﻿                         SEQUENCE LISTING

<110>  SHANDONG BOAN BIOTECHNOLOGY CO., LTD.
       Boan Boston LLC
 
<120>  Downregulation of Membrane-Bound Proteins by Receptor TAC 
       Technology

<130>  BA13

<150>  US 63/077,658
<151>  2020-09-13

<150>  US 63/144,945
<151>  2021-02-02

<150>  US 63/173,476
<151>  2021-04-11

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 CAR scFv

<400>  1

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  2
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP34 scFv

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
145                 150                 155                 160 


Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
                165                 170                 175     


Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
            180                 185                 190         


Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
    210                 215                 220                 


Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser 
225                 230                 235                 240 


Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 


<210>  3
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg 
    


<210>  4
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UCHT1 scFv

<400>  4

Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210>  5
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UCHT1.Y177T scFv

<400>  5

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  6
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2K scFv

<400>  6

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


<210>  7
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F6A scFv

<400>  7

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr Ala Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                165                 170                 175     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ser 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    210                 215                 220                 


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  8
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMA031 scFv(i.e. BMA031.wt scFv)

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys 
    


<210>  9
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMA031.H6L12 scFv

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala 
145                 150                 155                 160 


Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  10
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  αCD5.14 scFv

<400>  10

Ile Asp Ala Met Gly Asn Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
1               5                   10                  15      


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
            20                  25                  30          


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
        35                  40                  45              


Gly Leu Arg Trp Met Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr 
    50                  55                  60                  


Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
65                  70                  75                  80  


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr 
                85                  90                  95      


Ala Thr Tyr Phe Cys Thr Arg Arg Gly Tyr Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe His His 
                165                 170                 175     


Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu 
            180                 185                 190         


Val Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr Glu Asp Met Gly Ile Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Asp Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Met Lys Gly Ser Gly Asp Pro Ala 
                245                 250     


<210>  11
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  αCD7.TH69 scFv

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Ala Ala Tyr Lys Asp Ile Gln Met Thr Gln Thr Thr 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  12
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  αPD-L1 scFv

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Thr Tyr Ala Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ile Trp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
    130                 135                 140                 


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val 
145                 150                 155                 160 


Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  13
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  αCD47 ScFv

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Ile Val Tyr Ser Asn Gly Asn Thr Tyr Leu Gly Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  14
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 hinge

<400>  14

Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr 
1               5                   10                  15      


Trp Ser Thr Pro Val Gln Pro 
            20              


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 Transmembrane domain

<400>  15

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  16
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8α hinge

<400>  16

Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45      


<210>  17
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8α transmembrane domain(used in LS008*)

<400>  17

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8α transmembrane domain

<400>  18

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Peptide (CD8α)

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Peptide(IGHV3-23)

<400>  20

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  21
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIP

<400>  21

Met Lys Gly Lys Glu Glu Lys Glu Gly Gly Ala Arg Leu Gly Ala Gly 
1               5                   10                  15      


Gly Gly Ser Pro Glu Lys Ser Pro Ser Ala Gln Glu Leu Lys Glu Gln 
            20                  25                  30          


Gly Asn Arg Leu Phe Val Gly Arg Lys Tyr Pro Glu Ala Ala Ala Cys 
        35                  40                  45              


Tyr Gly Arg Ala Ile Thr Arg Asn Pro Leu Val Ala Val Tyr Tyr Thr 
    50                  55                  60                  


Asn Arg Ala Leu Cys Tyr Leu Lys Met Gln Gln His Glu Gln Ala Leu 
65                  70                  75                  80  


Ala Asp Cys Arg Arg Ala Leu Glu Leu Asp Gly Gln Ser Val Lys Ala 
                85                  90                  95      


His Phe Phe Leu Gly Gln Cys Gln Leu Glu Met Glu Ser Tyr Asp Glu 
            100                 105                 110         


Ala Ile Ala Asn Leu Gln Arg Ala Tyr Ser Leu Ala Lys Glu Gln Arg 
        115                 120                 125             


Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys 
    130                 135                 140                 


Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu 
145                 150                 155                 160 


Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu 
                165                 170                 175     


Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His 
            180                 185                 190         


Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met 
        195                 200                 205             


Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys 
    210                 215                 220                 


Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met 
225                 230                 235                 240 


Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp 
                245                 250                 255     


Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg 
            260                 265                 270         


Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu 
        275                 280                 285             


Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
    290                 295                 300             


<210>  22
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIP.dTPR(i.e.h CHIP.dTPR or hCHIP. ΔTPR)

<400>  22

Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
1               5                   10                  15      


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
            20                  25                  30          


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
        35                  40                  45              


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
    50                  55                  60                  


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
65                  70                  75                  80  


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
                85                  90                  95      


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
            100                 105                 110         


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
        115                 120                 125             


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
    130                 135                 140                 


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
145                 150                 155                 160 


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
                165                 170                 175     


<210>  23
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FBW7.2-293(i.e. FBW7)

<400>  23

Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr Cys 
1               5                   10                  15      


Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr Cys 
            20                  25                  30          


Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys Gly 
        35                  40                  45              


Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr Glu 
    50                  55                  60                  


Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr Leu 
65                  70                  75                  80  


Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser Glu 
                85                  90                  95      


Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr 
            100                 105                 110         


Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe 
        115                 120                 125             


Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile 
    130                 135                 140                 


Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe 
145                 150                 155                 160 


Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile 
                165                 170                 175     


Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile Glu 
            180                 185                 190         


Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala 
        195                 200                 205             


Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala 
    210                 215                 220                 


Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp 
225                 230                 235                 240 


Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys 
                245                 250                 255     


Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser 
            260                 265                 270         


Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu 
        275                 280                 285             


Leu Lys Ser Pro 
    290         


<210>  24
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHL.152-213(i.e.VHL)

<400>  24

Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys Leu Gln Val Val Arg 
1               5                   10                  15      


Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu Asp Ile Val Arg Ser 
            20                  25                  30          


Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val Gln Lys Asp Leu Glu 
        35                  40                  45              


Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg Met Gly Asp 
    50                  55                  60          


<210>  25
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPOP.167-374(i.e.SPOP)

<400>  25

Ser Val Asn Ile Ser Gly Gln Asn Thr Met Asn Met Val Lys Val Pro 
1               5                   10                  15      


Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly Leu Trp Glu Asn Ser Arg 
            20                  25                  30          


Phe Thr Asp Cys Cys Leu Cys Val Ala Gly Gln Glu Phe Gln Ala His 
        35                  40                  45              


Lys Ala Ile Leu Ala Ala Arg Ser Pro Val Phe Ser Ala Met Phe Glu 
    50                  55                  60                  


His Glu Met Glu Glu Ser Lys Lys Asn Arg Val Glu Ile Asn Asp Val 
65                  70                  75                  80  


Glu Pro Glu Val Phe Lys Glu Met Met Cys Phe Ile Tyr Thr Gly Lys 
                85                  90                  95      


Ala Pro Asn Leu Asp Lys Met Ala Asp Asp Leu Leu Ala Ala Ala Asp 
            100                 105                 110         


Lys Tyr Ala Leu Glu Arg Leu Lys Val Met Cys Glu Asp Ala Leu Cys 
        115                 120                 125             


Ser Asn Leu Ser Val Glu Asn Ala Ala Glu Ile Leu Ile Leu Ala Asp 
    130                 135                 140                 


