                         SEQUENCE LISTING

<110>  The Rochester General Hospital
 
<120>  Haemophilus influenzae vaccine and methods of use

<130>  33253/55894/PCT

<150>  US 63/076,461
<151>  2020-09-10

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atggaggaaa agatcgcgtt cattaacgcg ggttacatct ttcaacatca cccggaccgt       60

caagcggtgg cggacaaact ggatgcggag ttcaagccgg ttgcggaaaa actggcggcg      120

agcaagaaag aggtggacga taagattgcg gcggcgcgta agaaagtgga ggcgaaggtt      180

gcggcgctgg aaaaagacgc gccgcgtctg cgtcaggcgg atatccagaa gcgtcaagag      240

gaaattaaca aactgggtgc ggcggaggac gcggaactgc aaaaactgat gcaggagcaa      300

gataagaaag ttcaggagtt ccaggcgcaa aacgaaaagc gtcaagcgga ggaacgtggc      360

aaactgctga acagcatcca gaccgcgacc aacaacctgg cgaaggcgaa aggttacacc      420

tatgttctgg acgcgaacag cgtggttttt gcggtggaag gcaaggatat caccgaggaa      480

gttctgaaga gcattccggc gagcgagaaa gtgcaagaaa agaaactcga gcaccaccac      540

caccaccact ga                                                          552


<210>  2
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Glu Glu Lys Ile Ala Phe Ile Asn Ala Gly Tyr Ile Phe Gln His 
1               5                   10                  15      


His Pro Asp Arg Gln Ala Val Ala Asp Lys Leu Asp Ala Glu Phe Lys 
            20                  25                  30          


Pro Val Ala Glu Lys Leu Ala Ala Ser Lys Lys Glu Val Asp Asp Lys 
        35                  40                  45              


Ile Ala Ala Ala Arg Lys Lys Val Glu Ala Lys Val Ala Ala Leu Glu 
    50                  55                  60                  


Lys Asp Ala Pro Arg Leu Arg Gln Ala Asp Ile Gln Lys Arg Gln Glu 
65                  70                  75                  80  


Glu Ile Asn Lys Leu Gly Ala Ala Glu Asp Ala Glu Leu Gln Lys Leu 
                85                  90                  95      


Met Gln Glu Gln Asp Lys Lys Val Gln Glu Phe Gln Ala Gln Asn Glu 
            100                 105                 110         


Lys Arg Gln Ala Glu Glu Arg Gly Lys Leu Leu Asn Ser Ile Gln Thr 
        115                 120                 125             


Ala Thr Asn Asn Leu Ala Lys Ala Lys Gly Tyr Thr Tyr Val Leu Asp 
    130                 135                 140                 


Ala Asn Ser Val Val Phe Ala Val Glu Gly Lys Asp Ile Thr Glu Glu 
145                 150                 155                 160 


Val Leu Lys Ser Ile Pro Ala Ser Glu Lys Val Gln Glu Lys Lys Lys 
                165                 170                 175     


Leu Glu His His His His His His 
            180                 


<210>  3
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atgagcagca gcaacaacga tgcggcgggt aacggtgcgg cgcagacctt tggtggctac       60

agcgtggcgg atctgcagca acgttacaac accgtttact tcggtttcga caagtacgat      120

atcaccggcg aatatgtgca aattctggac gcgcacgcgg cgtatctgaa cgcgaccccg      180

gcggcgaagg tgctggttga gggtaacacc gatgaacgtg gcaccccgga gtacaacatt      240

gcgctgggtc agcgtcgtgc ggatgcggtt aagggctatc tggcgggtaa aggcgtggat      300

gcgggcaagc tgggcaccgt tagctacggc gaggaaaaac cggcggtgct gggtcatgat      360

gaggcggcgt acagcaagaa ccgtcgtgcg gttctggcgt atctcgagca ccaccaccac      420

caccactga                                                              429


<210>  4
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly Ala Ala Gln Thr 
1               5                   10                  15      


Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg Tyr Asn Thr Val 
            20                  25                  30          


Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu Tyr Val Gln Ile 
        35                  40                  45              


Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro Ala Ala Lys Val 
    50                  55                  60                  


Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro Glu Tyr Asn Ile 
65                  70                  75                  80  


Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly Tyr Leu Ala Gly 
                85                  90                  95      


Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser Tyr Gly Glu Glu 
            100                 105                 110         


Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr Ser Lys Asn Arg 
        115                 120                 125             


Arg Ala Val Leu Ala Tyr Lys Leu Glu His His His His His His 
    130                 135                 140             


<210>  5
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
atgggtagcc accaaatgaa gagcgagggt cacgcgaaca tgcaactgca gcaacaggcg       60

gtgctgggtc tgaactggat gcaagacagc ggcgagtaca aagcgctggc gtaccaggcg      120

tataacgcgg cgaaggtggc gttcgatcac gcgaaagttg cgaagggcaa gaaaaaggcg      180

gtggttgcgg acctggatga aaccatgctg gacaacagcc cgtatgcggg ttggcaagtg      240

cagaacaaca aaccgtttga cggcaaggat tggacccgtt gggttgatgc gcgtcaaagc      300

cgtgcggtgc cgggtgcggt tgagttcaac aactacgtga acagccacaa cggcaaagtg      360

ttttatgtta ccaaccgtaa agacagcacc gaaaagagcg gcaccatcga cgatatgaag      420

cgtctgggtt tcaacggcgt tgaggaaagc gcgttttacc tgaaaaagga caaaagcgcg      480

aaggcggcgc gttttgcgga gatcgaaaaa caaggttacg agattgtgct gtatgttggc      540

gataacctgg acgatttcgg taacaccgtg tatggcaagc tgaacgcgga ccgtcgtgcg      600

tttgttgatc aaaaccaggg taaattcggc aagaccttta ttatgctgcc gcaggcgaac      660

tatggtggct gggagggtgg cctggcggaa ggttatttta aaaaggatac ccaaggccag      720

atcaaagcgc gcctggacgc ggttcaagcg tgggacggca agcatcatca ccatcatcac      780

taa                                                                    783


<210>  6
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Gly Ser His Gln Met Lys Ser Glu Gly His Ala 
            20                  25                  30          


Asn Met Gln Leu Gln Gln Gln Ala Val Leu Gly Leu Asn Trp Met Gln 
        35                  40                  45              


Asp Ser Gly Glu Tyr Lys Ala Leu Ala Tyr Gln Ala Tyr Asn Ala Ala 
    50                  55                  60                  


Lys Val Ala Phe Asp His Ala Lys Val Ala Lys Gly Lys Lys Lys Ala 
65                  70                  75                  80  


Val Val Ala Asp Leu Asp Glu Thr Met Leu Asp Asn Ser Pro Tyr Ala 
                85                  90                  95      


Gly Trp Gln Val Gln Asn Asn Lys Pro Phe Asp Gly Lys Asp Trp Thr 
            100                 105                 110         


Arg Trp Val Asp Ala Arg Gln Ser Arg Ala Val Pro Gly Ala Val Glu 
        115                 120                 125             


Phe Asn Asn Tyr Val Asn Ser His Asn Gly Lys Val Phe Tyr Val Thr 
    130                 135                 140                 


Asn Arg Lys Asp Ser Thr Glu Lys Ser Gly Thr Ile Asp Asp Met Lys 
145                 150                 155                 160 


Arg Leu Gly Phe Asn Gly Val Glu Glu Ser Ala Phe Tyr Leu Lys Lys 
                165                 170                 175     


Asp Lys Ser Ala Lys Ala Ala Arg Phe Ala Glu Ile Glu Lys Gln Gly 
            180                 185                 190         


Tyr Glu Ile Val Leu Tyr Val Gly Asp Asn Leu Asp Asp Phe Gly Asn 
        195                 200                 205             


Thr Val Tyr Gly Lys Leu Asn Ala Asp Arg Arg Ala Phe Val Asp Gln 
    210                 215                 220                 


Asn Gln Gly Lys Phe Gly Lys Thr Phe Ile Met Leu Pro Gln Ala Asn 
225                 230                 235                 240 


Tyr Gly Gly Trp Glu Gly Gly Leu Ala Glu Gly Tyr Phe Lys Lys Asp 
                245                 250                 255     


Thr Gln Gly Gln Ile Lys Ala Arg Leu Asp Ala Val Gln Ala Trp Asp 
            260                 265                 270         


