                         SEQUENCE LISTING

<110>  The University of British Columbia
 
<120>  VACCINE FOR VIRAL PATHOGENS

<130>  338-129PCT

<150>  US 63/077,107
<151>  2020-09-11

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein published under GenBank Accession YP_009724390

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein 

<400>  2

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Lys Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Leu Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1130                 1135                 1140             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1145                 1150                 1155             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1160                 1165                 1170             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1175                 1180                 1185             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp 
    1190                 1195                 1200             


Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile Val Met  Val Thr Ile 
    1205                 1210                 1215             


Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys 
    1220                 1225                 1230             


Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu 
    1235                 1240                 1245             


Pro Val  Leu Lys Gly Val Lys  Leu His Tyr Thr 
    1250                 1255                 


<210>  3
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein 

<400>  3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    1265                 1270                 1275             


Arg Leu  Thr Glu 
    1280         


<210>  4
<211>  1280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein 

<400>  4

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Ser Val Ala Ser Gln Ser Ile Ile Ala 
        675                 680                 685             


Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn 
    690                 695                 700                 


Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr Thr Glu Ile 
705                 710                 715                 720 


Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile 
                725                 730                 735     


Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser 
            740                 745                 750         


Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln 
        755                 760                 765             


Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys 
    770                 775                 780                 


Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu 
785                 790                 795                 800 


Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu 
                805                 810                 815     


Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly 
            820                 825                 830         


Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        835                 840                 845             


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile 
    850                 855                 860                 


Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp 
865                 870                 875                 880 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                885                 890                 895     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            900                 905                 910         


Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile 
        915                 920                 925             


Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp 
    930                 935                 940                 


Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu 
945                 950                 955                 960 


Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ala 
                965                 970                 975     


Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr 
            980                 985                 990         


Gly Arg Leu Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
        995                 1000                 1005             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1010                 1015                 1020             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1025                 1030                 1035             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1040                 1045                 1050             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1055                 1060                 1065             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1070                 1075                 1080             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1085                 1090                 1095             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr His Asn 
    1100                 1105                 1110             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1115                 1120                 1125             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1130                 1135                 1140             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1145                 1150                 1155             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1160                 1165                 1170             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1175                 1180                 1185             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1190                 1195                 1200             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1205                 1210                 1215             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1220                 1225                 1230             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1235                 1240                 1245             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1250                 1255                 1260             


Leu His  Tyr Thr Ser Arg Leu  Glu Glu Glu Leu Arg  Arg Arg Leu 
    1265                 1270                 1275             


Thr Glu  
    1280 


<210>  5
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein 

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    1265                 1270                 1275             


Arg Leu  Thr Glu 
    1280         


<210>  6
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ile Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
65                  70                  75                  80  


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
                85                  90                  95      


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
            100                 105                 110         


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
        115                 120                 125             


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
    130                 135                 140                 


His Lys Asn Asn Lys Ser Cys Met Glu Ser Glu Phe Arg Val Tyr Ser 
145                 150                 155                 160 


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
                165                 170                 175     


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
            180                 185                 190         


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
        195                 200                 205             


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
    210                 215                 220                 


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
225                 230                 235                 240 


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
                245                 250                 255     


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
            260                 265                 270         


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
        275                 280                 285             


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
    290                 295                 300                 


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
305                 310                 315                 320 


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
                325                 330                 335     


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
            340                 345                 350         


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
        355                 360                 365             


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
    370                 375                 380                 


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
385                 390                 395                 400 


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
                405                 410                 415     


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
            420                 425                 430         


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
        435                 440                 445             


Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
    450                 455                 460                 


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
465                 470                 475                 480 


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
                485                 490                 495     


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
            500                 505                 510         


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
        515                 520                 525             


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
    530                 535                 540                 


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
545                 550                 555                 560 


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
                565                 570                 575     


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
            580                 585                 590         


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
        595                 600                 605             


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
    610                 615                 620                 


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
625                 630                 635                 640 


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
                645                 650                 655     


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            660                 665                 670         


Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile Ile 
        675                 680                 685             


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn 
    690                 695                 700                 


Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu 
705                 710                 715                 720 


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr 
                725                 730                 735     


Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly 
            740                 745                 750         


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu 
        755                 760                 765             


Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr 
    770                 775                 780                 


Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile 
785                 790                 795                 800 


Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu 
                805                 810                 815     


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
            820                 825                 830         


Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln 
        835                 840                 845             


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met 
    850                 855                 860                 


Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly 
865                 870                 875                 880 


Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln 
                885                 890                 895     


Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
            900                 905                 910         


Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys 
        915                 920                 925             


Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln 
    930                 935                 940                 


Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln 
945                 950                 955                 960 


Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu 
                965                 970                 975     


Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile 
            980                 985                 990         


Thr Gly Arg Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
        995                 1000                 1005             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1010                 1015                 1020             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1025                 1030                 1035             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1040                 1045                 1050             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1055                 1060                 1065             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1070                 1075                 1080             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1085                 1090                 1095             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1100                 1105                 1110             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1115                 1120                 1125             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1130                 1135                 1140             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1145                 1150                 1155             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1160                 1165                 1170             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1175                 1180                 1185             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1190                 1195                 1200             


Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu Gly Phe  Ile Ala Gly 
    1205                 1210                 1215             


Leu Ile  Ala Ile Val Met Val  Thr Ile Met Leu Cys  Cys Met Thr 
    1220                 1225                 1230             


Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys Ser Cys  Gly Ser Cys 
    1235                 1240                 1245             


Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro Val Leu  Lys Gly Val 
    1250                 1255                 1260             


Lys Leu  His Tyr Thr Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg 
    1265                 1270                 1275             


Leu Thr  Glu 
    1280     


<210>  7
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein

<400>  7

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Ile 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Phe Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    1265                 1270                 1275             


Arg Leu  Thr Glu 
    1280         


<210>  8
<211>  1281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein

<400>  8

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Lys Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Gln Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Ser Val Ala Ser Gln Ser Ile Ile 
        675                 680                 685             


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn 
    690                 695                 700                 


Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr Thr Glu 
705                 710                 715                 720 


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr 
                725                 730                 735     


Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly 
            740                 745                 750         


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu 
        755                 760                 765             


Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr 
    770                 775                 780                 


Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile 
785                 790                 795                 800 


Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu 
                805                 810                 815     


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
            820                 825                 830         


Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln 
        835                 840                 845             


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met 
    850                 855                 860                 


Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly 
865                 870                 875                 880 


Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln 
                885                 890                 895     


Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
            900                 905                 910         


Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys 
        915                 920                 925             


Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln 
    930                 935                 940                 


Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln 
945                 950                 955                 960 


Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu 
                965                 970                 975     


Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile 
            980                 985                 990         


Thr Gly Arg Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
        995                 1000                 1005             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1010                 1015                 1020             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1025                 1030                 1035             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1040                 1045                 1050             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  His Glu Lys 
    1055                 1060                 1065             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1070                 1075                 1080             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1085                 1090                 1095             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr His 
    1100                 1105                 1110             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1115                 1120                 1125             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1130                 1135                 1140             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1145                 1150                 1155             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1160                 1165                 1170             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1175                 1180                 1185             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1190                 1195                 1200             


Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu Gly Phe  Ile Ala Gly 
    1205                 1210                 1215             


Leu Ile  Ala Ile Val Met Val  Thr Ile Met Leu Cys  Cys Met Thr 
    1220                 1225                 1230             


Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys Ser Cys  Gly Ser Cys 
    1235                 1240                 1245             


Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro Val Leu  Lys Gly Val 
    1250                 1255                 1260             


Lys Leu  His Tyr Thr Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg 
    1265                 1270                 1275             


Leu Thr  Glu 
    1280     


<210>  9
<211>  1252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike proteins where the furin cleavage site is absent

<400>  9

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Lys Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Leu Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Ala Ser Gln Ser Ile Ile 
            660                 665                 670         


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn 
        675                 680                 685             


Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu 
    690                 695                 700                 


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr 
705                 710                 715                 720 


Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly 
                725                 730                 735     


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu 
            740                 745                 750         


Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr 
        755                 760                 765             


Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile 
    770                 775                 780                 


Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu 
785                 790                 795                 800 


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
                805                 810                 815     


Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln 
            820                 825                 830         


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met 
        835                 840                 845             


Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly 
    850                 855                 860                 


Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln 
865                 870                 875                 880 


Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
                885                 890                 895     


Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys 
            900                 905                 910         


Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln 
        915                 920                 925             


Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln 
    930                 935                 940                 


Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu 
945                 950                 955                 960 


Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile 
                965                 970                 975     


Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile 
            980                 985                 990         


Arg Ala Ala Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
        995                 1000                 1005             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1010                 1015                 1020             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1025                 1030                 1035             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1040                 1045                 1050             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1055                 1060                 1065             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1070                 1075                 1080             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1085                 1090                 1095             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1100                 1105                 1110             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1115                 1120                 1125             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1130                 1135                 1140             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1145                 1150                 1155             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1160                 1165                 1170             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1175                 1180                 1185             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1190                 1195                 1200             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1205                 1210                 1215             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1220                 1225                 1230             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1235                 1240                 1245             


Leu His  Tyr Thr 
    1250         


<210>  10
<211>  1199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike proteins where the furin cleavage site is absent

<400>  10

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Lys Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Leu Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1130                 1135                 1140             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1145                 1150                 1155             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1160                 1165                 1170             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1175                 1180                 1185             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro 
    1190                 1195                 


<210>  11
<211>  1199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  11

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1130                 1135                 1140             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1145                 1150                 1155             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1160                 1165                 1170             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1175                 1180                 1185             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro 
    1190                 1195                 


<210>  12
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  12

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln 
            660                 665                 670         


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
        675                 680                 685             


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
    690                 695                 700                 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
            740                 745                 750         


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
                805                 810                 815     


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
    850                 855                 860                 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
            900                 905                 910         


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1040                 1045                 1050             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1055                 1060                 1065             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1070                 1075                 1080             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Ser Arg Leu Glu Glu  Glu Leu Arg 
    1190                 1195                 1200             


Arg Arg  Leu Thr Glu 
    1205             


<210>  13
<211>  1206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  13

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
    50                  55                  60                  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
65                  70                  75                  80  


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
                85                  90                  95      


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
            100                 105                 110         


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
        115                 120                 125             


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
    130                 135                 140                 


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
145                 150                 155                 160 


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
                165                 170                 175     


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
            180                 185                 190         


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
        195                 200                 205             


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
    210                 215                 220                 


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
225                 230                 235                 240 


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
                245                 250                 255     


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
            260                 265                 270         


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
        275                 280                 285             


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
    290                 295                 300                 


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
305                 310                 315                 320 


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
                325                 330                 335     


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
            340                 345                 350         


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
        355                 360                 365             


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
    370                 375                 380                 


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
385                 390                 395                 400 


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
                405                 410                 415     


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
            420                 425                 430         


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
        435                 440                 445             


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
    450                 455                 460                 


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
465                 470                 475                 480 


Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
                485                 490                 495     


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
            500                 505                 510         


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
        515                 520                 525             


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
    530                 535                 540                 


Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg 
545                 550                 555                 560 


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
                565                 570                 575     


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
            580                 585                 590         


Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
        595                 600                 605             


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
    610                 615                 620                 


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
625                 630                 635                 640 


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
                645                 650                 655     


Tyr Gln Thr Gln Thr Asn Ser His Arg Ser Val Ala Ser Gln Ser Ile 
            660                 665                 670         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
        675                 680                 685             


Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr Thr 
    690                 695                 700                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
705                 710                 715                 720 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                725                 730                 735     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            740                 745                 750         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        755                 760                 765             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    770                 775                 780                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
785                 790                 795                 800 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                805                 810                 815     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            820                 825                 830         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        835                 840                 845             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
    850                 855                 860                 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
865                 870                 875                 880 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                885                 890                 895     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            900                 905                 910         


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
        915                 920                 925             


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
    930                 935                 940                 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
945                 950                 955                 960 


Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
                965                 970                 975     


Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
            980                 985                 990         


Ile Arg Ala Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
        995                 1000                 1005             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1010                 1015                 1020             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1025                 1030                 1035             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1055                 1060                 1065             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1070                 1075                 1080             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr His 
    1085                 1090                 1095             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1100                 1105                 1110             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1115                 1120                 1125             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1130                 1135                 1140             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1145                 1150                 1155             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1160                 1165                 1170             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1175                 1180                 1185             


Tyr Ile  Lys Trp Pro Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg 
    1190                 1195                 1200             


Leu Thr  Glu 
    1205     


<210>  14
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  14

Met Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln 
            660                 665                 670         


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala 
        675                 680                 685             


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
    690                 695                 700                 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
            740                 745                 750         


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
                805                 810                 815     


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
    850                 855                 860                 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
            900                 905                 910         


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1040                 1045                 1050             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1055                 1060                 1065             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1070                 1075                 1080             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Ser Arg Leu Glu Glu  Glu Leu Arg 
    1190                 1195                 1200             


Arg Arg  Leu Thr Glu 
    1205             


<210>  15
<211>  1207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  15

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Cys Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser 
            660                 665                 670         


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
        675                 680                 685             


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
    690                 695                 700                 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
705                 710                 715                 720 


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
                725                 730                 735     


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
            740                 745                 750         


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
        755                 760                 765             


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
    770                 775                 780                 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
785                 790                 795                 800 


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
                805                 810                 815     


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
            820                 825                 830         


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
        835                 840                 845             


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
    850                 855                 860                 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
865                 870                 875                 880 


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
                885                 890                 895     


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
            900                 905                 910         


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
        915                 920                 925             


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
    930                 935                 940                 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
945                 950                 955                 960 


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
                965                 970                 975     


Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 
            980                 985                 990         


Leu Ile Arg Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
        995                 1000                 1005             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1010                 1015                 1020             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1025                 1030                 1035             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1040                 1045                 1050             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1055                 1060                 1065             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1070                 1075                 1080             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1085                 1090                 1095             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1100                 1105                 1110             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1115                 1120                 1125             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1130                 1135                 1140             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1145                 1150                 1155             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1160                 1165                 1170             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1175                 1180                 1185             


Gln Tyr  Ile Lys Trp Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    1190                 1195                 1200             


Arg Leu  Thr Glu 
    1205         


<210>  16
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  16

Met Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln 
            660                 665                 670         


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
        675                 680                 685             


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
    690                 695                 700                 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
            740                 745                 750         


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
                805                 810                 815     


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
    850                 855                 860                 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
            900                 905                 910         


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Ile Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1040                 1045                 1050             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1055                 1060                 1065             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1070                 1075                 1080             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Phe 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Ser Arg Leu Glu Glu  Glu Leu Arg 
    1190                 1195                 1200             


Arg Arg  Leu Thr Glu 
    1205             


<210>  17
<211>  1207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  17

Met Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Ile Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Lys Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
225                 230                 235                 240 


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
                245                 250                 255     


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
            260                 265                 270         


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
        275                 280                 285             


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
    290                 295                 300                 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
305                 310                 315                 320 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
            340                 345                 350         


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
        355                 360                 365             


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
    370                 375                 380                 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
385                 390                 395                 400 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
                405                 410                 415     


Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Gly 
            420                 425                 430         


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
    450                 455                 460                 


Pro Cys Asn Gly Val Gln Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
465                 470                 475                 480 


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Ser Val Ala Ser Gln Ser 
            660                 665                 670         


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
        675                 680                 685             


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
    690                 695                 700                 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
705                 710                 715                 720 


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
                725                 730                 735     


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
            740                 745                 750         


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
        755                 760                 765             


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
    770                 775                 780                 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
785                 790                 795                 800 


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
                805                 810                 815     


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
            820                 825                 830         


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
        835                 840                 845             


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
    850                 855                 860                 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
865                 870                 875                 880 


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
                885                 890                 895     


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
            900                 905                 910         


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
        915                 920                 925             


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
    930                 935                 940                 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
945                 950                 955                 960 


Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
                965                 970                 975     


Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 
            980                 985                 990         


Leu Ile Arg Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
        995                 1000                 1005             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1010                 1015                 1020             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1025                 1030                 1035             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala His Glu 
    1040                 1045                 1050             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1055                 1060                 1065             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1070                 1075                 1080             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1085                 1090                 1095             


His Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1100                 1105                 1110             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1115                 1120                 1125             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1130                 1135                 1140             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1145                 1150                 1155             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1160                 1165                 1170             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1175                 1180                 1185             


Gln Tyr  Ile Lys Trp Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    1190                 1195                 1200             


Arg Leu  Thr Glu 
    1205         


<210>  18
<211>  3855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding a spike protein

<400>  18
gccaccatgt tcgtatttct cgtcctcctc ccacttgttt ctagtcagtg tgtgaacctc       60

actacgcgaa ctcaactgcc gcctgcttac actaatagtt ttacacgagg agtctactac      120

ccggacaagg tgttccgctc aagtgtcttg cacagcacgc aagacctgtt cttgccattt      180

ttcagcaatg taacgtggtt tcatgccatc cacgtgtcag gtactaacgg aacgaagaga      240

tttgataacc cggtcctccc gttcaacgac ggggtttatt ttgccagtac agaaaagtcc      300

aatattataa ggggatggat tttcggcacg actctcgact ctaagacaca aagcttgctc      360

atcgttaata atgctacaaa cgtggttata aaagtatgcg agttccaatt ctgtaacgac      420

ccctttctgg gggtttacta ccacaaaaat aataagagtt ggatggagag cgaattcaga      480

gtttactctt ccgcgaataa ttgcaccttc gagtacgtat cccagccttt tcttatggat      540

cttgagggga aacaaggtaa tttcaaaaac cttagagaat tcgtttttaa gaatatagat      600

ggatacttca agatttattc taaacatacc ccaatcaatc tggtgcgcga tcttcctcag      660

ggtttctctg cgctggagcc tctcgttgat ctgccgatcg gaattaatat aaccagattc      720

cagacccttt tggcattgca ccgctcctat ctgacacctg gggatagtag ttccggctgg      780

acagcgggcg ccgcggcata ctacgttgga tatctccaac cccgcacttt tcttctgaaa      840

tataatgaga atggaacgat tacagacgca gtagattgcg cgcttgaccc cctttcagaa      900

acaaagtgca cgctgaaatc tttcacggtc gagaagggca tttaccaaac gtccaatttc      960

agagttcaac ccactgagtc tatagtcagg tttccgaaca tcaccaatct ctgcccattt     1020

ggagaggttt tcaacgcaac acggttcgcc tctgtatacg catggaatag aaagagaata     1080

tccaattgtg tcgcagacta tagtgtcttg tacaactctg cgtcatttag cacttttaaa     1140

tgttatgggg tgagtccaac taaattgaac gatctctgct ttacaaatgt ttacgcagat     1200

agttttgtga tacgaggcga cgaggtacga caaattgctc ctggccagac cgggaaaata     1260

gcggactaca attataaact gccagacgat ttcaccggct gtgtgatcgc gtggaactca     1320

aacaacttgg atagtaaggt aggtggtaac tataactact tgtaccggct cttccgcaaa     1380

agtaatctta aaccgttcga gcgggacatc tctaccgaga tctatcaagc aggtagcact     1440

ccctgcaatg gagtcgaggg ttttaattgc tattttcccc tccaatcata cgggtttcag     1500

cccacaaatg gtgttgggta tcagccctat cgagttgtgg tgctttcatt tgaattgctt     1560

catgcaccgg cgacagtttg tggtcctaaa aagagtacca atttggttaa aaacaaatgt     1620

gtcaacttta actttaacgg tctgactggt acgggggtgc ttacggaatc taataaaaag     1680

tttcttccgt tccagcaatt cggacgggac atagcggaca cgactgacgc ggttagagac     1740

ccacaaacac tcgagattct tgacataacc ccctgttctt tcggcggagt ttctgtaata     1800

acgcctggga caaatacgtc aaaccaggtt gcagtattgt accaggatgt caactgcact     1860

gaagtgccag tcgcgatcca cgcagatcag ttgactccaa catggagggt ctactctacc     1920

ggttctaacg tgtttcagac cagagccggg tgcctcattg gcgcggaaca tgtgaacaat     1980

tcttacgaat gcgacatacc catcggcgcc ggcatttgtg cgtcatacca aactcaaact     2040

aattcccgga gtgtggcctc ccaatctatt attgcttata ctatgagtct tggcgcggaa     2100

aacagtgtag cgtactcaaa taactctatt gcgatcccca cgaatttcac tataagcgta     2160

actactgaaa ttttgccggt aagcatgacg aaaacttcag tggactgcac aatgtacatt     2220

tgtggtgaca gcactgagtg ctcaaatctc ctccttcagt atggttcttt ctgcacacaa     2280

cttaacaggg cacttaccgg aatcgcagta gaacaagaca aaaacacgca agaagtattc     2340

gcacaggtca aacaaattta taaaaccccg ccgatcaagg attttggagg gtttaacttc     2400

agtcagatcc ttccagaccc atccaaaccc agcaaacgga gctttattga agacctgctg     2460

tttaataaag ttacccttgc agatgccggt ttcatcaagc aatacgggga ttgtctgggc     2520

gacattgccg cccgcgactt gatctgtgcc cagaagttca acggtctcac agtcttgccg     2580

ccacttctca ctgatgaaat gatagcgcag tatacatccg cgctgctggc tgggacgata     2640

acatctggtt ggactttcgg ggccggggcg gctttgcaaa ttcctttcgc catgcagatg     2700

gcctataggt ttaacggcat aggagtgact caaaatgttc tttatgagaa tcagaagctt     2760

atcgccaacc aatttaactc cgcgattggg aagatacagg actcattgag ctctactgct     2820

agcgcccttg gcaagcttca agacgtagtc aaccaaaatg ctcaagcgct caatactctc     2880

gtaaagcagc tctcaagcaa ctttggcgcg atatcttcag ttttgaacga catcttgagc     2940

agactcgaca aggtggaggc tgaagttcaa attgatcgac tgattacggg ccggctccag     3000

tcactccaaa cgtacgtgac ccaacaactc attagagcgg cagagattag agcgagcgct     3060

aatctggcgg ccacaaagat gtcagaatgt gtgcttggtc aatccaaaag ggtggatttc     3120

tgcggaaagg gctatcactt gatgagtttc ccgcagtccg cgcctcatgg agttgttttc     3180

ctccacgtaa cctacgttcc cgctcaggaa aagaatttca cgacagctcc ggcaatatgt     3240

catgacggta aagcacattt ccccagggaa ggcgtttttg tcagtaatgg aacccactgg     3300

ttcgtcaccc agcgaaactt ttacgagccc caaataataa ctactgacaa taccttcgtc     3360

agcggcaatt gcgacgtcgt cataggcata gtaaataata cggtttacga ccctcttcaa     3420

cccgagttgg acagcttcaa agaagaactt gataagtatt ttaaaaacca cactagccca     3480

gatgtagacc ttggcgacat cagcggtatc aatgcttccg ttgtgaacat tcaaaaggaa     3540

attgaccgac tcaatgaagt agcgaagaac ttgaatgagt ctctgatcga tcttcaggag     3600

ctcgggaaat atgagcaata catcaaatgg ccgtggtaca tctggctggg ttttatagct     3660

ggcctgatcg caattgtaat ggtaactata atgttgtgtt gcatgacctc ttgctgcagc     3720

tgtttgaagg gatgctgttc ttgcgggagt tgctgtaaat ttgatgagga tgacagcgag     3780

ccggtgttga aaggagtgaa gcttcattat acttcacgac tggaggaaga actgcgccga     3840

cgcctgactg aatga                                                      3855


<210>  19
<211>  3849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  19
gccaccatgt tcgtctttct cgtgctgttg cctcttgtat cttctcagtg cgttaacctg       60

acaacacgca cccagttgcc accggcctat acgaactctt tcacgcgcgg agtgtattat      120

cccgataaag tctttcggag ttctgtgctg cactctacac aagatctttt tctgcccttt      180

ttctccaacg ttacgtggtt ccatgcaata agtggtacga atggtactaa aaggttcgat      240

aatcccgtac ttcccttcaa tgacggcgtg tatttcgcga gcacagaaaa gagcaacata      300

ataagaggtt ggatttttgg gactaccctg gactctaaaa cacaaagcct cctcattgtt      360

aataacgcaa ctaatgtcgt aataaaggta tgcgaatttc agttttgtaa cgaccctttt      420

ttgggagtct atcataagaa caataagtcc tggatggaaa gtgaatttag ggtgtatagt      480

tcagcgaaca actgtacatt tgagtatgtg tcacagccgt tccttatgga tcttgaaggg      540

aaacagggga acttcaagaa cctgcgggaa ttcgtgttta aaaatataga cggttatttt      600

aaaatctata gcaaacacac cccaataaac ctggttcggg atcttcctca gggattttca      660

gctttggaac cgttggttga cctccccatc gggataaata tcacgcgatt tcaaacactg      720

ctggcactgc accggagtta tctgactcct ggagatagca gctccggctg gacggctggc      780

gccgcggctt attatgtcgg gtaccttcaa ccgcgaacgt ttcttttgaa gtataacgaa      840

aatggcacta taaccgatgc agtagattgt gcgttggacc ctctttccga gactaagtgc      900

accctgaagt catttacagt agagaagggg atataccaga caagcaactt ccgcgtccaa      960

ccaacggaaa gcatcgtgcg ctttcccaat attactaacc tctgtccgtt cggcgaggtt     1020

tttaatgcta ccagatttgc ctcagtgtat gcctggaacc gcaagaggat tagcaactgc     1080

gttgctgact atagcgtgct ttacaattcc gccagtttta gtacgttcaa gtgttatggg     1140

gtaagcccta ccaagcttaa cgatctttgc ttcacgaatg tttacgcaga ctcattcgta     1200

atacgaggtg atgaagtgcg acagatagcc ccgggtcaga cggggaaaat agccgactac     1260

aattacaagc tcccggacga cttcacgggc tgtgttattg cgtggaacag caataacctg     1320

gacagtaaag ttggagggaa ttataactac ttgtacaggc tgttccgcaa atctaatttg     1380

aaaccgtttg aaagggacat ttccaccgag atttaccaag ccggcagtac cccatgtaac     1440

ggagttgagg gatttaattg ctactttccg ctccaatcat atggattcca gcctacatac     1500

ggcgtcggat atcaacctta tagggtggtc gttctttctt ttgagctgct tcacgcccca     1560

gcaaccgttt gcggcccgaa aaaatcaacg aacttggtca aaaacaagtg cgtcaacttc     1620

aatttcaacg gactgacagg caccggagtg ctcaccgagt caaataaaaa attcctcccg     1680

tttcaacaat tcggtagaga tatagacgac accacagatg cggtacgcga ccctcagact     1740

cttgaaattt tggacattac accatgttcc ttcggtggcg tctcagtgat tacgcctggc     1800

actaacacta gcaaccaagt cgcagtactt tatcagggcg ttaactgtac agaagtacca     1860

gttgcgatac acgcggacca gctcacccca acctggcgcg tatattctac cggatctaat     1920

gtgtttcaaa cgcgggcggg gtgcctcata ggtgcagagc atgtcaataa ctcctacgaa     1980

tgtgacattc ctataggagc aggaatatgt gcgagctacc agactcaaac caattcacac     2040

aggagcgtag ctagtcagtc cataattgcc tacactatgt cacttggtgc tgaaaacagt     2100

gtggcttatt caaataattc catagctatt ccaatcaatt tcactattag cgtaacaact     2160

gagatacttc cagtcagcat gactaagact tcagttgatt gtacgatgta tatttgtggc     2220

gattctacag aatgtagtaa ccttctgttg caatacggct ccttttgcac acagctcaat     2280

cgcgcattga cgggtatagc tgtagagcaa gataaaaaca cccaagaagt cttcgcgcag     2340

gtgaagcaaa tatataagac accaccgatt aaagatttcg gtggattcaa ttttagccaa     2400

attctgcctg atccaagcaa accgtcaaaa agatccttca tagaggacct gcttttcaat     2460

aaggtaacgc tggcggacgc agggtttatt aaacaatacg gcgattgcct tggtgacatt     2520

gctgcacgag acctcatttg cgcccagaag ttcaacggac tcacagtact gcctccactg     2580

ctcacagacg agatgatcgc ccagtacaca tctgccttgt tggctggtac gataacttct     2640

ggttggacct ttggagcggg agcagcactt cagattccct ttgccatgca gatggcgtac     2700

agattcaacg gcattggtgt cacgcagaac gtactgtatg agaaccagaa gttgatagct     2760

aatcaattca actccgcgat aggtaagatc caagacagtc tctcctcaac agcctccgca     2820

ctcgggaaac tccaggatgt ggtaaatcag aatgcacagg cattgaatac gcttgttaaa     2880

caattgtcct caaattttgg cgccatatca tcagtgctca acgacatcct tgccagactc     2940

gataaagtgg aggcagaagt gcagatagat cgcttgatta ctgggcgcct ccaatctctc     3000

caaacgtacg tgacacaaca gcttattcgg gcagcggaaa tccgcgcctc tgcgaacctt     3060

gcagcgacca agatgagcga atgtgttctc gggcagtcaa aacgagtaga tttctgcggt     3120

aaaggatatc atcttatgtc attcccccaa agcgctccac atggtgttgt atttctgcac     3180

gtgacttacg tgccggcaca ggagaagaat ttcacaacgg ctcccgccat ctgtcacgac     3240

ggaaaggcac acttccctag ggagggggtg tttgtaagca atggtaccca ctggtttgtc     3300

acacaacgaa acttctatga acctcagata attacaacgc ataatacttt tgtaagtggg     3360

aactgcgacg tcgttatcgg aatagttaac aatactgtat atgatccgtt gcagccggag     3420

ttggactcat ttaaagaaga gctggacaag tacttcaaaa accatacaag cccagatgta     3480

gatcttgggg acataagtgg gataaacgcc agcgttgtga acatacagaa ggaaatagac     3540

aggctgaatg aggtagcaaa gaatcttaac gaaagcctta tagatcttca ggaacttggg     3600

aagtacgaac agtacataaa gtggccttgg tatatttggc tcggtttcat cgctggactc     3660

atagcgatag taatggtgac tatcatgctg tgttgtatga ccagttgctg ctcatgcctg     3720

aagggttgct gctcttgcgg ctcctgctgt aaattcgacg aagatgactc cgagccagtg     3780

ctgaaggggg tgaagctgca ttatacttca cgactggagg aagaactgcg ccgacgcctg     3840

actgaatga                                                             3849


<210>  20
<211>  3855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  20
gccaccatgt tcgtattcct tgttcttttg ccgcttgtgt cttctcagtg tgtcaatttc       60

actacacgca cacagctgcc cccggcgtac actaacagtt ttacgagggg agtctactac      120

ccggacaaag tgttcaggtc ttccgtactc catagcacac aagacctctt cttgcctttt      180

ttcagcaatg ttacgtggtt ccatgcaatc catgtgagcg gtacaaacgg gactaaacgc      240

tttgcaaatc cagtgttgcc cttcaacgac ggtgtatact tcgcgagtac agagaagagc      300

aacataatac gcgggtggat atttggaacg acgcttgatt ctaagacaca gagcttgctc      360

atcgtaaaca acgcaacgaa tgttgtaatc aaggtctgcg aattccaatt ctgcaatgac      420

ccatttcttg gagtttatta ccataagaac aataagtctt ggatggaatc cgagttccgc      480

gtatactcta gcgcgaacaa ctgcaccttc gagtatgtgt cccaaccgtt tctgatggat      540

cttgagggaa agcagggtaa ttttaaaaat ctccgggagt tcgttttcaa aaatattgac      600

ggatatttca aaatctacag caagcatacc ccaatcaatt tggtgcgggg tctgccacaa      660

ggattttccg ctcttgaacc tcttgttgac cttcccatag gaatcaatat aactcggttc      720

caaactcttc ttgcgctcca tatatcctac ttgacgcccg gagattcatc aagtggctgg      780

acggctgggg ctgccgcata ctacgtcggc tatctgcaac caaggacgtt tctcctcaaa      840

tacaatgaaa atggtacgat caccgacgct gtggactgcg ctctcgaccc gttgtcagag      900

acgaagtgca ccttgaagtc cttcaccgtg gaaaagggaa tttaccagac tagtaacttc      960

cgggtgcagc ccacggaatc aattgtgcga tttcctaata tcactaatct ctgtcccttc     1020

ggggaagtgt tcaatgcgac tcgattcgct tcagtatacg cttggaatag aaagagaatc     1080

tcaaattgcg tggctgacta ttccgtactg tataatagtg cgtcttttag cacgtttaag     1140

tgttatggcg tatccccgac aaagctcaac gatctctgct tcacgaatgt ctatgccgac     1200

tccttcgtga tacgcggtga cgaggtacga caaattgcac ccggccaaac tggaaatatt     1260

gccgactaca attataagtt gccggacgat tttaccggtt gcgtaatagc gtggaactct     1320

aataacctcg actctaaggt aggaggcaac tacaattact tgtaccgact gttcaggaaa     1380

tccaacctga agcccttcga aagagacatc agtacagaga tttatcaagc cgggtccacc     1440

ccttgcaatg gtgtcaaagg cttcaactgc tattttccgt tgcagtctta cggtttccag     1500

ccgacgtacg gtgtgggtta tcaaccctac cgcgttgtgg tgctgagctt tgagcttctc     1560

cacgctccag ccactgtctg cgggcctaag aaatccacaa acctcgttaa gaataaatgc     1620

gtaaatttca acttcaacgg gcttactggc acgggcgtgc ttacggagtc caataagaaa     1680

ttcctgcctt tccagcagtt cggccgcgac atcgcggaca caacagatgc tgtgcgagac     1740

ccacaaaccc tggagattct ggacatcacg ccttgctctt ttggcggtgt cagcgtaata     1800

acgccaggca ccaacaccag taatcaggtc gccgtgcttt atcagggtgt gaactgtacg     1860

gaggtaccgg ttgccataca cgcagaccaa ctcacaccta cgtggagagt ttacagcacc     1920

gggtcaaacg tatttcagac ccgcgcaggc tgtctgatcg gcgcagagca tgtcaataac     1980

tcatacgagt gtgatatacc aatcggagcc ggcatctgtg cgagctatca aacccaaact     2040

aattcacgaa gcgtggccag ccagtccatc attgcctaca cgatgtcttt gggagtagag     2100

aatagcgtgg catactctaa caacagtatc gctattccta ccaacttcac aatatcagtt     2160

actacagaaa tcctcccggt gagcatgact aagacatccg tagactgtac aatgtacatt     2220

tgtggggaca gcacggagtg ttcaaacctg ctgttgcaat acggaagctt ctgcacccag     2280

ctcaaccgag ccctgaccgg cattgccgta gaacaagata agaatacgca ggaagtgttc     2340

gcccaggtta agcagattta caagactccg cctatcaagg acttcggggg tttcaacttt     2400

agtcagattt tgcctgaccc gtcaaagcct agcaaacgaa gttttatcga agatttgttg     2460

tttaacaagg tgactttggc tgatgcggga ttcataaaac aatacggcga ttgccttggc     2520

gatattgcgg cccgagatct catttgcgcg caaaagttca acggtcttac cgtccttccg     2580

cccctgctta cggacgagat gatcgcacaa tacacttcag cactgctggc tggtacaata     2640

accagtgggt ggacattcgg ggctggtgca gcgctccaga tcccctttgc gatgcagatg     2700

gcgtatagat tcaatggcat cggggtcact cagaacgtgc tttatgagaa ccaaaagctt     2760

attgcaaatc aatttaactc tgcgattgga aagattcaag acagcctctc atccacagct     2820

agtgcgcttg gcaagcttca ggacgtcgta aaccaaaacg cccaagctct caacacactc     2880

gttaaacagc tttcctcaaa ctttggggct attagctctg tgctgaatga tattcttagc     2940

agactcgaca aagtcgaggc tgaagtacaa atagatagac tgataacagg tagacttcag     3000

tctctccaaa cctacgtgac acagcagctt ataagagctg ctgagatcag agcttctgcg     3060

aaccttgcgg cgactaaaat gtccgagtgt gtactcgggc agtctaaacg cgtcgacttc     3120

tgtggcaagg gttaccatct catgagtttt ccccaatcag cgccccatgg ggtagttttt     3180

ctgcacgtaa catacgtccc agcccaagaa aagaatttta ccaccgcccc tgcgatttgt     3240

cacgacggaa aagcacactt tccaagagaa ggcgtatttg ttagcaatgg cacccattgg     3300

ttcgtcaccc agagaaactt ttacgaaccg cagattatca cgacagataa tacatttgta     3360

tctggtaatt gtgacgtcgt gatcggcatc gtaaacaaca ctgtttacga ccccctccag     3420

ccagagcttg actcatttaa agaggagctc gacaaatatt ttaagaacca cacaagtcca     3480

gacgtcgact tgggtgacat ttccggcatc aatgcaagtg tggtcaacat ccaaaaggaa     3540

attgacagat tgaacgaggt tgctaagaac cttaatgagt cactcattga cctccaggaa     3600

ctgggaaaat acgaacagta tattaagtgg ccctggtaca tctggctggg atttatcgcg     3660

ggacttatcg cgattgttat ggtgacgata atgctttgct gcatgaccag ctgttgtagt     3720

tgcctcaagg gttgctgctc atgcgggagc tgctgtaaat tcgacgagga cgattctgag     3780

cccgttttga agggagtcaa gcttcactac acgtcacgac tggaggaaga actgcgccga     3840

cgcctgactg aatga                                                      3855


<210>  21
<211>  3852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  21
gccaccatgt tcgtgttcct ggtccttctc cccttggtgt caatccagtg tgtaaatttg       60

