               SEQUENCE LISTING

<110> Ludwig-Maximilians-Universität München

<120> Engineered AAV vectors

<130> 116847P1272PC

<150> EP20195554.9
<151> 2020-09-10

<160> 74

<170> BiSSAP 1.3.6

<210> 1
<211> 736
<212> PRT
<213> Adeno-associated virus - 1


<220> 
<223> AAV1 Cap Sequence (AAD27757)

<400> 1
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         
Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     
Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 
Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     
Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         
Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 
Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     



<210> 2
<211> 735
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> AAV2 Cap (P03135.2)

<400> 2
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 
His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     
Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             
Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 
Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 
Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 

<210> 3
<211> 736
<212> PRT
<213> Adeno-associated virus - 3


<220> 
<223> AAV3B Cap Sequence

<400> 3
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 
Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         
Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             
Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 
Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 
Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     
Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         
Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             
Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 
Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 
Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     
Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         
Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 
Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     
Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 
Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     



<210> 4
<211> 734
<212> PRT
<213> Adeno-associated virus - 4


<220> 
<223> AAV4 Cap Sequence

<400> 4
Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      
Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          
Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              
Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  
Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  
Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      
Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         
Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             
Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 
Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 
Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     
Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         
Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             
Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 
Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 
Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     
Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         
Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             
Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 
Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 
Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     
Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         
Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             
Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 
Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 
Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     
Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         
Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             
Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 
Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 
Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     
Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         
Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             
Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 
Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 
Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     
Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         
Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             
Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 
Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 
Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     
Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         
Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             
Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 
Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 
Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 

<210> 5
<211> 724
<212> PRT
<213> Adeno-associated virus - 5


<220> 
<223> AAV5 Cap Sequence

<400> 5
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      
Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          
Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  
Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             
Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 
Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 
Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     
Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         
Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             
Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 
Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 
Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     
Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         
Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             
Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 
Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 
Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     
Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         
Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             
Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 
Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 
Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     
Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         
Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             
Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 
Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 
Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     
Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         
Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             
Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 
Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 
Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     
Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         
Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             
Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 
Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 
Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     
Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         
Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             
Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 
Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 
Thr Arg Pro Leu 
                

<210> 6
<211> 736
<212> PRT
<213> Adeno-associated virus - 6


<220> 
<223> AAV6 Cap Sequence

<400> 6
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 
Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         
Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             
Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 
Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     
Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         
Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     



<210> 7
<211> 737
<212> PRT
<213> Adeno-associated virus - 7


<220> 
<223> AAV7 Cap Sequence

<400> 7
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         
Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 
Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     
Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         
Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 
Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 
Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     
Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         
Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 
Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     
Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             
Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 
Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 
Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         
Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             
His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 
Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 
Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     
Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         
Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             
Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 
His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 
Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     
Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         
Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             
Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 
Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 
Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     
Leu 
    

<210> 8
<211> 738
<212> PRT
<213> Adeno-associated virus - 8


<220> 
<223> AAV8 Cap Sequence

<400> 8
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         
Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             
Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 
Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         
Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 
Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     
Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         
Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     
Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 
Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     
Asn Leu 
        

<210> 9
<211> 736
<212> PRT
<213> Adeno-associated virus - 9


<220> 
<223> AAV9 Cap Sequence (Q6JC40)

<400> 9
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     



<210> 10
<211> 738
<212> PRT
<213> Adeno-associated virus - 10


<220> 
<223> AAV10 Cap Sequence

<400> 10
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 
Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     
Thr Gly Glu Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         
Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             
Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 
Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         
Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 
Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     
Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Ala Asn Thr Gly 
            580                 585                 590         
Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     
Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 
Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 
Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     
Asn Leu 
        

<210> 11
<211> 197
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 333 to 529 of of SARS-CoV-2 S protein (YP_009724390.1) (S1.1))

<400> 11
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            20                  25                  30          
Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              
Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  
Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  
Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      
Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        115                 120                 125             
Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 
Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 
Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     
Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            180                 185                 190         
Cys Gly Pro Lys Lys 
        195         

<210> 12
<211> 254
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> aa 330 to 583 of SARS-CoV-2 S protein (YP_009724390.1)

<400> 12
Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
1               5                   10                  15      
Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
            20                  25                  30          
Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
        35                  40                  45              
Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
    50                  55                  60                  
Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
65                  70                  75                  80  
Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
                85                  90                  95      
Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
            100                 105                 110         
Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
        115                 120                 125             
Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
    130                 135                 140                 
Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
145                 150                 155                 160 
Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
                165                 170                 175     
Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
            180                 185                 190         
Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
        195                 200                 205             
Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
    210                 215                 220                 
Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
225                 230                 235                 240 
Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                245                 250                 

<210> 13
<211> 938
<212> PRT
<213> Artificial Sequence


<220> 
<223> HtW2_S1.1 Cap Protein Sequence

<400> 13
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Ala Ala Ala Thr Asn 
            580                 585                 590         
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
        595                 600                 605             
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
    610                 615                 620                 
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
625                 630                 635                 640 
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
                645                 650                 655     
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
            660                 665                 670         
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
        675                 680                 685             
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
    690                 695                 700                 
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
705                 710                 715                 720 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
                725                 730                 735     
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
            740                 745                 750         
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
        755                 760                 765             
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
    770                 775                 780                 
Pro Lys Lys Gly Ala Ala Arg Gln Ala Ala Thr Ala Asp Val Asn Thr 
785                 790                 795                 800 
Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu 
                805                 810                 815     
Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His 
            820                 825                 830         
Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln 
        835                 840                 845             
Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe 
    850                 855                 860                 
Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln 
865                 870                 875                 880 
Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg 
                885                 890                 895     
Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn 
            900                 905                 910         
Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro 
        915                 920                 925             
Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
    930                 935             

<210> 14
<211> 937
<212> PRT
<213> Artificial Sequence


<220> 
<223> HtW9_S1.1 Cap Protein Sequence

<400> 14
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Ala Ala Thr 
            580                 585                 590         
Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
        595                 600                 605             
Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
    610                 615                 620                 
Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
625                 630                 635                 640 
Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
                645                 650                 655     
Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
            660                 665                 670         
Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
        675                 680                 685             
Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
    690                 695                 700                 
Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
705                 710                 715                 720 
Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
                725                 730                 735     
Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
            740                 745                 750         
Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
        755                 760                 765             
Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
    770                 775                 780                 
Gly Pro Lys Lys Ala Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln 
785                 790                 795                 800 
Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln 
                805                 810                 815     
Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
            820                 825                 830         
Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile 
        835                 840                 845             
Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn 
    850                 855                 860                 
Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
865                 870                 875                 880 
Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
                885                 890                 895     
Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val 
            900                 905                 910         
Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile 
        915                 920                 925             
Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
    930                 935         

<210> 15
<211> 1273
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> Full length SARS-CoV-2 S protein (YP_009724390.1)

<400> 15
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005            
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                1015                1020                
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                1030                1035                1040
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                1050                1055    
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                1065                1070        
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                1080                1085            
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                1095                1100                
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                1110                1115                1120
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                1130                1135    
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                1145                1150        
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                1160                1165            
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                1175                1180                
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                1190                1195                1200
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                1210                1215    
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                1225                1230        
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                1240                1245            
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                1255                1260                
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                1270            

<210> 16
<211> 11
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> AAV2 marked 450-460

<400> 16
Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu 
1               5                   10      

<210> 17
<211> 8
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> AAV2 marked 585-592

<400> 17
Arg Gly Asn Arg Gln Ala Ala Thr 
1               5               

<210> 18
<211> 11
<212> PRT
<213> Adeno-associated virus - 9


<220> 
<223> AAV9 marked 450-460

<400> 18
Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr 
1               5                   10      

<210> 19
<211> 8
<212> PRT
<213> Adeno-associated virus - 9


<220> 
<223> AAV9 marked 585-592

<400> 19
Gln Ser Ala Gln Ala Gln Ala Gln 
1               5               

<210> 20
<211> 11
<212> PRT
<213> Adeno-associated virus - 1


<220> 
<223> AAV1 marked 450-460

<400> 20
Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp 
1               5                   10      

<210> 21
<211> 8
<212> PRT
<213> Adeno-associated virus - 1


<220> 
<223> AAV1 marked 585-592

<400> 21
Gln Ser Ser Ser Thr Asp Pro Ala 
1               5               

<210> 22
<211> 11
<212> PRT
<213> Adeno-associated virus - 8


<220> 
<223> AAV8 marked 450-460

<400> 22
Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr 
1               5                   10      

<210> 23
<211> 8
<212> PRT
<213> Adeno-associated virus - 8


<220> 
<223> AAV8 marked 585-592

<400> 23
Asn Leu Gln Gln Gln Asn Thr Ala 
1               5               

<210> 24
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW2_S1.1_fw

<400> 24
ctaccaacct ccagagaggc aacgcggccg caactaatct ttgtccgttc ggtgaggttt     60


<210> 25
<211> 55
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW2_S1.1_rv

<400> 25
tgacatctgc ggtagctgct tggcgcgccg ctcccttttt gggcccacaa actgt          55


<210> 26
<211> 60
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW9_S1.1_fw

<400> 26
ccacaaacca ccagagtgcc caagcggccg caactaatct ttgtccgttc ggtgaggttt     60


<210> 27
<211> 55
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW9_S1.1_rv

<400> 27
tttgaaccca accggtctgc gcctgtgccg cctttttggg cccacaaact gtagc          55


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW9_S1.1_BB_fw

<400> 28
gcacaggcgc agaccggttg ggttcaaaac caa                                  33


<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW9_S1.1_BB_rv

<400> 29
ttgggcactc tggtggtttg tgg                                            23


<210> 30
<211> 805
<212> PRT
<213> Homo sapiens


<220> 
<223> Human ACE2 Receptor (NP_068576.1)

<400> 30
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          
Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 
Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     
Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             
Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 
Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 
Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     
Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         
Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             
Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 
Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 
Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     
Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         
Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             
Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 
Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 
Val Gln Thr Ser Phe 
                805 

<210> 31
<211> 250
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 6 to 255 of YP_009724390.1

<400> 31
Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn Leu Thr Thr Arg 
1               5                   10                  15      
Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr 
            20                  25                  30          
Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp 
        35                  40                  45              
Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His 
    50                  55                  60                  
Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro 
65                  70                  75                  80  
Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile 
                85                  90                  95      
Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu 
            100                 105                 110         
Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe 
        115                 120                 125             
Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn 
    130                 135                 140                 
Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 
Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     
Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         
Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val 
        195                 200                 205             
Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu 
    210                 215                 220                 
Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His 
225                 230                 235                 240 
Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
                245                 250 

<210> 32
<211> 145
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 111 to 255 of YP_009724390.1

<400> 32
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
1               5                   10                  15      
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
            20                  25                  30          
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
        35                  40                  45              
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
    50                  55                  60                  
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
65                  70                  75                  80  
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
                85                  90                  95      
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
            100                 105                 110         
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
        115                 120                 125             
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
    130                 135                 140                 
Ser 
145 

<210> 33
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 187 to 261 of YP_009724390.1

<400> 33
Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
1               5                   10                  15      
Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
            20                  25                  30          
Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
        35                  40                  45              
Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
    50                  55                  60                  
Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly 
65                  70                  75  

<210> 34
<211> 254
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 213 to 466 of YP_009724390.1

<400> 34
Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
1               5                   10                  15      
Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
            20                  25                  30          
His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
        35                  40                  45              
Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
    50                  55                  60                  
Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
65                  70                  75                  80  
Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
                85                  90                  95      
Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
            100                 105                 110         
Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
        115                 120                 125             
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
    130                 135                 140                 
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
145                 150                 155                 160 
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
                165                 170                 175     
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
            180                 185                 190         
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
        195                 200                 205             
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
    210                 215                 220                 
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
225                 230                 235                 240 
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
                245                 250                 

<210> 35
<211> 151
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 213 to 363 of YP_009724390.1

<400> 35
Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
1               5                   10                  15      
Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
            20                  25                  30          
His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
        35                  40                  45              
Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
    50                  55                  60                  
Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
65                  70                  75                  80  
Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
                85                  90                  95      
Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
            100                 105                 110         
Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
        115                 120                 125             
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
    130                 135                 140                 
Arg Ile Ser Asn Cys Val Ala 
145                 150     

