                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CCR8

<130>  1

<150>  CN202010953820.8
<151>  2020-09-11

<150>  CN202110238621.3
<151>  2021-03-04

<150>  CN202110270555.8
<151>  2021-03-12

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  353
<212>  PRT
<213>  Mus musculus

<400>  1

Met Asp Tyr Thr Met Glu Pro Asn Val Thr Met Thr Asp Tyr Tyr Pro 
1               5                   10                  15      


Asp Phe Phe Thr Ala Pro Cys Asp Ala Glu Phe Leu Leu Arg Gly Ser 
            20                  25                  30          


Met Leu Tyr Leu Ala Ile Leu Tyr Cys Val Leu Phe Val Leu Gly Leu 
        35                  40                  45              


Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Gly Cys Lys Lys Leu 
    50                  55                  60                  


Arg Ser Ile Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ala Ser Asp Leu 
65                  70                  75                  80  


Leu Phe Val Leu Ser Ile Pro Phe Gln Thr His Asn Leu Leu Asp Gln 
                85                  90                  95      


Trp Val Phe Gly Thr Ala Met Cys Lys Val Val Ser Gly Leu Tyr Tyr 
            100                 105                 110         


Ile Gly Phe Phe Ser Ser Met Phe Phe Ile Thr Leu Met Ser Val Asp 
        115                 120                 125             


Arg Tyr Leu Ala Ile Val His Ala Val Tyr Ala Ile Lys Val Arg Thr 
    130                 135                 140                 


Ala Ser Val Gly Thr Ala Leu Ser Leu Thr Val Trp Leu Ala Ala Val 
145                 150                 155                 160 


Thr Ala Thr Ile Pro Leu Met Val Phe Tyr Gln Val Ala Ser Glu Asp 
                165                 170                 175     


Gly Met Leu Gln Cys Phe Gln Phe Tyr Glu Glu Gln Ser Leu Arg Trp 
            180                 185                 190         


Lys Leu Phe Thr His Phe Glu Ile Asn Ala Leu Gly Leu Leu Leu Pro 
        195                 200                 205             


Phe Ala Ile Leu Leu Phe Cys Tyr Val Arg Ile Leu Gln Gln Leu Arg 
    210                 215                 220                 


Gly Cys Leu Asn His Asn Arg Thr Arg Ala Ile Lys Leu Val Leu Thr 
225                 230                 235                 240 


Val Val Ile Val Ser Leu Leu Phe Trp Val Pro Phe Asn Val Ala Leu 
                245                 250                 255     


Phe Leu Thr Ser Leu His Asp Leu His Ile Leu Asp Gly Cys Ala Thr 
            260                 265                 270         


Arg Gln Arg Leu Ala Leu Ala Ile His Val Thr Glu Val Ile Ser Phe 
        275                 280                 285             


Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Ile Gly Glu Lys 
    290                 295                 300                 


Phe Lys Lys His Leu Met Asp Val Phe Gln Lys Ser Cys Ser His Ile 
305                 310                 315                 320 


Phe Leu Tyr Leu Gly Arg Gln Met Pro Val Gly Ala Leu Glu Arg Gln 
                325                 330                 335     


Leu Ser Ser Asn Gln Arg Ser Ser His Ser Ser Thr Leu Asp Asp Ile 
            340                 345                 350         


Leu 
    


<210>  2
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  3
<211>  5236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homology arm

<400>  3
acactcaacc ttgttgtctt gtggttgtat cttcaatgat atgtggcaat atccctataa       60