Leu His Ser Ala Asp Gln Leu Lys Thr Gln Ala Val Asp Phe Ile Asn 
145                 150                 155                 160 


Tyr His Ala Ser Asp Val Leu Glu Thr Ser Gly Trp Lys Ser Met Val 
                165                 170                 175     


Val Ser His Pro His Leu Val Ala Glu Ala Tyr Arg Ser Leu Ala Ser 
            180                 185                 190         


Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg Lys Arg Leu Lys Gln Ser 
        195                 200                 205             


<210>  26
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SOCS2.143-198(i.e. SOCS2)

<400>  26

Pro Arg Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr 
1               5                   10                  15      


Ser Ala Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys 
            20                  25                  30          


Thr Gly Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr 
        35                  40                  45              


Leu Glu Glu Tyr Lys Phe Gln Val 
    50                  55      


<210>  27
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LS008*( αCD19 CAR)

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  28
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG024*

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Gln Ile Thr Arg Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 


<210>  29
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG085*

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile 
                245                 250                 255     


Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu 
            260                 265                 270         


Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg 
        275                 280                 285             


Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn 
    290                 295                 300                 


His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys 
305                 310                 315                 320 


Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe 
                325                 330                 335     


Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu 
            340                 345                 350         


Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro 
        355                 360                 365             


Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg 
    370                 375                 380                 


Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln 
385                 390                 395                 400 


Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser 
                405                 410                 415     


Glu Asn Gly Trp Val Glu Asp Tyr 
            420                 


<210>  30
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG089*

<400>  30

Cys Val Pro Arg Ser Gly Leu Ile Leu Ser Cys Ile Cys Leu Tyr Cys 
1               5                   10                  15      


Gly Val Leu Leu Pro Val Leu Leu Pro Asn Leu Pro Phe Leu Thr Cys 
            20                  25                  30          


Leu Ser Met Ser Thr Leu Glu Ser Val Thr Tyr Leu Pro Glu Lys Gly 
        35                  40                  45              


Leu Tyr Cys Gln Arg Leu Pro Ser Ser Arg Thr His Gly Gly Thr Glu 
    50                  55                  60                  


Ser Leu Lys Gly Lys Asn Thr Glu Asn Met Gly Phe Tyr Gly Thr Leu 
65                  70                  75                  80  


Lys Met Ile Phe Tyr Lys Met Lys Arg Lys Leu Asp His Gly Ser Glu 
                85                  90                  95      


Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu Tyr 
            100                 105                 110         


Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr Phe 
        115                 120                 125             


Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg Ile 
    130                 135                 140                 


Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met Phe 
145                 150                 155                 160 


Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu Ile 
                165                 170                 175     


Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile Glu 
            180                 185                 190         


Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu Ala 
        195                 200                 205             


Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala Ala 
    210                 215                 220                 


Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu Trp 
225                 230                 235                 240 


Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile Lys 
                245                 250                 255     


Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys Ser 
            260                 265                 270         


Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly Glu 
        275                 280                 285             


Leu Lys Ser Pro Gly Ser Gly Ser Gly Ser Gly Glu Val Gln Leu Val 
    290                 295                 300                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
305                 310                 315                 320 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
                325                 330                 335     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
            340                 345                 350         


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
    370                 375                 380                 


Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
385                 390                 395                 400 


Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
                405                 410                 415     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
        435                 440                 445             


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
    450                 455                 460                 


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
465                 470                 475                 480 


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
                485                 490                 495     


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
            500                 505                 510         


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
        515                 520                 525             


Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe 
    530                 535                 540                 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
545                 550             


<210>  31
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG091*

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
145                 150                 155                 160 


Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
                165                 170                 175     


Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
            180                 185                 190         


Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
    210                 215                 220                 


Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser 
225                 230                 235                 240 


Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Thr Leu Pro Val Tyr Thr Leu Lys Glu Arg Cys 
            260                 265                 270         


Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg Arg Leu 
        275                 280                 285             


Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro Asn Val 
    290                 295                 300                 


Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His Gln Arg 
305                 310                 315                 320 


Met Gly Asp 
            


<210>  32
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG092*

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
145                 150                 155                 160 


Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser 
                165                 170                 175     


Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
            180                 185                 190         


Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
    210                 215                 220                 


Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser 
225                 230                 235                 240 


Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Ser Val Asn Ile Ser Gly Gln Asn Thr Met Asn 
            260                 265                 270         


Met Val Lys Val Pro Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly Leu 
        275                 280                 285             


Trp Glu Asn Ser Arg Phe Thr Asp Cys Cys Leu Cys Val Ala Gly Gln 
    290                 295                 300                 


Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg Ser Pro Val Phe 
305                 310                 315                 320 


Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg Val 
                325                 330                 335     


Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu Met Met Cys Phe 
            340                 345                 350         


Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met Ala Asp Asp Leu 
        355                 360                 365             


Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met Cys 
    370                 375                 380                 


Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Ala Ala Glu Ile 
385                 390                 395                 400 


Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu Lys Thr Gln Ala 
                405                 410                 415     


Val Asp Phe Ile Asn Tyr His Ala Ser Asp Val Leu Glu Thr Ser Gly 
            420                 425                 430         


Trp Lys Ser Met Val Val Ser His Pro His Leu Val Ala Glu Ala Tyr 
        435                 440                 445             


Arg Ser Leu Ala Ser Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg Lys 
    450                 455                 460                 


Arg Leu Lys Gln Ser 
465                 


<210>  33
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG112*

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Gln Ile Thr Arg Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn 
            260                 265                 270         


Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg 
        275                 280                 285             


Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His 
    290                 295                 300                 


Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu 
305                 310                 315                 320 


Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg 
                325                 330                 335     


Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp 
            340                 345                 350         


Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp 
        355                 360                 365             


Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu 
    370                 375                 380                 


Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu 
385                 390                 395                 400 


Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro 
                405                 410                 415     


Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile 
            420                 425                 430         


Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr 
        435                 440                 445             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    450                 455                 460                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
465                 470                 475                 480 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                485                 490                 495     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            500                 505                 510         


<210>  34
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG112*△SP

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile 
                245                 250                 255     


Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu 
            260                 265                 270         


Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg 
        275                 280                 285             


Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn 
    290                 295                 300                 


His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys 
305                 310                 315                 320 


Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe 
                325                 330                 335     


Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu 
            340                 345                 350         


Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro 
        355                 360                 365             


Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg 
    370                 375                 380                 


Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln 
385                 390                 395                 400 


Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser 
                405                 410                 415     


Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg 
            420                 425                 430         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        435                 440                 445             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    450                 455                 460                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
465                 470                 475                 480 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490     


<210>  35
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG113*

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Gln Ile Thr Arg Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Gly Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
            340                 345                 350         


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
        355                 360                 365             


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
    370                 375                 380                 


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
385                 390                 395                 400 


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
                405                 410                 415     


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
            420                 425                 430         


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
        435                 440                 445             


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
    450                 455                 460                 


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
465                 470                 475                 480 


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
                485                 490                 495     


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
            500                 505                 510         


<210>  36
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG113*△SP

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly 
305                 310                 315                 320 


Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn 
                325                 330                 335     


Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr 
            340                 345                 350         


Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys 
        355                 360                 365             


Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln 
    370                 375                 380                 


Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp 
385                 390                 395                 400 


Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro 
                405                 410                 415     


Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys 
            420                 425                 430         


Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His 
        435                 440                 445             


Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr 
    450                 455                 460                 


Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala 
465                 470                 475                 480 


Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
                485                 490     


<210>  37
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG123*

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys 
            180                 185                 190         


Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp 
                245                 250                 255     


Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe Ser Gly 
            260                 265                 270         


Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser 
        275                 280                 285             


Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg 
    290                 295                 300                 


Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg Leu Ile 
305                 310                 315                 320 


Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn His Glu 
                325                 330                 335     


Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys Ile Glu 
            340                 345                 350         


Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe Ser Gln 
        355                 360                 365             


Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly 
    370                 375                 380                 


Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro Ser Gly 
385                 390                 395                 400 


Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg Val Gly 
                405                 410                 415     


His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile 
            420                 425                 430         


Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser Glu Asn 
        435                 440                 445             


Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    450                 455                 460                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
465                 470                 475                 480 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                485                 490                 495     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            500                 505                 510         


Val Leu Leu Leu Ser Leu Val Ile Thr 
        515                 520     


<210>  38
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG123*△SP

<400>  38

Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser Gly Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala 
            260                 265                 270         


Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu 
        275                 280                 285             


Ser Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu 
    290                 295                 300                 


Arg Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Ser His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys 
                325                 330                 335     


Tyr Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg 
            340                 345                 350         


Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu 
        355                 360                 365             


Leu Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg 
    370                 375                 380                 


Lys Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val 
385                 390                 395                 400 


Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met 
                405                 410                 415     


Lys Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp 
            420                 425                 430         


Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        435                 440                 445             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    450                 455                 460                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
465                 470                 475                 480 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                485                 490                 495     


Leu Val Ile Thr 
            500 


<210>  39
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG124*

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
                165                 170                 175     


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Leu Ile Asn Pro Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser 
            260                 265                 270         


Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala 
        275                 280                 285             


Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu 
    290                 295                 300                 


Ser Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu 
305                 310                 315                 320 


Arg Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp 
                325                 330                 335     


Ser His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys 
            340                 345                 350         


Tyr Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg 
        355                 360                 365             


Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu 
    370                 375                 380                 


Leu Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg 
385                 390                 395                 400 


Lys Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val 
                405                 410                 415     


Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met 
            420                 425                 430         


Lys Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp 
        435                 440                 445             


Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    450                 455                 460                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
465                 470                 475                 480 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                485                 490                 495     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            500                 505                 510         


Leu Val Ile Thr 
        515     


<210>  40
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG124*△SP

<400>  40

Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe 
                245                 250                 255     


Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp 
            260                 265                 270         


Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser 
        275                 280                 285             


Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu 
    290                 295                 300                 


Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala 
305                 310                 315                 320 


Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met 
                325                 330                 335     


Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile 
            340                 345                 350         


Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro 
        355                 360                 365             


Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu 
    370                 375                 380                 


His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu 
385                 390                 395                 400 


Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp 
                405                 410                 415     


Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr 
            420                 425                 430         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        435                 440                 445             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    450                 455                 460                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
465                 470                 475                 480 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 495 


<210>  41
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG125*

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
        35                  40                  45              


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
    50                  55                  60                  


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
    130                 135                 140                 


Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
                245                 250                 255     


Leu Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe 
            260                 265                 270         


Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp 
        275                 280                 285             


Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser 
    290                 295                 300                 


Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu 
305                 310                 315                 320 


Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala 
                325                 330                 335     


Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met 
            340                 345                 350         


Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile 
        355                 360                 365             


Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro 
    370                 375                 380                 


Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu 
385                 390                 395                 400 


His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu 
                405                 410                 415     


Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp 
            420                 425                 430         


Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr 
        435                 440                 445             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    450                 455                 460                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
465                 470                 475                 480 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                485                 490                 495     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            500                 505                 510     


<210>  42
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG125*△SP

<400>  42

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                165                 170                 175     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            180                 185                 190         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    210                 215                 220                 


Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro 
                245                 250                 255     


Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu 
            260                 265                 270         


Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg Leu 
        275                 280                 285             


Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn His 
    290                 295                 300                 


Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys Ile 
305                 310                 315                 320 


Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe Ser 
                325                 330                 335     


Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys 
            340                 345                 350         


Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro Ser 
        355                 360                 365             


Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg Val 
    370                 375                 380                 


Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu 
385                 390                 395                 400 


Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser Glu 
                405                 410                 415     


Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490 


<210>  43
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG126*

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
            20                  25                  30          


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
        35                  40                  45              


Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
65                  70                  75                  80  


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
                85                  90                  95      


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala 
            100                 105                 110         


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile 
                165                 170                 175     


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser 
            260                 265                 270         


Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala 
        275                 280                 285             


Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg 
    290                 295                 300                 


Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala 
305                 310                 315                 320 


Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly 
                325                 330                 335     


Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala 
            340                 345                 350         


Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val 
        355                 360                 365             


Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys 
    370                 375                 380                 


Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile 
385                 390                 395                 400 


Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg Val Gly His 
                405                 410                 415     


Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro 
            420                 425                 430         


Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly 
        435                 440                 445             


Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    450                 455                 460                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
465                 470                 475                 480 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                485                 490                 495     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            500                 505                 510         


Leu Leu Leu Ser Leu Val Ile Thr 
        515                 520 


<210>  44
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG126*△SP

<400>  44

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr Ala Met Asn Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                165                 170                 175     


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ser 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
    210                 215                 220                 


His Gly Asn Phe Gly Asn Ser Tyr Val Ser Phe Phe Ala Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gly 
                245                 250                 255     


Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
            260                 265                 270         


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
        275                 280                 285             


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
    290                 295                 300                 


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
305                 310                 315                 320 


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
                325                 330                 335     


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
            340                 345                 350         


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
        355                 360                 365             


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
    370                 375                 380                 


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
385                 390                 395                 400 


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
                405                 410                 415     


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
            420                 425                 430         


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        435                 440                 445             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    450                 455                 460                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
465                 470                 475                 480 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                485                 490                 495     


Val Ile Thr 
            


<210>  45
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG119*

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Lys Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe 
        115                 120                 125             


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
                165                 170                 175     


Met Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly 
                245                 250                 255     


Thr Lys Leu Glu Leu Lys Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn 
            260                 265                 270         


Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg 
        275                 280                 285             


Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His 
    290                 295                 300                 


Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu 
305                 310                 315                 320 


Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg 
                325                 330                 335     


Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp 
            340                 345                 350         


Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp 
        355                 360                 365             


Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu 
    370                 375                 380                 


Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu 
385                 390                 395                 400 


Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro 
                405                 410                 415     


Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile 
            420                 425                 430         


Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr 
        435                 440                 445             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    450                 455                 460                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
465                 470                 475                 480 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                485                 490                 495     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            500                 505                 510         


<210>  46
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG119*△SP

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile 
                245                 250                 255     


Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu 
            260                 265                 270         


Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg 
        275                 280                 285             


Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn 
    290                 295                 300                 


His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys 
305                 310                 315                 320 


Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe 
                325                 330                 335     


Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu 
            340                 345                 350         


Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro 
        355                 360                 365             


Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg 
    370                 375                 380                 


Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln 
385                 390                 395                 400 


Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser 
                405                 410                 415     


Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg 
            420                 425                 430         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        435                 440                 445             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    450                 455                 460                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
465                 470                 475                 480 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490     


<210>  47
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG120*

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser 
                85                  90                  95      


