                         SEQUENCE LISTING

<110>  Jin,  Rongsheng
       Chen, Peng
 
<120>  A BROADLY NEUTRALIZING MOLECULE AGAINST CLOSTRIDIUM DIFFICILE 
       TOXIN B

<130>  UCI 20.24 PCT

<150>  63/073,831
<151>  2020-09-02

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  1

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  2
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Leu Pro Glu Pro Cys Val Pro Glu Pro Gly Leu Pro Pro Val Phe 
1               5                   10                  15      


Ala Asn Phe Thr Gln Leu Leu Thr Ile Ser Pro Leu Val Val Ala Glu 
            20                  25                  30          


Gly Gly Thr Ala Trp Leu Glu Trp Arg His Val Gln Pro Thr Leu Asp 
        35                  40                  45              


Leu Met Glu Ala Glu Leu Arg Lys Ser Gln Val Leu Phe Ser Val Thr 
    50                  55                  60                  


Arg Gly Ala Arg His Gly Glu Leu Glu Leu Asp Ile Pro Gly Ala Gln 
65                  70                  75                  80  


Ala Arg Lys Met Phe Thr Leu Leu Asp Val Val Asn Arg Lys Ala Arg 
                85                  90                  95      


Phe Ile His Asp Gly Ser Glu Asp Thr Ser Asp Gln Leu Val Leu Glu 
            100                 105                 110         


Val Ser Val Thr Ala Arg Val Pro Met Pro Ser Cys Leu Arg Arg Gly 
        115                 120                 125             


Gln Thr Tyr Leu Leu Pro Ile Gln Val Asn Pro Val Asn Asp 
    130                 135                 140         


<210>  3
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Ser Phe Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala 
1               5                   10                  15      


Leu Thr Asp Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu 
            20                  25                  30          


Ala Leu Leu Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln 
        35                  40                  45              


Leu Tyr Ser Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu 
    50                  55                  60                  


Leu Arg Leu Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro 
65                  70                  75                  80  


His Thr Val Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val 
                85                  90                  95      


Asp Gly Phe Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu 
            100                 105                 110         


Val Pro Tyr Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro 
        115                 120                 125             


Tyr Leu Arg Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala 
    130                 135                 140                 


Thr Leu Asn Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His 
145                 150                 155                 160 


Glu Gly Cys Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly 
                165                 170                 175     


Phe Ser Gly Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln 
            180                 185                 190         


Asp Glu Gly Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala 
        195                 200                 205             


Pro Leu Ala Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val 
    210                 215                 220                 


Asp Ile Phe Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly 
225                 230                 235                 240 


Thr Val Leu Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His 
                245                 250                 255     


Glu Val Ser Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp 
            260                 265                 270         


Gln Tyr Pro Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu 
        275                 280                 285             


Pro Arg Gly Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg 
    290                 295                 300                 


His Leu Gln Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala 
305                 310                 315                 320 


Ser Leu Leu Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg 
                325                 330                 335     


Gly Leu Arg Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg 
            340                 345                 350         


Leu Glu Glu Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala 
        355                 360                 365             


Phe Ser Thr Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu 
    370                 375                 380                 


Pro Cys Val Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr 
385                 390                 395                 400 


Gln Leu Leu Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala 
                405                 410                 415     


Trp Leu Glu Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala 
            420                 425                 430         


Glu Leu Arg Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg 
        435                 440                 445             


His Gly Glu Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met 
    450                 455                 460                 


Phe Thr Leu Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp 
465                 470                 475                 480 


Gly Ser Glu Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr 
                485                 490                 495     


Ala Arg Val Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu 
            500                 505                 510         


Leu Pro Ile Gln Val Asn Pro Val Asn Asp 
        515                 520         


<210>  4
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Tyr Asn Gly Glu Arg Gly Ile Ser Ile Pro Asp His Gly Tyr Cys 
1               5                   10                  15      


Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln Thr 
            20                  25                  30          


Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly Leu 
        35                  40                  45              


Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Ala Glu 
    50                  55                  60                  


Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val Leu 
65                  70                  75                  80  


Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg Gln 
                85                  90                  95      


Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Asp Thr 
            100                 105                 110         


Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly Glu Leu Cys Val 
        115                 120                 125             


Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro Ser Leu Leu Pro 
    130                 135                 140                 


Glu Phe Trp Thr Ser Asn Pro Gln His Gly Gly Gly Gly Tyr 
145                 150                 155             


<210>  5
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Phe His Gly Glu Lys Gly Ile Ser Ile Pro Asp His Gly Phe Cys 
1               5                   10                  15      


Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln Thr 
            20                  25                  30          


Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly Leu 
        35                  40                  45              


Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro Glu 
    50                  55                  60                  


Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val Leu 
65                  70                  75                  80  


Glu Gln Ala Ile Pro Pro Cys Arg Ser Ile Cys Glu Arg Ala Arg Gln 
                85                  90                  95      


Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu Arg 
            100                 105                 110         


Leu Arg Cys Glu His Phe Pro Arg His Gly Ala Glu Gln Ile Cys Val 
        115                 120                 125             


Gly Gln Asn His Ser Glu Asp Gly Ala Pro Ala Leu Leu Thr Thr Ala 
    130                 135                 140                 


Pro Pro Ser Gly Leu Gln Pro Gly Ala Gly Gly Thr Pro Gly Gly Pro 
145                 150                 155                 160 


Gly Gly Gly 
            


<210>  6
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Pro Tyr His Gly Glu Lys Gly Ile Ser Val Pro Asp His Gly Phe 
1               5                   10                  15      


Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
            20                  25                  30          


Thr Ile Leu Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
        35                  40                  45              


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
    50                  55                  60                  


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
65                  70                  75                  80  


Leu Asp Gln Ala Ile Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
                85                  90                  95      


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
            100                 105                 110         


Arg Leu Arg Cys Glu Asn Phe Pro Val His Gly Ala Gly Glu Ile Cys 
        115                 120                 125             


Val Gly Gln Asn Thr Ser Asp Gly Ser Gly Gly Ala Gly 
    130                 135                 140     


<210>  7
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  8
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized VHH 5D nanobody

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  11
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer TcdBcore

<400>  11
gggaattcca tatgtctgct tggtctcacc cacaattcg                              39


<210>  12
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer TcdBcore

<400>  12
ccgctcgagt ttgaaagcct tgccggtttc cgggc                                  35


<210>  13
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Full Length TcdB1

<400>  13
catgccatgg gctctgcttg gtctcaccca caattcg                                37


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Full length TcdB1

<400>  14
ccgctcgagt tagtgatgat gatgatgatg ttcag                                  35


<210>  15
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer CSPG4mini

<400>  15
cgcggatccg cttccttctt cggtgagaac cacc                                   34


<210>  16
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Revese Primer CSPG4mini

<400>  16
ttcttggacc ggttactgca cctccagggc caggttctcc                             40


<210>  17
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Repeat1-Fc

<400>  17
cgcggatccg agctgcctga gccatgcgtg cctg                                   34


<210>  18
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Repeat1-Fc

<400>  18
ctagtctaga gtcattgaca gggttgacct ggatg                                  35


<210>  19
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer CSPG4-ECD

<400>  19
ccggaattcg cttccttctt cggtgagaac cacc                                   34


<210>  20
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer CSPG4-ECD

<400>  20
ctagtctaga gctggatgcc atggggcctg gctcg                                  35


<210>  21
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer His-Repeat1

<400>  21
cgcggatccg agctgcctga gccatgcgtg cctg                                   34


<210>  22
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer His-Repeat1

<400>  22
ctagtctaga ctagtcattg acagggttga cctggatg                               38


<210>  23
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Bezlo LC

<400>  23
aaaaggcctg agattgtgct gacacagtcc cccg                                   34


<210>  24
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Bezlo LC

<400>  24
ctagtctaga ttagcattct cctctattga agctcttggt c                           41


<210>  25
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Bezlo HC

<400>  25
aaaaggcctg aggtgcagct cgtgcagagc ggcg                                   34


<210>  26
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Bezlo HC

<400>  26
ctagtctaga gcaggacttg ggctccaccc tcttatcg                               38


<210>  27
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer Belzo VH-CH1

<400>  27
aaaaggcctg aggtgcagct cgtgcagagc ggcg                                   34


<210>  28
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Bezlo VH-CH1

<400>  28
ctagtctaga ttagcaggac ttgggctcca ccctcttatc g                           41


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Alkene moiety

<400>  29

Ile Pro Ser Ile Ile Ser Asp Arg Pro Lys 
1               5                   10  


<210>  30
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  unsaturated thiol moiety

<400>  30

His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
1               5                   10                  


<210>  31
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Ile or Leu

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Asp, Gly, or His

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Val or Ile

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  Asn or Lys

<400>  31

Leu Glu Ile Ser Ser Arg Pro Tyr Tyr Thr Asn Xaa Tyr Xaa Xaa Leu 
1               5                   10                  15      


Tyr Phe Ile Met Xaa 
            20      


<210>  32
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  32

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Glu Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Asn Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Asn Glu Lys 
    1715                 1720                 1725             


Ile Asn  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ser  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Val Asn Val  Phe Lys Asp 
    1760                 1765                 1770             


Lys Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Pro Val Ser Glu Ile  Ile Leu Ser Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Leu Ile Gly  Tyr Asp Leu Gly Leu  Val Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Val Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Ile Asn  Gly Gly Ala Ala Ser  Ile Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ser Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Asp Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  His Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Tyr  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Val Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Asn  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  His Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Glu Asp Gly  Phe Lys Tyr Phe Ala  His His Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Glu Ile Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Leu Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asn  Pro Glu Thr Lys Lys  Ala Cys Lys Gly Ile  Asn Leu Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Lys Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn Asn Tyr Tyr Phe  Asn Glu Asn 
    2255                 2260                 2265             


Gly Glu  Met Gln Phe Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Gly Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  33
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  33

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val Lys 
705                 710                 715                 720 


Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Val Val Glu Gly Arg Ile Glu Glu Ala Lys Ser Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Leu Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Val Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Ile Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Ser  His Ile Ser 
    1115                 1120                 1125             


Leu Ala  Glu Ser Glu Gly Ala  Phe Thr Ser Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Thr Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Val Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Asn Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Asn Glu  Asn Asp Thr Trp Val  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Asn  Ile Leu Ser Lys Leu  Ser Ile Glu Asp Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asp  Asn His Glu Ile Asn  Phe Ser Gly Thr Leu  Asn Gly Gly 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Val Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Thr  Leu Met Ala Asn Ser  Asn Ser Val 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Leu Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Met  Asp Asp Lys Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Cys Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Ser Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asn Ser Lys 
    1490                 1495                 1500             


Pro Leu  Phe Gly Tyr Cys Ser  Asn Asp Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asp Val Ile  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Phe Thr Ile Gln  Asp Glu Asn 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Gly Val  Tyr Leu Asp Glu Asn  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Lys Lys Gly Ser Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Ile  Asn Ser Leu Gln Ser  Asn Thr Lys Leu Ile  Leu Asp Thr 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Lys Asp Asn Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Lys Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Ile Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Ile Tyr Glu Ala  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Thr Asn Tyr Ile  Ser Glu Lys 
    1715                 1720                 1725             


Ile Asn  Ile Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Ser Asp Phe Ile  Leu Met Ser Thr Asp  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Thr Asn Val  Phe Lys Gly 
    1760                 1765                 1770             


Asn Thr  Ile Ser Asp Lys Ile  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Ser Ile Asn Lys Val  Ile Ser Thr Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Val  Glu Gly Leu Leu Asn  Tyr Asp Leu Gly Leu  Ile Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Val Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Ile Lys  Asn Leu Ile Thr Gly  Phe Thr Thr Ile Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Asp Asn  Gly Gly Ala Ala Ser  Val Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Gly Lys Asn  Tyr Tyr Phe Ser Gln  Asn Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asp Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Thr  Ile Asp Glu Asn Val  Tyr Tyr Phe 
    1925                 1930                 1935             


Gly Asp  Asn Tyr Arg Ala Ala  Ile Glu Trp Gln Thr  Leu Asp Asp 
    1940                 1945                 1950             


Glu Val  Tyr Tyr Phe Ser Thr  Asp Thr Gly Arg Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Asp  Lys Phe Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Ile Met  Gln Lys Gly Phe Val  Asn Ile Asn Asp Lys  Thr Phe Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Ser Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  Tyr Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Ala Asp Gly  Phe Lys Tyr Phe Ala  His His Asp 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Ala Leu Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Ile Ser Ile 
    2090                 2095                 2100             


Ile Asn  Asp Gly Lys Tyr Tyr  Phe Asn Asp Ser Gly  Ile Met Gln 
    2105                 2110                 2115             


Ile Gly  Phe Val Thr Ile Asn  Asn Glu Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Val Glu Ser Gly  Met Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Glu Asn Gly  Leu Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asp  Pro Glu Thr Lys Lys  Ala Tyr Lys Gly Ile  Asn Val Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Asn Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Thr Phe Glu Asp  Asn His Tyr Tyr Phe  Asn Glu Asp 
    2255                 2260                 2265             


Gly Ile  Met Gln Tyr Gly Tyr  Leu Asn Ile Glu Asp  Lys Thr Phe 
    2270                 2275                 2280             


Tyr Phe  Ser Glu Asp Gly Ile  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Gln Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  34
<211>  1440
<212>  PRT
<213>  Clostridium difficile

<400>  34

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asn Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Ile 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Lys Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Val Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Thr Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Val Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asn Ser Glu Val Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Ser 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Asn Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg Glu 
        915                 920                 925             


Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Val Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Ile Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Ala  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Ile  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asn Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ser  Pro Thr Ile Thr Tyr  Ile Lys Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Glu Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp His Tyr Lys Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Asn  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu His Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe His Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Asp Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Asp Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  His His Glu Ile Asn  Phe Ser Gly Asp Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Ile Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  
    1430                 1435                 1440 


<210>  35
<211>  1280
<212>  PRT
<213>  Clostridium difficile

<400>  35

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Ile Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro 
    290                 295                 300                 


Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala 
305                 310                 315                 320 


Ile Met Lys His Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe 
                325                 330                 335     


Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala 
            340                 345                 350         


Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu 
        355                 360                 365             


Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile 
    370                 375                 380                 


Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu 
385                 390                 395                 400 


Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly 
                405                 410                 415     


Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe 
            420                 425                 430         


Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile 
        435                 440                 445             


Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn 
    450                 455                 460                 


Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys 
465                 470                 475                 480 


Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser 
                485                 490                 495     


Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala 
            500                 505                 510         


Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Arg Ala 
        515                 520                 525             


Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu 
    530                 535                 540                 


Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys 
545                 550                 555                 560 


Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg 
                565                 570                 575     


Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr 
            580                 585                 590         


Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu 
        595                 600                 605             


Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro 
    610                 615                 620                 


Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg 
625                 630                 635                 640 


Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys 
                645                 650                 655     


Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu 
            660                 665                 670         


Ser Ser Glu Ile Glu Thr Ala Ile Gly Leu Ala Lys Glu Asp Ile Ser 
        675                 680                 685             


Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr 
    690                 695                 700                 


Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val 
705                 710                 715                 720 


Lys Asp Lys Val Ser Glu Leu Met Pro Ser Met Ser Gln Asp Ser Ile 
                725                 730                 735     


Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
            740                 745                 750         


Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
        755                 760                 765             


Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys 
    770                 775                 780                 


Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr 
785                 790                 795                 800 


Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu 
                805                 810                 815     


Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn 
            820                 825                 830         


Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu 
        835                 840                 845             


Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu 
    850                 855                 860                 


Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu 
865                 870                 875                 880 


Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly 
                885                 890                 895     


Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val 
            900                 905                 910         


Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu 
        915                 920                 925             


Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys 
    930                 935                 940                 


Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu 
945                 950                 955                 960 


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys 
                965                 970                 975     


Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala 
            980                 985                 990         


Gln Leu Phe Ser Thr Gly Leu Asn  Thr Ile Thr Asp Ala  Ala Lys Val 
        995                 1000                 1005             


Val Glu  Leu Val Ser Thr Ala  Leu Asp Glu Thr Ile  Asp Leu Leu 
    1010                 1015                 1020             


Pro Thr  Leu Ser Glu Gly Leu  Pro Ile Ile Ala Thr  Ile Ile Asp 
    1025                 1030                 1035             


Gly Val  Ser Leu Gly Ala Ala  Ile Lys Glu Leu Ser  Glu Thr Ser 
    1040                 1045                 1050             


Asp Pro  Leu Leu Arg Gln Glu  Ile Glu Ala Lys Ile  Gly Ile Met 
    1055                 1060                 1065             


Ala Val  Asn Leu Thr Thr Ala  Thr Thr Ala Ile Ile  Thr Ser Ser 
    1070                 1075                 1080             


Leu Gly  Ile Ala Ser Gly Phe  Ser Ile Leu Leu Val  Pro Leu Ala 
    1085                 1090                 1095             


Gly Ile  Ser Ala Gly Ile Pro  Ser Leu Val Asn Asn  Glu Leu Val 
    1100                 1105                 1110             


Leu Arg  Asp Lys Ala Thr Lys  Val Val Asp Tyr Phe  Lys His Val 
    1115                 1120                 1125             


Ser Leu  Val Glu Thr Glu Gly  Val Phe Thr Leu Leu  Asp Asp Lys 
    1130                 1135                 1140             


Val Met  Met Pro Gln Asp Asp  Leu Val Ile Ser Glu  Ile Asp Phe 
    1145                 1150                 1155             


Asn Asn  Asn Ser Ile Val Leu  Gly Lys Cys Glu Ile  Trp Arg Met 
    1160                 1165                 1170             


Glu Gly  Gly Ser Gly His Thr  Val Thr Asp Asp Ile  Asp His Phe 
    1175                 1180                 1185             


Phe Ser  Ala Pro Ser Ile Thr  Tyr Arg Glu Pro His  Leu Ser Ile 
    1190                 1195                 1200             


Tyr Asp  Val Leu Glu Val Gln  Lys Glu Glu Leu Asp  Leu Ser Lys 
    1205                 1210                 1215             


Asp Leu  Met Val Leu Pro Asn  Ala Pro Asn Arg Val  Phe Ala Trp 
    1220                 1225                 1230             


Glu Thr  Gly Trp Thr Pro Gly  Leu Arg Ser Leu Glu  Asn Asp Gly 
    1235                 1240                 1245             


Thr Lys  Leu Leu Asp Arg Ile  Arg Asp Asn Tyr Glu  Gly Glu Phe 
    1250                 1255                 1260             


Tyr Trp  Arg Tyr Phe Ala Phe  Ile Ala Asp Ala Leu  Ile Thr Thr 
    1265                 1270                 1275             


Leu Lys  
    1280 


<210>  36
<211>  1280
<212>  PRT
<213>  Clostridium difficile

<400>  36

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Asp Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Pro Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Asp Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Val Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Ile  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp His Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  
    1280 


<210>  37
<211>  2367
<212>  PRT
<213>  Clostridium difficile

<400>  37

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro 
    290                 295                 300                 


Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala 
305                 310                 315                 320 


Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe 
                325                 330                 335     


Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala 
            340                 345                 350         


Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu 
        355                 360                 365             


Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile 
    370                 375                 380                 


Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu 
385                 390                 395                 400 


Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly 
                405                 410                 415     


Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe 
            420                 425                 430         


Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile 
        435                 440                 445             


Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn 
    450                 455                 460                 


Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys 
465                 470                 475                 480 


Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser 
                485                 490                 495     


Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala 
            500                 505                 510         


Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Arg Ala 
        515                 520                 525             


Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu 
    530                 535                 540                 


Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Ile Asp Lys 
545                 550                 555                 560 


Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg 
                565                 570                 575     


Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr 
            580                 585                 590         


Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu 
        595                 600                 605             


Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro 
    610                 615                 620                 


Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg 
625                 630                 635                 640 


Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys 
                645                 650                 655     


Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu 
            660                 665                 670         


Ser Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser 
        675                 680                 685             


Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr 
    690                 695                 700                 


Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val 
705                 710                 715                 720 


Lys Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile 
                725                 730                 735     


Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
            740                 745                 750         


Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
        755                 760                 765             


Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys 
    770                 775                 780                 


Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr 
785                 790                 795                 800 


Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu 
                805                 810                 815     


Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn 
            820                 825                 830         


Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu 
        835                 840                 845             


Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu 
    850                 855                 860                 


Ser Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu 
865                 870                 875                 880 


Glu Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly 
                885                 890                 895     


Phe Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val 
            900                 905                 910         


Glu Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu 
        915                 920                 925             


Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys 
    930                 935                 940                 


Leu Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu 
945                 950                 955                 960 


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys 
                965                 970                 975     


Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala 
            980                 985                 990         


Gln Leu Phe Ser Thr Gly Leu Asn  Thr Ile Thr Asp Ala  Ala Lys Val 
        995                 1000                 1005             


Val Glu  Leu Val Ser Thr Ala  Leu Asp Glu Thr Ile  Asp Leu Leu 
    1010                 1015                 1020             


Pro Thr  Leu Ser Glu Gly Leu  Pro Val Ile Ala Thr  Ile Ile Asp 
    1025                 1030                 1035             


Gly Val  Ser Leu Gly Ala Ala  Ile Lys Glu Leu Ser  Glu Thr Ser 
    1040                 1045                 1050             


Asp Pro  Leu Leu Arg Gln Glu  Ile Glu Ala Lys Ile  Gly Ile Met 
    1055                 1060                 1065             


Ala Val  Asn Leu Thr Ala Ala  Thr Thr Ala Ile Ile  Thr Ser Ser 
    1070                 1075                 1080             


Leu Gly  Ile Ala Ser Gly Phe  Ser Ile Leu Leu Val  Pro Leu Ala 
    1085                 1090                 1095             


Gly Ile  Ser Ala Gly Ile Pro  Ser Leu Val Asn Asn  Glu Leu Ile 
    1100                 1105                 1110             


Leu Arg  Asp Lys Ala Thr Lys  Val Val Asp Tyr Phe  Ser His Ile 
    1115                 1120                 1125             


Ser Leu  Ala Glu Ser Glu Gly  Ala Phe Thr Ser Leu  Asp Asp Lys 
    1130                 1135                 1140             


Ile Met  Met Pro Gln Asp Asp  Leu Val Ile Ser Glu  Ile Asp Phe 
    1145                 1150                 1155             


Asn Asn  Asn Ser Ile Thr Leu  Gly Lys Cys Glu Ile  Trp Arg Met 
    1160                 1165                 1170             


Glu Gly  Gly Ser Gly His Thr  Val Thr Asp Asp Ile  Asp His Phe 
    1175                 1180                 1185             


Phe Ser  Ser Pro Ser Ile Thr  Tyr Arg Glu Pro His  Leu Ser Ile 
    1190                 1195                 1200             


Tyr Asp  Val Leu Glu Val Lys  Lys Glu Glu Leu Asp  Leu Ser Lys 
    1205                 1210                 1215             


Asp Leu  Met Val Leu Pro Asn  Ala Pro Asn Arg Val  Phe Gly Trp 
    1220                 1225                 1230             


Glu Thr  Gly Trp Thr Pro Gly  Leu Arg Gly Leu Glu  Asn Asp Gly 
    1235                 1240                 1245             


Thr Lys  Leu Leu Asp Arg Ile  Arg Asp Gln Tyr Glu  Gly Gln Phe 
    1250                 1255                 1260             


Tyr Trp  Arg Phe Phe Ala Phe  Ile Ala Asp Ala Leu  Ile Thr Thr 
    1265                 1270                 1275             


Leu Lys  Pro Arg Tyr Glu Asp  Thr Asn Val Arg Ile  Ser Leu Asp 
    1280                 1285                 1290             


Ser Asn  Thr Arg Ser Phe Ile  Val Pro Val Ile Thr  Thr Glu Tyr 
    1295                 1300                 1305             


Ile Arg  Glu Lys Leu Ser Tyr  Ser Phe Tyr Gly Ser  Gly Gly Thr 
    1310                 1315                 1320             


Tyr Ala  Leu Ser Leu Ser Gln  Tyr Asn Met Asn Ile  Asn Ile Glu 
    1325                 1330                 1335             


Leu Asn  Glu Asn Asp Thr Trp  Val Ile Asp Val Asp  Asn Val Val 
    1340                 1345                 1350             


Arg Ser  Val Thr Ile Glu Ser  Asp Lys Ile Lys Lys  Gly Asp Leu 
    1355                 1360                 1365             


Ile Glu  Asn Ile Leu Ser Lys  Leu Ser Ile Glu Asp  Asn Lys Ile 
    1370                 1375                 1380             


Ile Leu  Asp Asn His Glu Ile  Asn Phe Ser Gly Thr  Leu Asn Gly 
    1385                 1390                 1395             


Gly Asn  Gly Phe Val Ser Leu  Thr Phe Ser Ile Leu  Glu Gly Ile 
    1400                 1405                 1410             


Asn Ala  Val Ile Glu Val Asp  Leu Leu Ser Lys Ser  Tyr Lys Val 
    1415                 1420                 1425             


Leu Ile  Ser Gly Glu Leu Lys  Thr Leu Met Ala Asn  Ser Asn Ser 
    1430                 1435                 1440             


Val Gln  Gln Lys Ile Asp Tyr  Ile Gly Leu Asn Ser  Glu Leu Gln 
    1445                 1450                 1455             


Lys Asn  Ile Pro Tyr Ser Phe  Met Asp Asp Lys Gly  Lys Glu Asn 
    1460                 1465                 1470             


Gly Phe  Ile Asn Cys Ser Thr  Lys Glu Gly Leu Phe  Val Ser Glu 
    1475                 1480                 1485             


Leu Ser  Asp Val Val Leu Ile  Ile Lys Val Tyr Met  Asp Asn Ser 
    1490                 1495                 1500             


Lys Pro  Pro Phe Gly Tyr Tyr  Ser Asn Asp Leu Lys  Asp Val Lys 
    1505                 1510                 1515             


Ala Ile  Thr Lys Asp Asp Val  Ile Ile Leu Thr Gly  Tyr Tyr Leu 
    1520                 1525                 1530             


Lys Asp  Asp Ile Lys Ile Ser  Leu Ser Phe Thr Ile  Gln Asp Lys 
    1535                 1540                 1545             


Asn Thr  Ile Lys Leu Asn Gly  Val Tyr Leu Asp Glu  Asn Gly Val 
    1550                 1555                 1560             


Ala Glu  Ile Leu Lys Phe Met  Asn Lys Lys Gly Ser  Thr Asn Thr 
    1565                 1570                 1575             


Ser Asp  Ser Leu Met Ser Phe  Leu Glu Ser Met Asn  Ile Lys Ser 
    1580                 1585                 1590             


