                         SEQUENCE LISTING

<110>  Arrowhead Pharmaceuticals Inc.
 
<120>  SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF

<130>  267602-496700

<150>  63/077,141
<151>  2020-09-11

<150>  63/214,747
<151>  2021-06-24

<150>  63/230,381
<151>  2021-08-06

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06568 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  1
uguuacagca agaucaugac c                                                 21


<210>  2
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06568 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (23)..(24)
<223>  C6-SS-C6 linked nucleoside

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-deoxythymidine-3'-phosphate

<400>  2
nggucaugau cuugcuguaa cant                                              24


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06570 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  3
ucaucuucca aagagccauc g                                                 21


<210>  4
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06570 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (23)..(24)
<223>  C6-SS-C6 linked nucleoside

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-deoxythymidine-3'-phosphate

<400>  4
ncgauggcuc uuuggaagau gant                                              24


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06326 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  5
uguuacagca agaucauggc c                                                 21


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06326 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (23)..(24)
<223>  C6-SS-C6 linked nucleoside

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-deoxythymidine-3'-phosphate

<400>  6
nggccaugau cuugcuguaa cant                                              24


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06569 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end cyclopropyl phosphonate

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  7
uguuacagca agaucaugac c                                                 21


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD06569 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (23)..(24)
<223>  C6-SS-C6 linked nucleoside

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-deoxythymidine-3'-phosphate

<400>  8
nggucaugau cuugcuguaa cant                                              24


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD07724 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end cyclopropyl phosphonate

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  9
uguuacagca agaucaugac c                                                 21


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD07724 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-propargyluridine-3'-phosphate

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-deoxythymidine-3'-phosphate

<400>  10
nggucaugau cuugcuguaa canut                                             25


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD07909 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end cyclopropyl phosphonate

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  11
uguuacagca agaucaugac c                                                 21


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD07909 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-propargyluridine-3'-phosphate

<400>  12
nggucaugau cuugcuguaa canu                                              24


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD07910 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end cyclopropyl phosphonate

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  13
uguuacagca agaucaugac c                                                 21


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD07910 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(21)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-propargyladenosine-3'-phosphate

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<400>  14
nggucaugau cuugcuguaa can                                               23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD08257 Antisense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end cyclopropyl phosphonate

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (5)..(11)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (15)..(21)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl corresponding nucleoside

<400>  15
uguuacagca agaucaugac c                                                 21


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AD08257 Sense Strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5' end (NH2-C6) modification with phosphorothioate linkage

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  inverted abasic deoxyribose residue

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<220>
<221>  modified_base
<222>  (2)..(9)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (10)..(12)
<223>  2'-fluoro corresponding nucleoside

<220>
<221>  modified_base
<222>  (13)..(22)
<223>  2'-O-methyl corresponding nucleoside

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate linked nucleoside

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  inverted abasic deoxyribose residue

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  3' end LA2 modification

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a, c, g, t or u

<400>  16
nggucaugau cuugcuguaa can                                               23