Gly Lys His His His His His His 
        275                 280 


<210>  7
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgagcagcc acagcagcaa catggcgaac acccagatga agagcgataa aatcattatt       60

gcgcaccgtg gcgcgagcgg ttacctgccg gagcacaccc tggaaagcaa agcgctggcg      120

tttgcgcagc acgcggatta tctggagcaa gacctggcga tgaccaaaga cggccgtctg      180

gtggttattc acgaccactt cctggatggt ctgaccgacg tggcgaagaa atttccgcac      240

cgtcaccgta aggatggccg ttactatgtt attgacttca ccctgaaaga aatccaaagc      300

ctggaaatga ccgagaactt tgaaaccaag gatggtaaac aggcgcaagt gtacccgaac      360

cgtttcccgc tgtggaagag ccacttccgt attcacacct ttgaggacga aattgagttt      420

atccagggcc tggagaagag caccggcaag aaagttggta tttatccgga aatcaaagcg      480

ccgtggttcc accaccaaaa cggcaaggac atcgcggcgg agaccctgaa agtgctgaag      540

aaatacggtt atgataagaa aaccgacatg gtttacctgc agaccttcga ttttaacgag      600

ctgaagcgta ttaaaaccga actgctgccg cagatgggta tggacctgaa gctggtgcaa      660

ctgatcgcgt acaccgattg gaaagagacc caagaaaagg acccgaaagg ctattgggtt      720

aactacaact atgattggat gtttaagccg ggtgcgatgg cggaagtggt taaatacgcg      780

gacggtgtgg gcccgggttg gtatatgctg gttaacaaag aggagagcaa accggataac      840

attgtgtaca ccccgctggt taaggagctg gcgcagtaca acgtggaact gcacccgtat      900

accgttcgta aagacgcgct gccggagttc tttaccgatg tgaaccaaat gtatgacacc      960

ctgctgaaca aaagcggcgc gaccggtgtg ttcaccgact ttccggatac cggcgttgaa     1020

tttctgaagg gtatcaaact cgagcaccac caccaccacc actga                     1065


<210>  8
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys Ser Asp 
1               5                   10                  15      


Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro Glu His 
            20                  25                  30          


Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His Ala Asp Tyr Leu 
        35                  40                  45              


Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val Ile His 
    50                  55                  60                  


Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe Pro His 
65                  70                  75                  80  


Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr Leu Lys 
                85                  90                  95      


Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Lys Asp Gly 
            100                 105                 110         


Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu Trp Lys Ser His 
        115                 120                 125             


Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe Ile Gln Gly Leu 
    130                 135                 140                 


Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro Glu Ile Lys Ala 
145                 150                 155                 160 


Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala Ala Glu Thr Leu 
                165                 170                 175     


Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr Asp Met Val Tyr 
            180                 185                 190         


Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile Lys Thr Glu Leu 
        195                 200                 205             


Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln Leu Ile Ala Tyr 
    210                 215                 220                 


Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys Gly Tyr Trp Val 
225                 230                 235                 240 


Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala Met Ala Glu Val 
                245                 250                 255     


Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr Met Leu Val Asn 
            260                 265                 270         


Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr Pro Leu Val Lys 
        275                 280                 285             


Glu Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr Thr Val Arg Lys 
    290                 295                 300                 


Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln Met Tyr Asp Thr 
305                 310                 315                 320 


Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr Asp Phe Pro Asp 
                325                 330                 335     


Thr Gly Val Glu Phe Leu Lys Gly Ile Lys Leu Glu His His His His 
            340                 345                 350         


His His 
        


<210>  9
<211>  849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
agcagcggca agttcaaagt ggttaccacc tttaccgtga tccaggacat tgcgcaaaac       60

gttgcgggtg atgcggcgac cgtggagagc atcaccaagc cgggtgcgga aattcacgag      120

tacgaaccga ccccgaagga catcgttaaa gcgcagagcg cggatctgat tctgtggaac      180

ggtctgaacc tggagcgttg gtttgaacgt ttctttcaga acgtgaagga caaaccggcg      240

gtggttgtga ccgagggtat ccaaccgctg agcatttacg aaggcccgta taaagatgcg      300

ccgaacccgc acgcgtggat gagcccgagc aacgcgctga tctacattga gaacatcaag      360

aacgcgctgg ttaaatatga cccgcagaac gcggcggtgt acgagaagaa cgcggcggac      420

tatgcgcaga agatcaaaca actggatgaa ccgctgcgtg cgaaactggc gcagattccg      480

gaggcgcaac gttggctggt taccagcgaa ggcgcgttca gctacctggc gaaggactat      540

aacctgaaag agggttacct gtggccgatc aacgcggaac agcaaggcac cccgcagcaa      600

gttcgtaagg tgatcgatct ggttcgtaaa aacaacattc cggttgtgtt tagcgagagc      660

accattagcg cgaagccggc gcagcaagtg gcgaaggaaa gcggtgcgaa atacggtggc      720

gttctgtatg tggacagcct gagcgcgaaa aacggcccgg ttccgaccta tatcgatctg      780

ctgaacgtta ccgtgagcac cattgtgaag ggtttcggca aactcgagca ccaccaccac      840

caccactga                                                              849


<210>  10
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ser Ser Gly Lys Phe Lys Val Val Thr Thr Phe Thr Val Ile Gln Asp 
1               5                   10                  15      


Ile Ala Gln Asn Val Ala Gly Asp Ala Ala Thr Val Glu Ser Ile Thr 
            20                  25                  30          


Lys Pro Gly Ala Glu Ile His Glu Tyr Glu Pro Thr Pro Lys Asp Ile 
        35                  40                  45              


Val Lys Ala Gln Ser Ala Asp Leu Ile Leu Trp Asn Gly Leu Asn Leu 
    50                  55                  60                  


Glu Arg Trp Phe Glu Arg Phe Phe Gln Asn Val Lys Asp Lys Pro Ala 
65                  70                  75                  80  


Val Val Val Thr Glu Gly Ile Gln Pro Leu Ser Ile Tyr Glu Gly Pro 
                85                  90                  95      


Tyr Lys Asp Ala Pro Asn Pro His Ala Trp Met Ser Pro Ser Asn Ala 
            100                 105                 110         


Leu Ile Tyr Ile Glu Asn Ile Lys Asn Ala Leu Val Lys Tyr Asp Pro 
        115                 120                 125             


Gln Asn Ala Ala Val Tyr Glu Lys Asn Ala Ala Asp Tyr Ala Gln Lys 
    130                 135                 140                 


Ile Lys Gln Leu Asp Glu Pro Leu Arg Ala Lys Leu Ala Gln Ile Pro 
145                 150                 155                 160 


Glu Ala Gln Arg Trp Leu Val Thr Ser Glu Gly Ala Phe Ser Tyr Leu 
                165                 170                 175     


Ala Lys Asp Tyr Asn Leu Lys Glu Gly Tyr Leu Trp Pro Ile Asn Ala 
            180                 185                 190         


Glu Gln Gln Gly Thr Pro Gln Gln Val Arg Lys Val Ile Asp Leu Val 
        195                 200                 205             


Arg Lys Asn Asn Ile Pro Val Val Phe Ser Glu Ser Thr Ile Ser Ala 
    210                 215                 220                 


Lys Pro Ala Gln Gln Val Ala Lys Glu Ser Gly Ala Lys Tyr Gly Gly 
225                 230                 235                 240 


Val Leu Tyr Val Asp Ser Leu Ser Ala Lys Asn Gly Pro Val Pro Thr 
                245                 250                 255     


Tyr Ile Asp Leu Leu Asn Val Thr Val Ser Thr Ile Val Lys Gly Phe 
            260                 265                 270         


Gly Lys Leu Glu His His His His His His 
        275                 280         


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly 
            20  


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Ser Gly Gly Gly Gly 
1               5       


<210>  13
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
atgaagacca ccctgaaaat gaccgcgctg gcggcgctga gcgcgttcgt tctggcgggt       60

tgcagcagcg gcgaggaaaa gatcgcgttc attaacgcgg gttacatctt tcaacatcac      120

ccggaccgtc aagcggtggc ggacaaactg gatgcggagt ttaagccggt tgcggaaaaa      180

ctggcggcga gcaagaaaga ggtggacgat aagattgcgg cggcgcgtaa gaaagtggag      240

gcgaaggttg cggcgctgga aaaagacgcg ccgcgtctgc gtcaggcgga tatccagaag      300

cgtcaagagg aaattaacaa actgggtgcg gcggaggacg cggaactgca aaaactgatg      360

caggagcaag ataagaaagt gcaggagttc caggcgcaaa acgaaaagcg tcaagcggag      420

gaacgtggca aactgctgaa cagcatccag accgcgacca acaacctggc gaaggcgaaa      480

ggttacacct atgttctgga cgcgaacagc gtggtttttg cggtggaagg caaggatatc      540

accgaggaag ttctgaagag cattccggcg agcgagaaag tgcaagaaaa gaaactcgag      600

caccaccacc accaccactg a                                                621


<210>  14
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Gly Glu Glu Lys Ile Ala Phe Ile Asn 
            20                  25                  30          


Ala Gly Tyr Ile Phe Gln His His Pro Asp Arg Gln Ala Val Ala Asp 
        35                  40                  45              


