                         SEQUENCE LISTING

<110>  Eutilex Co., Ltd.
 
<120>  PD-1 POLYPEPTIDE VARIANTS

<130>  538173WO

<150>  63/075,641
<151>  2020-09-08

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  1
tttttggatt ctccagaccg gccttggaac ccgcccacgt ttagccctgc tcttttggta       60

gttacagagg gggacaacgc cacattcacc tgcagcttct ctaatacgtc cgagagcttt      120

gtactgaatt ggtatagaat gagtccatct aatcagacag ataaattggc tgccttccct      180

gaagacagga gtcagccggg tcaggactgc agattccgcg ttacgcaact cccaaatggt      240

cgagactttc atatgtcagt tgttcgggcg aggagaaatg atagcggtac ttacctgtgc      300

ggcgcgatat ctctcgcacc aaaagcacag attaaagagt ctctccgggc tgaactccgc      360

gtgacagaaa ggcgagccga ggtaccaacg gcgcacccat caccgagtcc tagacctgcg      420

ggccaattcc agactttggt tgtcgga                                          447


<210>  2
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly 
145                 


<210>  3
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 polypeptide variant PD-1.m7

<400>  3
tttctggagt cacccgaccg cccttggaac gcacctacct tttccccggc cctcttgctg       60

gtcgcagaag gagataacgc cactttcaca tgcagcttta gtaacgcctc cgaatctttt      120

catgtagttt ggcacagaga aagcccctcc ggacaaaccg acaccttggc tgcgtttccc      180

gaagaccgaa gtcaaccagg gcaggactgc cggttccgcg taacacggct gccaaacggt      240

agggacttcc acatgtcagt ggttcgagca cgccggaacg acagcgggac gtatgtctgc      300

ggagtcatta gccttgcccc gaagatacag attaaagaaa gtcttggggc agaacttcga      360

gtcaccgagc gcagggccga ggtcccaacg gcacatccca gtcctagtcc acggcccgcc      420

ggtcaatttc agacccttgt agtgggc                                          447


<210>  4
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 polypeptide variant PD-1.m7

<400>  4

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Gly Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly 
145                 


<210>  5
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 polypeptide variant PD-1.m8

<400>  5
tttttggaaa gtcccgatcg gccttggaac gctcccacat ttagcccggc cctgcttttg       60

gttgctgaag gcgataacgc cacttttaca tgcagtttca gcaacgcctc tgaaagtttc      120

catgtagtgt ggcaccgcga gtctccaagt gggcaaacag atacccttgc agctttcccg      180

gaagatagga gtcagccagg gcaggatcac cggtttagag tcactcgcct ccccaatggt      240

agagattttc acatgagcgt cgttcgagct cagagaaacg atagtggcac atacgtttgt      300

ggcgtaatat ctctcgcccc gaagatccag attaaagagt cccttggcgc ggagctgaga      360

gtcaccgaga ggcgagctga ggtgcctaca gctcatccta gcccgagccc aaggccagct      420

ggacagttcc aaactttggt tgtaggc                                          447


<210>  6
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 polypeptide variant PD-1.m8

<400>  6

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Gly Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly 
145                 


<210>  7
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 polypeptide variant euPD-1

<400>  7
tttctcgaat caccggacag accctggaat gcgcccacat tctcaccagc acttttgctg       60

gtagcagagg gcgataatgc tacattcacg tgttccttca gtaatgcaag cgagtcattt      120

catgtggttt ggcatcgaga gtcacctagt gggcagactg atacacttgc cgcattcccg      180

gaagatcgct cccagccagg tcaggatcac cggttcaggg taacccgact gccgaatggg      240

cgcgatttcc atatgagcgt tgtccgggcg caacggaacg atagtggaac atacgtgtgt      300

ggcgtaatat ccctcgctcc caaaatacaa ataaaggagt ctctgagagc agagctgaga      360

gtgacagaac gacgggcgga agttcccacg gctcatccgt caccaagtcc gcgccccgca      420

ggccaatttc aaacgctcgt cgtaggc                                          447


<210>  8
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 polypeptide variant euPD-1

<400>  8

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly 
145                 


<210>  9
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc (207-230 IMGT allele IGHG1*03, 231- 457 IMGT allele IGHG2*01)