acagcacttt ccctgggctg atctgtcaga ccttctgtaa cttatgtggg aaattaaact      120

gattagatgg caaagacttt tctgataggt tcgttctact attgataata caagagcttt      180

tagttaaatt ttatttattt atctctgtat gagcttttgt taaatacagg tttccatgtg      240

caaactcttg taagcaaatg ctaggagatt tgtagttgga agtgagagtg ttactgtaaa      300

taacaaacag aggtctactc caaagaaaag cagtgttgat ttgaaaagag tgcaatgtta      360

caacgtgcag cgagattcac agtaaccacc agtttataca atgagcatgg agcatggcaa      420

atccagaaac acaaaaatga aggttgagta agatactgag aaacagtatc cctggcctcg      480

aggattaatc caaatgttgc cagtctgagg ctgaggccat agtggaggga aagctgtccc      540

agagatgttt tctttgtaag gttgtggggg cattgtgtgg ggtgtggttt ggacagtggt      600

ttgttagcaa ggtttatttt atttaaggct acagagacaa ggcggggatt aagaaggctg      660

ttgctcttgc agaggcccca aggttaattc ccagcactca catggtggct cataactcca      720

gcttcagggc atcctatgcc ctctactggc ttctgtgggc actgcataca tgtgacattt      780

actctcgtac acaaatgtag agataaaaat aaaactgcat cccttattaa aagagtttat      840

ttgcgtgtga tgcgcaccca tgcgcgcgtg tttgcttatc tgagtggtcc tgtagaggtc      900

agtagaggca ggatgcatca gtctctgcct cctcctgaaa cagaggctct cacagaactc      960

atgatttctg tgatcggctg gactctagca aacctagaac cctgtcatct ttgctcttct     1020

tagagctggg gttacaagct tttgcaggaa cgtcggcttg ttacacaggt gctgggaacc     1080

aaattctggt cctcatgatt tataagggag tactcttcac tgctgagccg ttctttctat     1140

ctgtggcaga agttctgtgt cagtgccttt gggagtatgt gagaaccctt ccaatgcaac     1200

ctcatggttc atttgtttgt tcctcctttc ttggttcatt cattcattaa ttcttttttt     1260

tccccccatc cttcttcctc aggtggttct aacatgcctt gctttcaaag atttaaagat     1320

tttaaagatt tatttcgtgt gaacaggtct tttgcctgag tgtctgtctg tgcaccacat     1380

gcgtgctggg tactggagaa ggccagaaga gggcatagca tctcctaaac tggatttaaa     1440

gccagttgtg tgttgccagc cacgtggggg ctgggaatga acccaggtgc tttggaagca     1500

gagcagccgg tgacactctt acttgtggag ccactctccg gctcctttat gtcacatttg     1560

ggtcacacaa gccactccat ctcagttctg agaattttca taacagataa tcctaaaaga     1620

gttttttcta atgtcatctg tcttttagtt ttaatgcagg ttaataagag gggccccctg     1680

agctgtgctt caggaagctt cagtgtaggc tctggcctta ccaccaaata gctgtgtgtg     1740

tgtgtgtgtg tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tatgagagcg tgtgtgtgtg     1800

