                         SEQUENCE LISTING

<110>  ARROWHEAD PHARMACEUTICALS, INC.

<120>  RNAi Agents for Inhibiting Expression of DUX4,
Compositions thereof, and Methods of Use

<130>  30679-WO

<150>  63/214,742
<151>  2021-06-24

<150>  63/077,272
<151>  2020-09-11

<160>  239

<210>  1
<211>  1574
<212>  DNA
<213>  Homo Sapiens

<220>
<223>  Homo sapiens double homeobox 4, transcript variant 2, 
gene transcript, version NM_001293798.2 

<400>  1
atggccctcc cgacaccctc ggacagcacc ctccccgcgg aagcccgggg acgaggacgg 60

cgacggagac tcgtttggac cccgagccaa agcgaggccc tgcgagcctg ctttgagcgg 120

aacccgtacc cgggcatcgc caccagagaa cggctggccc aggccatcgg cattccggag 180

cccagggtcc agatttggtt tcagaatgag aggtcacgcc agctgaggca gcaccggcgg 240

gaatctcggc cctggcccgg gagacgcggc ccgccagaag gccggcgaaa gcggaccgcc 300

gtcaccggat cccagaccgc cctgctcctc cgagcctttg agaaggatcg ctttccaggc 360

atcgccgccc gggaggagct ggccagagag acgggcctcc cggagtccag gattcagatc 420

tggtttcaga atcgaagggc caggcacccg ggacagggtg gcagggcgcc cgcgcaggca 480

ggcggcctgt gcagcgcggc ccccggcggg ggtcaccctg ctccctcgtg ggtcgccttc 540

gcccacaccg gcgcgtgggg aacggggctt cccgcacccc acgtgccctg cgcgcctggg 600

gctctcccac agggggcttt cgtgagccag gcagcgaggg ccgcccccgc gctgcagccc 660

agccaggccg cgccggcaga ggggatctcc caacctgccc cggcgcgcgg ggatttcgcc 720

tacgccgccc cggctcctcc ggacggggcg ctctcccacc ctcaggctcc tcgctggcct 780

ccgcacccgg gcaaaagccg ggaggaccgg gacccgcagc gcgacggcct gccgggcccc 840

tgcgcggtgg cacagcctgg gcccgctcaa gcggggccgc agggccaagg ggtgcttgcg 900

ccacccacgt cccaggggag tccgtggtgg ggctggggcc ggggtcccca ggtcgccggg 960

gcggcgtggg aaccccaagc cggggcagct ccacctcccc agcccgcgcc cccggacgcc 1020

tccgcctccg cgcggcaggg gcagatgcaa ggcatcccgg cgccctccca ggcgctccag 1080

gagccggcgc cctggtctgc actcccctgc ggcctgctgc tggatgagct cctggcgagc 1140

ccggagtttc tgcagcaggc gcaacctctc ctagaaacgg aggccccggg ggagctggag 1200

gcctcggaag aggccgcctc gctggaagca cccctcagcg aggaagaata ccgggctctg 1260

ctggaggagc tttaggacgc ggggtctagg cccggtgaga gactccacac cgcggagaac 1320

tgccattctt tcctgggcat cccggggatc ccagagccgg cccaggtacc agcagacctg 1380

cgcgcagtgc gcaccccggc tgacgtgcaa gggagctcgc tggcctctct gtgcccttgt 1440

tcttccgtga aattctggct gaatgtctcc ccccaccttc cgacgctgtc taggcaaacc 1500

tggattagag ttacatctcc tggatgatta gttcagagat atattaaaat gccccctccc 1560

tgtggatcct atag                                                   1574


<210>  2
<211>  1574
<212>  DNA
<213>  Homo Sapiens

<220>
<223>  Homo sapiens double homeobox 4, transcript variant 2, 
gene transcript, version NM_001293798.3 