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe 
        115                 120                 125             


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn 
            260                 265                 270         


Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg 
        275                 280                 285             


Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His 
    290                 295                 300                 


Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu 
305                 310                 315                 320 


Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg 
                325                 330                 335     


Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp 
            340                 345                 350         


Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp 
        355                 360                 365             


Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu 
    370                 375                 380                 


Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu 
385                 390                 395                 400 


Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro 
                405                 410                 415     


Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile 
            420                 425                 430         


Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr 
        435                 440                 445             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    450                 455                 460                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
465                 470                 475                 480 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                485                 490                 495     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            500                 505                 510         


<210>  48
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG120*△SP

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala 
145                 150                 155                 160 


Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile 
                245                 250                 255     


Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu 
            260                 265                 270         


Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg 
        275                 280                 285             


Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn 
    290                 295                 300                 


His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys 
305                 310                 315                 320 


Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe 
                325                 330                 335     


Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu 
            340                 345                 350         


Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro 
        355                 360                 365             


Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg 
    370                 375                 380                 


Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln 
385                 390                 395                 400 


Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser 
                405                 410                 415     


Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg 
            420                 425                 430         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        435                 440                 445             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    450                 455                 460                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
465                 470                 475                 480 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490     


<210>  49
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG137*

<400>  49

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ile Asp Ala Met Gly Asn Ile Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Pro Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Arg Trp Met Gly Trp Ile Asn Thr His Thr Gly 
65                  70                  75                  80  


Glu Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu 
                85                  90                  95      


Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn 
            100                 105                 110         


Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Arg Gly Tyr Asp Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp 
            180                 185                 190         


Phe His His Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala 
        195                 200                 205             


Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Asp Tyr Glu Asp Met 
225                 230                 235                 240 


Gly Ile Tyr Tyr Cys Gln Gln Tyr Asp Glu Ser Pro Trp Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Met Lys Gly Ser Gly Asp Pro Ala Gly Ser 
            260                 265                 270         


Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala 
        275                 280                 285             


Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg 
    290                 295                 300                 


Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala 
305                 310                 315                 320 


Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly 
                325                 330                 335     


Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala 
            340                 345                 350         


Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val 
        355                 360                 365             


Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys 
    370                 375                 380                 


Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile 
385                 390                 395                 400 


Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu Gln Arg Val Gly His 
                405                 410                 415     


Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro 
            420                 425                 430         


Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly 
        435                 440                 445             


Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    450                 455                 460                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
465                 470                 475                 480 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                485                 490                 495     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            500                 505                 510         


Leu Leu Leu Ser Leu Val Ile Thr 
        515                 520 


<210>  50
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG137*△SP

<400>  50

Asp Ala Met Gly Asn Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys 
1               5                   10                  15      


Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
            20                  25                  30          


Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Arg Trp Met Gly Trp Ile Asn Thr His Thr Gly Glu Pro Thr Tyr 
    50                  55                  60                  


Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala 
65                  70                  75                  80  


Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala 
                85                  90                  95      


Thr Tyr Phe Cys Thr Arg Arg Gly Tyr Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe His His Lys 
                165                 170                 175     


Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Ser Leu Asp Tyr Glu Asp Met Gly Ile Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Asp Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Met Lys Gly Ser Gly Asp Pro Ala Gly Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala 
            260                 265                 270         


Lys Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu 
        275                 280                 285             


Ser Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu 
    290                 295                 300                 


Arg Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Ser His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys 
                325                 330                 335     


Tyr Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg 
            340                 345                 350         


Lys Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu 
        355                 360                 365             


Leu Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg 
    370                 375                 380                 


Lys Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val 
385                 390                 395                 400 


Thr Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met 
                405                 410                 415     


Lys Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp 
            420                 425                 430         


Tyr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        435                 440                 445             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    450                 455                 460                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
465                 470                 475                 480 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
                485                 490                 495     


Leu Val Ile Thr 
            500 


<210>  51
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG138*

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Phe Thr Tyr Tyr 
65                  70                  75                  80  


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Asp Glu Val Arg Gly Tyr Leu Asp Val Trp 
        115                 120                 125             


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Tyr Lys Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
        195                 200                 205             


Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser Gly Ser Gly Ser Gly 
            260                 265                 270         


Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
        275                 280                 285             


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
    290                 295                 300                 


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
305                 310                 315                 320 


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
                325                 330                 335     


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
            340                 345                 350         


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
        355                 360                 365             


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
    370                 375                 380                 


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
385                 390                 395                 400 


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
                405                 410                 415     


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
            420                 425                 430         


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
        435                 440                 445             


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    450                 455                 460                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
465                 470                 475                 480 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                485                 490                 495     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            500                 505                 510         


Val Ile Thr 
        515 


<210>  52
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG138*△SP

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Ala Ala Tyr Lys Asp Ile Gln Met Thr Gln Thr Thr 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Arg Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly 
                245                 250                 255     


Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn 
            260                 265                 270         


Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr 
        275                 280                 285             


Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys 
    290                 295                 300                 


Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln 
305                 310                 315                 320 


Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp 
                325                 330                 335     


Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro 
            340                 345                 350         


Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys 
        355                 360                 365             


Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His 
    370                 375                 380                 


Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr 
385                 390                 395                 400 


Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala 
                405                 410                 415     


Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro 
            420                 425                 430         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        435                 440                 445             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    450                 455                 460                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
465                 470                 475                 480 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 


<210>  53
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB052*

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ile Ile Thr Tyr Ala Gly Ser Asn Glu Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Ile Trp Val Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys 
                165                 170                 175     


Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp 
        195                 200                 205             


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
225                 230                 235                 240 


Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Gly Ser Gly Ser Gly 
            260                 265                 270         


Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
        275                 280                 285             


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
    290                 295                 300                 


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
305                 310                 315                 320 


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
                325                 330                 335     


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
            340                 345                 350         


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
        355                 360                 365             


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
    370                 375                 380                 


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
385                 390                 395                 400 


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
                405                 410                 415     


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
            420                 425                 430         


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
        435                 440                 445             


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    450                 455                 460                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
465                 470                 475                 480 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                485                 490                 495     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            500                 505                 510         


Val Ile Thr 
        515 


<210>  54
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB052*△SP

<400>  54

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Thr Tyr Ala Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ile Trp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val 
    130                 135                 140                 


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val 
145                 150                 155                 160 


Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly 
                245                 250                 255     


Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn 
            260                 265                 270         


Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr 
        275                 280                 285             


Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys 
    290                 295                 300                 


Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln 
305                 310                 315                 320 


Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp 
                325                 330                 335     


Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro 
            340                 345                 350         


Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys 
        355                 360                 365             


Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His 
    370                 375                 380                 


Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr 
385                 390                 395                 400 


Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala 
                405                 410                 415     


Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro 
            420                 425                 430         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        435                 440                 445             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    450                 455                 460                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
465                 470                 475                 480 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 


<210>  55
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB053*

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Asn Met His Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Arg Leu Glu Trp Met Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
145                 150                 155                 160 


Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
                165                 170                 175     


Arg Ser Ser Gln Ser Ile Val Tyr Ser Asn Gly Asn Thr Tyr Leu Gly 
            180                 185                 190         


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys 
        195                 200                 205             


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
225                 230                 235                 240 


Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Gly Ser Gly Ser Gly 
            260                 265                 270         


Arg Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys 
        275                 280                 285             


Lys Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser 
    290                 295                 300                 


