                         SEQUENCE LISTING

<110>  Immunome Inc.
 
<120>  SNX9 Subfamily-Targeting Antibodies

<130>  172.0010-WO00

<150>  US 63/076,462
<151>  2020-09-10

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  1
ccctgtccct cacctgcgcg gcctacggtg gggcgttcgg taattactac tggagctggg       60

tccgccagtc cccagagaag ggacttgaat ggattgggga aataagtcat agtggaagta      120

ccaactacaa cccgtctctc aagagtcgag tcaccatgtc cgtcgacacg tctaagaccc      180

ggttctccct gaggttgagc tctgtcaacg ccgcggacac ggctatatat tactgtgcga      240

gaggtccctt tcgcccaaaa tttgttttgt atccaggtgc ctactggtac ttcaatctct      300

ggggccgtgg caccctggtc actgtctcct cagcttccac caagggccca tcggtcttcc      360

ccctggcac                                                              369


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Ser Leu Thr Cys Ala Ala Tyr Gly Gly Ala Phe Gly Asn Tyr Tyr 
1               5                   10                  15      


Trp Ser Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Gly 
            20                  25                  30          


Glu Ile Ser His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
        35                  40                  45              


Arg Val Thr Met Ser Val Asp Thr Ser Lys Thr Arg Phe Ser Leu Arg 
    50                  55                  60                  


Leu Ser Ser Val Asn Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
65                  70                  75                  80  


Gly Pro Phe Arg Pro Lys Phe Val Leu Tyr Pro Gly Ala Tyr Trp Tyr 
                85                  90                  95      


Phe Asn Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120         


<210>  3
<211>  311
<212>  DNA
<213>  Homo sapiens

<400>  3
agacagagtc accatcacct gccgggccag tcagagtatc agtaataggt tggcctggta       60

tcaacagaaa cctgggaaag cccctaacct cctgatctct gaggcgtcta ctttagaaga      120

tggggtccca tcaaggttca gcggcagtgg atatgggaca gaattcactc tcaacattaa      180

cggcctgcag cctgatgact ttgcaactta ttactgccaa gactattata gttattctag      240

gacttttggc caggggacca agctggagat caaacgaact gtggctgcac catcggtctt      300

ccccctggca c                                                           311


<210>  4
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Arg 
1               5                   10                  15      


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
            20                  25                  30          


Ser Glu Ala Ser Thr Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Tyr Gly Thr Glu Phe Thr Leu Asn Ile Asn Gly Leu Gln Pro 
    50                  55                  60                  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asp Tyr Tyr Ser Tyr Ser Arg 
65                  70                  75                  80  


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
                85                  90                  95      


Pro Ser Val Phe Pro Leu Ala 
            100             


<210>  5
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  5
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgcgg cctacggtgg ggcgttcggt aattactact ggagctgggt ccgccagtcc      120

ccagagaagg gacttgaatg gattggggaa ataagtcata gtggaagtac caactacaac      180

ccgtctctca agagtcgagt caccatgtcc gtcgacacgt ctaagacccg gttctccctg      240

aggttgagct ctgtcaacgc cgcggacacg gctatatatt actgtgcgag aggtcccttt      300

cgcccaaaat ttgttttgta tccaggtgcc tactggtact tcaatctctg gggccgtggc      360

accctggtca ctgtctcctc a                                                381


<210>  6
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  6
caggtgcagc tgcagcagtg gggagcagga ctgctgaagc ctagcgagac cctgtccctg       60

acatgcgcag catacggagg agccttcggc aactactatt ggtcctgggt gcggcagtct      120

ccagagaagg gcctggagtg gatcggcgag atctcccact ctggcagcac caactataat      180

ccctccctga agtctagggt gacaatgtct gtggacacca gcaagacacg gttctccctg      240

agactgagct ccgtgaacgc cgccgatacc gccatctact attgtgccag gggccccttc      300

cgccctaagt ttgtgctgta ccccggcgcc tactggtact tcaacctgtg gggaaggggc      360

accctggtga cagtgtctag c                                                381


<210>  7
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Gly Ala Phe Gly Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Thr Arg Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Asn Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Phe Arg Pro Lys Phe Val Leu Tyr Pro Gly Ala Tyr Trp 
            100                 105                 110         