<400>  2
atggccctcc cgacaccctc ggacagcacc ctccccgcgg aagcccgggg acgaggacgg 60

cgacggagac tcgtttggac cccgagccaa agcgaggccc tgcgagcctg ctttgagcgg 120

aacccgtacc cgggcatcgc caccagagaa cggctggccc aggccatcgg cattccggag 180

cccagggtcc agatttggtt tcagaatgag aggtcacgcc agctgaggca gcaccggcgg 240

gaatctcggc cctggcccgg gagacgcggc ccgccagaag gccggcgaaa gcggaccgcc 300

gtcaccggat cccagaccgc cctgctcctc cgagcctttg agaaggatcg ctttccaggc 360

atcgccgccc gggaggagct ggccagagag acgggcctcc cggagtccag gattcagatc 420

tggtttcaga atcgaagggc caggcacccg ggacagggtg gcagggcgcc cgcgcaggca 480

ggcggcctgt gcagcgcggc ccccggcggg ggtcaccctg ctccctcgtg ggtcgccttc 540

gcccacaccg gcgcgtgggg aacggggctt cccgcacccc acgtgccctg cgcgcctggg 600

gctctcccac agggggcttt cgtgagccag gcagcgaggg ccgcccccgc gctgcagccc 660

agccaggccg cgccggcaga ggggatctcc caacctgccc cggcgcgcgg ggatttcgcc 720

tacgccgccc cggctcctcc ggacggggcg ctctcccacc ctcaggctcc tcggtggcct 780

ccgcacccgg gcaaaagccg ggaggaccgg gacccgcagc gcgacggcct gccgggcccc 840

tgcgcggtgg cacagcctgg gcccgctcaa gcggggccgc agggccaagg ggtgcttgcg 900

ccacccacgt cccaggggag tccgtggtgg ggctggggcc ggggtcccca ggtcgccggg 960

gcggcgtggg aaccccaagc cggggcagct ccacctcccc agcccgcgcc cccggacgcc 1020

tccgcctccg cgcggcaggg gcagatgcaa ggcatcccgg cgccctccca ggcgctccag 1080

gagccggcgc cctggtctgc actcccctgc ggcctgctgc tggatgagct cctggcgagc 1140

ccggagtttc tgcagcaggc gcaacctctc ctagaaacgg aggccccggg ggagctggag 1200

gcctcggaag aggccgcctc gctggaagca cccctcagcg aggaagaata ccgggctctg 1260

ctggaggagc tttaggacgc ggggtctagg cccggtgaga gactccactc cgcggagaac 1320

tgcctttctt tcctgggcat cccggggatc ccagagccgg cccaggtacc agcagacctg 1380

cgcgcagtgc gcaccccggc tgacgtgcaa gggagctcgc tggcctctct gtgcccttgt 1440

tcttccgtga aattctggct gaatgtctcc ccccaccttc cgacgctgtc taggcaaacc 1500

tggattagag ttacatctcc tggatgatta gttcagagat atattaaaat gccccctccc 1560

tgtggatcct atag                                                   1574


<210>  3
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  3
ggauucagau cugguuuca                                              19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  4
gauucagauc ugguuucaa                                              19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  5
ccuuguucuu ccgugaaau                                              19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  6
guucuuccgu gaaauucua                                              19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  7
accuggauua gaguuacau                                              19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  8
cuggaugauu aguucagaa                                              19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  DUX4 gene transcript (mRNA) target sequence

<400>  9
augauuaguu cagagauau                                              19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  10
ugaaaccaga ucugaaucc                                              19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  11
agaaaccaga ucugaaucc                                              19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  12
ngaaaccaga ucugaaucc                                              19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  13
ngaaaccaga ucugaaucn                                              19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  14
uugaaaccag aucugaauc                                              19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  15
augaaaccag aucugaauc                                              19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  16
nugaaaccag aucugaauc                                              19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  17
nugaaaccag aucugaaun                                              19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  18
auuucacgga agaacaagg                                              19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  19
uuuucacgga agaacaagg                                              19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  20
nuuucacgga agaacaagg                                              19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  21
nuuucacgga agaacaagn                                              19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  22
uagaauuuca cggaagaac                                              19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  23
aagaauuuca cggaagaac                                              19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  24
nagaauuuca cggaagaac                                              19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  25
nagaauuuca cggaagaan                                              19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  26
auguaacucu aauccaggu                                              19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  27
uuguaacucu aauccaggu                                              19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  28
nuguaacucu aauccaggu                                              19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  29
nuguaacucu aauccaggn                                              19