Ile Phe  Ile Lys Ser Leu Lys  Ser Asn Ala Lys Leu  Ile Leu Asp 
    1595                 1600                 1605             


Thr Asn  Phe Ile Ile Ser Gly  Thr Thr Ser Ile Gly  Gln Phe Glu 
    1610                 1615                 1620             


Phe Ile  Cys Asp Lys Asp Asn  Asn Ile Gln Pro Tyr  Phe Ile Lys 
    1625                 1630                 1635             


Phe Asn  Thr Leu Glu Thr Lys  Tyr Thr Leu Tyr Val  Gly Asn Arg 
    1640                 1645                 1650             


Gln Asn  Met Ile Val Glu Pro  Asn Tyr Asp Leu Asp  Asp Ser Gly 
    1655                 1660                 1665             


Asp Ile  Ser Ser Thr Val Ile  Asn Phe Ser Gln Lys  Tyr Leu Tyr 
    1670                 1675                 1680             


Gly Ile  Asp Ser Cys Val Asn  Lys Val Ile Ile Ser  Pro Asn Ile 
    1685                 1690                 1695             


Tyr Thr  Asp Glu Ile Asn Ile  Thr Pro Ile Tyr Glu  Ala Asn Asn 
    1700                 1705                 1710             


Thr Tyr  Pro Glu Val Ile Val  Leu Asp Thr Asn Tyr  Ile Ser Glu 
    1715                 1720                 1725             


Lys Ile  Asn Ile Asn Ile Asn  Asp Leu Ser Ile Arg  Tyr Val Trp 
    1730                 1735                 1740             


Ser Asn  Asp Gly Ser Asp Phe  Ile Leu Met Ser Thr  Asp Glu Glu 
    1745                 1750                 1755             


Asn Lys  Val Ser Gln Val Lys  Ile Arg Phe Thr Asn  Val Phe Lys 
    1760                 1765                 1770             


Gly Asn  Thr Ile Ser Asp Lys  Ile Ser Phe Asn Phe  Ser Asp Lys 
    1775                 1780                 1785             


Gln Asp  Val Ser Ile Asn Lys  Ile Ile Ser Thr Phe  Thr Pro Ser 
    1790                 1795                 1800             


Tyr Tyr  Val Glu Gly Leu Leu  Asn Tyr His Leu Gly  Leu Ile Ser 
    1805                 1810                 1815             


Leu Tyr  Asn Glu Lys Phe Tyr  Ile Asn Asn Phe Gly  Met Met Val 
    1820                 1825                 1830             


Ser Gly  Leu Val Tyr Ile Asn  Asp Ser Leu Tyr Tyr  Phe Lys Pro 
    1835                 1840                 1845             


Pro Ile  Lys Asn Leu Ile Thr  Gly Phe Thr Thr Ile  Gly Asp Asp 
    1850                 1855                 1860             


Lys Tyr  Tyr Phe Asn Pro Asp  Asn Gly Gly Ala Ala  Ser Val Gly 
    1865                 1870                 1875             


Glu Thr  Ile Ile Asp Gly Lys  Asn Tyr Tyr Phe Ser  Pro Asn Gly 
    1880                 1885                 1890             


Val Leu  Gln Thr Gly Val Phe  Ser Thr Glu Asp Gly  Phe Lys Tyr 
    1895                 1900                 1905             


Phe Ala  Pro Ala Asp Thr Leu  Asp Glu Asn Leu Glu  Gly Glu Ala 
    1910                 1915                 1920             


Ile Asp  Phe Thr Gly Lys Leu  Ile Ile Asp Glu Asn  Val Tyr Tyr 
    1925                 1930                 1935             


Phe Gly  Asp Asn Tyr Arg Ala  Ala Ile Glu Trp Gln  Thr Leu Asp 
    1940                 1945                 1950             


Asp Glu  Val Tyr Tyr Phe Ser  Thr Asp Thr Gly Arg  Ala Phe Lys 
    1955                 1960                 1965             


Gly Leu  Asn Gln Ile Gly Asp  Asp Lys Phe Tyr Phe  Asn Ser Asp 
    1970                 1975                 1980             


Gly Ile  Met Gln Lys Gly Phe  Val Asn Ile Asn Asp  Lys Thr Phe 
    1985                 1990                 1995             


Tyr Phe  Asp Asp Ser Gly Val  Met Lys Ser Gly Tyr  Thr Glu Ile 
    2000                 2005                 2010             


Asp Gly  Lys His Phe Tyr Phe  Ala Glu Asn Gly Glu  Met Gln Ile 
    2015                 2020                 2025             


Gly Val  Phe Asn Thr Ala Asp  Gly Phe Lys Tyr Phe  Ala His His 
    2030                 2035                 2040             


Asp Glu  Asp Leu Gly Asn Glu  Glu Gly Glu Ala Leu  Ser Tyr Ser 
    2045                 2050                 2055             


Gly Ile  Leu Asn Phe Asn Asn  Lys Ile Tyr Tyr Phe  Asp Asp Ser 
    2060                 2065                 2070             


Phe Thr  Ala Val Val Gly Trp  Lys Asp Ser Glu Asp  Gly Ser Lys 
    2075                 2080                 2085             


Tyr Tyr  Phe Asp Glu Asp Thr  Ala Glu Ala Tyr Ile  Gly Ile Ser 
    2090                 2095                 2100             


Thr Ile  Asn Asp Gly Lys Tyr  Tyr Phe Asn Asp Ser  Gly Ile Met 
    2105                 2110                 2115             


Gln Ile  Gly Phe Val Thr Ile  Asn Asn Glu Val Phe  Tyr Phe Ser 
    2120                 2125                 2130             


Asp Ser  Gly Ile Val Glu Ser  Gly Met Gln Asn Ile  Asp Asp Asn 
    2135                 2140                 2145             


Tyr Phe  Tyr Ile Asp Glu Asn  Gly Leu Val Gln Ile  Gly Val Phe 
    2150                 2155                 2160             


Asp Thr  Ser Asp Gly Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val 
    2165                 2170                 2175             


Asn Asp  Asn Ile Tyr Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val 
    2180                 2185                 2190             


Arg Val  Gly Glu Asp Val Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile 
    2195                 2200                 2205             


Glu Thr  Gly Trp Ile Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr 
    2210                 2215                 2220             


Tyr Phe  Asp Pro Glu Thr Lys  Lys Ala Tyr Lys Gly  Ile Asn Val 
    2225                 2230                 2235             


Ile Asp  Asp Ile Lys Tyr Tyr  Phe Asp Glu Asn Gly  Ile Met Arg 
    2240                 2245                 2250             


Thr Gly  Leu Ile Thr Phe Glu  Asp Asn His Tyr Tyr  Phe Asn Glu 
    2255                 2260                 2265             


Asp Gly  Ile Met Gln Tyr Gly  Tyr Ile Asn Ile Glu  Asp Lys Met 
    2270                 2275                 2280             


Phe Tyr  Phe Asn Glu Asp Gly  Val Met Gln Ile Gly  Val Phe Asn 
    2285                 2290                 2295             


Thr Ala  Asp Gly Phe Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp 
    2300                 2305                 2310             


Glu Asn  Phe Glu Gly Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp 
    2315                 2320                 2325             


Leu Asp  Glu Lys Arg Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala 
    2330                 2335                 2340             


Ile Gly  Ser Val Ile Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro 
    2345                 2350                 2355             


Asp Thr  Ala Glu Leu Val Ile  Ser Glu 
    2360                 2365         


<210>  38
<211>  2367
<212>  PRT
<213>  Clostridium difficile

<400>  38

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Ile Leu Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Ile Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Ile Glu Ser Ala Ser Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Thr Gly Glu Val Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Gly Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asp Ile Asn Lys Pro 
    290                 295                 300                 


Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Gln Leu Glu Ala 
305                 310                 315                 320 


Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe 
                325                 330                 335     


Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala 
            340                 345                 350         


Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu 
        355                 360                 365             


Val Ser Pro Leu Glu Val Lys Val Ala Phe Ala Lys Gly Ser Ile Ile 
    370                 375                 380                 


Asn Gln Ala Leu Ile Ser Ala Lys Asp Ser Tyr Cys Ser Asp Leu Leu 
385                 390                 395                 400 


Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly 
                405                 410                 415     


Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Asn Phe 
            420                 425                 430         


Gly Glu Ser Leu Gly Ala Ile Ala Asn Glu Glu Asn Ile Ser Phe Ile 
        435                 440                 445             


Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn 
    450                 455                 460                 


Thr Thr Ile Thr Leu Ser Gly Pro Thr Ile Tyr Ala Gly Ala Tyr Lys 
465                 470                 475                 480 


Asp Leu Leu Thr Phe Lys Glu Met Ser Ile Asp Thr Ser Ile Leu Ser 
                485                 490                 495     


Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Val Asn Ile Ser Gln Ala 
            500                 505                 510         


Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Arg Ala 
        515                 520                 525             


Lys Ile Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu 
    530                 535                 540                 


Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys 
545                 550                 555                 560 


Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg 
                565                 570                 575     


Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr 
            580                 585                 590         


Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu 
        595                 600                 605             


Phe Gln Lys Asn Ile Glu Asp Ser Glu Val Ala Tyr Tyr Tyr Asn Pro 
    610                 615                 620                 


Thr Asp Ser Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg 
625                 630                 635                 640 


Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Leu Ile Gly His Gly Lys 
                645                 650                 655     


Ala Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu 
            660                 665                 670         


Ser Ser Glu Ile Glu Thr Ile Ile Asp Leu Ala Lys Ala Asp Ile Ser 
        675                 680                 685             


Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr 
    690                 695                 700                 


Ser Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Arg Val 
705                 710                 715                 720 


Lys Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile 
                725                 730                 735     


Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
            740                 745                 750         


Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
        755                 760                 765             


Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys 
    770                 775                 780                 


Glu Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr 
785                 790                 795                 800 


Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu 
                805                 810                 815     


Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn 
            820                 825                 830         


Ile Glu Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu 
        835                 840                 845             


Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu 
    850                 855                 860                 


Ser Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu 
865                 870                 875                 880 


Glu Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Asp Glu Gly 
                885                 890                 895     


Phe Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val 
            900                 905                 910         


Glu Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu 
        915                 920                 925             


Glu Ile Ser Lys Leu Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys 
    930                 935                 940                 


Leu Val Lys Lys Val Thr Leu Asp Ala Thr His Glu Val Asn Thr Leu 
945                 950                 955                 960 


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Asn Ser Ser Lys 
                965                 970                 975     


Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala 
            980                 985                 990         


Gln Leu Phe Ser Thr Gly Leu Asn  Thr Ile Thr Asp Ala  Ala Lys Val 
        995                 1000                 1005             


Val Glu  Leu Val Ser Thr Ala  Leu Asp Glu Thr Ile  Asp Leu Leu 
    1010                 1015                 1020             


Pro Thr  Leu Ser Glu Gly Leu  Pro Val Ile Ala Thr  Ile Ile Asp 
    1025                 1030                 1035             


Gly Val  Ser Leu Gly Ala Ser  Ile Lys Glu Leu Ser  Glu Thr Ser 
    1040                 1045                 1050             


Asp Pro  Leu Leu Arg Gln Glu  Ile Glu Ala Lys Ile  Gly Ile Met 
    1055                 1060                 1065             


Ala Val  Asn Leu Thr Ala Ala  Thr Thr Ala Ile Ile  Thr Ser Ser 
    1070                 1075                 1080             


Leu Gly  Ile Ala Ser Gly Phe  Ser Ile Leu Leu Val  Pro Leu Ala 
    1085                 1090                 1095             


Gly Ile  Ser Ala Gly Ile Pro  Ser Leu Val Asn Asn  Glu Leu Ile 
    1100                 1105                 1110             


Leu Arg  Ala Glu Ala Lys Asn  Val Val Asp Tyr Phe  Gly His Ile 
    1115                 1120                 1125             


Ser Leu  Ala Glu Ser Glu Gly  Ala Phe Thr Leu Leu  Asp Asp Lys 
    1130                 1135                 1140             


Ile Met  Met Pro Gln Asp Asp  Leu Val Ile Ser Glu  Ile Asp Phe 
    1145                 1150                 1155             


Asn Asn  Asn Ser Ile Thr Leu  Gly Lys Cys Glu Ile  Trp Arg Met 
    1160                 1165                 1170             


Glu Gly  Gly Ser Gly His Thr  Val Thr Asp Asp Ile  Asp His Phe 
    1175                 1180                 1185             


Phe Ser  Ala Pro Ser Thr Thr  Tyr Arg Glu Pro Tyr  Leu Ser Ile 
    1190                 1195                 1200             


Tyr Asp  Val Leu Asp Val Lys  Lys Glu Glu Leu Asp  Leu Ser Lys 
    1205                 1210                 1215             


Asp Leu  Met Val Leu Pro Asn  Ala Pro Asp Arg Ile  Phe Gly Trp 
    1220                 1225                 1230             


Glu Arg  Gly Trp Thr Pro Gly  Leu Arg Ser Leu Glu  Asn Asp Gly 
    1235                 1240                 1245             


Thr Lys  Leu Leu Asp Arg Ile  Arg Asp His Tyr Glu  Gly Gln Phe 
    1250                 1255                 1260             


Tyr Trp  Arg Phe Phe Ala Phe  Ile Ala Asp Ser Val  Ile Thr Lys 
    1265                 1270                 1275             