Tyr Phe Asn Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  8
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  8
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacctgcc gggccagtca gagtatcagt aataggttgg cctggtatca acagaaacct      120

gggaaagccc ctaacctcct gatctctgag gcgtctactt tagaagatgg ggtcccatca      180

aggttcagcg gcagtggata tgggacagaa ttcactctca acattaacgg cctgcagcct      240

gatgactttg caacttatta ctgccaagac tattatagtt attctaggac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  9
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  9
gacatccaga tgacccagag cccatccaca ctgtctgcca gcgtgggcga tcgggtgacc       60

atcacatgca gagcctccca gtctatcagc aacaggctgg cctggtacca gcagaagccc      120

ggcaaggccc ctaatctgct gatctctgag gccagcaccc tggaggacgg agtgccatcc      180

cgcttctccg gatctggata cggaaccgag tttacactga acatcaatgg cctgcagccc      240

gacgatttcg ccacatacta ttgtcaggat tactatagct attcccggac ctttggccag      300

ggcacaaagc tggagatcaa g                                                321


<210>  10
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Ser Glu Ala Ser Thr Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Glu Phe Thr Leu Asn Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asp Tyr Tyr Ser Tyr Ser Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  1377
<212>  DNA
<213>  Homo sapiens

<400>  11
caggtgcagc tgcagcagtg gggagcagga ctgctgaagc ctagcgagac cctgtccctg       60

acatgcgcag catacggagg agccttcggc aactactatt ggtcctgggt gcggcagtct      120

ccagagaagg gcctggagtg gatcggcgag atctcccact ctggcagcac caactataat      180

ccctccctga agtctagggt gacaatgtct gtggacacca gcaagacacg gttctccctg      240

agactgagct ccgtgaacgc cgccgatacc gccatctact attgtgccag gggccccttc      300

cgccctaagt ttgtgctgta ccccggcgcc tactggtact tcaacctgtg gggaaggggc      360

accctggtga cagtgtctag cgccagcacc aagggccctt ccgtgtttcc actggccccc      420

tcctctaaat ccacatctgg cggcaccgcc gccctgggct gtctggtgaa ggactacttc      480

ccagagcctg tgacagtgtc ctggaactct ggcgccctga catccggcgt gcacacattt      540

ccagccgtgc tgcagagctc cggcctgtac agcctgtcta gcgtggtgac agtgccctcc      600

tctagcctgg gcacacagac ctatatctgc aacgtgaatc acaagccaag caataccaag      660

gtggacaaga aggtggagcc caagtcctgt gataagacac acacctgccc cccttgtcct      720

gctcccgagc tgctgggcgg ccctagcgtg ttcctgtttc cacccaagcc taaggacacc      780

ctgatgatct cccggacacc cgaggtgacc tgcgtggtgg tggacgtgtc tcacgaggat      840

cctgaggtga agttcaactg gtatgtggat ggcgtggagg tgcacaatgc caagaccaag      900

cccagagagg agcagtacaa ctctacatat agggtggtga gcgtgctgac cgtgctgcac      960

caggactggc tgaacggcaa ggagtataag tgcaaggtgt ccaataaggc cctgcccgcc     1020

cccatcgaga agacaatcag caaggccaag ggccagcctc gggagccaca ggtgtacacc     1080

ctgcctccat ccagagacga gctgacaaag aaccaggtgt ctctgacatg tctggtgaag     1140

ggcttctatc ctagcgatat cgccgtggag tgggagtcca atggccagcc agagaacaat     1200

tacaagacca caccccctgt gctggactcc gatggctcct tctttctgta ttccaagctg     1260

accgtggata agtctcggtg gcagcagggc aacgtgttca gctgttccgt gatgcacgaa     1320

gccctgcata atcactatac tcagaaatcc ctgtccctgt cacctggaaa gtgataa        1377


<210>  12
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ala Tyr Gly Gly Ala Phe Gly Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Thr Arg Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Asn Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Phe Arg Pro Lys Phe Val Leu Tyr Pro Gly Ala Tyr Trp 
            100                 105                 110         