Glu Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg 
305                 310                 315                 320 


Glu Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser 
                325                 330                 335     


His Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr 
            340                 345                 350         


Met Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys 
        355                 360                 365             


Lys Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu 
    370                 375                 380                 


Met Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys 
385                 390                 395                 400 


Asp Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr 
                405                 410                 415     


Arg Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys 
            420                 425                 430         


Glu Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
        435                 440                 445             


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    450                 455                 460                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
465                 470                 475                 480 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                485                 490                 495     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            500                 505                 510         


Val Ile Thr 
        515 


<210>  56
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB053*△SP

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Ile Val Tyr Ser Asn Gly Asn Thr Tyr Leu Gly Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly 
                245                 250                 255     


Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn 
            260                 265                 270         


Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr 
        275                 280                 285             


Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys 
    290                 295                 300                 


Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln 
305                 310                 315                 320 


Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp 
                325                 330                 335     


Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro 
            340                 345                 350         


Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys 
        355                 360                 365             


Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His 
    370                 375                 380                 


Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr 
385                 390                 395                 400 


Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala 
                405                 410                 415     


Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro 
            420                 425                 430         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        435                 440                 445             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    450                 455                 460                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
465                 470                 475                 480 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 


<210>  57
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A-GFP**(i.e. P2A-eGFP)

<400>  57

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
            20                  25                  30          


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
        35                  40                  45              


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
    50                  55                  60                  


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
65                  70                  75                  80  


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
                85                  90                  95      


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
            100                 105                 110         


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
        115                 120                 125             


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
    130                 135                 140                 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
145                 150                 155                 160 


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
                165                 170                 175     


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
            180                 185                 190         


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
        195                 200                 205             


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
    210                 215                 220                 


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
225                 230                 235                 240 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
                245                 250                 255     


Tyr Lys 
        


<210>  58
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2Rβjm(i.e. IL2Rβ jm DT or L2Rβ jm domain)

<400>  58

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu 
            20                  25          


<210>  59
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB014*(CD3ζ.△IC-IL2Rβjm)

<400>  59

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu 
    50                  55                  60                  


Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu 
65                  70                  75              


<210>  60
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB046 *(CD3ε.△IC -IL2Rβjm)

<400>  60

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Asn Cys Arg Asn Thr Gly Pro Trp 
145                 150                 155                 160 


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
                165                 170                 175     


Ser Gln Leu 
            


<210>  61
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3ζ.△IC

<400>  61

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu 
    50      


<210>  62
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAIL.IC

<400>  62

Tyr Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln 
1               5                   10                  15      


Arg Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu 
            20                  25                  30          


Arg Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser 
        35                  40                  45              


Cys Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile 
    50                  55                  60                  


Leu Thr Cys Asn His Ile Phe His Lys Thr Cys Val Asp Pro Trp Leu 
65                  70                  75                  80  


Leu Glu His Arg Thr Cys Pro Met Cys Lys Cys Asp Ile Leu Lys Ala 
                85                  90                  95      


Leu Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val Ser Leu Gln Val 
            100                 105                 110         


Pro Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser His Glu Glu Asp 
        115                 120                 125             


Asn Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser Val Gln Gly Thr 
    130                 135                 140                 


Asp Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr Asn Glu Ser Leu 
145                 150                 155                 160 


Gln Leu Val Asn His Glu Ala Asn Ser Val Ala Val Asp Val Ile Pro 
                165                 170                 175     


His Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr Pro Asn Gln Glu 
            180                 185                 190         


Thr Ala Val Arg Glu Ile Lys Ser 
        195                 200 


<210>  63
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG171 *(CD3ζ.△IC-GRAIL.IC)

<400>  63

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Tyr Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln Ser 
    50                  55                  60                  


Arg Lys Gln Arg Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly Arg 
65                  70                  75                  80  


Leu Gln Leu Arg Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro Asp 
                85                  90                  95      


Gly Asp Ser Cys Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp Leu 
            100                 105                 110         


Val Arg Ile Leu Thr Cys Asn His Ile Phe His Lys Thr Cys Val Asp 
        115                 120                 125             


Pro Trp Leu Leu Glu His Arg Thr Cys Pro Met Cys Lys Cys Asp Ile 
    130                 135                 140                 


Leu Lys Ala Leu Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val Ser 
145                 150                 155                 160 


Leu Gln Val Pro Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser His 
                165                 170                 175     


Glu Glu Asp Asn Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser Val 
            180                 185                 190         


Gln Gly Thr Asp Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr Asn 
        195                 200                 205             


Glu Ser Leu Gln Leu Val Asn His Glu Ala Asn Ser Val Ala Val Asp 
    210                 215                 220                 


Val Ile Pro His Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr Pro 
225                 230                 235                 240 


Asn Gln Glu Thr Ala Val Arg Glu Ile Lys Ser 
                245                 250     


<210>  64
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3ε.△IC

<400>  64

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser 
145                 150         


<210>  65
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB014.SP (i.e. the signal peptide of CD3ζ)

<400>  65

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala 
            20      


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB014.EM

<400>  66

Gln Ser Phe Gly Leu Leu Asp Pro Lys 
1               5                   


<210>  67
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB014.TM(i.e. the transmembrane domain of CD3ζ)

<400>  67

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  68
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB046.SP  (i.e. the signal peptide of CD3ε)

<400>  68

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln 
            20          


<210>  69
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB046.EM(i.e. the extracellular domain of CD3ε)

<400>  69

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp 
            100                 


<210>  70
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLB046.TM(i.e. the transmembrane domain of CD3ε)

<400>  70

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  71
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG212 *(CD3ε.△IC)

<400>  71

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser 
145                 150         


<210>  72
<211>  1733
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  72
ctcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca     1440

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     1500

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc     1560

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg     1620

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1680

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttg            1733


<210>  73
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG222*

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
        115                 120                 125             


Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                165                 170                 175     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
            180                 185                 190         


Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro 
    210                 215                 220                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
225                 230                 235                 240 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                245                 250                 255     


Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys Tyr Leu 
        275                 280                 285             


Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe 
    290                 295                 300                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Tyr Ser Ala Arg Arg Leu 
305                 310                 315                 320 


Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln Arg Gln Leu Lys Ala Asp 
                325                 330                 335     


Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu Arg Thr Leu Lys Gln Gly 
            340                 345                 350         


Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser Cys Ala Val Cys Ile Glu 
        355                 360                 365             


Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile Leu Thr Cys Asn His Ile 
    370                 375                 380                 


Phe His Lys Thr Cys Val Asp Pro Trp Leu Leu Glu His Arg Thr Cys 
385                 390                 395                 400 


Pro Met Cys Lys Cys Asp Ile Leu Lys Ala Leu Gly Ile Glu Val Asp 
                405                 410                 415     


Val Glu Asp Gly Ser Val Ser Leu Gln Val Pro Val Ser Asn Glu Ile 
            420                 425                 430         


Ser Asn Ser Ala Ser Ser His Glu Glu Asp Asn Arg Ser Glu Thr Ala 
        435                 440                 445             


Ser Ser Gly Tyr Ala Ser Val Gln Gly Thr Asp Glu Pro Pro Leu Glu 
    450                 455                 460                 


Glu His Val Gln Ser Thr Asn Glu Ser Leu Gln Leu Val Asn His Glu 
465                 470                 475                 480 