acaacgcgca cccaattgcc cccagcatat acgaactctt tcacgagggg cgtatattat      120

ccggataagg tatttcggtc atctgttctg cacagcaccc aggacctctt ccttccattc      180

ttttcaaatg taacttggtt ccatgcgata gtatcaggaa cgaatgggac aaaaaggttc      240

gataatccgg tcttgccgtt caacgatggg gtgtacttcg ccagtaccga aaagtctaac      300

attatacgcg gttggatttt tggcactacg cttgactcaa agacacagtc actcctcatt      360

gtaaataatg ctactaatgt cgtgatcaaa gtttgtgagt tccaattctg caacgacccg      420

ttcctgggag tgtattatca caaaaataat aagtcctgca tggagtcaga gttcagggtt      480

tactcaagtg cgaacaattg cacatttgag tacgtttctc aaccatttct catggatttg      540

gaggggaagc agggaaactt taaaaacctg agagaatttg tttttaagaa cattgatggg      600

tatttcaaga tttatagtaa acacacccct atcaacttgg ttagggatct ccctcaaggt      660

ttctctgctc tcgagcccct tgtagatctg ccaataggca tcaatatcac acgctttcag      720

acactcctcg cacttcatag gagctacctg acgccaggtg actcttcctc aggttggaca      780

gccggcgcag ccgcatacta cgttggctac ctccaaccaa ggacatttct gttgaaatac      840

aacgaaaatg ggaccatcac cgacgcagtc gattgtgctc tcgaccctct ttccgagact      900

aaatgtaccc tcaaaagctt tactgttgag aagggtatct atcagacatc taactttcgg      960

gtgcaaccca ctgagtcaat tgtgcgattc ccaaatatta cgaacctctg tccttttggc     1020

gaggttttta acgccactag gttcgccagt gtatatgctt ggaaccgaaa acggataagc     1080

aattgtgttg ctgactactc cgtcctctac aatagcgcta gtttctcaac atttaagtgt     1140

tacggtgtga gccctacgaa acttaacgat ttgtgcttca ctaacgtcta tgccgacagt     1200

ttcgtaatcc gaggcgatga ggtcaggcaa attgccccgg gccaaacggg gaaaatcgct     1260

gattacaatt ataagttgcc agatgatttt acgggatgtg tcattgcatg gaacagtaat     1320

aacctcgatt caaaggttgg cggaaattat aattacagat atcggctttt tagaaaatct     1380

aaccttaaac catttgagcg ggacataagc acggagattt accaggctgg tagcactccg     1440

tgcaacggtg tagaaggatt caattgctat tttccattgc agtcttatgg attccaaccc     1500

accaatgggg tagggtacca accatacagg gtggtagtcc ttagctttga acttttgcat     1560

gcgccagcta ccgtctgcgg tcccaaaaag agtacgaact tggtaaaaaa taaatgcgtc     1620

aactttaatt ttaacggtct gacgggaacg ggggttctca ccgagtctaa caaaaagttt     1680

ttgccatttc agcagttcgg acgagatatt gccgacacta ccgacgccgt gcgcgatcca     1740

caaaccttgg agatactcga catcacacct tgcagcttcg gtggtgttag cgttattacg     1800

ccaggaacga acacttcaaa tcaggtggcc gtcttgtatc aagatgttaa ctgtacagag     1860

gtgcccgtcg caatacacgc agatcagctc acccctacct ggagagttta ctctacaggc     1920

tctaatgtgt tccaaactag ggcaggctgc ttgattggag ctgaacacgt aaacaactca     1980

tacgagtgcg atatcccgat tggtgcgggt atttgcgcca gctatcagac gcagactaac     2040

tcacgatcag tggcgtcaca gtcaataatt gcgtatacaa tgagtctcgg tgcagagaat     2100

tccgtcgcat actcaaacaa cagcatagcg attccaacta attttaccat tagcgttaca     2160

acggaaatcc tccccgttag catgaccaag acctccgtgg attgcacaat gtacatctgt     2220

ggagacagca ccgagtgctc caatcttctt cttcaatatg ggagcttttg cacacagctg     2280

aaccgcgcgc tcactggcat tgcggtagaa caagacaaaa acacccaaga agtgtttgcg     2340

caggtcaaac agatttacaa gacaccacca atcaaagact tcggggggtt caatttctcc     2400

caaattcttc ctgatccaag caaaccatct aaaaggtcct tcatagaaga cctcctgttc     2460

aataaggtga cactcgcgga cgcagggttt attaagcaat atggagattg tctcggggat     2520

attgcagcga gagatcttat ttgtgctcaa aagtttaatg gcttgactgt cctcccgccc     2580

ttgctcacag acgagatgat agcacaatat accagtgcgc tgcttgcggg cacgattact     2640

tccggatgga ctttcggggc aggagcggcg ctccagattc ctttcgcgat gcaaatggcc     2700

taccgattta acgggattgg cgtcacacaa aacgttcttt acgaaaacca gaaacttatt     2760

gccaaccaat tcaatagtgc aattggtaaa attcaggatt cactctcctc cacggcgtca     2820

gctctcggca agctccaaga cgtggttaac caaaatgcgc aggcgcttaa cacgcttgta     2880

aaacaactct cttctaattt tggcgcgatt agtagcgttc tcaacgatat cttgtcacgc     2940

ttggacaaag tagaagcaga agtccaaata gaccggctga tcactggtcg attgcaatct     3000

ctgcagacat acgtgacgca gcagctcatc cgggcagccg agatccgggc gtccgctaat     3060

ctggccgcaa ccaaaatgag cgagtgtgtc cttgggcaaa gcaaacgcgt ggatttttgc     3120

ggaaagggct accacctcat gagtttcccc caatctgccc cgcacggtgt cgtctttttg     3180

catgtaacgt atgtcccggc gcaggagaaa aatttcacta cagctcccgc catctgtcac     3240

gacggcaagg cacacttccc tcgagaaggg gtgtttgtaa gcaatggaac acactggttc     3300

gtcacccagc ggaattttta tgaacctcag ataatcacaa cagacaacac tttcgtttcc     3360

ggaaactgcg atgtcgtaat tgggatagtg aataataccg tatatgaccc attgcagccg     3420

gagttggact cctttaaaga ggaattggac aaatacttta aaaatcacac ttcacccgat     3480

gtggacctgg gagatatatc cgggattaac gcaagtgtgg ttaacataca aaaggaaatt     3540

gaccgcctta acgaggttgc taagaacttg aatgagtctc tcatagatct ccaggaactg     3600

gggaaatacg agcaatatat caaatggccg tggtacatat ggctcggatt tatagccggc     3660

ctcatagcaa tagttatggt cactataatg ttgtgctgca tgacgtcctg ttgtagttgc     3720

ctcaaggggt gctgttcctg cggtagttgc tgcaaatttg atgaagatga ctccgaaccg     3780

gttctcaagg gagtcaagct tcattatacc tcacgactgg aggaagaact gcgccgacgc     3840

ctgactgaat ga                                                         3852


<210>  22
<211>  3855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  22
gccaccatgt ttgtgttcct ggtccttctc ccgcttgtaa gctcccaatg cgttaacttt       60

actaatcgga cccaactccc gagtgcgtac actaactctt ttacccgggg cgtctattat      120

cctgacaaag tgtttcgatc atctgttttg cactccaccc aagatctctt tcttccattt      180

ttcagcaacg ttacgtggtt ccacgcgata catgttagtg gtactaatgg cacaaagaga      240

tttgacaacc ctgtgctccc gtttaacgat ggggtctatt tcgcttccac tgagaagtcc      300

aacattattc gcggttggat cttcggcacc acactcgatt caaaaaccca aagcttgctc      360

atagttaaca acgccacaaa cgtagtcatt aaagtgtgcg aatttcagtt ttgtaactat      420

ccctttttgg gcgtctacta tcacaagaac aacaagtcct ggatggaatc tgagtttcgg      480

gtctacagtt cagccaacaa ctgtacgttt gagtacgtta gccagccctt tctgatggat      540

cttgaaggga agcaaggaaa tttcaagaat ctttccgagt ttgtgtttaa aaatatagac      600

ggatatttca agatatacag taagcacaca ccgatcaatt tggtacggga tttgccgcaa      660

ggattttccg cccttgagcc ccttgtagat ctccccatcg gaattaacat aaccaggttt      720

caaacactgc tggcgctcca caggagctat ctgaccccgg gcgactcatc cagtgggtgg      780

accgccggag cagccgcata ctacgtgggg tatctccagc ccagaacgtt tctcctcaag      840

tataatgaaa acgggaccat caccgacgcg gttgattgtg cactcgatcc cctcagcgag      900

acaaagtgca cacttaaatc atttaccgtc gagaagggga tctaccaaac atccaacttt      960

cgggtgcagc ctaccgagtc aatagtacgg tttcctaaca tcaccaattt gtgccctttt     1020

ggggaagtat ttaatgcaac ccggtttgcg agcgtatacg cttggaaccg aaaacggata     1080

agtaattgtg ttgcagatta ttctgtgctc tataactcag cttccttctc cacctttaag     1140

tgttacggag tatctccgac aaaattgaat gatctttgtt ttacgaatgt ttacgctgac     1200

tcatttgtta tccgaggtga cgaagtgcgc cagatagccc ccggtcaaac aggcaacatt     1260

gctgattata actacaagtt gcccgatgac ttcacggggt gtgttattgc atggaattca     1320

aataatcttg atagtaaggt agggggtaac tataattacc tttatcgctt gttccgcaaa     1380

tccaatctga aacccttcga aagggatatc agtaccgaga tttatcaagc cggctccaca     1440

ccttgtaacg gagtaaaagg ttttaactgt tatttcccac tgcagagtta cggctttcaa     1500

cccacatacg gggtgggata tcagccctat cgcgttgtgg tcttgtcctt tgaacttctc     1560

cacgcccctg caacagtttg tggtcctaaa aagagtacaa atctggtaaa aaataagtgc     1620

gtcaacttta acttcaacgg actgactggt accggggtcc tcactgagag caacaagaaa     1680

tttttgccct tccagcaatt cgggagggat attgccgata ctaccgatgc tgtacgggac     1740

ccccagacac tcgaaatatt ggacataacc ccgtgctctt ttggaggggt ctctgtgatt     1800

accccgggta cgaacacgag taatcaggtg gcagtgcttt atcagggagt gaattgcaca     1860

gaagtaccag tcgcgatcca tgccgaccag ctcacgccga cctggagggt ttatagtacg     1920

ggtagtaacg ttttccaaac acgggccggt tgtctcatcg gggcagagta cgttaataac     1980

agctatgaat gtgatatacc cataggtgcc gggatttgtg cttcttatca aacccaaacc     2040

aatagcagaa gcgttgcgtc acagtctata atcgcctata cgatgagcct cggagcggaa     2100

aactcagttg cctactccaa caatagcatt gctatcccaa cgaacttcac tattagcgta     2160

accacggaga tccttccagt tagcatgaca aaaactagcg tcgattgcac tatgtatatt     2220

tgcggcgaca gtacagagtg tagtaatttg ctcctgcagt acgggtcttt ctgcacccaa     2280

ttgaaccgag cactgactgg catcgccgtg gaacaagaca aaaacacgca agaagtattt     2340

gcgcaagtca agcagattta caagactccc ccgatcaaag actttggcgg atttaatttt     2400

agccagatac tccccgatcc atctaaacca tcaaaacggt cctttataga agatctcttg     2460

ttcaataaag tgacactcgc ggacgcgggc tttatcaaac agtatgggga ctgccttgga     2520

gatatagctg cgagggactt gatttgcgcc cagaaattca acgggctgac ggttctgccg     2580

ccgctcttga cagacgaaat gattgcacag tatacgagtg ccttgctggc agggactatc     2640

acttccggtt ggaccttcgg cgcaggagca gcgctccaga tcccattcgc tatgcaaatg     2700

gcttaccgat tcaacggaat tggcgtcaca cagaacgtgc tttacgagaa tcaaaagctg     2760

attgccaatc aattcaactc agcgattggc aaaatacaag atagtctctc ttcaactgca     2820

tccgcgctcg gtaagttgca ggacgtagtc aatcagaacg cacaggccct gaacacgctt     2880

gttaaacaac tgtcttcaaa cttcggtgca ataagttccg tacttaatga tatcttgtca     2940

aggttggata aggtcgaagc tgaggtacaa atcgaccgcc ttataacagg cagactccaa     3000

tccctgcaga catacgtgac ccagcaactc attagggcag ccgagatcag agcaagtgcc     3060

aacctcgctg ctattaaaat gtctgaatgc gttttggggc aatctaagcg ggttgatttc     3120

tgcggtaagg gataccactt gatgtccttt cctcagtccg ctcctcatgg ggtagtattt     3180

cttcatgtta catatgtacc agcacaagag aaaaatttta ctactgcccc ggccatatgc     3240

catgatggca aagcgcactt ccctcgggag ggggtttttg tgtctaatgg aacccactgg     3300

ttcgtgactc agcggaattt ctatgaaccc cagattataa ctactgacaa cactttcgtt     3360

tctggaaact gcgatgtagt aataggcata gtaaataata cagtatatga tcccttgcaa     3420

ccagaattgg actcttttaa agaagagctc gacaaatatt ttaaaaacca tacatctcca     3480

gacgttgatc ttggagacat ctctgggata aacgctagct tcgtaaacat acaaaaagaa     3540

atcgataggc ttaacgaggt cgcaaaaaat cttaatgaaa gtcttatcga tttgcaagag     3600

cttggaaagt atgagcagta tatcaaatgg ccttggtata tatggctggg atttattgct     3660

ggtctcatag ccatagttat ggtgacaata atgctgtgct gtatgacgtc atgttgttcc     3720

tgcctgaaag ggtgctgtag ttgtgggagt tgttgcaagt ttgacgagga cgactcagag     3780

cccgttttga aaggtgtgaa acttcattat acatcacgac tggaggaaga actgcgccga     3840

cgcctgactg aatga                                                      3855


<210>  23
<211>  3851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  23
ccaccatgtt cgtatttctc gtcctcctcc cacttgtttc tagtcagtgt gttaatctta       60

caaccagaac tcaattaccc cctgcataca ctaattcttt cacacgtggt gtttattacc      120

ctgacaaagt tttcagatcc tcagttttac attcaactca ggacttgttc ttacctttct      180

tttccaatgt tacttggttc catgctatac atgtctctgg gaccaatggt actaagaggt      240

ttgataaccc tgtcctacca tttaatgatg gtgtttattt tgcttccatt gagaagtcta      300

acataataag aggctggatt tttggtacta ctttagattc gaagacccag tccctactta      360

ttgttaataa cgctactaat gttgttatta aagtctgtga atttcaattt tgtaatgatc      420

catttttggg tgtttattac cacaaaaaca acaaaagttg gatgaaaagt gagttcagag      480

tttattctag tgcgaataat tgcacttttg aatatgtctc tcagcctttt cttatggacc      540

ttgaaggaaa acagggtaat ttcaaaaatc ttagggaatt tgtgtttaag aatattgatg      600

gttattttaa aatatattct aagcacacgc ctattaattt agtgcgtgat ctccctcagg      660

gtttttcggc tttagaacca ttggtagatt tgccaatagg tattaacatc actaggtttc      720

aaactttact tgctttacat agaagttatt tgactcctgg tgattcttct tcaggttgga      780

cagctggtgc tgcagcttat tatgtgggtt atcttcaacc taggactttt ctattaaaat      840

ataatgaaaa tggaaccatt acagatgctg tagactgtgc acttgaccct ctctcagaaa      900

caaagtgtac gttgaaatcc ttcactgtag aaaaaggaat ctatcaaact tctaacttta      960

gagtccaacc aacagaatct attgttagat ttcctaatat tacaaacttg tgcccttttg     1020

gtgaagtttt taacgccacc agatttgcat ctgtttatgc ttggaacagg aagagaatca     1080

gcaactgtgt tgctgattat tctgtcctat ataattccgc atcattttcc acttttaagt     1140

gttatggagt gtctcctact aaattaaatg atctctgctt tactaatgtc tatgcagatt     1200

catttgtaat tagaggtgat gaagtcagac aaatcgctcc agggcaaact ggaaagattg     1260

ctgattataa ttataaatta ccagatgatt ttacaggctg cgttatagct tggaattcta     1320

acaaacttga ttctaaggtt ggtggtaatt ataattaccg ctatagattg tttaggaagt     1380

ctaatctcaa accttttgag agagatattt caactgaaat ctatcaggcc ggtagcacac     1440

cttgtaatgg tgttcagggt tttaattgtt actttccttt acaatcatat ggtttccaac     1500

ccacttatgg tgttggttac caaccataca gagtagtagt actttctttt gaacttctac     1560

atgcaccagc aactgtttgt ggacctaaaa agtctactaa tttggttaaa aacaaatgtg     1620

tcaatttcaa cttcaatggt ttaacaggca caggtgttct tactgagtct aacaaaaagt     1680

ttctgccttt ccaacaattt ggcagagaca ttgatgacac tactgatgct gtccgtgatc     1740

cacagacact tgagattctt gacattacac catgttcttt tggtggtgtc agtgttataa     1800

caccaggaac aaatacttct aaccaggttg ctgttcttta tcagggtgtt aactgcacag     1860

aagtccctgt tgctattcat gcagatcaac ttactcctac ttggcgtgtt tattctacag     1920

gttctaatgt ttttcaaaca cgtgcaggct gtttaatagg ggctgaacat gtcaacaact     1980

catatgagtg tgacataccc attggtgcag gtatatgcgc tagttatcag actcagacta     2040

attctagtgt agctagtcaa tccatcattg cctacactat gtcacttggt gcagaaaatt     2100

cagttgctta ctctaataac tctattgcca tacccattaa ttttactatt agtgttacca     2160

cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg tacatttgtg     2220

gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt acacaattaa     2280

accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa gtttttgcac     2340

aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt aatttttcac     2400

aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat ctacttttca     2460

acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc cttggtgata     2520

ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt ttgccacctt     2580

tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt acaatcactt     2640

ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg caaatggctt     2700

ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa aaattgattg     2760

ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc acagcaagtg     2820

cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac acgcttgtta     2880

aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc cttgcacgtc     2940

ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga cttcaaagtt     3000

tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct tctgctaatc     3060

ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt gatttttgtg     3120

gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta gtcttcttgc     3180

atgtgactta tgtccctgca cacgaaaaga acttcacaac tgctcctgcc atttgtcatg     3240

atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca cactggtttg     3300

taacacaaag gaatttttat gaaccacaaa tcattactac acacaacaca tttgtgtctg     3360

gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct ttgcaacctg     3420

aattagactc attcaaggag gagttagata aatattttaa gaatcataca tcaccagatg     3480

ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa aaagaaattg     3540

accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc caagaacttg     3600

gaaagtatga gcagtatata aaatggccat ggtacatctg gctgggtttt atagctggcc     3660

tgatcgcaat tgtaatggta actataatgt tgtgttgcat gacctcttgc tgcagctgtt     3720

tgaagggatg ctgttcttgc gggagttgct gtaaatttga tgaggatgac agcgagccgg     3780

tgttgaaagg agtgaagctt cattatactt cacgactgga ggaagaactg cgccgacgcc     3840

tgactgaata a                                                          3851


<210>  24
<211>  3789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  24
gccgccacca tggtgaacct gaccacccgg acccagctac ctcctgccta cacaaacagc       60

ttcacccgcg gcgtgtacta ccctgataag gtgttccgga gctctgtgct ccacagcaca      120

caggacctgt tcctgccttt cttcagcaac gtgacgtggt tccacgccat ccacgtgtcc      180

ggcaccaatg gtacaaaaag gtttgacaac cccgtgctcc ccttcaacga cggcgtgtat      240

tttgccagca ctgaaaagtc caatatcatc cgaggatgga tcttcggcac aacgctggac      300

tctaagaccc agagcctgct gatcgtgaac aacgccacca acgtggtgat caaggtgtgc      360

gagtttcagt tctgcaacga tccttttctg ggcgtttact accacaagaa caacaagagc      420

tggatggaaa gcgagttcag agtgtattct agcgccaaca actgtacctt cgaatacgtc      480

agccagcctt tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgagagag      540

ttcgtgttca agaacatcga cggctacttc aagatctaca gcaagcacac acctatcaac      600

ctggtgcggg accttccgca gggattctcc gcgctggaac ccctggtgga cctgcctatt      660

ggcatcaaca tcaccagatt tcagaccctg ctggccctgc acagaagcta cctgacacct      720

ggcgactctt ctagcggctg gaccgccggc gccgccgctt attacgtggg gtacctgcag      780

cccagaacct tcctgctgaa atacaatgag aacggaacca tcaccgatgc cgtggactgc      840

gccctggacc ccctgtctga aaccaagtgc accctgaaat cttttacagt ggaaaaggga      900

atttaccaga cctccaactt tagagtccag cctaccgaaa gcatcgtgcg gttccctaac      960

atcaccaacc tgtgtccttt cggcgaggtt ttcaacgcca cacggttcgc cagcgtatac     1020

gcctggaacc ggaagcggat ctctaactgt gtggcagact actctgtgct atacaactcg     1080

gccagcttta gcaccttcaa gtgctacggc gtgtccccaa ccaagctgaa cgacctgtgc     1140

ttcaccaacg tgtacgccga tagcttcgtg atcagaggcg atgaggtgcg ccagatcgct     1200

cctggacaga ccggaaagat cgctgactac aattacaagc tgcccgacga cttcaccggc     1260

tgcgtgatcg cctggaacag caacaacctg gattccaaag tgggcggcaa ctacaactat     1320

ctgtaccggc tcttcagaaa gtctaacctg aagccctttg agagagacat ctccacagaa     1380

atctaccagg ccggaagcac accttgcaac ggcgtggaag gatttaattg ctattttcct     1440

ctgcagtcct acggcttcca acctaccaac ggagtgggct accagcctta cagagtggtc     1500

gtgctgagct ttgagctgct gcatgcccct gctaccgtgt gtggccctaa gaaaagcacg     1560

aacctggtca agaacaaatg cgtgaacttc aacttcaatg gactgacagg caccggcgtg     1620

ctcacagaga gcaacaagaa gttcctgcca tttcagcagt tcggcagaga catagctgac     1680

accaccgacg ccgtgcggga cccccagacc ctggaaatcc tggatatcac accctgcagc     1740

tttggaggcg tatctgtgat cacacctggc accaacacaa gcaatcaggt cgccgtgctg     1800

taccaagacg tgaactgcac agaggtgccg gtggccatcc acgccgatca gctgaccccc     1860

acctggcggg tgtactccac cggcagcaac gtgttccaaa cccgggccgg ctgcctgatc     1920

ggcgccgaac atgtgaataa cagctacgaa tgtgatatcc ctattggagc cggaatttgc     1980

gccagctacc aaacccaaac caactctcca agaagagcca gaagcgtggc tagccagtct     2040

atcatcgcct acaccatgag cctgggcgct gaaaacagcg tggcttacag caacaacagc     2100

atcgccattc ctactaactt taccatcagc gtgactacag agatcctgcc cgtgagcatg     2160

accaagacca gcgtggactg caccatgtac atctgtggcg attctaccga gtgcagcaac     2220

ttgctactgc agtatggtag cttttgcacc caactgaaca gagccctgac tggcatcgcc     2280

gttgagcagg acaagaacac ccaggaggtg ttcgcccagg tcaagcagat ctataagacc     2340

ccaccaatca aggacttcgg cggcttcaac ttcagccaga tcctgcccga cccgagcaaa     2400

cctagcaaga gaagcttcat cgaggatctt ctgttcaaca aggtgacgct ggccgatgcc     2460

ggcttcatca aacagtacgg cgattgtctg ggcgacatcg ccgccagaga tctgatctgc     2520

gcccagaagt tcaatggcct gaccgtgctg ccgcctctgc tcacagacga gatgatcgcc     2580

cagtacacct ctgccctgtt agcaggcaca atcacgagcg gctggacatt tggcgcgggc     2640

gccgctctgc agatcccttt cgctatgcag atggcctata gatttaatgg catcggcgtg     2700

acccagaatg tgctgtacga gaaccaaaag ctgatcgcta atcagttcaa tagcgccatc     2760

ggaaagatcc aggactctct gagcagcacc gcctccgctc tgggcaaact gcaggacgtg     2820

gtcaatcaaa acgctcaggc tctaaacacc ctggtgaagc agctgtcaag caacttcggc     2880

gccatctcct cagttcttaa cgacatcttg tctagactgg acaaggtgga ggctgaggtg     2940

cagatcgata gactgatcac aggcagatta cagtctctgc agacatacgt gacccaacag     3000

ctgatccggg ccgccgagat cagagcctcc gccaacctgg ctgccaccaa gatgagcgag     3060

tgtgtgcttg gccagtccaa gagagtggac ttctgcggca aaggctacca cctgatgagc     3120

ttcccacaga gcgctcctca cggagttgtg ttcctgcacg tgacctacgt gcctgcccag     3180

gagaagaatt tcacaaccgc ccctgccatc tgccacgacg gtaaggccca cttccccaga     3240

gagggcgtgt tcgtgtctaa tgggacccac tggttcgtga cacagaggaa cttctacgag     3300

ccccagatca tcacaacaga taataccttc gtgtctggca actgcgatgt ggtgatcggc     3360

atcgtgaaca ataccgtgta cgaccctctg cagcccgagc tggacagctt caaagaggaa     3420

ctggacaagt acttcaagaa tcacacctcc cctgacgtgg acctgggaga tatctccggc     3480

atcaacgcct ccgttgtgaa cattcaaaaa gaaatcgaca gactgaacga ggtggccaag     3540

aacctaaacg agtctctgat cgacctgcaa gaactgggca agtacgagca gtacatcaag     3600

tggccttggt acatctggct gggctttatc gccggcctga tcgccattgt gatggtgacc     3660

atcatgctgt gctgcatgac aagttgctgc agctgcctga agggctgttg ttcttgtggc     3720

agctgctgta aattcgacga ggacgatagc gaaccagtgc tgaaaggcgt caagctgcat     3780

tacacctga                                                             3789


<210>  25
<211>  3768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein without furin cleavage site

<400>  25
gccgccacca tggtgaacct gaccacccgg acccagctac caccagccta cacaaacagc       60

ttcacccgcg gcgtgtacta cccagacaag gtgttccgga gctcagtgct ccacagcaca      120

caggacctgt tcctgccatt cttcagcaac gtgacgtggt tccacgccat ccacgtgtcc      180

ggcaccaacg gaacaaaaag gttcgacaac cccgtgctcc ccttcaacga cggcgtgtac      240

ttcgccagca cagaaaagtc caaaatcatc cgaggatgga tcttcggcac aacgctggac      300

tcaaagaccc agagcctgct gatcgtgaac aacgccacca acgtggtgat caaggtgtgc      360

gagttccagt tctgcaacga tccattcctg ggcgtatact accacaagaa caacaagagc      420

tggatggaaa gcgagttcag agtgtactca agcgccaaca actgcacctt cgaatacgtc      480

agccagccat tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgagagag      540

ttcgtgttca agaacatcga cggctacttc aagatctaca gcaagcacac acccatcaac      600

ctggtgcggg acctaccgca gggattctcc gcgctggaac ccctggtgga cctgccaata      660

ggcatcaaca tcaccagatt ccagaccctg ctggccctgc acagaagcta cctgacacca      720

ggcgacagca gcagcggctg gaccgccggc gccgccgcat actacgtggg gtacctgcag      780

cccagaacct tcctgctgaa atacaacgag aacggaacca tcaccgacgc cgtggactgc      840

gccctggacc ccctgagcga aaccaagtgc accctgaaaa gcttcacagt ggaaaaggga      900

atataccaga cctccaactt cagagtccag ccaaccgaaa gcatcgtgcg gttcccaaac      960

atcaccaacc tgtgcccatt cggcgaggta ttcaacgcca cacggttcgc cagcgtatac     1020

gcctggaacc ggaagcggat cagcaactgc gtggcagact acagcgtgct atacaacagc     1080

gccagcttaa gcaccttcaa gtgctacggc gtgtccccaa ccaagctgaa cgacctgtgc     1140

ttcaccaacg tgtacgccga cagcttcgtg atcagaggcg acgaggtgcg ccagatcgca     1200

ccaggacaga ccggaaagat cgcagactac aactacaagc tgcccgacga cttcaccggc     1260

tgcgtgatcg cctggaacag caacaacctg gactccaaag tgggcggcaa ctacaactac     1320

ctgtaccggc tcttcagaaa gagcaacctg aagcccttcg agagagacat cagcacagaa     1380

atctaccagg ccggaagcac accatgcaac ggcgtggaag gattcaactg ctatttccca     1440

ctgcagtcct acggcttcca accaaccaac ggagtgggct accagccata cagagtggtc     1500

gtgctgagct tcgagctgct gcacgcccca gcaaccgtgt gcggcccaaa gaaaagcacg     1560

aacctggtca agaacaaatg cgtgaacttc aacttcaacg gactgacagg caccggcgtg     1620

ctcacagaga gcaacaagaa gttcctgcca ttccagcagt tcggcagaga catagcagac     1680

accaccgacg ccgtgcggga cccccagacc ctggaaatcc tggacatcac accctgcagc     1740

ttcggaggcg taagcgtgat cacaccaggc accaacacaa gcaaccaggt cgccgtgctg     1800

taccaagacg tgaactgcac agaggtgccg gtggccatcc acgccgacca gctgaccccc     1860

acctggcggg tgtactccac cggcagcaac gtgttccaaa cccgggccgg ctgcctgatc     1920

ggcgccgaac acgtgaacaa cagctacgaa tgcgacatcc caatcggagc cggaatctgc     1980

gccagctacc aaacccaaac caacagcgca agccagagca tcatcgccta caccatgagc     2040

ctgggcgcag aaaacagcgt ggcatacagc aacaacagca tcgccatccc aaccaacttc     2100

accatcagcg tgaccacaga gatcctgccc gtgagcatga ccaagaccag cgtggactgc     2160

accatgtaca tctgcggcga cagcaccgag tgcagcaact tgctactgca gtacggaagc     2220

ttctgcaccc aactgaacag agccctgacc ggcatcgccg tcgagcagga caagaacacc     2280

caggaggtgt tcgcccaggt caagcagatc tacaagaccc caccaatcaa ggacttcggc     2340

ggcttcaact tcagccagat cctgcccgac ccgagcaaac caagcaagag aagcttcatc     2400

gaggacctac tgttcaacaa ggtgacgctg gccgacgccg gcttcatcaa acagtacggc     2460

gactgcctgg gcgacatcgc cgccagagac ctgatctgcg cccagaagtt caatggcctg     2520

accgtgctgc cgccactgct cacagacgag atgatcgccc agtacaccag cgccctgtta     2580

gcaggcacaa tcacgagcgg ctggacattc ggcgcgggcg ccgcactgca gatcccattc     2640

gcaatgcaga tggcctacag attcaatggc atcggcgtga cccagaacgt gctgtacgag     2700

aaccaaaagc tgatcgcaaa ccagttcaac agcgccatcg gaaagatcca ggacagcctg     2760

agcagcaccg cctccgcact gggcaaactg caggacgtgg tcaaccaaaa cgcacaggca     2820

ctaaacaccc tggtgaagca gctgtcaagc aacttcggcg ccatcagctc agtcctaaac     2880

gacatcttga gcagactgga caaggtggag gcagaggtgc agatcgacag actgatcaca     2940

ggcagattac agagcctgca gacatacgtg acccaacagc tgatccgggc cgccgagatc     3000

agagcctccg ccaacctggc agccaccaag atgagcgagt gcgtgctagg ccagagcaag     3060

agagtggact tctgcggcaa aggctaccac ctgatgagct tcccacagag cgcaccacac     3120

ggagtagtgt tcctgcacgt gacctacgtg ccagcccagg agaagaactt cacaaccgcc     3180

ccagccatct gccacgacgg aaaggcccac ttccccagag agggcgtgtt cgtgagcaac     3240

gggacccact ggttcgtgac acagaggaac ttctacgagc cccagatcat cacaacagac     3300

aacaccttcg tgagcggcaa ctgcgacgtg gtgatcggca tcgtgaacaa caccgtgtac     3360

gacccactgc agcccgagct ggacagcttc aaagaggaac tggacaagta cttcaagaac     3420

cacacctccc cagacgtgga cctgggagac atcagcggca tcaacgcctc cgtagtgaac     3480

atccaaaaag aaatcgacag actgaacgag gtggccaaga acctaaacga gagcctgatc     3540

gacctgcaag aactgggcaa gtacgagcag tacatcaagt ggccatggta catctggctg     3600

ggcttcatcg ccggcctgat cgccatcgtg atggtgacca tcatgctgtg ctgcatgaca     3660

agctgctgca gctgcctgaa gggctgctgc agctgcggca gctgctgcaa attcgacgag     3720

gacgacagcg aaccagtgct gaaaggcgtc aagctgcact acacctga                  3768


<210>  26
<211>  3633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  26
gccaccatgg tgaacctcac tacgcgaact caactgccgc ctgcttacac taatagtttt       60

acacgaggag tctactaccc ggacaaggtg ttccgctcaa gtgtcttgca cagcacgcaa      120

gacctgttct tgccattttt cagcaatgta acgtggtttc atgccatcca cgtgtcaggt      180

actaacggaa cgaagagatt tgataacccg gtcctcccgt tcaacgacgg ggtttatttt      240

gccagtacag aaaagtccaa tattataagg ggatggattt tcggcacgac tctcgactct      300

aagacacaaa gcttgctcat cgttaataat gctacaaacg tggttataaa agtatgcgag      360

ttccaattct gtaacgaccc ctttctgggg gtttactacc acaaaaataa taagagttgg      420

atggagagcg aattcagagt ttactcttcc gcgaataatt gcaccttcga gtacgtatcc      480

cagccttttc ttatggatct tgaggggaaa caaggtaatt tcaaaaacct tagagaattc      540

gtttttaaga atatagatgg atacttcaag atttattcta aacatacccc aatcaatctg      600

gtgcgcgatc ttcctcaggg tttctctgcg ctggagcctc tcgttgatct gccgatcgga      660

attaatataa ccagattcca gacccttttg gcattgcacc gctcctatct gacacctggg      720

gatagtagtt ccggctggac agcgggcgcc gcggcatact acgttggata tctccaaccc      780

cgcacttttc ttctgaaata taatgagaat ggaacgatta cagacgcagt agattgcgcg      840

cttgaccccc tttcagaaac aaagtgcacg ctgaaatctt tcacggtcga gaagggcatt      900

taccaaacgt ccaatttcag agttcaaccc actgagtcta tagtcaggtt tccgaacatc      960

accaatctct gcccatttgg agaggttttc aacgcaacac ggttcgcctc tgtatacgca     1020

tggaatagaa agagaatatc caattgtgtc gcagactata gtgtcttgta caactctgcg     1080

tcatttagca cttttaaatg ttatggggtg agtccaacta aattgaacga tctctgcttt     1140

acaaatgttt acgcagatag ttttgtgata cgaggcgacg aggtacgaca aattgctcct     1200

ggccagaccg ggaaaatagc ggactacaat tataaactgc cagacgattt caccggctgt     1260

gtgatcgcgt ggaactcaaa caacttggat agtaaggtag gtggtaacta taactacttg     1320

taccggctct tccgcaaaag taatcttaaa ccgttcgagc gggacatctc taccgagatc     1380

tatcaagcag gtagcactcc ctgcaatgga gtcgagggtt ttaattgcta ttttcccctc     1440

caatcatacg ggtttcagcc cacaaatggt gttgggtatc agccctatcg agttgtggtg     1500

ctttcatttg aattgcttca tgcaccggcg acagtttgtg gtcctaaaaa gagtaccaat     1560

ttggttaaaa acaaatgtgt caactttaac tttaacggtc tgactggtac gggggtgctt     1620

acggaatcta ataaaaagtt tcttccgttc cagcaattcg gacgggacat agcggacacg     1680

actgacgcgg ttagagaccc acaaacactc gagattcttg acataacccc ctgttctttc     1740

ggcggagttt ctgtaataac gcctgggaca aatacgtcaa accaggttgc agtattgtac     1800

caggatgtca actgcactga agtgccagtc gcgatccacg cagatcagtt gactccaaca     1860

tggagggtct actctaccgg ttctaacgtg tttcagacca gagccgggtg cctcattggc     1920

gcggaacatg tgaacaattc ttacgaatgc gacataccca tcggcgccgg catttgtgcg     1980

tcataccaaa ctcaaactaa ttcccggagt gtggcctccc aatctattat tgcttatact     2040

atgagtcttg gcgcggaaaa cagtgtagcg tactcaaata actctattgc gatccccacg     2100

aatttcacta taagcgtaac tactgaaatt ttgccggtaa gcatgacgaa aacttcagtg     2160

gactgcacaa tgtacatttg tggtgacagc actgagtgct caaatctcct ccttcagtat     2220

ggttctttct gcacacaact taacagggca cttaccggaa tcgcagtaga acaagacaaa     2280

aacacgcaag aagtattcgc acaggtcaaa caaatttata aaaccccgcc gatcaaggat     2340

tttggagggt ttaacttcag tcagatcctt ccagacccat ccaaacccag caaacggagc     2400

tttattgaag acctgctgtt taataaagtt acccttgcag atgccggttt catcaagcaa     2460

tacggggatt gtctgggcga cattgccgcc cgcgacttga tctgtgccca gaagttcaac     2520

ggtctcacag tcttgccgcc acttctcact gatgaaatga tagcgcagta tacatccgcg     2580

ctgctggctg ggacgataac atctggttgg actttcgggg ccggggcggc tttgcaaatt     2640

cctttcgcca tgcagatggc ctataggttt aacggcatag gagtgactca aaatgttctt     2700

tatgagaatc agaagcttat cgccaaccaa tttaactccg cgattgggaa gatacaggac     2760

tcattgagct ctactgctag cgcccttggc aagcttcaag acgtagtcaa ccaaaatgct     2820

caagcgctca atactctcgt aaagcagctc tcaagcaact ttggcgcgat atcttcagtt     2880

ttgaacgaca tcttgagcag actcgacaag gtggaggctg aagttcaaat tgatcgactg     2940

attacgggcc ggctccagtc actccaaacg tacgtgaccc aacaactcat tagagcggca     3000

gagattagag cgagcgctaa tctggcggcc acaaagatgt cagaatgtgt gcttggtcaa     3060

tccaaaaggg tggatttctg cggaaagggc tatcacttga tgagtttccc gcagtccgcg     3120

cctcatggag ttgttttcct ccacgtaacc tacgttcccg ctcaggaaaa gaatttcacg     3180

acagctccgg caatatgtca tgacggtaaa gcacatttcc ccagggaagg cgtttttgtc     3240

agtaatggaa cccactggtt cgtcacccag cgaaactttt acgagcccca aataataact     3300

actgacaata ccttcgtcag cggcaattgc gacgtcgtca taggcatagt aaataatacg     3360

gtttacgacc ctcttcaacc cgagttggac agcttcaaag aagaacttga taagtatttt     3420

aaaaaccaca ctagcccaga tgtagacctt ggcgacatca gcggtatcaa tgcttccgtt     3480

gtgaacattc aaaaggaaat tgaccgactc aatgaagtag cgaagaactt gaatgagtct     3540

ctgatcgatc ttcaggagct cgggaaatat gagcaataca tcaaatggcc gtcacgactg     3600

gaggaagaac tgcgccgacg cctgactgaa tga                                  3633


<210>  27
<211>  3627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  27
gccaccatgg ttaacctgac aacacgcacc cagttgccac cggcctatac gaactctttc       60