Tyr Phe Asn Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  13
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  13
gacatccaga tgacccagag cccatccaca ctgtctgcca gcgtgggcga tcgggtgacc       60

atcacatgca gagcctccca gtctatcagc aacaggctgg cctggtacca gcagaagccc      120

ggcaaggccc ctaatctgct gatctctgag gccagcaccc tggaggacgg agtgccatcc      180

cgcttctccg gatctggata cggaaccgag tttacactga acatcaatgg cctgcagccc      240

gacgatttcg ccacatacta ttgtcaggat tactatagct attcccggac ctttggccag      300

ggcacaaagc tggagatcaa gaggacagtg gccgccccaa gcgtgttcat ctttccccct      360

tccgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cctcgggagg ccaaggtcca gtggaaggtg gataacgccc tgcagtctgg caatagccag      480

gagtccgtga ccgagcagga ctctaaggat agcacatatt ccctgtctag caccctgaca      540

ctgagcaagg ccgattacga gaagcacaag gtgtatgcct gtgaagtcac ccatcagggg      600

ctgtcatcac ccgtcactaa gtcattcaat cgcggagaat gctgataa                   648


<210>  14
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Ser Glu Ala Ser Thr Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Glu Phe Thr Leu Asn Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asp Tyr Tyr Ser Tyr Ser Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  15

Ala Ala Tyr Gly Gly Ala Phe Gly Asn Tyr Tyr Trp Ser 
1               5                   10              


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  16

Glu Ile Ser His Ser Gly Ser Thr Asn 
1               5                   


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  17

Ala Arg Gly Pro Phe Arg Pro Lys Phe Val Leu Tyr Pro Gly Ala Tyr 
1               5                   10                  15      


Trp Tyr Phe Asn Leu 
            20      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  18

Arg Ala Ser Gln Ser Ile Ser Asn Arg Leu Ala 
1               5                   10      


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  19

Ser Glu Ala Ser Thr Leu Glu Asp 
1               5               


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial CDR

<400>  20

Gln Asp Tyr Tyr Ser Tyr Ser Arg Thr 
1               5                   


<210>  21
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Thr Lys Ala Arg Val Met Tyr Asp Phe Ala Ala Glu Pro Gly 
1               5                   10                  15      


Asn Asn Glu Leu Thr Val Asn Glu Gly Glu Ile Ile Thr Ile Thr Asn 
            20                  25                  30          


Pro Asp Val Gly Gly Gly Trp Leu Glu Gly Arg Asn Ile Lys Gly Glu 
        35                  40                  45              


Arg Gly Leu Val Pro Thr Asp Tyr Val Glu Ile Leu Pro Ser Asp Gly 
    50                  55                  60                  


Lys Asp Gln Phe Ser Cys Gly Asn Ser Val Ala Asp Gln Ala Phe Leu 
65                  70                  75                  80  


Asp Ser Leu Ser Ala Ser Thr Ala Gln Ala Ser Ser Ser Ala Ala Ser 
                85                  90                  95      


Asn Asn His Gln Val Gly Ser Gly Asn Asp Pro Trp Ser Ala Trp Ser 
            100                 105                 110         


Ala Ser Lys Ser Gly Asn Trp Glu Ser Ser Glu Gly Trp Gly Ala Gln 
        115                 120                 125             