<210> 36
<211> 295
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 289 to 583 of YP_009724390.1

<400> 36
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
1               5                   10                  15      
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
            20                  25                  30          
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
        35                  40                  45              
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
    50                  55                  60                  
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
65                  70                  75                  80  
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
                85                  90                  95      
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
            100                 105                 110         
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
        115                 120                 125             
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
    130                 135                 140                 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
145                 150                 155                 160 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
                165                 170                 175     
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
            180                 185                 190         
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
        195                 200                 205             
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
    210                 215                 220                 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
225                 230                 235                 240 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
                245                 250                 255     
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
            260                 265                 270         
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
        275                 280                 285             
Arg Asp Pro Gln Thr Leu Glu 
    290                 295 

<210> 37
<211> 259
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 300 to 558 of YP_009724390.1

<400> 37
Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
1               5                   10                  15      
Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            20                  25                  30          
Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        35                  40                  45              
Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    50                  55                  60                  
Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
65                  70                  75                  80  
Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                85                  90                  95      
Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            100                 105                 110         
Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        115                 120                 125             
Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    130                 135                 140                 
Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
145                 150                 155                 160 
Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                165                 170                 175     
Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            180                 185                 190         
Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
        195                 200                 205             
Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
    210                 215                 220                 
Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
225                 230                 235                 240 
Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
                245                 250                 255     
Asn Lys Lys 
            

<210> 38
<211> 208
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 300 to 507 of YP_009724390.1

<400> 38
Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
1               5                   10                  15      
Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            20                  25                  30          
Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        35                  40                  45              
Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    50                  55                  60                  
Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
65                  70                  75                  80  
Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                85                  90                  95      
Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            100                 105                 110         
Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        115                 120                 125             
Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    130                 135                 140                 
Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
145                 150                 155                 160 
Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                165                 170                 175     
Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            180                 185                 190         
Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
        195                 200                 205             



<210> 39
<211> 163
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 300 to 462 of YP_009724390.1

<400> 39
Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
1               5                   10                  15      
Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            20                  25                  30          
Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        35                  40                  45              
Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    50                  55                  60                  
Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
65                  70                  75                  80  
Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                85                  90                  95      
Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            100                 105                 110         
Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        115                 120                 125             
Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    130                 135                 140                 
Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
145                 150                 155                 160 
Asn Leu Lys 
            

<210> 40
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 293 to 367 of YP_009724390.1

<400> 40
Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
1               5                   10                  15      
Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
            20                  25                  30          
Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
        35                  40                  45              
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
    50                  55                  60                  
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
65                  70                  75  

<210> 41
<211> 258
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 659 to 916 of YP_009724390.1

<400> 41
Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
1               5                   10                  15      
Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln 
            20                  25                  30          
Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
        35                  40                  45              
Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
    50                  55                  60                  
Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
65                  70                  75                  80  
Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
                85                  90                  95      
Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
            100                 105                 110         
Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
        115                 120                 125             
Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
    130                 135                 140                 
Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
145                 150                 155                 160 
Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
                165                 170                 175     
Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
            180                 185                 190         
Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        195                 200                 205             
Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
    210                 215                 220                 
Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
225                 230                 235                 240 
Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                245                 250                 255     
Val Leu 
        

<210> 42
<211> 178
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 659 to 836 of YP_009724390.1

<400> 42
Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
1               5                   10                  15      
Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln 
            20                  25                  30          
Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
        35                  40                  45              
Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
    50                  55                  60                  
Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
65                  70                  75                  80  
Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
                85                  90                  95      
Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
            100                 105                 110         
Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
        115                 120                 125             
Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
    130                 135                 140                 
Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
145                 150                 155                 160 
Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
                165                 170                 175     
Lys Gln 
        

<210> 43
<211> 200
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 703 to 902 of YP_009724390.1

<400> 43
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
1               5                   10                  15      
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
            20                  25                  30          
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
        35                  40                  45              
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
    50                  55                  60                  
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
65                  70                  75                  80  
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
                85                  90                  95      
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
            100                 105                 110         
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
        115                 120                 125             
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
    130                 135                 140                 
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
145                 150                 155                 160 
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
                165                 170                 175     
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
            180                 185                 190         
Gln Ile Pro Phe Ala Met Gln Met 
        195                 200 

<210> 44
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 701 to 775 of YP_009724390.1

<400> 44
Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
1               5                   10                  15      
Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
            20                  25                  30          
Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
        35                  40                  45              
Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
    50                  55                  60                  
Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
65                  70                  75  

<210> 45
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 763 to 837 of YP_009724390.1

<400> 45
Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
1               5                   10                  15      
Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
            20                  25                  30          
Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
        35                  40                  45              
Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
    50                  55                  60                  
Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
65                  70                  75  

<210> 46
<211> 250
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 956 to 1205 of YP_009724390.1

<400> 46
Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
1               5                   10                  15      
Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            20                  25                  30          
Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
        35                  40                  45              
Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg 
    50                  55                  60                  
Ala Ser Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly 
65                  70                  75                  80  
Gln Ser Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser 
                85                  90                  95      
Phe Pro Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr 
            100                 105                 110         
Val Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 
        115                 120                 125             
Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly 
    130                 135                 140                 
Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile 
145                 150                 155                 160 
Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly 
                165                 170                 175     
Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser 
            180                 185                 190         
Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp 
        195                 200                 205             
Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile 
    210                 215                 220                 
Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu 
225                 230                 235                 240 
Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys 
                245                 250 

<210> 47
<211> 200
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 990 to 1189 of YP_009724390.1

<400> 47
Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
1               5                   10                  15      
Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
            20                  25                  30          
Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
        35                  40                  45              
Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
    50                  55                  60                  
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
65                  70                  75                  80  
Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
                85                  90                  95      
Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
            100                 105                 110         
Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
        115                 120                 125             
Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
    130                 135                 140                 
Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
145                 150                 155                 160 
Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
                165                 170                 175     
Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
            180                 185                 190         
Glu Ile Asp Arg Leu Asn Glu Val 
        195                 200 

<210> 48
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 949 to 1023 of YP_009724390.1

<400> 48
Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
1               5                   10                  15      
Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
            20                  25                  30          
Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
        35                  40                  45              
Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
    50                  55                  60                  
Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
65                  70                  75  

<210> 49
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 1038 to 1112 of YP_009724390.1

<400> 49
Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
1               5                   10                  15      
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
            20                  25                  30          
Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
        35                  40                  45              
Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
    50                  55                  60                  
Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro 
65                  70                  75  

<210> 50
<211> 78
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 1151 to 1228 of YP_009724390.1

<400> 50
Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu 
1               5                   10                  15      
Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu 
            20                  25                  30          
Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile 
        35                  40                  45              
Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp 
    50                  55                  60                  
Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val 
65                  70                  75              

<210> 51
<211> 419
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> SARS-CoV-2 N protein (YP_009724397.2)

<400> 51
Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      
Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          
Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              
Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  
Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  
Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      
Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         
Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             
Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 
His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 
Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     
Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         
Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             
Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 
Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 
Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     
Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         
Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             
Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 
Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 
Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     
Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         
Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             
Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 
Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 
Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     
Thr Gln Ala 
            

<210> 52
<211> 75
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> Coronavirus envelop protein (E protein) (YP_009724392.1)

<400> 52
Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 
1               5                   10                  15      
Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          
Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              
Val Ser Leu Val Lys Pro Ser Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  
Leu Asn Ser Ser Arg Val Pro Asp Leu Leu Val 
65                  70                  75  

<210> 53
<211> 222
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> Coronavirus membrane glycoprotein (M protein) (YP_009724393.1)

<400> 53
Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      
Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile 
            20                  25                  30          
Cys Leu Leu Gln Phe Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile 
        35                  40                  45              
Ile Lys Leu Ile Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys 
    50                  55                  60                  
Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile 
65                  70                  75                  80  
Ala Ile Ala Met Ala Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe 
                85                  90                  95      
Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe 
            100                 105                 110         
Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile 
        115                 120                 125             
Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile 
    130                 135                 140                 
Leu Arg Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp 
145                 150                 155                 160 
Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu 
                165                 170                 175     
Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly 
            180                 185                 190         
Phe Ala Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr 
        195                 200                 205             
Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220         

<210> 54
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp2) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 54
Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe Ser Ala Ser Thr Ser 
1               5                   10                  15  

<210> 55
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp2) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 55
Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu Cys Ala 
1               5                   10                  15  

<210> 56
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp4) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 56
Lys His Phe Tyr Trp Phe Phe Ser Asn Tyr Leu Lys Arg Arg Val 
1               5                   10                  15  

<210> 57
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp5) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 57
Asn His Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val 
1               5                   10                  15  

<210> 58
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp6) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 58
Asn Arg Tyr Phe Arg Leu Thr Leu Gly Val Tyr Asp Tyr Leu Val 
1               5                   10                  15  

<210> 59
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp12) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 59
Lys Leu Leu Lys Ser Ile Ala Ala Thr Arg Gly Ala Thr Val Val 
1               5                   10                  15  

<210> 60
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp13) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 60
Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg Ala Lys Val Gly 
1               5                   10                  15  

<210> 61
<211> 15
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> (nsp13) Epitope of the ORF1ab polyprotein (replicase complex)
      (YP_009724389.1)

<400> 61
Thr Ser His Lys Leu Val Leu Ser Val Asn Pro Tyr Val Cys Asn 
1               5                   10                  15  

<210> 62
<211> 291
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 434 to 724 of YP_009724389.1 (nsp2)

<400> 62
Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp Asn 
1               5                   10                  15      
Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val Gly 
            20                  25                  30          
Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe Ser 
        35                  40                  45              
Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr Lys 
    50                  55                  60                  
Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr Lys 
65                  70                  75                  80  
Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser Ile 
                85                  90                  95      
Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val Arg 
            100                 105                 110         
Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg Val 
        115                 120                 125             
Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr Ser 
    130                 135                 140                 
Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr Asn 
145                 150                 155                 160 
Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu Thr 
                165                 170                 175     
Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu Lys 
            180                 185                 190         
Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu Phe 
        195                 200                 205             
Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala Cys 
    210                 215                 220                 
Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys Glu 
225                 230                 235                 240 
Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu Cys 
                245                 250                 255     
Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn Leu 
            260                 265                 270         
Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys Val 
        275                 280                 285             
Lys Ser Arg 
    290     

<210> 63
<211> 289
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 3099 to 3387 of YP_009724389.1 (nsp4 and nsp5)

<400> 63
Ser Phe Leu Pro Gly Val Tyr Ser Val Ile Tyr Leu Tyr Leu Thr Phe 
1               5                   10                  15      
Tyr Leu Thr Asn Asp Val Ser Phe Leu Ala His Ile Gln Trp Met Val 
            20                  25                  30          
Met Phe Thr Pro Leu Val Pro Phe Trp Ile Thr Ile Ala Tyr Ile Ile 
        35                  40                  45              
Cys Ile Ser Thr Lys His Phe Tyr Trp Phe Phe Ser Asn Tyr Leu Lys 
    50                  55                  60                  
Arg Arg Val Val Phe Asn Gly Val Ser Phe Ser Thr Phe Glu Glu Ala 
65                  70                  75                  80  
Ala Leu Cys Thr Phe Leu Leu Asn Lys Glu Met Tyr Leu Lys Leu Arg 
                85                  90                  95      
Ser Asp Val Leu Leu Pro Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu 
            100                 105                 110         
Tyr Asn Lys Tyr Lys Tyr Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr 
        115                 120                 125             
Arg Glu Ala Ala Cys Cys His Leu Ala Lys Ala Leu Asn Asp Phe Ser 
    130                 135                 140                 
Asn Ser Gly Ser Asp Val Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr 
145                 150                 155                 160 
Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly 
                165                 170                 175     
Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu 
            180                 185                 190         
Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg His Val Ile 
        195                 200                 205             
Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile 
    210                 215                 220                 
Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu 
225                 230                 235                 240 
Arg Val Ile Gly His Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val 
                245                 250                 255     
Asp Thr Ala Asn Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln 
            260                 265                 270         
Pro Gly Gln Thr Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser 
        275                 280                 285             
Gly 
    