acgcgcggag tgtattatcc cgataaagtc tttcggagtt ctgtgctgca ctctacacaa      120

gatctttttc tgcccttttt ctccaacgtt acgtggttcc atgcaataag tggtacgaat      180

ggtactaaaa ggttcgataa tcccgtactt cccttcaatg acggcgtgta tttcgcgagc      240

acagaaaaga gcaacataat aagaggttgg atttttggga ctaccctgga ctctaaaaca      300

caaagcctcc tcattgttaa taacgcaact aatgtcgtaa taaaggtatg cgaatttcag      360

ttttgtaacg accctttttt gggagtctat cataagaaca ataagtcctg gatggaaagt      420

gaatttaggg tgtatagttc agcgaacaac tgtacatttg agtatgtgtc acagccgttc      480

cttatggatc ttgaagggaa acaggggaac ttcaagaacc tgcgggaatt cgtgtttaaa      540

aatatagacg gttattttaa aatctatagc aaacacaccc caataaacct ggttcgggat      600

cttcctcagg gattttcagc tttggaaccg ttggttgacc tccccatcgg gataaatatc      660

acgcgatttc aaacactgct ggcactgcac cggagttatc tgactcctgg agatagcagc      720

tccggctgga cggctggcgc cgcggcttat tatgtcgggt accttcaacc gcgaacgttt      780

cttttgaagt ataacgaaaa tggcactata accgatgcag tagattgtgc gttggaccct      840

ctttccgaga ctaagtgcac cctgaagtca tttacagtag agaaggggat ataccagaca      900

agcaacttcc gcgtccaacc aacggaaagc atcgtgcgct ttcccaatat tactaacctc      960

tgtccgttcg gcgaggtttt taatgctacc agatttgcct cagtgtatgc ctggaaccgc     1020

aagaggatta gcaactgcgt tgctgactat agcgtgcttt acaattccgc cagttttagt     1080

acgttcaagt gttatggggt aagccctacc aagcttaacg atctttgctt cacgaatgtt     1140

tacgcagact cattcgtaat acgaggtgat gaagtgcgac agatagcccc gggtcagacg     1200

gggaaaatag ccgactacaa ttacaagctc ccggacgact tcacgggctg tgttattgcg     1260

tggaacagca ataacctgga cagtaaagtt ggagggaatt ataactactt gtacaggctg     1320

ttccgcaaat ctaatttgaa accgtttgaa agggacattt ccaccgagat ttaccaagcc     1380

ggcagtaccc catgtaacgg agttgaggga tttaattgct actttccgct ccaatcatat     1440

ggattccagc ctacatacgg cgtcggatat caaccttata gggtggtcgt tctttctttt     1500

gagctgcttc acgccccagc aaccgtttgc ggcccgaaaa aatcaacgaa cttggtcaaa     1560

aacaagtgcg tcaacttcaa tttcaacgga ctgacaggca ccggagtgct caccgagtca     1620

aataaaaaat tcctcccgtt tcaacaattc ggtagagata tagacgacac cacagatgcg     1680

gtacgcgacc ctcagactct tgaaattttg gacattacac catgttcctt cggtggcgtc     1740

tcagtgatta cgcctggcac taacactagc aaccaagtcg cagtacttta tcagggcgtt     1800

aactgtacag aagtaccagt tgcgatacac gcggaccagc tcaccccaac ctggcgcgta     1860

tattctaccg gatctaatgt gtttcaaacg cgggcggggt gcctcatagg tgcagagcat     1920

gtcaataact cctacgaatg tgacattcct ataggagcag gaatatgtgc gagctaccag     1980

actcaaacca attcacacag gagcgtagct agtcagtcca taattgccta cactatgtca     2040

cttggtgctg aaaacagtgt ggcttattca aataattcca tagctattcc aatcaatttc     2100

actattagcg taacaactga gatacttcca gtcagcatga ctaagacttc agttgattgt     2160

acgatgtata tttgtggcga ttctacagaa tgtagtaacc ttctgttgca atacggctcc     2220

ttttgcacac agctcaatcg cgcattgacg ggtatagctg tagagcaaga taaaaacacc     2280

caagaagtct tcgcgcaggt gaagcaaata tataagacac caccgattaa agatttcggt     2340

ggattcaatt ttagccaaat tctgcctgat ccaagcaaac cgtcaaaaag atccttcata     2400

gaggacctgc ttttcaataa ggtaacgctg gcggacgcag ggtttattaa acaatacggc     2460

gattgccttg gtgacattgc tgcacgagac ctcatttgcg cccagaagtt caacggactc     2520

acagtactgc ctccactgct cacagacgag atgatcgccc agtacacatc tgccttgttg     2580

gctggtacga taacttctgg ttggaccttt ggagcgggag cagcacttca gattcccttt     2640

gccatgcaga tggcgtacag attcaacggc attggtgtca cgcagaacgt actgtatgag     2700

aaccagaagt tgatagctaa tcaattcaac tccgcgatag gtaagatcca agacagtctc     2760

tcctcaacag cctccgcact cgggaaactc caggatgtgg taaatcagaa tgcacaggca     2820

ttgaatacgc ttgttaaaca attgtcctca aattttggcg ccatatcatc agtgctcaac     2880

gacatccttg ccagactcga taaagtggag gcagaagtgc agatagatcg cttgattact     2940

gggcgcctcc aatctctcca aacgtacgtg acacaacagc ttattcgggc agcggaaatc     3000

cgcgcctctg cgaaccttgc agcgaccaag atgagcgaat gtgttctcgg gcagtcaaaa     3060

cgagtagatt tctgcggtaa aggatatcat cttatgtcat tcccccaaag cgctccacat     3120

ggtgttgtat ttctgcacgt gacttacgtg ccggcacagg agaagaattt cacaacggct     3180

cccgccatct gtcacgacgg aaaggcacac ttccctaggg agggggtgtt tgtaagcaat     3240

ggtacccact ggtttgtcac acaacgaaac ttctatgaac ctcagataat tacaacgcat     3300

aatacttttg taagtgggaa ctgcgacgtc gttatcggaa tagttaacaa tactgtatat     3360

gatccgttgc agccggagtt ggactcattt aaagaagagc tggacaagta cttcaaaaac     3420

catacaagcc cagatgtaga tcttggggac ataagtggga taaacgccag cgttgtgaac     3480

atacagaagg aaatagacag gctgaatgag gtagcaaaga atcttaacga aagccttata     3540

gatcttcagg aacttgggaa gtacgaacag tacataaagt ggccttcacg actggaggaa     3600

gaactgcgcc gacgcctgac tgaatga                                         3627


<210>  28
<211>  3633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  28
gccaccatgg tcaatttcac tacacgcaca cagctgcccc cggcgtacac taacagtttt       60

acgaggggag tctactaccc ggacaaagtg ttcaggtctt ccgtactcca tagcacacaa      120

gacctcttct tgcctttttt cagcaatgtt acgtggttcc atgcaatcca tgtgagcggt      180

acaaacggga ctaaacgctt tgcaaatcca gtgttgccct tcaacgacgg tgtatacttc      240

gcgagtacag agaagagcaa cataatacgc gggtggatat ttggaacgac gcttgattct      300

aagacacaga gcttgctcat cgtaaacaac gcaacgaatg ttgtaatcaa ggtctgcgaa      360

ttccaattct gcaatgaccc atttcttgga gtttattacc ataagaacaa taagtcttgg      420

atggaatccg agttccgcgt atactctagc gcgaacaact gcaccttcga gtatgtgtcc      480

caaccgtttc tgatggatct tgagggaaag cagggtaatt ttaaaaatct ccgggagttc      540

gttttcaaaa atattgacgg atatttcaaa atctacagca agcatacccc aatcaatttg      600

gtgcggggtc tgccacaagg attttccgct cttgaacctc ttgttgacct tcccatagga      660

atcaatataa ctcggttcca aactcttctt gcgctccata tatcctactt gacgcccgga      720

gattcatcaa gtggctggac ggctggggct gccgcatact acgtcggcta tctgcaacca      780

aggacgtttc tcctcaaata caatgaaaat ggtacgatca ccgacgctgt ggactgcgct      840

ctcgacccgt tgtcagagac gaagtgcacc ttgaagtcct tcaccgtgga aaagggaatt      900

taccagacta gtaacttccg ggtgcagccc acggaatcaa ttgtgcgatt tcctaatatc      960

actaatctct gtcccttcgg ggaagtgttc aatgcgactc gattcgcttc agtatacgct     1020

tggaatagaa agagaatctc aaattgcgtg gctgactatt ccgtactgta taatagtgcg     1080

tcttttagca cgtttaagtg ttatggcgta tccccgacaa agctcaacga tctctgcttc     1140

acgaatgtct atgccgactc cttcgtgata cgcggtgacg aggtacgaca aattgcaccc     1200

ggccaaactg gaaatattgc cgactacaat tataagttgc cggacgattt taccggttgc     1260

gtaatagcgt ggaactctaa taacctcgac tctaaggtag gaggcaacta caattacttg     1320

taccgactgt tcaggaaatc caacctgaag cccttcgaaa gagacatcag tacagagatt     1380

tatcaagccg ggtccacccc ttgcaatggt gtcaaaggct tcaactgcta ttttccgttg     1440

cagtcttacg gtttccagcc gacgtacggt gtgggttatc aaccctaccg cgttgtggtg     1500

ctgagctttg agcttctcca cgctccagcc actgtctgcg ggcctaagaa atccacaaac     1560

ctcgttaaga ataaatgcgt aaatttcaac ttcaacgggc ttactggcac gggcgtgctt     1620

acggagtcca ataagaaatt cctgcctttc cagcagttcg gccgcgacat cgcggacaca     1680

acagatgctg tgcgagaccc acaaaccctg gagattctgg acatcacgcc ttgctctttt     1740

ggcggtgtca gcgtaataac gccaggcacc aacaccagta atcaggtcgc cgtgctttat     1800

cagggtgtga actgtacgga ggtaccggtt gccatacacg cagaccaact cacacctacg     1860

tggagagttt acagcaccgg gtcaaacgta tttcagaccc gcgcaggctg tctgatcggc     1920

gcagagcatg tcaataactc atacgagtgt gatataccaa tcggagccgg catctgtgcg     1980

agctatcaaa cccaaactaa ttcacgaagc gtggccagcc agtccatcat tgcctacacg     2040

atgtctttgg gagtagagaa tagcgtggca tactctaaca acagtatcgc tattcctacc     2100

aacttcacaa tatcagttac tacagaaatc ctcccggtga gcatgactaa gacatccgta     2160

gactgtacaa tgtacatttg tggggacagc acggagtgtt caaacctgct gttgcaatac     2220

ggaagcttct gcacccagct caaccgagcc ctgaccggca ttgccgtaga acaagataag     2280

aatacgcagg aagtgttcgc ccaggttaag cagatttaca agactccgcc tatcaaggac     2340

ttcgggggtt tcaactttag tcagattttg cctgacccgt caaagcctag caaacgaagt     2400

tttatcgaag atttgttgtt taacaaggtg actttggctg atgcgggatt cataaaacaa     2460

tacggcgatt gccttggcga tattgcggcc cgagatctca tttgcgcgca aaagttcaac     2520

ggtcttaccg tccttccgcc cctgcttacg gacgagatga tcgcacaata cacttcagca     2580

ctgctggctg gtacaataac cagtgggtgg acattcgggg ctggtgcagc gctccagatc     2640

ccctttgcga tgcagatggc gtatagattc aatggcatcg gggtcactca gaacgtgctt     2700

tatgagaacc aaaagcttat tgcaaatcaa tttaactctg cgattggaaa gattcaagac     2760

agcctctcat ccacagctag tgcgcttggc aagcttcagg acgtcgtaaa ccaaaacgcc     2820

caagctctca acacactcgt taaacagctt tcctcaaact ttggggctat tagctctgtg     2880

ctgaatgata ttcttagcag actcgacaaa gtcgaggctg aagtacaaat agatagactg     2940

ataacaggta gacttcagtc tctccaaacc tacgtgacac agcagcttat aagagctgct     3000

gagatcagag cttctgcgaa ccttgcggcg actaaaatgt ccgagtgtgt actcgggcag     3060

tctaaacgcg tcgacttctg tggcaagggt taccatctca tgagttttcc ccaatcagcg     3120

ccccatgggg tagtttttct gcacgtaaca tacgtcccag cccaagaaaa gaattttacc     3180

accgcccctg cgatttgtca cgacggaaaa gcacactttc caagagaagg cgtatttgtt     3240

agcaatggca cccattggtt cgtcacccag agaaactttt acgaaccgca gattatcacg     3300

acagataata catttgtatc tggtaattgt gacgtcgtga tcggcatcgt aaacaacact     3360

gtttacgacc ccctccagcc agagcttgac tcatttaaag aggagctcga caaatatttt     3420

aagaaccaca caagtccaga cgtcgacttg ggtgacattt ccggcatcaa tgcaagtgtg     3480

gtcaacatcc aaaaggaaat tgacagattg aacgaggttg ctaagaacct taatgagtca     3540

ctcattgacc tccaggaact gggaaaatac gaacagtata ttaagtggcc ctcacgactg     3600

gaggaagaac tgcgccgacg cctgactgaa tga                                  3633


<210>  29
<211>  3630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  29
gccaccatgg taaatttgac aacgcgcacc caattgcccc cagcatatac gaactctttc       60

acgaggggcg tatattatcc ggataaggta tttcggtcat ctgttctgca cagcacccag      120

gacctcttcc ttccattctt ttcaaatgta acttggttcc atgcgatagt atcaggaacg      180

aatgggacaa aaaggttcga taatccggtc ttgccgttca acgatggggt gtacttcgcc      240

agtaccgaaa agtctaacat tatacgcggt tggatttttg gcactacgct tgactcaaag      300

acacagtcac tcctcattgt aaataatgct actaatgtcg tgatcaaagt ttgtgagttc      360

caattctgca acgacccgtt cctgggagtg tattatcaca aaaataataa gtcctgcatg      420

gagtcagagt tcagggttta ctcaagtgcg aacaattgca catttgagta cgtttctcaa      480

ccatttctca tggatttgga ggggaagcag ggaaacttta aaaacctgag agaatttgtt      540

tttaagaaca ttgatgggta tttcaagatt tatagtaaac acacccctat caacttggtt      600

agggatctcc ctcaaggttt ctctgctctc gagccccttg tagatctgcc aataggcatc      660

aatatcacac gctttcagac actcctcgca cttcatagga gctacctgac gccaggtgac      720

tcttcctcag gttggacagc cggcgcagcc gcatactacg ttggctacct ccaaccaagg      780

acatttctgt tgaaatacaa cgaaaatggg accatcaccg acgcagtcga ttgtgctctc      840

gaccctcttt ccgagactaa atgtaccctc aaaagcttta ctgttgagaa gggtatctat      900

cagacatcta actttcgggt gcaacccact gagtcaattg tgcgattccc aaatattacg      960

aacctctgtc cttttggcga ggtttttaac gccactaggt tcgccagtgt atatgcttgg     1020

aaccgaaaac ggataagcaa ttgtgttgct gactactccg tcctctacaa tagcgctagt     1080

ttctcaacat ttaagtgtta cggtgtgagc cctacgaaac ttaacgattt gtgcttcact     1140

aacgtctatg ccgacagttt cgtaatccga ggcgatgagg tcaggcaaat tgccccgggc     1200

caaacgggga aaatcgctga ttacaattat aagttgccag atgattttac gggatgtgtc     1260

attgcatgga acagtaataa cctcgattca aaggttggcg gaaattataa ttacagatat     1320

cggcttttta gaaaatctaa ccttaaacca tttgagcggg acataagcac ggagatttac     1380

caggctggta gcactccgtg caacggtgta gaaggattca attgctattt tccattgcag     1440

tcttatggat tccaacccac caatggggta gggtaccaac catacagggt ggtagtcctt     1500

agctttgaac ttttgcatgc gccagctacc gtctgcggtc ccaaaaagag tacgaacttg     1560

gtaaaaaata aatgcgtcaa ctttaatttt aacggtctga cgggaacggg ggttctcacc     1620

gagtctaaca aaaagttttt gccatttcag cagttcggac gagatattgc cgacactacc     1680

gacgccgtgc gcgatccaca aaccttggag atactcgaca tcacaccttg cagcttcggt     1740

ggtgttagcg ttattacgcc aggaacgaac acttcaaatc aggtggccgt cttgtatcaa     1800

gatgttaact gtacagaggt gcccgtcgca atacacgcag atcagctcac ccctacctgg     1860

agagtttact ctacaggctc taatgtgttc caaactaggg caggctgctt gattggagct     1920

gaacacgtaa acaactcata cgagtgcgat atcccgattg gtgcgggtat ttgcgccagc     1980

tatcagacgc agactaactc acgatcagtg gcgtcacagt caataattgc gtatacaatg     2040

agtctcggtg cagagaattc cgtcgcatac tcaaacaaca gcatagcgat tccaactaat     2100

tttaccatta gcgttacaac ggaaatcctc cccgttagca tgaccaagac ctccgtggat     2160

tgcacaatgt acatctgtgg agacagcacc gagtgctcca atcttcttct tcaatatggg     2220

agcttttgca cacagctgaa ccgcgcgctc actggcattg cggtagaaca agacaaaaac     2280

acccaagaag tgtttgcgca ggtcaaacag atttacaaga caccaccaat caaagacttc     2340

ggggggttca atttctccca aattcttcct gatccaagca aaccatctaa aaggtccttc     2400

atagaagacc tcctgttcaa taaggtgaca ctcgcggacg cagggtttat taagcaatat     2460

ggagattgtc tcggggatat tgcagcgaga gatcttattt gtgctcaaaa gtttaatggc     2520

ttgactgtcc tcccgccctt gctcacagac gagatgatag cacaatatac cagtgcgctg     2580

cttgcgggca cgattacttc cggatggact ttcggggcag gagcggcgct ccagattcct     2640

ttcgcgatgc aaatggccta ccgatttaac gggattggcg tcacacaaaa cgttctttac     2700

gaaaaccaga aacttattgc caaccaattc aatagtgcaa ttggtaaaat tcaggattca     2760

ctctcctcca cggcgtcagc tctcggcaag ctccaagacg tggttaacca aaatgcgcag     2820

gcgcttaaca cgcttgtaaa acaactctct tctaattttg gcgcgattag tagcgttctc     2880

aacgatatct tgtcacgctt ggacaaagta gaagcagaag tccaaataga ccggctgatc     2940

actggtcgat tgcaatctct gcagacatac gtgacgcagc agctcatccg ggcagccgag     3000

atccgggcgt ccgctaatct ggccgcaacc aaaatgagcg agtgtgtcct tgggcaaagc     3060

aaacgcgtgg atttttgcgg aaagggctac cacctcatga gtttccccca atctgccccg     3120

cacggtgtcg tctttttgca tgtaacgtat gtcccggcgc aggagaaaaa tttcactaca     3180

gctcccgcca tctgtcacga cggcaaggca cacttccctc gagaaggggt gtttgtaagc     3240

aatggaacac actggttcgt cacccagcgg aatttttatg aacctcagat aatcacaaca     3300

gacaacactt tcgtttccgg aaactgcgat gtcgtaattg ggatagtgaa taataccgta     3360

tatgacccat tgcagccgga gttggactcc tttaaagagg aattggacaa atactttaaa     3420

aatcacactt cacccgatgt ggacctggga gatatatccg ggattaacgc aagtgtggtt     3480

aacatacaaa aggaaattga ccgccttaac gaggttgcta agaacttgaa tgagtctctc     3540

atagatctcc aggaactggg gaaatacgag caatatatca aatggccgtc acgactggag     3600

gaagaactgc gccgacgcct gactgaatga                                      3630


<210>  30
<211>  3633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  30
gccaccatgg ttaactttac taatcggacc caactcccga gtgcgtacac taactctttt       60

acccggggcg tctattatcc tgacaaagtg tttcgatcat ctgttttgca ctccacccaa      120

gatctctttc ttccattttt cagcaacgtt acgtggttcc acgcgataca tgttagtggt      180

actaatggca caaagagatt tgacaaccct gtgctcccgt ttaacgatgg ggtctatttc      240

gcttccactg agaagtccaa cattattcgc ggttggatct tcggcaccac actcgattca      300

aaaacccaaa gcttgctcat agttaacaac gccacaaacg tagtcattaa agtgtgcgaa      360

tttcagtttt gtaactatcc ctttttgggc gtctactatc acaagaacaa caagtcctgg      420

atggaatctg agtttcgggt ctacagttca gccaacaact gtacgtttga gtacgttagc      480

cagccctttc tgatggatct tgaagggaag caaggaaatt tcaagaatct ttccgagttt      540

gtgtttaaaa atatagacgg atatttcaag atatacagta agcacacacc gatcaatttg      600

gtacgggatt tgccgcaagg attttccgcc cttgagcccc ttgtagatct ccccatcgga      660

attaacataa ccaggtttca aacactgctg gcgctccaca ggagctatct gaccccgggc      720

gactcatcca gtgggtggac cgccggagca gccgcatact acgtggggta tctccagccc      780

agaacgtttc tcctcaagta taatgaaaac gggaccatca ccgacgcggt tgattgtgca      840

ctcgatcccc tcagcgagac aaagtgcaca cttaaatcat ttaccgtcga gaaggggatc      900

taccaaacat ccaactttcg ggtgcagcct accgagtcaa tagtacggtt tcctaacatc      960

accaatttgt gcccttttgg ggaagtattt aatgcaaccc ggtttgcgag cgtatacgct     1020

tggaaccgaa aacggataag taattgtgtt gcagattatt ctgtgctcta taactcagct     1080

tccttctcca cctttaagtg ttacggagta tctccgacaa aattgaatga tctttgtttt     1140

acgaatgttt acgctgactc atttgttatc cgaggtgacg aagtgcgcca gatagccccc     1200

ggtcaaacag gcaacattgc tgattataac tacaagttgc ccgatgactt cacggggtgt     1260

gttattgcat ggaattcaaa taatcttgat agtaaggtag ggggtaacta taattacctt     1320

tatcgcttgt tccgcaaatc caatctgaaa cccttcgaaa gggatatcag taccgagatt     1380

tatcaagccg gctccacacc ttgtaacgga gtaaaaggtt ttaactgtta tttcccactg     1440

cagagttacg gctttcaacc cacatacggg gtgggatatc agccctatcg cgttgtggtc     1500

ttgtcctttg aacttctcca cgcccctgca acagtttgtg gtcctaaaaa gagtacaaat     1560

ctggtaaaaa ataagtgcgt caactttaac ttcaacggac tgactggtac cggggtcctc     1620

actgagagca acaagaaatt tttgcccttc cagcaattcg ggagggatat tgccgatact     1680

accgatgctg tacgggaccc ccagacactc gaaatattgg acataacccc gtgctctttt     1740

ggaggggtct ctgtgattac cccgggtacg aacacgagta atcaggtggc agtgctttat     1800

cagggagtga attgcacaga agtaccagtc gcgatccatg ccgaccagct cacgccgacc     1860

tggagggttt atagtacggg tagtaacgtt ttccaaacac gggccggttg tctcatcggg     1920

gcagagtacg ttaataacag ctatgaatgt gatataccca taggtgccgg gatttgtgct     1980

tcttatcaaa cccaaaccaa tagcagaagc gttgcgtcac agtctataat cgcctatacg     2040

atgagcctcg gagcggaaaa ctcagttgcc tactccaaca atagcattgc tatcccaacg     2100

aacttcacta ttagcgtaac cacggagatc cttccagtta gcatgacaaa aactagcgtc     2160

gattgcacta tgtatatttg cggcgacagt acagagtgta gtaatttgct cctgcagtac     2220

gggtctttct gcacccaatt gaaccgagca ctgactggca tcgccgtgga acaagacaaa     2280

aacacgcaag aagtatttgc gcaagtcaag cagatttaca agactccccc gatcaaagac     2340

tttggcggat ttaattttag ccagatactc cccgatccat ctaaaccatc aaaacggtcc     2400

tttatagaag atctcttgtt caataaagtg acactcgcgg acgcgggctt tatcaaacag     2460

tatggggact gccttggaga tatagctgcg agggacttga tttgcgccca gaaattcaac     2520

gggctgacgg ttctgccgcc gctcttgaca gacgaaatga ttgcacagta tacgagtgcc     2580

ttgctggcag ggactatcac ttccggttgg accttcggcg caggagcagc gctccagatc     2640

ccattcgcta tgcaaatggc ttaccgattc aacggaattg gcgtcacaca gaacgtgctt     2700

tacgagaatc aaaagctgat tgccaatcaa ttcaactcag cgattggcaa aatacaagat     2760

agtctctctt caactgcatc cgcgctcggt aagttgcagg acgtagtcaa tcagaacgca     2820

caggccctga acacgcttgt taaacaactg tcttcaaact tcggtgcaat aagttccgta     2880

cttaatgata tcttgtcaag gttggataag gtcgaagctg aggtacaaat cgaccgcctt     2940

ataacaggca gactccaatc cctgcagaca tacgtgaccc agcaactcat tagggcagcc     3000

gagatcagag caagtgccaa cctcgctgct attaaaatgt ctgaatgcgt tttggggcaa     3060

tctaagcggg ttgatttctg cggtaaggga taccacttga tgtcctttcc tcagtccgct     3120

cctcatgggg tagtatttct tcatgttaca tatgtaccag cacaagagaa aaattttact     3180

actgccccgg ccatatgcca tgatggcaaa gcgcacttcc ctcgggaggg ggtttttgtg     3240

tctaatggaa cccactggtt cgtgactcag cggaatttct atgaacccca gattataact     3300

actgacaaca ctttcgtttc tggaaactgc gatgtagtaa taggcatagt aaataataca     3360

gtatatgatc ccttgcaacc agaattggac tcttttaaag aagagctcga caaatatttt     3420

aaaaaccata catctccaga cgttgatctt ggagacatct ctgggataaa cgctagcttc     3480

gtaaacatac aaaaagaaat cgataggctt aacgaggtcg caaaaaatct taatgaaagt     3540

cttatcgatt tgcaagagct tggaaagtat gagcagtata tcaaatggcc ttcacgactg     3600

gaggaagaac tgcgccgacg cctgactgaa tga                                  3633


<210>  31
<211>  3630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  31
gccaccatgg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc       60

acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag      120

gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg      180

accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt      240

gcttccattg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg      300

aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa      360

tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg      420

atgaaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct      480

cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt      540

gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta      600

gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt      660

attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt      720

gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct      780

aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca      840

cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc      900

tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt      960

acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct     1020

tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca     1080

tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt     1140

actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca     1200

gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc     1260

gttatagctt ggaattctaa caaacttgat tctaaggttg gtggtaatta taattaccgc     1320

tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc     1380

tatcaggccg gtagcacacc ttgtaatggt gttcagggtt ttaattgtta ctttccttta     1440

caatcatatg gtttccaacc cacttatggt gttggttacc aaccatacag agtagtagta     1500

ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat     1560

ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt     1620

actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgatgacact     1680

actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt     1740

ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat     1800

cagggtgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact     1860

tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg     1920

gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct     1980

agttatcaga ctcagactaa ttctagtgta gctagtcaat ccatcattgc ctacactatg     2040

tcacttggtg cagaaaattc agttgcttac tctaataact ctattgccat acccattaat     2100

tttactatta gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat     2160

tgtacaatgt acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc     2220

agtttttgta cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac     2280

acccaagaag tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt     2340

ggtggtttta atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt     2400

attgaagatc tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat     2460

ggtgattgcc ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc     2520

cttactgttt tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg     2580

ttagcgggta caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca     2640

tttgctatgc aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat     2700

gagaaccaaa aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca     2760

ctttcttcca cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa     2820

gctttaaaca cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta     2880

aatgatatcc ttgcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc     2940

acaggcagac ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa     3000

atcagagctt ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca     3060

aaaagagttg atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct     3120

catggtgtag tcttcttgca tgtgacttat gtccctgcac acgaaaagaa cttcacaact     3180

gctcctgcca tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca     3240

aatggcacac actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca     3300

cacaacacat ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt     3360

tatgatcctt tgcaacctga attagactca ttcaaggagg agttagataa atattttaag     3420

aatcatacat caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta     3480

aacattcaaa aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc     3540

atcgatctcc aagaacttgg aaagtatgag cagtatataa aatggccatc acgactggag     3600

gaagaactgc gccgacgcct gactgaataa                                      3630


<210>  32
<211>  3609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding the spike protein extracellular domain

<400>  32
gccgccacca tggtgaacct gaccacccgg acccagctac ctcctgccta cacaaacagc       60

ttcacccgcg gcgtgtacta ccctgataag gtgttccgga gctctgtgct ccacagcaca      120

caggacctgt tcctgccttt cttcagcaac gtgacgtggt tccacgccat ccacgtgtcc      180

ggcaccaatg gtacaaaaag gtttgacaac cccgtgctcc ccttcaacga cggcgtgtat      240

tttgccagca ctgaaaagtc caatatcatc cgaggatgga tcttcggcac aacgctggac      300

tctaagaccc agagcctgct gatcgtgaac aacgccacca acgtggtgat caaggtgtgc      360

gagtttcagt tctgcaacga tccttttctg ggcgtttact accacaagaa caacaagagc      420

tggatggaaa gcgagttcag agtgtattct agcgccaaca actgtacctt cgaatacgtc      480

agccagcctt tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgagagag      540

ttcgtgttca agaacatcga cggctacttc aagatctaca gcaagcacac acctatcaac      600

ctggtgcggg accttccgca gggattctcc gcgctggaac ccctggtgga cctgcctatt      660

ggcatcaaca tcaccagatt tcagaccctg ctggccctgc acagaagcta cctgacacct      720

ggcgactctt ctagcggctg gaccgccggc gccgccgctt attacgtggg gtacctgcag      780

cccagaacct tcctgctgaa atacaatgag aacggaacca tcaccgatgc cgtggactgc      840

gccctggacc ccctgtctga aaccaagtgc accctgaaat cttttacagt ggaaaaggga      900

atttaccaga cctccaactt tagagtccag cctaccgaaa gcatcgtgcg gttccctaac      960

atcaccaacc tgtgtccttt cggcgaggtt ttcaacgcca cacggttcgc cagcgtatac     1020

gcctggaacc ggaagcggat ctctaactgt gtggcagact actctgtgct atacaactcg     1080

gccagcttta gcaccttcaa gtgctacggc gtgtccccaa ccaagctgaa cgacctgtgc     1140

ttcaccaacg tgtacgccga tagcttcgtg atcagaggcg atgaggtgcg ccagatcgct     1200

cctggacaga ccggaaagat cgctgactac aattacaagc tgcccgacga cttcaccggc     1260

tgcgtgatcg cctggaacag caacaacctg gattccaaag tgggcggcaa ctacaactat     1320

ctgtaccggc tcttcagaaa gtctaacctg aagccctttg agagagacat ctccacagaa     1380

atctaccagg ccggaagcac accttgcaac ggcgtggaag gatttaattg ctattttcct     1440

ctgcagtcct acggcttcca acctaccaac ggagtgggct accagcctta cagagtggtc     1500

gtgctgagct ttgagctgct gcatgcccct gctaccgtgt gtggccctaa gaaaagcacg     1560

aacctggtca agaacaaatg cgtgaacttc aacttcaatg gactgacagg caccggcgtg     1620

ctcacagaga gcaacaagaa gttcctgcca tttcagcagt tcggcagaga catagctgac     1680

accaccgacg ccgtgcggga cccccagacc ctggaaatcc tggatatcac accctgcagc     1740

tttggaggcg tatctgtgat cacacctggc accaacacaa gcaatcaggt cgccgtgctg     1800

taccaagacg tgaactgcac agaggtgccg gtggccatcc acgccgatca gctgaccccc     1860

acctggcggg tgtactccac cggcagcaac gtgttccaaa cccgggccgg ctgcctgatc     1920

ggcgccgaac atgtgaataa cagctacgaa tgtgatatcc ctattggagc cggaatttgc     1980

gccagctacc aaacccaaac caactctcca agaagagcca gaagcgtggc tagccagtct     2040

atcatcgcct acaccatgag cctgggcgct gaaaacagcg tggcttacag caacaacagc     2100

atcgccattc ctactaactt taccatcagc gtgactacag agatcctgcc cgtgagcatg     2160

accaagacca gcgtggactg caccatgtac atctgtggcg attctaccga gtgcagcaac     2220

ttgctactgc agtatggtag cttttgcacc caactgaaca gagccctgac tggcatcgcc     2280

gttgagcagg acaagaacac ccaggaggtg ttcgcccagg tcaagcagat ctataagacc     2340

ccaccaatca aggacttcgg cggcttcaac ttcagccaga tcctgcccga cccgagcaaa     2400

cctagcaaga gaagcttcat cgaggatctt ctgttcaaca aggtgacgct ggccgatgcc     2460

ggcttcatca aacagtacgg cgattgtctg ggcgacatcg ccgccagaga tctgatctgc     2520

gcccagaagt tcaatggcct gaccgtgctg ccgcctctgc tcacagacga gatgatcgcc     2580

cagtacacct ctgccctgtt agcaggcaca atcacgagcg gctggacatt tggcgcgggc     2640

gccgctctgc agatcccttt cgctatgcag atggcctata gatttaatgg catcggcgtg     2700

acccagaatg tgctgtacga gaaccaaaag ctgatcgcta atcagttcaa tagcgccatc     2760

ggaaagatcc aggactctct gagcagcacc gcctccgctc tgggcaaact gcaggacgtg     2820

gtcaatcaaa acgctcaggc tctaaacacc ctggtgaagc agctgtcaag caacttcggc     2880

gccatctcct cagttcttaa cgacatcttg tctagactgg acaaggtgga ggctgaggtg     2940

cagatcgata gactgatcac aggcagatta cagtctctgc agacatacgt gacccaacag     3000

ctgatccggg ccgccgagat cagagcctcc gccaacctgg ctgccaccaa gatgagcgag     3060

tgtgtgcttg gccagtccaa gagagtggac ttctgcggca aaggctacca cctgatgagc     3120

ttcccacaga gcgctcctca cggagttgtg ttcctgcacg tgacctacgt gcctgcccag     3180

gagaagaatt tcacaaccgc ccctgccatc tgccacgacg gtaaggccca cttccccaga     3240

gagggcgtgt tcgtgtctaa tgggacccac tggttcgtga cacagaggaa cttctacgag     3300

ccccagatca tcacaacaga taataccttc gtgtctggca actgcgatgt ggtgatcggc     3360

atcgtgaaca ataccgtgta cgaccctctg cagcccgagc tggacagctt caaagaggaa     3420

ctggacaagt acttcaagaa tcacacctcc cctgacgtgg acctgggaga tatctccggc     3480

atcaacgcct ccgttgtgaa cattcaaaaa gaaatcgaca gactgaacga ggtggccaag     3540

aacctaaacg agtctctgat cgacctgcaa gaactgggca agtacgagca gtacatcaag     3600

tggccataa                                                             3609


<210>  33
<211>  3609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain without the furin sequence