Ala Asn Ser Val Ala Val Asp Val Ile Pro His Val Asp Asn Pro Thr 
                485                 490                 495     


Phe Glu Glu Asp Glu Thr Pro Asn Gln Glu Thr Ala Val Arg Glu Ile 
            500                 505                 510         


Lys Ser 
        


<210>  74
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG222.1*

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
        115                 120                 125             


Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                165                 170                 175     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
            180                 185                 190         


Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro 
    210                 215                 220                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
225                 230                 235                 240 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                245                 250                 255     


Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Tyr 
            340                 345                 350         


Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln Arg 
        355                 360                 365             


Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu Arg 
    370                 375                 380                 


Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser Cys 
385                 390                 395                 400 


Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile Leu 
                405                 410                 415     


Thr Cys Asn His Ile Phe His Lys Thr Cys Val Asp Pro Trp Leu Leu 
            420                 425                 430         


Glu His Arg Thr Cys Pro Met Cys Lys Cys Asp Ile Leu Lys Ala Leu 
        435                 440                 445             


Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val Ser Leu Gln Val Pro 
    450                 455                 460                 


Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser His Glu Glu Asp Asn 
465                 470                 475                 480 


Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser Val Gln Gly Thr Asp 
                485                 490                 495     


Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr Asn Glu Ser Leu Gln 
            500                 505                 510         


Leu Val Asn His Glu Ala Asn Ser Val Ala Val Asp Val Ile Pro His 
        515                 520                 525             


Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr Pro Asn Gln Glu Thr 
    530                 535                 540                 


Ala Val Arg Glu Ile Lys Ser 
545                 550     


<210>  75
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG222.2*

<400>  75

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
        115                 120                 125             


Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                165                 170                 175     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
            180                 185                 190         


Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro 
    210                 215                 220                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
225                 230                 235                 240 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                245                 250                 255     


Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val 
        275                 280                 285             


Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu 
    290                 295                 300                 


Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Tyr Ser Ala Arg Arg Leu Arg 
                325                 330                 335     


Asn Ala Arg Ala Gln Ser Arg Lys Gln Arg Gln Leu Lys Ala Asp Ala 
            340                 345                 350         


Lys Lys Ala Ile Gly Arg Leu Gln Leu Arg Thr Leu Lys Gln Gly Asp 
        355                 360                 365             


Lys Glu Ile Gly Pro Asp Gly Asp Ser Cys Ala Val Cys Ile Glu Leu 
    370                 375                 380                 


Tyr Lys Pro Asn Asp Leu Val Arg Ile Leu Thr Cys Asn His Ile Phe 
385                 390                 395                 400 


His Lys Thr Cys Val Asp Pro Trp Leu Leu Glu His Arg Thr Cys Pro 
                405                 410                 415     


Met Cys Lys Cys Asp Ile Leu Lys Ala Leu Gly Ile Glu Val Asp Val 
            420                 425                 430         


Glu Asp Gly Ser Val Ser Leu Gln Val Pro Val Ser Asn Glu Ile Ser 
        435                 440                 445             


Asn Ser Ala Ser Ser His Glu Glu Asp Asn Arg Ser Glu Thr Ala Ser 
    450                 455                 460                 


Ser Gly Tyr Ala Ser Val Gln Gly Thr Asp Glu Pro Pro Leu Glu Glu 
465                 470                 475                 480 


His Val Gln Ser Thr Asn Glu Ser Leu Gln Leu Val Asn His Glu Ala 
                485                 490                 495     


Asn Ser Val Ala Val Asp Val Ile Pro His Val Asp Asn Pro Thr Phe 
            500                 505                 510         


Glu Glu Asp Glu Thr Pro Asn Gln Glu Thr Ala Val Arg Glu Ile Lys 
        515                 520                 525             


Ser 
    


<210>  76
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAIL.IC.ZF mutant (Zinc-finger→CD8a hinge)

<400>  76

Tyr Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln 
1               5                   10                  15      


Arg Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu 
            20                  25                  30          


Arg Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser 
        35                  40                  45              


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Cys Asp 
                85                  90                  95      


Ile Leu Lys Ala Leu Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val 
            100                 105                 110         


Ser Leu Gln Val Pro Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser 
        115                 120                 125             


His Glu Glu Asp Asn Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser 
    130                 135                 140                 


Val Gln Gly Thr Asp Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr 
145                 150                 155                 160 


Asn Glu Ser Leu Gln Leu Val Asn His Glu Ala Asn Ser Val Ala Val 
                165                 170                 175     


Asp Val Ile Pro His Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr 
            180                 185                 190         


Pro Asn Gln Glu Thr Ala Val Arg Glu Ile Lys Ser 
        195                 200                 


<210>  77
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAIL.IC.H2N2 mutant

<400>  77

Tyr Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln Ser Arg Lys Gln 
1               5                   10                  15      


Arg Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly Arg Leu Gln Leu 
            20                  25                  30          


Arg Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro Asp Gly Asp Ser 
        35                  40                  45              


Cys Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile 
    50                  55                  60                  


Leu Thr Cys Asn Arg Ile Phe Arg Lys Thr Cys Val Asp Pro Trp Leu 
65                  70                  75                  80  


Leu Glu His Arg Thr Cys Pro Met Cys Lys Cys Asp Ile Leu Lys Ala 
                85                  90                  95      


Leu Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val Ser Leu Gln Val 
            100                 105                 110         


Pro Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser His Glu Glu Asp 
        115                 120                 125             


Asn Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser Val Gln Gly Thr 
    130                 135                 140                 


Asp Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr Asn Glu Ser Leu 
145                 150                 155                 160 


Gln Leu Val Asn His Glu Ala Asn Ser Val Ala Val Asp Val Ile Pro 
                165                 170                 175     


His Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr Pro Asn Gln Glu 
            180                 185                 190         


Thr Ala Val Arg Glu Ile Lys Ser 
        195                 200 


<210>  78
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF133

<400>  78

Met His Leu Leu Lys Val Gly Thr Trp Arg Asn Asn Thr Ala Ser Ser 
1               5                   10                  15      


Trp Leu Met Lys Phe Ser Val Leu Trp Leu Val Ser Gln Asn Cys Cys 
            20                  25                  30          


Arg Ala Ser Val Val Trp Met Ala Tyr Met Asn Ile Ser Phe His Val 
        35                  40                  45              


Gly Asn His Val Leu Ser Glu Leu Gly Glu Thr Gly Val Phe Gly Arg 
    50                  55                  60                  


Ser Ser Thr Leu Lys Arg Val Ala Gly Val Ile Val Pro Pro Glu Gly 
65                  70                  75                  80  


Lys Ile Gln Asn Ala Cys Asn Pro Asn Thr Ile Phe Ser Arg Ser Lys 
                85                  90                  95      


Tyr Ser Glu Thr Trp Leu Ala Leu Ile Glu Arg Gly Gly Cys Thr Phe 
            100                 105                 110         


Thr Gln Lys Ile Lys Val Ala Thr Glu Lys Gly Ala Ser Gly Val Ile 
        115                 120                 125             


Ile Tyr Asn Val Pro Gly Thr Gly Asn Gln Val Phe Pro Met Phe His 
    130                 135                 140                 


Gln Ala Phe Glu Asp Val Val Val Val Met Ile Gly Asn Leu Lys Gly 
145                 150                 155                 160 