tactcgagtg tgtgtgtgtg tgtgtgtgag agagagagag agagagagag agagagtgtg     1860

tgactgtgtg tgtgtatgtg tgtgactgtg tgattgtgtg tgtgtgcacg cccttgcccc     1920

tgtgtttctg tatgtgtgta ctttgcctgc ccagtctctc cccattgtgc tgtgatactg     1980

gagtgattca tttcacgtcc atggaactaa acattcagaa cgaaagaggt tgagtgtgag     2040

agaaagacag actggcaggc tgtcttagtt agggttttat tgctgtgaac agacaccatg     2100

accaaggcaa ctcttataag gacaacactt agtaggggct ggcttactgg gtcagaggtt     2160

cagtccatta tcatcatggt gggaagcatg gcagcatcca ggcaggcatg gtgcatgagc     2220

tgagatttct acatcttcat ctgaaggctg ctagtggaag actcacttcc aggcagctag     2280

gatgagggcc ttaaagccca cactcacagt gaatgacaca cctactccaa caaggccaca     2340

cctctcaata gtaccactcc ctgggccaag catataaaaa ccatcacaaa gtcatggata     2400

gatcccaaga cagtaattcc agtattcagg aggcagagtc aggcagacct ctaagtgcta     2460

ggccagccta gtctacatag ggaagtccag gctagcttaa tctacacaga ggggactaac     2520

acacagggag aggacagatt tgtgagtggc cctgctgggc aggggtggca gccagttgtc     2580

tctgacctgg cacatcaccg atggagttgg attcatactt tccattaccc cgacgagcat     2640

cagcagcacc tgagagtccg ctgttcacag tcagctcggc actgacattt tcttatcgct     2700

attctgtctt aaaggccggg gcttgcccca agctctgtta aaacctcttg gtgaggagaa     2760

tcataggcat gatctgaggt gtcagagatg cttctaaatg ataaactcac tcgttgtcag     2820

aagacagatt cacgggtcac agagcagaag ctgagaggaa catgctgtca cctgaatagt     2880

gagtgtccaa gtgccgaggc cagagagggg aacacatgcc tgcagctcta gttcccaggg     2940

aggcagagtt atgtggctcc ctggggctca ctggtaacca acctagccca tttcaggaga     3000

cccaaactag agagagacca catcaaaaca acagaagcaa atggtaagag acactaagag     3060

caaacgttct gctgagcagc agtggtgtac gcctttaatc ccagtattcc agaggcctag     3120

gcaggtggct ctcggagttc aaggccagcc tgctctacag aatgagttct aagacagcca     3180

ctgttctgca gagaaaccct gttttgaaca acaaaacaaa caaacaagca aacaaacaaa     3240

caggaactaa gagtagatgg acagattccc tcccatacca ccatccagag gaaaggtgat     3300

gccccctgct tatctctgcc ccagatctga ggtgaaaaga caggaagaag gtactgagag     3360

tcaaggagcc ctggttgcat agcacgctgt tccattgctc tggagacagg gtgggtctgt     3420

cccaaacagc agaggggttg gggctgtaag tcagaggtag ctcttactgt tccaaccttt     3480

ggattggctg aggcatggca tatagctgaa gtgctcagga ggaggagtca gcacagcaag     3540

cagacatgtg gcagaggagt gggcagctct gaaacctcag aagaaaggct cgctcagata     3600

attggtaaga atcatccttg gggttagggc tcagaggcag tgcgggcacc gttttcatct     3660

ccttacagag agatcaggag aaggctgata tttcgggatc ataagagttt tgagtgtctc     3720

caaagcctga gcccacaagc gcgtgtgtct cttggtggct gataggagca tgtcccttgt     3780

tctccaggac acagaaaggg ctgaaagctc tcacaggagt aaaaaaatta gacaagacag     3840

cattttctgg cgatcatcct ttctccacag aaaacttcca ttcaatccca cctccttgta     3900

tgtctgtcaa tggagtctta gactctgcat tgtgtggggt gtggggaacg ggacctagga     3960

cctggctcgg gtcctaagca tgtgctgtgc ccccaggccc tgtaatgttt tatttcgtgg     4020

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgagaata tgtgagtgtg cgcatgtaca     4080