<400>  33
gccgccacca tggtgaacct gaccacccgg acccagctac caccagccta cacaaacagc       60

ttcacccgcg gcgtgtacta cccagacaag gtgttccgga gctcagtgct ccacagcaca      120

caggacctgt tcctgccatt cttcagcaac gtgacgtggt tccacgccat ccacgtgtcc      180

ggcaccaacg gaacaaaaag gttcgacaac cccgtgctcc ccttcaacga cggcgtgtac      240

ttcgccagca cagaaaagtc caaaatcatc cgaggatgga tcttcggcac aacgctggac      300

tcaaagaccc agagcctgct gatcgtgaac aacgccacca acgtggtgat caaggtgtgc      360

gagttccagt tctgcaacga tccattcctg ggcgtatact accacaagaa caacaagagc      420

tggatggaaa gcgagttcag agtgtactca agcgccaaca actgcacctt cgaatacgtc      480

agccagccat tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgagagag      540

ttcgtgttca agaacatcga cggctacttc aagatctaca gcaagcacac acccatcaac      600

ctggtgcggg acctaccgca gggattctcc gcgctggaac ccctggtgga cctgccaata      660

ggcatcaaca tcaccagatt ccagaccctg ctggccctgc acagaagcta cctgacacca      720

ggcgacagca gcagcggctg gaccgccggc gccgccgcat actacgtggg gtacctgcag      780

cccagaacct tcctgctgaa atacaacgag aacggaacca tcaccgacgc cgtggactgc      840

gccctggacc ccctgagcga aaccaagtgc accctgaaaa gcttcacagt ggaaaaggga      900

atataccaga cctccaactt cagagtccag ccaaccgaaa gcatcgtgcg gttcccaaac      960

atcaccaacc tgtgcccatt cggcgaggta ttcaacgcca cacggttcgc cagcgtatac     1020

gcctggaacc ggaagcggat cagcaactgc gtggcagact acagcgtgct atacaacagc     1080

gccagcttaa gcaccttcaa gtgctacggc gtgtccccaa ccaagctgaa cgacctgtgc     1140

ttcaccaacg tgtacgccga cagcttcgtg atcagaggcg acgaggtgcg ccagatcgca     1200

ccaggacaga ccggaaagat cgcagactac aactacaagc tgcccgacga cttcaccggc     1260

tgcgtgatcg cctggaacag caacaacctg gactccaaag tgggcggcaa ctacaactac     1320

ctgtaccggc tcttcagaaa gagcaacctg aagcccttcg agagagacat cagcacagaa     1380

atctaccagg ccggaagcac accatgcaac ggcgtggaag gattcaactg ctatttccca     1440

ctgcagtcct acggcttcca accaaccaac ggagtgggct accagccata cagagtggtc     1500

gtgctgagct tcgagctgct gcacgcccca gcaaccgtgt gcggcccaaa gaaaagcacg     1560

aacctggtca agaacaaatg cgtgaacttc aacttcaacg gactgacagg caccggcgtg     1620

ctcacagaga gcaacaagaa gttcctgcca ttccagcagt tcggcagaga catagcagac     1680

accaccgacg ccgtgcggga cccccagacc ctggaaatcc tggacatcac accctgcagc     1740

ttcggaggcg taagcgtgat cacaccaggc accaacacaa gcaaccaggt cgccgtgctg     1800

taccaagacg tgaactgcac agaggtgccg gtggccatcc acgccgacca gctgaccccc     1860

acctggcggg tgtactccac cggcagcaac gtgttccaaa cccgggccgg ctgcctgatc     1920

ggcgccgaac acgtgaacaa cagctacgaa tgcgacatcc caatcggagc cggaatctgc     1980

gccagctacc aaacccaaac caacagccca agaagagcca gaagcgtggc aagccagagc     2040

atcatcgcct acaccatgag cctgggcgca gaaaacagcg tggcatacag caacaacagc     2100

atcgccatcc caaccaactt caccatcagc gtgaccacag agatcctgcc cgtgagcatg     2160

accaagacca gcgtggactg caccatgtac atctgcggcg acagcaccga gtgcagcaac     2220

ttgctactgc agtacggaag cttctgcacc caactgaaca gagccctgac cggcatcgcc     2280

gtcgagcagg acaagaacac ccaggaggtg ttcgcccagg tcaagcagat ctacaagacc     2340

ccaccaatca aggacttcgg cggcttcaac ttcagccaga tcctgcccga cccgagcaaa     2400

ccaagcaaga gaagcttcat cgaggaccta ctgttcaaca aggtgacgct ggccgacgcc     2460

ggcttcatca aacagtacgg cgactgcctg ggcgacatcg ccgccagaga cctgatctgc     2520

gcccagaagt tcaatggcct gaccgtgctg ccgccactgc tcacagacga gatgatcgcc     2580

cagtacacca gcgccctgtt agcaggcaca atcacgagcg gctggacatt cggcgcgggc     2640

gccgcactgc agatcccatt cgcaatgcag atggcctaca gattcaatgg catcggcgtg     2700

acccagaacg tgctgtacga gaaccaaaag ctgatcgcaa accagttcaa cagcgccatc     2760

ggaaagatcc aggacagcct gagcagcacc gcctccgcac tgggcaaact gcaggacgtg     2820

gtcaaccaaa acgcacaggc actaaacacc ctggtgaagc agctgtcaag caacttcggc     2880

gccatcagct cagtcctaaa cgacatcttg agcagactgg acaaggtgga ggcagaggtg     2940

cagatcgaca gactgatcac aggcagatta cagagcctgc agacatacgt gacccaacag     3000

ctgatccggg ccgccgagat cagagcctcc gccaacctgg cagccaccaa gatgagcgag     3060

tgcgtgctag gccagagcaa gagagtggac ttctgcggca aaggctacca cctgatgagc     3120

ttcccacaga gcgcaccaca cggagtagtg ttcctgcacg tgacctacgt gccagcccag     3180

gagaagaact tcacaaccgc cccagccatc tgccacgacg gaaaggccca cttccccaga     3240

gagggcgtgt tcgtgagcaa cgggacccac tggttcgtga cacagaggaa cttctacgag     3300

ccccagatca tcacaacaga caacaccttc gtgagcggca actgcgacgt ggtgatcggc     3360

atcgtgaaca acaccgtgta cgacccactg cagcccgagc tggacagctt caaagaggaa     3420

ctggacaagt acttcaagaa ccacacctcc ccagacgtgg acctgggaga catcagcggc     3480

atcaacgcct ccgtagtgaa catccaaaaa gaaatcgaca gactgaacga ggtggccaag     3540

aacctaaacg agagcctgat cgacctgcaa gaactgggca agtacgagca gtacatcaag     3600

tggccataa                                                             3609


<210>  34
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD74 transmembrane and cytoplasmic domain

<400>  34

His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val Met 
1               5                   10                  15      


Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met Leu 
            20                  25                  30          


Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala Leu 
        35                  40                  45              


Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln Ala 
    50                  55                  60                  


Thr Thr Ala Tyr Phe Leu Tyr 
65                  70      


<210>  35
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA fragment

<400>  35

Met Val Lys Cys Ala Thr Leu Ser Val Asp Ser Gly Gln Ala Ser Asp 
1               5                   10                  15      


Ser Ser Ala Ala Gln Thr Tyr Ser Gly Gly Lys Arg Asp Ser Ser Lys 
            20                  25                  30          


Arg Arg Trp Met Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly 
        35                  40                  45              


Leu Leu Val Leu Gly Ala Ile Ile Gly Val 
    50                  55              


<210>  36
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting moiety comprising CD74 cytoplasmic domain fused to HLA transmembrane domain

<400>  36

His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val Met 
1               5                   10                  15      


Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met Leu 
            20                  25                  30          


Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met Val 
        35                  40                  45              


Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu Gly 
    50                  55                  60                  


Ala Ile Ile Gly Val 
65                  


<210>  37
<211>  1330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein comprising CD74 cytoplasmic domain and transmembrane domain and spike protein

<400>  37

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Val Asn Leu Thr Thr Arg Thr Gln 
65                  70                  75                  80  


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
                85                  90                  95      


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
            100                 105                 110         


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
        115                 120                 125             


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
    130                 135                 140                 


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
145                 150                 155                 160 


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
                165                 170                 175     


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
            180                 185                 190         


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
        195                 200                 205             


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
    210                 215                 220                 


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
225                 230                 235                 240 


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
                245                 250                 255     


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
            260                 265                 270         


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
        275                 280                 285             


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
    290                 295                 300                 


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
305                 310                 315                 320 


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
                325                 330                 335     


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
            340                 345                 350         


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
        355                 360                 365             


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
    370                 375                 380                 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
385                 390                 395                 400 


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
                405                 410                 415     


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
            420                 425                 430         


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
        435                 440                 445             


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
    450                 455                 460                 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
465                 470                 475                 480 


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
                485                 490                 495     


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
            500                 505                 510         


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
        515                 520                 525             


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
    530                 535                 540                 


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
545                 550                 555                 560 


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
                565                 570                 575     


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
            580                 585                 590         


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
        595                 600                 605             


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
    610                 615                 620                 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
625                 630                 635                 640 


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
                645                 650                 655     


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
            660                 665                 670         


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
        675                 680                 685             


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
    690                 695                 700                 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
705                 710                 715                 720 


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
                725                 730                 735     


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
            740                 745                 750         


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
        755                 760                 765             


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
    770                 775                 780                 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
785                 790                 795                 800 


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
                805                 810                 815     


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
            820                 825                 830         


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
        835                 840                 845             


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
    850                 855                 860                 


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
865                 870                 875                 880 


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
                885                 890                 895     


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
            900                 905                 910         


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
        915                 920                 925             


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
    930                 935                 940                 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
945                 950                 955                 960 


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
                965                 970                 975     


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
            980                 985                 990         


Asp Ser Leu Ser Ser Thr Ala Ser  Ala Leu Gly Lys Leu  Gln Asp Val 
        995                 1000                 1005             


Val Asn  Gln Asn Ala Gln Ala  Leu Asn Thr Leu Val  Lys Gln Leu 
    1010                 1015                 1020             


Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val Leu Asn  Asp Ile Leu 
    1025                 1030                 1035             


Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val Gln Ile  Asp Arg Leu 
    1040                 1045                 1050             


Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
    1055                 1060                 1065             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1070                 1075                 1080             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1085                 1090                 1095             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1100                 1105                 1110             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1115                 1120                 1125             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1130                 1135                 1140             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1145                 1150                 1155             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1160                 1165                 1170             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1175                 1180                 1185             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1190                 1195                 1200             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1205                 1210                 1215             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1220                 1225                 1230             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1235                 1240                 1245             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1250                 1255                 1260             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1265                 1270                 1275             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1280                 1285                 1290             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1295                 1300                 1305             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1310                 1315                 1320             


Gly Val  Lys Leu His Tyr Thr  
    1325                 1330 


<210>  38
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein comprising CD74 cytoplasmic domain and extracellular domain with spike extracellular domain

<400>  38

Met Ala Ala Thr Met Ala His Arg Arg Arg Ser Arg Ser Cys Arg Glu 
1               5                   10                  15      


Asp Gln Lys Pro Val Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn 
            20                  25                  30          


Glu Gln Leu Pro Met Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys 
        35                  40                  45              


Cys Ser Arg Gly Ala Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu 
    50                  55                  60                  


Leu Leu Ala Gly Gln Ala Thr Thr Ala Tyr Phe Leu Tyr Val Asn Leu 
65                  70                  75                  80  


Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg 
                85                  90                  95      


Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser 
            100                 105                 110         


Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His 
        115                 120                 125             


Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
    130                 135                 140                 


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
145                 150                 155                 160 


Lys Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
                165                 170                 175     


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
            180                 185                 190         


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His 
        195                 200                 205             


Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser 
    210                 215                 220                 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
225                 230                 235                 240 


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
                245                 250                 255     


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
            260                 265                 270         


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
        275                 280                 285             


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
    290                 295                 300                 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
305                 310                 315                 320 


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
                325                 330                 335     


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
            340                 345                 350         


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
        355                 360                 365             


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
    370                 375                 380                 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
385                 390                 395                 400 


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
                405                 410                 415     


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
            420                 425                 430         


Ser Ala Ser Leu Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
        435                 440                 445             


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
    450                 455                 460                 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
465                 470                 475                 480 


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
                485                 490                 495     


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
            500                 505                 510         


Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
        515                 520                 525             


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly 
    530                 535                 540                 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
545                 550                 555                 560 


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
                565                 570                 575     


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
            580                 585                 590         


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
        595                 600                 605             


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
    610                 615                 620                 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
625                 630                 635                 640 


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
                645                 650                 655     


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
            660                 665                 670         


Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
        675                 680                 685             


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
    690                 695                 700                 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
705                 710                 715                 720 


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
                725                 730                 735     


Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln 
            740                 745                 750         


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
        755                 760                 765             


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
    770                 775                 780                 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
785                 790                 795                 800 


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
                805                 810                 815     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
            820                 825                 830         


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
        835                 840                 845             


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
    850                 855                 860                 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
865                 870                 875                 880 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
                885                 890                 895     


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
            900                 905                 910         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        915                 920                 925             


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
    930                 935                 940                 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
945                 950                 955                 960 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                965                 970                 975     


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
            980                 985                 990         


Ile Gly Lys Ile Gln Asp Ser Leu  Ser Ser Thr Ala Ser  Ala Leu Gly 
        995                 1000                 1005             


Lys Leu  Gln Asp Val Val Asn  Gln Asn Ala Gln Ala  Leu Asn Thr 
    1010                 1015                 1020             


Leu Val  Lys Gln Leu Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val 
    1025                 1030                 1035             


Leu Asn  Asp Ile Leu Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val 
    1040                 1045                 1050             


Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr 
    1055                 1060                 1065             


Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
    1070                 1075                 1080             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1085                 1090                 1095             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1100                 1105                 1110             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1115                 1120                 1125             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1130                 1135                 1140             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1145                 1150                 1155             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1160                 1165                 1170             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1175                 1180                 1185             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1190                 1195                 1200             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1205                 1210                 1215             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1220                 1225                 1230             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1235                 1240                 1245             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1250                 1255                 1260             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  
    1265                 1270                 1275 


<210>  39
<211>  1323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein comprising CD74 cytoplasmic domain and transmembrane domain with spike lacking furin cleavage site

<400>  39

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Val Asn Leu Thr Thr Arg Thr Gln 
65                  70                  75                  80  


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
                85                  90                  95      


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
            100                 105                 110         


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
        115                 120                 125             


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
    130                 135                 140                 


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
145                 150                 155                 160 


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
                165                 170                 175     


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
            180                 185                 190         


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
        195                 200                 205             


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
    210                 215                 220                 


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
225                 230                 235                 240 


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
                245                 250                 255     


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
            260                 265                 270         


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
        275                 280                 285             


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
    290                 295                 300                 


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
305                 310                 315                 320 


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
                325                 330                 335     


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
            340                 345                 350         


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
        355                 360                 365             


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
    370                 375                 380                 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
385                 390                 395                 400 


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
                405                 410                 415     


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
            420                 425                 430         


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
        435                 440                 445             


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
    450                 455                 460                 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
465                 470                 475                 480 


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
                485                 490                 495     


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
            500                 505                 510         


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
        515                 520                 525             


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
    530                 535                 540                 


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
545                 550                 555                 560 


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
                565                 570                 575     


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
            580                 585                 590         


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
        595                 600                 605             


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
    610                 615                 620                 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
625                 630                 635                 640 


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
                645                 650                 655     


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
            660                 665                 670         


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
        675                 680                 685             


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
    690                 695                 700                 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
705                 710                 715                 720 


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
                725                 730                 735     


Ser Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
            740                 745                 750         


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
        755                 760                 765             


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
    770                 775                 780                 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
785                 790                 795                 800 


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
                805                 810                 815     


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
            820                 825                 830         


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
        835                 840                 845             


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
    850                 855                 860                 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
865                 870                 875                 880 


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
                885                 890                 895     


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
            900                 905                 910         


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
        915                 920                 925             


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
    930                 935                 940                 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
945                 950                 955                 960 


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
                965                 970                 975     


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
            980                 985                 990         


Ser Ala Leu Gly Lys Leu Gln Asp  Val Val Asn Gln Asn  Ala Gln Ala 
        995                 1000                 1005             


Leu Asn  Thr Leu Val Lys Gln  Leu Ser Ser Asn Phe  Gly Ala Ile 
    1010                 1015                 1020             


Ser Ser  Val Leu Asn Asp Ile  Leu Ser Arg Leu Asp  Lys Val Glu 
    1025                 1030                 1035             


Ala Glu  Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
    1040                 1045                 1050             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1055                 1060                 1065             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1070                 1075                 1080             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1085                 1090                 1095             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1100                 1105                 1110             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1115                 1120                 1125             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1130                 1135                 1140             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1145                 1150                 1155             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1160                 1165                 1170             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1175                 1180                 1185             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1190                 1195                 1200             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1205                 1210                 1215             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1220                 1225                 1230             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1235                 1240                 1245             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro 
    1250                 1255                 1260             


Trp Tyr  Ile Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val 
    1265                 1270                 1275             


Met Val  Thr Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys 
    1280                 1285                 1290             


Leu Lys  Gly Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu 
    1295                 1300                 1305             


Asp Asp  Ser Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1310                 1315                 1320             


<210>  40
<211>  4002
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding the CD74 Cytoplasmic domain and transmembrane domain with full length spike
       

<400>  40
gccgccacca ugcacaggag gagaagcagg agcugucggg aagaucagaa gccagucaug       60

gaugaccagc gcgaccuuau cuccaacaau gagcaacugc ccaugcuggg ccggcgcccu      120

ggggccccgg agagcaagug cagccgcgga gcccuguaca caggcuuuuc cauccuggug      180

acucugcucc ucgcuggcca ggccaccacc gccuacuucc uguacgugaa ccugaccacc      240

cggacccagc uaccuccugc cuacacaaac agcuucaccc gcggcgugua cuacccugau      300

aagguguucc ggagcucugu gcuccacagc acacaggacc uguuccugcc uuucuucagc      360

aacgugacgu gguuccacgc cauccacgug uccggcacca augguacaaa aagguuugac      420

aaccccgugc uccccuucaa cgacggcgug uauuuugcca gcacugaaaa guccaauauc      480

auccgaggau ggaucuucgg cacaacgcug gacucuaaga cccagagccu gcugaucgug      540

aacaacgcca ccaacguggu gaucaaggug ugcgaguuuc aguucugcaa cgauccuuuu      600

cugggcguuu acuaccacaa gaacaacaag agcuggaugg aaagcgaguu cagaguguau      660

ucuagcgcca acaacuguac cuucgaauac gucagccagc cuuuccugau ggaccuggaa      720

ggcaagcagg gcaacuucaa gaaccugaga gaguucgugu ucaagaacau cgacggcuac      780

uucaagaucu acagcaagca cacaccuauc aaccuggugc gggaccuucc gcagggauuc      840

uccgcgcugg aaccccuggu ggaccugccu auuggcauca acaucaccag auuucagacc      900

cugcuggccc ugcacagaag cuaccugaca ccuggcgacu cuucuagcgg cuggaccgcc      960

ggcgccgccg cuuauuacgu gggguaccug cagcccagaa ccuuccugcu gaaauacaau     1020

gagaacggaa ccaucaccga ugccguggac ugcgcccugg acccccuguc ugaaaccaag     1080

ugcacccuga aaucuuuuac aguggaaaag ggaauuuacc agaccuccaa cuuuagaguc     1140

cagccuaccg aaagcaucgu gcgguucccu aacaucacca accugugucc uuucggcgag     1200

guuuucaacg ccacacgguu cgccagcgua uacgccugga accggaagcg gaucucuaac     1260

uguguggcag acuacucugu gcuauacaac ucggccagcu uuagcaccuu caagugcuac     1320

ggcguguccc caaccaagcu gaacgaccug ugcuucacca acguguacgc cgauagcuuc     1380

gugaucagag gcgaugaggu gcgccagauc gcuccuggac agaccggaaa gaucgcugac     1440

uacaauuaca agcugcccga cgacuucacc ggcugcguga ucgccuggaa cagcaacaac     1500

cuggauucca aagugggcgg caacuacaac uaucuguacc ggcucuucag aaagucuaac     1560

cugaagcccu uugagagaga caucuccaca gaaaucuacc aggccggaag cacaccuugc     1620

aacggcgugg aaggauuuaa uugcuauuuu ccucugcagu ccuacggcuu ccaaccuacc     1680

aacggagugg gcuaccagcc uuacagagug gucgugcuga gcuuugagcu gcugcaugcc     1740

ccugcuaccg uguguggccc uaagaaaagc acgaaccugg ucaagaacaa augcgugaac     1800

uucaacuuca auggacugac aggcaccggc gugcucacag agagcaacaa gaaguuccug     1860

ccauuucagc aguucggcag agacauagcu gacaccaccg acgccgugcg ggacccccag     1920

acccuggaaa uccuggauau cacacccugc agcuuuggag gcguaucugu gaucacaccu     1980

ggcaccaaca caagcaauca ggucgccgug cuguaccaag acgugaacug cacagaggug     2040

ccgguggcca uccacgccga ucagcugacc cccaccuggc ggguguacuc caccggcagc     2100

aacguguucc aaacccgggc cggcugccug aucggcgccg aacaugugaa uaacagcuac     2160

gaaugugaua ucccuauugg agccggaauu ugcgccagcu accaaaccca aaccaacucu     2220

ccaagaagag ccagaagcgu ggcuagccag ucuaucaucg ccuacaccau gagccugggc     2280

gcugaaaaca gcguggcuua cagcaacaac agcaucgcca uuccuacuaa cuuuaccauc     2340

agcgugacua cagagauccu gcccgugagc augaccaaga ccagcgugga cugcaccaug     2400

uacaucugug gcgauucuac cgagugcagc aacuugcuac ugcaguaugg uagcuuuugc     2460

acccaacuga acagagcccu gacuggcauc gccguugagc aggacaagaa cacccaggag     2520

guguucgccc aggucaagca gaucuauaag accccaccaa ucaaggacuu cggcggcuuc     2580

aacuucagcc agauccugcc cgacccgagc aaaccuagca agagaagcuu caucgaggau     2640

cuucuguuca acaaggugac gcuggccgau gccggcuuca ucaaacagua cggcgauugu     2700

cugggcgaca ucgccgccag agaucugauc ugcgcccaga aguucaaugg ccugaccgug     2760

cugccgccuc ugcucacaga cgagaugauc gcccaguaca ccucugcccu guuagcaggc     2820

acaaucacga gcggcuggac auuuggcgcg ggcgccgcuc ugcagauccc uuucgcuaug     2880

cagauggccu auagauuuaa uggcaucggc gugacccaga augugcugua cgagaaccaa     2940

aagcugaucg cuaaucaguu caauagcgcc aucggaaaga uccaggacuc ucugagcagc     3000

accgccuccg cucugggcaa acugcaggac guggucaauc aaaacgcuca ggcucuaaac     3060

acccugguga agcagcuguc aagcaacuuc ggcgccaucu ccucaguucu uaacgacauc     3120

uugucuagac uggacaaggu ggaggcugag gugcagaucg auagacugau cacaggcaga     3180

uuacagucuc ugcagacaua cgugacccaa cagcugaucc gggccgccga gaucagagcc     3240

uccgccaacc uggcugccac caagaugagc gagugugugc uuggccaguc caagagagug     3300

gacuucugcg gcaaaggcua ccaccugaug agcuucccac agagcgcucc ucacggaguu     3360

guguuccugc acgugaccua cgugccugcc caggagaaga auuucacaac cgccccugcc     3420

aucugccacg acgguaaggc ccacuucccc agagagggcg uguucguguc uaaugggacc     3480

cacugguucg ugacacagag gaacuucuac gagccccaga ucaucacaac agauaauacc     3540

uucgugucug gcaacugcga uguggugauc ggcaucguga acaauaccgu guacgacccu     3600

cugcagcccg agcuggacag cuucaaagag gaacuggaca aguacuucaa gaaucacacc     3660

uccccugacg uggaccuggg agauaucucc ggcaucaacg ccuccguugu gaacauucaa     3720

aaagaaaucg acagacugaa cgagguggcc aagaaccuaa acgagucucu gaucgaccug     3780

caagaacugg gcaaguacga gcaguacauc aaguggccuu gguacaucug gcugggcuuu     3840

aucgccggcc ugaucgccau ugugauggug accaucaugc ugugcugcau gacaaguugc     3900

ugcagcugcc ugaagggcug uuguucuugu ggcagcugcu guaaauucga cgaggacgau     3960

agcgaaccag ugcugaaagg cgucaagcug cauuacaccu ga                        4002


<210>  41
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding CD74 vytoplasmic domain and transmembrane domain with the extracellular domain of spike
      
<400>  41
gccgccacca tggcacacag gaggagaagc aggagctgcc gggaagacca gaagccagtc       60

atggacgacc agcgcgacct catctccaac aacgagcaac tgcccatgct gggccggcgc      120

ccaggggccc cggagagcaa gtgcagccgc ggagccctgt acacaggctt ctccatcctg      180

gtgaccctgc tcctcgccgg ccaggccacc accgcctact tcctgtacgt gaacctgacc      240

acccggaccc agctaccacc agcctacaca aacagcttca cccgcggcgt gtactaccca      300

gacaaggtgt tccggagctc agtgctccac agcacacagg acctgttcct gccattcttc      360

agcaacgtga cgtggttcca cgccatccac gtgtccggca ccaacggaac aaaaaggttc      420

gacaaccccg tgctcccctt caacgacggc gtgtacttcg ccagcacaga aaagtccaaa      480

atcatccgag gatggatctt cggcacaacg ctggactcaa agacccagag cctgctgatc      540

gtgaacaacg ccaccaacgt ggtgatcaag gtgtgcgagt tccagttctg caacgatcca      600

ttcctgggcg tatactacca caagaacaac aagagctgga tggaaagcga gttcagagtg      660

tactcaagcg ccaacaactg caccttcgaa tacgtcagcc agccattcct gatggacctg      720

gaaggcaagc agggcaactt caagaacctg agagagttcg tgttcaagaa catcgacggc      780

tacttcaaga tctacagcaa gcacacaccc atcaacctgg tgcgggacct accgcaggga      840

ttctccgcgc tggaacccct ggtggacctg ccaataggca tcaacatcac cagattccag      900

accctgctgg ccctgcacag aagctacctg acaccaggcg acagcagcag cggctggacc      960

gccggcgccg ccgcatacta cgtggggtac ctgcagccca gaaccttcct gctgaaatac     1020

aacgagaacg gaaccatcac cgacgccgtg gactgcgccc tggaccccct gagcgaaacc     1080

aagtgcaccc tgaaaagctt cacagtggaa aagggaatat accagacctc caacttcaga     1140

gtccagccaa ccgaaagcat cgtgcggttc ccaaacatca ccaacctgtg cccattcggc     1200

gaggtattca acgccacacg gttcgccagc gtatacgcct ggaaccggaa gcggatcagc     1260

aactgcgtgg cagactacag cgtgctatac aacagcgcca gcttaagcac cttcaagtgc     1320

tacggcgtgt ccccaaccaa gctgaacgac ctgtgcttca ccaacgtgta cgccgacagc     1380

ttcgtgatca gaggcgacga ggtgcgccag atcgcaccag gacagaccgg aaagatcgca     1440

gactacaact acaagctgcc cgacgacttc accggctgcg tgatcgcctg gaacagcaac     1500

aacctggact ccaaagtggg cggcaactac aactacctgt accggctctt cagaaagagc     1560

aacctgaagc ccttcgagag agacatcagc acagaaatct accaggccgg aagcacacca     1620

tgcaacggcg tggaaggatt caactgctat ttcccactgc agtcctacgg cttccaacca     1680

accaacggag tgggctacca gccatacaga gtggtcgtgc tgagcttcga gctgctgcac     1740

gccccagcaa ccgtgtgcgg cccaaagaaa agcacgaacc tggtcaagaa caaatgcgtg     1800

aacttcaact tcaacggact gacaggcacc ggcgtgctca cagagagcaa caagaagttc     1860

ctgccattcc agcagttcgg cagagacata gcagacacca ccgacgccgt gcgggacccc     1920

cagaccctgg aaatcctgga catcacaccc tgcagcttcg gaggcgtaag cgtgatcaca     1980

ccaggcacca acacaagcaa ccaggtcgcc gtgctgtacc aagacgtgaa ctgcacagag     2040

gtgccggtgg ccatccacgc cgaccagctg acccccacct ggcgggtgta ctccaccggc     2100

agcaacgtgt tccaaacccg ggccggctgc ctgatcggcg ccgaacacgt gaacaacagc     2160

tacgaatgcg acatcccaat cggagccgga atctgcgcca gctaccaaac ccaaaccaac     2220

agcccaagaa gagccagaag cgtggcaagc cagagcatca tcgcctacac catgagcctg     2280

ggcgcagaaa acagcgtggc atacagcaac aacagcatcg ccatcccaac caacttcacc     2340

atcagcgtga ccacagagat cctgcccgtg agcatgacca agaccagcgt ggactgcacc     2400

atgtacatct gcggcgacag caccgagtgc agcaacttgc tactgcagta cggaagcttc     2460

tgcacccaac tgaacagagc cctgaccggc atcgccgtcg agcaggacaa gaacacccag     2520

gaggtgttcg cccaggtcaa gcagatctac aagaccccac caatcaagga cttcggcggc     2580

ttcaacttca gccagatcct gcccgacccg agcaaaccaa gcaagagaag cttcatcgag     2640

gacctactgt tcaacaaggt gacgctggcc gacgccggct tcatcaaaca gtacggcgac     2700

tgcctgggcg acatcgccgc cagagacctg atctgcgccc agaagttcaa tggcctgacc     2760

gtgctgccgc cactgctcac agacgagatg atcgcccagt acaccagcgc cctgttagca     2820

ggcacaatca cgagcggctg gacattcggc gcgggcgccg cactgcagat cccattcgca     2880

atgcagatgg cctacagatt caatggcatc ggcgtgaccc agaacgtgct gtacgagaac     2940

caaaagctga tcgcaaacca gttcaacagc gccatcggaa agatccagga cagcctgagc     3000

agcaccgcct ccgcactggg caaactgcag gacgtggtca accaaaacgc acaggcacta     3060

aacaccctgg tgaagcagct gtcaagcaac ttcggcgcca tcagctcagt cctaaacgac     3120

atcttgagca gactggacaa ggtggaggca gaggtgcaga tcgacagact gatcacaggc     3180

agattacaga gcctgcagac atacgtgacc caacagctga tccgggccgc cgagatcaga     3240

gcctccgcca acctggcagc caccaagatg agcgagtgcg tgctaggcca gagcaagaga     3300

gtggacttct gcggcaaagg ctaccacctg atgagcttcc cacagagcgc accacacgga     3360

gtagtgttcc tgcacgtgac ctacgtgcca gcccaggaga agaacttcac aaccgcccca     3420

gccatctgcc acgacggaaa ggcccacttc cccagagagg gcgtgttcgt gagcaacggg     3480

acccactggt tcgtgacaca gaggaacttc tacgagcccc agatcatcac aacagacaac     3540

accttcgtga gcggcaactg cgacgtggtg atcggcatcg tgaacaacac cgtgtacgac     3600

ccactgcagc ccgagctgga cagcttcaaa gaggaactgg acaagtactt caagaaccac     3660

acctccccag acgtggacct gggagacatc agcggcatca acgcctccgt agtgaacatc     3720

caaaaagaaa tcgacagact gaacgaggtg gccaagaacc taaacgagag cctgatcgac     3780

ctgcaagaac tgggcaagta cgagcagtac atcaagtggc cataa                     3825


<210>  42
<211>  3981
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding CD74 cytoplasmic domain and transmembrane domain with full length spike 
       (without furin cleavage site)

<400>  42
gccgccacca ugcacaggag gagaagcagg agcugucggg aagaucagaa gccagucaug       60

gaugaccagc gcgaccuuau cuccaacaau gagcaacugc ccaugcuggg ccggcgcccu      120

ggggccccgg agagcaagug cagccgcgga gcccuguaca caggcuuuuc cauccuggug      180

acucugcucc ucgcuggcca ggccaccacc gccuacuucc uguacgugaa ccugaccacc      240

cggacccagc uaccuccugc cuacacaaac agcuucaccc gcggcgugua cuacccugau      300

aagguguucc ggagcucugu gcuccacagc acacaggacc uguuccugcc uuucuucagc      360

aacgugacgu gguuccacgc cauccacgug uccggcacca augguacaaa aagguuugac      420

aaccccgugc uccccuucaa cgacggcgug uauuuugcca gcacugaaaa guccaauauc      480

auccgaggau ggaucuucgg cacaacgcug gacucuaaga cccagagccu gcugaucgug      540

aacaacgcca ccaacguggu gaucaaggug ugcgaguuuc aguucugcaa cgauccuuuu      600

cugggcguuu acuaccacaa gaacaacaag agcuggaugg aaagcgaguu cagaguguau      660

ucuagcgcca acaacuguac cuucgaauac gucagccagc cuuuccugau ggaccuggaa      720

ggcaagcagg gcaacuucaa gaaccugaga gaguucgugu ucaagaacau cgacggcuac      780

uucaagaucu acagcaagca cacaccuauc aaccuggugc gggaccuucc gcagggauuc      840

uccgcgcugg aaccccuggu ggaccugccu auuggcauca acaucaccag auuucagacc      900

cugcuggccc ugcacagaag cuaccugaca ccuggcgacu cuucuagcgg cuggaccgcc      960

ggcgccgccg cuuauuacgu gggguaccug cagcccagaa ccuuccugcu gaaauacaau     1020

gagaacggaa ccaucaccga ugccguggac ugcgcccugg acccccuguc ugaaaccaag     1080

ugcacccuga aaucuuuuac aguggaaaag ggaauuuacc agaccuccaa cuuuagaguc     1140

cagccuaccg aaagcaucgu gcgguucccu aacaucacca accugugucc uuucggcgag     1200

guuuucaacg ccacacgguu cgccagcgua uacgccugga accggaagcg gaucucuaac     1260

uguguggcag acuacucugu gcuauacaac ucggccagcu uuagcaccuu caagugcuac     1320

ggcguguccc caaccaagcu gaacgaccug ugcuucacca acguguacgc cgauagcuuc     1380

gugaucagag gcgaugaggu gcgccagauc gcuccuggac agaccggaaa gaucgcugac     1440

uacaauuaca agcugcccga cgacuucacc ggcugcguga ucgccuggaa cagcaacaac     1500

cuggauucca aagugggcgg caacuacaac uaucuguacc ggcucuucag aaagucuaac     1560

cugaagcccu uugagagaga caucuccaca gaaaucuacc aggccggaag cacaccuugc     1620

aacggcgugg aaggauuuaa uugcuauuuu ccucugcagu ccuacggcuu ccaaccuacc     1680

aacggagugg gcuaccagcc uuacagagug gucgugcuga gcuuugagcu gcugcaugcc     1740

ccugcuaccg uguguggccc uaagaaaagc acgaaccugg ucaagaacaa augcgugaac     1800

uucaacuuca auggacugac aggcaccggc gugcucacag agagcaacaa gaaguuccug     1860

ccauuucagc aguucggcag agacauagcu gacaccaccg acgccgugcg ggacccccag     1920

acccuggaaa uccuggauau cacacccugc agcuuuggag gcguaucugu gaucacaccu     1980

ggcaccaaca caagcaauca ggucgccgug cuguaccaag acgugaacug cacagaggug     2040

ccgguggcca uccacgccga ucagcugacc cccaccuggc ggguguacuc caccggcagc     2100

aacguguucc aaacccgggc cggcugccug aucggcgccg aacaugugaa uaacagcuac     2160

gaaugugaua ucccuauugg agccggaauu ugcgccagcu accaaaccca aaccaacucu     2220

gcuagccagu cuaucaucgc cuacaccaug agccugggcg cugaaaacag cguggcuuac     2280

agcaacaaca gcaucgccau uccuacuaac uuuaccauca gcgugacuac agagauccug     2340

cccgugagca ugaccaagac cagcguggac ugcaccaugu acaucugugg cgauucuacc     2400

gagugcagca acuugcuacu gcaguauggu agcuuuugca cccaacugaa cagagcccug     2460

acuggcaucg ccguugagca ggacaagaac acccaggagg uguucgccca ggucaagcag     2520

aucuauaaga ccccaccaau caaggacuuc ggcggcuuca acuucagcca gauccugccc     2580

gacccgagca aaccuagcaa gagaagcuuc aucgaggauc uucuguucaa caaggugacg     2640

cuggccgaug ccggcuucau caaacaguac ggcgauuguc ugggcgacau cgccgccaga     2700

gaucugaucu gcgcccagaa guucaauggc cugaccgugc ugccgccucu gcucacagac     2760

gagaugaucg cccaguacac cucugcccug uuagcaggca caaucacgag cggcuggaca     2820

uuuggcgcgg gcgccgcucu gcagaucccu uucgcuaugc agauggccua uagauuuaau     2880

ggcaucggcg ugacccagaa ugugcuguac gagaaccaaa agcugaucgc uaaucaguuc     2940

aauagcgcca ucggaaagau ccaggacucu cugagcagca ccgccuccgc ucugggcaaa     3000

cugcaggacg uggucaauca aaacgcucag gcucuaaaca cccuggugaa gcagcuguca     3060

agcaacuucg gcgccaucuc cucaguucuu aacgacaucu ugucuagacu ggacaaggug     3120

gaggcugagg ugcagaucga uagacugauc acaggcagau uacagucucu gcagacauac     3180

gugacccaac agcugauccg ggccgccgag aucagagccu ccgccaaccu ggcugccacc     3240

aagaugagcg agugugugcu uggccagucc aagagagugg acuucugcgg caaaggcuac     3300

caccugauga gcuucccaca gagcgcuccu cacggaguug uguuccugca cgugaccuac     3360

gugccugccc aggagaagaa uuucacaacc gccccugcca ucugccacga cgguaaggcc     3420

cacuucccca gagagggcgu guucgugucu aaugggaccc acugguucgu gacacagagg     3480

aacuucuacg agccccagau caucacaaca gauaauaccu ucgugucugg caacugcgau     3540

guggugaucg gcaucgugaa caauaccgug uacgacccuc ugcagcccga gcuggacagc     3600

uucaaagagg aacuggacaa guacuucaag aaucacaccu ccccugacgu ggaccuggga     3660

gauaucuccg gcaucaacgc cuccguugug aacauucaaa aagaaaucga cagacugaac     3720

gagguggcca agaaccuaaa cgagucucug aucgaccugc aagaacuggg caaguacgag     3780

caguacauca aguggccuug guacaucugg cugggcuuua ucgccggccu gaucgccauu     3840

gugaugguga ccaucaugcu gugcugcaug acaaguugcu gcagcugccu gaagggcugu     3900

uguucuugug gcagcugcug uaaauucgac gaggacgaua gcgaaccagu gcugaaaggc     3960

gucaagcugc auuacaccug a                                               3981


<210>  43
<211>  3840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a Spike S1+S2 ECD_CD74+HLA