<210>  30
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  30
uucugaacua aucauccag                                              19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  31
aucugaacua aucauccag                                              19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  32
nucugaacua aucauccag                                              19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  33
nucugaacua aucauccan                                              19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  34
auaucucuga acuaaucau                                              19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  35
uuaucucuga acuaaucau                                              19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  36
nuaucucuga acuaaucau                                              19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  37
nuaucucuga acuaaucan                                              19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  38
ggauucagau cugguuuca                                              19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  39
ggauucagau cugguuucu                                              19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  40
ggauucagau cugguuucn                                              19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  41
ngauucagau cugguuucn                                              19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  42
gauucagauc ugguuucaa                                              19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  43
gauucagauc ugguuucau                                              19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  44
gauucagauc ugguuucan                                              19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  45
nauucagauc ugguuucan                                              19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  46
ccuuguucuu ccgugaaau                                              19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  47
ccuuguucuu ccgugaaaa                                              19


<210>  48
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  48
ccuuguucuu ccgugaaan                                              19


<210>  49
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  49
ncuuguucuu ccgugaaan                                              19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  50
guucuuccgu gaaauucua                                              19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  51
guucuuccgu gaaauucuu                                              19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  52
guucuuccgu gaaauucun                                              19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  53
nuucuuccgu gaaauucun                                              19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  54
accuggauua gaguuacau                                              19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  55
accuggauua gaguuacaa                                              19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  56
accuggauua gaguuacan                                              19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  57
nccuggauua gaguuacan                                              19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  58
cuggaugauu aguucagaa                                              19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  59
cuggaugauu aguucagau                                              19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  60
cuggaugauu aguucagan                                              19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  61
nuggaugauu aguucagan                                              19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  62
augauuaguu cagagauau                                              19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  63
augauuaguu cagagauaa                                              19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  64
augauuaguu cagagauan                                              19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  65
nugauuaguu cagagauan                                              19


<210>  66
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  66
ugaaaccaga ucugaauccu g                                           21


<210>  67
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  67
uugaaaccag aucugaaucc u                                           21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  68
uagaauuuca cggaagaaca g                                           21


<210>  69
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  69
uucugaacua aucauccagg a                                           21


<210>  70
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  70
auuucacgga agaacaaggg c                                           21


<210>  71
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  71
auguaacucu aauccagguu u                                           21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  72
auaucucuga acuaaucauc c                                           21


<210>  73
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  73
uagaauuuca cggaagaaca g                                           21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  74
uucugaacua aucauccagg a                                           21


<210>  75
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  75
ugaaaccaga ucugaauccu g                                           21


<210>  76
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  76
uugaaaccag aucugaaucc u                                           21


<210>  77
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  77
uugaaaccag aucugaaucc c                                           21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  78
auuucacgga agaacaaggg c                                           21


<210>  79
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  79
auguaacucu aauccagguu u                                           21


<210>  80
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  80
auaucucuga acuaaucauc c                                           21


<210>  81
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  81
uagaauuuca cggaagaaca g                                           21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  82
uagaauuuca cggaagaaca g                                           21


<210>  83
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  83
uucugaacua aucauccagg a                                           21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  84
uagaauuuca cggaagaaca g                                           21


<210>  85
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  85
uagaauuuca cggaagaaca c                                           21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  86
uagaauuuca cggaagaaca c                                           21