Pro Glu Gly Ala Gly Ala Gln Arg Asn Thr Asn Thr Pro Asn Asn Trp 
    130                 135                 140                 


Asp Thr Ala Phe Gly His Pro Gln Ala Tyr Gln Gly Pro Ala Thr Gly 
145                 150                 155                 160 


Asp Asp Asp Asp Trp Asp Glu Asp Trp Asp Gly Pro Lys Ser Ser Ser 
                165                 170                 175     


Tyr Phe Lys Asp Ser Glu Ser Ala Asp Ala Gly Gly Ala Gln Arg Gly 
            180                 185                 190         


Asn Ser Arg Ala Ser Ser Ser Ser Met Lys Ile Pro Leu Asn Lys Phe 
        195                 200                 205             


Pro Gly Phe Ala Lys Pro Gly Thr Glu Gln Tyr Leu Leu Ala Lys Gln 
    210                 215                 220                 


Leu Ala Lys Pro Lys Glu Lys Ile Pro Ile Ile Val Gly Asp Tyr Gly 
225                 230                 235                 240 


Pro Met Trp Val Tyr Pro Thr Ser Thr Phe Asp Cys Val Val Ala Asp 
                245                 250                 255     


Pro Arg Lys Gly Ser Lys Met Tyr Gly Leu Lys Ser Tyr Ile Glu Tyr 
            260                 265                 270         


Gln Leu Thr Pro Thr Asn Thr Asn Arg Ser Val Asn His Arg Tyr Lys 
        275                 280                 285             


His Phe Asp Trp Leu Tyr Glu Arg Leu Leu Val Lys Phe Gly Ser Ala 
    290                 295                 300                 


Ile Pro Ile Pro Ser Leu Pro Asp Lys Gln Val Thr Gly Arg Phe Glu 
305                 310                 315                 320 


Glu Glu Phe Ile Lys Met Arg Met Glu Arg Leu Gln Ala Trp Met Thr 
                325                 330                 335     


Arg Met Cys Arg His Pro Val Ile Ser Glu Ser Glu Val Phe Gln Gln 
            340                 345                 350         


Phe Leu Asn Phe Arg Asp Glu Lys Glu Trp Lys Thr Gly Lys Arg Lys 
        355                 360                 365             


Ala Glu Arg Asp Glu Leu Ala Gly Val Met Ile Phe Ser Thr Met Glu 
    370                 375                 380                 


Pro Glu Ala Pro Asp Leu Asp Leu Val Glu Ile Glu Gln Lys Cys Glu 
385                 390                 395                 400 


Ala Val Gly Lys Phe Thr Lys Ala Met Asp Asp Gly Val Lys Glu Leu 
                405                 410                 415     


Leu Thr Val Gly Gln Glu His Trp Lys Arg Cys Thr Gly Pro Leu Pro 
            420                 425                 430         


Lys Glu Tyr Gln Lys Ile Gly Lys Ala Leu Gln Ser Leu Ala Thr Val 
        435                 440                 445             


Phe Ser Ser Ser Gly Tyr Gln Gly Glu Thr Asp Leu Asn Asp Ala Ile 
    450                 455                 460                 


Thr Glu Ala Gly Lys Thr Tyr Glu Glu Ile Ala Ser Leu Val Ala Glu 
465                 470                 475                 480 


Gln Pro Lys Lys Asp Leu His Phe Leu Met Glu Cys Asn His Glu Tyr 
                485                 490                 495     


Lys Gly Phe Leu Gly Cys Phe Pro Asp Ile Ile Gly Thr His Lys Gly 
            500                 505                 510         


Ala Ile Glu Lys Val Lys Glu Ser Asp Lys Leu Val Ala Thr Ser Lys 
        515                 520                 525             


Ile Thr Leu Gln Asp Lys Gln Asn Met Val Lys Arg Val Ser Ile Met 
    530                 535                 540                 


