                         SEQUENCE LISTING

<110>  GEMINA LABORATORIES LTD.
 
<120>  DUAL-AFFINITY PROBES FOR ANALYTE DETECTION

<130>  ECSS-001/02WO 343014-2003

<150>  US 63/163,695
<151>  2021-03-19

<150>  US 63/076,918
<151>  2020-09-10

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      


Ser Gly Gly Gly 
            20  


<210>  2
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Met Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr 
1               5                   10                  15      


Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln 
            20                  25                  30          


Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala 
        35                  40                  45              


Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala Ser 
    50                  55                  60                  


Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys 
65                  70                  75                  80  


Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala 
                85                  90                  95      


Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu 
            100                 105                 110         


Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro 
        115                 120                 125             


Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys 
    130                 135                 140                 


Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala 
145                 150                 155                 160 


Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp 
                165                 170                 175     


Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe 
            180                 185                 190         


Thr Val Thr Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Ala Ser Gly Gly Gly 
    210                 215     


<210>  3
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His 
1               5                   10                  15      


Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys 
            20                  25                  30          


Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
        35                  40          


<210>  4
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His 
1               5                   10                  15      


Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys 
            20                  25                  30          


Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln 
        35                  40                  45              


Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr 
    50                  55                  60                  


Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly 
65                  70                  75                  80  


Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile 
                85                  90                  95      


Gln Ser 
        


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Trp Ala Gly Ala Lys Arg Leu Val Leu Arg Arg Glu 
1               5                   10          


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

His Phe Ser Ser Trp Glu Thr Gln Gln Gly 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Trp Tyr Glu Lys Trp Gln Lys Ala Asn Trp 
1               5                   10  


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Val Ser Gly Ser Ser Pro Asp Ser 
1               5               


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Ser Ser Lys Lys Ser Gly Ser Tyr Ser Gly Ser Lys Gly Ser Arg Arg 
1               5                   10                  15      


Ile Leu Gly Gly Gly Gly Met His Gly Lys Thr Gln Ala Thr Ser Gly 
            20                  25                  30          


Thr Ile Gln Ser 
        35      


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Met Ser Pro His Pro His Pro Arg His His His Thr Gly Gly Gly Gly 
1               5                   10                  15      


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
            20                  25                  30  


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Arg Gly Arg Arg Arg Arg Leu Ser Cys Arg Leu Leu Gly Gly Gly Gly 
1               5                   10                  15      


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
            20                  25                  30  


<210>  12
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Asp Ser Ala Arg Gly Phe Lys Lys Pro Gly Lys Arg Gly Gly Gly Gly 
1               5                   10                  15      


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
            20                  25                  30  


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

His Pro Pro Met Asn Ala Ser His Pro His Met His Gly Gly Gly Gly 
1               5                   10                  15      


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

His Lys Asp His His Ala Asn Gln His Val His Met Gly Gly Gly Gly 
1               5                   10                  15      


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
            20                  25                  30  


<210>  15
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Pro Thr Thr Gly Ser Cys Ala Val Thr Tyr Thr Ala Asn Gly Trp Ser 
1               5                   10                  15      


Gly Gly Phe Thr Ala Ala Val Thr Leu Thr Asn Thr Gly Thr Thr Ala 
            20                  25                  30          


Leu Ser Gly Trp Thr Leu Gly Phe Ala Phe Pro Ser Gly Gln Thr Leu 
        35                  40                  45              


Thr Gln Gly Trp Ser Ala Arg Trp Ala Gln Ser Gly Ser Ser Val Thr 
    50                  55                  60                  


Ala Thr Asn Glu Ala Trp Asn Ala Val Leu Ala Pro Gly Ala Ser Val 
65                  70                  75                  80  


Glu Ile Gly Phe Ser Gly Thr His Thr Gly Thr Asn Thr Ala Pro Ala 
                85                  90                  95      


Thr Phe Thr Val Gly Gly Ala Thr Cys Thr Thr Arg 
            100                 105             


<210>  16
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Ser Gly Pro Ala Gly Cys Gln Val Leu Trp Gly Val Asn Gln Trp Asn 
1               5                   10                  15      


Thr Gly Phe Thr Ala Asn Val Thr Val Lys Asn Thr Ser Ser Ala Pro 
            20                  25                  30          


Val Asp Gly Trp Thr Leu Thr Phe Ser Phe Pro Ser Gly Gln Gln Val 
        35                  40                  45              


Thr Gln Ala Trp Ser Ser Thr Val Thr Gln Ser Gly Ser Ala Val Thr 
    50                  55                  60                  


