               SEQUENCE LISTING

<110> Basilea Pharmaceutica International AG

<120> Use of c-Myc as a biomarker of drug response

<130> P1137EP00

<160> 4

<170> BiSSAP 1.3.6

<210> 1
<211> 268
<212> PRT
<213> Homo sapiens


<220> 
<223> EB1 protein sequence

<400> 1
Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser 
1               5                   10                  15      
Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu 
            20                  25                  30          
Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met 
        35                  40                  45              
Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln 
    50                  55                  60                  
Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala 
65                  70                  75                  80  
Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu 
                85                  90                  95      
Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys 
            100                 105                 110         
Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala 
        115                 120                 125             
Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro 
    130                 135                 140                 
Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro 
145                 150                 155                 160 
Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Ala Pro Lys Ala Gly 
                165                 170                 175     
Pro Gly Val Val Arg Lys Asn Pro Gly Val Gly Asn Gly Asp Asp Glu 
            180                 185                 190         
Ala Ala Glu Leu Met Gln Gln Val Asn Val Leu Lys Leu Thr Val Glu 
        195                 200                 205             
Asp Leu Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu Arg Asn Ile 
    210                 215                 220                 
Glu Leu Ile Cys Gln Glu Asn Glu Gly Glu Asn Asp Pro Val Leu Gln 
225                 230                 235                 240 
Arg Ile Val Asp Ile Leu Tyr Ala Thr Asp Glu Gly Phe Val Ile Pro 
                245                 250                 255     
Asp Glu Gly Gly Pro Gln Glu Glu Gln Glu Glu Tyr 
            260                 265             

<210> 2
<211> 2540
<212> DNA
<213> Homo sapiens


<220> 
<223> EB1 nucleic acid sequence

<400> 2
acgagacgaa gacggaaccg gagccggttg cgggcagtgg acgcggttct gccgagagcc      60