Ser Tyr Ala Leu Gln Ala Glu Met Asn His Phe His Ser Asn Arg Ile 
545                 550                 555                 560 


Tyr Asp Tyr Asn Ser Val Ile Arg Leu Tyr Leu Glu Gln Gln Val Gln 
                565                 570                 575     


Phe Tyr Glu Thr Ile Ala Glu Lys Leu Arg Gln Ala Leu Ser Arg Phe 
            580                 585                 590         


Pro Val Met 
        595 


<210>  22
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Arg Ala Arg Ala Leu Tyr Asp Phe Arg Ser Glu Asn Pro 
1               5                   10                  15      


Gly Glu Ile Ser Leu Arg Glu His Glu Val Leu Ser Leu Cys Ser Glu 
            20                  25                  30          


Gln Asp Ile Glu Gly Trp Leu Glu Gly Val Asn Ser Arg Gly Asp Arg 
        35                  40                  45              


Gly Leu Phe Pro Ala Ser Tyr Val Gln Val Ile Arg Ala Pro Glu Pro 
    50                  55                  60                  


Gly Pro Ala Gly Asp Gly Gly Pro Gly Ala Pro Ala Arg Tyr Ala Asn 
65                  70                  75                  80  


Val Pro Pro Gly Gly Phe Glu Pro Leu Pro Val Ala Pro Pro Ala Ser 
                85                  90                  95      


Phe Lys Pro Pro Pro Asp Ala Phe Gln Ala Leu Leu Gln Pro Gln Gln 
            100                 105                 110         


Ala Pro Pro Pro Ser Thr Phe Gln Pro Pro Gly Ala Gly Phe Pro Tyr 
        115                 120                 125             


Gly Gly Gly Ala Leu Gln Pro Ser Pro Gln Gln Leu Tyr Gly Gly Tyr 
    130                 135                 140                 


Gln Ala Ser Gln Gly Ser Asp Asp Asp Trp Asp Asp Glu Trp Asp Asp 
145                 150                 155                 160 


Ser Ser Thr Val Ala Asp Glu Pro Gly Ala Leu Gly Ser Gly Ala Tyr 
                165                 170                 175     


Pro Asp Leu Asp Gly Ser Ser Ser Ala Gly Val Gly Ala Ala Gly Arg 
            180                 185                 190         


Tyr Arg Leu Ser Thr Arg Ser Asp Leu Ser Leu Gly Ser Arg Gly Gly 
        195                 200                 205             


Ser Val Pro Pro Gln His His Pro Ser Gly Pro Lys Ser Ser Ala Thr 
    210                 215                 220                 


Val Ser Arg Asn Leu Asn Arg Phe Ser Thr Phe Val Lys Ser Gly Gly 
225                 230                 235                 240 


Glu Ala Phe Val Leu Gly Glu Ala Ser Gly Phe Val Lys Asp Gly Asp 
                245                 250                 255     


Lys Leu Cys Val Val Leu Gly Pro Tyr Gly Pro Glu Trp Gln Glu Asn 
            260                 265                 270         


Pro Tyr Pro Phe Gln Cys Thr Ile Asp Asp Pro Thr Lys Gln Thr Lys 
        275                 280                 285             


Phe Lys Gly Met Lys Ser Tyr Ile Ser Tyr Lys Leu Val Pro Thr His 
    290                 295                 300                 


Thr Gln Val Pro Val His Arg Arg Tyr Lys His Phe Asp Trp Leu Tyr 
305                 310                 315                 320 


Ala Arg Leu Ala Glu Lys Phe Pro Val Ile Ser Val Pro His Leu Pro 
                325                 330                 335     


Glu Lys Gln Ala Thr Gly Arg Phe Glu Glu Asp Phe Ile Ser Lys Arg 
            340                 345                 350         


Arg Lys Gly Leu Ile Trp Trp Met Asn His Met Ala Ser His Pro Val 
        355                 360                 365             