Leu Lys  Pro Arg Tyr Glu Asp  Thr Asn Ile Arg Ile  Ser Leu Asp 
    1280                 1285                 1290             


Ser Asn  Thr Arg Ser Phe Ile  Val Pro Val Ile Thr  Thr Glu Tyr 
    1295                 1300                 1305             


Ile Arg  Glu Lys Leu Ser Tyr  Ser Phe Tyr Gly Ser  Gly Gly Thr 
    1310                 1315                 1320             


Tyr Ala  Leu Ser Leu Ser Gln  Tyr Asn Met Asn Ile  Asn Ile Glu 
    1325                 1330                 1335             


Leu Asn  Glu Asn Asp Thr Trp  Val Ile Asp Val Asp  Asn Val Val 
    1340                 1345                 1350             


Arg Asp  Val Thr Ile Glu Ser  Asp Lys Ile Lys Lys  Gly Asp Leu 
    1355                 1360                 1365             


Ile Glu  Asn Ile Leu Ser Lys  Leu Ser Ile Glu Asp  Asn Lys Ile 
    1370                 1375                 1380             


Ile Leu  Asp Asn His Glu Ile  Asn Phe Ser Gly Thr  Leu Asn Gly 
    1385                 1390                 1395             


Gly Asn  Gly Phe Val Ser Leu  Thr Phe Ser Ile Leu  Glu Gly Ile 
    1400                 1405                 1410             


Asn Ala  Val Ile Glu Val Asp  Leu Leu Ser Lys Ser  Tyr Lys Val 
    1415                 1420                 1425             


Leu Ile  Ser Gly Glu Leu Lys  Thr Leu Met Ala Asn  Ser Asn Ser 
    1430                 1435                 1440             


Val Gln  Gln Lys Ile Asp Tyr  Ile Gly Leu Asn Ser  Glu Leu Gln 
    1445                 1450                 1455             


Lys Asn  Ile Pro Tyr Ser Phe  Met Asp Asp Glu Gly  Lys Glu Asn 
    1460                 1465                 1470             


Gly Phe  Ile Asn Cys Phe Thr  Lys Glu Gly Leu Phe  Val Ser Glu 
    1475                 1480                 1485             


Leu Ser  Asp Val Val Leu Ile  Ile Lys Val Tyr Met  Asp Asn Ser 
    1490                 1495                 1500             


Lys Pro  Pro Phe Gly Tyr Tyr  Ser Asn Asp Leu Lys  Asp Val Lys 
    1505                 1510                 1515             


Val Ile  Thr Lys Asp Asp Val  Ile Ile Leu Thr Gly  Tyr Tyr Leu 
    1520                 1525                 1530             


Lys Asp  Asp Ile Lys Ile Ser  Leu Ser Phe Thr Ile  Gln Asp Lys 
    1535                 1540                 1545             


Asn Thr  Ile Lys Leu Asn Gly  Val Tyr Leu Asp Glu  Asn Gly Val 
    1550                 1555                 1560             


Ala Glu  Ile Leu Lys Phe Met  Asn Lys Lys Gly Ser  Thr Asn Thr 
    1565                 1570                 1575             


Ser Asp  Ser Leu Met Ser Phe  Leu Glu Ser Met Asn  Ile Lys Ser 
    1580                 1585                 1590             


Ile Phe  Ile Lys Ser Leu Lys  Ser Asn Ala Lys Leu  Ile Leu Asp 
    1595                 1600                 1605             


Thr Asn  Phe Ile Ile Ser Gly  Thr Thr Ser Ile Gly  Gln Phe Glu 
    1610                 1615                 1620             


Phe Ile  Cys Asp Lys Asp Asn  Asn Ile Gln Pro Tyr  Phe Ile Lys 
    1625                 1630                 1635             


Phe Asn  Thr Leu Glu Thr Lys  Tyr Thr Leu Tyr Val  Gly Asn Arg 
    1640                 1645                 1650             


Gln Asn  Met Ile Val Glu Pro  Asn Tyr Asn Leu Asp  Asp Ser Gly 
    1655                 1660                 1665             


Asp Ile  Ser Ser Thr Val Ile  Asn Phe Ser Gln Lys  Tyr Leu Tyr 
    1670                 1675                 1680             


Gly Ile  Asp Ser Cys Val Asn  Lys Val Ile Ile Ser  Pro Asn Ile 
    1685                 1690                 1695             


Tyr Thr  Asp Glu Ile Asn Ile  Thr Pro Val His Glu  Ala Asn Asn 
    1700                 1705                 1710             


Thr Tyr  Pro Glu Val Ile Val  Leu Asp Thr Asn Tyr  Ile Ser Glu 
    1715                 1720                 1725             


Lys Ile  Asn Ile Asn Ile Asn  Asp Leu Ser Ile Arg  Tyr Val Trp 
    1730                 1735                 1740             


Ser Asn  Asp Gly Ser Asp Phe  Ile Leu Met Ser Thr  Asp Glu Glu 
    1745                 1750                 1755             


Asn Lys  Val Ser Gln Val Lys  Ile Arg Phe Thr Asn  Val Phe Lys 
    1760                 1765                 1770             


Gly Asn  Thr Ile Ser Asp Lys  Ile Ser Phe Asn Phe  Ser Asp Lys 
    1775                 1780                 1785             


Gln Asp  Ile Ser Ile Asn Lys  Ile Ile Ser Thr Phe  Thr Pro Ser 
    1790                 1795                 1800             


Tyr Tyr  Val Glu Gly Leu Leu  Asn Tyr Asp Leu Gly  Leu Ile Ser 
    1805                 1810                 1815             


Leu Tyr  Asn Glu Lys Phe Tyr  Ile Asn Asn Leu Gly  Met Met Val 
    1820                 1825                 1830             


Ser Gly  Leu Val Tyr Ile Asn  Asp Ser Leu Tyr Tyr  Phe Lys Pro 
    1835                 1840                 1845             


Pro Ile  Lys Asn Leu Ile Thr  Gly Phe Thr Thr Ile  Gly Asp Asp 
    1850                 1855                 1860             


Lys Tyr  Tyr Phe Asn Pro Asp  Asn Gly Gly Ala Ala  Ser Val Gly 
    1865                 1870                 1875             


Glu Thr  Ile Ile Asp Gly Lys  Asn Tyr Tyr Phe Ser  Gln Asn Gly 
    1880                 1885                 1890             


Val Leu  Gln Thr Gly Val Phe  Ser Thr Glu Asp Gly  Phe Lys Tyr 
    1895                 1900                 1905             


Phe Ala  Pro Ala Asp Thr Leu  Asp Glu Asn Leu Glu  Gly Glu Ala 
    1910                 1915                 1920             


Ile Asp  Phe Thr Gly Lys Leu  Ile Ile Asp Glu Asn  Val Tyr Tyr 
    1925                 1930                 1935             


Phe Gly  Asp Asn Tyr Arg Ala  Ala Ile Glu Trp Gln  Thr Leu Asp 
    1940                 1945                 1950             


Asp Glu  Val Tyr Tyr Phe Ser  Thr Asp Thr Gly Arg  Ala Phe Lys 
    1955                 1960                 1965             


Gly Leu  Asn Gln Ile Gly Asp  Asp Lys Phe Tyr Phe  Asn Ser Asp 
    1970                 1975                 1980             


Gly Ile  Met Gln Lys Gly Phe  Val Asn Ile Asn Asp  Lys Thr Phe 
    1985                 1990                 1995             


Tyr Phe  Asp Asp Ser Gly Val  Met Lys Ser Gly Tyr  Thr Glu Ile 
    2000                 2005                 2010             


Asp Gly  Lys Tyr Phe Tyr Phe  Ala Glu Asn Gly Glu  Met Gln Ile 
    2015                 2020                 2025             


Gly Val  Phe Asn Thr Ala Asp  Gly Phe Lys Tyr Phe  Ala His His 
    2030                 2035                 2040             


Asp Glu  Asp Leu Gly Asn Glu  Glu Gly Glu Ala Leu  Ser Tyr Ser 
    2045                 2050                 2055             


Gly Ile  Leu Asn Phe Asn Asn  Lys Ile Tyr Tyr Phe  Asp Asp Ser 
    2060                 2065                 2070             


Phe Thr  Ala Val Val Gly Trp  Lys Asp Leu Glu Asp  Gly Ser Lys 
    2075                 2080                 2085             


Tyr Tyr  Phe Asp Glu Asn Thr  Ala Glu Ala Ser Ile  Gly Ile Ser 
    2090                 2095                 2100             


Ile Ile  Asn Asp Gly Lys Tyr  Tyr Phe Asn Asp Ser  Gly Ile Met 
    2105                 2110                 2115             


Gln Ile  Gly Phe Val Thr Ile  Asn Asn Glu Val Phe  Tyr Phe Ser 
    2120                 2125                 2130             


Asp Ser  Gly Ile Val Glu Ser  Gly Met Gln Asn Ile  Asp Asp Asn 
    2135                 2140                 2145             


Tyr Phe  Tyr Ile Ser Glu Asn  Gly Leu Val Gln Ile  Gly Val Phe 
    2150                 2155                 2160             


Asp Thr  Ser Asp Gly Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val 
    2165                 2170                 2175             


Asn Asp  Asn Ile Tyr Gly Gln  Ala Val Glu Tyr Ser  Gly Leu Val 
    2180                 2185                 2190             


Arg Val  Asn Glu Asp Val Tyr  Ser Phe Gly Glu Ser  Tyr Thr Ile 
    2195                 2200                 2205             


Glu Thr  Gly Trp Ile Tyr Asp  Ser Glu Asn Glu Ser  Asp Lys Tyr 
    2210                 2215                 2220             


Tyr Phe  Asp Pro Glu Thr Lys  Lys Ala Tyr Lys Gly  Ile Asn Val 
    2225                 2230                 2235             


Ile Asp  Asp Ile Lys Tyr Tyr  Phe Asp Glu Asn Gly  Ile Met Arg 
    2240                 2245                 2250             


Thr Gly  Leu Ile Thr Phe Glu  Asp Asn His Tyr Tyr  Phe Asn Glu 
    2255                 2260                 2265             


Asp Gly  Glu Met Gln Tyr Gly  Tyr Leu Asn Ile Glu  Asp Lys Met 
    2270                 2275                 2280             


Phe Tyr  Phe Ser Glu Asp Gly  Ile Met Gln Ile Gly  Val Phe Asn 
    2285                 2290                 2295             


Thr Pro  Asp Gly Phe Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp 
    2300                 2305                 2310             


Glu Asn  Phe Glu Gly Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp 
    2315                 2320                 2325             


Leu Asp  Glu Lys Arg Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala 
    2330                 2335                 2340             


Thr Gly  Ser Val Ile Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro 
    2345                 2350                 2355             


Asp Thr  Ala Gln Leu Val Ile  Ser Glu 
    2360                 2365         


<210>  39
<211>  2367
<212>  PRT
<213>  Clostridium difficile

<400>  39

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Glu Phe Asn His Thr Ala Phe Phe Arg Lys Arg Met 
                165                 170                 175     


Gln Ile Ile Tyr Asp Lys Gln Gln Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Lys Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Thr Val Lys Ser 
        195                 200                 205             


Tyr Leu Ser Asp Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Ala Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asp Gly Glu Val Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Val Ala Ile Leu Lys Asn Ile Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile His Pro Asp Leu Phe Lys Asn Ile Asn Lys Pro 
    290                 295                 300                 


Asp Ser Val Lys Thr Ala Val Asp Trp Glu Glu Met Lys Leu Glu Ala 
305                 310                 315                 320 


Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Lys His Phe 
                325                 330                 335     


Asp Thr Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala 
            340                 345                 350         


Ser Lys Ser Asp Lys Ser Glu Ile Phe Leu Pro Leu Gly Asp Ile Glu 
        355                 360                 365             


Val Ser Pro Leu Glu Val Lys Ile Ala Phe Ala Lys Gly Ser Ile Ile 
    370                 375                 380                 


Asn Gln Ala Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asp Leu Leu 
385                 390                 395                 400 


Ile Lys Gln Ile Gln Asn Arg Tyr Lys Ile Leu Asn Asp Thr Leu Gly 
                405                 410                 415     


Pro Ile Ile Ser Gln Gly Asn Asp Phe Asn Thr Thr Met Asn Ser Phe 
            420                 425                 430         


Gly Glu Ser Leu Gly Ala Ile Ser Ser Glu Asp Asn Ile Ser Phe Ile 
        435                 440                 445             


Ala Lys Ile Gly Ser Tyr Leu Arg Val Gly Phe Tyr Pro Glu Ala Asn 
    450                 455                 460                 


Thr Thr Ile Thr Leu Ser Gly Pro Thr Val Tyr Ala Gly Ala Tyr Lys 
465                 470                 475                 480 


Asp Leu Leu Thr Phe Lys Glu Ile Ser Leu Asp Thr Ser Ile Leu Thr 
                485                 490                 495     


Ser Glu Leu Arg Asn Phe Glu Phe Pro Lys Asp Asn Ile Ser Gln Ala 
            500                 505                 510         


Thr Glu Gln Glu Lys Asn Ser Leu Trp Gln Phe Asn Glu Glu Arg Ala 
        515                 520                 525             


Lys Ile Gln Phe Glu Glu Tyr Lys Arg Ala Tyr Phe Glu Gly Ala Leu 
    530                 535                 540                 


Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Thr Asp Lys 
545                 550                 555                 560 


Glu Tyr Leu Leu Glu Lys Ile Ser Ser Ser Thr Lys Ser Ser Glu Arg 
                565                 570                 575     


Gly Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr 
            580                 585                 590         


Glu Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu 
        595                 600                 605             


Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro 
    610                 615                 620                 


Ala Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg 
625                 630                 635                 640 


Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys 
                645                 650                 655     


Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu 
            660                 665                 670         


Ser Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser 
        675                 680                 685             


Ser Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr 
    690                 695                 700                 


Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val 
705                 710                 715                 720 


Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile 
                725                 730                 735     


Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
            740                 745                 750         


Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
        755                 760                 765             


Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys 
    770                 775                 780                 


Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr 
785                 790                 795                 800 


Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu 
                805                 810                 815     


Glu Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn 
            820                 825                 830         


Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu 
        835                 840                 845             


Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu 
    850                 855                 860                 


Ser Ile Ser Asp Ser Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Asp 
865                 870                 875                 880 


Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Lys Thr Glu Asp Gly 
                885                 890                 895     


Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val 
            900                 905                 910         


Glu Thr Glu Lys Glu Ile Phe Ser Glu Tyr Ala Asn His Ile Glu Arg 
        915                 920                 925             


Glu Ile Ser Asn Ile Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys 
    930                 935                 940                 


Leu Val Lys Lys Val Asn Leu Asp Ala Ile His Glu Val Asn Thr Leu 
945                 950                 955                 960 


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Ser Ser Ser Lys 
                965                 970                 975     


Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala 
            980                 985                 990         


Gln Leu Phe Ser Thr Gly Leu Asn  Thr Ile Thr Asp Ala  Ala Lys Val 
        995                 1000                 1005             


Val Glu  Leu Val Ser Thr Ala  Leu Asp Glu Thr Ile  Asp Leu Leu 
    1010                 1015                 1020             


Pro Thr  Leu Ser Glu Gly Leu  Pro Val Ile Ala Thr  Ile Ile Asp 
    1025                 1030                 1035             


Gly Val  Ser Leu Gly Ala Ala  Ile Lys Glu Leu Ser  Glu Thr Ser 
    1040                 1045                 1050             


Asp Pro  Leu Leu Arg Gln Glu  Ile Glu Ala Lys Ile  Gly Ile Met 
    1055                 1060                 1065             


Ala Val  Asn Leu Thr Ala Ala  Thr Thr Ala Ile Ile  Thr Ser Ser 
    1070                 1075                 1080             


Leu Gly  Ile Ala Ser Gly Phe  Ser Ile Leu Leu Val  Pro Leu Ala 
    1085                 1090                 1095             


Gly Ile  Ser Ala Gly Ile Pro  Ser Leu Val Asn Asn  Glu Leu Val 
    1100                 1105                 1110             


Leu Arg  Asp Lys Ala Thr Lys  Val Val Asp Tyr Phe  Lys His Ile 
    1115                 1120                 1125             


Ser Leu  Val Glu Thr Glu Gly  Ala Phe Thr Leu Leu  Asp Asp Lys 
    1130                 1135                 1140             


Ile Met  Ile Pro Gln Asp Asp  Leu Val Ile Ser Glu  Ile Asp Phe 
    1145                 1150                 1155             


Asn Asn  Asn Ser Ile Val Leu  Gly Lys Cys Glu Ile  Trp Arg Met 
    1160                 1165                 1170             


Glu Gly  Gly Ser Gly His Thr  Val Thr Asn Asp Ile  Asp His Phe 
    1175                 1180                 1185             


Phe Ser  Ser Pro Thr Ile Thr  Tyr Ile Lys Pro His  Leu Ser Ile 
    1190                 1195                 1200             


Tyr Asp  Val Leu Glu Val Gln  Lys Glu Glu Leu Asp  Leu Ser Lys 
    1205                 1210                 1215             


Asp Leu  Met Val Leu Pro Asn  Ala Pro Asn Arg Val  Phe Ala Trp 
    1220                 1225                 1230             


Glu Thr  Gly Trp Thr Pro Gly  Leu Arg Ser Leu Glu  Asn Glu Gly 
    1235                 1240                 1245             


Thr Lys  Leu Leu Asp Arg Ile  Arg Asp His Tyr Lys  Gly Glu Phe 
    1250                 1255                 1260             


Tyr Trp  Arg Tyr Phe Ala Phe  Ile Ala Asp Ala Leu  Ile Thr Thr 
    1265                 1270                 1275             


Leu Lys  Pro Arg Tyr Glu Asp  Thr Asn Ile Arg Ile  Asn Leu Asp 
    1280                 1285                 1290             


Ser Asn  Asn Arg Ser Phe Ile  Val Pro Ile Ile Thr  Thr Glu His 
    1295                 1300                 1305             


Ile Arg  Glu Lys Leu Ser Tyr  Ser Phe His Gly Ser  Gly Gly Thr 
    1310                 1315                 1320             


Tyr Ala  Leu Ser Leu Ser Gln  Tyr Asn Met Gly Ile  Asn Ile Glu 
    1325                 1330                 1335             


Leu Ser  Glu Ser Asp Val Trp  Ile Ile Asp Val Asp  Asn Val Val 
    1340                 1345                 1350             


Arg Asp  Val Thr Ile Asp Ser  Asp Lys Ile Lys Lys  Gly Asp Leu 
    1355                 1360                 1365             


Ile Glu  Gly Ile Leu Ser Thr  Leu Ser Ile Glu Asp  Asn Lys Ile 
    1370                 1375                 1380             


Ile Leu  Asn His His Glu Ile  Asn Phe Ser Gly Asp  Val Asn Gly 
    1385                 1390                 1395             


Ser Asn  Gly Phe Ile Ser Leu  Thr Phe Ser Ile Leu  Glu Gly Ile 
    1400                 1405                 1410             


Asn Ala  Ile Ile Glu Val Asp  Leu Leu Ser Lys Ser  Tyr Lys Leu 
    1415                 1420                 1425             


Leu Ile  Ser Gly Glu Leu Lys  Ile Leu Met Leu Asn  Ser Asn His 
    1430                 1435                 1440             


Ile Gln  Gln Lys Ile Asp Tyr  Ile Gly Phe Asn Ser  Glu Leu Gln 
    1445                 1450                 1455             


Lys Asn  Ile Pro Tyr Ser Phe  Val Asp Ser Glu Gly  Lys Glu Asn 
    1460                 1465                 1470             


Gly Phe  Ile Asn Gly Ser Thr  Lys Glu Gly Leu Phe  Val Ser Glu 
    1475                 1480                 1485             


Leu Pro  Asp Val Val Leu Ile  Ser Lys Val Tyr Met  Asp Asp Ser 
    1490                 1495                 1500             


Lys Pro  Ser Phe Gly Tyr Tyr  Ser Asn Asn Leu Lys  Asp Val Lys 
    1505                 1510                 1515             


Val Ile  Thr Lys Asp Asn Val  Asn Ile Leu Thr Gly  Tyr Tyr Leu 
    1520                 1525                 1530             


Lys Asp  Asp Ile Lys Ile Ser  Leu Ser Phe Thr Leu  Gln Asp Glu 
    1535                 1540                 1545             


Lys Thr  Ile Lys Leu Asn Gly  Val His Leu Asp Glu  Ser Gly Val 
    1550                 1555                 1560             


Ala Glu  Ile Leu Lys Phe Met  Asn Lys Lys Gly Ser  Thr Asn Thr 
    1565                 1570                 1575             


Ser Asp  Ser Leu Met Ser Phe  Leu Glu Ser Val Asn  Ile Lys Ser 
    1580                 1585                 1590             


Ile Phe  Val Asn Phe Leu Gln  Ser Lys Ile Asn Phe  Ile Leu Asp 
    1595                 1600                 1605             


Ala Asn  Phe Ile Ile Ser Gly  Thr Thr Ser Ile Gly  Gln Phe Glu 
    1610                 1615                 1620             


Phe Ile  Cys Asp Glu Asn Asp  Asn Ile Gln Pro Tyr  Phe Ile Lys 
    1625                 1630                 1635             


Phe Asn  Thr Leu Glu Thr Thr  Tyr Thr Leu Tyr Val  Gly Asn Arg 
    1640                 1645                 1650             


Gln Asn  Met Ile Val Glu Pro  Asn Tyr Asp Leu Asp  Asp Ser Gly 
    1655                 1660                 1665             


Asp Ile  Ser Ser Thr Val Ile  Asn Phe Ser Gln Lys  Tyr Leu Tyr 
    1670                 1675                 1680             


Gly Ile  Asp Ser Cys Val Asn  Lys Val Val Ile Ser  Pro Asn Ile 
    1685                 1690                 1695             


Tyr Thr  Asp Glu Ile Asn Ile  Thr Pro Val Tyr Glu  Thr Asn Asn 
    1700                 1705                 1710             


Asn Tyr  Pro Glu Val Ile Val  Leu Asp Ala Asn Tyr  Ile Asn Glu 
    1715                 1720                 1725             


Lys Ile  Asn Val Asn Ile Asn  Asp Leu Ser Ile Arg  Tyr Val Trp 
    1730                 1735                 1740             


Ser Asn  Asp Gly Asn Asp Phe  Ile Leu Met Ser Thr  Ser Glu Glu 
    1745                 1750                 1755             


Asn Lys  Val Ser Gln Val Lys  Ile Arg Phe Val Asn  Val Phe Lys 
    1760                 1765                 1770             


Asp Lys  Thr Leu Ala Asn Lys  Leu Ser Phe Asn Phe  Ser Asp Lys 
    1775                 1780                 1785             


Gln Asp  Val Pro Val Ser Glu  Ile Ile Ser Ala Phe  Thr Pro Ser 
    1790                 1795                 1800             


Tyr Tyr  Glu Asp Gly Leu Ile  Gly Tyr Asp Leu Gly  Leu Val Ser 
    1805                 1810                 1815             


Leu Tyr  Asn Glu Lys Phe Tyr  Ile Asn Asn Phe Gly  Met Met Val 
    1820                 1825                 1830             


Ser Gly  Leu Ile Tyr Ile Asn  Asp Ser Leu Tyr Tyr  Phe Lys Pro 
    1835                 1840                 1845             


Pro Val  Asn Asn Leu Ile Thr  Gly Phe Val Thr Val  Gly Asp Asp 
    1850                 1855                 1860             


Lys Tyr  Tyr Phe Asn Pro Thr  Asn Gly Gly Ala Ala  Ser Ile Gly 
    1865                 1870                 1875             


Glu Thr  Ile Ile Asp Asp Lys  Asn Tyr Tyr Phe Asn  Gln Ser Gly 
    1880                 1885                 1890             


Ile Leu  Gln Thr Gly Val Phe  Ser Thr Glu Asp Gly  Leu Lys Tyr 
    1895                 1900                 1905             


Phe Ala  Pro Ala Asn Thr Leu  Asp Glu Asn Leu Glu  Gly Glu Ala 
    1910                 1915                 1920             


Ile Asp  Phe Thr Gly Lys Leu  Ile Ile Asp Glu Asn  Ile Tyr Tyr 
    1925                 1930                 1935             


Phe Glu  Asp Asn Tyr Arg Gly  Ala Val Glu Trp Lys  Glu Leu Asp 
    1940                 1945                 1950             


Gly Glu  Met Tyr Tyr Phe Ser  Pro Glu Thr Gly Lys  Ala Phe Lys 
    1955                 1960                 1965             


Gly Leu  Asn Gln Ile Gly Asp  Asp Lys Tyr Tyr Phe  Asn Ser Asp 
    1970                 1975                 1980             


Gly Ile  Met Lys Lys Gly Phe  Val Ser Ile Asn Asp  Lys Lys Tyr 
    1985                 1990                 1995             


Tyr Phe  Asp Asp Ser Gly Val  Met Lys Val Gly Tyr  Ile Glu Ile 
    2000                 2005                 2010             


Asp Gly  Lys Tyr Phe Tyr Phe  Ala Glu Asn Gly Glu  Met Gln Ile 
    2015                 2020                 2025             


Gly Val  Phe Asn Thr Ser Asp  Gly Phe Lys Tyr Phe  Ala His His 
    2030                 2035                 2040             


Asn Glu  Asp Leu Gly Asn Glu  Glu Gly Glu Ala Ile  Ser Tyr Ser 
    2045                 2050                 2055             


Gly Ile  Leu Asn Phe Asn Asn  Lys Ile Tyr Tyr Phe  Asp Tyr Ser 
    2060                 2065                 2070             


Phe Thr  Ala Val Val Gly Trp  Lys Asp Leu Glu Asp  Gly Ser Lys 
    2075                 2080                 2085             


Tyr Tyr  Phe Asp Glu Asp Thr  Ala Glu Ala Tyr Val  Gly Leu Ser 
    2090                 2095                 2100             


Leu Ile  Asn Asp Gly Gln Tyr  Tyr Phe Asn Asp Asp  Gly Ile Met 
    2105                 2110                 2115             


Gln Val  Gly Phe Val Thr Ile  Asn Asn Lys Val Phe  Tyr Phe Ser 
    2120                 2125                 2130             


Asp Ser  Gly Ile Ile Glu Ser  Gly Val Gln Asn Ile  Asp Asp Asn 
    2135                 2140                 2145             