Val Arg Asn Ala Pro Trp Asn Gly Ser Ile Pro Ala Gly Gly Thr Ala 
65                  70                  75                  80  


Gln Phe Gly Phe Asn Gly Ser His Thr Gly Thr Asn Ala Ala Pro Thr 
                85                  90                  95      


Ala Phe Ser Leu Asn Gly Thr Pro Cys Thr Val Gly 
            100                 105             


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17

Arg Ala Phe Ile Ala Ser Arg Arg Ile Arg Arg Pro 
1               5                   10          


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Arg Ile Ile Ile Arg Arg Ile Arg Arg 
1               5                   


<210>  19
<211>  196
<212>  PRT
<213>  Unknown

<220>
<223>  Streptococcus sp.

<400>  19

Met Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr 
1               5                   10                  15      


Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln 
            20                  25                  30          


Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala 
        35                  40                  45              


Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala Ser 
    50                  55                  60                  


Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys 
65                  70                  75                  80  


Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala 
                85                  90                  95      


Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu 
            100                 105                 110         


Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro 
        115                 120                 125             


Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys 
    130                 135                 140                 


Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala 
145                 150                 155                 160 


Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp 
                165                 170                 175     


Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe 
            180                 185                 190         


Thr Val Thr Glu 
        195     


<210>  20
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Met Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr 
1               5                   10                  15      


Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln 
            20                  25                  30          


Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala 
        35                  40                  45              


Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala Ser 
    50                  55                  60                  


Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys 
65                  70                  75                  80  


Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala 
                85                  90                  95      


Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu 
            100                 105                 110         


Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro 
        115                 120                 125             


Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys 
    130                 135                 140                 


Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys Ala 
145                 150                 155                 160 


Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn Asp 
                165                 170                 175     


Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe 
            180                 185                 190         


Thr Val Thr Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        195                 200                 205             


Gly Gly Ser Ala Ser Gly Gly Gly Met His Gly Lys Thr Gln Ala Thr 
    210                 215                 220                 


Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly 
225                 230                 235                 240 


Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile 
                245                 250                 255     


Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
            260                 265                 270         


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His 
        275                 280                 285             


Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys 
    290                 295                 300                 


Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
305                 310                 


<210>  21
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly 
            180 


<210>  22
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


<210>  23
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile 
            180                 185                 190         


Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser 
        195                 200                 205             


Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His 
    210                 215                 220                 


Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys 
225                 230                 235                 240 


Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln 
                245                 250                 255     


Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr 
            260                 265                 270         


Ser Gly Thr Ile Gln Ser 
        275             


<210>  24
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Val Ser Gly Ser Ser Pro Asp Ser 
            180                 185             


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Arg Gly Arg Arg Arg Arg Leu Ser Cys Arg Leu Leu 
1               5                   10          


<210>  26
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Arg Gly Arg Arg Arg Arg Leu Ser Cys Arg Leu Leu 
            180                 185                 190         


<210>  27
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Pro Thr Thr Gly Ser Cys Ala Val Thr Tyr Thr Ala 
            180                 185                 190         


Asn Gly Trp Ser Gly Gly Phe Thr Ala Ala Val Thr Leu Thr Asn Thr 
        195                 200                 205             


Gly Thr Thr Ala Leu Ser Gly Trp Thr Leu Gly Phe Ala Phe Pro Ser 
    210                 215                 220                 


Gly Gln Thr Leu Thr Gln Gly Trp Ser Ala Arg Trp Ala Gln Ser Gly 
225                 230                 235                 240 


Ser Ser Val Thr Ala Thr Asn Glu Ala Trp Asn Ala Val Leu Ala Pro 
                245                 250                 255     


Gly Ala Ser Val Glu Ile Gly Phe Ser Gly Thr His Thr Gly Thr Asn 
            260                 265                 270         


Thr Ala Pro Ala Thr Phe Thr Val Gly Gly Ala Thr Cys Thr Thr Arg 
        275                 280                 285             


<210>  28
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Pro Ala Gly Cys Gln Val Leu Trp Gly Val 
            180                 185                 190         


Asn Gln Trp Asn Thr Gly Phe Thr Ala Asn Val Thr Val Lys Asn Thr 
        195                 200                 205             


Ser Ser Ala Pro Val Asp Gly Trp Thr Leu Thr Phe Ser Phe Pro Ser 
    210                 215                 220                 


Gly Gln Gln Val Thr Gln Ala Trp Ser Ser Thr Val Thr Gln Ser Gly 
225                 230                 235                 240 