<210> 64
<211> 286
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 3617 to 3902 of YP_009724389.1 (nsp6)

<400> 64
Gly Ile Ile Ala Met Ser Ala Phe Ala Met Met Phe Val Lys His Lys 
1               5                   10                  15      
His Ala Phe Leu Cys Leu Phe Leu Leu Pro Ser Leu Ala Thr Val Ala 
            20                  25                  30          
Tyr Phe Asn Met Val Tyr Met Pro Ala Ser Trp Val Met Arg Ile Met 
        35                  40                  45              
Thr Trp Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys Leu Lys 
    50                  55                  60                  
Asp Cys Val Met Tyr Ala Ser Ala Val Val Leu Leu Ile Leu Met Thr 
65                  70                  75                  80  
Ala Arg Thr Val Tyr Asp Asp Gly Ala Arg Arg Val Trp Thr Leu Met 
                85                  90                  95      
Asn Val Leu Thr Leu Val Tyr Lys Val Tyr Tyr Gly Asn Ala Leu Asp 
            100                 105                 110         
Gln Ala Ile Ser Met Trp Ala Leu Ile Ile Ser Val Thr Ser Asn Tyr 
        115                 120                 125             
Ser Gly Val Val Thr Thr Val Met Phe Leu Ala Arg Gly Ile Val Phe 
    130                 135                 140                 
Met Cys Val Glu Tyr Cys Pro Ile Phe Phe Ile Thr Gly Asn Thr Leu 
145                 150                 155                 160 
Gln Cys Ile Met Leu Val Tyr Cys Phe Leu Gly Tyr Phe Cys Thr Cys 
                165                 170                 175     
Tyr Phe Gly Leu Phe Cys Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu 
            180                 185                 190         
Gly Val Tyr Asp Tyr Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn 
        195                 200                 205             
Ser Gln Gly Leu Leu Pro Pro Lys Asn Ser Ile Asp Ala Phe Lys Leu 
    210                 215                 220                 
Asn Ile Lys Leu Leu Gly Val Gly Gly Lys Pro Cys Ile Lys Val Ala 
225                 230                 235                 240 
Thr Val Gln Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu 
                245                 250                 255     
Leu Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp 
            260                 265                 270         
Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys 
        275                 280                 285     

<210> 65
<211> 283
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 4848 to 5130 of YP_009724389.1 (nsp12)

<400> 65
Tyr Arg Tyr Asn Leu Pro Thr Met Cys Asp Ile Arg Gln Leu Leu Phe 
1               5                   10                  15      
Val Val Glu Val Val Asp Lys Tyr Phe Asp Cys Tyr Asp Gly Gly Cys 
            20                  25                  30          
Ile Asn Ala Asn Gln Val Ile Val Asn Asn Leu Asp Lys Ser Ala Gly 
        35                  40                  45              
Phe Pro Phe Asn Lys Trp Gly Lys Ala Arg Leu Tyr Tyr Asp Ser Met 
    50                  55                  60                  
Ser Tyr Glu Asp Gln Asp Ala Leu Phe Ala Tyr Thr Lys Arg Asn Val 
65                  70                  75                  80  
Ile Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys 
                85                  90                  95      
Asn Arg Ala Arg Thr Val Ala Gly Val Ser Ile Cys Ser Thr Met Thr 
            100                 105                 110         
Asn Arg Gln Phe His Gln Lys Leu Leu Lys Ser Ile Ala Ala Thr Arg 
        115                 120                 125             
Gly Ala Thr Val Val Ile Gly Thr Ser Lys Phe Tyr Gly Gly Trp His 
    130                 135                 140                 
Asn Met Leu Lys Thr Val Tyr Ser Asp Val Glu Asn Pro His Leu Met 
145                 150                 155                 160 
Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Met Leu Arg 
                165                 170                 175     
Ile Met Ala Ser Leu Val Leu Ala Arg Lys His Thr Thr Cys Cys Ser 
            180                 185                 190         
Leu Ser His Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu 
        195                 200                 205             
Ser Glu Met Val Met Cys Gly Gly Ser Leu Tyr Val Lys Pro Gly Gly 
    210                 215                 220                 
Thr Ser Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn 
225                 230                 235                 240 
Ile Cys Gln Ala Val Thr Ala Asn Val Asn Ala Leu Leu Ser Thr Asp 
                245                 250                 255     
Gly Asn Lys Ile Ala Asp Lys Tyr Val Arg Asn Leu Gln His Arg Leu 
            260                 265                 270         
Tyr Glu Cys Leu Tyr Arg Asn Arg Asp Val Asp 
        275                 280             

<210> 66
<211> 289
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 5228 to 5516 of YP_009724389.1 (nsp13)

<400> 66
Arg Ile Leu Gly Ala Gly Cys Phe Val Asp Asp Ile Val Lys Thr Asp 
1               5                   10                  15      
Gly Thr Leu Met Ile Glu Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr 
            20                  25                  30          
Pro Leu Thr Lys His Pro Asn Gln Glu Tyr Ala Asp Val Phe His Leu 
        35                  40                  45              
Tyr Leu Gln Tyr Ile Arg Lys Leu His Asp Glu Leu Thr Gly His Met 
    50                  55                  60                  
Leu Asp Met Tyr Ser Val Met Leu Thr Asn Asp Asn Thr Ser Arg Tyr 
65                  70                  75                  80  
Trp Glu Pro Glu Phe Tyr Glu Ala Met Tyr Thr Pro His Thr Val Leu 
                85                  90                  95      
Gln Ala Val Gly Ala Cys Val Leu Cys Asn Ser Gln Thr Ser Leu Arg 
            100                 105                 110         
Cys Gly Ala Cys Ile Arg Arg Pro Phe Leu Cys Cys Lys Cys Cys Tyr 
        115                 120                 125             
Asp His Val Ile Ser Thr Ser His Lys Leu Val Leu Ser Val Asn Pro 
    130                 135                 140                 
Tyr Val Cys Asn Ala Pro Gly Cys Asp Val Thr Asp Val Thr Gln Leu 
145                 150                 155                 160 
Tyr Leu Gly Gly Met Ser Tyr Tyr Cys Lys Ser His Lys Pro Pro Ile 
                165                 170                 175     
Ser Phe Pro Leu Cys Ala Asn Gly Gln Val Phe Gly Leu Tyr Lys Asn 
            180                 185                 190         
Thr Cys Val Gly Ser Asp Asn Val Thr Asp Phe Asn Ala Ile Ala Thr 
        195                 200                 205             
Cys Asp Trp Thr Asn Ala Gly Asp Tyr Ile Leu Ala Asn Thr Cys Thr 
    210                 215                 220                 
Glu Arg Leu Lys Leu Phe Ala Ala Glu Thr Leu Lys Ala Thr Glu Glu 
225                 230                 235                 240 
Thr Phe Lys Leu Ser Tyr Gly Ile Ala Thr Val Arg Glu Val Leu Ser 
                245                 250                 255     
Asp Arg Glu Leu His Leu Ser Trp Glu Val Gly Lys Pro Arg Pro Pro 
            260                 265                 270         
Leu Asn Arg Asn Tyr Val Phe Thr Gly Tyr Arg Val Thr Lys Asn Ser 
        275                 280                 285             
Lys 
    

<210> 67
<211> 292
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 5732 to 6023 of YP_009724389.1 (nsp13)

<400> 67
Pro Arg Thr Leu Leu Thr Lys Gly Thr Leu Glu Pro Glu Tyr Phe Asn 
1               5                   10                  15      
Ser Val Cys Arg Leu Met Lys Thr Ile Gly Pro Asp Met Phe Leu Gly 
            20                  25                  30          
Thr Cys Arg Arg Cys Pro Ala Glu Ile Val Asp Thr Val Ser Ala Leu 
        35                  40                  45              
Val Tyr Asp Asn Lys Leu Lys Ala His Lys Asp Lys Ser Ala Gln Cys 
    50                  55                  60                  
Phe Lys Met Phe Tyr Lys Gly Val Ile Thr His Asp Val Ser Ser Ala 
65                  70                  75                  80  
Ile Asn Arg Pro Gln Ile Gly Val Val Arg Glu Phe Leu Thr Arg Asn 
                85                  90                  95      
Pro Ala Trp Arg Lys Ala Val Phe Ile Ser Pro Tyr Asn Ser Gln Asn 
            100                 105                 110         
Ala Val Ala Ser Lys Ile Leu Gly Leu Pro Thr Gln Thr Val Asp Ser 
        115                 120                 125             
Ser Gln Gly Ser Glu Tyr Asp Tyr Val Ile Phe Thr Gln Thr Thr Glu 
    130                 135                 140                 
Thr Ala His Ser Cys Asn Val Asn Arg Phe Asn Val Ala Ile Thr Arg 
145                 150                 155                 160 
Ala Lys Val Gly Ile Leu Cys Ile Met Ser Asp Arg Asp Leu Tyr Asp 
                165                 170                 175     
Lys Leu Gln Phe Thr Ser Leu Glu Ile Pro Arg Arg Asn Val Ala Thr 
            180                 185                 190         
Leu Gln Ala Glu Asn Val Thr Gly Leu Phe Lys Asp Cys Ser Lys Val 
        195                 200                 205             
Ile Thr Gly Leu His Pro Thr Gln Ala Pro Thr His Leu Ser Val Asp 
    210                 215                 220                 
Thr Lys Phe Lys Thr Glu Gly Leu Cys Val Asp Ile Pro Gly Ile Pro 
225                 230                 235                 240 
Lys Asp Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly Phe Lys Met 
                245                 250                 255     
Asn Tyr Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr Arg Glu Glu 
            260                 265                 270         
Ala Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val Glu Gly Cys 
        275                 280                 285             
His Ala Thr Arg 
    290         

<210> 68
<211> 7096
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> Coronavirus membrane glycoprotein ORF1ab polyprotein (replicase
      complex) (YP_009724389.1)