<400>  9
agcaacacta aagtcgacaa gcgagtagaa ccgaaatcat gcgacaaaac acatacgtgc       60

cctccctgcc cagcaccacc tgtcgcgggc ccctctgttt tcctgtttcc acccaagcca      120

aaggacacat tgatgatttc ccggactcct gaagtcacct gcgtggtagt agatgtatca      180

catgaagatc cagaagtcca gttcaactgg tatgtggacg gagtagaggt acataatgcc      240

aagaccaaac cacgggaaga gcagttcaac agtactttcc gggtagttag cgttttgact      300

gtcgtacacc aagactggct taatggaaaa gaatacaagt gtaaggtaag caacaagggc      360

ctgccggctc cgatagagaa aaccattagc aagacaaagg gccaaccacg cgaaccccag      420

gtatataccc tcccaccgtc ccgcgaggag atgactaaga atcaagtttc tctcacgtgc      480

ttggtaaagg gcttctatcc gagcgatata gccgtggagt gggagtctaa tggtcagccc      540

gaaaacaatt acaaaactac gcctcctatg ctggacagtg atgggagctt ctttctttac      600

agtaagctta ccgtggacaa gtctcggtgg caacaaggaa atgtttttag ttgttctgta      660

atgcatgaag cacttcataa ccattacacc cagaaaagtc tgagcttgtc cccgggaaaa      720


<210>  10
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc (207-230 IMGT allele IGHG1*03, 231- 457 IMGT allele IGHG2*01)

<400>  10

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
            20                  25                  30          


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        35                  40                  45              


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    50                  55                  60                  


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
65                  70                  75                  80  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
                85                  90                  95      


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            100                 105                 110         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
        115                 120                 125             


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
145                 150                 155                 160 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                165                 170                 175     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    210                 215                 220                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 240 


<210>  11
<211>  288
<212>  PRT
<213>  Homo Sapience

<400>  11

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  12
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  euPD-1 x 94kvt HLC 218

<400>  12

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                165                 170                 175     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            180                 185                 190         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        195                 200                 205             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    210                 215                 220                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
225                 230                 235                 240 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                325                 330                 335     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
385                 390                 395                 400 


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
                405                 410                 415     


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr Trp Met His 
            420                 425                 430         


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile 
        435                 440                 445             


Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe Lys Ser Arg 
    450                 455                 460                 


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu 
465                 470                 475                 480 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 
                485                 490                 495     


Phe Lys Thr Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            500                 505                 510         


Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
        515                 520                 525             


Glu Gly Ser Thr Lys Gly Asp Ile Val Met Thr Gln Ser Pro Ala Phe 
    530                 535                 540                 


Leu Ser Val Thr Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
545                 550                 555                 560 


Gln Thr Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Pro Asp Gln 
                565                 570                 575     


Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile 
            580                 585                 590         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        595                 600                 605             


Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asp 
    610                 615                 620                 


Gly His Ser Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
625                 630                 635                 640 


Lys 
    


<210>  13
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  euPD-1.2 x 94kvt HLC 218

<400>  13

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro 
                165                 170                 175     


Thr Phe Ser Pro Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr 
            180                 185                 190         


Phe Thr Cys Ser Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp 
        195                 200                 205             


His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro 
    210                 215                 220                 


Glu Asp Arg Ser Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg 
225                 230                 235                 240 


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg 
                245                 250                 255     


Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys 
            260                 265                 270         


Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        275                 280                 285             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    290                 295                 300                 


Gly Gln Phe Gln Thr Leu Val Val Gly Ala Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                325                 330                 335     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            340                 345                 350         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        355                 360                 365             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    370                 375                 380                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
385                 390                 395                 400 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                405                 410                 415     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
            420                 425                 430         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        435                 440                 445             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
465                 470                 475                 480 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                485                 490                 495     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            500                 505                 510         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        515                 520                 525             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    530                 535                 540                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
                565                 570                 575     


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser 
            580                 585                 590         


Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        595                 600                 605             


Ile Gly Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys 
    610                 615                 620                 


Phe Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala 
625                 630                 635                 640 


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                645                 650                 655     


Cys Ala Arg Ser Phe Lys Thr Ala Arg Ala Phe Ala Tyr Trp Gly Gln 
            660                 665                 670         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys 
        675                 680                 685             


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Met Thr Gln 
    690                 695                 700                 


Ser Pro Ala Phe Leu Ser Val Thr Pro Gly Glu Lys Val Thr Ile Thr 
705                 710                 715                 720 


Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln 
                725                 730                 735     


Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser 
            740                 745                 750         


Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        755                 760                 765             


Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
    770                 775                 780                 


Tyr Cys Gln Asp Gly His Ser Trp Pro Pro Thr Phe Gly Gln Gly Thr 
785                 790                 795                 800 


Lys Leu Glu Ile Lys 
                805 


<210>  14
<211>  641
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  euPD-1 x 94kvt LHC 218

<400>  14

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                165                 170                 175     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            180                 185                 190         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        195                 200                 205             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    210                 215                 220                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
225                 230                 235                 240 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                245                 250                 255     


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
            260                 265                 270         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        275                 280                 285             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    290                 295                 300                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
305                 310                 315                 320 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                325                 330                 335     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            340                 345                 350         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        355                 360                 365             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    370                 375                 380                 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
385                 390                 395                 400 


Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly Glu Lys Val 
                405                 410                 415     


Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr Leu His Trp 
            420                 425                 430         


Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile Lys Tyr Ala 
        435                 440                 445             


Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    450                 455                 460                 


Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala Glu Asp Ala 
465                 470                 475                 480 


Ala Thr Tyr Tyr Cys Gln Asp Gly His Ser Trp Pro Pro Thr Phe Gly 
                485                 490                 495     


Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys 
            500                 505                 510         


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln 
        515                 520                 525             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Leu Ser Cys 
    530                 535                 540                 


Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg 
545                 550                 555                 560 


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Gly 
                565                 570                 575     


Asn Gly His Thr Asn Tyr Asn Glu Lys Phe Lys Ser Arg Val Thr Met 
            580                 585                 590         


Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
        595                 600                 605             


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Phe Lys Thr 
    610                 615                 620                 


Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser 
    


<210>  15
<211>  805
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  euPD-1.2 x 94kvt LHC 218

<400>  15

Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val Val Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Phe Leu Glu Ser Pro Asp Arg Pro Trp Asn Ala Pro 
                165                 170                 175     


Thr Phe Ser Pro Ala Leu Leu Leu Val Ala Glu Gly Asp Asn Ala Thr 
            180                 185                 190         


Phe Thr Cys Ser Phe Ser Asn Ala Ser Glu Ser Phe His Val Val Trp 
        195                 200                 205             


His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro 
    210                 215                 220                 


Glu Asp Arg Ser Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Arg 
225                 230                 235                 240 


Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg 
                245                 250                 255     


Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys 
            260                 265                 270         


Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        275                 280                 285             


Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala 
    290                 295                 300                 


Gly Gln Phe Gln Thr Leu Val Val Gly Ala Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                325                 330                 335     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            340                 345                 350         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        355                 360                 365             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    370                 375                 380                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
385                 390                 395                 400 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                405                 410                 415     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
            420                 425                 430         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        435                 440                 445             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
465                 470                 475                 480 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                485                 490                 495     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            500                 505                 510         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        515                 520                 525             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    530                 535                 540                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Asp Ile Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro 
                565                 570                 575     


Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp 
            580                 585                 590         


Tyr Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu 
        595                 600                 605             


Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 
    610                 615                 620                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu 
625                 630                 635                 640 


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asp Gly His Ser Trp Pro 
                645                 650                 655     


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser 
            660                 665                 670         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val 
        675                 680                 685             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    690                 695                 700                 


Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr Trp Met 
705                 710                 715                 720 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu 
                725                 730                 735     


Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe Lys Ser 
            740                 745                 750         


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
        755                 760                 765             


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    770                 775                 780                 


Ser Phe Lys Thr Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
785                 790                 795                 800 


Val Thr Val Ser Ser 
                805 


<210>  16
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  94kvt VH

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Lys Thr Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  94kvt VL

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asp Gly His Ser Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)2

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  218

<400>  21

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  22
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  94kvt HLC 218

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Lys Thr Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Ala Phe Leu Ser Val Thr Pro Gly Glu Lys Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Thr Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Asp Gln Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile 
            180                 185                 190         


Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Asp Gly His Ser Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  23
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  94kvt LHC 218

<400>  23

Asp Ile Val Met Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asp Gly His Ser Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr Trp Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile 
                165                 170                 175     


Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe Lys Ser Arg 
            180                 185                 190         


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu 
        195                 200                 205             


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Phe Lys Thr Ala Arg Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