ggaggtcaga ggccagcctt ggtgctatgt ttcaggcgct ctcccctcgc tttgtgctca     4140

ccaagcaggc caggctggcc agggccacgg agctctgcct gtctctgcct cccctgcgtg     4200

ggcattgcga gcacacactg ccacgcatgg gtttaggggt ttgaactgag gtctccatgg     4260

ttgcttagca agcacctcgc ttacggagat atcccctcag ccccagtgtt tgacacgact     4320

gaattccagc ctttaccagg cttacctctg gcgaacccgg tgcttctcgt tttgagagga     4380

attgggatca tttttttttc ctattgcact ttaaatcgtt ttgagggggg ggggttatgg     4440

aagcaatgag tgaatgaact aaattcaaga atatcatagg atacatccga agcaaaatac     4500

aaaatgagac atcatatatg cagcatagga atgagtaagc aaatgttgtc tgttgaatac     4560

atatatactt tgtttgtttg agacagggct tctctgtgta gccctggctg tcctggaacc     4620

cactctgtag accaagctag cctcaaactc agagagccac cctcttctgc ctcccaagtg     4680

ctgggactaa agatgtgtat caacacacct ggcctgtatt ttgtttgtgg atccataaaa     4740

tgaaagagaa accaggcaga gtggcgcgtg cttttcatcc cagcacctgg gaagcagagg     4800

caggtgaatc tctgggagtt tgaggtcagc ttggtctata tagtaagttc caggacaact     4860

agggctatat agtgagacta tctaaaaata ccaaaattga ctaattacaa tgggggggtg     4920

ggggagagag agagagagag agaggccaag caaggtggta cagatctgta atacctccac     4980

tgagaaggct gaggcaggag gatcatgagt agtctgggct atgtagcaag ttccatacca     5040

gcccaaacca cttagtgaga ccttgtatga aggaagcaag gtctagggag aacagcttga     5100

tgggagagcg cttgccgcac actaacaccc tgacattgag ccgcagggag aaaggggagg     5160

tgtttaaggg cttcaatctg tgaatacagc cctcagcacc tctcacgtgc ctgcttgacc     5220

aggtcttcct gcctcg                                                     5236


<210>  4
<211>  3851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homology arm

<400>  4
ctgagaactg gacccagggg ctggagagat ggctcagtgg ttaagagcac cgactgctct       60