Lys Leu Asp Ala Glu Phe Lys Pro Val Ala Glu Lys Leu Ala Ala Ser 
    50                  55                  60                  


Lys Lys Glu Val Asp Asp Lys Ile Ala Ala Ala Arg Lys Lys Val Glu 
65                  70                  75                  80  


Ala Lys Val Ala Ala Leu Glu Lys Asp Ala Pro Arg Leu Arg Gln Ala 
                85                  90                  95      


Asp Ile Gln Lys Arg Gln Glu Glu Ile Asn Lys Leu Gly Ala Ala Glu 
            100                 105                 110         


Asp Ala Glu Leu Gln Lys Leu Met Gln Glu Gln Asp Lys Lys Val Gln 
        115                 120                 125             


Glu Phe Gln Ala Gln Asn Glu Lys Arg Gln Ala Glu Glu Arg Gly Lys 
    130                 135                 140                 


Leu Leu Asn Ser Ile Gln Thr Ala Thr Asn Asn Leu Ala Lys Ala Lys 
145                 150                 155                 160 


Gly Tyr Thr Tyr Val Leu Asp Ala Asn Ser Val Val Phe Ala Val Glu 
                165                 170                 175     


Gly Lys Asp Ile Thr Glu Glu Val Leu Lys Ser Ile Pro Ala Ser Glu 
            180                 185                 190         


Lys Val Gln Glu Lys Lys Leu Glu His His His His His His 
        195                 200                 205     


<210>  15
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atgaagacca ccctgaaaat gaccgcgctg gcggcgctga gcgcgtttgt gctggcgggt       60

tgcagcagca gcaacaacga tgcggcgggt aacggtgcgg cgcagacctt tggtggctac      120

agcgtggcgg atctgcagca acgttacaac accgtttact tcggtttcga caagtacgat      180

atcaccggcg aatatgtgca aattctggac gcgcacgcgg cgtatctgaa cgcgaccccg      240

gcggcgaagg tgctggttga gggtaacacc gatgaacgtg gcaccccgga gtacaacatt      300

gcgctgggtc agcgtcgtgc ggatgcggtt aagggctatc tggcgggtaa aggcgtggat      360

gcgggcaagc tgggcaccgt tagctacggc gaggaaaaac cggcggtgct gggtcatgat      420

gaggcggcgt acagcaagaa ccgtcgtgcg gttctggcgt atctcgagca ccaccaccac      480

caccactga                                                              489


<210>  16
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly 
            20                  25                  30          


Ala Ala Gln Thr Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg 
        35                  40                  45              


Tyr Asn Thr Val Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu 
    50                  55                  60                  


Tyr Val Gln Ile Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro 
65                  70                  75                  80  


Ala Ala Lys Val Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro 
                85                  90                  95      


Glu Tyr Asn Ile Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly 
            100                 105                 110         


Tyr Leu Ala Gly Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser 
        115                 120                 125             


Tyr Gly Glu Glu Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr 
    130                 135                 140                 


Ser Lys Asn Arg Arg Ala Val Leu Ala Tyr Leu Glu His His His His 
145                 150                 155                 160 


His His 
        


<210>  17
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atgaagacca ccctgaaaat gaccgcgctg gcggcgctga gcgcgtttgt gctggcgggt       60

tgcagcagcc acagcagcaa catggcgaac acccagatga agagcgataa aatcattatt      120

gcgcaccgtg gcgcgagcgg ttacctgccg gagcacaccc tggaaagcaa agcgctggcg      180

tttgcgcagc acgcggatta tctggagcaa gacctggcga tgaccaaaga cggccgtctg      240

gtggttattc acgaccactt cctggatggt ctgaccgacg tggcgaagaa atttccgcac      300

cgtcaccgta aggatggccg ttactatgtt attgacttca ccctgaaaga aatccaaagc      360

ctggaaatga ccgagaactt tgaaaccaag gatggtaaac aggcgcaagt gtacccgaac      420

cgtttcccgc tgtggaagag ccacttccgt attcacacct ttgaggacga aattgagttt      480

atccagggcc tggagaagag caccggcaag aaagttggta tttatccgga aatcaaagcg      540

ccgtggttcc accaccaaaa cggcaaggac atcgcggcgg agaccctgaa agtgctgaag      600

aaatacggtt atgataagaa aaccgacatg gtttacctgc agaccttcga ttttaacgag      660

ctgaagcgta ttaaaaccga actgctgccg cagatgggta tggacctgaa gctggtgcaa      720

ctgatcgcgt acaccgattg gaaagagacc caagaaaagg acccgaaagg ctattgggtt      780

aactacaact atgattggat gtttaagccg ggtgcgatgg cggaagtggt taaatacgcg      840

gacggtgtgg gcccgggttg gtatatgctg gttaacaaag aggagagcaa accggataac      900

attgtgtaca ccccgctggt taaggagctg gcgcagtaca acgtggaact gcacccgtat      960

accgttcgta aagacgcgct gccggagttc tttaccgatg ttaaccaaat gtatgacacc     1020

ctgctgaaca aaagcggcgc gaccggtgtg ttcaccgact ttccggatac cggcgttgaa     1080

ttcctgaagg gtatcaaact cgagcaccac caccaccacc actga                     1125


<210>  18
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln 
            20                  25                  30          


Met Lys Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr 
        35                  40                  45              


Leu Pro Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His 
    50                  55                  60                  


Ala Asp Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu 
65                  70                  75                  80  


Val Val Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys 
                85                  90                  95      


Lys Phe Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp 
            100                 105                 110         


Phe Thr Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu 
        115                 120                 125             


Thr Lys Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu 
    130                 135                 140                 


Trp Lys Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe 
145                 150                 155                 160 


Ile Gln Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro 
                165                 170                 175     


Glu Ile Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala 
            180                 185                 190         


Ala Glu Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr 
        195                 200                 205             


Asp Met Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile 
    210                 215                 220                 


Lys Thr Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln 
225                 230                 235                 240 


Leu Ile Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys 
                245                 250                 255     


Gly Tyr Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala 
            260                 265                 270         


Met Ala Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr 
        275                 280                 285             


Met Leu Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr 
    290                 295                 300                 


Pro Leu Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr 
305                 310                 315                 320 


Thr Val Arg Lys Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln 
                325                 330                 335     


Met Tyr Asp Thr Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr 
            340                 345                 350         


Asp Phe Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys Leu Glu 
        355                 360                 365             


His His His His His His 
    370                 


<210>  19
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
atgaagacca ccctgaaaat gaccgcgctg gcggcgctga gcgcgttcgt tctggcgggt       60

tgcggtagcc accaaatgaa gagcgagggt cacgcgaaca tgcaactgca gcaacaggcg      120

gtgctgggtc tgaactggat gcaagacagc ggcgagtaca aagcgctggc gtaccaggcg      180

tataacgcgg cgaaggtggc gttcgatcac gcgaaagttg cgaagggcaa gaaaaaggcg      240

gtggttgcgg acctggatga aaccatgctg gacaacagcc cgtatgcggg ttggcaagtg      300

cagaacaaca aaccgtttga cggcaaggat tggacccgtt gggttgatgc gcgtcaaagc      360

cgtgcggtgc cgggtgcggt tgagttcaac aactacgtga acagccacaa cggcaaagtg      420

ttttatgtta ccaaccgtaa agacagcacc gaaaagagcg gcaccatcga cgatatgaag      480

cgtctgggtt tcaacggcgt tgaggaaagc gcgttttacc tgaaaaagga caaaagcgcg      540

aaggcggcgc gttttgcgga gatcgaaaaa caaggttacg agattgtgct gtatgttggc      600

gataacctgg acgatttcgg taacaccgtg tatggcaagc tgaacgcgga ccgtcgtgcg      660

tttgttgatc aaaaccaggg taaattcggc aagaccttta ttatgctgcc gcaggcgaac      720

tatggtggct gggagggtgg cctggcggaa ggttatttta aaaaggatac ccaaggccag      780

atcaaagcgc gcctggacgc ggttcaagcg tgggacggca agcatcatca ccatcatcac      840

taa                                                                    843


<210>  20
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Gly Ser His Gln Met Lys Ser Glu Gly His Ala 
            20                  25                  30          


Asn Met Gln Leu Gln Gln Gln Ala Val Leu Gly Leu Asn Trp Met Gln 
        35                  40                  45              


Asp Ser Gly Glu Tyr Lys Ala Leu Ala Tyr Gln Ala Tyr Asn Ala Ala 
    50                  55                  60                  


Lys Val Ala Phe Asp His Ala Lys Val Ala Lys Gly Lys Lys Lys Ala 
65                  70                  75                  80  


Val Val Ala Asp Leu Asp Glu Thr Met Leu Asp Asn Ser Pro Tyr Ala 
                85                  90                  95      


Gly Trp Gln Val Gln Asn Asn Lys Pro Phe Asp Gly Lys Asp Trp Thr 
            100                 105                 110         