Leu Ala Gln Cys Asp Val Phe Gln His Phe Leu Thr Cys Pro Ser Ser 
    370                 375                 380                 


Thr Asp Glu Lys Ala Trp Lys Gln Gly Lys Arg Lys Ala Glu Lys Asp 
385                 390                 395                 400 


Glu Met Val Gly Ala Asn Phe Phe Leu Thr Leu Ser Thr Pro Pro Ala 
                405                 410                 415     


Ala Ala Leu Asp Leu Gln Glu Val Glu Ser Lys Ile Asp Gly Phe Lys 
            420                 425                 430         


Cys Phe Thr Lys Lys Met Asp Asp Ser Ala Leu Gln Leu Asn His Thr 
        435                 440                 445             


Ala Asn Glu Phe Ala Arg Lys Gln Val Thr Gly Phe Lys Lys Glu Tyr 
    450                 455                 460                 


Gln Lys Val Gly Gln Ser Phe Arg Gly Leu Ser Gln Ala Phe Glu Leu 
465                 470                 475                 480 


Asp Gln Gln Ala Phe Ser Val Gly Leu Asn Gln Ala Ile Ala Phe Thr 
                485                 490                 495     


Gly Asp Ala Tyr Asp Ala Ile Gly Glu Leu Phe Ala Glu Gln Pro Arg 
            500                 505                 510         


Gln Asp Leu Asp Pro Val Met Asp Leu Leu Ala Leu Tyr Gln Gly His 
        515                 520                 525             


Leu Ala Asn Phe Pro Asp Ile Ile His Val Gln Lys Gly Lys Ala Trp 
    530                 535                 540                 


Pro Leu Glu Gln Val Ile Trp Ser Val Leu Cys Arg Leu Lys Gly Ala 
545                 550                 555                 560 


Thr Leu Thr Ala Val Pro Leu Trp Val Ser Glu Ser Tyr Ser Thr Gly 
                565                 570                 575     


Glu Glu Ala Ser Arg Asp Val Asp Ala Trp Val Phe Ser Leu Glu Cys 
            580                 585                 590         


Lys Leu Asp Cys Ser Thr Gly Ser Phe Leu Leu Glu Tyr Leu Ala Leu 
        595                 600                 605             


Gly Asn Glu Tyr Ser Phe Ser Lys Val Gln Arg Val Pro Leu Met Thr 
    610                 615                 620                 


Val Leu Ser Phe 
625             


<210>  23
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Leu Lys Gly Arg Ala Leu Tyr Asp Phe His Ser Glu Asn Lys 
1               5                   10                  15      


Glu Glu Ile Ser Ile Gln Gln Asp Glu Asp Leu Val Ile Phe Ser Glu 
            20                  25                  30          


Thr Ser Leu Asp Gly Trp Leu Gln Gly Gln Asn Ser Arg Gly Glu Thr 
        35                  40                  45              


Gly Leu Phe Pro Ala Ser Tyr Val Glu Ile Val Arg Ser Gly Ile Ser 
    50                  55                  60                  


Thr Asn His Ala Asp Tyr Ser Ser Ser Pro Ala Gly Ser Pro Gly Ala 
65                  70                  75                  80  


Gln Val Ser Leu Tyr Asn Ser Pro Ser Val Ala Ser Pro Ala Arg Ser 
                85                  90                  95      


Gly Gly Gly Ser Gly Phe Leu Ser Asn Gln Gly Ser Phe Glu Glu Asp 
            100                 105                 110         


Asp Asp Asp Asp Trp Asp Asp Trp Asp Asp Gly Cys Thr Val Val Glu 
        115                 120                 125             


Glu Pro Arg Ala Gly Gly Leu Gly Thr Asn Gly His Pro Pro Leu Asn 
    130                 135                 140                 


Leu Ser Tyr Pro Gly Ala Tyr Pro Ser Gln His Met Ala Phe Arg Pro 
145                 150                 155                 160 