<400>  43
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtga acctcactac gcgaactcaa      240

ctgccgcctg cttacactaa tagttttaca cgaggagtct actacccgga caaggtgttc      300

cgctcaagtg tcttgcacag cacgcaagac ctgttcttgc catttttcag caatgtaacg      360

tggtttcatg ccatccacgt gtcaggtact aacggaacga agagatttga taacccggtc      420

ctcccgttca acgacggggt ttattttgcc agtacagaaa agtccaatat tataagggga      480

tggattttcg gcacgactct cgactctaag acacaaagct tgctcatcgt taataatgct      540

acaaacgtgg ttataaaagt atgcgagttc caattctgta acgacccctt tctgggggtt      600

tactaccaca aaaataataa gagttggatg gagagcgaat tcagagttta ctcttccgcg      660

aataattgca ccttcgagta cgtatcccag ccttttctta tggatcttga ggggaaacaa      720

ggtaatttca aaaaccttag agaattcgtt tttaagaata tagatggata cttcaagatt      780

tattctaaac ataccccaat caatctggtg cgcgatcttc ctcagggttt ctctgcgctg      840

gagcctctcg ttgatctgcc gatcggaatt aatataacca gattccagac ccttttggca      900

ttgcaccgct cctatctgac acctggggat agtagttccg gctggacagc gggcgccgcg      960

gcatactacg ttggatatct ccaaccccgc acttttcttc tgaaatataa tgagaatgga     1020

acgattacag acgcagtaga ttgcgcgctt gacccccttt cagaaacaaa gtgcacgctg     1080

aaatctttca cggtcgagaa gggcatttac caaacgtcca atttcagagt tcaacccact     1140

gagtctatag tcaggtttcc gaacatcacc aatctctgcc catttggaga ggttttcaac     1200

gcaacacggt tcgcctctgt atacgcatgg aatagaaaga gaatatccaa ttgtgtcgca     1260

gactatagtg tcttgtacaa ctctgcgtca tttagcactt ttaaatgtta tggggtgagt     1320

ccaactaaat tgaacgatct ctgctttaca aatgtttacg cagatagttt tgtgatacga     1380

ggcgacgagg tacgacaaat tgctcctggc cagaccggga aaatagcgga ctacaattat     1440

aaactgccag acgatttcac cggctgtgtg atcgcgtgga actcaaacaa cttggatagt     1500

aaggtaggtg gtaactataa ctacttgtac cggctcttcc gcaaaagtaa tcttaaaccg     1560

ttcgagcggg acatctctac cgagatctat caagcaggta gcactccctg caatggagtc     1620

gagggtttta attgctattt tcccctccaa tcatacgggt ttcagcccac aaatggtgtt     1680

gggtatcagc cctatcgagt tgtggtgctt tcatttgaat tgcttcatgc accggcgaca     1740

gtttgtggtc ctaaaaagag taccaatttg gttaaaaaca aatgtgtcaa ctttaacttt     1800

aacggtctga ctggtacggg ggtgcttacg gaatctaata aaaagtttct tccgttccag     1860

caattcggac gggacatagc ggacacgact gacgcggtta gagacccaca aacactcgag     1920

attcttgaca taaccccctg ttctttcggc ggagtttctg taataacgcc tgggacaaat     1980

acgtcaaacc aggttgcagt attgtaccag gatgtcaact gcactgaagt gccagtcgcg     2040

atccacgcag atcagttgac tccaacatgg agggtctact ctaccggttc taacgtgttt     2100

cagaccagag ccgggtgcct cattggcgcg gaacatgtga acaattctta cgaatgcgac     2160

atacccatcg gcgccggcat ttgtgcgtca taccaaactc aaactaattc ccggagtgtg     2220

gcctcccaat ctattattgc ttatactatg agtcttggcg cggaaaacag tgtagcgtac     2280

tcaaataact ctattgcgat ccccacgaat ttcactataa gcgtaactac tgaaattttg     2340

ccggtaagca tgacgaaaac ttcagtggac tgcacaatgt acatttgtgg tgacagcact     2400

gagtgctcaa atctcctcct tcagtatggt tctttctgca cacaacttaa cagggcactt     2460

accggaatcg cagtagaaca agacaaaaac acgcaagaag tattcgcaca ggtcaaacaa     2520

atttataaaa ccccgccgat caaggatttt ggagggttta acttcagtca gatccttcca     2580

gacccatcca aacccagcaa acggagcttt attgaagacc tgctgtttaa taaagttacc     2640

cttgcagatg ccggtttcat caagcaatac ggggattgtc tgggcgacat tgccgcccgc     2700

gacttgatct gtgcccagaa gttcaacggt ctcacagtct tgccgccact tctcactgat     2760

gaaatgatag cgcagtatac atccgcgctg ctggctggga cgataacatc tggttggact     2820

ttcggggccg gggcggcttt gcaaattcct ttcgccatgc agatggccta taggtttaac     2880

ggcataggag tgactcaaaa tgttctttat gagaatcaga agcttatcgc caaccaattt     2940

aactccgcga ttgggaagat acaggactca ttgagctcta ctgctagcgc ccttggcaag     3000

cttcaagacg tagtcaacca aaatgctcaa gcgctcaata ctctcgtaaa gcagctctca     3060

agcaactttg gcgcgatatc ttcagttttg aacgacatct tgagcagact cgacaaggtg     3120

gaggctgaag ttcaaattga tcgactgatt acgggccggc tccagtcact ccaaacgtac     3180

gtgacccaac aactcattag agcggcagag attagagcga gcgctaatct ggcggccaca     3240

aagatgtcag aatgtgtgct tggtcaatcc aaaagggtgg atttctgcgg aaagggctat     3300

cacttgatga gtttcccgca gtccgcgcct catggagttg ttttcctcca cgtaacctac     3360

gttcccgctc aggaaaagaa tttcacgaca gctccggcaa tatgtcatga cggtaaagca     3420

catttcccca gggaaggcgt ttttgtcagt aatggaaccc actggttcgt cacccagcga     3480

aacttttacg agccccaaat aataactact gacaatacct tcgtcagcgg caattgcgac     3540

gtcgtcatag gcatagtaaa taatacggtt tacgaccctc ttcaacccga gttggacagc     3600

ttcaaagaag aacttgataa gtattttaaa aaccacacta gcccagatgt agaccttggc     3660

gacatcagcg gtatcaatgc ttccgttgtg aacattcaaa aggaaattga ccgactcaat     3720

gaagtagcga agaacttgaa tgagtctctg atcgatcttc aggagctcgg gaaatatgag     3780

caatacatca aatggccgtc acgactggag gaagaactgc gccgacgcct gactgaatga     3840


<210>  44
<211>  1277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spike S1+S2 ECD_CD74+HLA

<400>  44

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
        115                 120                 125             


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
    130                 135                 140                 


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
145                 150                 155                 160 


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
                165                 170                 175     


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
            180                 185                 190         


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
        195                 200                 205             


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
    210                 215                 220                 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
225                 230                 235                 240 


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
                245                 250                 255     


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
            260                 265                 270         


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
        275                 280                 285             


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
305                 310                 315                 320 


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
                325                 330                 335     


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
            340                 345                 350         


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
        355                 360                 365             


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
    370                 375                 380                 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
385                 390                 395                 400 


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
                405                 410                 415     


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
            420                 425                 430         


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
        435                 440                 445             


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
    450                 455                 460                 


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
465                 470                 475                 480 


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
                485                 490                 495     


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
            500                 505                 510         


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
        515                 520                 525             


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
    530                 535                 540                 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
545                 550                 555                 560 


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
                565                 570                 575     


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
            580                 585                 590         


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
        595                 600                 605             


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
    610                 615                 620                 


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
625                 630                 635                 640 


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
                645                 650                 655     


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys 
            660                 665                 670         


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
        675                 680                 685             


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
    690                 695                 700                 


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
705                 710                 715                 720 


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg 
                725                 730                 735     


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
            740                 745                 750         


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
        755                 760                 765             


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
    770                 775                 780                 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
785                 790                 795                 800 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
                805                 810                 815     


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
            820                 825                 830         


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
        835                 840                 845             


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
    850                 855                 860                 


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
865                 870                 875                 880 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
                885                 890                 895     


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
            900                 905                 910         


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
        915                 920                 925             


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
    930                 935                 940                 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
945                 950                 955                 960 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
                965                 970                 975     


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
            980                 985                 990         


Ala Ser Ala Leu Gly Lys Leu Gln  Asp Val Val Asn Gln  Asn Ala Gln 
        995                 1000                 1005             


Ala Leu  Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
    1010                 1015                 1020             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1025                 1030                 1035             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1040                 1045                 1050             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1055                 1060                 1065             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1070                 1075                 1080             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1085                 1090                 1095             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1100                 1105                 1110             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1115                 1120                 1125             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1130                 1135                 1140             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1145                 1150                 1155             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1160                 1165                 1170             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1175                 1180                 1185             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1190                 1195                 1200             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1205                 1210                 1215             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1220                 1225                 1230             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1235                 1240                 1245             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1250                 1255                 1260             


Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1265                 1270                 1275         


<210>  45
<211>  3834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Kent spike S1+S2 ECD_CD74+HLA

<400>  45
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtta acctgacaac acgcacccag      240

ttgccaccgg cctatacgaa ctctttcacg cgcggagtgt attatcccga taaagtcttt      300

cggagttctg tgctgcactc tacacaagat ctttttctgc cctttttctc caacgttacg      360

tggttccatg caataagtgg tacgaatggt actaaaaggt tcgataatcc cgtacttccc      420

ttcaatgacg gcgtgtattt cgcgagcaca gaaaagagca acataataag aggttggatt      480

tttgggacta ccctggactc taaaacacaa agcctcctca ttgttaataa cgcaactaat      540

gtcgtaataa aggtatgcga atttcagttt tgtaacgacc cttttttggg agtctatcat      600

aagaacaata agtcctggat ggaaagtgaa tttagggtgt atagttcagc gaacaactgt      660

acatttgagt atgtgtcaca gccgttcctt atggatcttg aagggaaaca ggggaacttc      720

aagaacctgc gggaattcgt gtttaaaaat atagacggtt attttaaaat ctatagcaaa      780

cacaccccaa taaacctggt tcgggatctt cctcagggat tttcagcttt ggaaccgttg      840

gttgacctcc ccatcgggat aaatatcacg cgatttcaaa cactgctggc actgcaccgg      900

agttatctga ctcctggaga tagcagctcc ggctggacgg ctggcgccgc ggcttattat      960

gtcgggtacc ttcaaccgcg aacgtttctt ttgaagtata acgaaaatgg cactataacc     1020

gatgcagtag attgtgcgtt ggaccctctt tccgagacta agtgcaccct gaagtcattt     1080

acagtagaga aggggatata ccagacaagc aacttccgcg tccaaccaac ggaaagcatc     1140

gtgcgctttc ccaatattac taacctctgt ccgttcggcg aggtttttaa tgctaccaga     1200

tttgcctcag tgtatgcctg gaaccgcaag aggattagca actgcgttgc tgactatagc     1260

gtgctttaca attccgccag ttttagtacg ttcaagtgtt atggggtaag ccctaccaag     1320

cttaacgatc tttgcttcac gaatgtttac gcagactcat tcgtaatacg aggtgatgaa     1380

gtgcgacaga tagccccggg tcagacgggg aaaatagccg actacaatta caagctcccg     1440

gacgacttca cgggctgtgt tattgcgtgg aacagcaata acctggacag taaagttgga     1500

gggaattata actacttgta caggctgttc cgcaaatcta atttgaaacc gtttgaaagg     1560

gacatttcca ccgagattta ccaagccggc agtaccccat gtaacggagt tgagggattt     1620

aattgctact ttccgctcca atcatatgga ttccagccta catacggcgt cggatatcaa     1680

ccttataggg tggtcgttct ttcttttgag ctgcttcacg ccccagcaac cgtttgcggc     1740

ccgaaaaaat caacgaactt ggtcaaaaac aagtgcgtca acttcaattt caacggactg     1800

acaggcaccg gagtgctcac cgagtcaaat aaaaaattcc tcccgtttca acaattcggt     1860

agagatatag acgacaccac agatgcggta cgcgaccctc agactcttga aattttggac     1920

attacaccat gttccttcgg tggcgtctca gtgattacgc ctggcactaa cactagcaac     1980

caagtcgcag tactttatca gggcgttaac tgtacagaag taccagttgc gatacacgcg     2040

gaccagctca ccccaacctg gcgcgtatat tctaccggat ctaatgtgtt tcaaacgcgg     2100

gcggggtgcc tcataggtgc agagcatgtc aataactcct acgaatgtga cattcctata     2160

ggagcaggaa tatgtgcgag ctaccagact caaaccaatt cacacaggag cgtagctagt     2220

cagtccataa ttgcctacac tatgtcactt ggtgctgaaa acagtgtggc ttattcaaat     2280

aattccatag ctattccaat caatttcact attagcgtaa caactgagat acttccagtc     2340

agcatgacta agacttcagt tgattgtacg atgtatattt gtggcgattc tacagaatgt     2400

agtaaccttc tgttgcaata cggctccttt tgcacacagc tcaatcgcgc attgacgggt     2460

atagctgtag agcaagataa aaacacccaa gaagtcttcg cgcaggtgaa gcaaatatat     2520

aagacaccac cgattaaaga tttcggtgga ttcaatttta gccaaattct gcctgatcca     2580

agcaaaccgt caaaaagatc cttcatagag gacctgcttt tcaataaggt aacgctggcg     2640

gacgcagggt ttattaaaca atacggcgat tgccttggtg acattgctgc acgagacctc     2700

atttgcgccc agaagttcaa cggactcaca gtactgcctc cactgctcac agacgagatg     2760

atcgcccagt acacatctgc cttgttggct ggtacgataa cttctggttg gacctttgga     2820

gcgggagcag cacttcagat tccctttgcc atgcagatgg cgtacagatt caacggcatt     2880

ggtgtcacgc agaacgtact gtatgagaac cagaagttga tagctaatca attcaactcc     2940

gcgataggta agatccaaga cagtctctcc tcaacagcct ccgcactcgg gaaactccag     3000

gatgtggtaa atcagaatgc acaggcattg aatacgcttg ttaaacaatt gtcctcaaat     3060

tttggcgcca tatcatcagt gctcaacgac atccttgcca gactcgataa agtggaggca     3120

gaagtgcaga tagatcgctt gattactggg cgcctccaat ctctccaaac gtacgtgaca     3180

caacagctta ttcgggcagc ggaaatccgc gcctctgcga accttgcagc gaccaagatg     3240

agcgaatgtg ttctcgggca gtcaaaacga gtagatttct gcggtaaagg atatcatctt     3300

atgtcattcc cccaaagcgc tccacatggt gttgtatttc tgcacgtgac ttacgtgccg     3360

gcacaggaga agaatttcac aacggctccc gccatctgtc acgacggaaa ggcacacttc     3420

cctagggagg gggtgtttgt aagcaatggt acccactggt ttgtcacaca acgaaacttc     3480

tatgaacctc agataattac aacgcataat acttttgtaa gtgggaactg cgacgtcgtt     3540

atcggaatag ttaacaatac tgtatatgat ccgttgcagc cggagttgga ctcatttaaa     3600

gaagagctgg acaagtactt caaaaaccat acaagcccag atgtagatct tggggacata     3660

agtgggataa acgccagcgt tgtgaacata cagaaggaaa tagacaggct gaatgaggta     3720

gcaaagaatc ttaacgaaag ccttatagat cttcaggaac ttgggaagta cgaacagtac     3780

ataaagtggc cttcacgact ggaggaagaa ctgcgccgac gcctgactga atga           3834


<210>  46
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kent spike S1+S2 ECD_CD74+HLA

<400>  46

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly 
        115                 120                 125             


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
    130                 135                 140                 


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
145                 150                 155                 160 


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
                165                 170                 175     


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
            180                 185                 190         


Phe Leu Gly Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
        195                 200                 205             


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
    210                 215                 220                 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
225                 230                 235                 240 


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
                245                 250                 255     


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
            260                 265                 270         


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
        275                 280                 285             


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
    290                 295                 300                 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
305                 310                 315                 320 


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
                325                 330                 335     


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
            340                 345                 350         


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
        355                 360                 365             


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
    370                 375                 380                 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
385                 390                 395                 400 


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
                405                 410                 415     


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
            420                 425                 430         


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
        435                 440                 445             


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
    450                 455                 460                 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
465                 470                 475                 480 


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
                485                 490                 495     


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
            500                 505                 510         


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
        515                 520                 525             


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
    530                 535                 540                 


Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr 
545                 550                 555                 560 


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
                565                 570                 575     


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
            580                 585                 590         


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
        595                 600                 605             


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr 
    610                 615                 620                 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
625                 630                 635                 640 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
                645                 650                 655     


Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val 
            660                 665                 670         


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
        675                 680                 685             


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
    690                 695                 700                 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
705                 710                 715                 720 


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser His Arg Ser Val 
                725                 730                 735     


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
            740                 745                 750         


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr 
        755                 760                 765             


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
    770                 775                 780                 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
785                 790                 795                 800 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
                805                 810                 815     


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
            820                 825                 830         


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
        835                 840                 845             


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
    850                 855                 860                 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
865                 870                 875                 880 


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
                885                 890                 895     


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
            900                 905                 910         


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
        915                 920                 925             


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
    930                 935                 940                 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
945                 950                 955                 960 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
                965                 970                 975     


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
            980                 985                 990         


Ala Leu Gly Lys Leu Gln Asp Val  Val Asn Gln Asn Ala  Gln Ala Leu 
        995                 1000                 1005             


Asn Thr  Leu Val Lys Gln Leu  Ser Ser Asn Phe Gly  Ala Ile Ser 
    1010                 1015                 1020             


Ser Val  Leu Asn Asp Ile Leu  Ala Arg Leu Asp Lys  Val Glu Ala 
    1025                 1030                 1035             


Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu 
    1040                 1045                 1050             


Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
    1055                 1060                 1065             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1070                 1075                 1080             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1085                 1090                 1095             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1100                 1105                 1110             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1115                 1120                 1125             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1130                 1135                 1140             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1145                 1150                 1155             


Tyr Glu  Pro Gln Ile Ile Thr  Thr His Asn Thr Phe  Val Ser Gly 
    1160                 1165                 1170             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1175                 1180                 1185             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1190                 1195                 1200             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1205                 1210                 1215             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1220                 1225                 1230             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1235                 1240                 1245             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Ser 
    1250                 1255                 1260             


Arg Leu  Glu Glu Glu Leu Arg  Arg Arg Leu Thr Glu  
    1265                 1270                 1275 


<210>  47
<211>  3840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding South Africa Spike S1+S2 ECD_CD74+HLA

<400>  47
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtca atttcactac acgcacacag      240

ctgcccccgg cgtacactaa cagttttacg aggggagtct actacccgga caaagtgttc      300

aggtcttccg tactccatag cacacaagac ctcttcttgc cttttttcag caatgttacg      360

tggttccatg caatccatgt gagcggtaca aacgggacta aacgctttgc aaatccagtg      420

ttgcccttca acgacggtgt atacttcgcg agtacagaga agagcaacat aatacgcggg      480

tggatatttg gaacgacgct tgattctaag acacagagct tgctcatcgt aaacaacgca      540

acgaatgttg taatcaaggt ctgcgaattc caattctgca atgacccatt tcttggagtt      600

tattaccata agaacaataa gtcttggatg gaatccgagt tccgcgtata ctctagcgcg      660

aacaactgca ccttcgagta tgtgtcccaa ccgtttctga tggatcttga gggaaagcag      720

ggtaatttta aaaatctccg ggagttcgtt ttcaaaaata ttgacggata tttcaaaatc      780

tacagcaagc ataccccaat caatttggtg cggggtctgc cacaaggatt ttccgctctt      840

gaacctcttg ttgaccttcc cataggaatc aatataactc ggttccaaac tcttcttgcg      900

ctccatatat cctacttgac gcccggagat tcatcaagtg gctggacggc tggggctgcc      960

gcatactacg tcggctatct gcaaccaagg acgtttctcc tcaaatacaa tgaaaatggt     1020

acgatcaccg acgctgtgga ctgcgctctc gacccgttgt cagagacgaa gtgcaccttg     1080

aagtccttca ccgtggaaaa gggaatttac cagactagta acttccgggt gcagcccacg     1140

gaatcaattg tgcgatttcc taatatcact aatctctgtc ccttcgggga agtgttcaat     1200

gcgactcgat tcgcttcagt atacgcttgg aatagaaaga gaatctcaaa ttgcgtggct     1260

gactattccg tactgtataa tagtgcgtct tttagcacgt ttaagtgtta tggcgtatcc     1320

ccgacaaagc tcaacgatct ctgcttcacg aatgtctatg ccgactcctt cgtgatacgc     1380

ggtgacgagg tacgacaaat tgcacccggc caaactggaa atattgccga ctacaattat     1440

aagttgccgg acgattttac cggttgcgta atagcgtgga actctaataa cctcgactct     1500

aaggtaggag gcaactacaa ttacttgtac cgactgttca ggaaatccaa cctgaagccc     1560

ttcgaaagag acatcagtac agagatttat caagccgggt ccaccccttg caatggtgtc     1620

aaaggcttca actgctattt tccgttgcag tcttacggtt tccagccgac gtacggtgtg     1680

ggttatcaac cctaccgcgt tgtggtgctg agctttgagc ttctccacgc tccagccact     1740

gtctgcgggc ctaagaaatc cacaaacctc gttaagaata aatgcgtaaa tttcaacttc     1800

aacgggctta ctggcacggg cgtgcttacg gagtccaata agaaattcct gcctttccag     1860

cagttcggcc gcgacatcgc ggacacaaca gatgctgtgc gagacccaca aaccctggag     1920

attctggaca tcacgccttg ctcttttggc ggtgtcagcg taataacgcc aggcaccaac     1980

accagtaatc aggtcgccgt gctttatcag ggtgtgaact gtacggaggt accggttgcc     2040

atacacgcag accaactcac acctacgtgg agagtttaca gcaccgggtc aaacgtattt     2100

cagacccgcg caggctgtct gatcggcgca gagcatgtca ataactcata cgagtgtgat     2160

ataccaatcg gagccggcat ctgtgcgagc tatcaaaccc aaactaattc acgaagcgtg     2220

gccagccagt ccatcattgc ctacacgatg tctttgggag tagagaatag cgtggcatac     2280

tctaacaaca gtatcgctat tcctaccaac ttcacaatat cagttactac agaaatcctc     2340

ccggtgagca tgactaagac atccgtagac tgtacaatgt acatttgtgg ggacagcacg     2400

gagtgttcaa acctgctgtt gcaatacgga agcttctgca cccagctcaa ccgagccctg     2460

accggcattg ccgtagaaca agataagaat acgcaggaag tgttcgccca ggttaagcag     2520

atttacaaga ctccgcctat caaggacttc gggggtttca actttagtca gattttgcct     2580

gacccgtcaa agcctagcaa acgaagtttt atcgaagatt tgttgtttaa caaggtgact     2640

ttggctgatg cgggattcat aaaacaatac ggcgattgcc ttggcgatat tgcggcccga     2700

gatctcattt gcgcgcaaaa gttcaacggt cttaccgtcc ttccgcccct gcttacggac     2760

gagatgatcg cacaatacac ttcagcactg ctggctggta caataaccag tgggtggaca     2820

ttcggggctg gtgcagcgct ccagatcccc tttgcgatgc agatggcgta tagattcaat     2880

ggcatcgggg tcactcagaa cgtgctttat gagaaccaaa agcttattgc aaatcaattt     2940

aactctgcga ttggaaagat tcaagacagc ctctcatcca cagctagtgc gcttggcaag     3000

cttcaggacg tcgtaaacca aaacgcccaa gctctcaaca cactcgttaa acagctttcc     3060

tcaaactttg gggctattag ctctgtgctg aatgatattc ttagcagact cgacaaagtc     3120

gaggctgaag tacaaataga tagactgata acaggtagac ttcagtctct ccaaacctac     3180

gtgacacagc agcttataag agctgctgag atcagagctt ctgcgaacct tgcggcgact     3240

aaaatgtccg agtgtgtact cgggcagtct aaacgcgtcg acttctgtgg caagggttac     3300

catctcatga gttttcccca atcagcgccc catggggtag tttttctgca cgtaacatac     3360

gtcccagccc aagaaaagaa ttttaccacc gcccctgcga tttgtcacga cggaaaagca     3420

cactttccaa gagaaggcgt atttgttagc aatggcaccc attggttcgt cacccagaga     3480

aacttttacg aaccgcagat tatcacgaca gataatacat ttgtatctgg taattgtgac     3540

gtcgtgatcg gcatcgtaaa caacactgtt tacgaccccc tccagccaga gcttgactca     3600

tttaaagagg agctcgacaa atattttaag aaccacacaa gtccagacgt cgacttgggt     3660

gacatttccg gcatcaatgc aagtgtggtc aacatccaaa aggaaattga cagattgaac     3720

gaggttgcta agaaccttaa tgagtcactc attgacctcc aggaactggg aaaatacgaa     3780

cagtatatta agtggccctc acgactggag gaagaactgc gccgacgcct gactgaatga     3840


<210>  48
<211>  1277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  South Africa Spike S1+S2 ECD_CD74+HLA

<400>  48

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Phe Thr Thr Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
        115                 120                 125             


Asn Gly Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly 
    130                 135                 140                 


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
145                 150                 155                 160 


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
                165                 170                 175     


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
            180                 185                 190         


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
        195                 200                 205             


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
    210                 215                 220                 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
225                 230                 235                 240 


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
                245                 250                 255     


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro 
            260                 265                 270         


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
        275                 280                 285             


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Ile Ser Tyr Leu 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
305                 310                 315                 320 


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
                325                 330                 335     


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
            340                 345                 350         


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
        355                 360                 365             


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
    370                 375                 380                 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
385                 390                 395                 400 


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
                405                 410                 415     


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
            420                 425                 430         


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
        435                 440                 445             


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
    450                 455                 460                 


Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu 
465                 470                 475                 480 


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
                485                 490                 495     


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
            500                 505                 510         


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
        515                 520                 525             


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr 
    530                 535                 540                 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr 
545                 550                 555                 560 


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
                565                 570                 575     


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
            580                 585                 590         


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
        595                 600                 605             


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
    610                 615                 620                 


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
625                 630                 635                 640 


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
                645                 650                 655     


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys 
            660                 665                 670         


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
        675                 680                 685             


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
    690                 695                 700                 


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
705                 710                 715                 720 


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg 
                725                 730                 735     


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val 
            740                 745                 750         


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
        755                 760                 765             


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
    770                 775                 780                 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
785                 790                 795                 800 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
                805                 810                 815     


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
            820                 825                 830         


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
        835                 840                 845             


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
    850                 855                 860                 


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
865                 870                 875                 880 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
                885                 890                 895     


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
            900                 905                 910         


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
        915                 920                 925             


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
    930                 935                 940                 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
945                 950                 955                 960 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
                965                 970                 975     


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
            980                 985                 990         


Ala Ser Ala Leu Gly Lys Leu Gln  Asp Val Val Asn Gln  Asn Ala Gln 
        995                 1000                 1005             


Ala Leu  Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
    1010                 1015                 1020             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1025                 1030                 1035             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1040                 1045                 1050             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1055                 1060                 1065             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1070                 1075                 1080             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1085                 1090                 1095             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1100                 1105                 1110             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1115                 1120                 1125             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1130                 1135                 1140             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1145                 1150                 1155             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1160                 1165                 1170             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1175                 1180                 1185             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1190                 1195                 1200             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1205                 1210                 1215             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1220                 1225                 1230             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1235                 1240                 1245             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1250                 1255                 1260             


Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1265                 1270                 1275         


<210>  49
<211>  3837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  California Spike S1+S2 ECD_CD74+HLA

<400>  49
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtaa atttgacaac gcgcacccaa      240

ttgcccccag catatacgaa ctctttcacg aggggcgtat attatccgga taaggtattt      300

cggtcatctg ttctgcacag cacccaggac ctcttccttc cattcttttc aaatgtaact      360

tggttccatg cgatagtatc aggaacgaat gggacaaaaa ggttcgataa tccggtcttg      420

ccgttcaacg atggggtgta cttcgccagt accgaaaagt ctaacattat acgcggttgg      480

atttttggca ctacgcttga ctcaaagaca cagtcactcc tcattgtaaa taatgctact      540

aatgtcgtga tcaaagtttg tgagttccaa ttctgcaacg acccgttcct gggagtgtat      600

tatcacaaaa ataataagtc ctgcatggag tcagagttca gggtttactc aagtgcgaac      660

aattgcacat ttgagtacgt ttctcaacca tttctcatgg atttggaggg gaagcaggga      720

aactttaaaa acctgagaga atttgttttt aagaacattg atgggtattt caagatttat      780

agtaaacaca cccctatcaa cttggttagg gatctccctc aaggtttctc tgctctcgag      840

ccccttgtag atctgccaat aggcatcaat atcacacgct ttcagacact cctcgcactt      900

cataggagct acctgacgcc aggtgactct tcctcaggtt ggacagccgg cgcagccgca      960

tactacgttg gctacctcca accaaggaca tttctgttga aatacaacga aaatgggacc     1020

atcaccgacg cagtcgattg tgctctcgac cctctttccg agactaaatg taccctcaaa     1080

agctttactg ttgagaaggg tatctatcag acatctaact ttcgggtgca acccactgag     1140

tcaattgtgc gattcccaaa tattacgaac ctctgtcctt ttggcgaggt ttttaacgcc     1200

actaggttcg ccagtgtata tgcttggaac cgaaaacgga taagcaattg tgttgctgac     1260

tactccgtcc tctacaatag cgctagtttc tcaacattta agtgttacgg tgtgagccct     1320

acgaaactta acgatttgtg cttcactaac gtctatgccg acagtttcgt aatccgaggc     1380

gatgaggtca ggcaaattgc cccgggccaa acggggaaaa tcgctgatta caattataag     1440

ttgccagatg attttacggg atgtgtcatt gcatggaaca gtaataacct cgattcaaag     1500

gttggcggaa attataatta cagatatcgg ctttttagaa aatctaacct taaaccattt     1560

gagcgggaca taagcacgga gatttaccag gctggtagca ctccgtgcaa cggtgtagaa     1620

ggattcaatt gctattttcc attgcagtct tatggattcc aacccaccaa tggggtaggg     1680

taccaaccat acagggtggt agtccttagc tttgaacttt tgcatgcgcc agctaccgtc     1740

tgcggtccca aaaagagtac gaacttggta aaaaataaat gcgtcaactt taattttaac     1800

ggtctgacgg gaacgggggt tctcaccgag tctaacaaaa agtttttgcc atttcagcag     1860

ttcggacgag atattgccga cactaccgac gccgtgcgcg atccacaaac cttggagata     1920

ctcgacatca caccttgcag cttcggtggt gttagcgtta ttacgccagg aacgaacact     1980

tcaaatcagg tggccgtctt gtatcaagat gttaactgta cagaggtgcc cgtcgcaata     2040

cacgcagatc agctcacccc tacctggaga gtttactcta caggctctaa tgtgttccaa     2100

actagggcag gctgcttgat tggagctgaa cacgtaaaca actcatacga gtgcgatatc     2160

ccgattggtg cgggtatttg cgccagctat cagacgcaga ctaactcacg atcagtggcg     2220

tcacagtcaa taattgcgta tacaatgagt ctcggtgcag agaattccgt cgcatactca     2280

aacaacagca tagcgattcc aactaatttt accattagcg ttacaacgga aatcctcccc     2340

gttagcatga ccaagacctc cgtggattgc acaatgtaca tctgtggaga cagcaccgag     2400

tgctccaatc ttcttcttca atatgggagc ttttgcacac agctgaaccg cgcgctcact     2460

ggcattgcgg tagaacaaga caaaaacacc caagaagtgt ttgcgcaggt caaacagatt     2520

tacaagacac caccaatcaa agacttcggg gggttcaatt tctcccaaat tcttcctgat     2580

ccaagcaaac catctaaaag gtccttcata gaagacctcc tgttcaataa ggtgacactc     2640

gcggacgcag ggtttattaa gcaatatgga gattgtctcg gggatattgc agcgagagat     2700

cttatttgtg ctcaaaagtt taatggcttg actgtcctcc cgcccttgct cacagacgag     2760

atgatagcac aatataccag tgcgctgctt gcgggcacga ttacttccgg atggactttc     2820

ggggcaggag cggcgctcca gattcctttc gcgatgcaaa tggcctaccg atttaacggg     2880

attggcgtca cacaaaacgt tctttacgaa aaccagaaac ttattgccaa ccaattcaat     2940

agtgcaattg gtaaaattca ggattcactc tcctccacgg cgtcagctct cggcaagctc     3000

caagacgtgg ttaaccaaaa tgcgcaggcg cttaacacgc ttgtaaaaca actctcttct     3060

aattttggcg cgattagtag cgttctcaac gatatcttgt cacgcttgga caaagtagaa     3120

gcagaagtcc aaatagaccg gctgatcact ggtcgattgc aatctctgca gacatacgtg     3180

acgcagcagc tcatccgggc agccgagatc cgggcgtccg ctaatctggc cgcaaccaaa     3240

atgagcgagt gtgtccttgg gcaaagcaaa cgcgtggatt tttgcggaaa gggctaccac     3300

ctcatgagtt tcccccaatc tgccccgcac ggtgtcgtct ttttgcatgt aacgtatgtc     3360

ccggcgcagg agaaaaattt cactacagct cccgccatct gtcacgacgg caaggcacac     3420

ttccctcgag aaggggtgtt tgtaagcaat ggaacacact ggttcgtcac ccagcggaat     3480

ttttatgaac ctcagataat cacaacagac aacactttcg tttccggaaa ctgcgatgtc     3540

gtaattggga tagtgaataa taccgtatat gacccattgc agccggagtt ggactccttt     3600

aaagaggaat tggacaaata ctttaaaaat cacacttcac ccgatgtgga cctgggagat     3660

atatccggga ttaacgcaag tgtggttaac atacaaaagg aaattgaccg ccttaacgag     3720

gttgctaaga acttgaatga gtctctcata gatctccagg aactggggaa atacgagcaa     3780

tatatcaaat ggccgtcacg actggaggaa gaactgcgcc gacgcctgac tgaatga        3837


<210>  50
<211>  1276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  California Spike S1+S2 ECD_CD74+HLA