Arg Trp Val Asp Ala Arg Gln Ser Arg Ala Val Pro Gly Ala Val Glu 
        115                 120                 125             


Phe Asn Asn Tyr Val Asn Ser His Asn Gly Lys Val Phe Tyr Val Thr 
    130                 135                 140                 


Asn Arg Lys Asp Ser Thr Glu Lys Ser Gly Thr Ile Asp Asp Met Lys 
145                 150                 155                 160 


Arg Leu Gly Phe Asn Gly Val Glu Glu Ser Ala Phe Tyr Leu Lys Lys 
                165                 170                 175     


Asp Lys Ser Ala Lys Ala Ala Arg Phe Ala Glu Ile Glu Lys Gln Gly 
            180                 185                 190         


Tyr Glu Ile Val Leu Tyr Val Gly Asp Asn Leu Asp Asp Phe Gly Asn 
        195                 200                 205             


Thr Val Tyr Gly Lys Leu Asn Ala Asp Arg Arg Ala Phe Val Asp Gln 
    210                 215                 220                 


Asn Gln Gly Lys Phe Gly Lys Thr Phe Ile Met Leu Pro Gln Ala Asn 
225                 230                 235                 240 


Tyr Gly Gly Trp Glu Gly Gly Leu Ala Glu Gly Tyr Phe Lys Lys Asp 
                245                 250                 255     


Thr Gln Gly Gln Ile Lys Ala Arg Leu Asp Ala Val Gln Ala Trp Asp 
            260                 265                 270         


Gly Lys His His His His His His 
        275                 280 


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gatatacata tgaagaccac cctgaaaatg                                        30


<210>  22
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ctatatctcg agtttctttt cttgcact                                          28


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
gatatacata tggaggaaaa gatcgcgttc                                        30


<210>  24
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ctatatctcg agatacgcca gaaccgca                                          28


<210>  25
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
gatatacata tgagcagcag caacaacgat g                                      31


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
ctatatctcg agtttgatac ccttcagaa                                         29


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
gatatacata tgagcagcca cagcagcaac                                        30


<210>  28
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
atgaagacca ccctgaaaat gaccgcgctg gcggcgctga gcgcgtttgt gctggcgggt       60

tgcagcagca gcaacaacga tgcggcgggt aacggtgcgg cgcagacctt tggtggctac      120

agcgtggcgg atctgcagca acgttacaac accgtttact tcggtttcga caagtacgat      180

atcaccggcg aatatgtgca aattctggac gcgcacgcgg cgtatctgaa cgcgaccccg      240

gcggcgaagg tgctggttga gggtaacacc gatgaacgtg gcaccccgga gtacaacatt      300

gcgctgggtc agcgtcgtgc ggatgcggtt aagggctatc tggcgggtaa aggcgtggat      360

gcgggcaagc tgggcaccgt tagctacggc gaggaaaaac cggcggtgct gggtcatgat      420

gaggcggcgt acagcaagaa ccgtcgtgcg gttctggcgt atggtagtgg cggcggggga      480

gaggaaaaga tcgcgttcat taacgcgggt tacatctttc aacatcaccc ggaccgtcaa      540

gcggtggcgg acaaactgga tgcggagttt aagccggttg cggaaaaact ggcggcgagc      600

aagaaagagg tggacgataa gattgcggcg gcgcgtaaga aagtggaggc gaaggttgcg      660

gcgctggaaa aagacgcgcc gcgtctgcgt caggcggata tccagaagcg tcaagaggaa      720

attaacaaac tgggtgcggc ggaggacgcg gaactgcaaa aactgatgca ggagcaagat      780

aagaaagtgc aggagttcca ggcgcaaaac gaaaagcgtc aagcggagga acgtggcaaa      840

ctgctgaaca gcatccagac cgcgaccaac aacctggcga aggcgaaagg ttacacctat      900

gttctggacg cgaacagcgt ggtttttgcg gtggaaggca aggatatcac cgaggaagtt      960

ctgaagagca ttccggcgag cgagaaagtg caagaaaaga aactcgagca ccaccaccac     1020

caccactga                                                             1029


<210>  29
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly 
            20                  25                  30          


Ala Ala Gln Thr Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg 
        35                  40                  45              


Tyr Asn Thr Val Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu 
    50                  55                  60                  


Tyr Val Gln Ile Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro 
65                  70                  75                  80  


Ala Ala Lys Val Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro 
                85                  90                  95      


Glu Tyr Asn Ile Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly 
            100                 105                 110         


Tyr Leu Ala Gly Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser 
        115                 120                 125             


Tyr Gly Glu Glu Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr 
    130                 135                 140                 


Ser Lys Asn Arg Arg Ala Val Leu Ala Tyr Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Glu Glu Lys Ile Ala Phe Ile Asn Ala Gly Tyr Ile Phe Gln His His 
                165                 170                 175     


Pro Asp Arg Gln Ala Val Ala Asp Lys Leu Asp Ala Glu Phe Lys Pro 
            180                 185                 190         


Val Ala Glu Lys Leu Ala Ala Ser Lys Lys Glu Val Asp Asp Lys Ile 
        195                 200                 205             


Ala Ala Ala Arg Lys Lys Val Glu Ala Lys Val Ala Ala Leu Glu Lys 
    210                 215                 220                 


Asp Ala Pro Arg Leu Arg Gln Ala Asp Ile Gln Lys Arg Gln Glu Glu 
225                 230                 235                 240 


Ile Asn Lys Leu Gly Ala Ala Glu Asp Ala Glu Leu Gln Lys Leu Met 
                245                 250                 255     


Gln Glu Gln Asp Lys Lys Val Gln Glu Phe Gln Ala Gln Asn Glu Lys 
            260                 265                 270         


Arg Gln Ala Glu Glu Arg Gly Lys Leu Leu Asn Ser Ile Gln Thr Ala 
        275                 280                 285             


Thr Asn Asn Leu Ala Lys Ala Lys Gly Tyr Thr Tyr Val Leu Asp Ala 
    290                 295                 300                 


Asn Ser Val Val Phe Ala Val Glu Gly Lys Asp Ile Thr Glu Glu Val 
305                 310                 315                 320 


Leu Lys Ser Ile Pro Ala Ser Glu Lys Val Gln Glu Lys Lys Leu Glu 
                325                 330                 335     


His His His His His His 
            340         


<210>  30
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
atgaagacca ccctgaaaat gaccgcgctg gcggcgctga gcgcgttcgt tctggcgggt       60

tgcagcagcg gcgaggaaaa gatcgcgttc attaacgcgg gttacatctt tcaacatcac      120

ccggaccgtc aagcggtggc ggacaaactg gatgcggagt ttaagccggt tgcggaaaaa      180

ctggcggcga gcaagaaaga ggtggacgat aagattgcgg cggcgcgtaa gaaagtggag      240

gcgaaggttg cggcgctgga aaaagacgcg ccgcgtctgc gtcaggcgga tatccagaag      300

cgtcaagagg aaattaacaa actgggtgcg gcggaggacg cggaactgca aaaactgatg      360

caggagcaag ataagaaagt gcaggagttc caggcgcaaa acgaaaagcg tcaagcggag      420

gaacgtggca aactgctgaa cagcatccag accgcgacca acaacctggc gaaggcgaaa      480

ggttacacct atgttctgga cgcgaacagc gtggtttttg cggtggaagg caaggatatc      540

accgaggaag ttctgaagag cattccggcg agcgagaaag tgcaagaaaa gaaaggtagt      600

ggcggcgggg gaagcagcag caacaacgat gcggcgggta acggtgcggc gcagaccttt      660

ggtggctaca gcgtggcgga tctgcagcaa cgttacaaca ccgtttactt cggtttcgac      720

aagtacgata tcaccggcga atatgtgcaa attctggacg cgcacgcggc gtatctgaac      780

gcgaccccgg cggcgaaggt gctggttgag ggtaacaccg atgaacgtgg caccccggag      840

tacaacattg cgctgggtca gcgtcgtgcg gatgcggtta agggctatct ggcgggtaaa      900

ggcgtggatg cgggcaagct gggcaccgtt agctacggcg aggaaaaacc ggcggtgctg      960

ggtcatgatg aggcggcgta cagcaagaac cgtcgtgcgg ttctggcgta tctcgagcac     1020

caccaccacc accactga                                                   1038


<210>  31
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Gly Glu Glu Lys Ile Ala Phe Ile Asn 
            20                  25                  30          


Ala Gly Tyr Ile Phe Gln His His Pro Asp Arg Gln Ala Val Ala Asp 
        35                  40                  45              


Lys Leu Asp Ala Glu Phe Lys Pro Val Ala Glu Lys Leu Ala Ala Ser 
    50                  55                  60                  


Lys Lys Glu Val Asp Asp Lys Ile Ala Ala Ala Arg Lys Lys Val Glu 
65                  70                  75                  80  