Thr Glu Ile Phe His Leu Ile Lys Lys Gly Val Leu Ile Thr Ala Val 
                165                 170                 175     


Val Glu Val Gly Arg Lys His Ile Ile Trp Met Asn His Tyr Leu Val 
            180                 185                 190         


Ser Phe Val Ile Val Thr Thr Ala Thr Leu Ala Tyr Phe Ile Phe Tyr 
        195                 200                 205             


His Ile His Arg Leu Cys Leu Ala Arg Ile Gln Asn Arg Arg Trp Gln 
    210                 215                 220                 


Arg Leu Thr Thr Asp Leu Gln Asn Thr Phe Gly Gln Leu Gln Leu Arg 
225                 230                 235                 240 


Val Val Lys Glu Gly Asp Glu Glu Ile Asn Pro Asn Gly Asp Ser Cys 
                245                 250                 255     


Val Ile Cys Phe Glu Arg Tyr Lys Pro Asn Asp Ile Val Arg Ile Leu 
            260                 265                 270         


Thr Cys Lys His Phe Phe His Lys Asn Cys Ile Asp Pro Trp Ile Leu 
        275                 280                 285             


Pro His Gly Thr Cys Pro Ile Cys Lys Cys Asp Ile Leu Lys Val Leu 
    290                 295                 300                 


Gly Ile Gln Val Val Val Glu Asn Gly Thr Glu Pro Leu Gln Val Leu 
305                 310                 315                 320 


Met Ser Asn Glu Leu Pro Glu Thr Leu Ser Pro Ser Glu Glu Glu Thr 
                325                 330                 335     


Asn Asn Glu Val Ser Pro Ala Gly Thr Ser Asp Lys Val Ile His Val 
            340                 345                 350         


Glu Glu Asn Pro Thr Ser Gln Asn Asn Asp Ile Gln Pro His Ser Val 
        355                 360                 365             


Val Glu Asp Val His Pro Ser Pro 
    370                 375     


<210>  79
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF133.IC

<400>  79

His Arg Leu Cys Leu Ala Arg Ile Gln Asn Arg Arg Trp Gln Arg Leu 
1               5                   10                  15      


Thr Thr Asp Leu Gln Asn Thr Phe Gly Gln Leu Gln Leu Arg Val Val 
            20                  25                  30          


Lys Glu Gly Asp Glu Glu Ile Asn Pro Asn Gly Asp Ser Cys Val Ile 
        35                  40                  45              


Cys Phe Glu Arg Tyr Lys Pro Asn Asp Ile Val Arg Ile Leu Thr Cys 
    50                  55                  60                  


Lys His Phe Phe His Lys Asn Cys Ile Asp Pro Trp Ile Leu Pro His 
65                  70                  75                  80  


Gly Thr Cys Pro Ile Cys Lys Cys Asp Ile Leu Lys Val Leu Gly Ile 
                85                  90                  95      


Gln Val Val Val Glu Asn Gly Thr Glu Pro Leu Gln Val Leu Met Ser 
            100                 105                 110         


Asn Glu Leu Pro Glu Thr Leu Ser Pro Ser Glu Glu Glu Thr Asn Asn 
        115                 120                 125             


Glu Val Ser Pro Ala Gly Thr Ser Asp Lys Val Ile His Val Glu Glu 
    130                 135                 140                 


Asn Pro Thr Ser Gln Asn Asn Asp Ile Gln Pro His Ser Val Val Glu 
145                 150                 155                 160 


Asp Val His Pro Ser Pro 
                165     


<210>  80
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF122

<400>  80

Met His Pro Phe Gln Trp Cys Asn Gly Cys Phe Cys Gly Leu Gly Leu 
1               5                   10                  15      


Val Ser Thr Asn Lys Ser Cys Ser Met Pro Pro Ile Ser Phe Gln Asp 
            20                  25                  30          


Leu Pro Leu Asn Ile Tyr Met Val Ile Phe Gly Thr Gly Ile Phe Val 
        35                  40                  45              


Phe Met Leu Ser Leu Ile Phe Cys Cys Tyr Phe Ile Ser Lys Leu Arg 
    50                  55                  60                  


Asn Gln Ala Gln Ser Glu Arg Tyr Gly Tyr Lys Glu Val Val Leu Lys 
65                  70                  75                  80  


Gly Asp Ala Lys Lys Leu Gln Leu Tyr Gly Gln Thr Cys Ala Val Cys 
                85                  90                  95      


Leu Glu Asp Phe Lys Gly Lys Asp Glu Leu Gly Val Leu Pro Cys Gln 
            100                 105                 110         


His Ala Phe His Arg Lys Cys Leu Val Lys Trp Leu Glu Val Arg Cys 
        115                 120                 125             


Val Cys Pro Met Cys Asn Lys Pro Ile Ala Ser Pro Ser Glu Ala Thr 
    130                 135                 140                 


Gln Asn Ile Gly Ile Leu Leu Asp Glu Leu Val 
145                 150                 155 


<210>  81
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF122.rIC

<400>  81

Ser Lys Leu Arg Asn Gln Ala Gln Ser Glu Arg Tyr Gly Tyr Lys Glu 
1               5                   10                  15      


Val Val Leu Lys Gly Asp Ala Lys Lys Leu Gln Leu Tyr Gly Gln Thr 
            20                  25                  30          


Cys Ala Val Cys Leu Glu Asp Phe Lys Gly Lys Asp Glu Leu Gly Val 
        35                  40                  45              


Leu Pro Cys Gln His Ala Phe His Arg Lys Cys Leu Val Lys Trp Leu 
    50                  55                  60                  


Glu Val Arg Cys Val Cys Pro Met Cys Asn Lys Pro Ile Ala Ser Pro 
65                  70                  75                  80  


Ser Glu Ala Thr Gln Asn Ile Gly Ile Leu Leu Asp Glu Leu Val 
                85                  90                  95  


<210>  82
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF152

<400>  82

Met Glu Thr Leu Ser Gln Asp Ser Leu Leu Glu Cys Gln Ile Cys Phe 
1               5                   10                  15      


Asn Tyr Tyr Ser Pro Arg Arg Arg Pro Lys Leu Leu Asp Cys Lys His 
            20                  25                  30          


Thr Cys Cys Ser Val Cys Leu Gln Gln Met Arg Thr Ser Gln Lys Asp 
        35                  40                  45              


Val Arg Cys Pro Trp Cys Arg Gly Val Thr Lys Leu Pro Pro Gly Phe 
    50                  55                  60                  


Ser Val Ser Gln Leu Pro Asp Asp Pro Glu Val Leu Ala Val Ile Ala 
65                  70                  75                  80  


Ile Pro His Thr Ser Glu His Thr Pro Val Phe Ile Lys Leu Pro Ser 
                85                  90                  95      


Asn Gly Cys Tyr Met Leu Pro Leu Pro Ile Ser Lys Glu Arg Ala Leu 
            100                 105                 110         


Leu Pro Gly Asp Met Gly Cys Arg Leu Leu Pro Gly Ser Gln Gln Lys 
        115                 120                 125             


Ser Val Thr Val Val Thr Ile Pro Ala Glu Gln Gln Pro Leu Gln Gly 
    130                 135                 140                 