<400> 68
Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu 
1               5                   10                  15      
Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly 
            20                  25                  30          
Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp 
        35                  40                  45              
Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu 
    50                  55                  60                  
Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro 
65                  70                  75                  80  
His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln 
                85                  90                  95      
Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly 
            100                 105                 110         
Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn 
        115                 120                 125             
Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp 
    130                 135                 140                 
Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn 
145                 150                 155                 160 
Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu 
                165                 170                 175     
Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly 
            180                 185                 190         
Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala 
        195                 200                 205             
Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr 
    210                 215                 220                 
Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp 
225                 230                 235                 240 
Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu 
                245                 250                 255     
Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn 
            260                 265                 270         
Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val 
        275                 280                 285             
Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr 
    290                 295                 300                 
Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu 
305                 310                 315                 320 
Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe 
                325                 330                 335     
Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu 
            340                 345                 350         
Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile 
        355                 360                 365             
Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu 
    370                 375                 380                 
Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly 
385                 390                 395                 400 
Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys 
                405                 410                 415     
His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly 
            420                 425                 430         
Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp 
        435                 440                 445             
Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val 
    450                 455                 460                 
Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe 
465                 470                 475                 480 
Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr 
                485                 490                 495     
Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr 
            500                 505                 510         
Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser 
        515                 520                 525             
Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val 
    530                 535                 540                 
Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg 
545                 550                 555                 560 
Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr 
                565                 570                 575     
Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr 
            580                 585                 590         
Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu 
        595                 600                 605             
Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu 
    610                 615                 620                 
Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu 
625                 630                 635                 640 
Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala 
                645                 650                 655     
Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys 
            660                 665                 670         
Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu 
        675                 680                 685             
Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn 
    690                 695                 700                 
Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys 
705                 710                 715                 720 
Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro 
                725                 730                 735     
Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu 
            740                 745                 750         
Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln 
        755                 760                 765             
Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys 
    770                 775                 780                 
Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys 
785                 790                 795                 800 
Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys 
                805                 810                 815     
Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu 
            820                 825                 830         
Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg 
        835                 840                 845             
Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu 
    850                 855                 860                 
Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile 
865                 870                 875                 880 
Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp 
                885                 890                 895     
Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly 
            900                 905                 910         
Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp 
        915                 920                 925             
Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser 
    930                 935                 940                 
Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu 
945                 950                 955                 960 
Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu 
                965                 970                 975     
Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp 
            980                 985                 990         
Gly Ser Glu Asp Asn Gln Thr Thr Thr Ile Gln Thr Ile Val Glu Val 
        995                 1000                1005            
Gln Pro Gln Leu Glu Met Glu Leu Thr Pro Val Val Gln Thr Ile Glu 
    1010                1015                1020                
Val Asn Ser Phe Ser Gly Tyr Leu Lys Leu Thr Asp Asn Val Tyr Ile 
1025                1030                1035                1040
Lys Asn Ala Asp Ile Val Glu Glu Ala Lys Lys Val Lys Pro Thr Val 
                1045                1050                1055    
Val Val Asn Ala Ala Asn Val Tyr Leu Lys His Gly Gly Gly Val Ala 
            1060                1065                1070        
Gly Ala Leu Asn Lys Ala Thr Asn Asn Ala Met Gln Val Glu Ser Asp 
        1075                1080                1085            
Asp Tyr Ile Ala Thr Asn Gly Pro Leu Lys Val Gly Gly Ser Cys Val 
    1090                1095                1100                
Leu Ser Gly His Asn Leu Ala Lys His Cys Leu His Val Val Gly Pro 
1105                1110                1115                1120
Asn Val Asn Lys Gly Glu Asp Ile Gln Leu Leu Lys Ser Ala Tyr Glu 
                1125                1130                1135    
Asn Phe Asn Gln His Glu Val Leu Leu Ala Pro Leu Leu Ser Ala Gly 
            1140                1145                1150        
Ile Phe Gly Ala Asp Pro Ile His Ser Leu Arg Val Cys Val Asp Thr 
        1155                1160                1165            
Val Arg Thr Asn Val Tyr Leu Ala Val Phe Asp Lys Asn Leu Tyr Asp 
    1170                1175                1180                
Lys Leu Val Ser Ser Phe Leu Glu Met Lys Ser Glu Lys Gln Val Glu 
1185                1190                1195                1200
Gln Lys Ile Ala Glu Ile Pro Lys Glu Glu Val Lys Pro Phe Ile Thr 
                1205                1210                1215    
Glu Ser Lys Pro Ser Val Glu Gln Arg Lys Gln Asp Asp Lys Lys Ile 
            1220                1225                1230        
Lys Ala Cys Val Glu Glu Val Thr Thr Thr Leu Glu Glu Thr Lys Phe 
        1235                1240                1245            
Leu Thr Glu Asn Leu Leu Leu Tyr Ile Asp Ile Asn Gly Asn Leu His 
    1250                1255                1260                
Pro Asp Ser Ala Thr Leu Val Ser Asp Ile Asp Ile Thr Phe Leu Lys 
1265                1270                1275                1280
Lys Asp Ala Pro Tyr Ile Val Gly Asp Val Val Gln Glu Gly Val Leu 
                1285                1290                1295    
Thr Ala Val Val Ile Pro Thr Lys Lys Ala Gly Gly Thr Thr Glu Met 
            1300                1305                1310        
Leu Ala Lys Ala Leu Arg Lys Val Pro Thr Asp Asn Tyr Ile Thr Thr 
        1315                1320                1325            
Tyr Pro Gly Gln Gly Leu Asn Gly Tyr Thr Val Glu Glu Ala Lys Thr 
    1330                1335                1340                
Val Leu Lys Lys Cys Lys Ser Ala Phe Tyr Ile Leu Pro Ser Ile Ile 
1345                1350                1355                1360
Ser Asn Glu Lys Gln Glu Ile Leu Gly Thr Val Ser Trp Asn Leu Arg 
                1365                1370                1375    
Glu Met Leu Ala His Ala Glu Glu Thr Arg Lys Leu Met Pro Val Cys 
            1380                1385                1390        
Val Glu Thr Lys Ala Ile Val Ser Thr Ile Gln Arg Lys Tyr Lys Gly 
        1395                1400                1405            
Ile Lys Ile Gln Glu Gly Val Val Asp Tyr Gly Ala Arg Phe Tyr Phe 
    1410                1415                1420                
Tyr Thr Ser Lys Thr Thr Val Ala Ser Leu Ile Asn Thr Leu Asn Asp 
1425                1430                1435                1440
Leu Asn Glu Thr Leu Val Thr Met Pro Leu Gly Tyr Val Thr His Gly 
                1445                1450                1455    
Leu Asn Leu Glu Glu Ala Ala Arg Tyr Met Arg Ser Leu Lys Val Pro 
            1460                1465                1470        
Ala Thr Val Ser Val Ser Ser Pro Asp Ala Val Thr Ala Tyr Asn Gly 
        1475                1480                1485            
Tyr Leu Thr Ser Ser Ser Lys Thr Pro Glu Glu His Phe Ile Glu Thr 
    1490                1495                1500                
Ile Ser Leu Ala Gly Ser Tyr Lys Asp Trp Ser Tyr Ser Gly Gln Ser 
1505                1510                1515                1520
Thr Gln Leu Gly Ile Glu Phe Leu Lys Arg Gly Asp Lys Ser Val Tyr 
                1525                1530                1535    
Tyr Thr Ser Asn Pro Thr Thr Phe His Leu Asp Gly Glu Val Ile Thr 
            1540                1545                1550        
Phe Asp Asn Leu Lys Thr Leu Leu Ser Leu Arg Glu Val Arg Thr Ile 
        1555                1560                1565            
Lys Val Phe Thr Thr Val Asp Asn Ile Asn Leu His Thr Gln Val Val 
    1570                1575                1580                
Asp Met Ser Met Thr Tyr Gly Gln Gln Phe Gly Pro Thr Tyr Leu Asp 
1585                1590                1595                1600
Gly Ala Asp Val Thr Lys Ile Lys Pro His Asn Ser His Glu Gly Lys 
                1605                1610                1615    
Thr Phe Tyr Val Leu Pro Asn Asp Asp Thr Leu Arg Val Glu Ala Phe 
            1620                1625                1630        
Glu Tyr Tyr His Thr Thr Asp Pro Ser Phe Leu Gly Arg Tyr Met Ser 
        1635                1640                1645            
Ala Leu Asn His Thr Lys Lys Trp Lys Tyr Pro Gln Val Asn Gly Leu 
    1650                1655                1660                
Thr Ser Ile Lys Trp Ala Asp Asn Asn Cys Tyr Leu Ala Thr Ala Leu 
1665                1670                1675                1680
Leu Thr Leu Gln Gln Ile Glu Leu Lys Phe Asn Pro Pro Ala Leu Gln 
                1685                1690                1695    
Asp Ala Tyr Tyr Arg Ala Arg Ala Gly Glu Ala Ala Asn Phe Cys Ala 
            1700                1705                1710        
Leu Ile Leu Ala Tyr Cys Asn Lys Thr Val Gly Glu Leu Gly Asp Val 
        1715                1720                1725            
Arg Glu Thr Met Ser Tyr Leu Phe Gln His Ala Asn Leu Asp Ser Cys 
    1730                1735                1740                
Lys Arg Val Leu Asn Val Val Cys Lys Thr Cys Gly Gln Gln Gln Thr 
1745                1750                1755                1760
Thr Leu Lys Gly Val Glu Ala Val Met Tyr Met Gly Thr Leu Ser Tyr 
                1765                1770                1775    
Glu Gln Phe Lys Lys Gly Val Gln Ile Pro Cys Thr Cys Gly Lys Gln 
            1780                1785                1790        
Ala Thr Lys Tyr Leu Val Gln Gln Glu Ser Pro Phe Val Met Met Ser 
        1795                1800                1805            
Ala Pro Pro Ala Gln Tyr Glu Leu Lys His Gly Thr Phe Thr Cys Ala 
    1810                1815                1820                