Ala Lys Val Ala Ala Leu Glu Lys Asp Ala Pro Arg Leu Arg Gln Ala 
                85                  90                  95      


Asp Ile Gln Lys Arg Gln Glu Glu Ile Asn Lys Leu Gly Ala Ala Glu 
            100                 105                 110         


Asp Ala Glu Leu Gln Lys Leu Met Gln Glu Gln Asp Lys Lys Val Gln 
        115                 120                 125             


Glu Phe Gln Ala Gln Asn Glu Lys Arg Gln Ala Glu Glu Arg Gly Lys 
    130                 135                 140                 


Leu Leu Asn Ser Ile Gln Thr Ala Thr Asn Asn Leu Ala Lys Ala Lys 
145                 150                 155                 160 


Gly Tyr Thr Tyr Val Leu Asp Ala Asn Ser Val Val Phe Ala Val Glu 
                165                 170                 175     


Gly Lys Asp Ile Thr Glu Glu Val Leu Lys Ser Ile Pro Ala Ser Glu 
            180                 185                 190         


Lys Val Gln Glu Lys Lys Gly Ser Gly Gly Gly Gly Ser Ser Ser Asn 
        195                 200                 205             


Asn Asp Ala Ala Gly Asn Gly Ala Ala Gln Thr Phe Gly Gly Tyr Ser 
    210                 215                 220                 


Val Ala Asp Leu Gln Gln Arg Tyr Asn Thr Val Tyr Phe Gly Phe Asp 
225                 230                 235                 240 


Lys Tyr Asp Ile Thr Gly Glu Tyr Val Gln Ile Leu Asp Ala His Ala 
                245                 250                 255     


Ala Tyr Leu Asn Ala Thr Pro Ala Ala Lys Val Leu Val Glu Gly Asn 
            260                 265                 270         


Thr Asp Glu Arg Gly Thr Pro Glu Tyr Asn Ile Ala Leu Gly Gln Arg 
        275                 280                 285             


Arg Ala Asp Ala Val Lys Gly Tyr Leu Ala Gly Lys Gly Val Asp Ala 
    290                 295                 300                 


Gly Lys Leu Gly Thr Val Ser Tyr Gly Glu Glu Lys Pro Ala Val Leu 
305                 310                 315                 320 


Gly His Asp Glu Ala Ala Tyr Ser Lys Asn Arg Arg Ala Val Leu Ala 
                325                 330                 335     


Tyr Leu Glu His His His His His His 
            340                 345 


<210>  32
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
atgagcagca gcaacaacga tgcggcgggt aacggtgcgg cgcagacctt tggtggctac       60

agcgtggcgg atctgcagca acgttacaac accgtttact tcggtttcga caagtacgat      120

atcaccggcg aatatgtgca aattctggac gcgcacgcgg cgtatctgaa cgcgaccccg      180

gcggcgaagg tgctggttga gggtaacacc gatgaacgtg gcaccccgga gtacaacatt      240

gcgctgggtc agcgtcgtgc ggatgcggtt aagggctatc tggcgggtaa aggcgtggat      300

gcgggcaagc tgggcaccgt tagctacggc gaggaaaaac cggcggtgct gggtcatgat      360

gaggcggcgt acagcaagaa ccgtcgtgcg gttctggcgt atggtagtgg cggcggggga      420

gaggaaaaga tcgcgttcat taacgcgggt tacatctttc aacatcaccc ggaccgtcaa      480

gcggtggcgg acaaactgga tgcggagttt aagccggttg cggaaaaact ggcggcgagc      540

aagaaagagg tggacgataa gattgcggcg gcgcgtaaga aagtggaggc gaaggttgcg      600

gcgctggaaa aagacgcgcc gcgtctgcgt caggcggata tccagaagcg tcaagaggaa      660

attaacaaac tgggtgcggc ggaggacgcg gaactgcaaa aactgatgca ggagcaagat      720

aagaaagtgc aggagttcca ggcgcaaaac gaaaagcgtc aagcggagga acgtggcaaa      780

ctgctgaaca gcatccagac cgcgaccaac aacctggcga aggcgaaagg ttacacctat      840

gttctggacg cgaacagcgt ggtttttgcg gtggaaggca aggatatcac cgaggaagtt      900

ctgaagagca ttccggcgag cgagaaagtg caagaaaaga aactcgagca ccaccaccac      960

caccactga                                                              969


<210>  33
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly Ala Ala Gln Thr 
1               5                   10                  15      


Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg Tyr Asn Thr Val 
            20                  25                  30          


Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu Tyr Val Gln Ile 
        35                  40                  45              


Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro Ala Ala Lys Val 
    50                  55                  60                  


Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro Glu Tyr Asn Ile 
65                  70                  75                  80  


Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly Tyr Leu Ala Gly 
                85                  90                  95      


Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser Tyr Gly Glu Glu 
            100                 105                 110         


Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr Ser Lys Asn Arg 
        115                 120                 125             


Arg Ala Val Leu Ala Tyr Gly Ser Gly Gly Gly Gly Glu Glu Lys Ile 
    130                 135                 140                 


Ala Phe Ile Asn Ala Gly Tyr Ile Phe Gln His His Pro Asp Arg Gln 
145                 150                 155                 160 


Ala Val Ala Asp Lys Leu Asp Ala Glu Phe Lys Pro Val Ala Glu Lys 
                165                 170                 175     


Leu Ala Ala Ser Lys Lys Glu Val Asp Asp Lys Ile Ala Ala Ala Arg 
            180                 185                 190         


Lys Lys Val Glu Ala Lys Val Ala Ala Leu Glu Lys Asp Ala Pro Arg 
        195                 200                 205             


Leu Arg Gln Ala Asp Ile Gln Lys Arg Gln Glu Glu Ile Asn Lys Leu 
    210                 215                 220                 


Gly Ala Ala Glu Asp Ala Glu Leu Gln Lys Leu Met Gln Glu Gln Asp 
225                 230                 235                 240 


Lys Lys Val Gln Glu Phe Gln Ala Gln Asn Glu Lys Arg Gln Ala Glu 
                245                 250                 255     


Glu Arg Gly Lys Leu Leu Asn Ser Ile Gln Thr Ala Thr Asn Asn Leu 
            260                 265                 270         


Ala Lys Ala Lys Gly Tyr Thr Tyr Val Leu Asp Ala Asn Ser Val Val 
        275                 280                 285             


Phe Ala Val Glu Gly Lys Asp Ile Thr Glu Glu Val Leu Lys Ser Ile 
    290                 295                 300                 


Pro Ala Ser Glu Lys Val Gln Glu Lys Lys Leu Glu His His His His 
305                 310                 315                 320 


His His 
        


<210>  34
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
atggaggaaa agatcgcgtt cattaacgcg ggttacatct ttcaacatca cccggaccgt       60

caagcggtgg cggacaaact ggatgcggag tttaagccgg ttgcggaaaa actggcggcg      120

agcaagaaag aggtggacga taagattgcg gcggcgcgta agaaagtgga ggcgaaggtt      180

gcggcgctgg aaaaagacgc gccgcgtctg cgtcaggcgg atatccagaa gcgtcaagag      240

gaaattaaca aactgggtgc ggcggaggac gcggaactgc aaaaactgat gcaggagcaa      300

gataagaaag tgcaggagtt ccaggcgcaa aacgaaaagc gtcaagcgga ggaacgtggc      360

aaactgctga acagcatcca gaccgcgacc aacaacctgg cgaaggcgaa aggttacacc      420

tatgttctgg acgcgaacag cgtggttttt gcggtggaag gcaaggatat caccgaggaa      480

gttctgaaga gcattccggc gagcgagaaa gtgcaagaaa agaaaggtag tggcggcggg      540

ggaagcagca gcaacaacga tgcggcgggt aacggtgcgg cgcagacctt tggtggctac      600

agcgtggcgg atctgcagca acgttacaac accgtttact tcggtttcga caagtacgat      660

atcaccggcg aatatgtgca aattctggac gcgcacgcgg cgtatctgaa cgcgaccccg      720

gcggcgaagg tgctggttga gggtaacacc gatgaacgtg gcaccccgga gtacaacatt      780

gcgctgggtc agcgtcgtgc ggatgcggtt aagggctatc tggcgggtaa aggcgtggat      840

gcgggcaagc tgggcaccgt tagctacggc gaggaaaaac cggcggtgct gggtcatgat      900

gaggcggcgt acagcaagaa ccgtcgtgcg gttctggcgt atctcgagca ccaccaccac      960

caccactga                                                              969


<210>  35
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Glu Glu Lys Ile Ala Phe Ile Asn Ala Gly Tyr Ile Phe Gln His 
1               5                   10                  15      


His Pro Asp Arg Gln Ala Val Ala Asp Lys Leu Asp Ala Glu Phe Lys 
            20                  25                  30          