<400>  50

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile Val Ser Gly Thr Asn 
        115                 120                 125             


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
    130                 135                 140                 


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
145                 150                 155                 160 


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
                165                 170                 175     


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
            180                 185                 190         


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Cys Met Glu 
        195                 200                 205             


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
    210                 215                 220                 


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
225                 230                 235                 240 


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
                245                 250                 255     


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
            260                 265                 270         


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
        275                 280                 285             


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
    290                 295                 300                 


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
305                 310                 315                 320 


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
                325                 330                 335     


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
            340                 345                 350         


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
        355                 360                 365             


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
    370                 375                 380                 


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
385                 390                 395                 400 


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
                405                 410                 415     


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
            420                 425                 430         


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
        435                 440                 445             


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
    450                 455                 460                 


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
465                 470                 475                 480 


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
                485                 490                 495     


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys 
            500                 505                 510         


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
        515                 520                 525             


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
    530                 535                 540                 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
545                 550                 555                 560 


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
                565                 570                 575     


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
            580                 585                 590         


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
        595                 600                 605             


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
    610                 615                 620                 


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
625                 630                 635                 640 


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
                645                 650                 655     


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
            660                 665                 670         


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
        675                 680                 685             


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
    690                 695                 700                 


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
705                 710                 715                 720 


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser 
                725                 730                 735     


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
            740                 745                 750         


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
        755                 760                 765             


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
    770                 775                 780                 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
785                 790                 795                 800 


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
                805                 810                 815     


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
            820                 825                 830         


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
        835                 840                 845             


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
    850                 855                 860                 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
865                 870                 875                 880 


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
                885                 890                 895     


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
            900                 905                 910         


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
        915                 920                 925             


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
    930                 935                 940                 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
945                 950                 955                 960 


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
                965                 970                 975     


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
            980                 985                 990         


Ser Ala Leu Gly Lys Leu Gln Asp  Val Val Asn Gln Asn  Ala Gln Ala 
        995                 1000                 1005             


Leu Asn  Thr Leu Val Lys Gln  Leu Ser Ser Asn Phe  Gly Ala Ile 
    1010                 1015                 1020             


Ser Ser  Val Leu Asn Asp Ile  Leu Ser Arg Leu Asp  Lys Val Glu 
    1025                 1030                 1035             


Ala Glu  Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
    1040                 1045                 1050             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1055                 1060                 1065             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1070                 1075                 1080             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1085                 1090                 1095             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1100                 1105                 1110             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1115                 1120                 1125             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1130                 1135                 1140             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1145                 1150                 1155             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1160                 1165                 1170             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1175                 1180                 1185             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1190                 1195                 1200             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1205                 1210                 1215             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1220                 1225                 1230             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1235                 1240                 1245             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro 
    1250                 1255                 1260             


Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg Leu Thr  Glu 
    1265                 1270                 1275     


<210>  51
<211>  3840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Brazil Spike S1+S2 ECD_CD74+HLA

<400>  51
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtta actttactaa tcggacccaa      240

ctcccgagtg cgtacactaa ctcttttacc cggggcgtct attatcctga caaagtgttt      300

cgatcatctg ttttgcactc cacccaagat ctctttcttc catttttcag caacgttacg      360

tggttccacg cgatacatgt tagtggtact aatggcacaa agagatttga caaccctgtg      420

ctcccgttta acgatggggt ctatttcgct tccactgaga agtccaacat tattcgcggt      480

tggatcttcg gcaccacact cgattcaaaa acccaaagct tgctcatagt taacaacgcc      540

acaaacgtag tcattaaagt gtgcgaattt cagttttgta actatccctt tttgggcgtc      600

tactatcaca agaacaacaa gtcctggatg gaatctgagt ttcgggtcta cagttcagcc      660

aacaactgta cgtttgagta cgttagccag ccctttctga tggatcttga agggaagcaa      720

ggaaatttca agaatctttc cgagtttgtg tttaaaaata tagacggata tttcaagata      780

tacagtaagc acacaccgat caatttggta cgggatttgc cgcaaggatt ttccgccctt      840

gagccccttg tagatctccc catcggaatt aacataacca ggtttcaaac actgctggcg      900

ctccacagga gctatctgac cccgggcgac tcatccagtg ggtggaccgc cggagcagcc      960

gcatactacg tggggtatct ccagcccaga acgtttctcc tcaagtataa tgaaaacggg     1020

accatcaccg acgcggttga ttgtgcactc gatcccctca gcgagacaaa gtgcacactt     1080

aaatcattta ccgtcgagaa ggggatctac caaacatcca actttcgggt gcagcctacc     1140

gagtcaatag tacggtttcc taacatcacc aatttgtgcc cttttgggga agtatttaat     1200

gcaacccggt ttgcgagcgt atacgcttgg aaccgaaaac ggataagtaa ttgtgttgca     1260

gattattctg tgctctataa ctcagcttcc ttctccacct ttaagtgtta cggagtatct     1320

ccgacaaaat tgaatgatct ttgttttacg aatgtttacg ctgactcatt tgttatccga     1380

ggtgacgaag tgcgccagat agcccccggt caaacaggca acattgctga ttataactac     1440

aagttgcccg atgacttcac ggggtgtgtt attgcatgga attcaaataa tcttgatagt     1500

aaggtagggg gtaactataa ttacctttat cgcttgttcc gcaaatccaa tctgaaaccc     1560

ttcgaaaggg atatcagtac cgagatttat caagccggct ccacaccttg taacggagta     1620

aaaggtttta actgttattt cccactgcag agttacggct ttcaacccac atacggggtg     1680

ggatatcagc cctatcgcgt tgtggtcttg tcctttgaac ttctccacgc ccctgcaaca     1740

gtttgtggtc ctaaaaagag tacaaatctg gtaaaaaata agtgcgtcaa ctttaacttc     1800

aacggactga ctggtaccgg ggtcctcact gagagcaaca agaaattttt gcccttccag     1860

caattcggga gggatattgc cgatactacc gatgctgtac gggaccccca gacactcgaa     1920

atattggaca taaccccgtg ctcttttgga ggggtctctg tgattacccc gggtacgaac     1980

acgagtaatc aggtggcagt gctttatcag ggagtgaatt gcacagaagt accagtcgcg     2040

atccatgccg accagctcac gccgacctgg agggtttata gtacgggtag taacgttttc     2100

caaacacggg ccggttgtct catcggggca gagtacgtta ataacagcta tgaatgtgat     2160

atacccatag gtgccgggat ttgtgcttct tatcaaaccc aaaccaatag cagaagcgtt     2220

gcgtcacagt ctataatcgc ctatacgatg agcctcggag cggaaaactc agttgcctac     2280

tccaacaata gcattgctat cccaacgaac ttcactatta gcgtaaccac ggagatcctt     2340

ccagttagca tgacaaaaac tagcgtcgat tgcactatgt atatttgcgg cgacagtaca     2400

gagtgtagta atttgctcct gcagtacggg tctttctgca cccaattgaa ccgagcactg     2460

actggcatcg ccgtggaaca agacaaaaac acgcaagaag tatttgcgca agtcaagcag     2520

atttacaaga ctcccccgat caaagacttt ggcggattta attttagcca gatactcccc     2580

gatccatcta aaccatcaaa acggtccttt atagaagatc tcttgttcaa taaagtgaca     2640

ctcgcggacg cgggctttat caaacagtat ggggactgcc ttggagatat agctgcgagg     2700

gacttgattt gcgcccagaa attcaacggg ctgacggttc tgccgccgct cttgacagac     2760

gaaatgattg cacagtatac gagtgccttg ctggcaggga ctatcacttc cggttggacc     2820

ttcggcgcag gagcagcgct ccagatccca ttcgctatgc aaatggctta ccgattcaac     2880

ggaattggcg tcacacagaa cgtgctttac gagaatcaaa agctgattgc caatcaattc     2940

aactcagcga ttggcaaaat acaagatagt ctctcttcaa ctgcatccgc gctcggtaag     3000

ttgcaggacg tagtcaatca gaacgcacag gccctgaaca cgcttgttaa acaactgtct     3060

tcaaacttcg gtgcaataag ttccgtactt aatgatatct tgtcaaggtt ggataaggtc     3120

gaagctgagg tacaaatcga ccgccttata acaggcagac tccaatccct gcagacatac     3180

gtgacccagc aactcattag ggcagccgag atcagagcaa gtgccaacct cgctgctatt     3240

aaaatgtctg aatgcgtttt ggggcaatct aagcgggttg atttctgcgg taagggatac     3300

cacttgatgt cctttcctca gtccgctcct catggggtag tatttcttca tgttacatat     3360

gtaccagcac aagagaaaaa ttttactact gccccggcca tatgccatga tggcaaagcg     3420

cacttccctc gggagggggt ttttgtgtct aatggaaccc actggttcgt gactcagcgg     3480

aatttctatg aaccccagat tataactact gacaacactt tcgtttctgg aaactgcgat     3540

gtagtaatag gcatagtaaa taatacagta tatgatccct tgcaaccaga attggactct     3600

tttaaagaag agctcgacaa atattttaaa aaccatacat ctccagacgt tgatcttgga     3660

gacatctctg ggataaacgc tagcttcgta aacatacaaa aagaaatcga taggcttaac     3720

gaggtcgcaa aaaatcttaa tgaaagtctt atcgatttgc aagagcttgg aaagtatgag     3780

cagtatatca aatggccttc acgactggag gaagaactgc gccgacgcct gactgaatga     3840


<210>  52
<211>  1277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brazil Spike S1+S2 ECD_CD74+HLA

<400>  52

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Phe Thr Asn Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Ser Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
        115                 120                 125             


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
    130                 135                 140                 


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
145                 150                 155                 160 


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
                165                 170                 175     


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
            180                 185                 190         


Tyr Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
        195                 200                 205             


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
    210                 215                 220                 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
225                 230                 235                 240 


Phe Lys Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
                245                 250                 255     


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
            260                 265                 270         


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
        275                 280                 285             


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
305                 310                 315                 320 


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
                325                 330                 335     


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
            340                 345                 350         


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
        355                 360                 365             


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
    370                 375                 380                 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
385                 390                 395                 400 


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
                405                 410                 415     


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
            420                 425                 430         


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
        435                 440                 445             


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
    450                 455                 460                 


Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu 
465                 470                 475                 480 


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
                485                 490                 495     


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
            500                 505                 510         


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
        515                 520                 525             


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr 
    530                 535                 540                 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr 
545                 550                 555                 560 


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
                565                 570                 575     


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
            580                 585                 590         


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
        595                 600                 605             


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
    610                 615                 620                 


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
625                 630                 635                 640 


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
                645                 650                 655     


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys 
            660                 665                 670         


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
        675                 680                 685             


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
    690                 695                 700                 


Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
705                 710                 715                 720 


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Arg 
                725                 730                 735     


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
            740                 745                 750         


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
        755                 760                 765             


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
    770                 775                 780                 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
785                 790                 795                 800 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
                805                 810                 815     


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
            820                 825                 830         


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
        835                 840                 845             


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
    850                 855                 860                 


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
865                 870                 875                 880 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
                885                 890                 895     


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
            900                 905                 910         


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
        915                 920                 925             


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
    930                 935                 940                 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
945                 950                 955                 960 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
                965                 970                 975     


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
            980                 985                 990         


Ala Ser Ala Leu Gly Lys Leu Gln  Asp Val Val Asn Gln  Asn Ala Gln 
        995                 1000                 1005             


Ala Leu  Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
    1010                 1015                 1020             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1025                 1030                 1035             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1040                 1045                 1050             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1055                 1060                 1065             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Ile Lys Met  Ser Glu Cys 
    1070                 1075                 1080             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1085                 1090                 1095             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1100                 1105                 1110             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1115                 1120                 1125             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1130                 1135                 1140             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1145                 1150                 1155             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1160                 1165                 1170             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1175                 1180                 1185             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1190                 1195                 1200             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1205                 1210                 1215             


Asp Ile  Ser Gly Ile Asn Ala  Ser Phe Val Asn Ile  Gln Lys Glu 
    1220                 1225                 1230             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1235                 1240                 1245             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1250                 1255                 1260             


Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1265                 1270                 1275         


<210>  53
<211>  3837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Delta Spike S1+S2 ECD_CD74+HLA

<400>  53
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtta atcttacaac cagaactcaa      240

ttaccccctg catacactaa ttctttcaca cgtggtgttt attaccctga caaagttttc      300

agatcctcag ttttacattc aactcaggac ttgttcttac ctttcttttc caatgttact      360

tggttccatg ctatacatgt ctctgggacc aatggtacta agaggtttga taaccctgtc      420

ctaccattta atgatggtgt ttattttgct tccattgaga agtctaacat aataagaggc      480

tggatttttg gtactacttt agattcgaag acccagtccc tacttattgt taataacgct      540

actaatgttg ttattaaagt ctgtgaattt caattttgta atgatccatt tttgggtgtt      600

tattaccaca aaaacaacaa aagttggatg aaaagtgagt tcagagttta ttctagtgcg      660

aataattgca cttttgaata tgtctctcag ccttttctta tggaccttga aggaaaacag      720

ggtaatttca aaaatcttag ggaatttgtg tttaagaata ttgatggtta ttttaaaata      780

tattctaagc acacgcctat taatttagtg cgtgatctcc ctcagggttt ttcggcttta      840

gaaccattgg tagatttgcc aataggtatt aacatcacta ggtttcaaac tttacttgct      900

ttacatagaa gttatttgac tcctggtgat tcttcttcag gttggacagc tggtgctgca      960

gcttattatg tgggttatct tcaacctagg acttttctat taaaatataa tgaaaatgga     1020

accattacag atgctgtaga ctgtgcactt gaccctctct cagaaacaaa gtgtacgttg     1080

aaatccttca ctgtagaaaa aggaatctat caaacttcta actttagagt ccaaccaaca     1140

gaatctattg ttagatttcc taatattaca aacttgtgcc cttttggtga agtttttaac     1200

gccaccagat ttgcatctgt ttatgcttgg aacaggaaga gaatcagcaa ctgtgttgct     1260

gattattctg tcctatataa ttccgcatca ttttccactt ttaagtgtta tggagtgtct     1320

cctactaaat taaatgatct ctgctttact aatgtctatg cagattcatt tgtaattaga     1380

ggtgatgaag tcagacaaat cgctccaggg caaactggaa agattgctga ttataattat     1440

aaattaccag atgattttac aggctgcgtt atagcttgga attctaacaa acttgattct     1500

aaggttggtg gtaattataa ttaccgctat agattgttta ggaagtctaa tctcaaacct     1560

tttgagagag atatttcaac tgaaatctat caggccggta gcacaccttg taatggtgtt     1620

cagggtttta attgttactt tcctttacaa tcatatggtt tccaacccac ttatggtgtt     1680

ggttaccaac catacagagt agtagtactt tcttttgaac ttctacatgc accagcaact     1740

gtttgtggac ctaaaaagtc tactaatttg gttaaaaaca aatgtgtcaa tttcaacttc     1800

aatggtttaa caggcacagg tgttcttact gagtctaaca aaaagtttct gcctttccaa     1860

caatttggca gagacattga tgacactact gatgctgtcc gtgatccaca gacacttgag     1920

attcttgaca ttacaccatg ttcttttggt ggtgtcagtg ttataacacc aggaacaaat     1980

acttctaacc aggttgctgt tctttatcag ggtgttaact gcacagaagt ccctgttgct     2040

attcatgcag atcaacttac tcctacttgg cgtgtttatt ctacaggttc taatgttttt     2100

caaacacgtg caggctgttt aataggggct gaacatgtca acaactcata tgagtgtgac     2160

atacccattg gtgcaggtat atgcgctagt tatcagactc agactaattc tagtgtagct     2220

agtcaatcca tcattgccta cactatgtca cttggtgcag aaaattcagt tgcttactct     2280

aataactcta ttgccatacc cattaatttt actattagtg ttaccacaga aattctacca     2340

gtgtctatga ccaagacatc agtagattgt acaatgtaca tttgtggtga ttcaactgaa     2400

tgcagcaatc ttttgttgca atatggcagt ttttgtacac aattaaaccg tgctttaact     2460

ggaatagctg ttgaacaaga caaaaacacc caagaagttt ttgcacaagt caaacaaatt     2520

tacaaaacac caccaattaa agattttggt ggttttaatt tttcacaaat attaccagat     2580

ccatcaaaac caagcaagag gtcatttatt gaagatctac ttttcaacaa agtgacactt     2640

gcagatgctg gcttcatcaa acaatatggt gattgccttg gtgatattgc tgctagagac     2700

ctcatttgtg cacaaaagtt taacggcctt actgttttgc cacctttgct cacagatgaa     2760

atgattgctc aatacacttc tgcactgtta gcgggtacaa tcacttctgg ttggaccttt     2820

ggtgcaggtg ctgcattaca aataccattt gctatgcaaa tggcttatag gtttaatggt     2880

attggagtta cacagaatgt tctctatgag aaccaaaaat tgattgccaa ccaatttaat     2940

agtgctattg gcaaaattca agactcactt tcttccacag caagtgcact tggaaaactt     3000

caagatgtgg tcaaccaaaa tgcacaagct ttaaacacgc ttgttaaaca acttagctcc     3060

aattttggtg caatttcaag tgttttaaat gatatccttg cacgtcttga caaagttgag     3120

gctgaagtgc aaattgatag gttgatcaca ggcagacttc aaagtttgca gacatatgtg     3180

actcaacaat taattagagc tgcagaaatc agagcttctg ctaatcttgc tgctactaaa     3240

atgtcagagt gtgtacttgg acaatcaaaa agagttgatt tttgtggaaa gggctatcat     3300

cttatgtcct tccctcagtc agcacctcat ggtgtagtct tcttgcatgt gacttatgtc     3360

cctgcacacg aaaagaactt cacaactgct cctgccattt gtcatgatgg aaaagcacac     3420

tttcctcgtg aaggtgtctt tgtttcaaat ggcacacact ggtttgtaac acaaaggaat     3480

ttttatgaac cacaaatcat tactacacac aacacatttg tgtctggtaa ctgtgatgtt     3540

gtaataggaa ttgtcaacaa cacagtttat gatcctttgc aacctgaatt agactcattc     3600

aaggaggagt tagataaata ttttaagaat catacatcac cagatgttga tttaggtgac     3660

atctctggca ttaatgcttc agttgtaaac attcaaaaag aaattgaccg cctcaatgag     3720

gttgccaaga atttaaatga atctctcatc gatctccaag aacttggaaa gtatgagcag     3780

tatataaaat ggccatcacg actggaggaa gaactgcgcc gacgcctgac tgaataa        3837


<210>  54
<211>  1276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta Spike S1+S2 ECD_CD74+HLA

<400>  54

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
        115                 120                 125             


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
    130                 135                 140                 


Val Tyr Phe Ala Ser Ile Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
145                 150                 155                 160 


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
                165                 170                 175     


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
            180                 185                 190         


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
        195                 200                 205             


Lys Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
    210                 215                 220                 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
225                 230                 235                 240 


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
                245                 250                 255     


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
            260                 265                 270         


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
        275                 280                 285             


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
    290                 295                 300                 


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
305                 310                 315                 320 


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
                325                 330                 335     


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
            340                 345                 350         


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
        355                 360                 365             


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
    370                 375                 380                 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
385                 390                 395                 400 


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
                405                 410                 415     


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
            420                 425                 430         


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
        435                 440                 445             


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
    450                 455                 460                 


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
465                 470                 475                 480 


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu 
                485                 490                 495     


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg 
            500                 505                 510         


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
        515                 520                 525             


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Gln Gly Phe Asn Cys Tyr 
    530                 535                 540                 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr 
545                 550                 555                 560 


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
                565                 570                 575     


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
            580                 585                 590         


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
        595                 600                 605             


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
    610                 615                 620                 


Asp Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
625                 630                 635                 640 


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
                645                 650                 655     


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys 
            660                 665                 670         


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
        675                 680                 685             


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
    690                 695                 700                 


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
705                 710                 715                 720 


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Ser 
                725                 730                 735     


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
            740                 745                 750         


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe 
        755                 760                 765             


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
    770                 775                 780                 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
785                 790                 795                 800 


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
                805                 810                 815     


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
            820                 825                 830         


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
        835                 840                 845             


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
    850                 855                 860                 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
865                 870                 875                 880 


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
                885                 890                 895     


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
            900                 905                 910         


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
        915                 920                 925             


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
    930                 935                 940                 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
945                 950                 955                 960 


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
                965                 970                 975     


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
            980                 985                 990         


Ser Ala Leu Gly Lys Leu Gln Asp  Val Val Asn Gln Asn  Ala Gln Ala 
        995                 1000                 1005             


Leu Asn  Thr Leu Val Lys Gln  Leu Ser Ser Asn Phe  Gly Ala Ile 
    1010                 1015                 1020             


Ser Ser  Val Leu Asn Asp Ile  Leu Ala Arg Leu Asp  Lys Val Glu 
    1025                 1030                 1035             


Ala Glu  Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
    1040                 1045                 1050             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1055                 1060                 1065             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1070                 1075                 1080             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1085                 1090                 1095             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1100                 1105                 1110             


His Val  Thr Tyr Val Pro Ala  His Glu Lys Asn Phe  Thr Thr Ala 
    1115                 1120                 1125             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1130                 1135                 1140             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1145                 1150                 1155             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr His Asn Thr  Phe Val Ser 
    1160                 1165                 1170             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1175                 1180                 1185             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1190                 1195                 1200             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1205                 1210                 1215             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1220                 1225                 1230             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1235                 1240                 1245             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro 
    1250                 1255                 1260             


Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg Leu Thr  Glu 
    1265                 1270                 1275     


<210>  55
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Wuhan Spike S1+S2 ECD_HLA 

<400>  55
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt gaacctcact acgcgaactc aactgccgcc tgcttacact      120

aatagtttta cacgaggagt ctactacccg gacaaggtgt tccgctcaag tgtcttgcac      180

agcacgcaag acctgttctt gccatttttc agcaatgtaa cgtggtttca tgccatccac      240

gtgtcaggta ctaacggaac gaagagattt gataacccgg tcctcccgtt caacgacggg      300

gtttattttg ccagtacaga aaagtccaat attataaggg gatggatttt cggcacgact      360

ctcgactcta agacacaaag cttgctcatc gttaataatg ctacaaacgt ggttataaaa      420

gtatgcgagt tccaattctg taacgacccc tttctggggg tttactacca caaaaataat      480

aagagttgga tggagagcga attcagagtt tactcttccg cgaataattg caccttcgag      540

tacgtatccc agccttttct tatggatctt gaggggaaac aaggtaattt caaaaacctt      600

agagaattcg tttttaagaa tatagatgga tacttcaaga tttattctaa acatacccca      660

atcaatctgg tgcgcgatct tcctcagggt ttctctgcgc tggagcctct cgttgatctg      720

ccgatcggaa ttaatataac cagattccag acccttttgg cattgcaccg ctcctatctg      780

acacctgggg atagtagttc cggctggaca gcgggcgccg cggcatacta cgttggatat      840

ctccaacccc gcacttttct tctgaaatat aatgagaatg gaacgattac agacgcagta      900

gattgcgcgc ttgaccccct ttcagaaaca aagtgcacgc tgaaatcttt cacggtcgag      960

aagggcattt accaaacgtc caatttcaga gttcaaccca ctgagtctat agtcaggttt     1020

ccgaacatca ccaatctctg cccatttgga gaggttttca acgcaacacg gttcgcctct     1080

gtatacgcat ggaatagaaa gagaatatcc aattgtgtcg cagactatag tgtcttgtac     1140

aactctgcgt catttagcac ttttaaatgt tatggggtga gtccaactaa attgaacgat     1200

ctctgcttta caaatgttta cgcagatagt tttgtgatac gaggcgacga ggtacgacaa     1260

attgctcctg gccagaccgg gaaaatagcg gactacaatt ataaactgcc agacgatttc     1320

accggctgtg tgatcgcgtg gaactcaaac aacttggata gtaaggtagg tggtaactat     1380

aactacttgt accggctctt ccgcaaaagt aatcttaaac cgttcgagcg ggacatctct     1440

accgagatct atcaagcagg tagcactccc tgcaatggag tcgagggttt taattgctat     1500

tttcccctcc aatcatacgg gtttcagccc acaaatggtg ttgggtatca gccctatcga     1560

gttgtggtgc tttcatttga attgcttcat gcaccggcga cagtttgtgg tcctaaaaag     1620

agtaccaatt tggttaaaaa caaatgtgtc aactttaact ttaacggtct gactggtacg     1680

ggggtgctta cggaatctaa taaaaagttt cttccgttcc agcaattcgg acgggacata     1740

gcggacacga ctgacgcggt tagagaccca caaacactcg agattcttga cataaccccc     1800

tgttctttcg gcggagtttc tgtaataacg cctgggacaa atacgtcaaa ccaggttgca     1860

gtattgtacc aggatgtcaa ctgcactgaa gtgccagtcg cgatccacgc agatcagttg     1920

actccaacat ggagggtcta ctctaccggt tctaacgtgt ttcagaccag agccgggtgc     1980

ctcattggcg cggaacatgt gaacaattct tacgaatgcg acatacccat cggcgccggc     2040

atttgtgcgt cataccaaac tcaaactaat tcccggagtg tggcctccca atctattatt     2100

gcttatacta tgagtcttgg cgcggaaaac agtgtagcgt actcaaataa ctctattgcg     2160

atccccacga atttcactat aagcgtaact actgaaattt tgccggtaag catgacgaaa     2220

acttcagtgg actgcacaat gtacatttgt ggtgacagca ctgagtgctc aaatctcctc     2280

cttcagtatg gttctttctg cacacaactt aacagggcac ttaccggaat cgcagtagaa     2340

caagacaaaa acacgcaaga agtattcgca caggtcaaac aaatttataa aaccccgccg     2400

atcaaggatt ttggagggtt taacttcagt cagatccttc cagacccatc caaacccagc     2460

aaacggagct ttattgaaga cctgctgttt aataaagtta cccttgcaga tgccggtttc     2520

atcaagcaat acggggattg tctgggcgac attgccgccc gcgacttgat ctgtgcccag     2580

aagttcaacg gtctcacagt cttgccgcca cttctcactg atgaaatgat agcgcagtat     2640

acatccgcgc tgctggctgg gacgataaca tctggttgga ctttcggggc cggggcggct     2700

ttgcaaattc ctttcgccat gcagatggcc tataggttta acggcatagg agtgactcaa     2760

aatgttcttt atgagaatca gaagcttatc gccaaccaat ttaactccgc gattgggaag     2820

atacaggact cattgagctc tactgctagc gcccttggca agcttcaaga cgtagtcaac     2880

caaaatgctc aagcgctcaa tactctcgta aagcagctct caagcaactt tggcgcgata     2940

tcttcagttt tgaacgacat cttgagcaga ctcgacaagg tggaggctga agttcaaatt     3000

gatcgactga ttacgggccg gctccagtca ctccaaacgt acgtgaccca acaactcatt     3060

agagcggcag agattagagc gagcgctaat ctggcggcca caaagatgtc agaatgtgtg     3120

cttggtcaat ccaaaagggt ggatttctgc ggaaagggct atcacttgat gagtttcccg     3180

cagtccgcgc ctcatggagt tgttttcctc cacgtaacct acgttcccgc tcaggaaaag     3240

aatttcacga cagctccggc aatatgtcat gacggtaaag cacatttccc cagggaaggc     3300

gtttttgtca gtaatggaac ccactggttc gtcacccagc gaaactttta cgagccccaa     3360

ataataacta ctgacaatac cttcgtcagc ggcaattgcg acgtcgtcat aggcatagta     3420

aataatacgg tttacgaccc tcttcaaccc gagttggaca gcttcaaaga agaacttgat     3480

aagtatttta aaaaccacac tagcccagat gtagaccttg gcgacatcag cggtatcaat     3540

gcttccgttg tgaacattca aaaggaaatt gaccgactca atgaagtagc gaagaacttg     3600

aatgagtctc tgatcgatct tcaggagctc gggaaatatg agcaatacat caaatggccg     3660

gtaggtatta tagccgggct cgtgttgttg ggtgcagtaa tcacaggagc cgtcgtggca     3720

gcggttatgt ggagacggaa atcttcagac cgcaaaggtg gtagttacac tcaagcggct     3780

tccagtgatt ctgcccaggg ctccgacgta tccctcactg cgtgtaaggt ttcacgactg     3840

gaggaagaac tgcgccgacg cctgactgaa tga                                  3873


<210>  56
<211>  1288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wuhan Spike S1+S2 ECD_HLA

<400>  56

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro 
    1205                 1210                 1215             


Val Gly  Ile Ile Ala Gly Leu  Val Leu Leu Gly Ala  Val Ile Thr 
    1220                 1225                 1230             


Gly Ala  Val Val Ala Ala Val  Met Trp Arg Arg Lys  Ser Ser Asp 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ser Tyr Thr  Gln Ala Ala Ser Ser  Asp Ser Ala 
    1250                 1255                 1260             


Gln Gly  Ser Asp Val Ser Leu  Thr Ala Cys Lys Val  Ser Arg Leu 
    1265                 1270                 1275             


Glu Glu  Glu Leu Arg Arg Arg  Leu Thr Glu 
    1280                 1285             


<210>  57
<211>  3867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Kent Spike S1+S2 ECD_HLA 

<400>  57
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt taacctgaca acacgcaccc agttgccacc ggcctatacg      120

aactctttca cgcgcggagt gtattatccc gataaagtct ttcggagttc tgtgctgcac      180

tctacacaag atctttttct gccctttttc tccaacgtta cgtggttcca tgcaataagt      240

ggtacgaatg gtactaaaag gttcgataat cccgtacttc ccttcaatga cggcgtgtat      300

ttcgcgagca cagaaaagag caacataata agaggttgga tttttgggac taccctggac      360

tctaaaacac aaagcctcct cattgttaat aacgcaacta atgtcgtaat aaaggtatgc      420

gaatttcagt tttgtaacga cccttttttg ggagtctatc ataagaacaa taagtcctgg      480

atggaaagtg aatttagggt gtatagttca gcgaacaact gtacatttga gtatgtgtca      540

cagccgttcc ttatggatct tgaagggaaa caggggaact tcaagaacct gcgggaattc      600

gtgtttaaaa atatagacgg ttattttaaa atctatagca aacacacccc aataaacctg      660

gttcgggatc ttcctcaggg attttcagct ttggaaccgt tggttgacct ccccatcggg      720

ataaatatca cgcgatttca aacactgctg gcactgcacc ggagttatct gactcctgga      780

gatagcagct ccggctggac ggctggcgcc gcggcttatt atgtcgggta ccttcaaccg      840

cgaacgtttc ttttgaagta taacgaaaat ggcactataa ccgatgcagt agattgtgcg      900

ttggaccctc tttccgagac taagtgcacc ctgaagtcat ttacagtaga gaaggggata      960

taccagacaa gcaacttccg cgtccaacca acggaaagca tcgtgcgctt tcccaatatt     1020

actaacctct gtccgttcgg cgaggttttt aatgctacca gatttgcctc agtgtatgcc     1080

tggaaccgca agaggattag caactgcgtt gctgactata gcgtgcttta caattccgcc     1140

agttttagta cgttcaagtg ttatggggta agccctacca agcttaacga tctttgcttc     1200

acgaatgttt acgcagactc attcgtaata cgaggtgatg aagtgcgaca gatagccccg     1260

ggtcagacgg ggaaaatagc cgactacaat tacaagctcc cggacgactt cacgggctgt     1320

gttattgcgt ggaacagcaa taacctggac agtaaagttg gagggaatta taactacttg     1380

tacaggctgt tccgcaaatc taatttgaaa ccgtttgaaa gggacatttc caccgagatt     1440

taccaagccg gcagtacccc atgtaacgga gttgagggat ttaattgcta ctttccgctc     1500

caatcatatg gattccagcc tacatacggc gtcggatatc aaccttatag ggtggtcgtt     1560

ctttcttttg agctgcttca cgccccagca accgtttgcg gcccgaaaaa atcaacgaac     1620

ttggtcaaaa acaagtgcgt caacttcaat ttcaacggac tgacaggcac cggagtgctc     1680

accgagtcaa ataaaaaatt cctcccgttt caacaattcg gtagagatat agacgacacc     1740

acagatgcgg tacgcgaccc tcagactctt gaaattttgg acattacacc atgttccttc     1800

ggtggcgtct cagtgattac gcctggcact aacactagca accaagtcgc agtactttat     1860

cagggcgtta actgtacaga agtaccagtt gcgatacacg cggaccagct caccccaacc     1920

tggcgcgtat attctaccgg atctaatgtg tttcaaacgc gggcggggtg cctcataggt     1980

gcagagcatg tcaataactc ctacgaatgt gacattccta taggagcagg aatatgtgcg     2040

agctaccaga ctcaaaccaa ttcacacagg agcgtagcta gtcagtccat aattgcctac     2100

actatgtcac ttggtgctga aaacagtgtg gcttattcaa ataattccat agctattcca     2160

atcaatttca ctattagcgt aacaactgag atacttccag tcagcatgac taagacttca     2220

gttgattgta cgatgtatat ttgtggcgat tctacagaat gtagtaacct tctgttgcaa     2280

tacggctcct tttgcacaca gctcaatcgc gcattgacgg gtatagctgt agagcaagat     2340

aaaaacaccc aagaagtctt cgcgcaggtg aagcaaatat ataagacacc accgattaaa     2400

gatttcggtg gattcaattt tagccaaatt ctgcctgatc caagcaaacc gtcaaaaaga     2460

tccttcatag aggacctgct tttcaataag gtaacgctgg cggacgcagg gtttattaaa     2520

caatacggcg attgccttgg tgacattgct gcacgagacc tcatttgcgc ccagaagttc     2580

aacggactca cagtactgcc tccactgctc acagacgaga tgatcgccca gtacacatct     2640

gccttgttgg ctggtacgat aacttctggt tggacctttg gagcgggagc agcacttcag     2700

attccctttg ccatgcagat ggcgtacaga ttcaacggca ttggtgtcac gcagaacgta     2760

ctgtatgaga accagaagtt gatagctaat caattcaact ccgcgatagg taagatccaa     2820

gacagtctct cctcaacagc ctccgcactc gggaaactcc aggatgtggt aaatcagaat     2880

gcacaggcat tgaatacgct tgttaaacaa ttgtcctcaa attttggcgc catatcatca     2940

gtgctcaacg acatccttgc cagactcgat aaagtggagg cagaagtgca gatagatcgc     3000

ttgattactg ggcgcctcca atctctccaa acgtacgtga cacaacagct tattcgggca     3060

gcggaaatcc gcgcctctgc gaaccttgca gcgaccaaga tgagcgaatg tgttctcggg     3120

cagtcaaaac gagtagattt ctgcggtaaa ggatatcatc ttatgtcatt cccccaaagc     3180

gctccacatg gtgttgtatt tctgcacgtg acttacgtgc cggcacagga gaagaatttc     3240

acaacggctc ccgccatctg tcacgacgga aaggcacact tccctaggga gggggtgttt     3300

gtaagcaatg gtacccactg gtttgtcaca caacgaaact tctatgaacc tcagataatt     3360

acaacgcata atacttttgt aagtgggaac tgcgacgtcg ttatcggaat agttaacaat     3420

actgtatatg atccgttgca gccggagttg gactcattta aagaagagct ggacaagtac     3480

ttcaaaaacc atacaagccc agatgtagat cttggggaca taagtgggat aaacgccagc     3540

gttgtgaaca tacagaagga aatagacagg ctgaatgagg tagcaaagaa tcttaacgaa     3600

agccttatag atcttcagga acttgggaag tacgaacagt acataaagtg gcctgtaggt     3660

attatagccg ggctcgtgtt gttgggtgca gtaatcacag gagccgtcgt ggcagcggtt     3720

atgtggagac ggaaatcttc agaccgcaaa ggtggtagtt acactcaagc ggcttccagt     3780

gattctgccc agggctccga cgtatccctc actgcgtgta aggtttcacg actggaggaa     3840

gaactgcgcc gacgcctgac tgaatga                                         3867


<210>  58
<211>  1286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kent Spike S1+S2 ECD_HLA