gaagatggca gtgaacgtat actcaacgtc agtgaccagt gataacctaa gtcgacatga     120

catgctggcc tggatcaatg agtctctgca gttgaatctg acaaagatcg aacagttgtg     180

ctcaggggct gcgtattgtc agtttatgga catgctgttc cctggctcca ttgccttgaa     240

gaaagtgaaa ttccaagcta agctagaaca cgagtacatc cagaacttca aaatactaca     300

agcaggtttt aagagaatgg gtgttgacaa aataattcct gtggacaaat tagtaaaagg     360

aaagtttcag gacaattttg aattcgttca gtggttcaag aagtttttcg atgcaaacta     420

tgatggaaaa gactatgacc ctgtggctgc cagacaaggt caagaaactg cagtggctcc     480

ttcccttgtt gctccagctc tgaataaacc gaagaaacct ctcacttcta gcagtgcagc     540

tccccagagg cccatctcaa cacagagaac cgctgcggct cctaaggctg gccctggtgt     600

ggtgcgaaag aaccctggtg tgggcaacgg agacgacgag gcagctgagt tgatgcagca     660

ggtcaacgta ttgaaactta ctgttgaaga cttggagaaa gagagggatt tctacttcgg     720

aaagctacgg aacattgaat tgatttgcca ggagaacgag ggggaaaacg accctgtatt     780

gcagaggatt gtagacattc tgtatgccac agatgaaggc tttgtgatac ctgatgaagg     840

gggcccacag gaggagcaag aagagtatta acagcctgga ccagcagagc aacatcggaa     900

ttcttcactc caaatcatgt gcttaactgt aaaatactcc cttttgttat ccttagagga     960

ctcactggtt tcttttcata agcaaaaagt acctcttctt aaagtgcact ttgcagacgt    1020

ttcactcctt ttccaataag tttgagttag gagcttttac cttgtagcag agcagtatta    1080

acatctagtt ggttcacctg gaaaacagag aggctgaccg tggggctcac catgcggatg    1140

cgggtcacac tgaatgctgg agagatgtat gtaatatgct gaggtggcga cctcagtgga    1200

gaaatgtaaa gactgaattg aattttaagc taatgtgaaa tcagagaatg ttgtaataag    1260

taaatgcctt aagagtattt aaaatatgct tccacatttc aaaatataaa atgtaacatg    1320

acaagagatt ttgcgtttga cattgtgtct gggaaggaag ggccagacct tggaaccttt    1380

ggaacctgct gtcaacaggt cttacagggc tgcttgaacc ctcataggcc taggctttgg    1440

tctaaaagga acatttaaaa agttgccctg taaagttatt tggtgtcatt gaccaattgc    1500

atcccagcta aaaagcaaga ggcatcgttg cctggataat agaggatgtg tttcagccct    1560

gagatgttac agttgaagag cttggtttca ttgagcattt ctctattttt ccagttatcc    1620

cgaaatttct atgtattatt ttttggggaa gtgaggtgtg cccagttttt taatctaaca    1680

actacttttg gggacttgcc cacatctctg ggatttgaat ggggattgta tcccatttta    1740

ctgtctttta ggtttacatt taccacgttt ctcttctctg ctccccttgc ccactgggac    1800

tcctctttgg ctccttgaag tttgctgctt agagttggaa gtgcagcagg caggtgatca    1860

tgctgcaagt tctttctgga cctctggcaa agggagtggt cagtgaaggc catcgttacc    1920

ttgggatctg ccaggctggg gtgttttcgg tatctgctgt tcacagctct ccactgtaat    1980

ccgaatactt tgccagtgca ctaatctctt tggagataaa attcattagt gtgttactaa    2040

atgttaattt tcttttgcgg aaaatacagt accgtgtctg aattaattat taatatttaa    2100

aatacttcat tccttaactc tccctcattt gctttgccca cagcctattc agttcctttg    2160

tttggcagga ttctgcaaaa tgtgtctcac ccactactga gattgttcag cccctgatgt    2220

atttgtattg atttgtttct ggtggtagct tgtcctgaaa tgtgtgtaga aagcaagtat    2280

tttatgataa aaatgttgtg tagtgcatgc tctgtgtgga attcagagga aaacccagat    2340

tcagtgatta acaatgccaa aaaatgcaag taactagcca ttgttcaaat gacagtggtg    2400

ctatttctct tttgtggcct tttagacttt tgttgcccta aaattccatt ttattgggaa    2460

cccattttcc acctggtctt tcttgacagg gtttttttct actttaaaca gtttctaaat    2520

aaaattctgt atttcaaaaa                                                2540


<210> 3
<211> 453
<212> PRT
<213> Homo sapiens


<220> 
<223> c-Myc protein sequence

<400> 3
Met Asp Phe Phe Arg Val Val Glu Asn Gln Pro Pro Ala Thr Met Pro 
1               5                   10                  15      
Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp Ser 
            20                  25                  30          
Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln Gln 
        35                  40                  45              
Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile Trp 
    50                  55                  60                  
Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg Arg 
65                  70                  75                  80  
Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser Leu 
                85                  90                  95      
Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp Gln 
            100                 105                 110         
Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln Ser 
        115                 120                 125             
Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile Ile 
    130                 135                 140                 
Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val Ser 
145                 150                 155                 160 
Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser Pro 
                165                 170                 175     
Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr Leu 
            180                 185                 190         
Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val Val 
        195                 200                 205             
Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala Ser 
    210                 215                 220                 
Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser Ser 
225                 230                 235                 240 
Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His Glu 
                245                 250                 255     
Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu Asp 
            260                 265                 270         
Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro Gly 
        275                 280                 285             
Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys Pro 
    290                 295                 300                 
Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His Gln 
305                 310                 315                 320 
His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala Ala 
                325                 330                 335     
Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser Asn 
            340                 345                 350         
Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn Val 
        355                 360                 365             
Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu Leu 
    370                 375                 380                 
Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu Asn 
385                 390                 395                 400 
Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr 
                405                 410                 415     
Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            420                 425                 430         
Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln Leu 
        435                 440                 445             
Arg Asn Ser Cys Ala 
    450             