Pro Val Ala Glu Lys Leu Ala Ala Ser Lys Lys Glu Val Asp Asp Lys 
        35                  40                  45              


Ile Ala Ala Ala Arg Lys Lys Val Glu Ala Lys Val Ala Ala Leu Glu 
    50                  55                  60                  


Lys Asp Ala Pro Arg Leu Arg Gln Ala Asp Ile Gln Lys Arg Gln Glu 
65                  70                  75                  80  


Glu Ile Asn Lys Leu Gly Ala Ala Glu Asp Ala Glu Leu Gln Lys Leu 
                85                  90                  95      


Met Gln Glu Gln Asp Lys Lys Val Gln Glu Phe Gln Ala Gln Asn Glu 
            100                 105                 110         


Lys Arg Gln Ala Glu Glu Arg Gly Lys Leu Leu Asn Ser Ile Gln Thr 
        115                 120                 125             


Ala Thr Asn Asn Leu Ala Lys Ala Lys Gly Tyr Thr Tyr Val Leu Asp 
    130                 135                 140                 


Ala Asn Ser Val Val Phe Ala Val Glu Gly Lys Asp Ile Thr Glu Glu 
145                 150                 155                 160 


Val Leu Lys Ser Ile Pro Ala Ser Glu Lys Val Gln Glu Lys Lys Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly 
            180                 185                 190         


Ala Ala Gln Thr Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg 
        195                 200                 205             


Tyr Asn Thr Val Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu 
    210                 215                 220                 


Tyr Val Gln Ile Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro 
225                 230                 235                 240 


Ala Ala Lys Val Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro 
                245                 250                 255     


Glu Tyr Asn Ile Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly 
            260                 265                 270         


Tyr Leu Ala Gly Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser 
        275                 280                 285             


Tyr Gly Glu Glu Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr 
    290                 295                 300                 


Ser Lys Asn Arg Arg Ala Val Leu Ala Tyr Leu Glu His His His His 
305                 310                 315                 320 


His His 
        


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Asn Lys Phe Val Lys Ser Leu Leu Val Ala Gly Ser Val Ala Ala 
1               5                   10                  15      


Leu Ala Ala Cys 
            20  


<210>  37
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Met Gln Leu Asn Lys Val Leu Lys Gly Leu Met Ile Ala Leu Pro Val 
1               5                   10                  15      


Met Ala Ile Ala Ala Cys 
            20          


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys 
            20      


<210>  39
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly 
            20                  25                  30          


Ala Ala Gln Thr Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg 
        35                  40                  45              


Tyr Asn Thr Val Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu 
    50                  55                  60                  


Tyr Val Gln Ile Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro 
65                  70                  75                  80  


Ala Ala Lys Val Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro 
                85                  90                  95      


Glu Tyr Asn Ile Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly 
            100                 105                 110         


Tyr Leu Ala Gly Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser 
        115                 120                 125             


Tyr Gly Glu Glu Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr 
    130                 135                 140                 


Ser Lys Asn Arg Arg Ala Val Leu Ala Tyr Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys Ser Asp Lys 
                165                 170                 175     


Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro Glu His Thr 
            180                 185                 190         


Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His Ala Asp Tyr Leu Glu 
        195                 200                 205             


Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val Ile His Asp 
    210                 215                 220                 


His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe Pro His Arg 
225                 230                 235                 240 


His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr Leu Lys Glu 
                245                 250                 255     


Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Lys Asp Gly Lys 
            260                 265                 270         


Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu Trp Lys Ser His Phe 
        275                 280                 285             


Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe Ile Gln Gly Leu Glu 
    290                 295                 300                 


Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro Glu Ile Lys Ala Pro 
305                 310                 315                 320 


Trp Phe His His Gln Asn Gly Lys Asp Ile Ala Ala Glu Thr Leu Lys 
                325                 330                 335     


Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr Asp Met Val Tyr Leu 
            340                 345                 350         


Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile Lys Thr Glu Leu Leu 
        355                 360                 365             


Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln Leu Ile Ala Tyr Thr 
    370                 375                 380                 


Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys Gly Tyr Trp Val Asn 
385                 390                 395                 400 


Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala Met Ala Glu Val Val 
                405                 410                 415     


Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr Met Leu Val Asn Lys 
            420                 425                 430         


Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr Pro Leu Val Lys Glu 
        435                 440                 445             


Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr Thr Val Arg Lys Asp 
    450                 455                 460                 


Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln Met Tyr Asp Thr Leu 
465                 470                 475                 480 


Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr Asp Phe Pro Asp Thr 
                485                 490                 495     


Gly Val Glu Phe Leu Lys Gly Ile Lys 
            500                 505 


<210>  40
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln 
            20                  25                  30          


Met Lys Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr 
        35                  40                  45              


Leu Pro Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His 
    50                  55                  60                  


Ala Asp Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu 
65                  70                  75                  80  


Val Val Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys 
                85                  90                  95      


Lys Phe Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp 
            100                 105                 110         


Phe Thr Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu 
        115                 120                 125             


Thr Lys Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu 
    130                 135                 140                 


Trp Lys Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe 
145                 150                 155                 160 


Ile Gln Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro 
                165                 170                 175     


Glu Ile Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala 
            180                 185                 190         


Ala Glu Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr 
        195                 200                 205             


Asp Met Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile 
    210                 215                 220                 


Lys Thr Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln 
225                 230                 235                 240 


Leu Ile Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys 
                245                 250                 255     


Gly Tyr Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala 
            260                 265                 270         


Met Ala Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr 
        275                 280                 285             


Met Leu Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr 
    290                 295                 300                 


Pro Leu Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr 
305                 310                 315                 320 


Thr Val Arg Lys Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln 
                325                 330                 335     


Met Tyr Asp Thr Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr 
            340                 345                 350         


Asp Phe Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Lys Phe Lys Val Val Thr Thr Phe Thr Val Ile Gln 
    370                 375                 380                 


Asp Ile Ala Gln Asn Val Ala Gly Asp Ala Ala Thr Val Glu Ser Ile 
385                 390                 395                 400 


Lys Pro Gly Ala Glu Ile His Glu Tyr Glu Pro Thr Pro Lys Asp Ile 
                405                 410                 415     


Val Lys Ala Gln Ser Ala Asp Leu Ile Leu Trp Asn Gly Leu Asn Leu 
            420                 425                 430         


Glu Arg Trp Phe Glu Arg Phe Phe Gln Asn Val Lys Asp Lys Pro Ala 
        435                 440                 445             


Val Val Val Thr Glu Gly Ile Gln Pro Leu Ser Ile Tyr Glu Gly Pro 
    450                 455                 460                 


Tyr Lys Asp Ala Pro Asn Pro His Ala Trp Met Ser Pro Ser Asn Ala 
465                 470                 475                 480 


Leu Ile Tyr Ile Glu Asn Ile Lys Asn Ala Leu Val Lys Tyr Asp Pro 
                485                 490                 495     


Gln Asn Ala Ala Val Tyr Glu Lys Asn Ala Ala Asp Tyr Ala Gln Lys 
            500                 505                 510         


Ile Lys Gln Leu Asp Glu Pro Leu Arg Ala Lys Leu Ala Gln Ile Pro 
        515                 520                 525             


Glu Ala Gln Arg Trp Leu Val Thr Ser Glu Gly Ala Phe Ser Tyr Leu 
    530                 535                 540                 


Ala Lys Asp Tyr Asn Leu Lys Glu Gly Tyr Leu Trp Pro Ile Asn Ala 
545                 550                 555                 560 


Glu Gln Gln Gly Thr Pro Gln Gln Val Arg Lys Val Ile Asp Leu Val 
                565                 570                 575     


Arg Lys Asn Asn Ile Pro Val Val Phe Ser Glu Ser Thr Ile Ser Ala 
            580                 585                 590         


Lys Pro Ala Gln Gln Val Ala Lys Glu Ser Gly Ala Lys Tyr Gly Gly 
        595                 600                 605             


Val Leu Tyr Val Asp Ser Leu Ser Ala Lys Asn Gly Pro Val Pro Thr 
    610                 615                 620                 


Tyr Ile Asp Leu Leu Asn Val Thr Val Ser Thr Ile Val Lys Gly Phe 
625                 630                 635                 640 


Gly Lys 
        


<210>  41
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln 
            20                  25                  30          


Met Lys Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr 
        35                  40                  45              


Leu Pro Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His 
    50                  55                  60                  


Ala Asp Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu 
65                  70                  75                  80  


Val Val Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys 
                85                  90                  95      


Lys Phe Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp 
            100                 105                 110         


Phe Thr Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu 
        115                 120                 125             


Thr Lys Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu 
    130                 135                 140                 


Trp Lys Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe 
145                 150                 155                 160 


Ile Gln Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro 
                165                 170                 175     


Glu Ile Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala 
            180                 185                 190         