Tyr Phe  Tyr Ile Asp Glu Lys  Gly Ile Val Gln Ile  Gly Val Phe 
    2150                 2155                 2160             


Asp Thr  Ser Asp Gly Tyr Lys  Tyr Phe Ala Pro Ala  Asn Thr Val 
    2165                 2170                 2175             


Asn Asp  Asn Ile Tyr Gly Gln  Ala Val Asp Tyr Ser  Gly Leu Val 
    2180                 2185                 2190             


Arg Val  Gly Glu Asp Ile Tyr  Tyr Phe Gly Glu Thr  Tyr Thr Ile 
    2195                 2200                 2205             


Glu Thr  Gly Trp Ile Tyr Asp  Met Glu Asn Glu Ser  Asp Lys Tyr 
    2210                 2215                 2220             


Tyr Phe  Asn Pro Glu Thr Lys  Lys Ala Cys Lys Gly  Ile Asn Leu 
    2225                 2230                 2235             


Ile Asp  Asp Ile Lys Tyr Tyr  Phe Asp Glu Asn Gly  Ile Met Arg 
    2240                 2245                 2250             


Thr Gly  Leu Ile Ser Phe Glu  Asn Asn Asp Tyr Tyr  Phe Asn Glu 
    2255                 2260                 2265             


Asn Gly  Glu Met His Phe Gly  Tyr Ile Asn Ile Glu  Asp Lys Met 
    2270                 2275                 2280             


Phe Tyr  Phe Gly Glu Asp Gly  Val Met Gln Ile Gly  Val Phe Asn 
    2285                 2290                 2295             


Thr Pro  Asp Gly Phe Lys Tyr  Phe Ala His Gln Asn  Thr Leu Asp 
    2300                 2305                 2310             


Glu Asn  Phe Glu Gly Glu Ser  Ile Asn Tyr Thr Gly  Trp Leu Asp 
    2315                 2320                 2325             


Leu Glu  Gly Lys Arg Tyr Tyr  Phe Thr Asp Glu Tyr  Ile Ala Ala 
    2330                 2335                 2340             


Thr Gly  Thr Val Thr Ile Asp  Gly Glu Glu Tyr Tyr  Phe Asp Pro 
    2345                 2350                 2355             


Asp Thr  Ala Glu Leu Val Val  Ser Glu 
    2360                 2365         


<210>  40
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  40

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ser Ala Thr Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Thr 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Ile 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ser Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Lys Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Ala Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 


Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Ser Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Glu 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Ala Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Leu Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Val Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Thr Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Val Ser 
    1115                 1120                 1125             


Leu Val  Glu Thr Glu Gly Val  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Val Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Ile  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Asn Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Ile Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Ile Asn  Phe Ser Gly Asp Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Ile  Leu Met Leu Asn Ser  Asn His Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ser Glu Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Gly Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Pro Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asn Asn Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asn Val Asn  Ile Leu Thr Ser Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Leu Thr Leu Gln  Asp Glu Lys 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Ser Val  His Leu Asp Glu Ser  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Arg Lys Gly Ser Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Val  Asn Phe Leu Gln Ser  Asn Ile Lys Phe Ile  Leu Asp Ala 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Asn Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Val Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Ala  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Thr Asn Tyr Ile  Ser Glu Lys 
    1715                 1720                 1725             


Ile Asn  Ile Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Ser Asp Phe Ile  Leu Met Ser Thr Asp  Glu Glu Asn 
    1745                 1750                 1755             


Lys Val  Ser Gln Val Lys Ile  Arg Phe Thr Asn Val  Phe Lys Gly 
    1760                 1765                 1770             


Asn Thr  Ile Ser Asp Lys Ile  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Ser Ile Asn Lys Ile  Ile Ser Thr Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Val  Glu Gly Leu Leu Asn  Tyr Asp Leu Gly Leu  Ile Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Val Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Ile Lys  Asn Leu Ile Thr Gly  Phe Thr Thr Ile Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Asp Asn  Gly Gly Ala Ala Ser  Val Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Gly Lys Asn  Tyr Tyr Phe Ser Gln  Asn Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asp Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Thr  Ile Asp Glu Asn Val  Tyr Tyr Phe 
    1925                 1930                 1935             


Gly Asp  Asn Tyr Arg Ala Ala  Ile Glu Trp Gln Thr  Leu Asp Asp 
    1940                 1945                 1950             


Glu Val  Tyr Tyr Phe Ser Thr  Asp Thr Gly Arg Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Asp  Lys Phe Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Ile Met  Gln Lys Gly Phe Val  Asn Ile Asn Asp Lys  Thr Phe Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Ser Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  Tyr Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Ala Asp Gly  Phe Lys Tyr Phe Ala  His His Asp 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Ala Leu Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asn Thr Ala  Glu Ala Ser Ile Gly  Ile Ser Ile 
    2090                 2095                 2100             


Ile Asn  Asp Gly Lys Tyr Tyr  Phe Asn Asp Ser Gly  Ile Met Gln 
    2105                 2110                 2115             


Ile Gly  Phe Val Thr Ile Asn  Asn Glu Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Val Glu Ser Gly  Met Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Ser Glu Asn Gly  Leu Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Asn  Glu Asp Val Tyr Ser  Phe Gly Glu Ser Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Ser  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asp  Pro Glu Thr Lys Lys  Ala Tyr Lys Gly Ile  Asn Val Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Asn Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Thr Phe Glu Asp  Asn His Tyr Tyr Phe  Asn Glu Asp 
    2255                 2260                 2265             


Gly Ile  Met Gln Tyr Gly Tyr  Leu Asn Ile Glu Asp  Lys Thr Phe 
    2270                 2275                 2280             


Tyr Phe  Ser Glu Asp Gly Ile  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Gly  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Glu Leu Val Ile Ser  Glu 
    2360                 2365     


<210>  41
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  41

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Thr Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Ser Ser Asn Val Val Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Lys Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Asp Ser Ala Thr Asn Glu Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asp Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Asp Phe Ile Ile Asp Asp Ile Val Lys Ser 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Val Lys Glu Asn Ser Gly Asn Asp Ile 
225                 230                 235                 240 


Arg Asp Phe Glu Glu Phe Lys Gly Gly Asn Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Ile Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Ile Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asp Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Tyr Ser Ile Asn Ile His Leu Leu Glu Ser 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Gln Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ala Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Ile Thr Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Ile Glu Lys Ile Ser Ser Ser Ala Lys Asn Ser Glu Arg Gly 
                565                 570                 575     


Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asn Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Thr Ile Ala Tyr Tyr Tyr Asn Pro Ala 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Arg Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Ser 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Asn Leu Asn Val Asp Ser Leu Ser 
            660                 665                 670         


Ser Glu Ile Glu Thr Ala Ile Asp Leu Ala Lys Thr Asp Ile Ser Pro 
        675                 680                 685             


Lys Ala Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Val Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Val Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Ser Lys Glu 
    770                 775                 780                 


Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Leu Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Ser Val Val Ser Asp Ile 
            820                 825                 830         


Asp Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Val Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ser Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ser Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Ile Leu 
    1100                 1105                 1110             


Arg Ala  Glu Ala Lys Asn Val  Val Asp Tyr Phe Ser  His Ile Ser 
    1115                 1120                 1125             


Leu Ala  Glu Ser Glu Gly Ala  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Ser Asn  Ser Ile Thr Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asn Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ala  Pro Ser Thr Thr Tyr  Arg Glu Pro Tyr Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Asp Val Lys Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asp Arg Ile Phe  Gly Trp Glu 
    1220                 1225                 1230             


Arg Gly  Trp Thr Pro Gly Leu  Arg Gly Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp His Tyr Glu Gly  Gln Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Phe Phe Ala Phe Ile  Ala Asp Ser Val Ile  Thr Lys Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Ser  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Val Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Asn Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Asn Glu  Ser Asp Thr Trp Val  Ile Asp Ile Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Asn  Ile Leu Ser Lys Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asp  Asn His Glu Ile Asn  Phe Ser Gly Thr Leu  Asn Gly Gly 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Val Leu 
    1415                 1420                 1425             


Ile Ser  Gly Glu Leu Lys Thr  Leu Met Glu Asn Ser  Asn Ser Val 
    1430                 1435                 1440             


Gln Gln  Lys Met Asp Tyr Ile  Gly Leu Asn Ser Glu  Val Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Thr  Asp Asp Lys Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Cys Ser Thr Lys  Glu Gly Leu Phe Val  Ser Glu Leu 
    1475                 1480                 1485             


Ser Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Ser Gly Tyr Tyr Ser  Tyr Asp Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asp Val Ile  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Phe Thr Ile Gln  Asp Glu Asn 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Gly Val  Tyr Leu Asp Glu Asn  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Lys Lys Gly Ser Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Ile  Asn Ser Leu Gln Ser  Asn Thr Lys Leu Ile  Leu Asp Thr 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Ala  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Lys Asp Asn Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Lys Tyr  Thr Leu Tyr Val Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asn Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Val Asn Lys  Val Ile Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Ala  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Thr Asn Tyr Ile  Ser Glu Lys 
    1715                 1720                 1725             


Ile Asn  Ile Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Ser Asp Phe Ile  Leu Met Ser Thr Asp  Glu Glu Asn 
    1745                 1750                 1755             


Lys Ile  Ser Gln Val Lys Ile  Arg Phe Thr Asn Val  Phe Lys Gly 
    1760                 1765                 1770             


Asn Thr  Ile Ala Asp Lys Ile  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Ser Ile Asn Lys Ile  Ile Ser Thr Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Val  Glu Gln Leu Leu Asn  Tyr Asp Leu Gly Leu  Ile Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Val Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Ile Lys  Asn Leu Ile Thr Gly  Phe Thr Thr Ile Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Asp Asn  Gly Gly Ala Ala Ser  Val Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Gly Lys Asn  Tyr Tyr Phe Ser Gln  Asn Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asp Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asn Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Gly Asp  Asn Tyr Arg Ala Ala  Glu Glu Trp Gln Thr  Leu Asp Asp 
    1940                 1945                 1950             


Glu Val  Tyr Tyr Phe Ser Thr  Asp Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Asp  Lys Phe Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Ile Met  Gln Lys Gly Phe Val  Asn Ile Asn Asp Lys  Thr Phe Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Ser Gly Tyr Leu  Glu Ile Tyr 
    2000                 2005                 2010             


Gly Lys  Tyr Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Thr Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asp 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Ala Leu Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Ile Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asn Thr Ala  Glu Ala Ser Ile Gly  Ile Ser Ile 
    2090                 2095                 2100             


Ile Asn  Asp Gly Lys Tyr Tyr  Phe Asn Asp Ser Gly  Ile Met Gln 
    2105                 2110                 2115             


Ile Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Val Glu Ser Gly  Met Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Ser Glu Asn Gly  Leu Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Lys 
    2180                 2185                 2190             


Val Asn  Glu Asp Val Tyr Ser  Phe Gly Glu Ser Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Ser  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asp  Pro Glu Thr Lys Lys  Ala Tyr Lys Gly Ile  Asn Thr Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Asn Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Thr Phe Glu Asp  Asn His Tyr Tyr Phe  Asn Glu Asp 
    2255                 2260                 2265             


Gly Val  Met Gln Tyr Gly Tyr  Leu Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Asn Glu Asp Gly Val  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Gly  Lys Lys Tyr Tyr Phe  Thr Glu Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Thr Ile Asp Asp  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Glu Leu Val Val Ser  Glu 
    2360                 2365     


<210>  42
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  42

Met Ser Leu Ile Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Lys 
1               5                   10                  15      


Phe Arg Val Gln Glu Asp Glu Tyr Ile Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Glu Thr Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  


Thr Glu Val Leu Glu Leu Lys Asn Ser Asn Val Ala Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Lys Ile Asn Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Asp Ser Ala Thr Asn Glu Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 


Leu Asp Asp Pro Arg Phe Asp Tyr Asn Lys Phe Tyr Arg Lys Arg Met 
                165                 170                 175     


Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Asp Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Asp Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Ser Lys Val Thr Glu Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Gly Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Val Ser Ala Leu Lys Glu Val Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Val Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Val Glu Ser 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Ser Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Tyr Ser Met Asn Ile His Leu Leu Glu Ser 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Gln Glu Tyr Lys Lys Asn Tyr Phe Glu Gly Ala Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Glu Asn Thr Val Leu Asp Lys Asp 
545                 550                 555                 560 


Tyr Ile Leu Glu Lys Ile Ser Ser Ser Thr Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Val His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Asn Pro Tyr Asp Ser Ile Leu Phe 
        595                 600                 605             


Gln Asn Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Ala 
    610                 615                 620                 


Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Asp Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Val Lys Leu Thr Phe Ile Gly His Gly Lys Ser 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Asn Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Ser Glu Ile Glu Thr Val Ile Asp Leu Ala Lys Thr Asp Ile Ser Pro 
        675                 680                 685             


Lys Ala Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Val Glu Asp Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Val Ser Glu Leu Leu Pro Ser Ile Asn Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Gln Glu 
    770                 775                 780                 


Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Val Gln Glu Ile Arg Asn Asn Ser Asn Ser Gly Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Ser Val Val Ser Asp Ile 
            820                 825                 830         


Asp Thr Gln Val Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Tyr Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asp Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Thr Lys Val Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Ala Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Gly Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Ile Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ala Ser Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ala Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Val Pro Ser  Leu Val Asn Asn Glu  Leu Val Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Ser  His Ile Ser 
    1115                 1120                 1125             