Ser Glu Tyr Thr Gly Asn Tyr Gln Cys Gly His Tyr Lys His Ile Thr 
1825                1830                1835                1840
Ser Lys Glu Thr Leu Tyr Cys Ile Asp Gly Ala Leu Leu Thr Lys Ser 
                1845                1850                1855    
Ser Glu Tyr Lys Gly Pro Ile Thr Asp Val Phe Tyr Lys Glu Asn Ser 
            1860                1865                1870        
Tyr Thr Thr Thr Ile Lys Pro Val Thr Tyr Lys Leu Asp Gly Val Val 
        1875                1880                1885            
Cys Thr Glu Ile Asp Pro Lys Leu Asp Asn Tyr Tyr Lys Lys Asp Asn 
    1890                1895                1900                
Ser Tyr Phe Thr Glu Gln Pro Ile Asp Leu Val Pro Asn Gln Pro Tyr 
1905                1910                1915                1920
Pro Asn Ala Ser Phe Asp Asn Phe Lys Phe Val Cys Asp Asn Ile Lys 
                1925                1930                1935    
Phe Ala Asp Asp Leu Asn Gln Leu Thr Gly Tyr Lys Lys Pro Ala Ser 
            1940                1945                1950        
Arg Glu Leu Lys Val Thr Phe Phe Pro Asp Leu Asn Gly Asp Val Val 
        1955                1960                1965            
Ala Ile Asp Tyr Lys His Tyr Thr Pro Ser Phe Lys Lys Gly Ala Lys 
    1970                1975                1980                
Leu Leu His Lys Pro Ile Val Trp His Val Asn Asn Ala Thr Asn Lys 
1985                1990                1995                2000
Ala Thr Tyr Lys Pro Asn Thr Trp Cys Ile Arg Cys Leu Trp Ser Thr 
                2005                2010                2015    
Lys Pro Val Glu Thr Ser Asn Ser Phe Asp Val Leu Lys Ser Glu Asp 
            2020                2025                2030        
Ala Gln Gly Met Asp Asn Leu Ala Cys Glu Asp Leu Lys Pro Val Ser 
        2035                2040                2045            
Glu Glu Val Val Glu Asn Pro Thr Ile Gln Lys Asp Val Leu Glu Cys 
    2050                2055                2060                
Asn Val Lys Thr Thr Glu Val Val Gly Asp Ile Ile Leu Lys Pro Ala 
2065                2070                2075                2080
Asn Asn Ser Leu Lys Ile Thr Glu Glu Val Gly His Thr Asp Leu Met 
                2085                2090                2095    
Ala Ala Tyr Val Asp Asn Ser Ser Leu Thr Ile Lys Lys Pro Asn Glu 
            2100                2105                2110        
Leu Ser Arg Val Leu Gly Leu Lys Thr Leu Ala Thr His Gly Leu Ala 
        2115                2120                2125            
Ala Val Asn Ser Val Pro Trp Asp Thr Ile Ala Asn Tyr Ala Lys Pro 
    2130                2135                2140                
Phe Leu Asn Lys Val Val Ser Thr Thr Thr Asn Ile Val Thr Arg Cys 
2145                2150                2155                2160
Leu Asn Arg Val Cys Thr Asn Tyr Met Pro Tyr Phe Phe Thr Leu Leu 
                2165                2170                2175    
Leu Gln Leu Cys Thr Phe Thr Arg Ser Thr Asn Ser Arg Ile Lys Ala 
            2180                2185                2190        
Ser Met Pro Thr Thr Ile Ala Lys Asn Thr Val Lys Ser Val Gly Lys 
        2195                2200                2205            
Phe Cys Leu Glu Ala Ser Phe Asn Tyr Leu Lys Ser Pro Asn Phe Ser 
    2210                2215                2220                
Lys Leu Ile Asn Ile Ile Ile Trp Phe Leu Leu Leu Ser Val Cys Leu 
2225                2230                2235                2240
Gly Ser Leu Ile Tyr Ser Thr Ala Ala Leu Gly Val Leu Met Ser Asn 
                2245                2250                2255    
Leu Gly Met Pro Ser Tyr Cys Thr Gly Tyr Arg Glu Gly Tyr Leu Asn 
            2260                2265                2270        
Ser Thr Asn Val Thr Ile Ala Thr Tyr Cys Thr Gly Ser Ile Pro Cys 
        2275                2280                2285            
Ser Val Cys Leu Ser Gly Leu Asp Ser Leu Asp Thr Tyr Pro Ser Leu 
    2290                2295                2300                
Glu Thr Ile Gln Ile Thr Ile Ser Ser Phe Lys Trp Asp Leu Thr Ala 
2305                2310                2315                2320
Phe Gly Leu Val Ala Glu Trp Phe Leu Ala Tyr Ile Leu Phe Thr Arg 
                2325                2330                2335    
Phe Phe Tyr Val Leu Gly Leu Ala Ala Ile Met Gln Leu Phe Phe Ser 
            2340                2345                2350        
Tyr Phe Ala Val His Phe Ile Ser Asn Ser Trp Leu Met Trp Leu Ile 
        2355                2360                2365            
Ile Asn Leu Val Gln Met Ala Pro Ile Ser Ala Met Val Arg Met Tyr 
    2370                2375                2380                
Ile Phe Phe Ala Ser Phe Tyr Tyr Val Trp Lys Ser Tyr Val His Val 
2385                2390                2395                2400
Val Asp Gly Cys Asn Ser Ser Thr Cys Met Met Cys Tyr Lys Arg Asn 
                2405                2410                2415    
Arg Ala Thr Arg Val Glu Cys Thr Thr Ile Val Asn Gly Val Arg Arg 
            2420                2425                2430        
Ser Phe Tyr Val Tyr Ala Asn Gly Gly Lys Gly Phe Cys Lys Leu His 
        2435                2440                2445            
Asn Trp Asn Cys Val Asn Cys Asp Thr Phe Cys Ala Gly Ser Thr Phe 
    2450                2455                2460                
Ile Ser Asp Glu Val Ala Arg Asp Leu Ser Leu Gln Phe Lys Arg Pro 
2465                2470                2475                2480
Ile Asn Pro Thr Asp Gln Ser Ser Tyr Ile Val Asp Ser Val Thr Val 
                2485                2490                2495    
Lys Asn Gly Ser Ile His Leu Tyr Phe Asp Lys Ala Gly Gln Lys Thr 
            2500                2505                2510        
Tyr Glu Arg His Ser Leu Ser His Phe Val Asn Leu Asp Asn Leu Arg 
        2515                2520                2525            
Ala Asn Asn Thr Lys Gly Ser Leu Pro Ile Asn Val Ile Val Phe Asp 
    2530                2535                2540                
Gly Lys Ser Lys Cys Glu Glu Ser Ser Ala Lys Ser Ala Ser Val Tyr 
2545                2550                2555                2560
Tyr Ser Gln Leu Met Cys Gln Pro Ile Leu Leu Leu Asp Gln Ala Leu 
                2565                2570                2575    
Val Ser Asp Val Gly Asp Ser Ala Glu Val Ala Val Lys Met Phe Asp 
            2580                2585                2590        
Ala Tyr Val Asn Thr Phe Ser Ser Thr Phe Asn Val Pro Met Glu Lys 
        2595                2600                2605            
Leu Lys Thr Leu Val Ala Thr Ala Glu Ala Glu Leu Ala Lys Asn Val 
    2610                2615                2620                
Ser Leu Asp Asn Val Leu Ser Thr Phe Ile Ser Ala Ala Arg Gln Gly 
2625                2630                2635                2640
Phe Val Asp Ser Asp Val Glu Thr Lys Asp Val Val Glu Cys Leu Lys 
                2645                2650                2655    
Leu Ser His Gln Ser Asp Ile Glu Val Thr Gly Asp Ser Cys Asn Asn 
            2660                2665                2670        
Tyr Met Leu Thr Tyr Asn Lys Val Glu Asn Met Thr Pro Arg Asp Leu 
        2675                2680                2685            
Gly Ala Cys Ile Asp Cys Ser Ala Arg His Ile Asn Ala Gln Val Ala 
    2690                2695                2700                
Lys Ser His Asn Ile Ala Leu Ile Trp Asn Val Lys Asp Phe Met Ser 
2705                2710                2715                2720
Leu Ser Glu Gln Leu Arg Lys Gln Ile Arg Ser Ala Ala Lys Lys Asn 
                2725                2730                2735    
Asn Leu Pro Phe Lys Leu Thr Cys Ala Thr Thr Arg Gln Val Val Asn 
            2740                2745                2750        
Val Val Thr Thr Lys Ile Ala Leu Lys Gly Gly Lys Ile Val Asn Asn 
        2755                2760                2765            
Trp Leu Lys Gln Leu Ile Lys Val Thr Leu Val Phe Leu Phe Val Ala 
    2770                2775                2780                
Ala Ile Phe Tyr Leu Ile Thr Pro Val His Val Met Ser Lys His Thr 
2785                2790                2795                2800
Asp Phe Ser Ser Glu Ile Ile Gly Tyr Lys Ala Ile Asp Gly Gly Val 
                2805                2810                2815    
Thr Arg Asp Ile Ala Ser Thr Asp Thr Cys Phe Ala Asn Lys His Ala 
            2820                2825                2830        
Asp Phe Asp Thr Trp Phe Ser Gln Arg Gly Gly Ser Tyr Thr Asn Asp 
        2835                2840                2845            
Lys Ala Cys Pro Leu Ile Ala Ala Val Ile Thr Arg Glu Val Gly Phe 
    2850                2855                2860                
Val Val Pro Gly Leu Pro Gly Thr Ile Leu Arg Thr Thr Asn Gly Asp 
2865                2870                2875                2880
Phe Leu His Phe Leu Pro Arg Val Phe Ser Ala Val Gly Asn Ile Cys 
                2885                2890                2895    
Tyr Thr Pro Ser Lys Leu Ile Glu Tyr Thr Asp Phe Ala Thr Ser Ala 
            2900                2905                2910        
Cys Val Leu Ala Ala Glu Cys Thr Ile Phe Lys Asp Ala Ser Gly Lys 
        2915                2920                2925            
Pro Val Pro Tyr Cys Tyr Asp Thr Asn Val Leu Glu Gly Ser Val Ala 
    2930                2935                2940                
Tyr Glu Ser Leu Arg Pro Asp Thr Arg Tyr Val Leu Met Asp Gly Ser 
2945                2950                2955                2960
Ile Ile Gln Phe Pro Asn Thr Tyr Leu Glu Gly Ser Val Arg Val Val 
                2965                2970                2975    
Thr Thr Phe Asp Ser Glu Tyr Cys Arg His Gly Thr Cys Glu Arg Ser 
            2980                2985                2990        
Glu Ala Gly Val Cys Val Ser Thr Ser Gly Arg Trp Val Leu Asn Asn 
        2995                3000                3005            
Asp Tyr Tyr Arg Ser Leu Pro Gly Val Phe Cys Gly Val Asp Ala Val 
    3010                3015                3020                
Asn Leu Leu Thr Asn Met Phe Thr Pro Leu Ile Gln Pro Ile Gly Ala 
3025                3030                3035                3040
Leu Asp Ile Ser Ala Ser Ile Val Ala Gly Gly Ile Val Ala Ile Val 
                3045                3050                3055    
Val Thr Cys Leu Ala Tyr Tyr Phe Met Arg Phe Arg Arg Ala Phe Gly 
            3060                3065                3070        
Glu Tyr Ser His Val Val Ala Phe Asn Thr Leu Leu Phe Leu Met Ser 
        3075                3080                3085            
Phe Thr Val Leu Cys Leu Thr Pro Val Tyr Ser Phe Leu Pro Gly Val 
    3090                3095                3100                
Tyr Ser Val Ile Tyr Leu Tyr Leu Thr Phe Tyr Leu Thr Asn Asp Val 
3105                3110                3115                3120
Ser Phe Leu Ala His Ile Gln Trp Met Val Met Phe Thr Pro Leu Val 
                3125                3130                3135    
Pro Phe Trp Ile Thr Ile Ala Tyr Ile Ile Cys Ile Ser Thr Lys His 
            3140                3145                3150        
Phe Tyr Trp Phe Phe Ser Asn Tyr Leu Lys Arg Arg Val Val Phe Asn 
        3155                3160                3165            
Gly Val Ser Phe Ser Thr Phe Glu Glu Ala Ala Leu Cys Thr Phe Leu 
    3170                3175                3180                
Leu Asn Lys Glu Met Tyr Leu Lys Leu Arg Ser Asp Val Leu Leu Pro 
3185                3190                3195                3200
Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu Tyr Asn Lys Tyr Lys Tyr 
                3205                3210                3215    
Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr Arg Glu Ala Ala Cys Cys 
            3220                3225                3230        
His Leu Ala Lys Ala Leu Asn Asp Phe Ser Asn Ser Gly Ser Asp Val 
        3235                3240                3245            
Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr Ser Ala Val Leu Gln Ser 
    3250                3255                3260                
Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys Met 
3265                3270                3275                3280
Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu Asp 
                3285                3290                3295    
Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp Met 
            3300                3305                3310        
Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His Asn 
        3315                3320                3325            
Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His Ser 
    3330                3335                3340                
Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro Lys 
3345                3350                3355                3360
Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe Ser 
                3365                3370                3375    
Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala 
            3380                3385                3390        
Met Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys 
        3395                3400                3405            
Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys Tyr 
    3410                3415                3420                
Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp Leu 
3425                3430                3435                3440
Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln Ala 
                3445                3450                3455    
Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu Tyr 
            3460                3465                3470        
Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr Thr 
        3475                3480                3485            
Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro 
    3490                3495                3500                
Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr 
3505                3510                3515                3520
Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln 
                3525                3530                3535    
Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp 
            3540                3545                3550        
Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe 
        3555                3560                3565            
Gln Ser Ala Val Lys Arg Thr Ile Lys Gly Thr His His Trp Leu Leu 
    3570                3575                3580                
Leu Thr Ile Leu Thr Ser Leu Leu Val Leu Val Gln Ser Thr Gln Trp 