<210> 4
<211> 4515
<212> DNA
<213> Homo sapiens


<220> 
<223> c-Myc nucleic acid sequence

<400> 4
ggagtttatt cataacgcgc tctccaagta tacgtggcaa tgcgttgctg ggttatttta       60

atcattctag gcatcgtttt cctccttatg cctctatcat tcctccctat ctacactaac      120

atcccacgct ctgaacgcgc gcccattaat acccttcttt cctccactct ccctgggact      180

cttgatcaaa gcgcggccct ttccccagcc ttagcgaggc gccctgcagc ctggtacgcg      240

cgtggcgtgg cggtgggcgc gcagtgcgtt ctcggtgtgg agggcagctg ttccgcctgc      300

gatgatttat actcacagga caaggatgcg gtttgtcaaa cagtactgct acggaggagc      360

agcagagaaa gggagagggt ttgagaggga gcaaaagaaa atggtaggcg cgcgtagtta      420

attcatgcgg ctctcttact ctgtttacat cctagagcta gagtgctcgg ctgcccggct      480

gagtctcctc cccaccttcc ccaccctccc caccctcccc ataagcgccc ctcccgggtt      540

cccaaagcag agggcgtggg ggaaaagaaa aaagatcctc tctcgctaat ctccgcccac      600

cggcccttta taatgcgagg gtctggacgg ctgaggaccc ccgagctgtg ctgctcgcgg      660

ccgccaccgc cgggccccgg ccgtccctgg ctcccctcct gcctcgagaa gggcagggct      720

tctcagaggc ttggcgggaa aaagaacgga gggagggatc gcgctgagta taaaagccgg      780

ttttcggggc tttatctaac tcgctgtagt aattccagcg agaggcagag ggagcgagcg      840

ggcggccggc tagggtggaa gagccgggcg agcagagctg cgctgcgggc gtcctgggaa      900

gggagatccg gagcgaatag ggggcttcgc ctctggccca gccctcccgc tgatccccca      960

gccagcggtc cgcaaccctt gccgcatcca cgaaactttg cccatagcag cgggcgggca     1020

ctttgcactg gaacttacaa cacccgagca aggacgcgac tctcccgacg cggggaggct     1080

attctgccca tttggggaca cttccccgcc gctgccagga cccgcttctc tgaaaggctc     1140

tccttgcagc tgcttagacg ctggattttt ttcgggtagt ggaaaaccag cctcccgcga     1200

cgatgcccct caacgttagc ttcaccaaca ggaactatga cctcgactac gactcggtgc     1260

agccgtattt ctactgcgac gaggaggaga acttctacca gcagcagcag cagagcgagc     1320

tgcagccccc ggcgcccagc gaggatatct ggaagaaatt cgagctgctg cccaccccgc     1380

ccctgtcccc tagccgccgc tccgggctct gctcgccctc ctacgttgcg gtcacaccct     1440

tctcccttcg gggagacaac gacggcggtg gcgggagctt ctccacggcc gaccagctgg     1500

agatggtgac cgagctgctg ggaggagaca tggtgaacca gagtttcatc tgcgacccgg     1560

acgacgagac cttcatcaaa aacatcatca tccaggactg tatgtggagc ggcttctcgg     1620

ccgccgccaa gctcgtctca gagaagctgg cctcctacca ggctgcgcgc aaagacagcg     1680

gcagcccgaa ccccgcccgc ggccacagcg tctgctccac ctccagcttg tacctgcagg     1740

atctgagcgc cgccgcctca gagtgcatcg acccctcggt ggtcttcccc taccctctca     1800

acgacagcag ctcgcccaag tcctgcgcct cgcaagactc cagcgccttc tctccgtcct     1860

cggattctct gctctcctcg acggagtcct ccccgcaggg cagccccgag cccctggtgc     1920

tccatgagga gacaccgccc accaccagca gcgactctga ggaggaacaa gaagatgagg     1980

aagaaatcga tgttgtttct gtggaaaaga ggcaggctcc tggcaaaagg tcagagtctg     2040

gatcaccttc tgctggaggc cacagcaaac ctcctcacag cccactggtc ctcaagaggt     2100

gccacgtctc cacacatcag cacaactacg cagcgcctcc ctccactcgg aaggactatc     2160

ctgctgccaa gagggtcaag ttggacagtg tcagagtcct gagacagatc agcaacaacc     2220