Ser Ala Val Thr Val Arg Asn Ala Pro Trp Asn Gly Ser Ile Pro Ala 
                245                 250                 255     


Gly Gly Thr Ala Gln Phe Gly Phe Asn Gly Ser His Thr Gly Thr Asn 
            260                 265                 270         


Ala Ala Pro Thr Ala Phe Ser Leu Asn Gly Thr Pro Cys Thr Val Gly 
        275                 280                 285             


<210>  29
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Met His His His His His His Glu Asn Tyr Leu Phe Gln Gly Gln Val 
1               5                   10                  15      


Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu 
            20                  25                  30          


Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Pro Ser Tyr Trp Ile 
        35                  40                  45              


Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Met 
    50                  55                  60                  


Ile Tyr Pro Ala Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly 
65                  70                  75                  80  


His Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr Leu Gln 
                85                  90                  95      


Trp Ala Gly Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Leu Gly Ile Gly Gly Arg Tyr Met Ser Arg Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
    130                 135                 140                 


Thr Pro Thr Thr Pro Thr Pro Thr Pro Ser Thr Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ala Met Ser Trp Val 
            180                 185                 190         


Arg Gln Thr Pro Glu Arg Lys Leu Glu Trp Val Ala Thr Val Gly Thr 
        195                 200                 205             


Gly Gly Phe Tyr Thr Phe Tyr Pro Asp Asn Val Glu Gly Arg Phe Thr 
    210                 215                 220                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser 
225                 230                 235                 240 


Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Val Arg Arg Glu Glu 
                245                 250                 255     


Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala 
            260                 265                 270         


Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala 
        275                 280                 285             


Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
    290                 295                 300                 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly 
305                 310                 315                 320 


Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser 
                325                 330                 335     


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr 
            340                 345                 350         


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
        355                 360                 365             


Val Pro Arg Asp Cys Thr Ser Lys Pro Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Gly Gly Gly Asp Ile Val 
385                 390                 395                 400 


Leu Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly Thr Ser Ala 
                405                 410                 415     


Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile 
            420                 425                 430         


Thr Phe Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        435                 440                 445             


Leu Ile Ser Gln Met Ser Thr Leu Ala Ser Gly Val Pro Asp Arg Phe 
    450                 455                 460                 


Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val 
465                 470                 475                 480 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn Leu Glu Leu 
                485                 490                 495     


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
            500                 505                 510         


Ala Ala Pro Thr Val Ser 
        515             


<210>  30
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Arg Ala Phe Ile Ala Ser Arg Arg Ile Arg Arg Pro 
            180                 185                 190         


<210>  31
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Met Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala 
1               5                   10                  15      


Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val 
            20                  25                  30          


Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val 
        35                  40                  45              


Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala 
    50                  55                  60                  


Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp 
65                  70                  75                  80  


Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln 
                85                  90                  95      


Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr 
            100                 105                 110         


Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His 
        115                 120                 125             


Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala 
    130                 135                 140                 


Lys Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
                165                 170                 175     


Ser Gly Gly Gly Arg Ile Ile Ile Arg Arg Ile Arg Arg 
            180                 185                 


<210>  32
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Arg Lys Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Gly Thr Gly Gly Phe Tyr Thr Phe Tyr Pro Asp Asn Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Glu Glu Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Thr Ser Lys Pro 
    210                 215                 220         


<210>  33
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

Asp Ile Val Leu Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Phe Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Ser Gln Met Ser Thr Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120     


<210>  34
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Met His His His His His His Glu Asn Leu Tyr Phe Gln Gly Asp Pro 
1               5                   10                  15      


Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly Ile Thr 
            20                  25                  30          


Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr Ala Gly 
        35                  40                  45              


Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val Gly Asn Ala 
    50                  55                  60                  


Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro Ala Thr 
65                  70                  75                  80  


Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys Asn Asn 
                85                  90                  95      


Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr Val Gly 
            100                 105                 110         


Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser Gly Thr 
        115                 120                 125             


Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp Thr Phe 
    130                 135                 140                 


Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys Lys Ala 
145                 150                 155                 160 


Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Gly Gly 
            180                 185                 190         


Gly Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met 
        195                 200                 205             


His Gly Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly 
    210                 215                 220                 


Lys Thr Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr 
225                 230                 235                 240 


Gln Ala Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala 
                245                 250                 255     


Thr Ser Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser 
            260                 265                 270         


Gly Thr Ile Gln Ser Met His Gly Lys Thr Gln Ala Thr Ser Gly Thr 
        275                 280                 285             


Ile Gln Ser 
    290     


