                         SEQUENCE LISTING

<110>  NovaRock Biotherapeutics, Ltd.
 
<120>  NECTIN-4 ANTIBODIES AND USES THEREOF

<130>  122863-5003-WO

<150>  63/074,864
<151>  2020-09-04

<150>  63/166,622
<151>  2021-03-26

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VH

<400>  1

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Ile Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VL

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Trp Cys Gln His Phe Trp Gly Asn Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 2_VH

<400>  3

Gln Val Gln Leu Lys Gln Ser Gly Pro Asn Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ala His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ile Gly Tyr Asp Gly Tyr Ala Met Asp Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_ mAb 2_VH

<400>  4

Asp Phe Gln Val Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VH

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Ile Ala Asp Lys Ala Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala His Tyr Tyr Gly Ser Ser Tyr Phe Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VL

<400>  6

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Thr 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VH

<400>  7

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Asn Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ile Thr Thr Ala Thr Gly Trp Tyr Leu Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VL

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ala Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VH

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Asn Gly Gly Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Leu Gly Gly Ser Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VL

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Thr Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110     


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VH

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Tyr Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VL

<400>  12

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 7_VH

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Ala Gly Ile Lys Ser Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 7_VL

<400>  14

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp 
            20                  25                  30          


Val Ser Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Thr Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 8_VH

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ile Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 8_VL

<400>  16

Ile Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Glu Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Asp Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys His Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VH

<400>  17

Asn Tyr Gly Val Asn 
1               5   


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VH

<400>  18

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VH

<400>  19

Glu Gly Tyr Asp Gly Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VL

<400>  20

Arg Ala Ser Glu Asn Ile Phe Ser Ser Leu Ala 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VL

<400>  21

Gly Ala Thr Asn Leu Ala Asp 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 1_VL

<400>  22

Gln His Phe Trp Gly Asn Pro Trp Thr 
1               5                   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 2_VH

<400>  23

Thr Tyr Gly Ala His 
1               5   


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 2_VH

<400>  24

Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser 
1               5                   10                  15      


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 2_VH

<400>  25

Ile Gly Tyr Asp Gly Tyr Ala Met Asp Asn 
1               5                   10  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_ mAb 2_VH

<400>  26

Arg Thr Ser Glu Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_ mAb 2_VH

<400>  27

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_ mAb 2_VH

<400>  28

Gln His Phe Trp Ser Ser Pro Trp Thr 
1               5                   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VH

<400>  29

Asp Thr Tyr Met His 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VH

<400>  30

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VH

<400>  31

Tyr Tyr Gly Ser Ser Tyr Phe Ala Met Asp Cys 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VL

<400>  32

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VL

<400>  33

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 3_VL

<400>  34

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VH

<400>  35

Ser Ala Tyr Asn Trp His 
1               5       


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VH

<400>  36

Tyr Ile His Tyr Ser Gly Arg Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VH

<400>  37

Trp Ile Thr Thr Ala Thr Gly Trp Tyr Leu Asp Val 
1               5                   10          


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VL

<400>  38

Arg Ala Ser Glu Ser Val Ala Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VL

<400>  39

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 4_VL

<400>  40

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VH

<400>  41

Gly His Tyr Met His 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VH

<400>  42

Arg Val Asn Pro Asn Asn Gly Gly Ser Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VH

<400>  43

Asp Pro Leu Gly Gly Ser Tyr Gly Phe Ala Tyr 
1               5                   10      


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VL

<400>  44

Arg Ala Ser Gln Ser Val Thr Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VL

<400>  45

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 5_VL

<400>  46

Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VH

<400>  47

Thr Tyr Tyr Ile His 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VH

<400>  48

Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Thr Glu Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VH

<400>  49

Gly Leu Tyr Tyr Phe Asp Phe 
1               5           


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VL

<400>  50

Lys Ala Ser Gln Ser Val Asn Asn Asp Val Ala 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VL

<400>  51

Tyr Ala Ser Asn Arg Asp Thr 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 6_VL

<400>  52

Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 7_VH

<400>  53

Trp Ile Tyr Pro Gly Asn Ala Gly Ile Lys Ser Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 7_VH

<400>  54

Gly Val Tyr Phe Phe Asp Tyr 
1               5           


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 7_VL

<400>  55

Lys Ala Ser Gln Ser Val Asn Asn Asp Val Ser 
1               5                   10      


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 7_VL

<400>  56

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 8_VH

<400>  57

Ser Tyr Tyr Ile His 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 8_VH

<400>  58

Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Asn Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 8_VH

<400>  59

Gly Ile Tyr Tyr Phe Asp Tyr 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence_N4_mAb 8_VL

<400>  60

His Gln Asp Tyr Ser Ser Pro Phe Thr 
1               5                   


<210>  61
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  62
<211>  510
<212>  PRT
<213>  Macaca fascicularis

<400>  62

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Ala Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Val Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Thr Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  63
<211>  508
<212>  PRT
<213>  Rattus norvegicus

<400>  63

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ala Ser Phe Thr Gly Arg Tyr Ser Ala Gly Glu 
            20                  25                  30          