Gly Ala Pro Gln Glu Ala Val Glu Glu Glu Gln Asp Arg Arg Gly Val 
145                 150                 155                 160 


Val Lys Ser Ser Thr Trp Ser Gly Val Cys Thr Val Ile Leu Val Ala 
                165                 170                 175     


Cys Val Leu Val Phe Leu Leu Gly Ile Val Leu His Asn Met Ser Cys 
            180                 185                 190         


Ile Ser Lys Arg Phe Thr Val Ile Ser Cys Gly 
        195                 200             


<210>  83
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF152.rIC

<400>  83

Trp Thr Ser Ser Lys Val Val Gly Arg Arg Asp Gln Glu Glu Glu Val 
1               5                   10                  15      


Ala Glu Gln Pro Ala Gly Gly Gln Leu Pro Gln Gln Glu Ala Pro Ile 
            20                  25                  30          


Thr Val Val Thr Val Ser Lys Gln Gln Ser Gly Pro Leu Leu Arg Cys 
        35                  40                  45              


Gly Met Asp Gly Pro Leu Leu Ala Arg Glu Lys Ser Ile Pro Leu Pro 
    50                  55                  60                  


Leu Met Tyr Cys Gly Asn Ser Pro Leu Lys Ile Phe Val Pro Thr His 
65                  70                  75                  80  


Glu Ser Thr His Pro Ile Ala Ile Val Ala Leu Val Glu Pro Asp Asp 
                85                  90                  95      


Pro Leu Gln Ser Val Ser Phe Gly Pro Pro Leu Lys Thr Val Gly Arg 
            100                 105                 110         


Cys Trp Pro Cys Arg Val Asp Lys Gln Ser Thr Arg Met Gln Gln Leu 
        115                 120                 125             


Cys Val Ser Cys Cys Thr His Lys Cys Asp Leu Leu Lys Pro Arg Arg 
    130                 135                 140                 


Arg Pro Ser Tyr Tyr Asn Phe Cys Ile Gln Cys Glu Leu Leu Ser Asp 
145                 150                 155                 160 


Gln Ser Leu Thr Glu 
                165 


<210>  84
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRAIL- zinc-finger domain

<400>  84

Cys Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp Leu Val Arg Ile 
1               5                   10                  15      


Leu Thr Cys Asn His Ile Phe His Lys Thr Cys Val Asp Pro Trp Leu 
            20                  25                  30          


Leu Glu His Arg Thr Cys Pro Met Cys Lys 
        35                  40          


<210>  85
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8  hinge

<400>  85

Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45      


<210>  86
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG116*

<400>  86

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            180                 185                 190         


Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        195                 200                 205             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                245                 250                 255     


Lys Leu Gln Ile Thr Arg Gly Ser Gly Ser Gly Ser Gly Ser Val Asn 
            260                 265                 270         


Ile Ser Gly Gln Asn Thr Met Asn Met Val Lys Val Pro Glu Cys Arg 
        275                 280                 285             


Leu Ala Asp Glu Leu Gly Gly Leu Trp Glu Asn Ser Arg Phe Thr Asp 
    290                 295                 300                 


Cys Cys Leu Cys Val Ala Gly Gln Glu Phe Gln Ala His Lys Ala Ile 
305                 310                 315                 320 


Leu Ala Ala Arg Ser Pro Val Phe Ser Ala Met Phe Glu His Glu Met 
                325                 330                 335     


Glu Glu Ser Lys Lys Asn Arg Val Glu Ile Asn Asp Val Glu Pro Glu 
            340                 345                 350         


Val Phe Lys Glu Met Met Cys Phe Ile Tyr Thr Gly Lys Ala Pro Asn 
        355                 360                 365             


Leu Asp Lys Met Ala Asp Asp Leu Leu Ala Ala Ala Asp Lys Tyr Ala 
    370                 375                 380                 


Leu Glu Arg Leu Lys Val Met Cys Glu Asp Ala Leu Cys Ser Asn Leu 
385                 390                 395                 400 


Ser Val Glu Asn Ala Ala Glu Ile Leu Ile Leu Ala Asp Leu His Ser 
                405                 410                 415     


Ala Asp Gln Leu Lys Thr Gln Ala Val Asp Phe Ile Asn Tyr His Ala 
            420                 425                 430         


Ser Asp Val Leu Glu Thr Ser Gly Trp Lys Ser Met Val Val Ser His 
        435                 440                 445             


Pro His Leu Val Ala Glu Ala Tyr Arg Ser Leu Ala Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Leu Gly Pro Pro Arg Lys Arg Leu Lys Gln Ser Gly Thr Thr 
465                 470                 475                 480 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
                485                 490                 495     


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
            500                 505                 510         


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
        515                 520                 525             


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
    530                 535                 540                 


<210>  87
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LG118*

<400>  87

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser 
        115                 120                 125             


Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                165                 170                 175     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
            180                 185                 190         


Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro 
    210                 215                 220                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
225                 230                 235                 240 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                245                 250                 255     


Ala Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu Gly Ser Gly Ser Gly Ser Gly Arg Leu Asn Phe Gly Asp 
        275                 280                 285             


Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys Lys Arg Trp Asn Ser 
    290                 295                 300                 


Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu Leu His Ser Tyr Leu 
305                 310                 315                 320 


Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu Leu Glu Glu Cys Gln 
                325                 330                 335     


Arg Asn His Glu Gly Asp Glu Asp Asp Ser His Val Arg Ala Gln Gln 
            340                 345                 350         


Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met Ala Asp Met Asp Glu 
        355                 360                 365             


Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys Arg Asp Ile Pro Asp 
    370                 375                 380                 


Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met Arg Glu Pro Cys Ile 
385                 390                 395                 400 


Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp Ile Glu Glu His Leu 
                405                 410                 415     


Gln Arg Val Gly His Phe Asp Pro Val Thr Arg Ser Pro Leu Thr Gln 
            420                 425                 430         


Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu Val Ile Asp Ala Phe 
        435                 440                 445             


Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr Gly Thr Thr Thr Pro Ala 
    450                 455                 460                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
465                 470                 475                 480 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                485                 490                 495     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            500                 505                 510         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        515                 520                 525 


<210>  88
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1α promotor

<400>  88
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc      240

ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg cccctggctg      300

cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag ttcgaggcct      360

tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcctgg gcgctggggc      420

cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga taagtctcta      480

gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga tagtcttgta      540

aatgcgggcc aagatctgca cactggtatt tcggtttttg gggccgcggg cggcgacggg      600

gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg gccaccgaga      660

atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct cgcgccgccg      720

tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc gtgagcggaa      780

agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg gcgctcggga      840

gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc agccgtcgct      900

tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt cttttggagt      960

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     1020

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     1080

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     1140

ccatttcag                                                             1149


<210>  89
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3ζ transmembrane domain variant(used in LG222,i.e. 
       CD3ζ.ΔIC-1)

<400>  89

Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly 
1               5                   10                  15      


Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu 
            20                  25                  30  


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular domain (used in LG222, LG222.1, LG222.2)

<400>  90

Arg Val Lys Phe Ser Arg Ser Ala Asp 
1               5                   


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker between scFv and E3 ligase or between CD8 TM and E3 ligase

<400>  91

Gly Ser Gly Ser Gly Ser Gly 
1               5           