gaaaatgcac cagccccagg tcctcggaca ccgaggagaa tgtcaagagg cgaacacaca     2280

acgtcttgga gcgccagagg aggaacgagc taaaacggag cttttttgcc ctgcgtgacc     2340

agatcccgga gttggaaaac aatgaaaagg cccccaaggt agttatcctt aaaaaagcca     2400

cagcatacat cctgtccgtc caagcagagg agcaaaagct catttctgaa gaggacttgt     2460

tgcggaaacg acgagaacag ttgaaacaca aacttgaaca gctacggaac tcttgtgcgt     2520

aaggaaaagt aaggaaaacg attccttcta acagaaatgt cctgagcaat cacctatgaa     2580

cttgtttcaa atgcatgatc aaatgcaacc tcacaacctt ggctgagtct tgagactgaa     2640

agatttagcc ataatgtaaa ctgcctcaaa ttggactttg ggcataaaag aactttttta     2700

tgcttaccat cttttttttt tctttaacag atttgtattt aagaattgtt tttaaaaaat     2760

tttaagattt acacaatgtt tctctgtaaa tattgccatt aaatgtaaat aactttaata     2820

aaacgtttat agcagttaca cagaatttca atcctagtat atagtaccta gtattatagg     2880

tactataaac cctaattttt tttatttaag tacattttgc tttttaaagt tgattttttt     2940

ctattgtttt tagaaaaaat aaaataactg gcaaatatat cattgagcca aatcttaagt     3000

tgtgaatgtt ttgtttcgtt tcttccccct cccaaccacc accatccctg tttgttttca     3060

tcaattgccc cttcagaggg tggtcttaag aaaggcaaga gttttcctct gttgaaatgg     3120

gtctgggggc cttaaggtct ttaagttctt ggaggttcta agatgcttcc tggagactat     3180

gataacagcc agagttgaca gttagaagga atggcagaag gcaggtgaga aggtgagagg     3240

taggcaaagg agatacaaga ggtcaaaggt agcagttaag tacacaaaga ggcataagga     3300

ctggggagtt gggaggaagg tgaggaagaa actcctgtta ctttagttaa ccagtgccag     3360

tcccctgctc actccaaacc caggaattct gcccagttga tggggacacg gtgggaacca     3420

gcttctgctg ccttcacaac caggcgccag tcctgtccat gggttatctc gcaaacccca     3480

gaggatctct gggaggaatg ctactattaa ccctatttca caaacaagga aatagaagag     3540

ctcaaagagg ttatgtaact tatctgtagc cacgcagata atacaaagca gcaatctgga     3600

cccattctgt tcaaaacact taacccttcg ctatcatgcc ttggttcatc tgggtctaat     3660

gtgctgagat caagaaggtt taggacctaa tggacagact caagtcataa caatgctaag     3720

ctctatttgt gtcccaagca ctcctaagca ttttatccct aactctacat caaccccatg     3780

aaggagatac tgttgatttc cccatattag aagtagagag ggaagctgag gcacacaaag     3840

actcatccac atgcccaaga ttcactgata gggaaaagtg gaagcgagat ttgaacccag     3900

gctgtttact cctaacctgt ccaagccacc tctcagacga cggtaggaat cagctggctg     3960

cttgtgagta caggagttac agtccagtgg gttatgtttt ttaagtctca acatctaagc     4020

ctggtcaggc atcagttccc ctttttttgt gatttatttt gtttttattt tgttgttcat     4080

tgtttaattt ttccttttac aatgagaagg tcaccatctt gactcctacc ttagccattt     4140

gttgaatcag actcatgacg gctcctggga agaagccagt tcagatcata aaataaaaca     4200

tatttattct ttgtcatggg agtcattatt ttagaaacta caaactctcc ttgcttccat     4260

ccttttttac atactcatga cacatgctca tcctgagtcc ttgaaaaggt atttttgaac     4320

atgtgtatta attataagcc tctgaaaacc tatggcccaa accagaaatg atgttgatta     4380

tataggtaaa tgaaggatgc tattgctgtt ctaattacct cattgtctca gtctcaaagt     4440

aggtcttcag ctccctgtac tttgggattt taatctacca ccacccataa atcaataaat     4500

aattactttc tttga                                                      4515