Leu Ala  Glu Ser Glu Gly Ala  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Met Met  Leu Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Thr Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Val Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ser  Pro Pro Ile Thr Tyr  Arg Glu Pro His Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Lys Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Gly Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Gly Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asp Tyr Tyr Glu Gly  Gln Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Phe Tyr Ala Phe Val  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Val Arg Ile Ser  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Ile Val  Pro Val Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Lys Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Asn Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Asn Glu  Asn Asp Thr Trp Val  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Asn  Ile Leu Ser Lys Leu  Ser Ile Glu Glu Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asp  Asn His Glu Ile Asn  Phe Ser Gly Thr Leu  Asn Gly Gly 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Val Leu 
    1415                 1420                 1425             


Val Ser  Gly Glu Leu Lys Thr  Leu Met Leu Asn Ser  Asn Ser Val 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Leu Asn Ser Glu  Val Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Thr  Asp Asp Lys Gly Lys  Glu Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Cys Ser Thr Lys  Glu Gly Leu Phe Ile  Ser Glu Leu 
    1475                 1480                 1485             


Ser Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asp Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly Tyr Tyr Ser  Asp Asp Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asp Val Ile  Leu Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Phe Thr Ile Gln  Asp Glu Asn 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Gly Val  Tyr Leu Asp Glu Asn  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Lys Phe Met Asn  Lys Lys Gly Ser Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Glu Ser Met Asn Ile  Lys Ser Ile 
    1580                 1585                 1590             


Phe Met  Asn Phe Val Gln Ser  Asn Val Lys Leu Ile  Leu Asp Thr 
    1595                 1600                 1605             


Asn Phe  Ile Ile Asn Gly Thr  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Lys Asp Asn Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Thr  Leu Glu Thr Lys Tyr  Thr Leu Tyr Val Gly  Asn Arg Glu 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asn Leu Asp Asp  Ser Gly Asp 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys Tyr  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Cys Ile Asn Lys  Val Ile Ile Ser Pro  Asn Ile Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val Tyr Glu Ala  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Ser Glu Lys 
    1715                 1720                 1725             


Ile Asn  Ile Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Val Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Ser Asp Phe Ile  Leu Met Ser Thr Asn  Glu Glu Asp 
    1745                 1750                 1755             


Lys Val  Ser Gln Ile Lys Ile  Arg Phe Thr Asn Val  Phe Lys Gly 
    1760                 1765                 1770             


Asn Thr  Met Ser Asp Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Ser Ile Ser Lys Ile  Ile Ser Thr Phe Thr  Pro Ser Tyr 
    1790                 1795                 1800             


Tyr Arg  Glu Asn Leu Leu Asn  Tyr Asp Leu Gly Met  Ile Ser Leu 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Met Val Ser 
    1820                 1825                 1830             


Gly Leu  Val Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Leu Lys  Asn Leu Ile Thr Gly  Phe Thr Thr Ile Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Asp Asn  Gly Gly Ala Ala Ser  Val Gly Glu 
    1865                 1870                 1875             


Thr Ile  Ile Asp Gly Lys Asn  Tyr Tyr Phe Ser Gln  Asn Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Thr  Ile Asp Glu Asn Val  Tyr Tyr Phe 
    1925                 1930                 1935             


Gly Asp  Asn Tyr Arg Ala Ala  Ile Glu Trp Gln Thr  Leu Asp Asp 
    1940                 1945                 1950             


Glu Met  Tyr Tyr Phe Ser Thr  Glu Thr Gly Arg Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Asp  Lys Phe Tyr Phe Asn  Ser Ser Gly 
    1970                 1975                 1980             


Ile Met  Gln Lys Gly Phe Val  Asn Ile Asn Asp Lys  Thr Phe Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Ser Gly Tyr Ile  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  Tyr Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Thr Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asp 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Ala Leu Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Lys  Asp Leu Glu Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asp Thr Ala  Glu Ala Tyr Ile Gly  Ile Ser Thr 
    2090                 2095                 2100             


Ile Asn  Asp Gly Gln Tyr Tyr  Phe Asn Asp Ser Gly  Ile Met Gln 
    2105                 2110                 2115             


Ile Gly  Phe Val Thr Ile Asn  Asp Lys Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Val Glu Ser Gly  Met Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Asp Asn Gly  Leu Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Ala Asn  Thr Val Asn 
    2165                 2170                 2175             


Asp Asn  Ile Tyr Gly Gln Ala  Val Glu Cys Ser Gly  Leu Val Arg 
    2180                 2185                 2190             


Val Gly  Glu Asp Val Tyr Cys  Phe Gly Glu Ser Tyr  Thr Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asp  Ser Glu Thr Lys Lys  Ala Tyr Lys Gly Ile  Asn Val Ile 
    2225                 2230                 2235             


Asp Asp  Ile Lys Tyr Tyr Phe  Asp Glu Asn Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn His Tyr Tyr Phe  Asn Ala Asp 
    2255                 2260                 2265             


Gly Glu  Met Gln Tyr Gly Tyr  Leu Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Ser Glu Asp Gly Phe  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Ser Thr  Leu Asp Glu 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Leu 
    2315                 2320                 2325             


Asp Asp  Lys Lys Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Ile Ile Asp Asp  Glu Glu Tyr Tyr Phe  Asp Pro Glu 
    2345                 2350                 2355             


Thr Ala  Glu Leu Val Val Ser  Glu 
    2360                 2365     


<210>  43
<211>  2366
<212>  PRT
<213>  Clostridium difficile

<400>  43

Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Lys 
1               5                   10                  15      


Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          


Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              


Leu Lys Asp Ile Asn Ser Leu Thr Asp Ala Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  


Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Thr 
65                  70                  75                  80  


Thr Glu Val Ile Glu Leu Lys Asn Ser Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      


Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Ser Asp Thr Ala Ile 
            100                 105                 110         


Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Thr Asn 
        115                 120                 125             


Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 


Ile Val Glu Ala Thr Thr Asn Asp Thr Leu Glu Ser Phe Ser Glu Asn 
145                 150                 155                 160 


Leu Asn Asp Pro Arg Phe Asp His Asn Asn Phe Tyr Arg Lys Arg Met 
                165                 170                 175     


Glu Met Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         


Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             


Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Ala Tyr 
    210                 215                 220                 


Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 


Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Lys Leu Tyr Glu 
                245                 250                 255     


Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         


Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Val Tyr Leu Asp Val Asp 
        275                 280                 285             


Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 


Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 


Met Lys Tyr Lys Glu Tyr Ile Pro Gly Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     


Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Ala Leu Ala Ser 
            340                 345                 350         


Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             


Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 


Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 


Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     


Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         


Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             


Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 


Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 


Leu Leu Met Phe Lys Glu Asp Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     


Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         


Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             


Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ala Leu Gly 
    530                 535                 540                 


Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Thr Val Val Asp Lys Glu 
545                 550                 555                 560 


Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     


Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         


Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Ile Leu Phe 
        595                 600                 605             


Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 


Asp Asp Glu Ile Gln Glu Ile Asp Lys Tyr Arg Ile Pro Ser Ile Ile 
625                 630                 635                 640 


Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     


Glu Phe Asn Thr Asp Ile Phe Ala Gly Leu Asp Val Asp Ser Leu Ser 
            660                 665                 670         


Thr Glu Ile Glu Thr Val Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             


Lys Ala Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 


Ile Asn Ile Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 


Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     


Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         


Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             


Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Ser Lys Glu 
    770                 775                 780                 


Asn Lys Ile Ile Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 


Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     


Glu Lys Val Met Leu Ala Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         


Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             


Ser Asp Ser Ile Asn Tyr Ile Lys Asn Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 


Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 


Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     


Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         


Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             


Ile Ser Lys Val Lys Asp Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 


Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 


Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     


Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         


Leu Phe Ser Thr Gly Leu Asn Thr  Ile Thr Asp Ala Ala  Lys Val Val 
        995                 1000                 1005             


Glu Leu  Val Ser Thr Ala Leu  Asp Glu Thr Ile Asp  Leu Leu Pro 
    1010                 1015                 1020             


Thr Leu  Ser Glu Gly Leu Pro  Val Ile Ala Thr Ile  Ile Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Gly Ser Ala Ile  Lys Glu Leu Ser Glu  Thr Ser Asp 
    1040                 1045                 1050             


Pro Leu  Leu Arg Gln Glu Ile  Glu Ala Lys Ile Gly  Ile Met Ala 
    1055                 1060                 1065             


Val Asn  Leu Thr Ala Ala Thr  Thr Ala Ile Ile Thr  Ser Ala Leu 
    1070                 1075                 1080             


Gly Ile  Ala Ser Gly Phe Ser  Ile Leu Leu Val Pro  Leu Ala Gly 
    1085                 1090                 1095             


Ile Ser  Ala Gly Ile Pro Ser  Leu Val Asn Asn Glu  Leu Ile Leu 
    1100                 1105                 1110             


Arg Asp  Lys Ala Thr Lys Val  Val Asp Tyr Phe Lys  His Ile Ser 
    1115                 1120                 1125             


Leu Ala  Glu Thr Glu Gly Ala  Phe Thr Leu Leu Asp  Asp Lys Ile 
    1130                 1135                 1140             


Ile Met  Pro Gln Asp Asp Leu  Val Ile Ser Glu Ile  Asp Phe Asn 
    1145                 1150                 1155             


Asn Asn  Ser Ile Thr Leu Gly  Lys Cys Glu Ile Trp  Arg Met Glu 
    1160                 1165                 1170             


Gly Gly  Ser Gly His Thr Val  Thr Asp Asp Ile Asp  His Phe Phe 
    1175                 1180                 1185             


Ser Ser  Pro Ser Ile Thr Tyr  Arg Glu Pro Tyr Leu  Ser Ile Tyr 
    1190                 1195                 1200             


Asp Val  Leu Glu Val Gln Lys  Glu Glu Leu Asp Leu  Ser Lys Asp 
    1205                 1210                 1215             


Leu Met  Val Leu Pro Asn Ala  Pro Asn Arg Val Phe  Ala Trp Glu 
    1220                 1225                 1230             


Thr Gly  Trp Thr Pro Gly Leu  Arg Ser Leu Glu Asn  Asp Gly Thr 
    1235                 1240                 1245             


Lys Leu  Leu Asp Arg Ile Arg  Asn His Tyr Glu Gly  Glu Phe Tyr 
    1250                 1255                 1260             


Trp Arg  Tyr Phe Ala Phe Ile  Ala Asp Ala Leu Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Arg Tyr Glu Asp Thr  Asn Ile Arg Ile Asn  Leu Asp Ser 
    1280                 1285                 1290             


Asn Thr  Arg Ser Phe Val Val  Pro Val Ile Thr Thr  Glu Tyr Ile 
    1295                 1300                 1305             


Arg Glu  Asn Leu Ser Tyr Ser  Phe Tyr Gly Ser Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ala Leu  Ser Leu Ser Gln Tyr  Asn Met Gly Ile Asn  Ile Glu Leu 
    1325                 1330                 1335             


Ser Glu  Ser Asp Val Trp Ile  Ile Asp Val Asp Asn  Val Val Arg 
    1340                 1345                 1350             


Asp Val  Thr Ile Glu Ser Asp  Lys Ile Lys Lys Gly  Asp Leu Ile 
    1355                 1360                 1365             


Glu Gly  Ile Leu Ser Thr Leu  Ser Ile Glu Asp Asn  Lys Ile Ile 
    1370                 1375                 1380             


Leu Asn  Ser His Glu Leu Asn  Phe Ser Gly Asp Val  Asn Gly Ser 
    1385                 1390                 1395             


Asn Gly  Phe Val Ser Leu Thr  Phe Ser Ile Leu Glu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Ile  Ile Glu Val Asp Leu  Leu Ser Lys Ser Tyr  Lys Leu Leu 
    1415                 1420                 1425             


Leu Ser  Gly Glu Leu Lys Thr  Leu Met Ser Asn Ser  Asn Tyr Ile 
    1430                 1435                 1440             


Gln Gln  Lys Ile Asp Tyr Ile  Gly Phe Asn Ser Glu  Leu Gln Lys 
    1445                 1450                 1455             


Asn Ile  Pro Tyr Ser Phe Val  Asp Ala Glu Gly Lys  Lys Asn Gly 
    1460                 1465                 1470             


Phe Ile  Asn Val Ser Thr Lys  Glu Gly Leu Phe Ala  Ser Glu Leu 
    1475                 1480                 1485             


Ser Asp  Val Val Leu Ile Ser  Lys Val Tyr Met Asp  Asn Ser Lys 
    1490                 1495                 1500             


Pro Ser  Phe Gly His Tyr Ser  Asp Ile Leu Lys Asp  Val Lys Val 
    1505                 1510                 1515             


Ile Thr  Lys Asp Asp Ile Asn  Ile Leu Thr Gly Tyr  Tyr Leu Lys 
    1520                 1525                 1530             


Asp Asp  Ile Lys Ile Ser Leu  Ser Phe Thr Leu Gln  Asp Glu His 
    1535                 1540                 1545             


Thr Ile  Lys Leu Asn Gly Val  His Leu Asp Glu Lys  Gly Val Ala 
    1550                 1555                 1560             


Glu Ile  Leu Thr Phe Met Asn  Lys Lys Val Gly Thr  Asn Thr Ser 
    1565                 1570                 1575             


Asp Ser  Leu Met Ser Phe Leu  Lys Ser Met Asn Ile  Asn Asn Val 
    1580                 1585                 1590             


Phe Ser  His Ser Leu Gln Asp  Lys Val Asn Leu Val  Leu Glu Thr 
    1595                 1600                 1605             