Lys Pro Pro Leu Glu Arg Gln Asp Ser Leu Ala Ser Ala Lys Arg Gly 
                165                 170                 175     


Ser Val Val Gly Arg Asn Leu Asn Arg Phe Ser Cys Phe Val Arg Ser 
            180                 185                 190         


Gly Val Glu Ala Phe Ile Leu Gly Asp Val Pro Met Met Ala Lys Ile 
        195                 200                 205             


Ala Glu Thr Tyr Ser Ile Glu Met Gly Pro Arg Gly Pro Gln Trp Lys 
    210                 215                 220                 


Ala Asn Pro His Pro Phe Ala Cys Ser Val Glu Asp Pro Thr Lys Gln 
225                 230                 235                 240 


Thr Lys Phe Lys Gly Ile Lys Ser Tyr Ile Ser Tyr Lys Leu Thr Pro 
                245                 250                 255     


Thr His Ala Ala Ser Pro Val Tyr Arg Arg Tyr Lys His Phe Asp Trp 
            260                 265                 270         


Leu Tyr Asn Arg Leu Leu His Lys Phe Thr Val Ile Ser Val Pro His 
        275                 280                 285             


Leu Pro Glu Lys Gln Ala Thr Gly Arg Phe Glu Glu Asp Phe Ile Glu 
    290                 295                 300                 


Lys Arg Lys Arg Arg Leu Ile Leu Trp Met Asp His Met Thr Ser His 
305                 310                 315                 320 


Pro Val Leu Ser Gln Tyr Glu Gly Phe Gln His Phe Leu Ser Cys Leu 
                325                 330                 335     


Asp Asp Lys Gln Trp Lys Met Gly Lys Arg Arg Ala Glu Lys Asp Glu 
            340                 345                 350         


Met Val Gly Ala Ser Phe Leu Leu Thr Phe Gln Ile Pro Thr Glu His 
        355                 360                 365             


Gln Asp Leu Gln Asp Val Glu Asp Arg Val Asp Thr Phe Lys Ala Phe 
    370                 375                 380                 


Ser Lys Lys Met Asp Asp Ser Val Leu Gln Leu Ser Thr Val Ala Ser 
385                 390                 395                 400 


Glu Leu Val Arg Lys His Val Gly Gly Phe Arg Lys Glu Phe Gln Lys 
                405                 410                 415     


Leu Gly Ser Ala Phe Gln Ala Ile Ser His Ser Phe Gln Met Asp Pro 
            420                 425                 430         


Pro Phe Cys Ser Glu Ala Leu Asn Ser Ala Ile Ser His Thr Gly Arg 
        435                 440                 445             


Thr Tyr Glu Ala Ile Gly Glu Met Phe Ala Glu Gln Pro Lys Asn Asp 
    450                 455                 460                 


Leu Phe Gln Met Leu Asp Thr Leu Ser Leu Tyr Gln Gly Leu Leu Ser 
465                 470                 475                 480 


Asn Phe Pro Asp Ile Ile His Leu Gln Lys Gly Ala Phe Ala Lys Val 
                485                 490                 495     


Lys Glu Ser Gln Arg Met Ser Asp Glu Gly Arg Met Val Gln Asp Glu 
            500                 505                 510         


Ala Asp Gly Ile Arg Arg Arg Cys Arg Val Val Gly Phe Ala Leu Gln 
        515                 520                 525             


Ala Glu Met Asn His Phe His Gln Arg Arg Glu Leu Asp Phe Lys His 
    530                 535                 540                 


Met Met Gln Asn Tyr Leu Arg Gln Gln Ile Leu Phe Tyr Gln Arg Val 
545                 550                 555                 560 


Gly Gln Gln Leu Glu Lys Thr Leu Arg Met Tyr Asp Asn Leu 
                565                 570                 


