaagtgt     1680

atcatgaagg agaagaagaa gcctggagag accttcttta tgtgtagctg cagcagcgac     1740

gagtgcaatg acaacatcat cttctcc                                         1767


<210>  200
<211>  1779
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion protein - heavy chain 14

<400>  200
gaggtgcagc tgcagcagtc cggccccgag ctggtgaagc ccggagctag catgaagatc       60

tcctgcaagg cctccggcta ctcctttacc ggctacacca tgaattgggt gaagcagagc      120

cacggcaaga atctggagtg gatcggcctg atcatccctc acaatggcgg cacctcctac      180

aaccagaagt tcaaggacaa ggctaccctg accgtggaca agtcctccag gaccgcttat      240

atggagctgc tgtccctgac cagcgaggat agcgccgtgt actattgcgc ctccctgatg      300

accaccgccc ctagggacag catggactac tggggccagg gcacctccgt gaccgtgagc      360

agcgcctcca ccaagggccc cagcgtgttc cccctggctc cctgtagcag gtccacctcc      420

gagagcaccg ctgccctggg ctgtctggtg aaggactact ttcccgagcc cgtgaccgtg      480

tcctggaata gcggcgctct gacctccggc gtgcacacct tccccgccgt gctgcagtcc      540

agcggcctgt acagcctgtc cagcgtggtg accgtgcctt cctccagcct gggcaccaag      600

acctacacct gtaacgtgga ccacaagccc agcaatacca aggtggacaa gagggtggag      660

tccaagtatg gccccccctg tcctccctgc cccgctcctg aatttctggg cggcccctcc      720

gtgttcctgt ttccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      780

acctgtgtgg tggtggacgt gtcccaggag gaccccgagg tgcagttcaa ctggtacgtg      840

gacggcgtgg aggtgcacaa tgccaagacc aagcctcggg aggagcagtt caatagcacc      900

tatcgggtgg tgagcgtgct gaccgtgctg caccaggatt ggctgaacgg caaggagtac      960

aagtgcaagg tgtccaacaa gggcctgccc agctccatcg agaagaccat ctccaaggct     1020

aagggccagc cccgggagcc ccaggtttac accctgcctc ctagccagga ggagatgacc     1080

aagaaccagg tgtccctgac ctgtctggtg aaaggctttt atcctagcga tatcgccgtg     1140

gagtgggaga gcaatggcca gcccgagaac aattacaaga ccacccctcc tgtgctggac     1200

agcgatggca gcttctttct gtacagccgg ctgaccgtgg ataagagcag gtggcaggag     1260

ggcaacgtgt tctcctgtag cgtgatgcac gaggctctgc acaatcacta cacccagaag     1320

tccctgagcc tgtccctggg cgcccccgaa gctcctaccg atcccgaggc tcccaccgac     1380

cccgaggctc ctaccgacat cccccctcac gtgcagaagt ccgtgaacaa cgatatgatc     1440

gtgaccgata acaacggcgc tgtgaagttc ccccagctgt gtaagttctg tgacgtgagg     1500

ttttccacct gtgataacca gaagagctgt atgtccaatt gcagcatcac cagcatctgt     1560

gagaagcctc aggaggtgtg cgtggccgtg tggcggaaga acgatgagaa tatcaccctg     1620

gagaccgtgt gccacgaccc taagctgccc taccacgatt tcatcctgga ggatgctgcc     1680

agccctaagt gcatcatgaa ggagaagaag aagcctggcg agaccttttt catgtgcagc     1740

tgtagcagcg acgagtgtaa cgacaatatc atcttcagc                            1779


<210>  201
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-betaRII isoform 1ECD 1-136 N19T mutant

<400>  201

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Thr Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     