<210>  87
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  87
uugaaaccag aucugaaucc c                                           21


<210>  88
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  88
uugaaaccag aucugaaucc c                                           21


<210>  89
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  89
uugaaaccag aucugaaucc c                                           21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  90
uugaaaccag aucugaaucc c                                           21


<210>  91
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  91
uugaaaccag aucugaaucc c                                           21


<210>  92
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  92
uucugaacua aucauccagg a                                           21


<210>  93
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  93
uagaauuuca cggaagaaca g                                           21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  94
uagaauuuca cggaagaaca c                                           21


<210>  95
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  95
uagaauuuca cggaagaaca c                                           21


<210>  96
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  96
ugaaaccaga ucugaauccu g                                           21


<210>  97
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  97
ugaaaccaga ucugaauccu g                                           21


<210>  98
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  98
ugaaaccaga ucugaauccu g                                           21


<210>  99
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  99
ugaaaccaga ucugaauccu g                                           21


<210>  100
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  100
uagaauuuca cggaagaaca g                                           21


<210>  101
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  101
uagaauuuca cggaagaaca g                                           21


<210>  102
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  102
caggauucag aucugguuuc at                                          22


<210>  103
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  103
aggauucaga ucugguuuca at                                          22


<210>  104
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  104
cuguucuucc gugaaauucu at                                          22


<210>  105
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  105
uccuggauga uuaguucaga at                                          22


<210>  106
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  106
gcccuuguuc uuccgugaaa ut                                          22


<210>  107
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  107
naaccuggau uagaguuaca ut                                          22


<210>  108
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  108
ggaugauuag uucagagaua ut                                          22


<210>  109
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  109
guguucuucc gugaaauucu at                                          22


<210>  110
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  110
guguucuucc gugaaauucu at                                          22


<210>  111
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  111
gggauucaga ucugguuuca at                                          22


<210>  112
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  112
aggauucaga ucugguuuca at                                          22


<210>  113
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  113
gggauucaga ucugguuuca at                                          22


<210>  114
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  114
gggauucaga ucugguuuca at                                          22


<210>  115
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  115
caggauucag aucugnuuuc at                                          22


<210>  116
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  116
cuguucuucc gugaaauucu at                                          22


<210>  117
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  117
caggauucag aucugguuuc a                                           21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  118
aggauucaga ucugguuuca a                                           21


<210>  119
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  119
cuguucuucc gugaaauucu a                                           21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  120
uccuggauga uuaguucaga a                                           21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  121
gcccuuguuc uuccgugaaa u                                           21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  122
naaccuggau uagaguuaca u                                           21


<210>  123
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  123
ggaugauuag uucagagaua u                                           21


<210>  124
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  124
guguucuucc gugaaauucu a                                           21


<210>  125
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  125
guguucuucc gugaaauucu a                                           21


<210>  126
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  126
gggauucaga ucugguuuca a                                           21


<210>  127
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  127
aggauucaga ucugguuuca a                                           21


<210>  128
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  128
gggauucaga ucugguuuca a                                           21


<210>  129
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  129
gggauucaga ucugguuuca a                                           21


<210>  130
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  130
caggauucag aucugnuuuc a                                           21


<210>  131
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  131
cuguucuucc gugaaauucu a                                           21


<210>  132
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  132
caggauucag aucugguuuc a                                           21


<210>  133
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  133
aggauucaga ucugguuuca a                                           21


<210>  134
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  134
cuguucuucc gugaaauucu a                                           21


<210>  135
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  135
uccuggauga uuaguucaga a                                           21


<210>  136
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  136
gcccuuguuc uuccgugaaa u                                           21


<210>  137
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  137
naaccuggau uagaguuaca u                                           21


<210>  138
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  138
ggaugauuag uucagagaua u                                           21


<210>  139
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  139
guguucuucc gugaaauucu a                                           21


<210>  140
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  140
guguucuucc gugaaauucu a                                           21