Ala Glu Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr 
        195                 200                 205             


Asp Met Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile 
    210                 215                 220                 


Lys Thr Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln 
225                 230                 235                 240 


Leu Ile Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys 
                245                 250                 255     


Gly Tyr Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala 
            260                 265                 270         


Met Ala Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr 
        275                 280                 285             


Met Leu Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr 
    290                 295                 300                 


Pro Leu Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr 
305                 310                 315                 320 


Thr Val Arg Lys Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln 
                325                 330                 335     


Met Tyr Asp Thr Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr 
            340                 345                 350         


Asp Phe Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly Ala 
    370                 375                 380                 


Ala Gln Thr Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg Tyr 
385                 390                 395                 400 


Asn Thr Val Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu Tyr 
                405                 410                 415     


Val Gln Ile Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro Ala 
            420                 425                 430         


Ala Lys Val Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro Glu 
        435                 440                 445             


Tyr Asn Ile Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly Tyr 
    450                 455                 460                 


Leu Ala Gly Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser Tyr 
465                 470                 475                 480 


Gly Glu Glu Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr Ser 
                485                 490                 495     


Lys Asn Arg Arg Ala Val Leu Ala Tyr 
            500                 505 


<210>  42
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Ser Asn Asn Asp Ala Ala Gly Asn Gly 
            20                  25                  30          


Ala Ala Gln Thr Phe Gly Gly Tyr Ser Val Ala Asp Leu Gln Gln Arg 
        35                  40                  45              


Tyr Asn Thr Val Tyr Phe Gly Phe Asp Lys Tyr Asp Ile Thr Gly Glu 
    50                  55                  60                  


Tyr Val Gln Ile Leu Asp Ala His Ala Ala Tyr Leu Asn Ala Thr Pro 
65                  70                  75                  80  


Ala Ala Lys Val Leu Val Glu Gly Asn Thr Asp Glu Arg Gly Thr Pro 
                85                  90                  95      


Glu Tyr Asn Ile Ala Leu Gly Gln Arg Arg Ala Asp Ala Val Lys Gly 
            100                 105                 110         


Tyr Leu Ala Gly Lys Gly Val Asp Ala Gly Lys Leu Gly Thr Val Ser 
        115                 120                 125             


Tyr Gly Glu Glu Lys Pro Ala Val Leu Gly His Asp Glu Ala Ala Tyr 
    130                 135                 140                 


Ser Lys Asn Arg Arg Ala Val Leu Ala Tyr Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln Met Lys Ser Asp Lys 
                165                 170                 175     


Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr Leu Pro Glu His Thr 
            180                 185                 190         


Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His Ala Asp Tyr Leu Glu 
        195                 200                 205             


Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu Val Val Ile His Asp 
    210                 215                 220                 


His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys Lys Phe Pro His Arg 
225                 230                 235                 240 


His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp Phe Thr Leu Lys Glu 
                245                 250                 255     


Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu Thr Lys Asp Gly Lys 
            260                 265                 270         


Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu Trp Lys Ser His Phe 
        275                 280                 285             


Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe Ile Gln Gly Leu Glu 
    290                 295                 300                 


Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro Glu Ile Lys Ala Pro 
305                 310                 315                 320 


Trp Phe His His Gln Asn Gly Lys Asp Ile Ala Ala Glu Thr Leu Lys 
                325                 330                 335     


Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr Asp Met Val Tyr Leu 
            340                 345                 350         


Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile Lys Thr Glu Leu Leu 
        355                 360                 365             


Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln Leu Ile Ala Tyr Thr 
    370                 375                 380                 


Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys Gly Tyr Trp Val Asn 
385                 390                 395                 400 


Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala Met Ala Glu Val Val 
                405                 410                 415     


Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr Met Leu Val Asn Lys 
            420                 425                 430         


Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr Pro Leu Val Lys Glu 
        435                 440                 445             


Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr Thr Val Arg Lys Asp 
    450                 455                 460                 


Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln Met Tyr Asp Thr Leu 
465                 470                 475                 480 


Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr Asp Phe Pro Asp Thr 
                485                 490                 495     


Gly Val Glu Phe Leu Lys Gly Ile Lys 
            500                 505 


<210>  43
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Gly Glu Glu Lys Ile Ala Phe Ile Asn 
            20                  25                  30          


Ala Gly Tyr Ile Phe Gln His His Pro Asp Arg Gln Ala Val Ala Asp 
        35                  40                  45              


Lys Leu Asp Ala Glu Phe Lys Pro Val Ala Glu Lys Leu Ala Ala Ser 
    50                  55                  60                  


Lys Lys Glu Val Asp Asp Lys Ile Ala Ala Ala Arg Lys Lys Val Glu 
65                  70                  75                  80  


Ala Lys Val Ala Ala Leu Glu Lys Asp Ala Pro Arg Leu Arg Gln Ala 
                85                  90                  95      


Asp Ile Gln Lys Arg Gln Glu Glu Ile Asn Lys Leu Gly Ala Ala Glu 
            100                 105                 110         


Asp Ala Glu Leu Gln Lys Leu Met Gln Glu Gln Asp Lys Lys Val Gln 
        115                 120                 125             


Glu Phe Gln Ala Gln Asn Glu Lys Arg Gln Ala Glu Glu Arg Gly Lys 
    130                 135                 140                 


Leu Leu Asn Ser Ile Gln Thr Ala Thr Asn Asn Leu Ala Lys Ala Lys 
145                 150                 155                 160 


Gly Tyr Thr Tyr Val Leu Asp Ala Asn Ser Val Val Phe Ala Val Glu 
                165                 170                 175     


Gly Lys Asp Ile Thr Glu Glu Val Leu Lys Ser Ile Pro Ala Ser Glu 
            180                 185                 190         


Lys Val Gln Glu Lys Lys Gly Ser Gly Gly Gly Gly Ser Ser His Ser 
        195                 200                 205             


Ser Asn Met Ala Asn Thr Gln Met Lys Ser Asp Lys Ile Ile Ile Ala 
    210                 215                 220                 


His Arg Gly Ala Ser Gly Tyr Leu Pro Glu His Thr Leu Glu Ser Lys 
225                 230                 235                 240 


Ala Leu Ala Phe Ala Gln His Ala Asp Tyr Leu Glu Gln Asp Leu Ala 
                245                 250                 255     


Met Thr Lys Asp Gly Arg Leu Val Val Ile His Asp His Phe Leu Asp 
            260                 265                 270         


Gly Leu Thr Asp Val Ala Lys Lys Phe Pro His Arg His Arg Lys Asp 
        275                 280                 285             


Gly Arg Tyr Tyr Val Ile Asp Phe Thr Leu Lys Glu Ile Gln Ser Leu 
    290                 295                 300                 


Glu Met Thr Glu Asn Phe Glu Thr Lys Asp Gly Lys Gln Ala Gln Val 
305                 310                 315                 320 


Tyr Pro Asn Arg Phe Pro Leu Trp Lys Ser His Phe Arg Ile His Thr 
                325                 330                 335     


Phe Glu Asp Glu Ile Glu Phe Ile Gln Gly Leu Glu Lys Ser Thr Gly 
            340                 345                 350         


Lys Lys Val Gly Ile Tyr Pro Glu Ile Lys Ala Pro Trp Phe His His 
        355                 360                 365             


Gln Asn Gly Lys Asp Ile Ala Ala Glu Thr Leu Lys Val Leu Lys Lys 
    370                 375                 380                 


Tyr Gly Tyr Asp Lys Lys Thr Asp Met Val Tyr Leu Gln Thr Phe Asp 
385                 390                 395                 400 


Phe Asn Glu Leu Lys Arg Ile Lys Thr Glu Leu Leu Pro Gln Met Gly 
                405                 410                 415     


Met Asp Leu Lys Leu Val Gln Leu Ile Ala Tyr Thr Asp Trp Lys Glu 
            420                 425                 430         


Thr Gln Glu Lys Asp Pro Lys Gly Tyr Trp Val Asn Tyr Asn Tyr Asp 
        435                 440                 445             


Trp Met Phe Lys Pro Gly Ala Met Ala Glu Val Val Lys Tyr Ala Asp 
    450                 455                 460                 


Gly Val Gly Pro Gly Trp Tyr Met Leu Val Asn Lys Glu Glu Ser Lys 
465                 470                 475                 480 


Pro Asp Asn Ile Val Tyr Thr Pro Leu Val Lys Glu Leu Ala Gln Tyr 
                485                 490                 495     


Asn Val Glu Leu His Pro Tyr Thr Val Arg Lys Asp Ala Leu Pro Glu 
            500                 505                 510         


Phe Phe Thr Asp Val Asn Gln Met Tyr Asp Thr Leu Leu Asn Lys Ser 
        515                 520                 525             


Gly Ala Thr Gly Val Phe Thr Asp Phe Pro Asp Thr Gly Val Glu Phe 
    530                 535                 540                 