tccgaaggtc ctgagttcaa atcccagcaa ccacatggtg gctcacaacc atccataatg      120

agatctgacg ccctcttctg gtgcgtctga agatagctac agcgtactta gatataataa      180

taaataaatc ttaggaaaaa aaaaaagaaa aaaaaaaaga gaactggacc cagttctcag      240

cacccacatg gtggttcaaa ccatctgcaa ctccagtttc aggggatctg gcgtccccgt      300

ctggttctgt ggactctagg aacacatata gggagcatac ataactgcag gcaaaacact      360

tatacacata gaatagagta aaataaaatc tattctctga aatggtaaaa aaaaaaaggt      420

atttgtgtga aaaaatggca ttacttgctc tttgaaggtt tgatacaact tattaataaa      480

ccaatccagg gtacttctgt acaaagattt gcatttaatt accaaatgga agcgttcagc      540

ctttttatct gcttgtggtt tgtaagaaat tctgctattc tccttaagtt cacaagtaca      600

tgagtacgaa ttcttgacaa ttaattttgt tgaacaatct ttttgtagta tgagggtgtc      660

cctttctggt cctgatactg atcattgtgg ctcccccccc cacccccgtc tcctcctccc      720

ctccctccct cccctctcct agatcagttt tgtaggactt atctgttgct taaatctctg      780

catcgagcca gcctttggcc tcgctgactt cctgtctcct ctgctcgttg atttctgttt      840

ttattttcat ttcacctatt tgctttgagc ctggttttta tatgggctcc tggaatcgtc      900

tattgtctca gtattcactt ggggtgcatt ttacacattt taagtttggt cttagccaga      960

agtctgagaa gtagtcgtct actcctgcct tagccactgt tctactgctg tgaagagacg     1020

ccgtggctaa agcaacttat agaagaagac atttaactgg gggcttgttc aaagcttcag     1080

agggtttatc accatggcgg ggagcagggt ggcaggcagg gaggcatggt gagagaagca     1140

gctaggagct ttccatcctg atccacagcc aggagagaga gagagagaga gagagagaga     1200

gagagagaga gagacagaga cagagacaga gacacagagg agagacacag agagacagag     1260

agacagagag agacagagag acagcgcttc ttcaacaagg caacacacct tctaatcctt     1320

ttcaacactt caccaccaac tgggggctaa gtatgcaaat atatgagcct atggggctca     1380

cttaaaccac cacaaccagc agaaatgtta ttatatcaag aattcaaatt attctggaaa     1440

gtaaagaaga attcataaca ttgagaagaa aaaaaccacg acaacttcat acagtattta     1500

cttacactct tctcagagaa catacacata gggttttatt cctttaagat atatcaagaa     1560

ttattttatg atgcaagaca tggtttccat tcacccgtga aggtaacagg ttgcttctgc     1620

aggtagctag tcacgcagtt cgaggcttct gtgttctcgc tctttttctg attttttttt     1680

cctttctgca gctatcttgt tgcttttgtg aatcggggag tttaatgagg gttgctttca     1740

gaggtctgtg ggtgaagagc gttttgcagg aacaagagca actaccactg gtcacatcac     1800

tgaagaaaat gtctgcccac taagactttt gtactcttta tttgtttaaa acaactttta     1860

tttttatttt tatttttatt tattttttat ttttggtttt ttgagacaag gtttctctgt     1920

atagccctgg ctgtcctgga actcactttg ttgaccaagc tggcctcgaa ctcccaagta     1980

ctgggactaa aagtgtgtgc cgccaccacc cggcacaact gttatcttat tttttttttt     2040

taaatgtgat ttattatgag tgtagagatc agatcagagg acaacttgca agagttggcc     2100

ctgtcttccc agcgcatggg tctcagggat ggagtccagg caccttcccc tttgagcggc     2160

tgcacaggct gaatccttgg tgatttcccc ctggttgttt atcccatgag tcgataggag     2220

aggcactgca aaacacccaa ctctgattat ggcttattta ttttccattt taattctgtt     2280

tgtttttact gtatgttttg aagctgtttt tttttttaag atttttttat ttatatgagt     2340

actttgtagc tgtcttcaga cacaccagaa gaaggcatcg gatcccacta cagatggttg     2400

tgagccacca tgtggttgct gggaattgaa ctcaggacct ctggaagagc agttggtgtt     2460

cttaaccact gagccatctc tccagccact gaagctgtta ttagtatgga caaataaaga     2520

attgttctgc atgtttttaa accaaatagc ctcttttgtt attatgaaat ttcctttgtg     2580

ttctttttga gaggtaagta ggtgggtttg agacaggatc tatctatata gccctagcta     2640

tcctggaact cactgtgtag tccaggctag ccttgaactc acagagctcc acatacctct     2700

gccttcagag tgctaggatt aaaagcacga gtcaccatgt ctggccgaat aaatatttct     2760

acaaagcaag tttgaggtta gcctaggata cagaagaccc tgttcccccc cacacaaaaa     2820

aaaagtttaa ggaaagataa aattatttat tgttatggca agaggttgcc aagttggaat     2880

cttagagtag gatgttgccg aagccacagg ctcatagctc atcagttgta tcagctagca     2940

aggccaccat cttcctcaca gtctccatgc ttctctgact gaaccttgca agcacccagt     3000

gggcaacatg ctgtgtgggg tgggacaggc aactctgcag tgtgtgtgag acatggggag     3060

tggagagggg cttcctccga catttttcaa gactgtcagc ttccaggagt cctgctcaga     3120

tggttcttat ttagcaagag tcactcgggc atcttgagtc acactaagct ttctgatggg     3180

gcaaggacct gacttggtcc agctgcatcc cttacagctg gcctcaggta agctctctga     3240

actccaagag gccgtgggta agagggggtg gagtgagcgg agacagaggg accatctgtc     3300

ctgcctgccc acacagctgc ctgatatcct tacagaaccc gtcaactccc ttcatacatt     3360

taaacgaaaa atcttagtaa cgtgatgaaa taaacagcgg acaggttagg acttgtttgt     3420

ttgtttgtgc gtttgtttgt tttcttttgg ttatcacact tggggtaact gatataactg     3480

tttgctgctt ccaattcctt acccattaaa ggggactggg aatgaagcta gaaccgggtg     3540

aggaattggt tagaaccagg aagttgtgct ctatcgccac ctgctgttca ctgtctagcg     3600

gtaccaccag ctgcccacag ttgcaaagaa ctggaattcc ctgatgcttt gggttcatct     3660

ggcaaacccg catttggact atgtgattga atgcacatta acaagcaagc aggtaaacac     3720

ttgcaacagt ggggtacagt tgggatcccc tgcctgtctt gctcattgcc acatcccggg     3780

tcccagctgt tgtgtacttg ctgggtggat tgagaagcta gcccctgaag atcatgagaa     3840

ccagggagaa c                                                          3851


<210>  5
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the nucleotide 39332332-39333399 of NCBI accession number 
       NC_000003.12