<210>  141
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  141
gggauucaga ucugguuuca a                                           21


<210>  142
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  142
aggauucaga ucugguuuca a                                           21


<210>  143
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  143
gggauucaga ucugguuuca a                                           21


<210>  144
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  144
gggauucaga ucugguuuca a                                           21


<210>  145
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  145
caggauucag aucugnuuuc a                                           21


<210>  146
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  146
cuguucuucc gugaaauucu a                                           21


<210>  147
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  147
caggauucag aucugguuuc a                                           21


<210>  148
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  148
aggauucaga ucugguuuca a                                           21


<210>  149
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  149
cuguucuucc gugaaauucu a                                           21


<210>  150
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  150
uccuggauga uuaguucaga a                                           21


<210>  151
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  151
gcccuuguuc uuccgugaaa u                                           21


<210>  152
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  152
naaccuggau uagaguuaca u                                           21


<210>  153
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  153
ggaugauuag uucagagaua u                                           21


<210>  154
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  154
guguucuucc gugaaauucu a                                           21


<210>  155
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  155
guguucuucc gugaaauucu a                                           21


<210>  156
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  156
gggauucaga ucugguuuca a                                           21


<210>  157
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  157
aggauucaga ucugguuuca a                                           21


<210>  158
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  158
gggauucaga ucugguuuca a                                           21


<210>  159
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  159
gggauucaga ucugguuuca a                                           21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  160
caggauucag aucugnuuuc a                                           21


<210>  161
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  161
cuguucuucc gugaaauucu a                                           21


<210>  162
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  162
ugaaaccaga ucugaauccu g                                           21


<210>  163
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  163
uugaaaccag aucugaaucc u                                           21


<210>  164
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  164
uagaauuuca cggaagaaca g                                           21


<210>  165
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  165
uucugaacua aucauccagg a                                           21


<210>  166
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  166
auuucacgga agaacaaggg c                                           21


<210>  167
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  167
auguaacucu aauccagguu u                                           21


<210>  168
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  168
auaucucuga acuaaucauc c                                           21


<210>  169
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  169
uugaaaccag aucugaaucc c                                           21


<210>  170
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence 

<400>  170
uagaauuuca cggaagaaca c                                           21


<210>  171
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  171
caggauucag aucugguuuc at                                          22


<210>  172
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  172
aggauucaga ucugguuuca at                                          22


<210>  173
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  173
cuguucuucc gugaaauucu at                                          22


<210>  174
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  174
uccuggauga uuaguucaga at                                          22


<210>  175
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  175
gcccuuguuc uuccgugaaa ut                                          22


<210>  176
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<220>
<221>  modified_base
<222>  1
<223>  n = 2-aminoadenine-containing nucleotide

<400>  176
naaccuggau uagaguuaca ut                                          22


<210>  177
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  177
ggaugauuag uucagagaua ut                                          22


<210>  178
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  178
guguucuucc gugaaauucu at                                          22


<210>  179
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  179
gggauucaga ucugguuuca at                                          22


<210>  180
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<220>
<221>  modified_base
<222>  16
<223>  n = hypoxanthine (inosine)

<400>  180
caggauucag aucugnuuuc at                                          22


<210>  181
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  181
caggauucag aucugguuuc a                                           21


<210>  182
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  182
aggauucaga ucugguuuca a                                           21


<210>  183
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  183
cuguucuucc gugaaauucu a                                           21


<210>  184
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  184
uccuggauga uuaguucaga a                                           21


<210>  185
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  185
gcccuuguuc uuccgugaaa u                                           21


<210>  186
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  186
aaaccuggau uagaguuaca u                                           21


<210>  187
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  187
ggaugauuag uucagagaua u                                           21


<210>  188
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  188
guguucuucc gugaaauucu a                                           21


<210>  189
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<400>  189
gggauucaga ucugguuuca a                                           21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<220>
<221>  modified_base
<222>  16
<223>  n = hypoxanthine (inosine)