Asn Phe  Ile Ile Ser Gly Met  Thr Ser Ile Gly Gln  Phe Glu Phe 
    1610                 1615                 1620             


Ile Cys  Asp Glu Asn Asp Asn  Ile Gln Pro Tyr Phe  Ile Lys Phe 
    1625                 1630                 1635             


Asn Ala  Leu Asp Thr Lys Tyr  Thr Leu Tyr Leu Gly  Asn Arg Gln 
    1640                 1645                 1650             


Asn Met  Ile Val Glu Pro Asn  Tyr Asp Leu Asp Asp  Ser Gly Asn 
    1655                 1660                 1665             


Ile Ser  Ser Thr Val Ile Asn  Phe Ser Gln Lys His  Leu Tyr Gly 
    1670                 1675                 1680             


Ile Asp  Ser Phe Ile Asn Lys  Val Ile Ile Ser Pro  Asn Leu Tyr 
    1685                 1690                 1695             


Thr Asp  Glu Ile Asn Ile Thr  Pro Val His Glu Thr  Asn Asn Thr 
    1700                 1705                 1710             


Tyr Pro  Glu Val Ile Val Leu  Asp Ala Asn Tyr Ile  Ser Glu Lys 
    1715                 1720                 1725             


Ile Lys  Val Asn Ile Asn Asp  Leu Ser Ile Arg Tyr  Ile Trp Ser 
    1730                 1735                 1740             


Asn Asp  Gly Asn Asp Phe Ile  Leu Met Ser Thr Ile  Gly Glu Asp 
    1745                 1750                 1755             


Lys Ala  Ser Gln Val Lys Ile  Arg Phe Ala Asn Val  Phe Lys Gly 
    1760                 1765                 1770             


Asn Thr  Leu Ala Asn Lys Leu  Ser Phe Asn Phe Ser  Asp Lys Gln 
    1775                 1780                 1785             


Asp Val  Ser Leu Ser Glu Ile  Ile Ser Ala Phe Thr  Pro Ser Lys 
    1790                 1795                 1800             


Tyr Glu  Asp Gly Phe Ser Ser  Tyr Lys Leu Gly Leu  Ile Ser Phe 
    1805                 1810                 1815             


Tyr Asn  Glu Lys Phe Tyr Ile  Asn Asn Phe Gly Met  Lys Val Ser 
    1820                 1825                 1830             


Gly Leu  Ile Tyr Ile Asn Asp  Ser Leu Tyr Tyr Phe  Lys Pro Pro 
    1835                 1840                 1845             


Val Asn  Asn Leu Ile Thr Gly  Phe Thr Thr Val Gly  Asp Asp Lys 
    1850                 1855                 1860             


Tyr Tyr  Phe Asn Pro Thr Asn  Gly Gly Ala Ala Ser  Ile Gly Asp 
    1865                 1870                 1875             


Thr Ile  Ile Asp Asp Lys Asn  Tyr Tyr Phe Asn Gln  Ile Gly Val 
    1880                 1885                 1890             


Leu Gln  Thr Gly Val Phe Ser  Thr Glu Asp Gly Phe  Lys Tyr Phe 
    1895                 1900                 1905             


Ala Pro  Ala Asn Thr Leu Asp  Glu Asn Leu Glu Gly  Glu Ala Ile 
    1910                 1915                 1920             


Asp Phe  Thr Gly Lys Leu Ile  Ile Asp Glu Asn Ile  Tyr Tyr Phe 
    1925                 1930                 1935             


Glu Asp  Asn Tyr Arg Gly Ala  Val Glu Trp Lys Glu  Leu Asp Gly 
    1940                 1945                 1950             


Glu Met  Tyr Tyr Phe Ser Pro  Glu Thr Gly Lys Ala  Phe Lys Gly 
    1955                 1960                 1965             


Leu Asn  Gln Ile Gly Asp Asp  Lys Tyr Tyr Phe Asn  Ser Asp Gly 
    1970                 1975                 1980             


Ile Met  Gln Lys Gly Phe Val  Ser Ile Asn Asp Lys  Lys His Tyr 
    1985                 1990                 1995             


Phe Asp  Asp Ser Gly Val Met  Lys Val Gly Tyr Thr  Glu Ile Asp 
    2000                 2005                 2010             


Gly Lys  Tyr Phe Tyr Phe Ala  Glu Asn Gly Glu Met  Gln Ile Gly 
    2015                 2020                 2025             


Val Phe  Asn Thr Ser Asp Gly  Phe Lys Tyr Phe Ala  His Tyr Asn 
    2030                 2035                 2040             


Glu Asp  Leu Gly Asn Glu Glu  Gly Glu Ala Leu Ser  Tyr Ser Gly 
    2045                 2050                 2055             


Ile Leu  Asn Phe Asn Asn Lys  Ile Tyr Tyr Phe Asp  Asp Ser Phe 
    2060                 2065                 2070             


Thr Ala  Val Val Gly Trp Arg  Asn Leu Asp Asp Gly  Ser Lys Tyr 
    2075                 2080                 2085             


Tyr Phe  Asp Glu Asn Thr Ala  Glu Ala Phe Ile Gly  Phe Ser Leu 
    2090                 2095                 2100             


Ile Asn  Asp Glu Gln Tyr Tyr  Phe Asn Glu Asp Gly  Ile Met Gln 
    2105                 2110                 2115             


Val Gly  Phe Val Thr Ile Asn  Asp Arg Val Phe Tyr  Phe Ser Asp 
    2120                 2125                 2130             


Ser Gly  Ile Ile Glu Ser Gly  Val Gln Asn Ile Asp  Asp Asn Tyr 
    2135                 2140                 2145             


Phe Tyr  Ile Asp Glu Lys Gly  Ile Val Gln Ile Gly  Val Phe Asp 
    2150                 2155                 2160             


Thr Ser  Asp Gly Tyr Lys Tyr  Phe Ala Pro Pro Asn  Thr Val Asn 
    2165                 2170                 2175             


Glu Asn  Ile Tyr Gly Gln Ala  Val Glu Tyr Ser Gly  Leu Val Lys 
    2180                 2185                 2190             


Val Asn  Glu Asp Val Tyr Tyr  Phe Gly Glu Thr Tyr  Leu Ile Glu 
    2195                 2200                 2205             


Thr Gly  Trp Ile Tyr Asp Met  Glu Asn Glu Ser Asp  Lys Tyr Tyr 
    2210                 2215                 2220             


Phe Asp  Pro Glu Thr Lys Lys  Ala Tyr Lys Gly Ile  Asn Val Ile 
    2225                 2230                 2235             


Asn Asp  Thr Lys Tyr Tyr Phe  Asp Glu Asn Gly Ile  Met Arg Thr 
    2240                 2245                 2250             


Gly Leu  Ile Ser Phe Glu Asn  Asn His Tyr Tyr Phe  Asn Glu Asp 
    2255                 2260                 2265             


Gly Val  Met Gln Ser Gly Tyr  Ile Asn Ile Glu Asp  Lys Met Phe 
    2270                 2275                 2280             


Tyr Phe  Ser Glu Asp Gly Ile  Met Gln Ile Gly Val  Phe Asn Thr 
    2285                 2290                 2295             


Pro Asp  Gly Phe Lys Tyr Phe  Ala His Gln Asn Thr  Leu Asp Asp 
    2300                 2305                 2310             


Asn Phe  Glu Gly Glu Ser Ile  Asn Tyr Thr Gly Trp  Leu Asp Phe 
    2315                 2320                 2325             


Asn Glu  Lys Arg Tyr Tyr Phe  Thr Asp Glu Tyr Ile  Ala Ala Thr 
    2330                 2335                 2340             


Gly Ser  Val Thr Ile Asp Asp  Glu Glu Tyr Tyr Phe  Asp Pro Asp 
    2345                 2350                 2355             


Thr Ala  Glu Leu Val Leu Ser  Glu 
    2360                 2365     


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence conservation of key amino acids consisting of the 
       epitope-1 of bezlotoxumab


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Ile or Val

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Phe or Leu

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Asp, Glu, or Gly

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Ala or Gly

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Val, or Ile

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Pro or Thr

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Glu or Asp

<400>  44

Xaa Gly Glu Tyr Gln Ser Thr Glu Asp Gly Xaa Xaa Asn Arg Xaa Ala 
1               5                   10                  15      


Xaa Glu Xaa Xaa 
            20  


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence conservation of key amino acids consisting of the 
       epitope-2 of bezlotoxumab


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Val or Ser

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Glu, Ala, SEr

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Asp or Asn

<400>  45

Xaa Gly Tyr Tyr Glu Asn Thr Xaa Asp Gly Phe Asp Ser Thr Ala Val 
1               5                   10                  15      


Val Glu Xaa Thr 
            20  


<210>  46
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Receptor Decoy Antibody (RDA) composition 1

<400>  46

His His His His His His His His Ile Glu Gly Arg Pro Ala Ser Gly 
1               5                   10                  15      


Ser Leu Pro Glu Pro Cys Val Pro Glu Pro Gly Leu Pro Pro Val Phe 
            20                  25                  30          


Ala Asn Phe Thr Gln Leu Leu Thr Ile Ser Pro Leu Val Val Ala Glu 
        35                  40                  45              


Gly Gly Thr Ala Trp Leu Glu Trp Arg His Val Gln Pro Thr Leu Asp 
    50                  55                  60                  


Leu Met Glu Ala Glu Leu Arg Lys Ser Gln Val Leu Phe Ser Val Thr 
65                  70                  75                  80  


Arg Gly Ala Arg His Gly Glu Leu Glu Leu Asp Ile Pro Gly Ala Gln 
                85                  90                  95      


Ala Arg Lys Met Phe Thr Leu Leu Asp Val Val Asn Arg Lys Ala Arg 
            100                 105                 110         


Phe Ile His Asp Gly Ser Glu Asp Thr Ser Asp Gln Leu Val Leu Glu 
        115                 120                 125             


Val Ser Val Thr Ala Arg Val Pro Met Pro Ser Cys Leu Arg Arg Gly 
    130                 135                 140                 


Gln Thr Tyr Leu Leu Pro Ile Gln Val Asn Pro Val Asn Asp Ser Arg 
145                 150                 155                 160 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        195                 200                 205             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Val Asp Gln Tyr Asn Gly Glu Arg Gly Ile Ser 
                405                 410                 415     


Ile Pro Asp His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr 
            420                 425                 430         


Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr 
        435                 440                 445             


Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val 
    450                 455                 460                 


Lys Val Gln Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr 
465                 470                 475                 480 


Ala Pro Val Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser 
                485                 490                 495     


Leu Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe 
            500                 505                 510         


Gly Phe Gln Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His 
        515                 520                 525             


Gly Ala Gly Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly 
    530                 535                 540             


<210>  47
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   receptor decoy antibody (RDA) composition-1 with a humanized 5D 
       nanobody

<400>  47

His His His His His His His His Ile Glu Gly Arg Pro Ala Ser Gly 
1               5                   10                  15      


Ser Glu Leu Pro Glu Pro Cys Val Pro Glu Pro Gly Leu Pro Pro Val 
            20                  25                  30          


Phe Ala Asn Phe Thr Gln Leu Leu Thr Ile Ser Pro Leu Val Val Ala 
        35                  40                  45              


Glu Gly Gly Thr Ala Trp Leu Glu Trp Arg His Val Gln Pro Thr Leu 
    50                  55                  60                  


Asp Leu Met Glu Ala Glu Leu Arg Lys Ser Gln Val Leu Phe Ser Val 
65                  70                  75                  80  


Thr Arg Gly Ala Arg His Gly Glu Leu Glu Leu Asp Ile Pro Gly Ala 
                85                  90                  95      


Gln Ala Arg Lys Met Phe Thr Leu Leu Asp Val Val Asn Arg Lys Ala 
            100                 105                 110         


Arg Phe Ile His Asp Gly Ser Glu Asp Thr Ser Asp Gln Leu Val Leu 
        115                 120                 125             


Glu Val Ser Val Thr Ala Arg Val Pro Met Pro Ser Cys Leu Arg Arg 
    130                 135                 140                 


Gly Gln Thr Tyr Leu Leu Pro Ile Gln Val Asn Pro Val Asn Asp Ser 
145                 150                 155                 160 


Arg Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            180                 185                 190         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        195                 200                 205             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    210                 215                 220                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
225                 230                 235                 240 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                245                 250                 255     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            260                 265                 270         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        275                 280                 285             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    290                 295                 300                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
305                 310                 315                 320 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        355                 360                 365             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    370                 375                 380                 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Val Asp Gln Tyr Asn Gly Glu Arg Gly Ile 
                405                 410                 415     


Ser Ile Pro Asp His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys 
            420                 425                 430         


Thr Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His 
        435                 440                 445             


Thr Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu 
    450                 455                 460                 


Val Lys Val Gln Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met 
465                 470                 475                 480 


Tyr Ala Pro Val Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg 
                485                 490                 495     


Ser Leu Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys 
            500                 505                 510         


Phe Gly Phe Gln Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val 
        515                 520                 525             


His Gly Ala Gly Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly 
    530                 535                 540                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
545                 550                 555                 560 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
                565                 570                 575     


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val 
            580                 585                 590         


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
        595                 600                 605             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    610                 615                 620                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
625                 630                 635                 640 


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
                645                 650                 655     


Asp Tyr Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            660                 665                 670     