<400>  5
atggattata cacttgacct cagtgtgaca acagtgaccg actactacta ccctgatatc       60

ttctcaagcc cctgtgatgc ggaacttatt cagacaaatg gcaagttgct ccttgctgtc      120

ttttattgcc tcctgtttgt attcagtctt ctgggaaaca gcctggtcat cctggtcctt      180

gtggtctgca agaagctgag gagcatcaca gatgtatacc tcttgaacct ggccctgtct      240

gacctgcttt ttgtcttctc cttccccttt cagacctact atctgctgga ccagtgggtg      300

tttgggactg taatgtgcaa agtggtgtct ggcttttatt acattggctt ctacagcagc      360

atgtttttca tcaccctcat gagtgtggac aggtacctgg ctgttgtcca tgccgtgtat      420

gccctaaagg tgaggacgat caggatgggc acaacgctgt gcctggcagt atggctaacc      480

gccattatgg ctaccatccc attgctagtg ttttaccaag tggcctctga agatggtgtt      540

ctacagtgtt attcatttta caatcaacag actttgaagt ggaagatctt caccaacttc      600

aaaatgaaca ttttaggctt gttgatccca ttcaccatct ttatgttctg ctacattaaa      660

atcctgcacc agctgaagag gtgtcaaaac cacaacaaga ccaaggccat caggttggtg      720

ctcattgtgg tcattgcatc tttacttttc tgggtcccat tcaacgtggt tcttttcctc      780

acttccttgc acagtatgca catcttggat ggatgtagca taagccaaca gctgacttat      840

gccacccatg tcacagaaat catttccttt actcactgct gtgtgaaccc tgttatctat      900

gcttttgttg gggagaagtt caagaaacac ctctcagaaa tatttcagaa aagttgcagc      960

caaatcttca actacctagg aagacaaatg cctagggaga gctgtgaaaa gtcatcatcc     1020

tgccagcagc actcctcccg ttcctccagc gtagactaca ttttgtga                  1068


<210>  6
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the human CCR8 sequence upstream of the A 
       fragment and the mouse CCR8 gene

<400>  6
acctctcacg tgcctgcttg accaggtctt cctgcctcga tggattatac acttgacctc       60

agtgtgacaa cagtgaccga                                                   80


<210>  7
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the downstream of the human CCR8 sequence and 
       the mouse CCR8 gene

<400>  7
ctcctcccgt tcctccagcg tagactacat tttgtgaggg gagtgtgcag ggcaggcaga       60

ctccacctgc attgcccttc c                                                 81


<210>  8
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the mouse 
       gene

<400>  8
agatggctct gcagctaaag gcacttgttc ttactaagct tgatatcgaa ttccgaagtt       60

cctattctct agaaagtata ggaacttc                                          88


<210>  9
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the Neo cassette and the mouse 
       gene

<400>  9
gaagttccta ttctctagaa agtataggaa cttcatcagt caggtacata attaggtgga       60

tccactagtt ctagactgag aactggaccc aggggctgga gagatggctc agt             113


<210>  10
<211>  1162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the humanized mouse CCR8