3585                3590                3595                3600
Ser Leu Phe Phe Phe Leu Tyr Glu Asn Ala Phe Leu Pro Phe Ala Met 
                3605                3610                3615    
Gly Ile Ile Ala Met Ser Ala Phe Ala Met Met Phe Val Lys His Lys 
            3620                3625                3630        
His Ala Phe Leu Cys Leu Phe Leu Leu Pro Ser Leu Ala Thr Val Ala 
        3635                3640                3645            
Tyr Phe Asn Met Val Tyr Met Pro Ala Ser Trp Val Met Arg Ile Met 
    3650                3655                3660                
Thr Trp Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys Leu Lys 
3665                3670                3675                3680
Asp Cys Val Met Tyr Ala Ser Ala Val Val Leu Leu Ile Leu Met Thr 
                3685                3690                3695    
Ala Arg Thr Val Tyr Asp Asp Gly Ala Arg Arg Val Trp Thr Leu Met 
            3700                3705                3710        
Asn Val Leu Thr Leu Val Tyr Lys Val Tyr Tyr Gly Asn Ala Leu Asp 
        3715                3720                3725            
Gln Ala Ile Ser Met Trp Ala Leu Ile Ile Ser Val Thr Ser Asn Tyr 
    3730                3735                3740                
Ser Gly Val Val Thr Thr Val Met Phe Leu Ala Arg Gly Ile Val Phe 
3745                3750                3755                3760
Met Cys Val Glu Tyr Cys Pro Ile Phe Phe Ile Thr Gly Asn Thr Leu 
                3765                3770                3775    
Gln Cys Ile Met Leu Val Tyr Cys Phe Leu Gly Tyr Phe Cys Thr Cys 
            3780                3785                3790        
Tyr Phe Gly Leu Phe Cys Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu 
        3795                3800                3805            
Gly Val Tyr Asp Tyr Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn 
    3810                3815                3820                
Ser Gln Gly Leu Leu Pro Pro Lys Asn Ser Ile Asp Ala Phe Lys Leu 
3825                3830                3835                3840
Asn Ile Lys Leu Leu Gly Val Gly Gly Lys Pro Cys Ile Lys Val Ala 
                3845                3850                3855    
Thr Val Gln Ser Lys Met Ser Asp Val Lys Cys Thr Ser Val Val Leu 
            3860                3865                3870        
Leu Ser Val Leu Gln Gln Leu Arg Val Glu Ser Ser Ser Lys Leu Trp 
        3875                3880                3885            
Ala Gln Cys Val Gln Leu His Asn Asp Ile Leu Leu Ala Lys Asp Thr 
    3890                3895                3900                
Thr Glu Ala Phe Glu Lys Met Val Ser Leu Leu Ser Val Leu Leu Ser 
3905                3910                3915                3920
Met Gln Gly Ala Val Asp Ile Asn Lys Leu Cys Glu Glu Met Leu Asp 
                3925                3930                3935    
Asn Arg Ala Thr Leu Gln Ala Ile Ala Ser Glu Phe Ser Ser Leu Pro 
            3940                3945                3950        
Ser Tyr Ala Ala Phe Ala Thr Ala Gln Glu Ala Tyr Glu Gln Ala Val 
        3955                3960                3965            
Ala Asn Gly Asp Ser Glu Val Val Leu Lys Lys Leu Lys Lys Ser Leu 
    3970                3975                3980                
Asn Val Ala Lys Ser Glu Phe Asp Arg Asp Ala Ala Met Gln Arg Lys 
3985                3990                3995                4000
Leu Glu Lys Met Ala Asp Gln Ala Met Thr Gln Met Tyr Lys Gln Ala 
                4005                4010                4015    
Arg Ser Glu Asp Lys Arg Ala Lys Val Thr Ser Ala Met Gln Thr Met 
            4020                4025                4030        
Leu Phe Thr Met Leu Arg Lys Leu Asp Asn Asp Ala Leu Asn Asn Ile 
        4035                4040                4045            
Ile Asn Asn Ala Arg Asp Gly Cys Val Pro Leu Asn Ile Ile Pro Leu 
    4050                4055                4060                
Thr Thr Ala Ala Lys Leu Met Val Val Ile Pro Asp Tyr Asn Thr Tyr 
4065                4070                4075                4080
Lys Asn Thr Cys Asp Gly Thr Thr Phe Thr Tyr Ala Ser Ala Leu Trp 
                4085                4090                4095    
Glu Ile Gln Gln Val Val Asp Ala Asp Ser Lys Ile Val Gln Leu Ser 
            4100                4105                4110        
Glu Ile Ser Met Asp Asn Ser Pro Asn Leu Ala Trp Pro Leu Ile Val 
        4115                4120                4125            
Thr Ala Leu Arg Ala Asn Ser Ala Val Lys Leu Gln Asn Asn Glu Leu 
    4130                4135                4140                
Ser Pro Val Ala Leu Arg Gln Met Ser Cys Ala Ala Gly Thr Thr Gln 
4145                4150                4155                4160
Thr Ala Cys Thr Asp Asp Asn Ala Leu Ala Tyr Tyr Asn Thr Thr Lys 
                4165                4170                4175    
Gly Gly Arg Phe Val Leu Ala Leu Leu Ser Asp Leu Gln Asp Leu Lys 
            4180                4185                4190        
Trp Ala Arg Phe Pro Lys Ser Asp Gly Thr Gly Thr Ile Tyr Thr Glu 
        4195                4200                4205            
Leu Glu Pro Pro Cys Arg Phe Val Thr Asp Thr Pro Lys Gly Pro Lys 
    4210                4215                4220                
Val Lys Tyr Leu Tyr Phe Ile Lys Gly Leu Asn Asn Leu Asn Arg Gly 
4225                4230                4235                4240
Met Val Leu Gly Ser Leu Ala Ala Thr Val Arg Leu Gln Ala Gly Asn 
                4245                4250                4255    
Ala Thr Glu Val Pro Ala Asn Ser Thr Val Leu Ser Phe Cys Ala Phe 
            4260                4265                4270        
Ala Val Asp Ala Ala Lys Ala Tyr Lys Asp Tyr Leu Ala Ser Gly Gly 
        4275                4280                4285            
Gln Pro Ile Thr Asn Cys Val Lys Met Leu Cys Thr His Thr Gly Thr 
    4290                4295                4300                
Gly Gln Ala Ile Thr Val Thr Pro Glu Ala Asn Met Asp Gln Glu Ser 
4305                4310                4315                4320
Phe Gly Gly Ala Ser Cys Cys Leu Tyr Cys Arg Cys His Ile Asp His 
                4325                4330                4335    
Pro Asn Pro Lys Gly Phe Cys Asp Leu Lys Gly Lys Tyr Val Gln Ile 
            4340                4345                4350        
Pro Thr Thr Cys Ala Asn Asp Pro Val Gly Phe Thr Leu Lys Asn Thr 
        4355                4360                4365            
Val Cys Thr Val Cys Gly Met Trp Lys Gly Tyr Gly Cys Ser Cys Asp 
    4370                4375                4380                
Gln Leu Arg Glu Pro Met Leu Gln Ser Ala Asp Ala Gln Ser Phe Leu 
4385                4390                4395                4400
Asn Arg Val Cys Gly Val Ser Ala Ala Arg Leu Thr Pro Cys Gly Thr 
                4405                4410                4415    
Gly Thr Ser Thr Asp Val Val Tyr Arg Ala Phe Asp Ile Tyr Asn Asp 
            4420                4425                4430        
Lys Val Ala Gly Phe Ala Lys Phe Leu Lys Thr Asn Cys Cys Arg Phe 
        4435                4440                4445            
Gln Glu Lys Asp Glu Asp Asp Asn Leu Ile Asp Ser Tyr Phe Val Val 
    4450                4455                4460                
Lys Arg His Thr Phe Ser Asn Tyr Gln His Glu Glu Thr Ile Tyr Asn 
4465                4470                4475                4480
Leu Leu Lys Asp Cys Pro Ala Val Ala Lys His Asp Phe Phe Lys Phe 
                4485                4490                4495    
Arg Ile Asp Gly Asp Met Val Pro His Ile Ser Arg Gln Arg Leu Thr 
            4500                4505                4510        
Lys Tyr Thr Met Ala Asp Leu Val Tyr Ala Leu Arg His Phe Asp Glu 
        4515                4520                4525            
Gly Asn Cys Asp Thr Leu Lys Glu Ile Leu Val Thr Tyr Asn Cys Cys 
    4530                4535                4540                
Asp Asp Asp Tyr Phe Asn Lys Lys Asp Trp Tyr Asp Phe Val Glu Asn 
4545                4550                4555                4560
Pro Asp Ile Leu Arg Val Tyr Ala Asn Leu Gly Glu Arg Val Arg Gln 
                4565                4570                4575    
Ala Leu Leu Lys Thr Val Gln Phe Cys Asp Ala Met Arg Asn Ala Gly 
            4580                4585                4590        
Ile Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu Asn Gly Asn Trp 
        4595                4600                4605            
Tyr Asp Phe Gly Asp Phe Ile Gln Thr Thr Pro Gly Ser Gly Val Pro 
    4610                4615                4620                
Val Val Asp Ser Tyr Tyr Ser Leu Leu Met Pro Ile Leu Thr Leu Thr 
4625                4630                4635                4640
Arg Ala Leu Thr Ala Glu Ser His Val Asp Thr Asp Leu Thr Lys Pro 
                4645                4650                4655    
Tyr Ile Lys Trp Asp Leu Leu Lys Tyr Asp Phe Thr Glu Glu Arg Leu 
            4660                4665                4670        
Lys Leu Phe Asp Arg Tyr Phe Lys Tyr Trp Asp Gln Thr Tyr His Pro 
        4675                4680                4685            
Asn Cys Val Asn Cys Leu Asp Asp Arg Cys Ile Leu His Cys Ala Asn 
    4690                4695                4700                
Phe Asn Val Leu Phe Ser Thr Val Phe Pro Pro Thr Ser Phe Gly Pro 
4705                4710                4715                4720
Leu Val Arg Lys Ile Phe Val Asp Gly Val Pro Phe Val Val Ser Thr 
                4725                4730                4735    
Gly Tyr His Phe Arg Glu Leu Gly Val Val His Asn Gln Asp Val Asn 
            4740                4745                4750        
Leu His Ser Ser Arg Leu Ser Phe Lys Glu Leu Leu Val Tyr Ala Ala 
        4755                4760                4765            
Asp Pro Ala Met His Ala Ala Ser Gly Asn Leu Leu Leu Asp Lys Arg 
    4770                4775                4780                
Thr Thr Cys Phe Ser Val Ala Ala Leu Thr Asn Asn Val Ala Phe Gln 
4785                4790                4795                4800
Thr Val Lys Pro Gly Asn Phe Asn Lys Asp Phe Tyr Asp Phe Ala Val 
                4805                4810                4815    
Ser Lys Gly Phe Phe Lys Glu Gly Ser Ser Val Glu Leu Lys His Phe 
            4820                4825                4830        
Phe Phe Ala Gln Asp Gly Asn Ala Ala Ile Ser Asp Tyr Asp Tyr Tyr 
        4835                4840                4845            
Arg Tyr Asn Leu Pro Thr Met Cys Asp Ile Arg Gln Leu Leu Phe Val 
    4850                4855                4860                
Val Glu Val Val Asp Lys Tyr Phe Asp Cys Tyr Asp Gly Gly Cys Ile 
4865                4870                4875                4880
Asn Ala Asn Gln Val Ile Val Asn Asn Leu Asp Lys Ser Ala Gly Phe 
                4885                4890                4895    
Pro Phe Asn Lys Trp Gly Lys Ala Arg Leu Tyr Tyr Asp Ser Met Ser 
            4900                4905                4910        
Tyr Glu Asp Gln Asp Ala Leu Phe Ala Tyr Thr Lys Arg Asn Val Ile 
        4915                4920                4925            
Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr Ala Ile Ser Ala Lys Asn 
    4930                4935                4940                
Arg Ala Arg Thr Val Ala Gly Val Ser Ile Cys Ser Thr Met Thr Asn 
4945                4950                4955                4960
Arg Gln Phe His Gln Lys Leu Leu Lys Ser Ile Ala Ala Thr Arg Gly 
                4965                4970                4975    
Ala Thr Val Val Ile Gly Thr Ser Lys Phe Tyr Gly Gly Trp His Asn 
            4980                4985                4990        
Met Leu Lys Thr Val Tyr Ser Asp Val Glu Asn Pro His Leu Met Gly 
        4995                5000                5005            
Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn Met Leu Arg Ile 
    5010                5015                5020                
Met Ala Ser Leu Val Leu Ala Arg Lys His Thr Thr Cys Cys Ser Leu 
5025                5030                5035                5040
Ser His Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala Gln Val Leu Ser 
                5045                5050                5055    
Glu Met Val Met Cys Gly Gly Ser Leu Tyr Val Lys Pro Gly Gly Thr 
            5060                5065                5070        
Ser Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser Val Phe Asn Ile 
        5075                5080                5085            
Cys Gln Ala Val Thr Ala Asn Val Asn Ala Leu Leu Ser Thr Asp Gly 
    5090                5095                5100                
Asn Lys Ile Ala Asp Lys Tyr Val Arg Asn Leu Gln His Arg Leu Tyr 
5105                5110                5115                5120
Glu Cys Leu Tyr Arg Asn Arg Asp Val Asp Thr Asp Phe Val Asn Glu 
                5125                5130                5135    
Phe Tyr Ala Tyr Leu Arg Lys His Phe Ser Met Met Ile Leu Ser Asp 
            5140                5145                5150        
Asp Ala Val Val Cys Phe Asn Ser Thr Tyr Ala Ser Gln Gly Leu Val 
        5155                5160                5165            
Ala Ser Ile Lys Asn Phe Lys Ser Val Leu Tyr Tyr Gln Asn Asn Val 
    5170                5175                5180                
Phe Met Ser Glu Ala Lys Cys Trp Thr Glu Thr Asp Leu Thr Lys Gly 
5185                5190                5195                5200
Pro His Glu Phe Cys Ser Gln His Thr Met Leu Val Lys Gln Gly Asp 
                5205                5210                5215    
Asp Tyr Val Tyr Leu Pro Tyr Pro Asp Pro Ser Arg Ile Leu Gly Ala 
            5220                5225                5230        
Gly Cys Phe Val Asp Asp Ile Val Lys Thr Asp Gly Thr Leu Met Ile 
        5235                5240                5245            
Glu Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro Leu Thr Lys His 
    5250                5255                5260                
Pro Asn Gln Glu Tyr Ala Asp Val Phe His Leu Tyr Leu Gln Tyr Ile 
5265                5270                5275                5280
Arg Lys Leu His Asp Glu Leu Thr Gly His Met Leu Asp Met Tyr Ser 
                5285                5290                5295    
Val Met Leu Thr Asn Asp Asn Thr Ser Arg Tyr Trp Glu Pro Glu Phe 
            5300                5305                5310        
Tyr Glu Ala Met Tyr Thr Pro His Thr Val Leu Gln Ala Val Gly Ala 
        5315                5320                5325            
Cys Val Leu Cys Asn Ser Gln Thr Ser Leu Arg Cys Gly Ala Cys Ile 