<400>  58

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr 
65                  70                  75                  80  


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
                85                  90                  95      


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
            100                 105                 110         


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
        115                 120                 125             


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
    130                 135                 140                 


Asp Pro Phe Leu Gly Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser His Arg 
        675                 680                 685             


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
    690                 695                 700                 


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn 
705                 710                 715                 720 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
                725                 730                 735     


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
            740                 745                 750         


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
        755                 760                 765             


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
    770                 775                 780                 


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
785                 790                 795                 800 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
                805                 810                 815     


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
            820                 825                 830         


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
        835                 840                 845             


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
    850                 855                 860                 


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
865                 870                 875                 880 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
                885                 890                 895     


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
            900                 905                 910         


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
        915                 920                 925             


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
    930                 935                 940                 


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
945                 950                 955                 960 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
                965                 970                 975     


Ser Ser Val Leu Asn Asp Ile Leu Ala Arg Leu Asp Lys Val Glu Ala 
            980                 985                 990         


Glu Val Gln Ile Asp Arg Leu Ile  Thr Gly Arg Leu Gln  Ser Leu Gln 
        995                 1000                 1005             


Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
    1010                 1015                 1020             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1025                 1030                 1035             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1040                 1045                 1050             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1055                 1060                 1065             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1070                 1075                 1080             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1085                 1090                 1095             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1100                 1105                 1110             


Glu Pro  Gln Ile Ile Thr Thr  His Asn Thr Phe Val  Ser Gly Asn 
    1115                 1120                 1125             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1130                 1135                 1140             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1145                 1150                 1155             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1160                 1165                 1170             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1175                 1180                 1185             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1190                 1195                 1200             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Val Gly 
    1205                 1210                 1215             


Ile Ile  Ala Gly Leu Val Leu  Leu Gly Ala Val Ile  Thr Gly Ala 
    1220                 1225                 1230             


Val Val  Ala Ala Val Met Trp  Arg Arg Lys Ser Ser  Asp Arg Lys 
    1235                 1240                 1245             


Gly Gly  Ser Tyr Thr Gln Ala  Ala Ser Ser Asp Ser  Ala Gln Gly 
    1250                 1255                 1260             


Ser Asp  Val Ser Leu Thr Ala  Cys Lys Val Ser Arg  Leu Glu Glu 
    1265                 1270                 1275             


Glu Leu  Arg Arg Arg Leu Thr  Glu 
    1280                 1285     


<210>  59
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding South Africa Spike S1+S2 ECD_HLA

<400>  59
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt caatttcact acacgcacac agctgccccc ggcgtacact      120

aacagtttta cgaggggagt ctactacccg gacaaagtgt tcaggtcttc cgtactccat      180

agcacacaag acctcttctt gccttttttc agcaatgtta cgtggttcca tgcaatccat      240

gtgagcggta caaacgggac taaacgcttt gcaaatccag tgttgccctt caacgacggt      300

gtatacttcg cgagtacaga gaagagcaac ataatacgcg ggtggatatt tggaacgacg      360

cttgattcta agacacagag cttgctcatc gtaaacaacg caacgaatgt tgtaatcaag      420

gtctgcgaat tccaattctg caatgaccca tttcttggag tttattacca taagaacaat      480

aagtcttgga tggaatccga gttccgcgta tactctagcg cgaacaactg caccttcgag      540

tatgtgtccc aaccgtttct gatggatctt gagggaaagc agggtaattt taaaaatctc      600

cgggagttcg ttttcaaaaa tattgacgga tatttcaaaa tctacagcaa gcatacccca      660

atcaatttgg tgcggggtct gccacaagga ttttccgctc ttgaacctct tgttgacctt      720

cccataggaa tcaatataac tcggttccaa actcttcttg cgctccatat atcctacttg      780

acgcccggag attcatcaag tggctggacg gctggggctg ccgcatacta cgtcggctat      840

ctgcaaccaa ggacgtttct cctcaaatac aatgaaaatg gtacgatcac cgacgctgtg      900

gactgcgctc tcgacccgtt gtcagagacg aagtgcacct tgaagtcctt caccgtggaa      960

aagggaattt accagactag taacttccgg gtgcagccca cggaatcaat tgtgcgattt     1020

cctaatatca ctaatctctg tcccttcggg gaagtgttca atgcgactcg attcgcttca     1080

gtatacgctt ggaatagaaa gagaatctca aattgcgtgg ctgactattc cgtactgtat     1140

aatagtgcgt cttttagcac gtttaagtgt tatggcgtat ccccgacaaa gctcaacgat     1200

ctctgcttca cgaatgtcta tgccgactcc ttcgtgatac gcggtgacga ggtacgacaa     1260

attgcacccg gccaaactgg aaatattgcc gactacaatt ataagttgcc ggacgatttt     1320

accggttgcg taatagcgtg gaactctaat aacctcgact ctaaggtagg aggcaactac     1380

aattacttgt accgactgtt caggaaatcc aacctgaagc ccttcgaaag agacatcagt     1440

acagagattt atcaagccgg gtccacccct tgcaatggtg tcaaaggctt caactgctat     1500

tttccgttgc agtcttacgg tttccagccg acgtacggtg tgggttatca accctaccgc     1560

gttgtggtgc tgagctttga gcttctccac gctccagcca ctgtctgcgg gcctaagaaa     1620

tccacaaacc tcgttaagaa taaatgcgta aatttcaact tcaacgggct tactggcacg     1680

ggcgtgctta cggagtccaa taagaaattc ctgcctttcc agcagttcgg ccgcgacatc     1740

gcggacacaa cagatgctgt gcgagaccca caaaccctgg agattctgga catcacgcct     1800

tgctcttttg gcggtgtcag cgtaataacg ccaggcacca acaccagtaa tcaggtcgcc     1860

gtgctttatc agggtgtgaa ctgtacggag gtaccggttg ccatacacgc agaccaactc     1920

acacctacgt ggagagttta cagcaccggg tcaaacgtat ttcagacccg cgcaggctgt     1980

ctgatcggcg cagagcatgt caataactca tacgagtgtg atataccaat cggagccggc     2040

atctgtgcga gctatcaaac ccaaactaat tcacgaagcg tggccagcca gtccatcatt     2100

gcctacacga tgtctttggg agtagagaat agcgtggcat actctaacaa cagtatcgct     2160

attcctacca acttcacaat atcagttact acagaaatcc tcccggtgag catgactaag     2220

acatccgtag actgtacaat gtacatttgt ggggacagca cggagtgttc aaacctgctg     2280

ttgcaatacg gaagcttctg cacccagctc aaccgagccc tgaccggcat tgccgtagaa     2340

caagataaga atacgcagga agtgttcgcc caggttaagc agatttacaa gactccgcct     2400

atcaaggact tcgggggttt caactttagt cagattttgc ctgacccgtc aaagcctagc     2460

aaacgaagtt ttatcgaaga tttgttgttt aacaaggtga ctttggctga tgcgggattc     2520

ataaaacaat acggcgattg ccttggcgat attgcggccc gagatctcat ttgcgcgcaa     2580

aagttcaacg gtcttaccgt ccttccgccc ctgcttacgg acgagatgat cgcacaatac     2640

acttcagcac tgctggctgg tacaataacc agtgggtgga cattcggggc tggtgcagcg     2700

ctccagatcc cctttgcgat gcagatggcg tatagattca atggcatcgg ggtcactcag     2760

aacgtgcttt atgagaacca aaagcttatt gcaaatcaat ttaactctgc gattggaaag     2820

attcaagaca gcctctcatc cacagctagt gcgcttggca agcttcagga cgtcgtaaac     2880

caaaacgccc aagctctcaa cacactcgtt aaacagcttt cctcaaactt tggggctatt     2940

agctctgtgc tgaatgatat tcttagcaga ctcgacaaag tcgaggctga agtacaaata     3000

gatagactga taacaggtag acttcagtct ctccaaacct acgtgacaca gcagcttata     3060

agagctgctg agatcagagc ttctgcgaac cttgcggcga ctaaaatgtc cgagtgtgta     3120

ctcgggcagt ctaaacgcgt cgacttctgt ggcaagggtt accatctcat gagttttccc     3180

caatcagcgc cccatggggt agtttttctg cacgtaacat acgtcccagc ccaagaaaag     3240

aattttacca ccgcccctgc gatttgtcac gacggaaaag cacactttcc aagagaaggc     3300

gtatttgtta gcaatggcac ccattggttc gtcacccaga gaaactttta cgaaccgcag     3360

attatcacga cagataatac atttgtatct ggtaattgtg acgtcgtgat cggcatcgta     3420

aacaacactg tttacgaccc cctccagcca gagcttgact catttaaaga ggagctcgac     3480

aaatatttta agaaccacac aagtccagac gtcgacttgg gtgacatttc cggcatcaat     3540

gcaagtgtgg tcaacatcca aaaggaaatt gacagattga acgaggttgc taagaacctt     3600

aatgagtcac tcattgacct ccaggaactg ggaaaatacg aacagtatat taagtggccc     3660

gtaggtatta tagccgggct cgtgttgttg ggtgcagtaa tcacaggagc cgtcgtggca     3720

gcggttatgt ggagacggaa atcttcagac cgcaaaggtg gtagttacac tcaagcggct     3780

tccagtgatt ctgcccaggg ctccgacgta tccctcactg cgtgtaaggt ttcacgactg     3840

gaggaagaac tgcgccgacg cctgactgaa tga                                  3873


<210>  60
<211>  1288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  South Africa Spike S1+S2 ECD_HLA

<400>  60

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Phe Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Ile Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Val Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro 
    1205                 1210                 1215             


Val Gly  Ile Ile Ala Gly Leu  Val Leu Leu Gly Ala  Val Ile Thr 
    1220                 1225                 1230             


Gly Ala  Val Val Ala Ala Val  Met Trp Arg Arg Lys  Ser Ser Asp 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ser Tyr Thr  Gln Ala Ala Ser Ser  Asp Ser Ala 
    1250                 1255                 1260             


Gln Gly  Ser Asp Val Ser Leu  Thr Ala Cys Lys Val  Ser Arg Leu 
    1265                 1270                 1275             


Glu Glu  Glu Leu Arg Arg Arg  Leu Thr Glu 
    1280                 1285             


<210>  61
<211>  3870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding California Spike S1+S2 ECD_HLA

<400>  61
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt aaatttgaca acgcgcaccc aattgccccc agcatatacg      120

aactctttca cgaggggcgt atattatccg gataaggtat ttcggtcatc tgttctgcac      180

agcacccagg acctcttcct tccattcttt tcaaatgtaa cttggttcca tgcgatagta      240

tcaggaacga atgggacaaa aaggttcgat aatccggtct tgccgttcaa cgatggggtg      300

tacttcgcca gtaccgaaaa gtctaacatt atacgcggtt ggatttttgg cactacgctt      360

gactcaaaga cacagtcact cctcattgta aataatgcta ctaatgtcgt gatcaaagtt      420

tgtgagttcc aattctgcaa cgacccgttc ctgggagtgt attatcacaa aaataataag      480

tcctgcatgg agtcagagtt cagggtttac tcaagtgcga acaattgcac atttgagtac      540

gtttctcaac catttctcat ggatttggag gggaagcagg gaaactttaa aaacctgaga      600

gaatttgttt ttaagaacat tgatgggtat ttcaagattt atagtaaaca cacccctatc      660

aacttggtta gggatctccc tcaaggtttc tctgctctcg agccccttgt agatctgcca      720

ataggcatca atatcacacg ctttcagaca ctcctcgcac ttcataggag ctacctgacg      780

ccaggtgact cttcctcagg ttggacagcc ggcgcagccg catactacgt tggctacctc      840

caaccaagga catttctgtt gaaatacaac gaaaatggga ccatcaccga cgcagtcgat      900

tgtgctctcg accctctttc cgagactaaa tgtaccctca aaagctttac tgttgagaag      960

ggtatctatc agacatctaa ctttcgggtg caacccactg agtcaattgt gcgattccca     1020

aatattacga acctctgtcc ttttggcgag gtttttaacg ccactaggtt cgccagtgta     1080

tatgcttgga accgaaaacg gataagcaat tgtgttgctg actactccgt cctctacaat     1140

agcgctagtt tctcaacatt taagtgttac ggtgtgagcc ctacgaaact taacgatttg     1200

tgcttcacta acgtctatgc cgacagtttc gtaatccgag gcgatgaggt caggcaaatt     1260

gccccgggcc aaacggggaa aatcgctgat tacaattata agttgccaga tgattttacg     1320

ggatgtgtca ttgcatggaa cagtaataac ctcgattcaa aggttggcgg aaattataat     1380

tacagatatc ggctttttag aaaatctaac cttaaaccat ttgagcggga cataagcacg     1440

gagatttacc aggctggtag cactccgtgc aacggtgtag aaggattcaa ttgctatttt     1500

ccattgcagt cttatggatt ccaacccacc aatggggtag ggtaccaacc atacagggtg     1560

gtagtcctta gctttgaact tttgcatgcg ccagctaccg tctgcggtcc caaaaagagt     1620

acgaacttgg taaaaaataa atgcgtcaac tttaatttta acggtctgac gggaacgggg     1680

gttctcaccg agtctaacaa aaagtttttg ccatttcagc agttcggacg agatattgcc     1740

gacactaccg acgccgtgcg cgatccacaa accttggaga tactcgacat cacaccttgc     1800

agcttcggtg gtgttagcgt tattacgcca ggaacgaaca cttcaaatca ggtggccgtc     1860

ttgtatcaag atgttaactg tacagaggtg cccgtcgcaa tacacgcaga tcagctcacc     1920

cctacctgga gagtttactc tacaggctct aatgtgttcc aaactagggc aggctgcttg     1980

attggagctg aacacgtaaa caactcatac gagtgcgata tcccgattgg tgcgggtatt     2040

tgcgccagct atcagacgca gactaactca cgatcagtgg cgtcacagtc aataattgcg     2100

tatacaatga gtctcggtgc agagaattcc gtcgcatact caaacaacag catagcgatt     2160

ccaactaatt ttaccattag cgttacaacg gaaatcctcc ccgttagcat gaccaagacc     2220

tccgtggatt gcacaatgta catctgtgga gacagcaccg agtgctccaa tcttcttctt     2280

caatatggga gcttttgcac acagctgaac cgcgcgctca ctggcattgc ggtagaacaa     2340

gacaaaaaca cccaagaagt gtttgcgcag gtcaaacaga tttacaagac accaccaatc     2400

aaagacttcg gggggttcaa tttctcccaa attcttcctg atccaagcaa accatctaaa     2460

aggtccttca tagaagacct cctgttcaat aaggtgacac tcgcggacgc agggtttatt     2520

aagcaatatg gagattgtct cggggatatt gcagcgagag atcttatttg tgctcaaaag     2580

tttaatggct tgactgtcct cccgcccttg ctcacagacg agatgatagc acaatatacc     2640

agtgcgctgc ttgcgggcac gattacttcc ggatggactt tcggggcagg agcggcgctc     2700

cagattcctt tcgcgatgca aatggcctac cgatttaacg ggattggcgt cacacaaaac     2760

gttctttacg aaaaccagaa acttattgcc aaccaattca atagtgcaat tggtaaaatt     2820

caggattcac tctcctccac ggcgtcagct ctcggcaagc tccaagacgt ggttaaccaa     2880

aatgcgcagg cgcttaacac gcttgtaaaa caactctctt ctaattttgg cgcgattagt     2940

agcgttctca acgatatctt gtcacgcttg gacaaagtag aagcagaagt ccaaatagac     3000

cggctgatca ctggtcgatt gcaatctctg cagacatacg tgacgcagca gctcatccgg     3060

gcagccgaga tccgggcgtc cgctaatctg gccgcaacca aaatgagcga gtgtgtcctt     3120

gggcaaagca aacgcgtgga tttttgcgga aagggctacc acctcatgag tttcccccaa     3180

tctgccccgc acggtgtcgt ctttttgcat gtaacgtatg tcccggcgca ggagaaaaat     3240

ttcactacag ctcccgccat ctgtcacgac ggcaaggcac acttccctcg agaaggggtg     3300

tttgtaagca atggaacaca ctggttcgtc acccagcgga atttttatga acctcagata     3360

atcacaacag acaacacttt cgtttccgga aactgcgatg tcgtaattgg gatagtgaat     3420

aataccgtat atgacccatt gcagccggag ttggactcct ttaaagagga attggacaaa     3480

tactttaaaa atcacacttc acccgatgtg gacctgggag atatatccgg gattaacgca     3540

agtgtggtta acatacaaaa ggaaattgac cgccttaacg aggttgctaa gaacttgaat     3600

gagtctctca tagatctcca ggaactgggg aaatacgagc aatatatcaa atggccggta     3660

ggtattatag ccgggctcgt gttgttgggt gcagtaatca caggagccgt cgtggcagcg     3720

gttatgtgga gacggaaatc ttcagaccgc aaaggtggta gttacactca agcggcttcc     3780

agtgattctg cccagggctc cgacgtatcc ctcactgcgt gtaaggtttc acgactggag     3840

gaagaactgc gccgacgcct gactgaatga                                      3870


<210>  62
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  California Spike S1+S2 ECD_HLA

<400>  62

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile Val Ser Gly 
65                  70                  75                  80  


Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp 
                85                  90                  95      


Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val 
        115                 120                 125             


Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys 
    130                 135                 140                 


Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Cys 
145                 150                 155                 160 


Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe 
                165                 170                 175     


Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly 
            180                 185                 190         


Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr 
        195                 200                 205             


Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu 
    210                 215                 220                 


Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly 
225                 230                 235                 240 


Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr 
                245                 250                 255     


Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala 
            260                 265                 270         


Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn 
        275                 280                 285             


Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu 
    290                 295                 300                 


Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile 
305                 310                 315                 320 


Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
                325                 330                 335     


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            340                 345                 350         


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        355                 360                 365             


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    370                 375                 380                 


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
385                 390                 395                 400 


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                405                 410                 415     


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            420                 425                 430         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        435                 440                 445             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe 
    450                 455                 460                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
465                 470                 475                 480 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                485                 490                 495     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            500                 505                 510         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        515                 520                 525             


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn 
    530                 535                 540                 


Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu 
545                 550                 555                 560 


Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp 
                565                 570                 575     


Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile 
            580                 585                 590         


Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro 
        595                 600                 605             


Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn 
    610                 615                 620                 


Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr 
625                 630                 635                 640 


Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly 
                645                 650                 655     


Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile 
            660                 665                 670         


Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser 
        675                 680                 685             


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
    690                 695                 700                 


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
705                 710                 715                 720 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
                725                 730                 735     


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
            740                 745                 750         


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
        755                 760                 765             


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
    770                 775                 780                 


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
785                 790                 795                 800 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
                805                 810                 815     


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
            820                 825                 830         


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
        835                 840                 845             


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
    850                 855                 860                 


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
865                 870                 875                 880 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
                885                 890                 895     


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
            900                 905                 910         


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
        915                 920                 925             


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
    930                 935                 940                 


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
945                 950                 955                 960 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
                965                 970                 975     


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
            980                 985                 990         


Ala Glu Val Gln Ile Asp Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu 
        995                 1000                 1005             


Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
    1010                 1015                 1020             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1025                 1030                 1035             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1040                 1045                 1050             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1055                 1060                 1065             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1070                 1075                 1080             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1085                 1090                 1095             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1100                 1105                 1110             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1115                 1120                 1125             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1130                 1135                 1140             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1145                 1150                 1155             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1160                 1165                 1170             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1175                 1180                 1185             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1190                 1195                 1200             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Val 
    1205                 1210                 1215             


Gly Ile  Ile Ala Gly Leu Val  Leu Leu Gly Ala Val  Ile Thr Gly 
    1220                 1225                 1230             


Ala Val  Val Ala Ala Val Met  Trp Arg Arg Lys Ser  Ser Asp Arg 
    1235                 1240                 1245             


Lys Gly  Gly Ser Tyr Thr Gln  Ala Ala Ser Ser Asp  Ser Ala Gln 
    1250                 1255                 1260             


Gly Ser  Asp Val Ser Leu Thr  Ala Cys Lys Val Ser  Arg Leu Glu 
    1265                 1270                 1275             


Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1280                 1285         


<210>  63
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Brazil Spike S1+S2 ECD_HLA

<400>  63
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt taactttact aatcggaccc aactcccgag tgcgtacact      120

aactctttta cccggggcgt ctattatcct gacaaagtgt ttcgatcatc tgttttgcac      180

tccacccaag atctctttct tccatttttc agcaacgtta cgtggttcca cgcgatacat      240

gttagtggta ctaatggcac aaagagattt gacaaccctg tgctcccgtt taacgatggg      300

gtctatttcg cttccactga gaagtccaac attattcgcg gttggatctt cggcaccaca      360

ctcgattcaa aaacccaaag cttgctcata gttaacaacg ccacaaacgt agtcattaaa      420

gtgtgcgaat ttcagttttg taactatccc tttttgggcg tctactatca caagaacaac      480

aagtcctgga tggaatctga gtttcgggtc tacagttcag ccaacaactg tacgtttgag      540

tacgttagcc agccctttct gatggatctt gaagggaagc aaggaaattt caagaatctt      600

tccgagtttg tgtttaaaaa tatagacgga tatttcaaga tatacagtaa gcacacaccg      660

atcaatttgg tacgggattt gccgcaagga ttttccgccc ttgagcccct tgtagatctc      720

cccatcggaa ttaacataac caggtttcaa acactgctgg cgctccacag gagctatctg      780

accccgggcg actcatccag tgggtggacc gccggagcag ccgcatacta cgtggggtat      840

ctccagccca gaacgtttct cctcaagtat aatgaaaacg ggaccatcac cgacgcggtt      900

gattgtgcac tcgatcccct cagcgagaca aagtgcacac ttaaatcatt taccgtcgag      960

aaggggatct accaaacatc caactttcgg gtgcagccta ccgagtcaat agtacggttt     1020

cctaacatca ccaatttgtg cccttttggg gaagtattta atgcaacccg gtttgcgagc     1080

gtatacgctt ggaaccgaaa acggataagt aattgtgttg cagattattc tgtgctctat     1140

aactcagctt ccttctccac ctttaagtgt tacggagtat ctccgacaaa attgaatgat     1200

ctttgtttta cgaatgttta cgctgactca tttgttatcc gaggtgacga agtgcgccag     1260

atagcccccg gtcaaacagg caacattgct gattataact acaagttgcc cgatgacttc     1320

acggggtgtg ttattgcatg gaattcaaat aatcttgata gtaaggtagg gggtaactat     1380

aattaccttt atcgcttgtt ccgcaaatcc aatctgaaac ccttcgaaag ggatatcagt     1440

accgagattt atcaagccgg ctccacacct tgtaacggag taaaaggttt taactgttat     1500

ttcccactgc agagttacgg ctttcaaccc acatacgggg tgggatatca gccctatcgc     1560

gttgtggtct tgtcctttga acttctccac gcccctgcaa cagtttgtgg tcctaaaaag     1620

agtacaaatc tggtaaaaaa taagtgcgtc aactttaact tcaacggact gactggtacc     1680

ggggtcctca ctgagagcaa caagaaattt ttgcccttcc agcaattcgg gagggatatt     1740

gccgatacta ccgatgctgt acgggacccc cagacactcg aaatattgga cataaccccg     1800

tgctcttttg gaggggtctc tgtgattacc ccgggtacga acacgagtaa tcaggtggca     1860

gtgctttatc agggagtgaa ttgcacagaa gtaccagtcg cgatccatgc cgaccagctc     1920

acgccgacct ggagggttta tagtacgggt agtaacgttt tccaaacacg ggccggttgt     1980

ctcatcgggg cagagtacgt taataacagc tatgaatgtg atatacccat aggtgccggg     2040

atttgtgctt cttatcaaac ccaaaccaat agcagaagcg ttgcgtcaca gtctataatc     2100

gcctatacga tgagcctcgg agcggaaaac tcagttgcct actccaacaa tagcattgct     2160

atcccaacga acttcactat tagcgtaacc acggagatcc ttccagttag catgacaaaa     2220

actagcgtcg attgcactat gtatatttgc ggcgacagta cagagtgtag taatttgctc     2280

ctgcagtacg ggtctttctg cacccaattg aaccgagcac tgactggcat cgccgtggaa     2340

caagacaaaa acacgcaaga agtatttgcg caagtcaagc agatttacaa gactcccccg     2400

atcaaagact ttggcggatt taattttagc cagatactcc ccgatccatc taaaccatca     2460

aaacggtcct ttatagaaga tctcttgttc aataaagtga cactcgcgga cgcgggcttt     2520

atcaaacagt atggggactg ccttggagat atagctgcga gggacttgat ttgcgcccag     2580

aaattcaacg ggctgacggt tctgccgccg ctcttgacag acgaaatgat tgcacagtat     2640

acgagtgcct tgctggcagg gactatcact tccggttgga ccttcggcgc aggagcagcg     2700

ctccagatcc cattcgctat gcaaatggct taccgattca acggaattgg cgtcacacag     2760

aacgtgcttt acgagaatca aaagctgatt gccaatcaat tcaactcagc gattggcaaa     2820

atacaagata gtctctcttc aactgcatcc gcgctcggta agttgcagga cgtagtcaat     2880

cagaacgcac aggccctgaa cacgcttgtt aaacaactgt cttcaaactt cggtgcaata     2940

agttccgtac ttaatgatat cttgtcaagg ttggataagg tcgaagctga ggtacaaatc     3000

gaccgcctta taacaggcag actccaatcc ctgcagacat acgtgaccca gcaactcatt     3060

agggcagccg agatcagagc aagtgccaac ctcgctgcta ttaaaatgtc tgaatgcgtt     3120

ttggggcaat ctaagcgggt tgatttctgc ggtaagggat accacttgat gtcctttcct     3180

cagtccgctc ctcatggggt agtatttctt catgttacat atgtaccagc acaagagaaa     3240

aattttacta ctgccccggc catatgccat gatggcaaag cgcacttccc tcgggagggg     3300

gtttttgtgt ctaatggaac ccactggttc gtgactcagc ggaatttcta tgaaccccag     3360

attataacta ctgacaacac tttcgtttct ggaaactgcg atgtagtaat aggcatagta     3420

aataatacag tatatgatcc cttgcaacca gaattggact cttttaaaga agagctcgac     3480

aaatatttta aaaaccatac atctccagac gttgatcttg gagacatctc tgggataaac     3540

gctagcttcg taaacataca aaaagaaatc gataggctta acgaggtcgc aaaaaatctt     3600

aatgaaagtc ttatcgattt gcaagagctt ggaaagtatg agcagtatat caaatggcct     3660

gtaggtatta tagccgggct cgtgttgttg ggtgcagtaa tcacaggagc cgtcgtggca     3720

gcggttatgt ggagacggaa atcttcagac cgcaaaggtg gtagttacac tcaagcggct     3780

tccagtgatt ctgcccaggg ctccgacgta tccctcactg cgtgtaaggt ttcacgactg     3840

gaggaagaac tgcgccgacg cctgactgaa tga                                  3873


<210>  64
<211>  1288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brazil Spike S1+S2 ECD_HLA

<400>  64

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Phe Thr Asn Arg Thr Gln 
            20                  25                  30          


Leu Pro Ser Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Tyr Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro 
    1205                 1210                 1215             


Val Gly  Ile Ile Ala Gly Leu  Val Leu Leu Gly Ala  Val Ile Thr 
    1220                 1225                 1230             


Gly Ala  Val Val Ala Ala Val  Met Trp Arg Arg Lys  Ser Ser Asp 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ser Tyr Thr  Gln Ala Ala Ser Ser  Asp Ser Ala 
    1250                 1255                 1260             


Gln Gly  Ser Asp Val Ser Leu  Thr Ala Cys Lys Val  Ser Arg Leu 
    1265                 1270                 1275             


Glu Glu  Glu Leu Arg Arg Arg  Leu Thr Glu 
    1280                 1285             


<210>  65
<211>  3870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Delta Spike S1+S2 ECD_HLA 

<400>  65
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt taatcttaca accagaactc aattaccccc tgcatacact      120

aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat      180

tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat      240

gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt      300

gtttattttg cttccattga gaagtctaac ataataagag gctggatttt tggtactact      360

ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa      420

gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac      480

aaaagttgga tgaaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa      540

tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt      600

agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct      660

attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg      720

ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg      780

actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat      840

cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta      900

gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa      960

aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt     1020

cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct     1080

gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat     1140

aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat     1200

ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa     1260

atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt     1320

acaggctgcg ttatagcttg gaattctaac aaacttgatt ctaaggttgg tggtaattat     1380

aattaccgct atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca     1440

actgaaatct atcaggccgg tagcacacct tgtaatggtg ttcagggttt taattgttac     1500

tttcctttac aatcatatgg tttccaaccc acttatggtg ttggttacca accatacaga     1560

gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag     1620

tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca     1680

ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt     1740

gatgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca     1800

tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct     1860

gttctttatc agggtgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt     1920

actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt     1980

ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt     2040

atatgcgcta gttatcagac tcagactaat tctagtgtag ctagtcaatc catcattgcc     2100

tacactatgt cacttggtgc agaaaattca gttgcttact ctaataactc tattgccata     2160

cccattaatt ttactattag tgttaccaca gaaattctac cagtgtctat gaccaagaca     2220

tcagtagatt gtacaatgta catttgtggt gattcaactg aatgcagcaa tcttttgttg     2280

caatatggca gtttttgtac acaattaaac cgtgctttaa ctggaatagc tgttgaacaa     2340

gacaaaaaca cccaagaagt ttttgcacaa gtcaaacaaa tttacaaaac accaccaatt     2400

aaagattttg gtggttttaa tttttcacaa atattaccag atccatcaaa accaagcaag     2460

aggtcattta ttgaagatct acttttcaac aaagtgacac ttgcagatgc tggcttcatc     2520

aaacaatatg gtgattgcct tggtgatatt gctgctagag acctcatttg tgcacaaaag     2580

tttaacggcc ttactgtttt gccacctttg ctcacagatg aaatgattgc tcaatacact     2640

tctgcactgt tagcgggtac aatcacttct ggttggacct ttggtgcagg tgctgcatta     2700

caaataccat ttgctatgca aatggcttat aggtttaatg gtattggagt tacacagaat     2760

gttctctatg agaaccaaaa attgattgcc aaccaattta atagtgctat tggcaaaatt     2820

caagactcac tttcttccac agcaagtgca cttggaaaac ttcaagatgt ggtcaaccaa     2880

aatgcacaag ctttaaacac gcttgttaaa caacttagct ccaattttgg tgcaatttca     2940

agtgttttaa atgatatcct tgcacgtctt gacaaagttg aggctgaagt gcaaattgat     3000

aggttgatca caggcagact tcaaagtttg cagacatatg tgactcaaca attaattaga     3060

gctgcagaaa tcagagcttc tgctaatctt gctgctacta aaatgtcaga gtgtgtactt     3120

ggacaatcaa aaagagttga tttttgtgga aagggctatc atcttatgtc cttccctcag     3180

tcagcacctc atggtgtagt cttcttgcat gtgacttatg tccctgcaca cgaaaagaac     3240

ttcacaactg ctcctgccat ttgtcatgat ggaaaagcac actttcctcg tgaaggtgtc     3300

tttgtttcaa atggcacaca ctggtttgta acacaaagga atttttatga accacaaatc     3360

attactacac acaacacatt tgtgtctggt aactgtgatg ttgtaatagg aattgtcaac     3420

aacacagttt atgatccttt gcaacctgaa ttagactcat tcaaggagga gttagataaa     3480

tattttaaga atcatacatc accagatgtt gatttaggtg acatctctgg cattaatgct     3540

tcagttgtaa acattcaaaa agaaattgac cgcctcaatg aggttgccaa gaatttaaat     3600

gaatctctca tcgatctcca agaacttgga aagtatgagc agtatataaa atggccagta     3660

ggtattatag ccgggctcgt gttgttgggt gcagtaatca caggagccgt cgtggcagcg     3720

gttatgtgga gacggaaatc ttcagaccgc aaaggtggta gttacactca agcggcttcc     3780

agtgattctg cccagggctc cgacgtatcc ctcactgcgt gtaaggtttc acgactggag     3840

gaagaactgc gccgacgcct gactgaataa                                      3870


<210>  66
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta Spike S1+S2 ECD_HLA

<400>  66

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Lys Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Lys Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Gln Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
    690                 695                 700                 


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile 
705                 710                 715                 720 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
                725                 730                 735     


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
            740                 745                 750         


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
        755                 760                 765             


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
    770                 775                 780                 


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
785                 790                 795                 800 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
                805                 810                 815     


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
            820                 825                 830         


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
        835                 840                 845             


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
    850                 855                 860                 


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
865                 870                 875                 880 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
                885                 890                 895     


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
            900                 905                 910         


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
        915                 920                 925             


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
    930                 935                 940                 


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
945                 950                 955                 960 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
                965                 970                 975     


Ile Ser Ser Val Leu Asn Asp Ile Leu Ala Arg Leu Asp Lys Val Glu 
            980                 985                 990         


Ala Glu Val Gln Ile Asp Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu 
        995                 1000                 1005             


Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
    1010                 1015                 1020             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1025                 1030                 1035             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1040                 1045                 1050             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1055                 1060                 1065             


Val Thr  Tyr Val Pro Ala His  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1070                 1075                 1080             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1085                 1090                 1095             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1100                 1105                 1110             


Tyr Glu  Pro Gln Ile Ile Thr  Thr His Asn Thr Phe  Val Ser Gly 
    1115                 1120                 1125             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1130                 1135                 1140             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1145                 1150                 1155             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1160                 1165                 1170             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1175                 1180                 1185             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1190                 1195                 1200             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Val 
    1205                 1210                 1215             


Gly Ile  Ile Ala Gly Leu Val  Leu Leu Gly Ala Val  Ile Thr Gly 
    1220                 1225                 1230             


Ala Val  Val Ala Ala Val Met  Trp Arg Arg Lys Ser  Ser Asp Arg 
    1235                 1240                 1245             


Lys Gly  Gly Ser Tyr Thr Gln  Ala Ala Ser Ser Asp  Ser Ala Gln 
    1250                 1255                 1260             


Gly Ser  Asp Val Ser Leu Thr  Ala Cys Lys Val Ser  Arg Leu Glu 
    1265                 1270                 1275             


Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1280                 1285         


<210>  67
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD74 cytoplasmic domain

<400>  67

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg 
        35                  40                  45      


<210>  68
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA signal sequence

<400>  68

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala 
            20                  


<210>  69
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding HLA signal sequence

<400>  69
atggcggtca tggcaccacg cacgctcctt cttttgttgt ctggtgccct tgcactcacc       60

caaacgtggg ca                                                           72


<210>  70
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA transmembrane domain

<400>  70

Trp Met Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu 
1               5                   10                  15      


Val Leu Gly Ala Ile Ile Gly Val 
            20                  


<210>  71
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding HLA transmembrane domain

<400>  71
tggatggtgg ctgcggtcgt ggcaggtacg attgtggctg gcctcctcgt tcttggggct       60

attatcggtg ta                                                           72


<210>  72
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA cytoplasmic domain

<400>  72

Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala Val Ile Thr Gly 
1               5                   10                  15      


Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser Ser Asp Arg Lys 
            20                  25                  30          


Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser 
        35                  40                  45              


Asp Val Ser Leu Thr Ala Cys Lys Val 
    50                  55          


<210>  73
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding HLA cytoplasmic domain

<400>  73
gtaggtatta tagccgggct cgtgttgttg ggtgcagtaa tcacaggagc cgtcgtggca       60

gcggttatgt ggagacggaa atcttcagac cgcaaaggtg gtagttacac tcaagcggct      120

tccagtgatt ctgcccaggg ctccgacgta tccctcactg cgtgtaaggt t               171


<210>  74
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  targeting moiety

<400>  74

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val 
65                  70  


<210>  75
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD74 cytoplasmic domain

<400>  75
caccggagga gatccagaag ttgcagagaa gaccaaaatc cagtaatgga tgaccaaagg       60

gatcttattt ctaataacga gcagctccct atgctgggac gccgaccggg ggcacccgaa      120

tcaaagtgca gtcgc                                                       135


<210>  76
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein

<400>  76

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
                245                 250                 255     


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
            260                 265                 270         


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
        275                 280                 285             


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
    290                 295                 300                 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
305                 310                 315                 320 


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
                325                 330                 335     


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
            340                 345                 350         


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
        355                 360                 365             


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
    370                 375                 380                 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
385                 390                 395                 400 


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                405                 410                 415     


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
            420                 425                 430         


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn 
465                 470                 475                 480 


Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Asn Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Ala Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1190                 1195                 1200             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1205                 1210                 1215             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1220                 1225                 1230             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1235                 1240                 1245             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr Ser Arg  Leu Glu Glu 
    1250                 1255                 1260             