<400>  10
tggcagagga gtgggcagct ctgaaacctc agaagaaagg ctcgctcaga taattggtct       60

tcctgcctcg atggattata cacttgacct cagtgtgaca acagtgaccg actactacta      120

ccctgatatc ttctcaagcc cctgtgatgc ggaacttatt cagacaaatg gcaagttgct      180

ccttgctgtc ttttattgcc tcctgtttgt attcagtctt ctgggaaaca gcctggtcat      240

cctggtcctt gtggtctgca agaagctgag gagcatcaca gatgtatacc tcttgaacct      300

ggccctgtct gacctgcttt ttgtcttctc cttccccttt cagacctact atctgctgga      360

ccagtgggtg tttgggactg taatgtgcaa agtggtgtct ggcttttatt acattggctt      420

ctacagcagc atgtttttca tcaccctcat gagtgtggac aggtacctgg ctgttgtcca      480

tgccgtgtat gccctaaagg tgaggacgat caggatgggc acaacgctgt gcctggcagt      540

atggctaacc gccattatgg ctaccatccc attgctagtg ttttaccaag tggcctctga      600

agatggtgtt ctacagtgtt attcatttta caatcaacag actttgaagt ggaagatctt      660

caccaacttc aaaatgaaca ttttaggctt gttgatccca ttcaccatct ttatgttctg      720

ctacattaaa atcctgcacc agctgaagag gtgtcaaaac cacaacaaga ccaaggccat      780

caggttggtg ctcattgtgg tcattgcatc tttacttttc tgggtcccat tcaacgtggt      840

tcttttcctc acttccttgc acagtatgca catcttggat ggatgtagca taagccaaca      900

gctgacttat gccacccatg tcacagaaat catttccttt actcactgct gtgtgaaccc      960

tgttatctat gcttttgttg gggagaagtt caagaaacac ctctcagaaa tatttcagaa     1020

aagttgcagc caaatcttca actacctagg aagacaaatg cctagggaga gctgtgaaaa     1080

gtcatcatcc tgccagcagc actcctcccg ttcctccagc gtagactaca ttttgtgagg     1140

ggagtgtgca gggcaggcag ac                                              1162


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
tgctagtgga agacagactt ccag                                              24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
cagcaaggag caacttgcca tttg                                              24


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gctcgactag agcttgcgga                                                   20


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
ctcacgagcc atctgaaacc ctgtt                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ctgctctcac accatcctga ctgag                                             25


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
tctcactgaa cttagagcca tctgtga                                           27


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ctcagccagt cacccatttc aaaaagc                                           27


<210>  18
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
gtctccaccg tgtcctctac atcctg                                            26


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
ggatcggcca ttgaacaaga t                                                 21


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
cagaagaact cgtcaagaag gc                                                22


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
acactaacac cctgacattg agccg                                             25


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gatggtggct gtgacagcag cc                                                22


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
cagcaaggag caacttgcca tttg                                              24


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
tcagcctcct gaacgctgga cca                                               23


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
tagctatctt cagacgcacc ag                                                22


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
gacaagcgtt agtaggcaca tatac                                             25


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
gctccaattt cccacaacat tagt                                              24


<210>  28
<211>  1484
<212>  DNA
<213>  Homo sapiens

<400>  28
gtagtgggag gatacctcca gagaggctgc tgctcattga gctgcactca catgaggata       60