Leu Glu Thr Ser Asp Leu Val Thr Val Val Leu Gly Gln Asp Ala Lys 
        35                  40                  45              


Leu Pro Cys Phe Tyr Arg Gly Asp Pro Asp Glu Gln Val Gly Gln Val 
    50                  55                  60                  


Ala Trp Ala Arg Val Asp Pro Asn Glu Gly Thr Arg Glu Leu Ala Leu 
65                  70                  75                  80  


Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Asp Arg 
                85                  90                  95      


Val Glu Gln Pro Pro Pro Pro Arg Asp Pro Leu Asp Gly Ser Ile Leu 
            100                 105                 110         


Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg Val 
        115                 120                 125             


Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Met Arg Leu Arg Val 
    130                 135                 140                 


Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Pro Leu Glu Glu 
145                 150                 155                 160 


Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro 
                165                 170                 175     


Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Gln Ser Ser 
            180                 185                 190         


Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe His 
        195                 200                 205             


Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val 
    210                 215                 220                 


Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Thr Leu Gln 
225                 230                 235                 240 


Val Ala Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln Asn 
                245                 250                 255     


Leu Trp His Val Gly Arg Glu Gly Ala Thr Leu Lys Cys Leu Ser Glu 
            260                 265                 270         


Gly Gln Pro Pro Pro Lys Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu 
        275                 280                 285             


Pro Ser Gly Val Arg Val Lys Gly Asp Thr Leu Gly Phe Pro Pro Leu 
    290                 295                 300                 


Thr Thr Glu His Ser Gly Val Tyr Val Cys His Val Ser Asn Glu Leu 
305                 310                 315                 320 


Ser Ser Arg Ala Ser Gln Val Thr Val Glu Val Leu Asp Pro Glu Asp 
                325                 330                 335     


Pro Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val Val Gly 
            340                 345                 350         


Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val Val Leu 
        355                 360                 365             


Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr 
    370                 375                 380                 


Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His 
385                 390                 395                 400 


Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu 
                405                 410                 415     


Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser 
            420                 425                 430         


Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr 
        435                 440                 445             


Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly 
    450                 455                 460                 


Arg Thr Glu Glu Glu Asp Asp Gln Asp Glu Gly Ile Lys Gln Ala Met 
465                 470                 475                 480 


Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly 
                485                 490                 495     


Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505             


<210>  64
<211>  508
<212>  PRT
<213>  Mus musculus

<400>  64

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Arg Leu Leu Phe Leu Ala Ser Phe Thr Gly Gln Tyr Ser Ala Gly Glu 
            20                  25                  30          


Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala Lys 
        35                  40                  45              


Leu Pro Cys Phe Tyr Arg Gly Asp Pro Asp Glu Gln Val Gly Gln Val 
    50                  55                  60                  


Ala Trp Ala Arg Val Asp Pro Asn Glu Gly Ile Arg Glu Leu Ala Leu 
65                  70                  75                  80  


Leu His Ser Lys Tyr Gly Leu His Val Asn Pro Ala Tyr Glu Asp Arg 
                85                  90                  95      


Val Glu Gln Pro Pro Pro Pro Arg Asp Pro Leu Asp Gly Ser Val Leu 
            100                 105                 110         


Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg Val 
        115                 120                 125             


Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Met Arg Leu Arg Val 
    130                 135                 140                 


Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Pro Leu Glu Glu 
145                 150                 155                 160 


Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser Pro 
                165                 170                 175     


Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Gln Ser Ser 
            180                 185                 190         


Arg Ser Phe Thr His Pro Arg Ser Ala Ala Val Thr Ser Glu Phe His 
        195                 200                 205             


Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val Val 
    210                 215                 220                 


Ser His Pro Gly Leu Leu Gln Asp Arg Arg Ile Thr His Thr Leu Gln 
225                 230                 235                 240 


Val Ala Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln Asn 
                245                 250                 255     


Leu Trp Gln Val Gly Arg Glu Gly Ala Thr Leu Lys Cys Leu Ser Glu 
            260                 265                 270         


Gly Gln Pro Pro Pro Lys Tyr Asn Trp Thr Arg Leu Asp Gly Pro Leu 
        275                 280                 285             


Pro Ser Gly Val Arg Val Lys Gly Asp Thr Leu Gly Phe Pro Pro Leu 
    290                 295                 300                 


Thr Thr Glu His Ser Gly Val Tyr Val Cys His Val Ser Asn Glu Leu 
305                 310                 315                 320 


Ser Ser Arg Asp Ser Gln Val Thr Val Glu Val Leu Asp Pro Glu Asp 
                325                 330                 335     


Pro Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Ile Ile Val Gly 
            340                 345                 350         


Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val Val Leu 
        355                 360                 365             


Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln Lys Tyr 
    370                 375                 380                 


Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg Leu His 
385                 390                 395                 400 


Ser His His Ser Asp Pro Arg Ser Gln Pro Glu Glu Ser Val Gly Leu 
                405                 410                 415     


Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser Cys Ser 
            420                 425                 430         


Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu Thr Thr 
        435                 440                 445             


Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly Ser Gly 
    450                 455                 460                 


Arg Thr Glu Glu Asp Asp Asp Gln Asp Glu Gly Ile Lys Gln Ala Met 
465                 470                 475                 480 


Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro Thr Gly 
                485                 490                 495     


Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505             


<210>  65
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Arg Met Gly Leu Ala Gly Ala Ala Gly Arg Trp Trp Gly Leu 
1               5                   10                  15      


Ala Leu Gly Leu Thr Ala Phe Phe Leu Pro Gly Val His Ser Gln Val 
            20                  25                  30          


Val Gln Val Asn Asp Ser Met Tyr Gly Phe Ile Gly Thr Asp Val Val 
        35                  40                  45              


Leu His Cys Ser Phe Ala Asn Pro Leu Pro Ser Val Lys Ile Thr Gln 
    50                  55                  60                  


Val Thr Trp Gln Lys Ser Thr Asn Gly Ser Lys Gln Asn Val Ala Ile 
65                  70                  75                  80  


Tyr Asn Pro Ser Met Gly Val Ser Val Leu Ala Pro Tyr Arg Glu Arg 
                85                  90                  95      


Val Glu Phe Leu Arg Pro Ser Phe Thr Asp Gly Thr Ile Arg Leu Ser 
            100                 105                 110         


Arg Leu Glu Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Phe Ala Thr 
        115                 120                 125             


Phe Pro Thr Gly Asn Arg Glu Ser Gln Leu Asn Leu Thr Val Met Ala 
    130                 135                 140                 


Lys Pro Thr Asn Trp Ile Glu Gly Thr Gln Ala Val Leu Arg Ala Lys 
145                 150                 155                 160 


Lys Gly Gln Asp Asp Lys Val Leu Val Ala Thr Cys Thr Ser Ala Asn 
                165                 170                 175     


Gly Lys Pro Pro Ser Val Val Ser Trp Glu Thr Arg Leu Lys Gly Glu 
            180                 185                 190         


Ala Glu Tyr Gln Glu Ile Arg Asn Pro Asn Gly Thr Val Thr Val Ile 
        195                 200                 205             


Ser Arg Tyr Arg Leu Val Pro Ser Arg Glu Ala His Gln Gln Ser Leu 
    210                 215                 220                 


Ala Cys Ile Val Asn Tyr His Met Asp Arg Phe Lys Glu Ser Leu Thr 
225                 230                 235                 240 


Leu Asn Val Gln Tyr Glu Pro Glu Val Thr Ile Glu Gly Phe Asp Gly 
                245                 250                 255     


Asn Trp Tyr Leu Gln Arg Met Asp Val Lys Leu Thr Cys Lys Ala Asp 
            260                 265                 270         


Ala Asn Pro Pro Ala Thr Glu Tyr His Trp Thr Thr Leu Asn Gly Ser 
        275                 280                 285             


Leu Pro Lys Gly Val Glu Ala Gln Asn Arg Thr Leu Phe Phe Lys Gly 
    290                 295                 300                 


Pro Ile Asn Tyr Ser Leu Ala Gly Thr Tyr Ile Cys Glu Ala Thr Asn 
305                 310                 315                 320 


Pro Ile Gly Thr Arg Ser Gly Gln Val Glu Val Asn Ile Thr Glu Phe 
                325                 330                 335     


Pro Tyr Thr Pro Ser Pro Pro Glu His Gly Arg Arg Ala Gly Pro Val 
            340                 345                 350         


Pro Thr Ala Ile Ile Gly Gly Val Ala Gly Ser Ile Leu Leu Val Leu 
        355                 360                 365             


Ile Val Val Gly Gly Ile Val Val Ala Leu Arg Arg Arg Arg His Thr 
    370                 375                 380                 


Phe Lys Gly Asp Tyr Ser Thr Lys Lys His Val Tyr Gly Asn Gly Tyr 
385                 390                 395                 400 


Ser Lys Ala Gly Ile Pro Gln His His Pro Pro Met Ala Gln Asn Leu 
                405                 410                 415     


Gln Tyr Pro Asp Asp Ser Asp Asp Glu Lys Lys Ala Gly Pro Leu Gly 
            420                 425                 430         


Gly Ser Ser Tyr Glu Glu Glu Glu Glu Glu Glu Glu Gly Gly Gly Gly 
        435                 440                 445             


Gly Glu Arg Lys Val Gly Gly Pro His Pro Lys Tyr Asp Glu Asp Ala 
    450                 455                 460                 


Lys Arg Pro Tyr Phe Thr Val Asp Glu Ala Glu Ala Arg Gln Asp Gly 
465                 470                 475                 480 


Tyr Gly Asp Arg Thr Leu Gly Tyr Gln Tyr Asp Pro Glu Gln Leu Asp 
                485                 490                 495     


Leu Ala Glu Asn Met Val Ser Gln Asn Asp Gly Ser Phe Ile Ser Lys 
            500                 505                 510         


Lys Glu Trp Tyr Val 
        515         