Leu Lys Gly Ile Lys 
545                 


<210>  44
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser His Ser Ser Asn Met Ala Asn Thr Gln 
            20                  25                  30          


Met Lys Ser Asp Lys Ile Ile Ile Ala His Arg Gly Ala Ser Gly Tyr 
        35                  40                  45              


Leu Pro Glu His Thr Leu Glu Ser Lys Ala Leu Ala Phe Ala Gln His 
    50                  55                  60                  


Ala Asp Tyr Leu Glu Gln Asp Leu Ala Met Thr Lys Asp Gly Arg Leu 
65                  70                  75                  80  


Val Val Ile His Asp His Phe Leu Asp Gly Leu Thr Asp Val Ala Lys 
                85                  90                  95      


Lys Phe Pro His Arg His Arg Lys Asp Gly Arg Tyr Tyr Val Ile Asp 
            100                 105                 110         


Phe Thr Leu Lys Glu Ile Gln Ser Leu Glu Met Thr Glu Asn Phe Glu 
        115                 120                 125             


Thr Lys Asp Gly Lys Gln Ala Gln Val Tyr Pro Asn Arg Phe Pro Leu 
    130                 135                 140                 


Trp Lys Ser His Phe Arg Ile His Thr Phe Glu Asp Glu Ile Glu Phe 
145                 150                 155                 160 


Ile Gln Gly Leu Glu Lys Ser Thr Gly Lys Lys Val Gly Ile Tyr Pro 
                165                 170                 175     


Glu Ile Lys Ala Pro Trp Phe His His Gln Asn Gly Lys Asp Ile Ala 
            180                 185                 190         


Ala Glu Thr Leu Lys Val Leu Lys Lys Tyr Gly Tyr Asp Lys Lys Thr 
        195                 200                 205             


Asp Met Val Tyr Leu Gln Thr Phe Asp Phe Asn Glu Leu Lys Arg Ile 
    210                 215                 220                 


Lys Thr Glu Leu Leu Pro Gln Met Gly Met Asp Leu Lys Leu Val Gln 
225                 230                 235                 240 


Leu Ile Ala Tyr Thr Asp Trp Lys Glu Thr Gln Glu Lys Asp Pro Lys 
                245                 250                 255     


Gly Tyr Trp Val Asn Tyr Asn Tyr Asp Trp Met Phe Lys Pro Gly Ala 
            260                 265                 270         


Met Ala Glu Val Val Lys Tyr Ala Asp Gly Val Gly Pro Gly Trp Tyr 
        275                 280                 285             


Met Leu Val Asn Lys Glu Glu Ser Lys Pro Asp Asn Ile Val Tyr Thr 
    290                 295                 300                 


Pro Leu Val Lys Glu Leu Ala Gln Tyr Asn Val Glu Leu His Pro Tyr 
305                 310                 315                 320 


Thr Val Arg Lys Asp Ala Leu Pro Glu Phe Phe Thr Asp Val Asn Gln 
                325                 330                 335     


Met Tyr Asp Thr Leu Leu Asn Lys Ser Gly Ala Thr Gly Val Phe Thr 
            340                 345                 350         


Asp Phe Pro Asp Thr Gly Val Glu Phe Leu Lys Gly Ile Lys Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Glu Glu Lys Ile Ala Phe Ile Asn Ala Gly Tyr Ile 
    370                 375                 380                 


Phe Gln His His Pro Asp Arg Gln Ala Val Ala Asp Lys Leu Asp Ala 
385                 390                 395                 400 


Glu Phe Lys Pro Val Ala Glu Lys Leu Ala Ala Ser Lys Lys Glu Val 
                405                 410                 415     


Asp Asp Lys Ile Ala Ala Ala Arg Lys Lys Val Glu Ala Lys Val Ala 
            420                 425                 430         


Ala Leu Glu Lys Asp Ala Pro Arg Leu Arg Gln Ala Asp Ile Gln Lys 
        435                 440                 445             


Arg Gln Glu Glu Ile Asn Lys Leu Gly Ala Ala Glu Asp Ala Glu Leu 
    450                 455                 460                 


Gln Lys Leu Met Gln Glu Gln Asp Lys Lys Val Gln Glu Phe Gln Ala 
465                 470                 475                 480 


Gln Asn Glu Lys Arg Gln Ala Glu Glu Arg Gly Lys Leu Leu Asn Ser 
                485                 490                 495     


Ile Gln Thr Ala Thr Asn Asn Leu Ala Lys Ala Lys Gly Tyr Thr Tyr 
            500                 505                 510         


Val Leu Asp Ala Asn Ser Val Val Phe Ala Val Glu Gly Lys Asp Ile 
        515                 520                 525             


Thr Glu Glu Val Leu Lys Ser Ile Pro Ala Ser Glu Lys Val Gln Glu 
    530                 535                 540                 


Lys Lys 
545     


<210>  45
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Lys Thr Thr Leu Lys Met Thr Ala Leu Ala Ala Leu Ser Ala Phe 
1               5                   10                  15      


Val Leu Ala Gly Cys Ser Ser Gly Lys Phe Lys Val Val Thr Thr Phe 
            20                  25                  30          


Thr Val Ile Gln Asp Ile Ala Gln Asn Val Ala Gly Asp Ala Ala Thr 
        35                  40                  45              


Val Glu Ser Ile Thr Lys Pro Gly Ala Glu Ile His Glu Tyr Glu Pro 
    50                  55                  60                  


Thr Pro Lys Asp Ile Val Lys Ala Gln Ser Ala Asp Leu Ile Leu Trp 
65                  70                  75                  80  


Asn Gly Leu Asn Leu Glu Arg Trp Phe Glu Arg Phe Phe Gln Asn Val 
                85                  90                  95      


Lys Asp Lys Pro Ala Val Val Val Thr Glu Gly Ile Gln Pro Leu Ser 
            100                 105                 110         


Ile Tyr Glu Gly Pro Tyr Lys Asp Ala Pro Asn Pro His Ala Trp Met 
        115                 120                 125             


Ser Pro Ser Asn Leu Ile Tyr Ile Glu Asn Ile Lys Asn Ala Leu Val 
    130                 135                 140                 


Lys Tyr Asp Pro Gln Asn Ala Ala Val Tyr Glu Lys Asn Ala Ala Asp 
145                 150                 155                 160 


Tyr Ala Gln Lys Ile Lys Gln Leu Asp Glu Pro Leu Arg Ala Lys Leu 
                165                 170                 175     


Ala Gln Ile Pro Glu Ala Gln Arg Trp Leu Val Thr Ser Glu Gly Ala 
            180                 185                 190         


Phe Ser Tyr Leu Ala Lys Asp Tyr Asn Leu Lys Glu Gly Tyr Leu Trp 
        195                 200                 205             


Pro Ile Asn Ala Glu Gln Gln Gly Thr Pro Gln Gln Val Arg Lys Val 
    210                 215                 220                 


Ile Asp Leu Val Arg Lys Asn Asn Ile Pro Val Val Phe Ser Glu Ser 
225                 230                 235                 240 


Thr Ile Ser Ala Lys Pro Ala Gln Gln Val Ala Lys Glu Ser Gly Ala 
                245                 250                 255     


Lys Tyr Gly Gly Val Leu Tyr Val Asp Ser Leu Ser Ala Lys Asn Gly 
            260                 265                 270         


Pro Val Pro Thr Tyr Ile Asp Leu Leu Asn Val Thr Val Ser Thr Ile 
        275                 280                 285             


Val Lys Gly Phe Gly Lys Gly Ser Gly Gly Gly Gly Ser Ser Ser Asn 
    290                 295                 300                 


Asn Asp Ala Ala Gly Asn Gly Ala Ala Gln Thr Phe Gly Gly Tyr Ser 
305                 310                 315                 320 


Val Ala Asp Leu Gln Gln Arg Tyr Asn Thr Val Tyr Phe Gly Phe Asp 
                325                 330                 335     


Lys Tyr Asp Ile Thr Gly Glu Tyr Val Gln Ile Leu Asp Ala His Ala 
            340                 345                 350         


Ala Tyr Leu Asn Ala Thr Pro Ala Ala Lys Val Leu Val Glu Gly Asn 
        355                 360                 365             


Thr Asp Glu Arg Gly Thr Pro Glu Tyr Asn Ile Ala Leu Gly Gln Arg 
    370                 375                 380                 


Arg Ala Asp Ala Val Lys Gly Tyr Leu Ala Gly Lys Gly Val Asp Ala 
385                 390                 395                 400 


Gly Lys Leu Gly Thr Val Ser Tyr Gly Glu Glu Lys Pro Ala Val Leu 
                405                 410                 415     


Gly His Asp Glu Ala Ala Tyr Ser Lys Asn Arg Arg Ala Val Leu Ala 
            420                 425                 430         


Tyr 
    