cagactttgt gaagaaggaa ttggcaacac tgaaacctcc agaacaaagg ctgtcactaa      120

ggtcccgctg ccttgatgga ttatacactt gacctcagtg tgacaacagt gaccgactac      180

tactaccctg atatcttctc aagcccctgt gatgcggaac ttattcagac aaatggcaag      240

ttgctccttg ctgtctttta ttgcctcctg tttgtattca gtcttctggg aaacagcctg      300

gtcatcctgg tccttgtggt ctgcaagaag ctgaggagca tcacagatgt atacctcttg      360

aacctggccc tgtctgacct gctttttgtc ttctccttcc cctttcagac ctactatctg      420

ctggaccagt gggtgtttgg gactgtaatg tgcaaagtgg tgtctggctt ttattacatt      480

ggcttctaca gcagcatgtt tttcatcacc ctcatgagtg tggacaggta cctggctgtt      540

gtccatgccg tgtatgccct aaaggtgagg acgatcagga tgggcacaac gctgtgcctg      600

gcagtatggc taaccgccat tatggctacc atcccattgc tagtgtttta ccaagtggcc      660

tctgaagatg gtgttctaca gtgttattca ttttacaatc aacagacttt gaagtggaag      720

atcttcacca acttcaaaat gaacatttta ggcttgttga tcccattcac catctttatg      780

ttctgctaca ttaaaatcct gcaccagctg aagaggtgtc aaaaccacaa caagaccaag      840

gccatcaggt tggtgctcat tgtggtcatt gcatctttac ttttctgggt cccattcaac      900

gtggttcttt tcctcacttc cttgcacagt atgcacatct tggatggatg tagcataagc      960

caacagctga cttatgccac ccatgtcaca gaaatcattt cctttactca ctgctgtgtg     1020

aaccctgtta tctatgcttt tgttggggag aagttcaaga aacacctctc agaaatattt     1080

cagaaaagtt gcagccaaat cttcaactac ctaggaagac aaatgcctag ggagagctgt     1140

gaaaagtcat catcctgcca gcagcactcc tcccgttcct ccagcgtaga ctacattttg     1200

tgaggatcaa tgaagactaa atataaaaaa cattttcttg aatggcatgc tagtagcagt     1260

gagcaaaggt gtgggtgtga aaggtttcca aaaaaagttc agcatgaagg atgccatata     1320

tgttgttgcc aacacttgga acacaatgac taaagacata gttgtgcatg cctggcacaa     1380

catcaagcct gtgattgtgt ttattgatga tgttgaacaa gtggtaactt taaaggattc     1440

tgtatgccaa gtgaaaaaaa aagatgtctg acctccttac atat                      1484


<210>  29
<211>  1156
<212>  DNA
<213>  Mus musculus

<400>  29
tggcagagga gtgggcagct ctgaaacctc agaagaaagg ctcgctcaga taattggtct       60

tcctgcctcg atggattaca cgatggagcc caacgtcacg atgaccgact actaccctga      120

tttcttcacc gccccctgtg acgcagagtt cctcctcagg ggcagcatgc tgtatctggc      180

catcttgtac tgcgtcttgt ttgtgctggg ccttctgggg aacagcctgg tcatcttagt      240

cctcgtgggc tgcaagaaac tgaggagcat cacagatatc tacctcctga acctggccgc      300

atccgacctg ctctttgtcc tctctattcc ttttcagacc cacaacctgc tggaccagtg      360

ggtgtttggg actgcgatgt gtaaggtggt ctctggcctt tattacattg gttttttcag      420

cagtatgttc ttcatcaccc taatgagtgt ggacaggtat ctggctattg tccacgctgt      480

ctatgccatc aaggtgagga cggccagcgt gggcacagcc ctgagtctga cagtgtggct      540

ggctgctgtc acagccacca tccccttgat ggttttttac caagtggcct ctgaagacgg      600

catgctacaa tgtttccagt tttatgaaga gcagtctttg aggtggaagc tctttaccca      660

ctttgaaatc aacgccttgg gtctgctgct cccctttgcc atcctcctgt tctgctatgt      720

caggatcctg cagcagctgc ggggctgcct gaaccacaac aggaccagag ccatcaagct      780

ggtgctcacc gtagtcattg tgtctttact cttctgggtc ccattcaacg tggccctttt      840

cctcacgtcc ctgcacgacc tgcacatctt ggatggatgt gccacgaggc agaggctggc      900

tctggccatc catgtcacag aggtcatctc ttttacccac tgctgcgtga accccgtcat      960

ctacgcgttc ataggagaga agtttaagaa acacctcatg gatgtgtttc aaaagagctg     1020

cagccacatc ttcctctact tagggagaca aatgcccgtg ggggcgttgg aaaggcagct     1080

gtcctcgaac cagcgatctt cccattcttc caccctggat gacatcttgt aaggggagtg     1140

tgcagggcag gcagac                                                     1156