    5330                5335                5340                
Arg Arg Pro Phe Leu Cys Cys Lys Cys Cys Tyr Asp His Val Ile Ser 
5345                5350                5355                5360
Thr Ser His Lys Leu Val Leu Ser Val Asn Pro Tyr Val Cys Asn Ala 
                5365                5370                5375    
Pro Gly Cys Asp Val Thr Asp Val Thr Gln Leu Tyr Leu Gly Gly Met 
            5380                5385                5390        
Ser Tyr Tyr Cys Lys Ser His Lys Pro Pro Ile Ser Phe Pro Leu Cys 
        5395                5400                5405            
Ala Asn Gly Gln Val Phe Gly Leu Tyr Lys Asn Thr Cys Val Gly Ser 
    5410                5415                5420                
Asp Asn Val Thr Asp Phe Asn Ala Ile Ala Thr Cys Asp Trp Thr Asn 
5425                5430                5435                5440
Ala Gly Asp Tyr Ile Leu Ala Asn Thr Cys Thr Glu Arg Leu Lys Leu 
                5445                5450                5455    
Phe Ala Ala Glu Thr Leu Lys Ala Thr Glu Glu Thr Phe Lys Leu Ser 
            5460                5465                5470        
Tyr Gly Ile Ala Thr Val Arg Glu Val Leu Ser Asp Arg Glu Leu His 
        5475                5480                5485            
Leu Ser Trp Glu Val Gly Lys Pro Arg Pro Pro Leu Asn Arg Asn Tyr 
    5490                5495                5500                
Val Phe Thr Gly Tyr Arg Val Thr Lys Asn Ser Lys Val Gln Ile Gly 
5505                5510                5515                5520
Glu Tyr Thr Phe Glu Lys Gly Asp Tyr Gly Asp Ala Val Val Tyr Arg 
                5525                5530                5535    
Gly Thr Thr Thr Tyr Lys Leu Asn Val Gly Asp Tyr Phe Val Leu Thr 
            5540                5545                5550        
Ser His Thr Val Met Pro Leu Ser Ala Pro Thr Leu Val Pro Gln Glu 
        5555                5560                5565            
His Tyr Val Arg Ile Thr Gly Leu Tyr Pro Thr Leu Asn Ile Ser Asp 
    5570                5575                5580                
Glu Phe Ser Ser Asn Val Ala Asn Tyr Gln Lys Val Gly Met Gln Lys 
5585                5590                5595                5600
Tyr Ser Thr Leu Gln Gly Pro Pro Gly Thr Gly Lys Ser His Phe Ala 
                5605                5610                5615    
Ile Gly Leu Ala Leu Tyr Tyr Pro Ser Ala Arg Ile Val Tyr Thr Ala 
            5620                5625                5630        
Cys Ser His Ala Ala Val Asp Ala Leu Cys Glu Lys Ala Leu Lys Tyr 
        5635                5640                5645            
Leu Pro Ile Asp Lys Cys Ser Arg Ile Ile Pro Ala Arg Ala Arg Val 
    5650                5655                5660                
Glu Cys Phe Asp Lys Phe Lys Val Asn Ser Thr Leu Glu Gln Tyr Val 
5665                5670                5675                5680
Phe Cys Thr Val Asn Ala Leu Pro Glu Thr Thr Ala Asp Ile Val Val 
                5685                5690                5695    
Phe Asp Glu Ile Ser Met Ala Thr Asn Tyr Asp Leu Ser Val Val Asn 
            5700                5705                5710        
Ala Arg Leu Arg Ala Lys His Tyr Val Tyr Ile Gly Asp Pro Ala Gln 
        5715                5720                5725            
Leu Pro Ala Pro Arg Thr Leu Leu Thr Lys Gly Thr Leu Glu Pro Glu 
    5730                5735                5740                
Tyr Phe Asn Ser Val Cys Arg Leu Met Lys Thr Ile Gly Pro Asp Met 
5745                5750                5755                5760
Phe Leu Gly Thr Cys Arg Arg Cys Pro Ala Glu Ile Val Asp Thr Val 
                5765                5770                5775    
Ser Ala Leu Val Tyr Asp Asn Lys Leu Lys Ala His Lys Asp Lys Ser 
            5780                5785                5790        
Ala Gln Cys Phe Lys Met Phe Tyr Lys Gly Val Ile Thr His Asp Val 
        5795                5800                5805            
Ser Ser Ala Ile Asn Arg Pro Gln Ile Gly Val Val Arg Glu Phe Leu 
    5810                5815                5820                
Thr Arg Asn Pro Ala Trp Arg Lys Ala Val Phe Ile Ser Pro Tyr Asn 
5825                5830                5835                5840
Ser Gln Asn Ala Val Ala Ser Lys Ile Leu Gly Leu Pro Thr Gln Thr 
                5845                5850                5855    
Val Asp Ser Ser Gln Gly Ser Glu Tyr Asp Tyr Val Ile Phe Thr Gln 
            5860                5865                5870        
Thr Thr Glu Thr Ala His Ser Cys Asn Val Asn Arg Phe Asn Val Ala 
        5875                5880                5885            
Ile Thr Arg Ala Lys Val Gly Ile Leu Cys Ile Met Ser Asp Arg Asp 
    5890                5895                5900                
Leu Tyr Asp Lys Leu Gln Phe Thr Ser Leu Glu Ile Pro Arg Arg Asn 
5905                5910                5915                5920
Val Ala Thr Leu Gln Ala Glu Asn Val Thr Gly Leu Phe Lys Asp Cys 
                5925                5930                5935    
Ser Lys Val Ile Thr Gly Leu His Pro Thr Gln Ala Pro Thr His Leu 
            5940                5945                5950        
Ser Val Asp Thr Lys Phe Lys Thr Glu Gly Leu Cys Val Asp Ile Pro 
        5955                5960                5965            
Gly Ile Pro Lys Asp Met Thr Tyr Arg Arg Leu Ile Ser Met Met Gly 
    5970                5975                5980                
Phe Lys Met Asn Tyr Gln Val Asn Gly Tyr Pro Asn Met Phe Ile Thr 
5985                5990                5995                6000
Arg Glu Glu Ala Ile Arg His Val Arg Ala Trp Ile Gly Phe Asp Val 
                6005                6010                6015    
Glu Gly Cys His Ala Thr Arg Glu Ala Val Gly Thr Asn Leu Pro Leu 
            6020                6025                6030        
Gln Leu Gly Phe Ser Thr Gly Val Asn Leu Val Ala Val Pro Thr Gly 
        6035                6040                6045            
Tyr Val Asp Thr Pro Asn Asn Thr Asp Phe Ser Arg Val Ser Ala Lys 
    6050                6055                6060                
Pro Pro Pro Gly Asp Gln Phe Lys His Leu Ile Pro Leu Met Tyr Lys 
6065                6070                6075                6080
Gly Leu Pro Trp Asn Val Val Arg Ile Lys Ile Val Gln Met Leu Ser 
                6085                6090                6095    
Asp Thr Leu Lys Asn Leu Ser Asp Arg Val Val Phe Val Leu Trp Ala 
            6100                6105                6110        
His Gly Phe Glu Leu Thr Ser Met Lys Tyr Phe Val Lys Ile Gly Pro 
        6115                6120                6125            
Glu Arg Thr Cys Cys Leu Cys Asp Arg Arg Ala Thr Cys Phe Ser Thr 
    6130                6135                6140                
Ala Ser Asp Thr Tyr Ala Cys Trp His His Ser Ile Gly Phe Asp Tyr 
6145                6150                6155                6160
Val Tyr Asn Pro Phe Met Ile Asp Val Gln Gln Trp Gly Phe Thr Gly 
                6165                6170                6175    
Asn Leu Gln Ser Asn His Asp Leu Tyr Cys Gln Val His Gly Asn Ala 
            6180                6185                6190        
His Val Ala Ser Cys Asp Ala Ile Met Thr Arg Cys Leu Ala Val His 
        6195                6200                6205            
Glu Cys Phe Val Lys Arg Val Asp Trp Thr Ile Glu Tyr Pro Ile Ile 
    6210                6215                6220                
Gly Asp Glu Leu Lys Ile Asn Ala Ala Cys Arg Lys Val Gln His Met 
6225                6230                6235                6240
Val Val Lys Ala Ala Leu Leu Ala Asp Lys Phe Pro Val Leu His Asp 
                6245                6250                6255    
Ile Gly Asn Pro Lys Ala Ile Lys Cys Val Pro Gln Ala Asp Val Glu 
            6260                6265                6270        
Trp Lys Phe Tyr Asp Ala Gln Pro Cys Ser Asp Lys Ala Tyr Lys Ile 
        6275                6280                6285            
Glu Glu Leu Phe Tyr Ser Tyr Ala Thr His Ser Asp Lys Phe Thr Asp 
    6290                6295                6300                
Gly Val Cys Leu Phe Trp Asn Cys Asn Val Asp Arg Tyr Pro Ala Asn 
6305                6310                6315                6320
Ser Ile Val Cys Arg Phe Asp Thr Arg Val Leu Ser Asn Leu Asn Leu 
                6325                6330                6335    
Pro Gly Cys Asp Gly Gly Ser Leu Tyr Val Asn Lys His Ala Phe His 
            6340                6345                6350        
Thr Pro Ala Phe Asp Lys Ser Ala Phe Val Asn Leu Lys Gln Leu Pro 
        6355                6360                6365            
Phe Phe Tyr Tyr Ser Asp Ser Pro Cys Glu Ser His Gly Lys Gln Val 
    6370                6375                6380                
Val Ser Asp Ile Asp Tyr Val Pro Leu Lys Ser Ala Thr Cys Ile Thr 
6385                6390                6395                6400
Arg Cys Asn Leu Gly Gly Ala Val Cys Arg His His Ala Asn Glu Tyr 
                6405                6410                6415    
Arg Leu Tyr Leu Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser 
            6420                6425                6430        
Leu Trp Val Tyr Lys Gln Phe Asp Thr Tyr Asn Leu Trp Asn Thr Phe 
        6435                6440                6445            
Thr Arg Leu Gln Ser Leu Glu Asn Val Ala Phe Asn Val Val Asn Lys 
    6450                6455                6460                
Gly His Phe Asp Gly Gln Gln Gly Glu Val Pro Val Ser Ile Ile Asn 
6465                6470                6475                6480
Asn Thr Val Tyr Thr Lys Val Asp Gly Val Asp Val Glu Leu Phe Glu 
                6485                6490                6495    
Asn Lys Thr Thr Leu Pro Val Asn Val Ala Phe Glu Leu Trp Ala Lys 
            6500                6505                6510        
Arg Asn Ile Lys Pro Val Pro Glu Val Lys Ile Leu Asn Asn Leu Gly 
        6515                6520                6525            
Val Asp Ile Ala Ala Asn Thr Val Ile Trp Asp Tyr Lys Arg Asp Ala 
    6530                6535                6540                
Pro Ala His Ile Ser Thr Ile Gly Val Cys Ser Met Thr Asp Ile Ala 
6545                6550                6555                6560
Lys Lys Pro Thr Glu Thr Ile Cys Ala Pro Leu Thr Val Phe Phe Asp 
                6565                6570                6575    
Gly Arg Val Asp Gly Gln Val Asp Leu Phe Arg Asn Ala Arg Asn Gly 
            6580                6585                6590        
Val Leu Ile Thr Glu Gly Ser Val Lys Gly Leu Gln Pro Ser Val Gly 
        6595                6600                6605            
Pro Lys Gln Ala Ser Leu Asn Gly Val Thr Leu Ile Gly Glu Ala Val 
    6610                6615                6620                
Lys Thr Gln Phe Asn Tyr Tyr Lys Lys Val Asp Gly Val Val Gln Gln 
6625                6630                6635                6640
Leu Pro Glu Thr Tyr Phe Thr Gln Ser Arg Asn Leu Gln Glu Phe Lys 
                6645                6650                6655    
Pro Arg Ser Gln Met Glu Ile Asp Phe Leu Glu Leu Ala Met Asp Glu 
            6660                6665                6670        
Phe Ile Glu Arg Tyr Lys Leu Glu Gly Tyr Ala Phe Glu His Ile Val 
        6675                6680                6685            
Tyr Gly Asp Phe Ser His Ser Gln Leu Gly Gly Leu His Leu Leu Ile 
    6690                6695                6700                
Gly Leu Ala Lys Arg Phe Lys Glu Ser Pro Phe Glu Leu Glu Asp Phe 
6705                6710                6715                6720
Ile Pro Met Asp Ser Thr Val Lys Asn Tyr Phe Ile Thr Asp Ala Gln 
                6725                6730                6735    
Thr Gly Ser Ser Lys Cys Val Cys Ser Val Ile Asp Leu Leu Leu Asp 
            6740                6745                6750        
Asp Phe Val Glu Ile Ile Lys Ser Gln Asp Leu Ser Val Val Ser Lys 
        6755                6760                6765            
Val Val Lys Val Thr Ile Asp Tyr Thr Glu Ile Ser Phe Met Leu Trp 
    6770                6775                6780                
Cys Lys Asp Gly His Val Glu Thr Phe Tyr Pro Lys Leu Gln Ser Ser 
6785                6790                6795                6800
Gln Ala Trp Gln Pro Gly Val Ala Met Pro Asn Leu Tyr Lys Met Gln 
                6805                6810                6815    
Arg Met Leu Leu Glu Lys Cys Asp Leu Gln Asn Tyr Gly Asp Ser Ala 
            6820                6825                6830        
Thr Leu Pro Lys Gly Ile Met Met Asn Val Ala Lys Tyr Thr Gln Leu 
        6835                6840                6845            
Cys Gln Tyr Leu Asn Thr Leu Thr Leu Ala Val Pro Tyr Asn Met Arg 
    6850                6855                6860                
Val Ile His Phe Gly Ala Gly Ser Asp Lys Gly Val Ala Pro Gly Thr 
6865                6870                6875                6880
Ala Val Leu Arg Gln Trp Leu Pro Thr Gly Thr Leu Leu Val Asp Ser 
                6885                6890                6895    
Asp Leu Asn Asp Phe Val Ser Asp Ala Asp Ser Thr Leu Ile Gly Asp 
            6900                6905                6910        
Cys Ala Thr Val His Thr Ala Asn Lys Trp Asp Leu Ile Ile Ser Asp 
        6915                6920                6925            
Met Tyr Asp Pro Lys Thr Lys Asn Val Thr Lys Glu Asn Asp Ser Lys 
    6930                6935                6940                
Glu Gly Phe Phe Thr Tyr Ile Cys Gly Phe Ile Gln Gln Lys Leu Ala 
6945                6950                6955                6960
Leu Gly Gly Ser Val Ala Ile Lys Ile Thr Glu His Ser Trp Asn Ala 
                6965                6970                6975    
Asp Leu Tyr Lys Leu Met Gly His Phe Ala Trp Trp Thr Ala Phe Val 
            6980                6985                6990        
Thr Asn Val Asn Ala Ser Ser Ser Glu Ala Phe Leu Ile Gly Cys Asn 
        6995                7000                7005            
Tyr Leu Gly Lys Pro Arg Glu Gln Ile Asp Gly Tyr Val Met His Ala 
    7010                7015                7020                
Asn Tyr Ile Phe Trp Arg Asn Thr Asn Pro Ile Gln Leu Ser Ser Tyr 
7025                7030                7035                7040
Ser Leu Phe Asp Met Ser Lys Phe Pro Leu Lys Leu Arg Gly Thr Ala 
                7045                7050                7055    
Val Met Ser Leu Lys Glu Gly Gln Ile Asn Asp Met Ile Leu Ser Leu 
            7060                7065                7070        
Leu Ser Lys Gly Arg Leu Ile Ile Arg Glu Asn Asn Arg Val Val Ile 
        7075                7080                7085            
Ser Ser Asp Val Leu Val Asn Asn 
    7090                7095    