<400>  190
caggauucag aucugnuuuc a                                           21

<210>  191
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  191
caggauucag aucugguuuc a                                           21


<210>  192
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  192
aggauucaga ucugguuuca a                                           21


<210>  193
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  193
cuguucuucc gugaaauucu a                                           21


<210>  194
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  194
uccuggauga uuaguucaga a                                           21


<210>  195
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  195
gcccuuguuc uuccgugaaa u                                           21


<210>  196
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  196
naaccuggau uagaguuaca u                                           21


<210>  197
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  197
ggaugauuag uucagagaua u                                           21


<210>  198
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  198
guguucuucc gugaaauucu a                                           21


<210>  199
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  199
guguucuucc gugaaauucu a                                           21


<210>  200
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  200
gggauucaga ucugguuuca a                                           21


<210>  201
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  201
aggauucaga ucugguuuca a                                           21


<210>  202
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  202
gggauucaga ucugguuuca a                                           21


<210>  203
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  203
gggauucaga ucugguuuca a                                           21


<210>  204
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  204
caggauucag aucugnuuuc a                                           21


<210>  205
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  205
cuguucuucc gugaaauucu a                                           21


<210>  206
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  206
caggauucag aucugguuuc a                                           21


<210>  207
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  207
aggauucaga ucugguuuca a                                           21


<210>  208
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  208
cuguucuucc gugaaauucu a                                           21


<210>  209
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  209
uccuggauga uuaguucaga a                                           21


<210>  210
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  210
gcccuuguuc uuccgugaaa u                                           21


<210>  211
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  211
naaccuggau uagaguuaca u                                           21


<210>  212
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  212
ggaugauuag uucagagaua u                                           21


<210>  213
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  213
guguucuucc gugaaauucu a                                           21


<210>  214
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  214
guguucuucc gugaaauucu a                                           21


<210>  215
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  215
gggauucaga ucugguuuca a                                           21


<210>  216
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  216
aggauucaga ucugguuuca a                                           21


<210>  217
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  217
gggauucaga ucugguuuca a                                           21


<210>  218
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  218
gggauucaga ucugguuuca a                                           21


<210>  219
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  219
caggauucag aucugnuuuc a                                           21


<210>  220
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  220
cuguucuucc gugaaauucu a                                           21


<210>  221
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  221
cuguucuucc gugaaauucu a                                           21


<210>  222
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  222
caggauucag aucugguuuc a                                           21


<210>  223
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  223
cuguucuucc gugaaauucu a                                           21


<210>  224
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  224
caggauucag aucugguuuc a                                           21


<210>  225
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  225
aggauucaga ucugguuuca a                                           21


<210>  226
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  226
uccuggauga uuaguucaga a                                           21


<210>  227
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  227
naaccuggau uagaguuaca u                                           21


<210>  228
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  228
guguucuucc gugaaauucu a                                           21


<210>  229
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  229
guguucuucc gugaaauucu a                                           21


<210>  230
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  230
gcccuuguuc uuccgugaaa u                                           21


<210>  231
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  231
ggaugauuag uucagagaua u                                           21


<210>  232
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  232
gggauucaga ucugguuuca a                                           21


<210>  233
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  233
gggauucaga ucugguuuca a                                           21


<210>  234
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  234
gggauucaga ucugguuuca a                                           21


<210>  235
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  235
cuguucuucc gugaaauucu a                                           21


<210>  236
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  236
caggauucag aucugguuuc a                                           21


<210>  237
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  237
caggauucag aucugguuuc a                                           21


<210>  238
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<220>
<221>  modified_base
<222>  1
<223>  n = 2-aminoadenine-containing nucleotide

<400>  238
nggauucaga ucugguuuca at                                          22


<210>  239
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence 

<220>
<221>  modified_base
<222>  1
<223>  n = 2-aminoadenine-containing nucleotide

<400>  239
nggauucaga ucugguuuca a                                           21