Glu Leu  Arg Arg Arg Leu Thr  Glu 
    1265                 1270     


<210>  77
<211>  1197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike protein extracellular domain

<400>  77

Met Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser 
            20                  25                  30          


Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val 
        35                  40                  45              


Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys Arg 
    50                  55                  60                  


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
65                  70                  75                  80  


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
                85                  90                  95      


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
            100                 105                 110         


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly 
        115                 120                 125             


Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg 
    130                 135                 140                 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
145                 150                 155                 160 


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser 
                165                 170                 175     


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
            180                 185                 190         


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
        195                 200                 205             


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
    210                 215                 220                 


Gln Thr Leu Leu Ala Leu His Asn Ser Ser Ser Gly Trp Thr Ala Gly 
225                 230                 235                 240 


Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu 
                245                 250                 255     


Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu 
            260                 265                 270         


Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu 
        275                 280                 285             


Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser 
    290                 295                 300                 


Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
305                 310                 315                 320 


Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg 
                325                 330                 335     


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser 
            340                 345                 350         


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
        355                 360                 365             


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
    370                 375                 380                 


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
385                 390                 395                 400 


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
                405                 410                 415     


Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln Tyr 
            420                 425                 430         


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
        435                 440                 445             


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly 
    450                 455                 460                 


Phe Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr 
465                 470                 475                 480 


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
                485                 490                 495     


Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu 
            500                 505                 510         


Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr 
        515                 520                 525             


Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe 
    530                 535                 540                 


Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr 
545                 550                 555                 560 


Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val 
                565                 570                 575     


Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln 
            580                 585                 590         


Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu 
        595                 600                 605             


Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr 
    610                 615                 620                 


Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser Tyr Glu 
625                 630                 635                 640 


Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln 
                645                 650                 655     


Thr Asn Ser Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
            660                 665                 670         


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
        675                 680                 685             


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
    690                 695                 700                 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
705                 710                 715                 720 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
                725                 730                 735     


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
            740                 745                 750         


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
        755                 760                 765             


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
    770                 775                 780                 


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
785                 790                 795                 800 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
                805                 810                 815     


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Asn Val Leu 
            820                 825                 830         


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
        835                 840                 845             


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
    850                 855                 860                 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
865                 870                 875                 880 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
                885                 890                 895     


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
            900                 905                 910         


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
        915                 920                 925             


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
    930                 935                 940                 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala 
945                 950                 955                 960 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
                965                 970                 975     


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
            980                 985                 990         


Ala Asn Leu Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
        995                 1000                 1005             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1010                 1015                 1020             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1025                 1030                 1035             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1040                 1045                 1050             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1055                 1060                 1065             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1070                 1075                 1080             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1085                 1090                 1095             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1100                 1105                 1110             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1115                 1120                 1125             


Asn His  Thr Ser Pro Asp Val  Asp Leu Ala Asp Ile  Ser Gly Ile 
    1130                 1135                 1140             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1145                 1150                 1155             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1160                 1165                 1170             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Ser  Arg Leu Glu 
    1175                 1180                 1185             


Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1190                 1195         


<210>  78
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein

<400>  78
gccaccatgt ttgtgttcct ggtccttctc ccgcttgtaa gctcccaatg cgttaacttt       60

actactcgga cccaactccc gccggcgtac actaactctt ttacccgggg cgtctattat      120

cctgacaaag tgtttcgatc atctgttttg cactccaccc aagatctctt tcttccattt      180

ttcagcaacg ttacgtggtt ccacgcgata catgttagtg gtactaatgt tataaagaga      240

tttgacaacc ctgtgctccc gtttaacgat ggggtctatt tcgcttccac tgagaagtcc      300

aacattattc gcggttggat cttcggcacc acactcgatt caaaaaccca aagcttgctc      360

atagttaaca acgccacaaa cgtagtcatt aaagtgtgcg aatttcagtt ttgtaactat      420

ccctttttgg gcgtctacta tcacaagaac aacaagtcct ggatggaatc tgagtttcgg      480

gtctacagtt cagccaacaa ctgtacgttt gagtacgtta gccagccctt tctgatggat      540

cttgaaggga agcaaggaaa tttcaagaat ctttccgagt ttgtgtttaa aaatatagac      600

ggatatttca agatatacag taagcacaca ccgatcaatt tggtacggga tttgccgcaa      660

ggattttccg cccttgagcc ccttgtagat ctccccatcg gaattaacat aaccaggttt      720

caaacactgc tggcgctcca caactcatcc agtgggtgga ccgccggagc agccgcatac      780

tacgtggggt atctccagcc cagaacgttt ctcctcaagt ataatgaaaa cgggaccatc      840

accgacgcgg ttgattgtgc actcgatccc ctcagcgaga caaagtgcac acttaaatca      900

tttaccgtcg agaaggggat ctaccaaaca tccaactttc gggtgcagcc taccgagtca      960

atagtacggt ttcctaacat caccaatttg tgcccttttg gggaagtatt taatgcaacc     1020

cggtttgcga gcgtatacgc ttggaaccga aaacggataa gtaattgtgt tgcagattat     1080

tctgtgctct ataactcagc ttccttctcc acctttaagt gttacggagt atctccgaca     1140

aaattgaatg atctttgttt tacgaatgtt tacgctgact catttgttat ccgaggtgac     1200

gaagtgcgcc agatagcccc cggtcaaaca ggcaaaattg ctgattataa ctacaagttg     1260

cccgatgact tcacggggtg tgttattgca tggaattcaa ataatcttga tagtaaggta     1320

gggggtaact ataattacca atatcgcttg ttccgcaaat ccaatctgaa acccttcgaa     1380

agggatatca gtaccgagat ttatcaagcc ggctccacac cttgtaacgg agtaaaaggt     1440

tttaactgtt attccccact gcagagttac ggctttcaac ccacatacgg ggtgggatat     1500

cagccctatc gcgttgtggt cttgtccttt gaacttctcc acgcccctgc aacagtttgt     1560

ggtcctaaaa agagtacaaa tctggtaaaa aataagtgcg tcaactttaa cttcaacgga     1620

ctgactggta ccggggtcct cactgagagc aacaagaaat ttttgccctt ccagcaattc     1680

gggagggata ttgccgatac taccgatgct gtacgggacc cccagacact cgaaatattg     1740

gacataaccc cgtgctcttt tggaggggtc tctgtgatta ccccgggtac gaacacgagt     1800

aatcaggtgg cagtgcttta tcagggagtg aattgcacag aagtaccagt cgcgatccat     1860

gccgaccagc tcacgccgac ctggagggtt tatagtacgg gtagtaacgt tttccaaaca     1920

cgggccggtt gtctcatcgg ggcagagtac gttaataaca gctatgaatg tgatataccc     1980

ataggtgccg ggatttgtgc ttcttatcaa acccaaacca atagctcaca gtctataatc     2040

gcctatacga tgagcctcgg agcggaaaac tcagttgcct actccaacaa tagcattgct     2100

atcccaacga acttcactat tagcgtaacc acggagatcc ttccagttag catgacaaaa     2160

actagcgtcg attgcactat gtatatttgc ggcgacagta cagagtgtag taatttgctc     2220

ctgcagtacg ggtctttctg cacccaattg aaccgagcac tgactggcat cgccgtggaa     2280

caagacaaaa acacgcaaga agtatttgcg caagtcaagc agatttacaa gactcccccg     2340

atcaaagact ttggcggatt taattttagc cagatactcc ccgatccatc taaaccatca     2400

aaacggtcct ttatagaaga tctcttgttc aataaagtga cactcgcgga cgcgggcttt     2460

atcaaacagt atggggactg ccttggagat atagctgcga gggacttgat ttgcgcccag     2520

aaattcaacg ggctgaatgt tctgccgccg ctcttgacag acgaaatgat tgcacagtat     2580

acgagtgcct tgctggcagg gactatcact tccggttgga ccttcggcgc aggagcagcg     2640

ctccagatcc cattcgctat gcaaatggct taccgattca acggaattgg cgtcacacag     2700

aacgtgcttt acgagaatca aaagctgatt gccaatcaat tcaactcagc gattggcaaa     2760

atacaagata gtctctcttc aactgcatcc gcgctcggta agttgcagga cgtagtcaat     2820

cagaacgcac aggccctgaa cacgcttgtt aaacaactgt cttcaaactt cggtgcaata     2880

agttccgtac ttaatgatat cttgtcaagg ttggataagg tcgaagctga ggtacaaatc     2940

gaccgcctta taacaggcag actccaatcc ctgcagacat acgtgaccca gcaactcatt     3000

agggcagccg agatcagagc aagtgccaac ctcgctgcta caaaaatgtc tgaatgcgtt     3060

ttggggcaat ctaagcgggt tgatttctgc ggtaagggat accacttgat gtcctttcct     3120

cagtccgctc ctcatggggt agtatttctt catgttacat atgtaccagc acaagagaaa     3180

aattttacta ctgccccggc catatgccat gatggcaaag cgcacttccc tcgggagggg     3240

gtttttgtgt ctaatggaac ccactggttc gtgactcagc ggaatttcta tgaaccccag     3300

attataacta ctgacaacac tttcgtttct ggaaactgcg atgtagtaat aggcatagta     3360

aataatacag tatatgatcc cttgcaacca gaattggact cttttaaaga agagctcgac     3420

aaatatttta aaaaccatac atctccagac gttgatcttg ctgacatctc tgggataaac     3480

gctagcgtag taaacataca aaaagaaatc gataggctta acgaggtcgc aaaaaatctt     3540

aatgaaagtc ttatcgattt gcaagagctt ggaaagtatg agcagtatat caaatggcct     3600

tggtatatat ggctgggatt tattgctggt ctcatagcca tagttatggt gacaataatg     3660

ctgtgctgta tgacgtcatg ttgttcctgc ctgaaagggt gctgtagttg tgggagttgt     3720

tgcaagtttg acgaggacga ctcagagccc gttttgaaag gtgtgaaact tcattataca     3780

tcacgactgg aggaagaact gcgccgacgc ctgactgaat ga                        3822


<210>  79
<211>  3600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a spike protein extracellular domain

<400>  79
gccaccatgg ttaactttac tactcggacc caactcccgc cggcgtacac taactctttt       60

acccggggcg tctattatcc tgacaaagtg tttcgatcat ctgttttgca ctccacccaa      120

gatctctttc ttccattttt cagcaacgtt acgtggttcc acgcgataca tgttagtggt      180

actaatgtta taaagagatt tgacaaccct gtgctcccgt ttaacgatgg ggtctatttc      240

gcttccactg agaagtccaa cattattcgc ggttggatct tcggcaccac actcgattca      300

aaaacccaaa gcttgctcat agttaacaac gccacaaacg tagtcattaa agtgtgcgaa      360

tttcagtttt gtaactatcc ctttttgggc gtctactatc acaagaacaa caagtcctgg      420

atggaatctg agtttcgggt ctacagttca gccaacaact gtacgtttga gtacgttagc      480

cagccctttc tgatggatct tgaagggaag caaggaaatt tcaagaatct ttccgagttt      540

gtgtttaaaa atatagacgg atatttcaag atatacagta agcacacacc gatcaatttg      600

gtacgggatt tgccgcaagg attttccgcc cttgagcccc ttgtagatct ccccatcgga      660

attaacataa ccaggtttca aacactgctg gcgctccaca actcatccag tgggtggacc      720

gccggagcag ccgcatacta cgtggggtat ctccagccca gaacgtttct cctcaagtat      780

aatgaaaacg ggaccatcac cgacgcggtt gattgtgcac tcgatcccct cagcgagaca      840

aagtgcacac ttaaatcatt taccgtcgag aaggggatct accaaacatc caactttcgg      900

gtgcagccta ccgagtcaat agtacggttt cctaacatca ccaatttgtg cccttttggg      960

gaagtattta atgcaacccg gtttgcgagc gtatacgctt ggaaccgaaa acggataagt     1020

aattgtgttg cagattattc tgtgctctat aactcagctt ccttctccac ctttaagtgt     1080

tacggagtat ctccgacaaa attgaatgat ctttgtttta cgaatgttta cgctgactca     1140

tttgttatcc gaggtgacga agtgcgccag atagcccccg gtcaaacagg caaaattgct     1200

gattataact acaagttgcc cgatgacttc acggggtgtg ttattgcatg gaattcaaat     1260

aatcttgata gtaaggtagg gggtaactat aattaccaat atcgcttgtt ccgcaaatcc     1320

aatctgaaac ccttcgaaag ggatatcagt accgagattt atcaagccgg ctccacacct     1380

tgtaacggag taaaaggttt taactgttat tccccactgc agagttacgg ctttcaaccc     1440

acatacgggg tgggatatca gccctatcgc gttgtggtct tgtcctttga acttctccac     1500

gcccctgcaa cagtttgtgg tcctaaaaag agtacaaatc tggtaaaaaa taagtgcgtc     1560

aactttaact tcaacggact gactggtacc ggggtcctca ctgagagcaa caagaaattt     1620

ttgcccttcc agcaattcgg gagggatatt gccgatacta ccgatgctgt acgggacccc     1680

cagacactcg aaatattgga cataaccccg tgctcttttg gaggggtctc tgtgattacc     1740

ccgggtacga acacgagtaa tcaggtggca gtgctttatc agggagtgaa ttgcacagaa     1800

gtaccagtcg cgatccatgc cgaccagctc acgccgacct ggagggttta tagtacgggt     1860

agtaacgttt tccaaacacg ggccggttgt ctcatcgggg cagagtacgt taataacagc     1920

tatgaatgtg atatacccat aggtgccggg atttgtgctt cttatcaaac ccaaaccaat     1980

agctcacagt ctataatcgc ctatacgatg agcctcggag cggaaaactc agttgcctac     2040

tccaacaata gcattgctat cccaacgaac ttcactatta gcgtaaccac ggagatcctt     2100

ccagttagca tgacaaaaac tagcgtcgat tgcactatgt atatttgcgg cgacagtaca     2160

gagtgtagta atttgctcct gcagtacggg tctttctgca cccaattgaa ccgagcactg     2220

actggcatcg ccgtggaaca agacaaaaac acgcaagaag tatttgcgca agtcaagcag     2280

atttacaaga ctcccccgat caaagacttt ggcggattta attttagcca gatactcccc     2340

gatccatcta aaccatcaaa acggtccttt atagaagatc tcttgttcaa taaagtgaca     2400

ctcgcggacg cgggctttat caaacagtat ggggactgcc ttggagatat agctgcgagg     2460

gacttgattt gcgcccagaa attcaacggg ctgaatgttc tgccgccgct cttgacagac     2520

gaaatgattg cacagtatac gagtgccttg ctggcaggga ctatcacttc cggttggacc     2580

ttcggcgcag gagcagcgct ccagatccca ttcgctatgc aaatggctta ccgattcaac     2640

ggaattggcg tcacacagaa cgtgctttac gagaatcaaa agctgattgc caatcaattc     2700

aactcagcga ttggcaaaat acaagatagt ctctcttcaa ctgcatccgc gctcggtaag     2760

ttgcaggacg tagtcaatca gaacgcacag gccctgaaca cgcttgttaa acaactgtct     2820

tcaaacttcg gtgcaataag ttccgtactt aatgatatct tgtcaaggtt ggataaggtc     2880

gaagctgagg tacaaatcga ccgccttata acaggcagac tccaatccct gcagacatac     2940

gtgacccagc aactcattag ggcagccgag atcagagcaa gtgccaacct cgctgctaca     3000

aaaatgtctg aatgcgtttt ggggcaatct aagcgggttg atttctgcgg taagggatac     3060

cacttgatgt cctttcctca gtccgctcct catggggtag tatttcttca tgttacatat     3120

gtaccagcac aagagaaaaa ttttactact gccccggcca tatgccatga tggcaaagcg     3180

cacttccctc gggagggggt ttttgtgtct aatggaaccc actggttcgt gactcagcgg     3240

aatttctatg aaccccagat tataactact gacaacactt tcgtttctgg aaactgcgat     3300

gtagtaatag gcatagtaaa taatacagta tatgatccct tgcaaccaga attggactct     3360

tttaaagaag agctcgacaa atattttaaa aaccatacat ctccagacgt tgatcttgct     3420

gacatctctg ggataaacgc tagcgtagta aacatacaaa aagaaatcga taggcttaac     3480

gaggtcgcaa aaaatcttaa tgaaagtctt atcgatttgc aagagcttgg aaagtatgag     3540

cagtatatca aatggccttc acgactggag gaagaactgc gccgacgcct gactgaatga     3600


<210>  80
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA cytoplasmic domain

<400>  80

Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala 
1               5                   10                  15      


Ser Ser Asp Ser Ala Gln Gly Ser 
            20                  


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of HLA cytoplasmic domain

<400>  81

Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala 
1               5                   10                  15      


Val 
    


<210>  82
<211>  3807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a Lambda Spike S1+S2ECD_CD74CD+HLATM

<400>  82
gccaccatgc accggaggag atccagaagt tgcagagaag accaaaatcc agtaatggat       60

gaccaaaggg atcttatttc taataacgag cagctcccta tgctgggacg ccgaccgggg      120

gcacccgaat caaagtgcag tcgctggatg gtggctgcgg tcgtggcagg tacgattgtg      180

gctggcctcc tcgttcttgg ggctattatc ggtgtagtta actttactac tcggacccaa      240

ctcccgccgg cgtacactaa ctcttttacc cggggcgtct attatcctga caaagtgttt      300

cgatcatctg ttttgcactc cacccaagat ctctttcttc catttttcag caacgttacg      360

tggttccacg cgatacatgt tagtggtact aatgttataa agagatttga caaccctgtg      420

ctcccgttta acgatggggt ctatttcgct tccactgaga agtccaacat tattcgcggt      480

tggatcttcg gcaccacact cgattcaaaa acccaaagct tgctcatagt taacaacgcc      540

acaaacgtag tcattaaagt gtgcgaattt cagttttgta actatccctt tttgggcgtc      600

tactatcaca agaacaacaa gtcctggatg gaatctgagt ttcgggtcta cagttcagcc      660

aacaactgta cgtttgagta cgttagccag ccctttctga tggatcttga agggaagcaa      720

ggaaatttca agaatctttc cgagtttgtg tttaaaaata tagacggata tttcaagata      780

tacagtaagc acacaccgat caatttggta cgggatttgc cgcaaggatt ttccgccctt      840

gagccccttg tagatctccc catcggaatt aacataacca ggtttcaaac actgctggcg      900

ctccacaact catccagtgg gtggaccgcc ggagcagccg catactacgt ggggtatctc      960

cagcccagaa cgtttctcct caagtataat gaaaacggga ccatcaccga cgcggttgat     1020

tgtgcactcg atcccctcag cgagacaaag tgcacactta aatcatttac cgtcgagaag     1080

gggatctacc aaacatccaa ctttcgggtg cagcctaccg agtcaatagt acggtttcct     1140

aacatcacca atttgtgccc ttttggggaa gtatttaatg caacccggtt tgcgagcgta     1200

tacgcttgga accgaaaacg gataagtaat tgtgttgcag attattctgt gctctataac     1260

tcagcttcct tctccacctt taagtgttac ggagtatctc cgacaaaatt gaatgatctt     1320

tgttttacga atgtttacgc tgactcattt gttatccgag gtgacgaagt gcgccagata     1380

gcccccggtc aaacaggcaa aattgctgat tataactaca agttgcccga tgacttcacg     1440

gggtgtgtta ttgcatggaa ttcaaataat cttgatagta aggtaggggg taactataat     1500

taccaatatc gcttgttccg caaatccaat ctgaaaccct tcgaaaggga tatcagtacc     1560

gagatttatc aagccggctc cacaccttgt aacggagtaa aaggttttaa ctgttattcc     1620

ccactgcaga gttacggctt tcaacccaca tacggggtgg gatatcagcc ctatcgcgtt     1680

gtggtcttgt cctttgaact tctccacgcc cctgcaacag tttgtggtcc taaaaagagt     1740

acaaatctgg taaaaaataa gtgcgtcaac tttaacttca acggactgac tggtaccggg     1800

gtcctcactg agagcaacaa gaaatttttg cccttccagc aattcgggag ggatattgcc     1860

gatactaccg atgctgtacg ggacccccag acactcgaaa tattggacat aaccccgtgc     1920

tcttttggag gggtctctgt gattaccccg ggtacgaaca cgagtaatca ggtggcagtg     1980

ctttatcagg gagtgaattg cacagaagta ccagtcgcga tccatgccga ccagctcacg     2040

ccgacctgga gggtttatag tacgggtagt aacgttttcc aaacacgggc cggttgtctc     2100

atcggggcag agtacgttaa taacagctat gaatgtgata tacccatagg tgccgggatt     2160

tgtgcttctt atcaaaccca aaccaatagc tcacagtcta taatcgccta tacgatgagc     2220

ctcggagcgg aaaactcagt tgcctactcc aacaatagca ttgctatccc aacgaacttc     2280

actattagcg taaccacgga gatccttcca gttagcatga caaaaactag cgtcgattgc     2340

actatgtata tttgcggcga cagtacagag tgtagtaatt tgctcctgca gtacgggtct     2400

ttctgcaccc aattgaaccg agcactgact ggcatcgccg tggaacaaga caaaaacacg     2460

caagaagtat ttgcgcaagt caagcagatt tacaagactc ccccgatcaa agactttggc     2520

ggatttaatt ttagccagat actccccgat ccatctaaac catcaaaacg gtcctttata     2580

gaagatctct tgttcaataa agtgacactc gcggacgcgg gctttatcaa acagtatggg     2640

gactgccttg gagatatagc tgcgagggac ttgatttgcg cccagaaatt caacgggctg     2700

aatgttctgc cgccgctctt gacagacgaa atgattgcac agtatacgag tgccttgctg     2760

gcagggacta tcacttccgg ttggaccttc ggcgcaggag cagcgctcca gatcccattc     2820

gctatgcaaa tggcttaccg attcaacgga attggcgtca cacagaacgt gctttacgag     2880

aatcaaaagc tgattgccaa tcaattcaac tcagcgattg gcaaaataca agatagtctc     2940

tcttcaactg catccgcgct cggtaagttg caggacgtag tcaatcagaa cgcacaggcc     3000

ctgaacacgc ttgttaaaca actgtcttca aacttcggtg caataagttc cgtacttaat     3060

gatatcttgt caaggttgga taaggtcgaa gctgaggtac aaatcgaccg ccttataaca     3120

ggcagactcc aatccctgca gacatacgtg acccagcaac tcattagggc agccgagatc     3180

agagcaagtg ccaacctcgc tgctacaaaa atgtctgaat gcgttttggg gcaatctaag     3240

cgggttgatt tctgcggtaa gggataccac ttgatgtcct ttcctcagtc cgctcctcat     3300

ggggtagtat ttcttcatgt tacatatgta ccagcacaag agaaaaattt tactactgcc     3360

ccggccatat gccatgatgg caaagcgcac ttccctcggg agggggtttt tgtgtctaat     3420

ggaacccact ggttcgtgac tcagcggaat ttctatgaac cccagattat aactactgac     3480

aacactttcg tttctggaaa ctgcgatgta gtaataggca tagtaaataa tacagtatat     3540

gatcccttgc aaccagaatt ggactctttt aaagaagagc tcgacaaata ttttaaaaac     3600

catacatctc cagacgttga tcttgctgac atctctggga taaacgctag cgtagtaaac     3660

atacaaaaag aaatcgatag gcttaacgag gtcgcaaaaa atcttaatga aagtcttatc     3720

gatttgcaag agcttggaaa gtatgagcag tatatcaaat ggccttcacg actggaggaa     3780

gaactgcgcc gacgcctgac tgaatga                                         3807


<210>  83
<211>  1266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  encodes Lambda Spike S1+S2ECD_CD74CD+HLATM

<400>  83

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Asn Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Trp Met 
        35                  40                  45              


Val Ala Ala Val Val Ala Gly Thr Ile Val Ala Gly Leu Leu Val Leu 
    50                  55                  60                  


Gly Ala Ile Ile Gly Val Val Asn Phe Thr Thr Arg Thr Gln Leu Pro 
65                  70                  75                  80  


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
                85                  90                  95      


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
            100                 105                 110         


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
        115                 120                 125             


Asn Val Ile Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
    130                 135                 140                 


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
145                 150                 155                 160 


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
                165                 170                 175     


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
            180                 185                 190         


Tyr Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
        195                 200                 205             


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
    210                 215                 220                 


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
225                 230                 235                 240 


Phe Lys Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
                245                 250                 255     


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
            260                 265                 270         


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
        275                 280                 285             


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Asn Ser Ser Ser 
    290                 295                 300                 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
305                 310                 315                 320 


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
                325                 330                 335     


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
            340                 345                 350         


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
        355                 360                 365             


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
    370                 375                 380                 


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
385                 390                 395                 400 


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
                405                 410                 415     


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
            420                 425                 430         


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
        435                 440                 445             


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
    450                 455                 460                 


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
465                 470                 475                 480 


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
                485                 490                 495     


Tyr Asn Tyr Gln Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
            500                 505                 510         


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
        515                 520                 525             


Asn Gly Val Lys Gly Phe Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly 
    530                 535                 540                 


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
545                 550                 555                 560 


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
                565                 570                 575     


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
            580                 585                 590         


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
        595                 600                 605             


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
    610                 615                 620                 


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
625                 630                 635                 640 


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
                645                 650                 655     


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
            660                 665                 670         


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
        675                 680                 685             


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
    690                 695                 700                 


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
705                 710                 715                 720 


Ser Tyr Gln Thr Gln Thr Asn Ser Ser Gln Ser Ile Ile Ala Tyr Thr 
                725                 730                 735     


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
            740                 745                 750         


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
        755                 760                 765             


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
    770                 775                 780                 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
785                 790                 795                 800 


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
                805                 810                 815     


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
            820                 825                 830         


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
        835                 840                 845             


Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn 
    850                 855                 860                 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
865                 870                 875                 880 


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
                885                 890                 895     


Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
            900                 905                 910         


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe 
        915                 920                 925             


Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr 
    930                 935                 940                 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
945                 950                 955                 960 


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
                965                 970                 975     


Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
            980                 985                 990         


Asn Gln Asn Ala Gln Ala Leu Asn  Thr Leu Val Lys Gln  Leu Ser Ser 
        995                 1000                 1005             


Asn Phe  Gly Ala Ile Ser Ser  Val Leu Asn Asp Ile  Leu Ser Arg 
    1010                 1015                 1020             


Leu Asp  Lys Val Glu Ala Glu  Val Gln Ile Asp Arg  Leu Ile Thr 
    1025                 1030                 1035             


Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
    1040                 1045                 1050             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1055                 1060                 1065             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1070                 1075                 1080             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1085                 1090                 1095             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1100                 1105                 1110             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1115                 1120                 1125             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1130                 1135                 1140             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1145                 1150                 1155             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1160                 1165                 1170             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1175                 1180                 1185             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1190                 1195                 1200             


Val Asp  Leu Ala Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1205                 1210                 1215             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1220                 1225                 1230             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1235                 1240                 1245             


Tyr Ile  Lys Trp Pro Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg 
    1250                 1255                 1260             


Leu Thr  Glu 
    1265     


<210>  84
<211>  3840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a Lambda Spike S1+S2ECD_HLA SS/TM/CD

<400>  84
gccaccatgg cggtcatggc accacgcacg ctccttcttt tgttgtctgg tgcccttgca       60

ctcacccaaa cgtgggcagt taactttact actcggaccc aactcccgcc ggcgtacact      120

aactctttta cccggggcgt ctattatcct gacaaagtgt ttcgatcatc tgttttgcac      180

tccacccaag atctctttct tccatttttc agcaacgtta cgtggttcca cgcgatacat      240

gttagtggta ctaatgttat aaagagattt gacaaccctg tgctcccgtt taacgatggg      300

gtctatttcg cttccactga gaagtccaac attattcgcg gttggatctt cggcaccaca      360

ctcgattcaa aaacccaaag cttgctcata gttaacaacg ccacaaacgt agtcattaaa      420

gtgtgcgaat ttcagttttg taactatccc tttttgggcg tctactatca caagaacaac      480

aagtcctgga tggaatctga gtttcgggtc tacagttcag ccaacaactg tacgtttgag      540

tacgttagcc agccctttct gatggatctt gaagggaagc aaggaaattt caagaatctt      600

tccgagtttg tgtttaaaaa tatagacgga tatttcaaga tatacagtaa gcacacaccg      660

atcaatttgg tacgggattt gccgcaagga ttttccgccc ttgagcccct tgtagatctc      720

cccatcggaa ttaacataac caggtttcaa acactgctgg cgctccacaa ctcatccagt      780

gggtggaccg ccggagcagc cgcatactac gtggggtatc tccagcccag aacgtttctc      840

ctcaagtata atgaaaacgg gaccatcacc gacgcggttg attgtgcact cgatcccctc      900

agcgagacaa agtgcacact taaatcattt accgtcgaga aggggatcta ccaaacatcc      960

aactttcggg tgcagcctac cgagtcaata gtacggtttc ctaacatcac caatttgtgc     1020

ccttttgggg aagtatttaa tgcaacccgg tttgcgagcg tatacgcttg gaaccgaaaa     1080

cggataagta attgtgttgc agattattct gtgctctata actcagcttc cttctccacc     1140

tttaagtgtt acggagtatc tccgacaaaa ttgaatgatc tttgttttac gaatgtttac     1200

gctgactcat ttgttatccg aggtgacgaa gtgcgccaga tagcccccgg tcaaacaggc     1260

aaaattgctg attataacta caagttgccc gatgacttca cggggtgtgt tattgcatgg     1320

aattcaaata atcttgatag taaggtaggg ggtaactata attaccaata tcgcttgttc     1380

cgcaaatcca atctgaaacc cttcgaaagg gatatcagta ccgagattta tcaagccggc     1440

tccacacctt gtaacggagt aaaaggtttt aactgttatt ccccactgca gagttacggc     1500

tttcaaccca catacggggt gggatatcag ccctatcgcg ttgtggtctt gtcctttgaa     1560

cttctccacg cccctgcaac agtttgtggt cctaaaaaga gtacaaatct ggtaaaaaat     1620

aagtgcgtca actttaactt caacggactg actggtaccg gggtcctcac tgagagcaac     1680

aagaaatttt tgcccttcca gcaattcggg agggatattg ccgatactac cgatgctgta     1740

cgggaccccc agacactcga aatattggac ataaccccgt gctcttttgg aggggtctct     1800

gtgattaccc cgggtacgaa cacgagtaat caggtggcag tgctttatca gggagtgaat     1860

tgcacagaag taccagtcgc gatccatgcc gaccagctca cgccgacctg gagggtttat     1920

agtacgggta gtaacgtttt ccaaacacgg gccggttgtc tcatcggggc agagtacgtt     1980

aataacagct atgaatgtga tatacccata ggtgccggga tttgtgcttc ttatcaaacc     2040

caaaccaata gctcacagtc tataatcgcc tatacgatga gcctcggagc ggaaaactca     2100

gttgcctact ccaacaatag cattgctatc ccaacgaact tcactattag cgtaaccacg     2160

gagatccttc cagttagcat gacaaaaact agcgtcgatt gcactatgta tatttgcggc     2220

gacagtacag agtgtagtaa tttgctcctg cagtacgggt ctttctgcac ccaattgaac     2280

cgagcactga ctggcatcgc cgtggaacaa gacaaaaaca cgcaagaagt atttgcgcaa     2340

gtcaagcaga tttacaagac tcccccgatc aaagactttg gcggatttaa ttttagccag     2400

atactccccg atccatctaa accatcaaaa cggtccttta tagaagatct cttgttcaat     2460

aaagtgacac tcgcggacgc gggctttatc aaacagtatg gggactgcct tggagatata     2520

gctgcgaggg acttgatttg cgcccagaaa ttcaacgggc tgaatgttct gccgccgctc     2580

ttgacagacg aaatgattgc acagtatacg agtgccttgc tggcagggac tatcacttcc     2640

ggttggacct tcggcgcagg agcagcgctc cagatcccat tcgctatgca aatggcttac     2700

cgattcaacg gaattggcgt cacacagaac gtgctttacg agaatcaaaa gctgattgcc     2760

aatcaattca actcagcgat tggcaaaata caagatagtc tctcttcaac tgcatccgcg     2820

ctcggtaagt tgcaggacgt agtcaatcag aacgcacagg ccctgaacac gcttgttaaa     2880

caactgtctt caaacttcgg tgcaataagt tccgtactta atgatatctt gtcaaggttg     2940

gataaggtcg aagctgaggt acaaatcgac cgccttataa caggcagact ccaatccctg     3000

cagacatacg tgacccagca actcattagg gcagccgaga tcagagcaag tgccaacctc     3060

gctgctacaa aaatgtctga atgcgttttg gggcaatcta agcgggttga tttctgcggt     3120

aagggatacc acttgatgtc ctttcctcag tccgctcctc atggggtagt atttcttcat     3180

gttacatatg taccagcaca agagaaaaat tttactactg ccccggccat atgccatgat     3240

ggcaaagcgc acttccctcg ggagggggtt tttgtgtcta atggaaccca ctggttcgtg     3300

actcagcgga atttctatga accccagatt ataactactg acaacacttt cgtttctgga     3360

aactgcgatg tagtaatagg catagtaaat aatacagtat atgatccctt gcaaccagaa     3420

ttggactctt ttaaagaaga gctcgacaaa tattttaaaa accatacatc tccagacgtt     3480

gatcttgctg acatctctgg gataaacgct agcgtagtaa acatacaaaa agaaatcgat     3540

aggcttaacg aggtcgcaaa aaatcttaat gaaagtctta tcgatttgca agagcttgga     3600

aagtatgagc agtatatcaa atggcctgta ggtattatag ccgggctcgt gttgttgggt     3660

gcagtaatca caggagccgt cgtggcagcg gttatgtgga gacggaaatc ttcagaccgc     3720

aaaggtggta gttacactca agcggcttcc agtgattctg cccagggctc cgacgtatcc     3780

ctcactgcgt gtaaggtttc acgactggag gaagaactgc gccgacgcct gactgaatga     3840


<210>  85
<211>  1277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lambda Spike S1+S2ECD_HLA SS/TM/CD

<400>  85

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Val Asn Phe Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Val Ile Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Tyr Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Asn Ser 
                245                 250                 255     


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
            260                 265                 270         


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
        275                 280                 285             


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
    290                 295                 300                 


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
305                 310                 315                 320 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
                325                 330                 335     


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            340                 345                 350         


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        355                 360                 365             


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    370                 375                 380                 


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
385                 390                 395                 400 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                405                 410                 415     


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            420                 425                 430         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        435                 440                 445             


Gly Asn Tyr Asn Tyr Gln Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    450                 455                 460                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
465                 470                 475                 480 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Ser Pro Leu Gln Ser 
                485                 490                 495     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            500                 505                 510         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        515                 520                 525             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    530                 535                 540                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
545                 550                 555                 560 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                565                 570                 575     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            580                 585                 590         


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
        595                 600                 605             


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
    610                 615                 620                 


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
625                 630                 635                 640 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
                645                 650                 655     


Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
            660                 665                 670         


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Ser Gln Ser Ile Ile Ala 
        675                 680                 685             


Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn 
    690                 695                 700                 


Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile 
705                 710                 715                 720 


Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile 
                725                 730                 735     


Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser 
            740                 745                 750         


Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln 
        755                 760                 765             


Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys 
    770                 775                 780                 


Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu 
785                 790                 795                 800 


Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu 
                805                 810                 815     


Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly 
            820                 825                 830         


Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        835                 840                 845             


Phe Asn Gly Leu Asn Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile 
    850                 855                 860                 


Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp 
865                 870                 875                 880 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                885                 890                 895     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            900                 905                 910         


Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile 
        915                 920                 925             


Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp 
    930                 935                 940                 


Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu 
945                 950                 955                 960 


Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser 
                965                 970                 975     


Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr 
            980                 985                 990         


Gly Arg Leu Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
        995                 1000                 1005             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1010                 1015                 1020             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1025                 1030                 1035             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1040                 1045                 1050             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1055                 1060                 1065             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1070                 1075                 1080             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1085                 1090                 1095             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1100                 1105                 1110             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1115                 1120                 1125             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1130                 1135                 1140             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1145                 1150                 1155             


Asp Leu  Ala Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1160                 1165                 1170             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1175                 1180                 1185             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1190                 1195                 1200             


Ile Lys  Trp Pro Val Gly Ile  Ile Ala Gly Leu Val  Leu Leu Gly 
    1205                 1210                 1215             


Ala Val  Ile Thr Gly Ala Val  Val Ala Ala Val Met  Trp Arg Arg 
    1220                 1225                 1230             


Lys Ser  Ser Asp Arg Lys Gly  Gly Ser Tyr Thr Gln  Ala Ala Ser 
    1235                 1240                 1245             


Ser Asp  Ser Ala Gln Gly Ser  Asp Val Ser Leu Thr  Ala Cys Lys 
    1250                 1255                 1260             


Val Ser  Arg Leu Glu Glu Glu  Leu Arg Arg Arg Leu  Thr Glu 
    1265                 1270                 1275         