<210> 69
<211> 206
<212> PRT
<213> SARS coronavirus 2


<220> 
<223> AA 300 to 505 of YP_009724390.1 (S1.2)

<400> 69
Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
1               5                   10                  15      
Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            20                  25                  30          
Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        35                  40                  45              
Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    50                  55                  60                  
Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
65                  70                  75                  80  
Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                85                  90                  95      
Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            100                 105                 110         
Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        115                 120                 125             
Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    130                 135                 140                 
Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
145                 150                 155                 160 
Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                165                 170                 175     
Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            180                 185                 190         
Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
        195                 200                 205     

<210> 70
<211> 946
<212> PRT
<213> Artificial Sequence


<220> 
<223> HtW2_S1.2 Cap Protein Sequence

<400> 70
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Ala Ala Ala Lys Cys 
            580                 585                 590         
Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
        595                 600                 605             
Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
    610                 615                 620                 
Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
625                 630                 635                 640 
Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
                645                 650                 655     
Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
            660                 665                 670         
Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
        675                 680                 685             
Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
    690                 695                 700                 
Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
705                 710                 715                 720 
Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
                725                 730                 735     
Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
            740                 745                 750         
Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
        755                 760                 765             
Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
    770                 775                 780                 
Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Ala Ala Arg Gln 
785                 790                 795                 800 
Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val 
                805                 810                 815     
Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
            820                 825                 830         
Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe 
        835                 840                 845             
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
    850                 855                 860                 
Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe 
865                 870                 875                 880 
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
                885                 890                 895     
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
            900                 905                 910         
Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn 
        915                 920                 925             
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
    930                 935                 940                 
Asn Leu 
945     

<210> 71
<211> 59
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW2_S1.2_fw

<400> 71
tatctaccaa cctccagaga ggcaacgcgg cggcgaagtg caccctgaag agcttcacc      59


<210> 72
<211> 55
<212> DNA
<213> Artificial Sequence


<220> 
<223> pHtW2_S1.2_rv

<400> 72
ttgacatctg cggtagctgc ttggcgcgcc gcgtatccca ctccgttggt tggct          55


<210> 73
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> αGFP-scFv

<400> 73
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Thr Met Asn Trp Val Lys Gln Ser His Gly Gln Asn Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Leu Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Asn Ser Asp Phe Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
    130                 135                 140                 
Thr Gln Ser Pro Ala Ile Met Ser Pro Ser Leu Gly Glu Arg Val Thr 
145                 150                 155                 160 
Met Thr Cys Thr Ala Ser Ser Ser Val Gly Ser Ser Tyr Leu His Trp 
                165                 170                 175     
Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr 
            180                 185                 190         
Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             
Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala 
    210                 215                 220                 
Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Thr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 
Gly Gly Thr Lys Leu Glu Ile Lys 
                245             

<210> 74
<211> 988
<212> PRT
<213> Artificial Sequence


<220> 
<223> AAV2_αGFP-scFv

<400> 74
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Ala Ala Ala Glu Val 
            580                 585                 590         
Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser Ser Met 
        595                 600                 605             
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met 
    610                 615                 620                 
Asn Trp Val Lys Gln Ser His Gly Gln Asn Leu Glu Trp Ile Gly Leu 
625                 630                 635                 640 
Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys Gly 
                645                 650                 655     
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
            660                 665                 670         
Leu Leu Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg 
        675                 680                 685             
Gly Asn Ser Asp Phe Ser Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
    690                 695                 700                 
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln 
                725                 730                 735     
Ser Pro Ala Ile Met Ser Pro Ser Leu Gly Glu Arg Val Thr Met Thr 
            740                 745                 750         
Cys Thr Ala Ser Ser Ser Val Gly Ser Ser Tyr Leu His Trp Phe Gln 
        755                 760                 765             
Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
    770                 775                 780                 
Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
785                 790                 795                 800 
Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr 
                805                 810                 815     
Tyr Tyr Cys His Gln Tyr His Arg Thr Pro Tyr Thr Phe Gly Gly Gly 
            820                 825                 830         
Thr Lys Leu Glu Ile Lys Ala Ala Arg Gln Ala Ala Thr Ala Asp Val 
        835                 840                 845             
Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val 
    850                 855                 860                 
Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His 
865                 870                 875                 880 
Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro 
                885                 890                 895     
Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr 
            900                 905                 910         
Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr 
        915                 920                 925             
Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser 
    930                 935                 940                 
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser 
945                 950                 955                 960 
Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro 
                965                 970                 975     
Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            980                 985             

